-- dump date 20140619_124711 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568703000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 568703000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568703000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703000004 Walker A motif; other site 568703000005 ATP binding site [chemical binding]; other site 568703000006 Walker B motif; other site 568703000007 arginine finger; other site 568703000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568703000009 DnaA box-binding interface [nucleotide binding]; other site 568703000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 568703000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568703000012 putative DNA binding surface [nucleotide binding]; other site 568703000013 dimer interface [polypeptide binding]; other site 568703000014 beta-clamp/clamp loader binding surface; other site 568703000015 beta-clamp/translesion DNA polymerase binding surface; other site 568703000016 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 568703000017 recombination protein F; Reviewed; Region: recF; PRK00064 568703000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 568703000019 Walker A/P-loop; other site 568703000020 ATP binding site [chemical binding]; other site 568703000021 Q-loop/lid; other site 568703000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703000023 ABC transporter signature motif; other site 568703000024 Walker B; other site 568703000025 D-loop; other site 568703000026 H-loop/switch region; other site 568703000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 568703000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000029 Mg2+ binding site [ion binding]; other site 568703000030 G-X-G motif; other site 568703000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568703000032 anchoring element; other site 568703000033 dimer interface [polypeptide binding]; other site 568703000034 ATP binding site [chemical binding]; other site 568703000035 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568703000036 active site 568703000037 metal binding site [ion binding]; metal-binding site 568703000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703000039 DNA gyrase subunit A; Validated; Region: PRK05560 568703000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568703000041 CAP-like domain; other site 568703000042 active site 568703000043 primary dimer interface [polypeptide binding]; other site 568703000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000050 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 568703000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000053 dimer interface [polypeptide binding]; other site 568703000054 ssDNA binding site [nucleotide binding]; other site 568703000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000056 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568703000057 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703000058 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000059 dimer interface [polypeptide binding]; other site 568703000060 ssDNA binding site [nucleotide binding]; other site 568703000061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000062 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568703000063 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568703000064 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 568703000065 proposed catalytic triad [active] 568703000066 conserved cys residue [active] 568703000067 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703000068 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568703000069 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703000070 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703000071 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703000072 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703000073 Integrase core domain; Region: rve; pfam00665 568703000074 CAAX protease self-immunity; Region: Abi; pfam02517 568703000075 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000076 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000077 CAAX protease self-immunity; Region: Abi; pfam02517 568703000078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703000079 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000080 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703000082 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703000083 Walker A/P-loop; other site 568703000084 ATP binding site [chemical binding]; other site 568703000085 Q-loop/lid; other site 568703000086 ABC transporter signature motif; other site 568703000087 Walker B; other site 568703000088 D-loop; other site 568703000089 H-loop/switch region; other site 568703000090 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 568703000091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 568703000092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703000093 CHAP domain; Region: CHAP; pfam05257 568703000094 Surface antigen [General function prediction only]; Region: COG3942 568703000095 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000097 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703000098 FtsX-like permease family; Region: FtsX; pfam02687 568703000099 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000100 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703000101 Walker A/P-loop; other site 568703000102 ATP binding site [chemical binding]; other site 568703000103 Q-loop/lid; other site 568703000104 ABC transporter signature motif; other site 568703000105 Walker B; other site 568703000106 D-loop; other site 568703000107 H-loop/switch region; other site 568703000108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 568703000111 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703000112 active site 568703000113 motif I; other site 568703000114 motif II; other site 568703000115 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703000116 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000117 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703000118 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 568703000119 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 568703000120 active site 568703000121 substrate binding site [chemical binding]; other site 568703000122 trimer interface [polypeptide binding]; other site 568703000123 CoA binding site [chemical binding]; other site 568703000124 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703000125 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 568703000126 active site 568703000127 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 568703000128 Predicted membrane protein [Function unknown]; Region: COG4392 568703000129 beta-D-glucuronidase; Provisional; Region: PRK10150 568703000130 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703000131 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 568703000132 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 568703000133 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000134 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 568703000135 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 568703000136 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703000137 active site 568703000138 intersubunit interface [polypeptide binding]; other site 568703000139 catalytic residue [active] 568703000140 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000141 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000142 substrate binding site [chemical binding]; other site 568703000143 ATP binding site [chemical binding]; other site 568703000144 Glucuronate isomerase; Region: UxaC; cl00829 568703000145 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568703000146 Glucuronate isomerase; Region: UxaC; cl00829 568703000147 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568703000148 mannonate dehydratase; Region: uxuA; TIGR00695 568703000149 mannonate dehydratase; Provisional; Region: PRK03906 568703000150 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568703000151 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703000152 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703000153 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703000154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703000157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000158 DNA-binding site [nucleotide binding]; DNA binding site 568703000159 FCD domain; Region: FCD; pfam07729 568703000160 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000161 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000162 substrate binding site [chemical binding]; other site 568703000163 ATP binding site [chemical binding]; other site 568703000164 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000165 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568703000166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000168 putative substrate translocation pore; other site 568703000169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000170 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703000171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000173 MMPL family; Region: MMPL; pfam03176 568703000174 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 568703000175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000178 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 568703000179 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703000180 active site 568703000181 putative diguanylate cyclase; Provisional; Region: PRK09776 568703000182 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 568703000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000184 dimer interface [polypeptide binding]; other site 568703000185 conserved gate region; other site 568703000186 putative PBP binding loops; other site 568703000187 ABC-ATPase subunit interface; other site 568703000188 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703000189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000190 dimer interface [polypeptide binding]; other site 568703000191 conserved gate region; other site 568703000192 putative PBP binding loops; other site 568703000193 ABC-ATPase subunit interface; other site 568703000194 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568703000195 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 568703000196 Walker A/P-loop; other site 568703000197 ATP binding site [chemical binding]; other site 568703000198 Q-loop/lid; other site 568703000199 ABC transporter signature motif; other site 568703000200 Walker B; other site 568703000201 D-loop; other site 568703000202 H-loop/switch region; other site 568703000203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 568703000204 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 568703000205 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 568703000206 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703000207 DNA binding residues [nucleotide binding] 568703000208 dimer interface [polypeptide binding]; other site 568703000209 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000211 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703000212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568703000213 metal-binding site [ion binding] 568703000214 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 568703000215 dinuclear metal binding motif [ion binding]; other site 568703000216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568703000217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568703000218 ligand binding site [chemical binding]; other site 568703000219 flexible hinge region; other site 568703000220 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568703000221 putative switch regulator; other site 568703000222 non-specific DNA interactions [nucleotide binding]; other site 568703000223 DNA binding site [nucleotide binding] 568703000224 sequence specific DNA binding site [nucleotide binding]; other site 568703000225 putative cAMP binding site [chemical binding]; other site 568703000226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000228 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 568703000229 CAAX protease self-immunity; Region: Abi; pfam02517 568703000230 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703000231 active site 568703000232 P-loop; other site 568703000233 phosphorylation site [posttranslational modification] 568703000234 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 568703000235 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 568703000236 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000237 active site 568703000238 phosphorylation site [posttranslational modification] 568703000239 alpha-mannosidase; Provisional; Region: PRK09819 568703000240 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 568703000241 active site 568703000242 metal binding site [ion binding]; metal-binding site 568703000243 catalytic site [active] 568703000244 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 568703000245 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000246 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000247 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000248 putative active site [active] 568703000249 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703000250 beta-galactosidase; Region: BGL; TIGR03356 568703000251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703000252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703000253 nucleotide binding site [chemical binding]; other site 568703000254 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 568703000255 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568703000256 substrate binding site [chemical binding]; other site 568703000257 active site 568703000258 catalytic residues [active] 568703000259 heterodimer interface [polypeptide binding]; other site 568703000260 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568703000261 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568703000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000263 catalytic residue [active] 568703000264 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568703000265 active site 568703000266 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568703000267 active site 568703000268 ribulose/triose binding site [chemical binding]; other site 568703000269 phosphate binding site [ion binding]; other site 568703000270 substrate (anthranilate) binding pocket [chemical binding]; other site 568703000271 product (indole) binding pocket [chemical binding]; other site 568703000272 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568703000273 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703000274 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703000275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000277 putative substrate translocation pore; other site 568703000278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000281 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 568703000282 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 568703000283 dihydrodipicolinate reductase; Provisional; Region: PRK00048 568703000284 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568703000285 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568703000286 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568703000287 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568703000288 dimer interface [polypeptide binding]; other site 568703000289 active site 568703000290 catalytic residue [active] 568703000291 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703000292 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 568703000293 metal binding site [ion binding]; metal-binding site 568703000294 putative dimer interface [polypeptide binding]; other site 568703000295 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 568703000296 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 568703000297 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000298 putative trimer interface [polypeptide binding]; other site 568703000299 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000300 putative CoA binding site [chemical binding]; other site 568703000301 putative trimer interface [polypeptide binding]; other site 568703000302 putative CoA binding site [chemical binding]; other site 568703000303 diaminopimelate decarboxylase; Region: lysA; TIGR01048 568703000304 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568703000305 active site 568703000306 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703000307 substrate binding site [chemical binding]; other site 568703000308 catalytic residues [active] 568703000309 dimer interface [polypeptide binding]; other site 568703000310 aspartate kinase; Reviewed; Region: PRK09034 568703000311 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 568703000312 putative catalytic residues [active] 568703000313 putative nucleotide binding site [chemical binding]; other site 568703000314 putative aspartate binding site [chemical binding]; other site 568703000315 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 568703000316 allosteric regulatory residue; other site 568703000317 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703000318 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568703000319 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568703000320 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568703000321 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 568703000322 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568703000323 Peptidase M15; Region: Peptidase_M15_3; cl01194 568703000324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000325 non-specific DNA binding site [nucleotide binding]; other site 568703000326 salt bridge; other site 568703000327 sequence-specific DNA binding site [nucleotide binding]; other site 568703000328 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 568703000329 nudix motif; other site 568703000330 EamA-like transporter family; Region: EamA; pfam00892 568703000331 xanthine dehydrogenase; Region: PLN02906 568703000332 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 568703000333 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703000334 DHH family; Region: DHH; pfam01368 568703000335 DHHA1 domain; Region: DHHA1; pfam02272 568703000336 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568703000337 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568703000338 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568703000339 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568703000340 replicative DNA helicase; Provisional; Region: PRK05748 568703000341 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568703000342 Walker A motif; other site 568703000343 ATP binding site [chemical binding]; other site 568703000344 Walker B motif; other site 568703000345 DNA binding loops [nucleotide binding] 568703000346 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703000347 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703000348 active site turn [active] 568703000349 phosphorylation site [posttranslational modification] 568703000350 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703000351 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703000352 HPr interaction site; other site 568703000353 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703000354 active site 568703000355 phosphorylation site [posttranslational modification] 568703000356 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703000357 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703000358 putative active site [active] 568703000359 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703000360 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703000361 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000362 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000363 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000364 putative active site [active] 568703000365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000367 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 568703000368 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000369 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703000370 Walker A/P-loop; other site 568703000371 ATP binding site [chemical binding]; other site 568703000372 Q-loop/lid; other site 568703000373 ABC transporter signature motif; other site 568703000374 Walker B; other site 568703000375 D-loop; other site 568703000376 H-loop/switch region; other site 568703000377 FtsX-like permease family; Region: FtsX; pfam02687 568703000378 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000379 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703000380 FtsX-like permease family; Region: FtsX; pfam02687 568703000381 Amidohydrolase; Region: Amidohydro_2; pfam04909 568703000382 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568703000383 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568703000384 GDP-binding site [chemical binding]; other site 568703000385 ACT binding site; other site 568703000386 IMP binding site; other site 568703000387 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000389 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 568703000390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703000391 dimerization interface [polypeptide binding]; other site 568703000392 putative DNA binding site [nucleotide binding]; other site 568703000393 putative Zn2+ binding site [ion binding]; other site 568703000394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000395 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 568703000396 ATP cone domain; Region: ATP-cone; pfam03477 568703000397 Class III ribonucleotide reductase; Region: RNR_III; cd01675 568703000398 effector binding site; other site 568703000399 active site 568703000400 Zn binding site [ion binding]; other site 568703000401 glycine loop; other site 568703000402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703000403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000404 non-specific DNA binding site [nucleotide binding]; other site 568703000405 salt bridge; other site 568703000406 sequence-specific DNA binding site [nucleotide binding]; other site 568703000407 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703000408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 568703000409 Transposase; Region: DEDD_Tnp_IS110; pfam01548 568703000410 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 568703000411 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 568703000412 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568703000413 active site 568703000414 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 568703000415 putative dimer interface [polypeptide binding]; other site 568703000416 catalytic triad [active] 568703000417 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568703000418 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568703000419 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703000420 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703000421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000422 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703000423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703000424 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703000426 HAMP domain; Region: HAMP; pfam00672 568703000427 dimerization interface [polypeptide binding]; other site 568703000428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703000429 dimer interface [polypeptide binding]; other site 568703000430 phosphorylation site [posttranslational modification] 568703000431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000432 ATP binding site [chemical binding]; other site 568703000433 Mg2+ binding site [ion binding]; other site 568703000434 G-X-G motif; other site 568703000435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703000437 active site 568703000438 phosphorylation site [posttranslational modification] 568703000439 intermolecular recognition site; other site 568703000440 dimerization interface [polypeptide binding]; other site 568703000441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703000442 DNA binding site [nucleotide binding] 568703000443 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568703000444 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568703000445 DNA binding site [nucleotide binding] 568703000446 active site 568703000447 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 568703000448 D-lactate dehydrogenase; Validated; Region: PRK08605 568703000449 homodimer interface [polypeptide binding]; other site 568703000450 ligand binding site [chemical binding]; other site 568703000451 NAD binding site [chemical binding]; other site 568703000452 catalytic site [active] 568703000453 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000454 active site 568703000455 P-loop; other site 568703000456 phosphorylation site [posttranslational modification] 568703000457 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000458 active site 568703000459 methionine cluster; other site 568703000460 phosphorylation site [posttranslational modification] 568703000461 metal binding site [ion binding]; metal-binding site 568703000462 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703000463 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000464 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703000465 beta-galactosidase; Region: BGL; TIGR03356 568703000466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000467 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000468 DNA-binding site [nucleotide binding]; DNA binding site 568703000469 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703000470 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 568703000471 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 568703000472 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568703000473 DsrE/DsrF-like family; Region: DrsE; cl00672 568703000474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000475 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568703000476 Walker A/P-loop; other site 568703000477 ATP binding site [chemical binding]; other site 568703000478 Q-loop/lid; other site 568703000479 ABC transporter signature motif; other site 568703000480 Walker B; other site 568703000481 D-loop; other site 568703000482 H-loop/switch region; other site 568703000483 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703000484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568703000485 substrate binding pocket [chemical binding]; other site 568703000486 membrane-bound complex binding site; other site 568703000487 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000489 dimer interface [polypeptide binding]; other site 568703000490 conserved gate region; other site 568703000491 putative PBP binding loops; other site 568703000492 ABC-ATPase subunit interface; other site 568703000493 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 568703000494 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 568703000495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000497 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703000498 active site residue [active] 568703000499 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 568703000500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703000501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703000502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703000503 dimerization interface [polypeptide binding]; other site 568703000504 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703000505 Zn binding site [ion binding]; other site 568703000506 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703000507 Zn binding site [ion binding]; other site 568703000508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703000509 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703000510 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703000511 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703000512 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703000513 Protein of unknown function (DUF805); Region: DUF805; pfam05656 568703000514 Protein of unknown function (DUF805); Region: DUF805; pfam05656 568703000515 recombination factor protein RarA; Reviewed; Region: PRK13342 568703000516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703000517 Walker A motif; other site 568703000518 ATP binding site [chemical binding]; other site 568703000519 Walker B motif; other site 568703000520 arginine finger; other site 568703000521 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703000522 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568703000523 propionate/acetate kinase; Provisional; Region: PRK12379 568703000524 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000525 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703000526 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000527 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703000528 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 568703000529 N- and C-terminal domain interface [polypeptide binding]; other site 568703000530 active site 568703000531 MgATP binding site [chemical binding]; other site 568703000532 catalytic site [active] 568703000533 metal binding site [ion binding]; metal-binding site 568703000534 carbohydrate binding site [chemical binding]; other site 568703000535 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703000536 intersubunit interface [polypeptide binding]; other site 568703000537 active site 568703000538 zinc binding site [ion binding]; other site 568703000539 Na+ binding site [ion binding]; other site 568703000540 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 568703000541 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 568703000542 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703000543 active site 568703000544 metal binding site [ion binding]; metal-binding site 568703000545 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703000546 endonuclease III; Region: ENDO3c; smart00478 568703000547 minor groove reading motif; other site 568703000548 helix-hairpin-helix signature motif; other site 568703000549 substrate binding pocket [chemical binding]; other site 568703000550 active site 568703000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000553 putative substrate translocation pore; other site 568703000554 putative phosphoketolase; Provisional; Region: PRK05261 568703000555 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 568703000556 TPP-binding site; other site 568703000557 XFP C-terminal domain; Region: XFP_C; pfam09363 568703000558 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000559 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000560 peptide binding site [polypeptide binding]; other site 568703000561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703000562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000563 Walker A/P-loop; other site 568703000564 ATP binding site [chemical binding]; other site 568703000565 Q-loop/lid; other site 568703000566 ABC transporter signature motif; other site 568703000567 Walker B; other site 568703000568 D-loop; other site 568703000569 H-loop/switch region; other site 568703000570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 568703000571 nudix motif; other site 568703000572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703000573 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703000574 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 568703000575 Walker A/P-loop; other site 568703000576 ATP binding site [chemical binding]; other site 568703000577 Q-loop/lid; other site 568703000578 ABC transporter signature motif; other site 568703000579 Walker B; other site 568703000580 D-loop; other site 568703000581 H-loop/switch region; other site 568703000582 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703000583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000584 non-specific DNA binding site [nucleotide binding]; other site 568703000585 salt bridge; other site 568703000586 sequence-specific DNA binding site [nucleotide binding]; other site 568703000587 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703000588 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 568703000589 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000591 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000592 Repair protein; Region: Repair_PSII; pfam04536 568703000593 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000594 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 568703000595 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568703000596 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 568703000597 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568703000598 putative ligand binding site [chemical binding]; other site 568703000599 putative NAD binding site [chemical binding]; other site 568703000600 catalytic site [active] 568703000601 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568703000602 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 568703000603 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 568703000604 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 568703000605 Asp23 family; Region: Asp23; pfam03780 568703000606 Asp23 family; Region: Asp23; pfam03780 568703000607 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 568703000608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703000609 motif II; other site 568703000610 Protein of unknown function (DUF969); Region: DUF969; pfam06149 568703000611 Predicted membrane protein [Function unknown]; Region: COG3817 568703000612 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703000613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703000614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703000615 Predicted membrane protein [Function unknown]; Region: COG3817 568703000616 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 568703000617 putative substrate binding pocket [chemical binding]; other site 568703000618 AC domain interface; other site 568703000619 catalytic triad [active] 568703000620 AB domain interface; other site 568703000621 interchain disulfide; other site 568703000622 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703000623 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703000624 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 568703000625 catalytic triad [active] 568703000626 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 568703000627 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 568703000628 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 568703000629 ParB-like nuclease domain; Region: ParBc; pfam02195 568703000630 KorB domain; Region: KorB; pfam08535 568703000631 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 568703000632 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568703000633 P-loop; other site 568703000634 Magnesium ion binding site [ion binding]; other site 568703000635 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568703000636 Magnesium ion binding site [ion binding]; other site 568703000637 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 568703000638 ParB-like nuclease domain; Region: ParB; smart00470 568703000639 KorB domain; Region: KorB; pfam08535 568703000640 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 568703000641 GTP-binding protein YchF; Reviewed; Region: PRK09601 568703000642 YchF GTPase; Region: YchF; cd01900 568703000643 G1 box; other site 568703000644 GTP/Mg2+ binding site [chemical binding]; other site 568703000645 Switch I region; other site 568703000646 G2 box; other site 568703000647 Switch II region; other site 568703000648 G3 box; other site 568703000649 G4 box; other site 568703000650 G5 box; other site 568703000651 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568703000652 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 568703000653 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568703000654 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568703000655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568703000656 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568703000657 active site 568703000658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703000660 active site 568703000661 phosphorylation site [posttranslational modification] 568703000662 intermolecular recognition site; other site 568703000663 dimerization interface [polypeptide binding]; other site 568703000664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703000665 DNA binding site [nucleotide binding] 568703000666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703000667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 568703000668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703000669 dimer interface [polypeptide binding]; other site 568703000670 phosphorylation site [posttranslational modification] 568703000671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000672 ATP binding site [chemical binding]; other site 568703000673 Mg2+ binding site [ion binding]; other site 568703000674 G-X-G motif; other site 568703000675 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568703000676 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568703000677 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 568703000678 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703000679 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568703000680 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568703000681 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568703000682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703000683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703000684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703000685 aspartate racemase; Region: asp_race; TIGR00035 568703000686 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568703000687 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703000688 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703000689 active site 568703000690 catalytic tetrad [active] 568703000691 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000692 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703000693 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000694 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703000695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000696 putative substrate translocation pore; other site 568703000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000698 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568703000699 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568703000700 tetrameric interface [polypeptide binding]; other site 568703000701 NAD binding site [chemical binding]; other site 568703000702 catalytic residues [active] 568703000703 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 568703000704 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000705 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000706 substrate binding site [chemical binding]; other site 568703000707 ATP binding site [chemical binding]; other site 568703000708 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 568703000709 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703000710 PYR/PP interface [polypeptide binding]; other site 568703000711 dimer interface [polypeptide binding]; other site 568703000712 TPP binding site [chemical binding]; other site 568703000713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703000714 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 568703000715 TPP-binding site; other site 568703000716 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000717 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703000718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703000720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568703000721 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000722 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703000723 intersubunit interface [polypeptide binding]; other site 568703000724 active site 568703000725 zinc binding site [ion binding]; other site 568703000726 Na+ binding site [ion binding]; other site 568703000727 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568703000728 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 568703000729 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000730 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000731 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000732 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000733 putative active site [active] 568703000734 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703000735 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 568703000736 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 568703000737 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 568703000738 N- and C-terminal domain interface [polypeptide binding]; other site 568703000739 active site 568703000740 catalytic site [active] 568703000741 metal binding site [ion binding]; metal-binding site 568703000742 carbohydrate binding site [chemical binding]; other site 568703000743 ATP binding site [chemical binding]; other site 568703000744 fructuronate transporter; Provisional; Region: PRK10034; cl15264 568703000745 Citrate transporter; Region: CitMHS; pfam03600 568703000746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703000747 active site 568703000748 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703000749 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000750 Probable Catalytic site; other site 568703000751 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000752 Probable Catalytic site; other site 568703000753 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703000754 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 568703000755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703000756 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568703000757 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568703000758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 568703000759 putative PBP binding regions; other site 568703000760 ABC-ATPase subunit interface; other site 568703000761 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 568703000762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703000763 active site 568703000764 metal binding site [ion binding]; metal-binding site 568703000765 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568703000766 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703000767 oligoendopeptidase F; Region: pepF; TIGR00181 568703000768 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 568703000769 active site 568703000770 Zn binding site [ion binding]; other site 568703000771 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703000772 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703000773 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000774 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568703000775 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703000777 active site 568703000778 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703000779 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 568703000780 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000781 Catalytic site [active] 568703000782 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000783 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 568703000784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703000785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000787 ABC transporter; Region: ABC_tran_2; pfam12848 568703000788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703000790 S-adenosylmethionine binding site [chemical binding]; other site 568703000791 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703000792 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703000793 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703000794 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703000795 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568703000796 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 568703000797 putative ligand binding site [chemical binding]; other site 568703000798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703000799 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568703000800 TM-ABC transporter signature motif; other site 568703000801 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568703000802 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568703000803 TM-ABC transporter signature motif; other site 568703000804 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568703000805 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568703000806 Walker A/P-loop; other site 568703000807 ATP binding site [chemical binding]; other site 568703000808 Q-loop/lid; other site 568703000809 ABC transporter signature motif; other site 568703000810 Walker B; other site 568703000811 D-loop; other site 568703000812 H-loop/switch region; other site 568703000813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703000814 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568703000815 Walker A/P-loop; other site 568703000816 ATP binding site [chemical binding]; other site 568703000817 Q-loop/lid; other site 568703000818 ABC transporter signature motif; other site 568703000819 Walker B; other site 568703000820 D-loop; other site 568703000821 H-loop/switch region; other site 568703000822 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 568703000823 metal binding site [ion binding]; metal-binding site 568703000824 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703000825 PGAP1-like protein; Region: PGAP1; pfam07819 568703000826 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000827 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 568703000828 intersubunit interface [polypeptide binding]; other site 568703000829 active site 568703000830 catalytic residue [active] 568703000831 phosphopentomutase; Provisional; Region: PRK05362 568703000832 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 568703000833 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 568703000834 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568703000835 NlpC/P60 family; Region: NLPC_P60; pfam00877 568703000836 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000838 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 568703000839 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568703000840 DEAD_2; Region: DEAD_2; pfam06733 568703000841 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568703000842 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703000843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703000844 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 568703000845 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 568703000846 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000848 DNA-binding site [nucleotide binding]; DNA binding site 568703000849 UTRA domain; Region: UTRA; pfam07702 568703000850 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 568703000851 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703000852 dimer interface [polypeptide binding]; other site 568703000853 active site 568703000854 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 568703000855 putative active site [active] 568703000856 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 568703000857 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703000858 active site 568703000859 dimer interface [polypeptide binding]; other site 568703000860 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 568703000861 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703000862 active site 568703000863 phosphorylation site [posttranslational modification] 568703000864 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703000865 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703000866 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703000867 active pocket/dimerization site; other site 568703000868 active site 568703000869 phosphorylation site [posttranslational modification] 568703000870 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703000871 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703000872 putative substrate binding site [chemical binding]; other site 568703000873 putative ATP binding site [chemical binding]; other site 568703000874 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 568703000875 classical (c) SDRs; Region: SDR_c; cd05233 568703000876 NAD(P) binding site [chemical binding]; other site 568703000877 active site 568703000878 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703000879 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000880 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000881 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000882 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000883 active site 568703000884 phosphorylation site [posttranslational modification] 568703000885 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703000886 active site 568703000887 P-loop; other site 568703000888 phosphorylation site [posttranslational modification] 568703000889 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000890 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703000892 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000893 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703000895 Rap/ran-GAP; Region: Rap_GAP; pfam02145 568703000896 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 568703000897 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 568703000898 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000900 homodimer interface [polypeptide binding]; other site 568703000901 catalytic residue [active] 568703000902 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703000903 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703000904 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703000905 active site 568703000906 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000907 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703000908 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000909 active site 568703000910 P-loop; other site 568703000911 phosphorylation site [posttranslational modification] 568703000912 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000913 active site 568703000914 methionine cluster; other site 568703000915 phosphorylation site [posttranslational modification] 568703000916 metal binding site [ion binding]; metal-binding site 568703000917 exoaminopeptidase; Provisional; Region: PRK09961 568703000918 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 568703000919 oligomer interface [polypeptide binding]; other site 568703000920 active site 568703000921 metal binding site [ion binding]; metal-binding site 568703000922 HTH domain; Region: HTH_11; pfam08279 568703000923 PRD domain; Region: PRD; pfam00874 568703000924 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703000925 active site 568703000926 P-loop; other site 568703000927 phosphorylation site [posttranslational modification] 568703000928 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703000929 active site 568703000930 phosphorylation site [posttranslational modification] 568703000931 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 568703000932 peptidase T; Region: peptidase-T; TIGR01882 568703000933 metal binding site [ion binding]; metal-binding site 568703000934 dimer interface [polypeptide binding]; other site 568703000935 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000936 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000937 peptide binding site [polypeptide binding]; other site 568703000938 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703000939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703000940 Coenzyme A binding pocket [chemical binding]; other site 568703000941 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703000942 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703000943 Walker A/P-loop; other site 568703000944 ATP binding site [chemical binding]; other site 568703000945 Q-loop/lid; other site 568703000946 ABC transporter signature motif; other site 568703000947 Walker B; other site 568703000948 D-loop; other site 568703000949 H-loop/switch region; other site 568703000950 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 568703000951 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703000952 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000953 Walker A/P-loop; other site 568703000954 ATP binding site [chemical binding]; other site 568703000955 Q-loop/lid; other site 568703000956 ABC transporter signature motif; other site 568703000957 Walker B; other site 568703000958 D-loop; other site 568703000959 H-loop/switch region; other site 568703000960 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 568703000961 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000962 Walker A/P-loop; other site 568703000963 ATP binding site [chemical binding]; other site 568703000964 Q-loop/lid; other site 568703000965 ABC transporter signature motif; other site 568703000966 Walker B; other site 568703000967 D-loop; other site 568703000968 H-loop/switch region; other site 568703000969 Putative transcription activator [Transcription]; Region: TenA; COG0819 568703000970 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 568703000971 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 568703000972 substrate binding site [chemical binding]; other site 568703000973 multimerization interface [polypeptide binding]; other site 568703000974 ATP binding site [chemical binding]; other site 568703000975 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568703000976 thiamine phosphate binding site [chemical binding]; other site 568703000977 active site 568703000978 pyrophosphate binding site [ion binding]; other site 568703000979 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703000980 dimer interface [polypeptide binding]; other site 568703000981 substrate binding site [chemical binding]; other site 568703000982 ATP binding site [chemical binding]; other site 568703000983 Amino acid permease; Region: AA_permease_2; pfam13520 568703000984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703000985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703000986 DNA binding site [nucleotide binding] 568703000987 domain linker motif; other site 568703000988 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703000989 ligand binding site [chemical binding]; other site 568703000990 dimerization interface [polypeptide binding]; other site 568703000991 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000992 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568703000993 substrate binding site [chemical binding]; other site 568703000994 dimer interface [polypeptide binding]; other site 568703000995 ATP binding site [chemical binding]; other site 568703000996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000997 salt bridge; other site 568703000998 non-specific DNA binding site [nucleotide binding]; other site 568703000999 sequence-specific DNA binding site [nucleotide binding]; other site 568703001000 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001001 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001002 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703001003 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 568703001004 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703001005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703001006 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001007 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 568703001009 non-specific DNA binding site [nucleotide binding]; other site 568703001010 salt bridge; other site 568703001011 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568703001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001013 putative substrate translocation pore; other site 568703001014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703001015 MarR family; Region: MarR_2; cl17246 568703001016 MarR family; Region: MarR_2; cl17246 568703001017 Soybean trypsin inhibitor (Kunitz) family of protease inhibitors. Inhibit proteases by binding with high affinity to their active sites. Trefoil fold, common to interleukins and fibroblast growth factors; Region: STI; cl11466 568703001018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001019 non-specific DNA binding site [nucleotide binding]; other site 568703001020 salt bridge; other site 568703001021 sequence-specific DNA binding site [nucleotide binding]; other site 568703001022 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703001023 HTH domain; Region: HTH_11; pfam08279 568703001024 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703001025 PRD domain; Region: PRD; pfam00874 568703001026 PRD domain; Region: PRD; pfam00874 568703001027 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703001028 active site 568703001029 P-loop; other site 568703001030 phosphorylation site [posttranslational modification] 568703001031 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703001032 active site 568703001033 phosphorylation site [posttranslational modification] 568703001034 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001035 active site 568703001036 phosphorylation site [posttranslational modification] 568703001037 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703001038 active site 568703001039 P-loop; other site 568703001040 phosphorylation site [posttranslational modification] 568703001041 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703001042 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703001043 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 568703001044 active site 568703001045 intersubunit interactions; other site 568703001046 catalytic residue [active] 568703001047 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568703001048 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568703001049 substrate binding site [chemical binding]; other site 568703001050 hexamer interface [polypeptide binding]; other site 568703001051 metal binding site [ion binding]; metal-binding site 568703001052 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001053 active site 568703001054 phosphorylation site [posttranslational modification] 568703001055 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703001056 active site 568703001057 P-loop; other site 568703001058 phosphorylation site [posttranslational modification] 568703001059 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703001060 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001061 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001062 Integrase core domain; Region: rve; pfam00665 568703001063 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 568703001064 transketolase; Reviewed; Region: PRK05899 568703001065 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568703001066 TPP-binding site [chemical binding]; other site 568703001067 dimer interface [polypeptide binding]; other site 568703001068 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 568703001069 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568703001070 PYR/PP interface [polypeptide binding]; other site 568703001071 dimer interface [polypeptide binding]; other site 568703001072 TPP binding site [chemical binding]; other site 568703001073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703001074 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703001075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703001076 nucleotide binding site [chemical binding]; other site 568703001077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568703001078 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001079 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568703001080 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703001081 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001082 active site 568703001083 phosphorylation site [posttranslational modification] 568703001084 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703001085 active site 568703001086 P-loop; other site 568703001087 phosphorylation site [posttranslational modification] 568703001088 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703001089 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001090 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001091 Integrase core domain; Region: rve; pfam00665 568703001092 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001093 intersubunit interface [polypeptide binding]; other site 568703001094 active site 568703001095 zinc binding site [ion binding]; other site 568703001096 Na+ binding site [ion binding]; other site 568703001097 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001098 intersubunit interface [polypeptide binding]; other site 568703001099 active site 568703001100 zinc binding site [ion binding]; other site 568703001101 Na+ binding site [ion binding]; other site 568703001102 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703001103 active site 568703001104 phosphorylation site [posttranslational modification] 568703001105 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703001106 active pocket/dimerization site; other site 568703001107 active site 568703001108 phosphorylation site [posttranslational modification] 568703001109 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703001110 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703001111 putative translaldolase; Provisional; Region: PRK12376 568703001112 catalytic residue [active] 568703001113 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703001114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001115 DNA binding site [nucleotide binding] 568703001116 domain linker motif; other site 568703001117 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703001118 dimerization interface [polypeptide binding]; other site 568703001119 ligand binding site [chemical binding]; other site 568703001120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 568703001121 DNA-binding site [nucleotide binding]; DNA binding site 568703001122 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568703001123 substrate binding pocket [chemical binding]; other site 568703001124 membrane-bound complex binding site; other site 568703001125 hinge residues; other site 568703001126 PRD domain; Region: PRD; pfam00874 568703001127 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 568703001128 Protein of unknown function; Region: YhfT; pfam10797 568703001129 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 568703001130 active site 568703001131 substrate binding pocket [chemical binding]; other site 568703001132 homodimer interaction site [polypeptide binding]; other site 568703001133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703001134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703001135 catalytic residue [active] 568703001136 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 568703001137 dimer interface [polypeptide binding]; other site 568703001138 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 568703001139 active site 568703001140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703001141 substrate binding site [chemical binding]; other site 568703001142 catalytic residue [active] 568703001143 putative mutase; Provisional; Region: PRK12383 568703001144 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 568703001145 Uncharacterized conserved protein [Function unknown]; Region: COG1912 568703001146 hypothetical protein; Provisional; Region: PRK13661 568703001147 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703001148 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001149 Walker A/P-loop; other site 568703001150 ATP binding site [chemical binding]; other site 568703001151 Q-loop/lid; other site 568703001152 ABC transporter signature motif; other site 568703001153 Walker B; other site 568703001154 D-loop; other site 568703001155 H-loop/switch region; other site 568703001156 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 568703001157 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703001158 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001159 Walker A/P-loop; other site 568703001160 ATP binding site [chemical binding]; other site 568703001161 Q-loop/lid; other site 568703001162 ABC transporter signature motif; other site 568703001163 Walker B; other site 568703001164 D-loop; other site 568703001165 H-loop/switch region; other site 568703001166 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 568703001167 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 568703001168 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 568703001169 active site 568703001170 octamer interface [polypeptide binding]; other site 568703001171 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568703001172 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 568703001173 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001174 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001175 Integrase core domain; Region: rve; pfam00665 568703001176 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568703001177 multiple promoter invertase; Provisional; Region: mpi; PRK13413 568703001178 catalytic residues [active] 568703001179 catalytic nucleophile [active] 568703001180 Presynaptic Site I dimer interface [polypeptide binding]; other site 568703001181 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568703001182 Synaptic Flat tetramer interface [polypeptide binding]; other site 568703001183 Synaptic Site I dimer interface [polypeptide binding]; other site 568703001184 DNA binding site [nucleotide binding] 568703001185 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568703001186 Dimer interface [polypeptide binding]; other site 568703001187 AP2 domain; Region: AP2; pfam00847 568703001188 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703001189 active site 568703001190 catalytic site [active] 568703001191 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703001192 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703001193 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 568703001194 metal ion-dependent adhesion site (MIDAS); other site 568703001195 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 568703001196 domain interaction interfaces [polypeptide binding]; other site 568703001197 Cna protein B-type domain; Region: Cna_B; pfam05738 568703001198 Cna protein B-type domain; Region: Cna_B; pfam05738 568703001199 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001200 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001201 Integrase core domain; Region: rve; pfam00665 568703001202 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703001203 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703001204 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 568703001205 Part of AAA domain; Region: AAA_19; pfam13245 568703001206 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 568703001207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001208 Walker A/P-loop; other site 568703001209 ATP binding site [chemical binding]; other site 568703001210 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 568703001211 putative active site [active] 568703001212 putative metal-binding site [ion binding]; other site 568703001213 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001214 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703001216 Transposase; Region: HTH_Tnp_1; pfam01527 568703001217 putative transposase OrfB; Reviewed; Region: PHA02517 568703001218 HTH-like domain; Region: HTH_21; pfam13276 568703001219 Integrase core domain; Region: rve; pfam00665 568703001220 Integrase core domain; Region: rve_3; pfam13683 568703001221 putative transposase OrfB; Reviewed; Region: PHA02517 568703001222 HTH-like domain; Region: HTH_21; pfam13276 568703001223 Integrase core domain; Region: rve; pfam00665 568703001224 Integrase core domain; Region: rve_2; pfam13333 568703001225 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001226 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703001227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001228 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703001229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001230 active site 568703001231 motif I; other site 568703001232 motif II; other site 568703001233 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001234 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001236 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001237 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703001238 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 568703001239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001240 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001241 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568703001243 Integrase core domain; Region: rve; pfam00665 568703001244 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 568703001245 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568703001246 Cl- selectivity filter; other site 568703001247 Cl- binding residues [ion binding]; other site 568703001248 pore gating glutamate residue; other site 568703001249 dimer interface [polypeptide binding]; other site 568703001250 H+/Cl- coupling transport residue; other site 568703001251 TrkA-C domain; Region: TrkA_C; pfam02080 568703001252 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001253 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001254 Integrase core domain; Region: rve; pfam00665 568703001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001256 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001257 putative substrate translocation pore; other site 568703001258 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001259 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001260 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 568703001261 hypothetical protein; Provisional; Region: PRK06446 568703001262 metal binding site [ion binding]; metal-binding site 568703001263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703001266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001267 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 568703001268 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703001269 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 568703001270 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 568703001271 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 568703001272 inner membrane transporter YjeM; Provisional; Region: PRK15238 568703001273 lysine transporter; Provisional; Region: PRK10836 568703001274 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568703001275 Transcriptional regulator; Region: Rrf2; cl17282 568703001276 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703001277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568703001278 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568703001279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568703001280 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 568703001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001282 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001283 putative substrate translocation pore; other site 568703001284 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 568703001285 amidohydrolase; Region: amidohydrolases; TIGR01891 568703001286 putative metal binding site [ion binding]; other site 568703001287 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568703001288 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 568703001289 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703001290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001291 Walker A/P-loop; other site 568703001292 ATP binding site [chemical binding]; other site 568703001293 Q-loop/lid; other site 568703001294 ABC transporter signature motif; other site 568703001295 Walker B; other site 568703001296 D-loop; other site 568703001297 H-loop/switch region; other site 568703001298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703001299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703001300 substrate binding pocket [chemical binding]; other site 568703001301 membrane-bound complex binding site; other site 568703001302 hinge residues; other site 568703001303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001304 dimer interface [polypeptide binding]; other site 568703001305 conserved gate region; other site 568703001306 putative PBP binding loops; other site 568703001307 ABC-ATPase subunit interface; other site 568703001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001309 dimer interface [polypeptide binding]; other site 568703001310 conserved gate region; other site 568703001311 putative PBP binding loops; other site 568703001312 ABC-ATPase subunit interface; other site 568703001313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703001314 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 568703001315 DNA binding residues [nucleotide binding] 568703001316 YvrJ protein family; Region: YvrJ; pfam12841 568703001317 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 568703001318 active site 568703001319 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703001320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703001321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703001322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703001323 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703001324 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703001325 FtsX-like permease family; Region: FtsX; pfam02687 568703001326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703001327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703001328 Walker A/P-loop; other site 568703001329 ATP binding site [chemical binding]; other site 568703001330 Q-loop/lid; other site 568703001331 ABC transporter signature motif; other site 568703001332 Walker B; other site 568703001333 D-loop; other site 568703001334 H-loop/switch region; other site 568703001335 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703001336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703001337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703001338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001339 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703001340 active site 568703001341 motif I; other site 568703001342 motif II; other site 568703001343 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703001344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 568703001345 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 568703001346 active site 568703001347 NTP binding site [chemical binding]; other site 568703001348 metal binding triad [ion binding]; metal-binding site 568703001349 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 568703001350 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001351 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001352 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703001353 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568703001354 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568703001355 active site 568703001356 myosin-cross-reactive antigen; Provisional; Region: PRK13977 568703001357 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 568703001358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703001359 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 568703001360 DAK2 domain; Region: Dak2; cl03685 568703001361 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 568703001362 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568703001363 OsmC-like protein; Region: OsmC; cl00767 568703001364 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703001365 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001366 Walker A/P-loop; other site 568703001367 ATP binding site [chemical binding]; other site 568703001368 Q-loop/lid; other site 568703001369 ABC transporter signature motif; other site 568703001370 Walker B; other site 568703001371 D-loop; other site 568703001372 H-loop/switch region; other site 568703001373 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001374 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001376 non-specific DNA binding site [nucleotide binding]; other site 568703001377 salt bridge; other site 568703001378 sequence-specific DNA binding site [nucleotide binding]; other site 568703001379 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001380 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001381 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001382 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568703001383 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703001384 active site 568703001385 catalytic site [active] 568703001386 substrate binding site [chemical binding]; other site 568703001387 RelB antitoxin; Region: RelB; cl01171 568703001388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703001389 dimerization interface [polypeptide binding]; other site 568703001390 putative DNA binding site [nucleotide binding]; other site 568703001391 putative Zn2+ binding site [ion binding]; other site 568703001392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001393 benzoate transport; Region: 2A0115; TIGR00895 568703001394 putative substrate translocation pore; other site 568703001395 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568703001396 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568703001397 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001398 intersubunit interface [polypeptide binding]; other site 568703001399 active site 568703001400 zinc binding site [ion binding]; other site 568703001401 Na+ binding site [ion binding]; other site 568703001402 pyruvate oxidase; Provisional; Region: PRK08611 568703001403 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703001404 PYR/PP interface [polypeptide binding]; other site 568703001405 dimer interface [polypeptide binding]; other site 568703001406 tetramer interface [polypeptide binding]; other site 568703001407 TPP binding site [chemical binding]; other site 568703001408 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703001409 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703001410 TPP-binding site [chemical binding]; other site 568703001411 Beta-lactamase; Region: Beta-lactamase; cl17358 568703001412 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703001413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703001414 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568703001415 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 568703001416 active site 568703001417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568703001418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703001419 S-adenosylmethionine binding site [chemical binding]; other site 568703001420 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568703001421 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703001422 catalytic triad [active] 568703001423 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568703001424 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703001425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703001426 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703001427 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703001428 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703001429 DNA binding residues [nucleotide binding] 568703001430 putative dimer interface [polypeptide binding]; other site 568703001431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001433 active site 568703001434 catalytic tetrad [active] 568703001435 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001436 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001437 putative NAD(P) binding site [chemical binding]; other site 568703001438 dimer interface [polypeptide binding]; other site 568703001439 Predicted transcriptional regulators [Transcription]; Region: COG1733 568703001440 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568703001441 hypothetical protein; Provisional; Region: PRK10621 568703001442 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703001443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001444 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 568703001445 Walker A/P-loop; other site 568703001446 ATP binding site [chemical binding]; other site 568703001447 Q-loop/lid; other site 568703001448 ABC transporter signature motif; other site 568703001449 Walker B; other site 568703001450 D-loop; other site 568703001451 H-loop/switch region; other site 568703001452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001454 active site 568703001455 phosphorylation site [posttranslational modification] 568703001456 intermolecular recognition site; other site 568703001457 dimerization interface [polypeptide binding]; other site 568703001458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001459 DNA binding site [nucleotide binding] 568703001460 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 568703001461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703001463 dimerization interface [polypeptide binding]; other site 568703001464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001465 dimer interface [polypeptide binding]; other site 568703001466 phosphorylation site [posttranslational modification] 568703001467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001468 ATP binding site [chemical binding]; other site 568703001469 Mg2+ binding site [ion binding]; other site 568703001470 G-X-G motif; other site 568703001471 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001472 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 568703001473 Walker A/P-loop; other site 568703001474 ATP binding site [chemical binding]; other site 568703001475 Q-loop/lid; other site 568703001476 ABC transporter signature motif; other site 568703001477 Walker B; other site 568703001478 D-loop; other site 568703001479 H-loop/switch region; other site 568703001480 Peptidase family M1; Region: Peptidase_M1; pfam01433 568703001481 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 568703001482 Zn binding site [ion binding]; other site 568703001483 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 568703001484 inner membrane transporter YjeM; Provisional; Region: PRK15238 568703001485 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703001486 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568703001487 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 568703001488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001490 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 568703001491 putative dimerization interface [polypeptide binding]; other site 568703001492 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568703001493 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568703001494 classical (c) SDRs; Region: SDR_c; cd05233 568703001495 NAD(P) binding site [chemical binding]; other site 568703001496 active site 568703001497 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001498 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001499 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001500 shikimate binding site; other site 568703001501 NAD(P) binding site [chemical binding]; other site 568703001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001503 putative substrate translocation pore; other site 568703001504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703001505 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001506 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001507 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001508 shikimate binding site; other site 568703001509 NAD(P) binding site [chemical binding]; other site 568703001510 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 568703001511 proposed active site lysine [active] 568703001512 conserved cys residue [active] 568703001513 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568703001514 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568703001515 dimer interface [polypeptide binding]; other site 568703001516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001517 catalytic residue [active] 568703001518 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 568703001519 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568703001520 homodimer interface [polypeptide binding]; other site 568703001521 substrate-cofactor binding pocket; other site 568703001522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001523 catalytic residue [active] 568703001524 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703001525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703001526 substrate binding pocket [chemical binding]; other site 568703001527 membrane-bound complex binding site; other site 568703001528 hinge residues; other site 568703001529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001531 dimer interface [polypeptide binding]; other site 568703001532 conserved gate region; other site 568703001533 putative PBP binding loops; other site 568703001534 ABC-ATPase subunit interface; other site 568703001535 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703001536 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001537 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703001538 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703001539 legume lectins; Region: lectin_L-type; cd01951 568703001540 homotetramer interaction site [polypeptide binding]; other site 568703001541 homodimer interaction site [polypeptide binding]; other site 568703001542 carbohydrate binding site [chemical binding]; other site 568703001543 metal binding site [ion binding]; metal-binding site 568703001544 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001545 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001548 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001549 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001550 legume lectins; Region: lectin_L-type; cd01951 568703001551 homotetramer interaction site [polypeptide binding]; other site 568703001552 carbohydrate binding site [chemical binding]; other site 568703001553 metal binding site [ion binding]; metal-binding site 568703001554 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001555 EamA-like transporter family; Region: EamA; pfam00892 568703001556 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568703001557 EamA-like transporter family; Region: EamA; pfam00892 568703001558 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703001559 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703001560 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001561 Walker A/P-loop; other site 568703001562 ATP binding site [chemical binding]; other site 568703001563 Q-loop/lid; other site 568703001564 ABC transporter signature motif; other site 568703001565 Walker B; other site 568703001566 D-loop; other site 568703001567 H-loop/switch region; other site 568703001568 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 568703001569 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001570 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001571 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 568703001572 substrate binding site [chemical binding]; other site 568703001573 ATP binding site [chemical binding]; other site 568703001574 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 568703001575 FAD binding site [chemical binding]; other site 568703001576 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 568703001577 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 568703001578 THF binding site; other site 568703001579 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568703001580 substrate binding site [chemical binding]; other site 568703001581 THF binding site; other site 568703001582 zinc-binding site [ion binding]; other site 568703001583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001586 Walker A/P-loop; other site 568703001587 ATP binding site [chemical binding]; other site 568703001588 Q-loop/lid; other site 568703001589 ABC transporter signature motif; other site 568703001590 Walker B; other site 568703001591 D-loop; other site 568703001592 H-loop/switch region; other site 568703001593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001595 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568703001596 Walker A/P-loop; other site 568703001597 ATP binding site [chemical binding]; other site 568703001598 Q-loop/lid; other site 568703001599 ABC transporter signature motif; other site 568703001600 Walker B; other site 568703001601 D-loop; other site 568703001602 H-loop/switch region; other site 568703001603 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 568703001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001605 putative substrate translocation pore; other site 568703001606 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 568703001607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703001608 DNA-binding site [nucleotide binding]; DNA binding site 568703001609 UTRA domain; Region: UTRA; pfam07702 568703001610 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703001611 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703001612 Ca binding site [ion binding]; other site 568703001613 active site 568703001614 catalytic site [active] 568703001615 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 568703001616 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703001617 HPr interaction site; other site 568703001618 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703001619 active site 568703001620 phosphorylation site [posttranslational modification] 568703001621 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 568703001622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703001623 active site turn [active] 568703001624 phosphorylation site [posttranslational modification] 568703001625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703001626 serine/threonine transporter SstT; Provisional; Region: PRK13628 568703001627 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568703001628 amino acid transporter; Region: 2A0306; TIGR00909 568703001629 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 568703001630 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703001631 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703001632 NAD binding site [chemical binding]; other site 568703001633 dimer interface [polypeptide binding]; other site 568703001634 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703001635 substrate binding site [chemical binding]; other site 568703001636 glutamate dehydrogenase; Provisional; Region: PRK09414 568703001637 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568703001638 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 568703001639 NAD(P) binding site [chemical binding]; other site 568703001640 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703001641 DNA-binding site [nucleotide binding]; DNA binding site 568703001642 RNA-binding motif; other site 568703001643 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 568703001644 OsmC-like protein; Region: OsmC; pfam02566 568703001645 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703001646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001647 ABC transporter; Region: ABC_tran_2; pfam12848 568703001648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001649 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 568703001650 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703001651 NAD(P) binding site [chemical binding]; other site 568703001652 putative active site [active] 568703001653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001655 active site 568703001656 catalytic tetrad [active] 568703001657 putative transport protein YifK; Provisional; Region: PRK10746 568703001658 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 568703001659 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 568703001660 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 568703001661 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703001662 LytTr DNA-binding domain; Region: LytTR; smart00850 568703001663 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001665 Walker A/P-loop; other site 568703001666 ATP binding site [chemical binding]; other site 568703001667 Q-loop/lid; other site 568703001668 ABC transporter signature motif; other site 568703001669 Walker B; other site 568703001670 D-loop; other site 568703001671 H-loop/switch region; other site 568703001672 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703001673 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 568703001674 active site 568703001675 zinc binding site [ion binding]; other site 568703001676 hypothetical protein; Provisional; Region: PRK00967 568703001677 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 568703001678 nudix motif; other site 568703001679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001681 active site 568703001682 phosphorylation site [posttranslational modification] 568703001683 intermolecular recognition site; other site 568703001684 dimerization interface [polypeptide binding]; other site 568703001685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001686 DNA binding site [nucleotide binding] 568703001687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001689 dimer interface [polypeptide binding]; other site 568703001690 phosphorylation site [posttranslational modification] 568703001691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001692 ATP binding site [chemical binding]; other site 568703001693 Mg2+ binding site [ion binding]; other site 568703001694 G-X-G motif; other site 568703001695 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001697 Walker A/P-loop; other site 568703001698 ATP binding site [chemical binding]; other site 568703001699 Q-loop/lid; other site 568703001700 ABC transporter signature motif; other site 568703001701 Walker B; other site 568703001702 D-loop; other site 568703001703 H-loop/switch region; other site 568703001704 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 568703001705 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703001706 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703001707 putative NAD(P) binding site [chemical binding]; other site 568703001708 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 568703001709 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 568703001710 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 568703001711 MgtC family; Region: MgtC; pfam02308 568703001712 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 568703001713 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568703001714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001715 Walker A/P-loop; other site 568703001716 ATP binding site [chemical binding]; other site 568703001717 ABC transporter signature motif; other site 568703001718 Walker B; other site 568703001719 D-loop; other site 568703001720 H-loop/switch region; other site 568703001721 ABC transporter; Region: ABC_tran_2; pfam12848 568703001722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001724 Walker A/P-loop; other site 568703001725 ATP binding site [chemical binding]; other site 568703001726 Q-loop/lid; other site 568703001727 ABC transporter signature motif; other site 568703001728 Walker B; other site 568703001729 D-loop; other site 568703001730 H-loop/switch region; other site 568703001731 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 568703001732 putative uracil binding site [chemical binding]; other site 568703001733 putative active site [active] 568703001734 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 568703001735 amphipathic channel; other site 568703001736 Asn-Pro-Ala signature motifs; other site 568703001737 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 568703001738 glycerol kinase; Provisional; Region: glpK; PRK00047 568703001739 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703001740 N- and C-terminal domain interface [polypeptide binding]; other site 568703001741 active site 568703001742 MgATP binding site [chemical binding]; other site 568703001743 catalytic site [active] 568703001744 metal binding site [ion binding]; metal-binding site 568703001745 glycerol binding site [chemical binding]; other site 568703001746 homotetramer interface [polypeptide binding]; other site 568703001747 homodimer interface [polypeptide binding]; other site 568703001748 FBP binding site [chemical binding]; other site 568703001749 protein IIAGlc interface [polypeptide binding]; other site 568703001750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703001751 active site 568703001752 PRD domain; Region: PRD; pfam00874 568703001753 PRD domain; Region: PRD; pfam00874 568703001754 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 568703001755 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703001756 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 568703001757 active site 568703001758 P-loop; other site 568703001759 phosphorylation site [posttranslational modification] 568703001760 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703001761 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703001762 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703001763 methionine cluster; other site 568703001764 active site 568703001765 phosphorylation site [posttranslational modification] 568703001766 metal binding site [ion binding]; metal-binding site 568703001767 galactokinase; Provisional; Region: PRK05322 568703001768 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 568703001769 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703001770 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703001771 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 568703001772 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568703001773 NAD binding site [chemical binding]; other site 568703001774 homodimer interface [polypeptide binding]; other site 568703001775 active site 568703001776 substrate binding site [chemical binding]; other site 568703001777 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 568703001778 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 568703001779 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 568703001780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703001781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001782 DNA binding site [nucleotide binding] 568703001783 domain linker motif; other site 568703001784 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 568703001785 putative dimerization interface [polypeptide binding]; other site 568703001786 putative ligand binding site [chemical binding]; other site 568703001787 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 568703001788 active site 568703001789 catalytic residues [active] 568703001790 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703001791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703001792 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703001793 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703001794 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703001795 putative substrate binding site [chemical binding]; other site 568703001796 putative ATP binding site [chemical binding]; other site 568703001797 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 568703001798 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 568703001799 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 568703001800 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001801 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568703001802 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703001803 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 568703001804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001805 active site 568703001806 motif I; other site 568703001807 motif II; other site 568703001808 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 568703001809 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 568703001810 active site 568703001811 metal binding site [ion binding]; metal-binding site 568703001812 DNA binding site [nucleotide binding] 568703001813 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 568703001814 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 568703001815 AAA domain; Region: AAA_23; pfam13476 568703001816 Walker A/P-loop; other site 568703001817 ATP binding site [chemical binding]; other site 568703001818 Q-loop/lid; other site 568703001819 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 568703001820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001821 ABC transporter signature motif; other site 568703001822 Walker B; other site 568703001823 D-loop; other site 568703001824 H-loop/switch region; other site 568703001825 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703001826 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703001827 putative dimer interface [polypeptide binding]; other site 568703001828 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 568703001829 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703001830 minor groove reading motif; other site 568703001831 helix-hairpin-helix signature motif; other site 568703001832 substrate binding pocket [chemical binding]; other site 568703001833 active site 568703001834 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568703001835 DNA binding and oxoG recognition site [nucleotide binding] 568703001836 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703001837 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703001838 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 568703001839 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703001840 dimer interface [polypeptide binding]; other site 568703001841 substrate binding site [chemical binding]; other site 568703001842 ATP binding site [chemical binding]; other site 568703001843 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703001844 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703001845 NAD binding site [chemical binding]; other site 568703001846 substrate binding site [chemical binding]; other site 568703001847 putative active site [active] 568703001848 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 568703001849 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568703001850 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 568703001851 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 568703001852 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001853 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568703001854 zinc binding site [ion binding]; other site 568703001855 putative ligand binding site [chemical binding]; other site 568703001856 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001857 zinc binding site [ion binding]; other site 568703001858 putative ligand binding site [chemical binding]; other site 568703001859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703001860 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703001861 TM-ABC transporter signature motif; other site 568703001862 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703001863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001864 Walker A/P-loop; other site 568703001865 ATP binding site [chemical binding]; other site 568703001866 Q-loop/lid; other site 568703001867 ABC transporter signature motif; other site 568703001868 Walker B; other site 568703001869 D-loop; other site 568703001870 H-loop/switch region; other site 568703001871 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 568703001872 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568703001873 NADP binding site [chemical binding]; other site 568703001874 dimer interface [polypeptide binding]; other site 568703001875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001876 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 568703001877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001878 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703001879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001880 motif II; other site 568703001881 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001882 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703001883 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703001884 Ligand binding site; other site 568703001885 Putative Catalytic site; other site 568703001886 DXD motif; other site 568703001887 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568703001888 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 568703001889 Predicted membrane protein [Function unknown]; Region: COG2246 568703001890 GtrA-like protein; Region: GtrA; pfam04138 568703001891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001893 active site 568703001894 phosphorylation site [posttranslational modification] 568703001895 intermolecular recognition site; other site 568703001896 dimerization interface [polypeptide binding]; other site 568703001897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001898 DNA binding site [nucleotide binding] 568703001899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001901 dimer interface [polypeptide binding]; other site 568703001902 phosphorylation site [posttranslational modification] 568703001903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001904 ATP binding site [chemical binding]; other site 568703001905 Mg2+ binding site [ion binding]; other site 568703001906 G-X-G motif; other site 568703001907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 568703001908 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 568703001909 hypothetical protein; Provisional; Region: PRK06194 568703001910 classical (c) SDRs; Region: SDR_c; cd05233 568703001911 NAD(P) binding site [chemical binding]; other site 568703001912 active site 568703001913 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 568703001914 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703001915 dimer interface [polypeptide binding]; other site 568703001916 FMN binding site [chemical binding]; other site 568703001917 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568703001918 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 568703001919 phosphate binding site [ion binding]; other site 568703001920 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703001921 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703001922 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 568703001923 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001924 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001925 putative NAD(P) binding site [chemical binding]; other site 568703001926 dimer interface [polypeptide binding]; other site 568703001927 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703001928 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568703001929 LexA repressor; Validated; Region: PRK00215 568703001930 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 568703001931 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568703001932 Catalytic site [active] 568703001933 Membrane transport protein; Region: Mem_trans; pfam03547 568703001934 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 568703001935 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 568703001936 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 568703001937 Uncharacterized conserved protein [Function unknown]; Region: COG3189 568703001938 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 568703001939 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 568703001940 Cl binding site [ion binding]; other site 568703001941 oligomer interface [polypeptide binding]; other site 568703001942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001944 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 568703001945 putative dimerization interface [polypeptide binding]; other site 568703001946 malate dehydrogenase; Provisional; Region: PRK13529 568703001947 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703001948 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 568703001949 NAD(P) binding site [chemical binding]; other site 568703001950 Membrane transport protein; Region: Mem_trans; cl09117 568703001951 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 568703001952 dimer interface [polypeptide binding]; other site 568703001953 catalytic triad [active] 568703001954 peroxidatic and resolving cysteines [active] 568703001955 Flavodoxin domain; Region: Flavodoxin_5; cl17428 568703001956 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703001957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001958 non-specific DNA binding site [nucleotide binding]; other site 568703001959 salt bridge; other site 568703001960 sequence-specific DNA binding site [nucleotide binding]; other site 568703001961 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001964 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703001965 Walker A/P-loop; other site 568703001966 ATP binding site [chemical binding]; other site 568703001967 Q-loop/lid; other site 568703001968 ABC transporter signature motif; other site 568703001969 Walker B; other site 568703001970 D-loop; other site 568703001971 H-loop/switch region; other site 568703001972 oligoendopeptidase F; Region: pepF; TIGR00181 568703001973 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 568703001974 active site 568703001975 Zn binding site [ion binding]; other site 568703001976 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568703001977 active site 568703001978 multimer interface [polypeptide binding]; other site 568703001979 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001980 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 568703001981 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703001982 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703001983 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703001984 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568703001985 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703001986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001987 motif II; other site 568703001988 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 568703001989 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703001990 MarR family; Region: MarR_2; pfam12802 568703001991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703001992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568703001993 flavoprotein NrdI; Provisional; Region: PRK02551 568703001994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001995 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001996 active site 568703001997 catalytic tetrad [active] 568703001998 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703001999 Predicted membrane protein [Function unknown]; Region: COG2323 568703002000 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 568703002001 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568703002002 substrate binding site [chemical binding]; other site 568703002003 zinc-binding site [ion binding]; other site 568703002004 S-ribosylhomocysteinase; Provisional; Region: PRK02260 568703002005 Uncharacterized conserved protein [Function unknown]; Region: COG0398 568703002006 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568703002007 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568703002008 RuvA N terminal domain; Region: RuvA_N; pfam01330 568703002009 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568703002010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703002011 Walker A motif; other site 568703002012 ATP binding site [chemical binding]; other site 568703002013 Walker B motif; other site 568703002014 arginine finger; other site 568703002015 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568703002016 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568703002017 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568703002018 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568703002019 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 568703002020 Preprotein translocase subunit; Region: YajC; pfam02699 568703002021 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 568703002022 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 568703002023 putative catalytic cysteine [active] 568703002024 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 568703002025 putative active site [active] 568703002026 metal binding site [ion binding]; metal-binding site 568703002027 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 568703002028 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 568703002029 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 568703002030 FeoA domain; Region: FeoA; pfam04023 568703002031 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568703002032 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568703002033 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568703002034 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568703002035 active site 568703002036 DNA polymerase IV; Validated; Region: PRK02406 568703002037 DNA binding site [nucleotide binding] 568703002038 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 568703002039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703002040 DNA-binding site [nucleotide binding]; DNA binding site 568703002041 DRTGG domain; Region: DRTGG; pfam07085 568703002042 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703002043 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703002044 DHH family; Region: DHH; pfam01368 568703002045 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703002046 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568703002047 ATP binding site [chemical binding]; other site 568703002048 Mg++ binding site [ion binding]; other site 568703002049 motif III; other site 568703002050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002051 nucleotide binding region [chemical binding]; other site 568703002052 ATP-binding site [chemical binding]; other site 568703002053 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568703002054 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568703002055 motif 1; other site 568703002056 active site 568703002057 motif 2; other site 568703002058 motif 3; other site 568703002059 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568703002060 DHHA1 domain; Region: DHHA1; pfam02272 568703002061 hypothetical protein; Provisional; Region: PRK05473 568703002062 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 568703002063 hypothetical protein; Provisional; Region: PRK13678 568703002064 Cell division protein ZapA; Region: ZapA; pfam05164 568703002065 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568703002066 Colicin V production protein; Region: Colicin_V; pfam02674 568703002067 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 568703002068 MutS domain III; Region: MutS_III; pfam05192 568703002069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002070 Walker A/P-loop; other site 568703002071 ATP binding site [chemical binding]; other site 568703002072 Q-loop/lid; other site 568703002073 ABC transporter signature motif; other site 568703002074 Walker B; other site 568703002075 D-loop; other site 568703002076 H-loop/switch region; other site 568703002077 Smr domain; Region: Smr; pfam01713 568703002078 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703002079 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568703002080 catalytic residues [active] 568703002081 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 568703002082 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 568703002083 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 568703002084 acyl-activating enzyme (AAE) consensus motif; other site 568703002085 AMP binding site [chemical binding]; other site 568703002086 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 568703002087 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 568703002088 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 568703002089 DltD N-terminal region; Region: DltD_N; pfam04915 568703002090 DltD central region; Region: DltD_M; pfam04918 568703002091 DltD C-terminal region; Region: DltD_C; pfam04914 568703002092 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 568703002093 glutamate racemase; Provisional; Region: PRK00865 568703002094 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 568703002095 active site 568703002096 dimerization interface [polypeptide binding]; other site 568703002097 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 568703002098 active site 568703002099 metal binding site [ion binding]; metal-binding site 568703002100 homotetramer interface [polypeptide binding]; other site 568703002101 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568703002102 amphipathic channel; other site 568703002103 Asn-Pro-Ala signature motifs; other site 568703002104 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 568703002105 FOG: CBS domain [General function prediction only]; Region: COG0517 568703002106 Domain of unknown function (DUF368); Region: DUF368; pfam04018 568703002107 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568703002108 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568703002109 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 568703002110 YtxH-like protein; Region: YtxH; pfam12732 568703002111 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 568703002112 HTH domain; Region: HTH_11; pfam08279 568703002113 3H domain; Region: 3H; pfam02829 568703002114 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703002115 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703002116 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703002117 active site 568703002118 catabolite control protein A; Region: ccpA; TIGR01481 568703002119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703002120 DNA binding site [nucleotide binding] 568703002121 domain linker motif; other site 568703002122 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 568703002123 dimerization interface [polypeptide binding]; other site 568703002124 effector binding site; other site 568703002125 Transglycosylase; Region: Transgly; pfam00912 568703002126 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703002127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568703002128 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 568703002129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002130 motif II; other site 568703002131 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 568703002132 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568703002133 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568703002134 dipeptidase PepV; Reviewed; Region: PRK07318 568703002135 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703002136 active site 568703002137 metal binding site [ion binding]; metal-binding site 568703002138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703002139 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 568703002140 active site 568703002141 catalytic site [active] 568703002142 metal binding site [ion binding]; metal-binding site 568703002143 YibE/F-like protein; Region: YibE_F; pfam07907 568703002144 YibE/F-like protein; Region: YibE_F; cl02259 568703002145 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 568703002146 putative active site [active] 568703002147 putative metal binding site [ion binding]; other site 568703002148 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 568703002149 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703002150 active site 568703002151 metal binding site [ion binding]; metal-binding site 568703002152 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703002153 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 568703002154 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 568703002155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002156 active site 568703002157 motif I; other site 568703002158 motif II; other site 568703002159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002160 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 568703002161 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568703002162 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568703002163 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568703002164 tetramer interfaces [polypeptide binding]; other site 568703002165 binuclear metal-binding site [ion binding]; other site 568703002166 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568703002167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703002168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703002169 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 568703002170 active site 568703002171 general stress protein 13; Validated; Region: PRK08059 568703002172 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 568703002173 RNA binding site [nucleotide binding]; other site 568703002174 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 568703002175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703002176 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703002177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002178 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 568703002179 putative ADP-binding pocket [chemical binding]; other site 568703002180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703002182 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 568703002183 aromatic amino acid aminotransferase; Validated; Region: PRK07309 568703002184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002186 homodimer interface [polypeptide binding]; other site 568703002187 catalytic residue [active] 568703002188 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 568703002189 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002190 Sulfatase; Region: Sulfatase; pfam00884 568703002191 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703002192 metal binding site 2 [ion binding]; metal-binding site 568703002193 putative DNA binding helix; other site 568703002194 metal binding site 1 [ion binding]; metal-binding site 568703002195 dimer interface [polypeptide binding]; other site 568703002196 structural Zn2+ binding site [ion binding]; other site 568703002197 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568703002198 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568703002199 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568703002200 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568703002201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002203 putative substrate translocation pore; other site 568703002204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002205 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703002206 DNA binding residues [nucleotide binding] 568703002207 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703002208 putative dimer interface [polypeptide binding]; other site 568703002209 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703002210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002211 putative substrate translocation pore; other site 568703002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002213 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 568703002214 active site 568703002215 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568703002216 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002217 HIGH motif; other site 568703002218 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703002219 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002220 active site 568703002221 KMSKS motif; other site 568703002222 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568703002223 tRNA binding surface [nucleotide binding]; other site 568703002224 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703002225 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 568703002226 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703002227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002228 RNA binding surface [nucleotide binding]; other site 568703002229 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 568703002230 active site 568703002231 uracil binding [chemical binding]; other site 568703002232 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 568703002233 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568703002234 putative substrate binding site [chemical binding]; other site 568703002235 putative ATP binding site [chemical binding]; other site 568703002236 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 568703002237 nudix motif; other site 568703002238 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 568703002239 catalytic residues [active] 568703002240 dimer interface [polypeptide binding]; other site 568703002241 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 568703002242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002244 homodimer interface [polypeptide binding]; other site 568703002245 catalytic residue [active] 568703002246 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 568703002247 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703002248 active site 568703002249 metal binding site [ion binding]; metal-binding site 568703002250 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568703002251 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 568703002252 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 568703002253 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 568703002254 Competence protein CoiA-like family; Region: CoiA; cl11541 568703002255 Thioredoxin; Region: Thioredoxin_5; pfam13743 568703002256 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 568703002257 putative active site [active] 568703002258 putative metal binding residues [ion binding]; other site 568703002259 signature motif; other site 568703002260 putative triphosphate binding site [ion binding]; other site 568703002261 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703002262 synthetase active site [active] 568703002263 NTP binding site [chemical binding]; other site 568703002264 metal binding site [ion binding]; metal-binding site 568703002265 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 568703002266 ATP-NAD kinase; Region: NAD_kinase; pfam01513 568703002267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002268 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703002269 RNA binding surface [nucleotide binding]; other site 568703002270 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703002271 active site 568703002272 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703002273 ApbE family; Region: ApbE; pfam02424 568703002274 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 568703002275 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 568703002276 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 568703002277 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 568703002278 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568703002279 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 568703002280 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568703002281 active site 568703002282 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568703002283 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 568703002284 Cl binding site [ion binding]; other site 568703002285 oligomer interface [polypeptide binding]; other site 568703002286 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 568703002287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002288 S-adenosylmethionine binding site [chemical binding]; other site 568703002289 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 568703002290 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 568703002291 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568703002292 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703002293 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 568703002294 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002295 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002296 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002297 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568703002298 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002299 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568703002300 classical (c) SDRs; Region: SDR_c; cd05233 568703002301 NAD(P) binding site [chemical binding]; other site 568703002302 active site 568703002303 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 568703002304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002305 non-specific DNA binding site [nucleotide binding]; other site 568703002306 salt bridge; other site 568703002307 sequence-specific DNA binding site [nucleotide binding]; other site 568703002308 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 568703002309 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568703002310 competence damage-inducible protein A; Provisional; Region: PRK00549 568703002311 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568703002312 putative MPT binding site; other site 568703002313 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 568703002314 recombinase A; Provisional; Region: recA; PRK09354 568703002315 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703002316 hexamer interface [polypeptide binding]; other site 568703002317 Walker A motif; other site 568703002318 ATP binding site [chemical binding]; other site 568703002319 Walker B motif; other site 568703002320 ribonuclease Y; Region: RNase_Y; TIGR03319 568703002321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703002322 Zn2+ binding site [ion binding]; other site 568703002323 Mg2+ binding site [ion binding]; other site 568703002324 Uncharacterized conserved protein [Function unknown]; Region: COG1739 568703002325 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568703002326 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568703002327 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 568703002328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002329 ATP binding site [chemical binding]; other site 568703002330 putative Mg++ binding site [ion binding]; other site 568703002331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002332 nucleotide binding region [chemical binding]; other site 568703002333 ATP-binding site [chemical binding]; other site 568703002334 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 568703002335 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568703002336 30S subunit binding site; other site 568703002337 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 568703002338 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568703002339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002340 nucleotide binding region [chemical binding]; other site 568703002341 ATP-binding site [chemical binding]; other site 568703002342 peptide chain release factor 2; Provisional; Region: PRK05589 568703002343 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568703002344 RF-1 domain; Region: RF-1; pfam00472 568703002345 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 568703002346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002347 Walker A/P-loop; other site 568703002348 ATP binding site [chemical binding]; other site 568703002349 Q-loop/lid; other site 568703002350 ABC transporter signature motif; other site 568703002351 Walker B; other site 568703002352 D-loop; other site 568703002353 H-loop/switch region; other site 568703002354 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 568703002355 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 568703002356 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568703002357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703002359 active site 568703002360 phosphorylation site [posttranslational modification] 568703002361 intermolecular recognition site; other site 568703002362 dimerization interface [polypeptide binding]; other site 568703002363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703002364 DNA binding site [nucleotide binding] 568703002365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 568703002366 PAS domain; Region: PAS_8; pfam13188 568703002367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703002368 dimer interface [polypeptide binding]; other site 568703002369 phosphorylation site [posttranslational modification] 568703002370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002371 ATP binding site [chemical binding]; other site 568703002372 Mg2+ binding site [ion binding]; other site 568703002373 G-X-G motif; other site 568703002374 phosphate binding protein; Region: ptsS_2; TIGR02136 568703002375 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568703002376 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 568703002377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002378 dimer interface [polypeptide binding]; other site 568703002379 conserved gate region; other site 568703002380 putative PBP binding loops; other site 568703002381 ABC-ATPase subunit interface; other site 568703002382 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 568703002383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002384 dimer interface [polypeptide binding]; other site 568703002385 conserved gate region; other site 568703002386 putative PBP binding loops; other site 568703002387 ABC-ATPase subunit interface; other site 568703002388 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 568703002389 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568703002390 Walker A/P-loop; other site 568703002391 ATP binding site [chemical binding]; other site 568703002392 Q-loop/lid; other site 568703002393 ABC transporter signature motif; other site 568703002394 Walker B; other site 568703002395 D-loop; other site 568703002396 H-loop/switch region; other site 568703002397 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 568703002398 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568703002399 Walker A/P-loop; other site 568703002400 ATP binding site [chemical binding]; other site 568703002401 Q-loop/lid; other site 568703002402 ABC transporter signature motif; other site 568703002403 Walker B; other site 568703002404 D-loop; other site 568703002405 H-loop/switch region; other site 568703002406 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 568703002407 PhoU domain; Region: PhoU; pfam01895 568703002408 PhoU domain; Region: PhoU; pfam01895 568703002409 HTH-like domain; Region: HTH_21; pfam13276 568703002410 Integrase core domain; Region: rve; pfam00665 568703002411 Integrase core domain; Region: rve_3; pfam13683 568703002412 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703002413 Transposase; Region: HTH_Tnp_1; cl17663 568703002414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703002415 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703002416 Uncharacterized conserved protein [Function unknown]; Region: COG3595 568703002417 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 568703002418 Membrane protein of unknown function; Region: DUF360; pfam04020 568703002419 HPr kinase/phosphorylase; Provisional; Region: PRK05428 568703002420 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 568703002421 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 568703002422 Hpr binding site; other site 568703002423 active site 568703002424 homohexamer subunit interaction site [polypeptide binding]; other site 568703002425 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 568703002426 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568703002427 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568703002428 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568703002429 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 568703002430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703002431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703002432 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 568703002433 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 568703002434 active site 568703002435 substrate binding site [chemical binding]; other site 568703002436 metal binding site [ion binding]; metal-binding site 568703002437 HD domain; Region: HD_3; cl17350 568703002438 excinuclease ABC subunit B; Provisional; Region: PRK05298 568703002439 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 568703002440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002441 ATP-binding site [chemical binding]; other site 568703002442 ATP binding site [chemical binding]; other site 568703002443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002444 nucleotide binding region [chemical binding]; other site 568703002445 ATP-binding site [chemical binding]; other site 568703002446 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568703002447 UvrB/uvrC motif; Region: UVR; pfam02151 568703002448 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568703002449 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568703002450 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568703002451 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568703002452 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 568703002453 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 568703002454 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 568703002455 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 568703002456 phosphate binding site [ion binding]; other site 568703002457 putative substrate binding pocket [chemical binding]; other site 568703002458 dimer interface [polypeptide binding]; other site 568703002459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 568703002460 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 568703002461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703002462 MarR family; Region: MarR; pfam01047 568703002463 Clp protease; Region: CLP_protease; pfam00574 568703002464 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568703002465 oligomer interface [polypeptide binding]; other site 568703002466 active site residues [active] 568703002467 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568703002468 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 568703002469 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 568703002470 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568703002471 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 568703002472 Phosphoglycerate kinase; Region: PGK; pfam00162 568703002473 substrate binding site [chemical binding]; other site 568703002474 hinge regions; other site 568703002475 ADP binding site [chemical binding]; other site 568703002476 catalytic site [active] 568703002477 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568703002478 triosephosphate isomerase; Provisional; Region: PRK14567 568703002479 substrate binding site [chemical binding]; other site 568703002480 dimer interface [polypeptide binding]; other site 568703002481 catalytic triad [active] 568703002482 enolase; Provisional; Region: eno; PRK00077 568703002483 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568703002484 dimer interface [polypeptide binding]; other site 568703002485 metal binding site [ion binding]; metal-binding site 568703002486 substrate binding pocket [chemical binding]; other site 568703002487 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 568703002488 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568703002489 Cl- selectivity filter; other site 568703002490 Cl- binding residues [ion binding]; other site 568703002491 pore gating glutamate residue; other site 568703002492 dimer interface [polypeptide binding]; other site 568703002493 H+/Cl- coupling transport residue; other site 568703002494 TrkA-C domain; Region: TrkA_C; pfam02080 568703002495 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 568703002496 Esterase/lipase [General function prediction only]; Region: COG1647 568703002497 ribonuclease R; Region: RNase_R; TIGR02063 568703002498 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568703002499 RNB domain; Region: RNB; pfam00773 568703002500 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 568703002501 RNA binding site [nucleotide binding]; other site 568703002502 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568703002503 SmpB-tmRNA interface; other site 568703002504 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 568703002505 homodimer interface [polypeptide binding]; other site 568703002506 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 568703002507 active site 568703002508 homodimer interface [polypeptide binding]; other site 568703002509 catalytic site [active] 568703002510 maltose phosphorylase; Provisional; Region: PRK13807 568703002511 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 568703002512 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 568703002513 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 568703002514 beta-phosphoglucomutase; Region: bPGM; TIGR01990 568703002515 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703002516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002517 motif II; other site 568703002518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002519 sequence-specific DNA binding site [nucleotide binding]; other site 568703002520 salt bridge; other site 568703002521 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703002522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703002523 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703002524 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703002525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703002526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703002527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703002528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002529 dimer interface [polypeptide binding]; other site 568703002530 conserved gate region; other site 568703002531 putative PBP binding loops; other site 568703002532 ABC-ATPase subunit interface; other site 568703002533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002534 dimer interface [polypeptide binding]; other site 568703002535 conserved gate region; other site 568703002536 putative PBP binding loops; other site 568703002537 ABC-ATPase subunit interface; other site 568703002538 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568703002539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002540 Walker A/P-loop; other site 568703002541 ATP binding site [chemical binding]; other site 568703002542 Q-loop/lid; other site 568703002543 ABC transporter signature motif; other site 568703002544 Walker B; other site 568703002545 D-loop; other site 568703002546 H-loop/switch region; other site 568703002547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002548 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703002549 Coenzyme A binding pocket [chemical binding]; other site 568703002550 Tubby C 2; Region: Tub_2; cl02043 568703002551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002552 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002553 active site 568703002554 motif I; other site 568703002555 motif II; other site 568703002556 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568703002557 ligand binding site [chemical binding]; other site 568703002558 active site 568703002559 UGI interface [polypeptide binding]; other site 568703002560 catalytic site [active] 568703002561 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 568703002562 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 568703002563 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703002564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002565 Walker A/P-loop; other site 568703002566 ATP binding site [chemical binding]; other site 568703002567 Q-loop/lid; other site 568703002568 ABC transporter signature motif; other site 568703002569 Walker B; other site 568703002570 D-loop; other site 568703002571 H-loop/switch region; other site 568703002572 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 568703002573 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002574 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 568703002575 active site 568703002576 catalytic site [active] 568703002577 substrate binding site [chemical binding]; other site 568703002578 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 568703002579 active site 568703002580 putative catalytic site [active] 568703002581 DNA binding site [nucleotide binding] 568703002582 putative phosphate binding site [ion binding]; other site 568703002583 metal binding site A [ion binding]; metal-binding site 568703002584 AP binding site [nucleotide binding]; other site 568703002585 metal binding site B [ion binding]; metal-binding site 568703002586 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703002587 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 568703002588 FAD binding domain; Region: FAD_binding_4; pfam01565 568703002589 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568703002590 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 568703002591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703002592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002593 non-specific DNA binding site [nucleotide binding]; other site 568703002594 salt bridge; other site 568703002595 sequence-specific DNA binding site [nucleotide binding]; other site 568703002596 Cupin domain; Region: Cupin_2; pfam07883 568703002597 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568703002598 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 568703002599 Walker A/P-loop; other site 568703002600 ATP binding site [chemical binding]; other site 568703002601 Q-loop/lid; other site 568703002602 ABC transporter signature motif; other site 568703002603 Walker B; other site 568703002604 D-loop; other site 568703002605 H-loop/switch region; other site 568703002606 TOBE domain; Region: TOBE_2; pfam08402 568703002607 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002609 dimer interface [polypeptide binding]; other site 568703002610 conserved gate region; other site 568703002611 putative PBP binding loops; other site 568703002612 ABC-ATPase subunit interface; other site 568703002613 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002615 dimer interface [polypeptide binding]; other site 568703002616 conserved gate region; other site 568703002617 putative PBP binding loops; other site 568703002618 ABC-ATPase subunit interface; other site 568703002619 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568703002620 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703002621 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703002622 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703002623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703002624 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703002625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002626 motif II; other site 568703002627 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703002628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002630 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002631 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568703002632 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568703002633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703002634 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 568703002635 Walker A/P-loop; other site 568703002636 ATP binding site [chemical binding]; other site 568703002637 Q-loop/lid; other site 568703002638 ABC transporter signature motif; other site 568703002639 Walker B; other site 568703002640 D-loop; other site 568703002641 H-loop/switch region; other site 568703002642 Uncharacterized conserved protein [Function unknown]; Region: COG1624 568703002643 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 568703002644 YbbR-like protein; Region: YbbR; pfam07949 568703002645 YbbR-like protein; Region: YbbR; pfam07949 568703002646 YbbR-like protein; Region: YbbR; pfam07949 568703002647 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 568703002648 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568703002649 active site 568703002650 substrate binding site [chemical binding]; other site 568703002651 metal binding site [ion binding]; metal-binding site 568703002652 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568703002653 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568703002654 glutaminase active site [active] 568703002655 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703002656 dimer interface [polypeptide binding]; other site 568703002657 active site 568703002658 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568703002659 dimer interface [polypeptide binding]; other site 568703002660 active site 568703002661 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 568703002662 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 568703002663 active site 568703002664 Zn binding site [ion binding]; other site 568703002665 Predicted integral membrane protein [Function unknown]; Region: COG5652 568703002666 hypothetical protein; Validated; Region: PRK00110 568703002667 Type II/IV secretion system protein; Region: T2SE; pfam00437 568703002668 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568703002669 Walker A motif; other site 568703002670 ATP binding site [chemical binding]; other site 568703002671 Walker B motif; other site 568703002672 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568703002673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568703002674 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 568703002675 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 568703002676 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 568703002677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002678 S-adenosylmethionine binding site [chemical binding]; other site 568703002679 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 568703002680 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703002681 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 568703002682 putative acyl-acceptor binding pocket; other site 568703002683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703002684 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 568703002685 active site 568703002686 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568703002687 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 568703002688 Ligand binding site; other site 568703002689 metal-binding site 568703002690 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703002691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703002692 putative acyl-acceptor binding pocket; other site 568703002693 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703002694 Melibiase; Region: Melibiase; pfam02065 568703002695 SdpI/YhfL protein family; Region: SdpI; pfam13630 568703002696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703002698 active site 568703002699 phosphorylation site [posttranslational modification] 568703002700 intermolecular recognition site; other site 568703002701 dimerization interface [polypeptide binding]; other site 568703002702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703002703 DNA binding site [nucleotide binding] 568703002704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703002705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703002706 dimerization interface [polypeptide binding]; other site 568703002707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703002708 dimer interface [polypeptide binding]; other site 568703002709 phosphorylation site [posttranslational modification] 568703002710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002711 ATP binding site [chemical binding]; other site 568703002712 Mg2+ binding site [ion binding]; other site 568703002713 G-X-G motif; other site 568703002714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703002715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002716 Coenzyme A binding pocket [chemical binding]; other site 568703002717 hypothetical protein; Provisional; Region: PRK04435 568703002718 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 568703002719 DNA-binding interface [nucleotide binding]; DNA binding site 568703002720 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 568703002721 DNA polymerase IV; Reviewed; Region: PRK03103 568703002722 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 568703002723 active site 568703002724 DNA binding site [nucleotide binding] 568703002725 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 568703002726 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568703002727 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 568703002728 active site 568703002729 catalytic triad [active] 568703002730 oxyanion hole [active] 568703002731 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 568703002732 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 568703002733 Part of AAA domain; Region: AAA_19; pfam13245 568703002734 Family description; Region: UvrD_C_2; pfam13538 568703002735 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568703002736 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568703002737 nucleotide binding pocket [chemical binding]; other site 568703002738 K-X-D-G motif; other site 568703002739 catalytic site [active] 568703002740 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568703002741 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568703002742 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568703002743 Dimer interface [polypeptide binding]; other site 568703002744 BRCT sequence motif; other site 568703002745 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 568703002746 putative dimer interface [polypeptide binding]; other site 568703002747 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 568703002748 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 568703002749 putative dimer interface [polypeptide binding]; other site 568703002750 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 568703002751 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568703002752 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 568703002753 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 568703002754 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 568703002755 GatB domain; Region: GatB_Yqey; smart00845 568703002756 putative lipid kinase; Reviewed; Region: PRK13055 568703002757 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703002758 TRAM domain; Region: TRAM; pfam01938 568703002759 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703002760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002761 S-adenosylmethionine binding site [chemical binding]; other site 568703002762 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 568703002763 DNA methylase; Region: N6_N4_Mtase; pfam01555 568703002764 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703002765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703002766 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703002767 DNA methylase; Region: N6_N4_Mtase; cl17433 568703002768 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 568703002769 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 568703002770 Transposase domain (DUF772); Region: DUF772; pfam05598 568703002771 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703002772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002773 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002774 putative substrate translocation pore; other site 568703002775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002776 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002777 active site 568703002778 motif I; other site 568703002779 motif II; other site 568703002780 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703002781 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 568703002782 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703002783 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703002784 active site 568703002785 Zn binding site [ion binding]; other site 568703002786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002787 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703002788 Coenzyme A binding pocket [chemical binding]; other site 568703002789 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703002790 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703002791 HflC protein; Region: hflC; TIGR01932 568703002792 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568703002793 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 568703002794 active site 568703002795 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002796 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703002797 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002798 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703002799 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703002800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568703002801 ATP binding site [chemical binding]; other site 568703002802 putative Mg++ binding site [ion binding]; other site 568703002803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002804 nucleotide binding region [chemical binding]; other site 568703002805 ATP-binding site [chemical binding]; other site 568703002806 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703002807 active site 568703002808 methionine cluster; other site 568703002809 phosphorylation site [posttranslational modification] 568703002810 metal binding site [ion binding]; metal-binding site 568703002811 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703002812 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703002813 active site 568703002814 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 568703002815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002816 ATP binding site [chemical binding]; other site 568703002817 putative Mg++ binding site [ion binding]; other site 568703002818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002819 nucleotide binding region [chemical binding]; other site 568703002820 ATP-binding site [chemical binding]; other site 568703002821 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 568703002822 HRDC domain; Region: HRDC; pfam00570 568703002823 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 568703002824 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 568703002825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002827 WHG domain; Region: WHG; pfam13305 568703002828 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 568703002829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 568703002830 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 568703002831 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568703002832 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568703002833 active site 568703002834 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703002835 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703002836 active site 568703002837 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 568703002838 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 568703002839 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 568703002840 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703002841 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568703002842 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568703002843 active site 568703002844 tetramer interface; other site 568703002845 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703002846 beta-galactosidase; Region: BGL; TIGR03356 568703002847 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703002848 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703002849 active site turn [active] 568703002850 phosphorylation site [posttranslational modification] 568703002851 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703002852 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703002853 HPr interaction site; other site 568703002854 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703002855 active site 568703002856 phosphorylation site [posttranslational modification] 568703002857 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002858 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002859 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703002860 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703002861 Ligand binding site; other site 568703002862 Putative Catalytic site; other site 568703002863 DXD motif; other site 568703002864 Predicted membrane protein [Function unknown]; Region: COG4129 568703002865 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 568703002866 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 568703002867 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703002868 DNA-binding site [nucleotide binding]; DNA binding site 568703002869 RNA-binding motif; other site 568703002870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703002871 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 568703002872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703002873 active site 568703002874 xanthine permease; Region: pbuX; TIGR03173 568703002875 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 568703002876 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703002877 adenylosuccinate lyase; Provisional; Region: PRK07492 568703002878 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 568703002879 tetramer interface [polypeptide binding]; other site 568703002880 active site 568703002881 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002882 Sulfatase; Region: Sulfatase; pfam00884 568703002883 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 568703002884 Sugar transport protein; Region: Sugar_transport; pfam06800 568703002885 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 568703002886 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568703002887 active site 568703002888 dimer interface [polypeptide binding]; other site 568703002889 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568703002890 dimer interface [polypeptide binding]; other site 568703002891 active site 568703002892 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568703002893 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703002894 Int/Topo IB signature motif; other site 568703002895 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568703002896 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 568703002897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703002898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002899 non-specific DNA binding site [nucleotide binding]; other site 568703002900 salt bridge; other site 568703002901 sequence-specific DNA binding site [nucleotide binding]; other site 568703002902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002903 non-specific DNA binding site [nucleotide binding]; other site 568703002904 salt bridge; other site 568703002905 sequence-specific DNA binding site [nucleotide binding]; other site 568703002906 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 568703002907 Helix-turn-helix domain; Region: HTH_17; cl17695 568703002908 RecT family; Region: RecT; pfam03837 568703002909 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 568703002910 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 568703002911 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703002912 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703002913 dimer interface [polypeptide binding]; other site 568703002914 ssDNA binding site [nucleotide binding]; other site 568703002915 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703002916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002917 non-specific DNA binding site [nucleotide binding]; other site 568703002918 salt bridge; other site 568703002919 sequence-specific DNA binding site [nucleotide binding]; other site 568703002920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002921 non-specific DNA binding site [nucleotide binding]; other site 568703002922 salt bridge; other site 568703002923 sequence-specific DNA binding site [nucleotide binding]; other site 568703002924 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 568703002925 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 568703002926 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 568703002927 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 568703002928 GcrA cell cycle regulator; Region: GcrA; cl11564 568703002929 NUMOD4 motif; Region: NUMOD4; pfam07463 568703002930 HNH endonuclease; Region: HNH_3; pfam13392 568703002931 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703002932 Terminase small subunit; Region: Terminase_2; pfam03592 568703002933 Phage terminase large subunit; Region: Terminase_3; cl12054 568703002934 Terminase-like family; Region: Terminase_6; pfam03237 568703002935 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 568703002936 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 568703002937 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 568703002938 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 568703002939 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 568703002940 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 568703002941 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 568703002942 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 568703002943 Phage protein; Region: DUF3647; pfam12363 568703002944 Phage-related protein [Function unknown]; Region: COG5412 568703002945 Phage tail protein; Region: Sipho_tail; pfam05709 568703002946 Phage tail protein; Region: Sipho_tail; cl17486 568703002947 Phage tail protein; Region: Sipho_tail; cl17486 568703002948 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703002949 Bacteriophage holin; Region: Phage_holin_1; pfam04531 568703002950 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703002951 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002952 active site 568703002953 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703002954 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703002955 Uncharacterized conserved protein [Function unknown]; Region: COG1359 568703002956 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 568703002957 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 568703002958 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703002959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703002962 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703002963 nucleoside/Zn binding site; other site 568703002964 dimer interface [polypeptide binding]; other site 568703002965 catalytic motif [active] 568703002966 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 568703002967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703002968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002972 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703002973 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 568703002974 catalytic core [active] 568703002975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703002979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002980 Walker A/P-loop; other site 568703002981 ATP binding site [chemical binding]; other site 568703002982 Q-loop/lid; other site 568703002983 ABC transporter signature motif; other site 568703002984 Walker B; other site 568703002985 D-loop; other site 568703002986 H-loop/switch region; other site 568703002987 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703002989 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 568703002990 Walker A/P-loop; other site 568703002991 ATP binding site [chemical binding]; other site 568703002992 Q-loop/lid; other site 568703002993 ABC transporter signature motif; other site 568703002994 Walker B; other site 568703002995 D-loop; other site 568703002996 H-loop/switch region; other site 568703002997 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 568703002998 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703002999 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 568703003000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703003001 active site 568703003002 metal binding site [ion binding]; metal-binding site 568703003003 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703003004 active site 568703003005 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703003006 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703003007 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 568703003008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703003009 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 568703003010 thymidine kinase; Provisional; Region: PRK04296 568703003011 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568703003012 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568703003013 RF-1 domain; Region: RF-1; pfam00472 568703003014 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 568703003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703003016 S-adenosylmethionine binding site [chemical binding]; other site 568703003017 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 568703003018 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 568703003019 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568703003020 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568703003021 dimer interface [polypeptide binding]; other site 568703003022 active site 568703003023 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568703003024 folate binding site [chemical binding]; other site 568703003025 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703003026 active site 568703003027 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568703003028 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568703003029 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 568703003030 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568703003031 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 568703003032 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568703003033 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568703003034 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568703003035 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568703003036 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568703003037 beta subunit interaction interface [polypeptide binding]; other site 568703003038 Walker A motif; other site 568703003039 ATP binding site [chemical binding]; other site 568703003040 Walker B motif; other site 568703003041 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703003042 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568703003043 core domain interface [polypeptide binding]; other site 568703003044 delta subunit interface [polypeptide binding]; other site 568703003045 epsilon subunit interface [polypeptide binding]; other site 568703003046 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568703003047 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568703003048 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568703003049 alpha subunit interaction interface [polypeptide binding]; other site 568703003050 Walker A motif; other site 568703003051 ATP binding site [chemical binding]; other site 568703003052 Walker B motif; other site 568703003053 inhibitor binding site; inhibition site 568703003054 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703003055 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568703003056 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568703003057 gamma subunit interface [polypeptide binding]; other site 568703003058 epsilon subunit interface [polypeptide binding]; other site 568703003059 LBP interface [polypeptide binding]; other site 568703003060 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 568703003061 rod shape-determining protein MreB; Provisional; Region: PRK13930 568703003062 MreB and similar proteins; Region: MreB_like; cd10225 568703003063 nucleotide binding site [chemical binding]; other site 568703003064 Mg binding site [ion binding]; other site 568703003065 putative protofilament interaction site [polypeptide binding]; other site 568703003066 RodZ interaction site [polypeptide binding]; other site 568703003067 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 568703003068 Haemolytic domain; Region: Haemolytic; cl00506 568703003069 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 568703003070 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 568703003071 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 568703003072 lipoyl attachment site [posttranslational modification]; other site 568703003073 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703003074 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703003075 metal binding site [ion binding]; metal-binding site 568703003076 dimer interface [polypeptide binding]; other site 568703003077 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703003078 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568703003079 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703003080 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 568703003081 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568703003082 Walker A/P-loop; other site 568703003083 ATP binding site [chemical binding]; other site 568703003084 Q-loop/lid; other site 568703003085 ABC transporter signature motif; other site 568703003086 Walker B; other site 568703003087 D-loop; other site 568703003088 H-loop/switch region; other site 568703003089 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 568703003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003091 dimer interface [polypeptide binding]; other site 568703003092 conserved gate region; other site 568703003093 ABC-ATPase subunit interface; other site 568703003094 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 568703003095 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 568703003096 Walker A/P-loop; other site 568703003097 ATP binding site [chemical binding]; other site 568703003098 Q-loop/lid; other site 568703003099 ABC transporter signature motif; other site 568703003100 Walker B; other site 568703003101 D-loop; other site 568703003102 H-loop/switch region; other site 568703003103 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 568703003104 FeS assembly protein SufD; Region: sufD; TIGR01981 568703003105 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568703003106 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568703003107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003108 catalytic residue [active] 568703003109 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 568703003110 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568703003111 trimerization site [polypeptide binding]; other site 568703003112 active site 568703003113 FeS assembly protein SufB; Region: sufB; TIGR01980 568703003114 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 568703003115 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 568703003116 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703003117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703003118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703003119 non-specific DNA binding site [nucleotide binding]; other site 568703003120 salt bridge; other site 568703003121 sequence-specific DNA binding site [nucleotide binding]; other site 568703003122 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703003123 Ligand Binding Site [chemical binding]; other site 568703003124 recombination factor protein RarA; Reviewed; Region: PRK13342 568703003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003126 Walker A motif; other site 568703003127 ATP binding site [chemical binding]; other site 568703003128 Walker B motif; other site 568703003129 arginine finger; other site 568703003130 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703003131 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 568703003132 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 568703003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 568703003134 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 568703003135 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 568703003136 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568703003137 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 568703003138 putative L-serine binding site [chemical binding]; other site 568703003139 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 568703003140 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 568703003141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703003142 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 568703003143 catalytic core [active] 568703003144 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703003145 methionine sulfoxide reductase A; Provisional; Region: PRK14054 568703003146 short chain dehydrogenase; Provisional; Region: PRK06197 568703003147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003148 NAD(P) binding site [chemical binding]; other site 568703003149 active site 568703003150 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 568703003151 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 568703003152 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 568703003153 active site 568703003154 hypothetical protein; Provisional; Region: PRK07329 568703003155 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 568703003156 active site 568703003157 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703003158 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703003159 peptide binding site [polypeptide binding]; other site 568703003160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703003161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703003162 dimer interface [polypeptide binding]; other site 568703003163 phosphorylation site [posttranslational modification] 568703003164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003165 ATP binding site [chemical binding]; other site 568703003166 Mg2+ binding site [ion binding]; other site 568703003167 G-X-G motif; other site 568703003168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003170 active site 568703003171 phosphorylation site [posttranslational modification] 568703003172 intermolecular recognition site; other site 568703003173 dimerization interface [polypeptide binding]; other site 568703003174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703003175 DNA binding site [nucleotide binding] 568703003176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703003177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003178 Walker A/P-loop; other site 568703003179 ATP binding site [chemical binding]; other site 568703003180 Q-loop/lid; other site 568703003181 ABC transporter signature motif; other site 568703003182 Walker B; other site 568703003183 D-loop; other site 568703003184 H-loop/switch region; other site 568703003185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703003187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003188 dimerization interface [polypeptide binding]; other site 568703003189 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568703003190 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 568703003191 SAP domain; Region: SAP; cl02640 568703003192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003193 Coenzyme A binding pocket [chemical binding]; other site 568703003194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003195 Coenzyme A binding pocket [chemical binding]; other site 568703003196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003197 Coenzyme A binding pocket [chemical binding]; other site 568703003198 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703003199 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703003200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703003201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003202 active site 568703003203 phosphorylation site [posttranslational modification] 568703003204 intermolecular recognition site; other site 568703003205 dimerization interface [polypeptide binding]; other site 568703003206 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703003207 DNA binding residues [nucleotide binding] 568703003208 dimerization interface [polypeptide binding]; other site 568703003209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 568703003210 Histidine kinase; Region: HisKA_3; pfam07730 568703003211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003212 ATP binding site [chemical binding]; other site 568703003213 Mg2+ binding site [ion binding]; other site 568703003214 G-X-G motif; other site 568703003215 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568703003216 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703003217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703003218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703003219 Walker A/P-loop; other site 568703003220 ATP binding site [chemical binding]; other site 568703003221 Q-loop/lid; other site 568703003222 ABC transporter signature motif; other site 568703003223 Walker B; other site 568703003224 D-loop; other site 568703003225 H-loop/switch region; other site 568703003226 TIGR02680 family protein; Region: TIGR02680 568703003227 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703003228 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 568703003229 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 568703003230 Transposase domain (DUF772); Region: DUF772; pfam05598 568703003231 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703003232 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568703003233 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568703003234 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 568703003235 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 568703003236 RNA binding site [nucleotide binding]; other site 568703003237 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568703003238 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703003239 catalytic triad [active] 568703003240 amino acid transporter; Region: 2A0306; TIGR00909 568703003241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703003242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703003243 non-specific DNA binding site [nucleotide binding]; other site 568703003244 salt bridge; other site 568703003245 sequence-specific DNA binding site [nucleotide binding]; other site 568703003246 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 568703003247 G1 box; other site 568703003248 GTP/Mg2+ binding site [chemical binding]; other site 568703003249 G2 box; other site 568703003250 Switch I region; other site 568703003251 G3 box; other site 568703003252 Switch II region; other site 568703003253 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 568703003254 AAA domain; Region: AAA_12; pfam13087 568703003255 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 568703003256 PLD-like domain; Region: PLDc_2; pfam13091 568703003257 putative active site [active] 568703003258 catalytic site [active] 568703003259 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568703003260 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568703003261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003262 RNA binding surface [nucleotide binding]; other site 568703003263 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 568703003264 GAF domain; Region: GAF_2; pfam13185 568703003265 septation ring formation regulator EzrA; Provisional; Region: PRK04778 568703003266 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 568703003267 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568703003268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003269 catalytic residue [active] 568703003270 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 568703003271 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 568703003272 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 568703003273 Ligand Binding Site [chemical binding]; other site 568703003274 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703003275 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703003276 CoA binding domain; Region: CoA_binding; pfam02629 568703003277 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568703003278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003279 active site 568703003280 HIGH motif; other site 568703003281 nucleotide binding site [chemical binding]; other site 568703003282 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703003283 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568703003284 active site 568703003285 KMSKS motif; other site 568703003286 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568703003287 tRNA binding surface [nucleotide binding]; other site 568703003288 anticodon binding site; other site 568703003289 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568703003290 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 568703003291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003292 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 568703003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703003294 motif II; other site 568703003295 hypothetical protein; Reviewed; Region: PRK00024 568703003296 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568703003297 MPN+ (JAMM) motif; other site 568703003298 Zinc-binding site [ion binding]; other site 568703003299 rod shape-determining protein MreB; Provisional; Region: PRK13927 568703003300 MreB and similar proteins; Region: MreB_like; cd10225 568703003301 nucleotide binding site [chemical binding]; other site 568703003302 Mg binding site [ion binding]; other site 568703003303 putative protofilament interaction site [polypeptide binding]; other site 568703003304 RodZ interaction site [polypeptide binding]; other site 568703003305 rod shape-determining protein MreC; Provisional; Region: PRK13922 568703003306 Protein of unknown function (DUF904); Region: DUF904; pfam06005 568703003307 rod shape-determining protein MreC; Region: MreC; pfam04085 568703003308 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 568703003309 septum formation inhibitor; Reviewed; Region: minC; PRK00513 568703003310 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568703003311 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 568703003312 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568703003313 Switch I; other site 568703003314 Switch II; other site 568703003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003316 dimer interface [polypeptide binding]; other site 568703003317 conserved gate region; other site 568703003318 putative PBP binding loops; other site 568703003319 ABC-ATPase subunit interface; other site 568703003320 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003322 Walker A/P-loop; other site 568703003323 ATP binding site [chemical binding]; other site 568703003324 Q-loop/lid; other site 568703003325 ABC transporter signature motif; other site 568703003326 Walker B; other site 568703003327 D-loop; other site 568703003328 H-loop/switch region; other site 568703003329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703003330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703003331 substrate binding pocket [chemical binding]; other site 568703003332 membrane-bound complex binding site; other site 568703003333 hinge residues; other site 568703003334 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568703003335 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568703003336 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703003337 putative active site [active] 568703003338 catalytic site [active] 568703003339 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703003340 putative active site [active] 568703003341 catalytic site [active] 568703003342 cell division protein MraZ; Reviewed; Region: PRK00326 568703003343 MraZ protein; Region: MraZ; pfam02381 568703003344 MraZ protein; Region: MraZ; pfam02381 568703003345 MraW methylase family; Region: Methyltransf_5; pfam01795 568703003346 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 568703003347 Cell division protein FtsL; Region: FtsL; cl11433 568703003348 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703003349 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703003350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703003351 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 568703003352 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 568703003353 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568703003354 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568703003355 Mg++ binding site [ion binding]; other site 568703003356 putative catalytic motif [active] 568703003357 putative substrate binding site [chemical binding]; other site 568703003358 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 568703003359 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 568703003360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703003361 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003362 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568703003363 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568703003364 active site 568703003365 homodimer interface [polypeptide binding]; other site 568703003366 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568703003367 Cell division protein FtsQ; Region: FtsQ; pfam03799 568703003368 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 568703003369 Cell division protein FtsA; Region: FtsA; smart00842 568703003370 Cell division protein FtsA; Region: FtsA; pfam14450 568703003371 cell division protein FtsZ; Validated; Region: PRK09330 568703003372 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568703003373 nucleotide binding site [chemical binding]; other site 568703003374 SulA interaction site; other site 568703003375 Protein of unknown function (DUF552); Region: DUF552; pfam04472 568703003376 YGGT family; Region: YGGT; pfam02325 568703003377 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 568703003378 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003379 RNA binding surface [nucleotide binding]; other site 568703003380 DivIVA protein; Region: DivIVA; pfam05103 568703003381 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703003382 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 568703003383 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568703003384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003385 active site 568703003386 HIGH motif; other site 568703003387 nucleotide binding site [chemical binding]; other site 568703003388 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703003389 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568703003390 active site 568703003391 KMSKS motif; other site 568703003392 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568703003393 tRNA binding surface [nucleotide binding]; other site 568703003394 anticodon binding site; other site 568703003395 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703003396 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703003397 DNA-binding site [nucleotide binding]; DNA binding site 568703003398 RNA-binding motif; other site 568703003399 PBP superfamily domain; Region: PBP_like_2; cl17296 568703003400 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568703003401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703003403 putative substrate translocation pore; other site 568703003404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003405 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 568703003406 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 568703003407 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568703003408 dimer interface [polypeptide binding]; other site 568703003409 ADP-ribose binding site [chemical binding]; other site 568703003410 active site 568703003411 nudix motif; other site 568703003412 metal binding site [ion binding]; metal-binding site 568703003413 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 568703003414 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 568703003415 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568703003416 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 568703003417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003418 catalytic residue [active] 568703003419 Putative amino acid metabolism; Region: DUF1831; pfam08866 568703003420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003421 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 568703003422 Walker A/P-loop; other site 568703003423 ATP binding site [chemical binding]; other site 568703003424 Q-loop/lid; other site 568703003425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003426 ABC transporter signature motif; other site 568703003427 Walker B; other site 568703003428 D-loop; other site 568703003429 H-loop/switch region; other site 568703003430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003431 Walker A/P-loop; other site 568703003432 ATP binding site [chemical binding]; other site 568703003433 Q-loop/lid; other site 568703003434 ABC transporter signature motif; other site 568703003435 Walker B; other site 568703003436 D-loop; other site 568703003437 H-loop/switch region; other site 568703003438 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 568703003439 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568703003440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703003441 catalytic core [active] 568703003442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003443 binding surface 568703003444 TPR motif; other site 568703003445 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 568703003446 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 568703003447 AAA domain; Region: AAA_30; pfam13604 568703003448 Family description; Region: UvrD_C_2; pfam13538 568703003449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 568703003450 Sterol carrier protein domain; Region: SCP2_2; pfam13530 568703003451 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703003452 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703003453 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 568703003455 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003456 hypothetical protein; Provisional; Region: PRK13667 568703003457 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568703003458 active site 568703003459 catalytic residues [active] 568703003460 metal binding site [ion binding]; metal-binding site 568703003461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703003462 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 568703003463 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568703003464 TPP-binding site [chemical binding]; other site 568703003465 tetramer interface [polypeptide binding]; other site 568703003466 heterodimer interface [polypeptide binding]; other site 568703003467 phosphorylation loop region [posttranslational modification] 568703003468 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568703003469 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568703003470 alpha subunit interface [polypeptide binding]; other site 568703003471 TPP binding site [chemical binding]; other site 568703003472 heterodimer interface [polypeptide binding]; other site 568703003473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703003474 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568703003475 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568703003476 E3 interaction surface; other site 568703003477 lipoyl attachment site [posttranslational modification]; other site 568703003478 e3 binding domain; Region: E3_binding; pfam02817 568703003479 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568703003480 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 568703003481 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 568703003482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703003483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703003484 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 568703003485 substrate binding site [chemical binding]; other site 568703003486 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 568703003487 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568703003488 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 568703003489 active site 568703003490 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 568703003491 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568703003492 G1 box; other site 568703003493 putative GEF interaction site [polypeptide binding]; other site 568703003494 GTP/Mg2+ binding site [chemical binding]; other site 568703003495 Switch I region; other site 568703003496 G2 box; other site 568703003497 G3 box; other site 568703003498 Switch II region; other site 568703003499 G4 box; other site 568703003500 G5 box; other site 568703003501 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568703003502 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568703003503 cell division protein FtsW; Region: ftsW; TIGR02614 568703003504 pyruvate carboxylase; Reviewed; Region: PRK12999 568703003505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703003506 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568703003507 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568703003508 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703003509 active site 568703003510 catalytic residues [active] 568703003511 metal binding site [ion binding]; metal-binding site 568703003512 homodimer binding site [polypeptide binding]; other site 568703003513 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703003514 carboxyltransferase (CT) interaction site; other site 568703003515 biotinylation site [posttranslational modification]; other site 568703003516 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 568703003517 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 568703003518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703003519 S-adenosylmethionine binding site [chemical binding]; other site 568703003520 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568703003521 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568703003522 active site 568703003523 (T/H)XGH motif; other site 568703003524 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 568703003525 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 568703003526 protein binding site [polypeptide binding]; other site 568703003527 SLBB domain; Region: SLBB; pfam10531 568703003528 comEA protein; Region: comE; TIGR01259 568703003529 Helix-hairpin-helix motif; Region: HHH; pfam00633 568703003530 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 568703003531 Competence protein; Region: Competence; pfam03772 568703003532 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 568703003533 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 568703003534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703003535 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568703003536 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568703003537 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 568703003538 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568703003539 16S/18S rRNA binding site [nucleotide binding]; other site 568703003540 S13e-L30e interaction site [polypeptide binding]; other site 568703003541 25S rRNA binding site [nucleotide binding]; other site 568703003542 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003543 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703003544 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003545 elongation factor Tu; Reviewed; Region: PRK00049 568703003546 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568703003547 G1 box; other site 568703003548 GEF interaction site [polypeptide binding]; other site 568703003549 GTP/Mg2+ binding site [chemical binding]; other site 568703003550 Switch I region; other site 568703003551 G2 box; other site 568703003552 G3 box; other site 568703003553 Switch II region; other site 568703003554 G4 box; other site 568703003555 G5 box; other site 568703003556 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568703003557 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568703003558 Antibiotic Binding Site [chemical binding]; other site 568703003559 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003560 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003561 NAD-dependent deacetylase; Provisional; Region: PRK00481 568703003562 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703003563 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568703003564 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703003565 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703003566 DNA binding residues [nucleotide binding] 568703003567 putative dimer interface [polypeptide binding]; other site 568703003568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703003569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703003570 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568703003571 Walker A/P-loop; other site 568703003572 ATP binding site [chemical binding]; other site 568703003573 Q-loop/lid; other site 568703003574 ABC transporter signature motif; other site 568703003575 Walker B; other site 568703003576 D-loop; other site 568703003577 H-loop/switch region; other site 568703003578 trigger factor; Provisional; Region: tig; PRK01490 568703003579 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568703003580 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568703003581 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568703003582 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568703003583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003584 Walker A motif; other site 568703003585 ATP binding site [chemical binding]; other site 568703003586 Walker B motif; other site 568703003587 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003588 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568703003589 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 568703003590 G1 box; other site 568703003591 GTP/Mg2+ binding site [chemical binding]; other site 568703003592 Switch I region; other site 568703003593 G2 box; other site 568703003594 G3 box; other site 568703003595 Switch II region; other site 568703003596 G4 box; other site 568703003597 G5 box; other site 568703003598 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 568703003599 putative metal binding site [ion binding]; other site 568703003600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703003601 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703003602 substrate binding pocket [chemical binding]; other site 568703003603 membrane-bound complex binding site; other site 568703003604 hinge residues; other site 568703003605 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703003606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003607 dimer interface [polypeptide binding]; other site 568703003608 conserved gate region; other site 568703003609 putative PBP binding loops; other site 568703003610 ABC-ATPase subunit interface; other site 568703003611 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703003612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703003613 Walker A/P-loop; other site 568703003614 ATP binding site [chemical binding]; other site 568703003615 Q-loop/lid; other site 568703003616 ABC transporter signature motif; other site 568703003617 Walker B; other site 568703003618 D-loop; other site 568703003619 H-loop/switch region; other site 568703003620 Pleckstrin homology-like domain; Region: PH-like; cl17171 568703003621 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568703003622 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568703003623 GIY-YIG motif/motif A; other site 568703003624 active site 568703003625 catalytic site [active] 568703003626 putative DNA binding site [nucleotide binding]; other site 568703003627 metal binding site [ion binding]; metal-binding site 568703003628 UvrB/uvrC motif; Region: UVR; pfam02151 568703003629 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568703003630 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 568703003631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703003632 active site 568703003633 phosphorylation site [posttranslational modification] 568703003634 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703003635 active site 568703003636 P-loop; other site 568703003637 phosphorylation site [posttranslational modification] 568703003638 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703003639 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703003640 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703003641 putative substrate binding site [chemical binding]; other site 568703003642 putative ATP binding site [chemical binding]; other site 568703003643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703003644 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568703003645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703003646 GTPase CgtA; Reviewed; Region: obgE; PRK12297 568703003647 GTP1/OBG; Region: GTP1_OBG; pfam01018 568703003648 Obg GTPase; Region: Obg; cd01898 568703003649 G1 box; other site 568703003650 GTP/Mg2+ binding site [chemical binding]; other site 568703003651 Switch I region; other site 568703003652 G2 box; other site 568703003653 G3 box; other site 568703003654 Switch II region; other site 568703003655 G4 box; other site 568703003656 G5 box; other site 568703003657 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 568703003658 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703003659 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703003660 catalytic triad [active] 568703003661 catalytic triad [active] 568703003662 oxyanion hole [active] 568703003663 ribonuclease Z; Region: RNase_Z; TIGR02651 568703003664 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 568703003665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003666 NAD(P) binding site [chemical binding]; other site 568703003667 active site 568703003668 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 568703003669 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 568703003670 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003671 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003673 Walker A motif; other site 568703003674 ATP binding site [chemical binding]; other site 568703003675 Walker B motif; other site 568703003676 arginine finger; other site 568703003677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003678 Walker A motif; other site 568703003679 ATP binding site [chemical binding]; other site 568703003680 Walker B motif; other site 568703003681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003682 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 568703003683 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 568703003684 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 568703003685 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 568703003686 active site 568703003687 metal binding site [ion binding]; metal-binding site 568703003688 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703003689 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 568703003690 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 568703003691 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 568703003692 active site 568703003693 PHP Thumb interface [polypeptide binding]; other site 568703003694 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568703003695 generic binding surface I; other site 568703003696 generic binding surface II; other site 568703003697 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 568703003698 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 568703003699 active site 568703003700 ADP/pyrophosphate binding site [chemical binding]; other site 568703003701 dimerization interface [polypeptide binding]; other site 568703003702 allosteric effector site; other site 568703003703 fructose-1,6-bisphosphate binding site; other site 568703003704 pyruvate kinase; Provisional; Region: PRK06354 568703003705 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 568703003706 domain interfaces; other site 568703003707 active site 568703003708 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 568703003709 Protein of unknown function (DUF441); Region: DUF441; pfam04284 568703003710 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 568703003711 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568703003712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 568703003713 active site 568703003714 Int/Topo IB signature motif; other site 568703003715 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 568703003716 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 568703003717 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703003718 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003719 RNA binding surface [nucleotide binding]; other site 568703003720 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 568703003721 active site 568703003722 Predicted membrane protein [Function unknown]; Region: COG3601 568703003723 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703003724 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 568703003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 568703003726 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703003727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703003728 ATP binding site [chemical binding]; other site 568703003729 putative Mg++ binding site [ion binding]; other site 568703003730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703003731 nucleotide binding region [chemical binding]; other site 568703003732 ATP-binding site [chemical binding]; other site 568703003733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703003734 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568703003735 cytidylate kinase; Provisional; Region: cmk; PRK00023 568703003736 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568703003737 CMP-binding site; other site 568703003738 The sites determining sugar specificity; other site 568703003739 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 568703003740 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568703003741 RNA binding site [nucleotide binding]; other site 568703003742 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568703003743 RNA binding site [nucleotide binding]; other site 568703003744 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568703003745 RNA binding site [nucleotide binding]; other site 568703003746 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 568703003747 RNA binding site [nucleotide binding]; other site 568703003748 GTP-binding protein Der; Reviewed; Region: PRK00093 568703003749 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568703003750 G1 box; other site 568703003751 GTP/Mg2+ binding site [chemical binding]; other site 568703003752 Switch I region; other site 568703003753 G2 box; other site 568703003754 Switch II region; other site 568703003755 G3 box; other site 568703003756 G4 box; other site 568703003757 G5 box; other site 568703003758 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568703003759 G1 box; other site 568703003760 GTP/Mg2+ binding site [chemical binding]; other site 568703003761 Switch I region; other site 568703003762 G2 box; other site 568703003763 G3 box; other site 568703003764 Switch II region; other site 568703003765 G4 box; other site 568703003766 G5 box; other site 568703003767 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568703003768 IHF dimer interface [polypeptide binding]; other site 568703003769 IHF - DNA interface [nucleotide binding]; other site 568703003770 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 568703003771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003772 TPR motif; other site 568703003773 binding surface 568703003774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003775 binding surface 568703003776 TPR motif; other site 568703003777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003778 binding surface 568703003779 TPR motif; other site 568703003780 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703003781 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003782 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003783 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703003784 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 568703003785 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568703003786 active site 568703003787 NTP binding site [chemical binding]; other site 568703003788 metal binding triad [ion binding]; metal-binding site 568703003789 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568703003790 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 568703003791 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703003792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003793 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003794 ABC transporter; Region: ABC_tran_2; pfam12848 568703003795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003796 thymidylate synthase; Region: thym_sym; TIGR03284 568703003797 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568703003798 dimerization interface [polypeptide binding]; other site 568703003799 active site 568703003800 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568703003801 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568703003802 folate binding site [chemical binding]; other site 568703003803 NADP+ binding site [chemical binding]; other site 568703003804 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 568703003805 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 568703003806 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703003807 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703003808 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 568703003809 active site 568703003810 catalytic triad [active] 568703003811 oxyanion hole [active] 568703003812 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 568703003813 methionine sulfoxide reductase A; Provisional; Region: PRK14054 568703003814 hypothetical protein; Provisional; Region: PRK13672 568703003815 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 568703003816 C-terminal peptidase (prc); Region: prc; TIGR00225 568703003817 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568703003818 protein binding site [polypeptide binding]; other site 568703003819 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568703003820 Catalytic dyad [active] 568703003821 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568703003822 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 568703003823 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 568703003824 GTP/Mg2+ binding site [chemical binding]; other site 568703003825 G4 box; other site 568703003826 G5 box; other site 568703003827 G1 box; other site 568703003828 Switch I region; other site 568703003829 G2 box; other site 568703003830 G3 box; other site 568703003831 Switch II region; other site 568703003832 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568703003833 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703003834 active site 568703003835 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 568703003836 DNA protecting protein DprA; Region: dprA; TIGR00732 568703003837 DNA topoisomerase I; Validated; Region: PRK05582 568703003838 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 568703003839 active site 568703003840 interdomain interaction site; other site 568703003841 putative metal-binding site [ion binding]; other site 568703003842 nucleotide binding site [chemical binding]; other site 568703003843 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568703003844 domain I; other site 568703003845 DNA binding groove [nucleotide binding] 568703003846 phosphate binding site [ion binding]; other site 568703003847 domain II; other site 568703003848 domain III; other site 568703003849 nucleotide binding site [chemical binding]; other site 568703003850 catalytic site [active] 568703003851 domain IV; other site 568703003852 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568703003853 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568703003854 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 568703003855 Glucose inhibited division protein A; Region: GIDA; pfam01134 568703003856 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568703003857 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568703003858 active site 568703003859 Int/Topo IB signature motif; other site 568703003860 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568703003861 active site 568703003862 HslU subunit interaction site [polypeptide binding]; other site 568703003863 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cl00787 568703003864 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568703003865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003866 Walker A motif; other site 568703003867 ATP binding site [chemical binding]; other site 568703003868 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 568703003869 Walker B motif; other site 568703003870 arginine finger; other site 568703003871 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003872 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703003873 active site 568703003874 catalytic residues [active] 568703003875 membrane protein; Provisional; Region: PRK14392 568703003876 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 568703003877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003878 Mg2+ binding site [ion binding]; other site 568703003879 G-X-G motif; other site 568703003880 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568703003881 anchoring element; other site 568703003882 dimer interface [polypeptide binding]; other site 568703003883 ATP binding site [chemical binding]; other site 568703003884 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568703003885 active site 568703003886 putative metal-binding site [ion binding]; other site 568703003887 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703003888 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568703003889 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568703003890 CAP-like domain; other site 568703003891 active site 568703003892 primary dimer interface [polypeptide binding]; other site 568703003893 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703003894 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 568703003895 Pyruvate formate lyase 1; Region: PFL1; cd01678 568703003896 coenzyme A binding site [chemical binding]; other site 568703003897 active site 568703003898 catalytic residues [active] 568703003899 glycine loop; other site 568703003900 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 568703003901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568703003902 FeS/SAM binding site; other site 568703003903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703003905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003906 dimerization interface [polypeptide binding]; other site 568703003907 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 568703003908 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703003909 DHHA2 domain; Region: DHHA2; pfam02833 568703003910 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 568703003911 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 568703003912 active site 568703003913 catalytic residues [active] 568703003914 DNA binding site [nucleotide binding] 568703003915 Int/Topo IB signature motif; other site 568703003916 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003917 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703003918 Walker A/P-loop; other site 568703003919 ATP binding site [chemical binding]; other site 568703003920 Q-loop/lid; other site 568703003921 ABC transporter signature motif; other site 568703003922 Walker B; other site 568703003923 D-loop; other site 568703003924 H-loop/switch region; other site 568703003925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703003926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003927 ATP binding site [chemical binding]; other site 568703003928 Mg2+ binding site [ion binding]; other site 568703003929 G-X-G motif; other site 568703003930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003932 active site 568703003933 phosphorylation site [posttranslational modification] 568703003934 intermolecular recognition site; other site 568703003935 dimerization interface [polypeptide binding]; other site 568703003936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703003937 DNA binding site [nucleotide binding] 568703003938 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703003939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003940 putative substrate translocation pore; other site 568703003941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703003943 Coenzyme A binding pocket [chemical binding]; other site 568703003944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003945 Coenzyme A binding pocket [chemical binding]; other site 568703003946 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703003947 dimer interface [polypeptide binding]; other site 568703003948 FMN binding site [chemical binding]; other site 568703003949 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568703003950 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568703003951 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 568703003952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003954 homodimer interface [polypeptide binding]; other site 568703003955 catalytic residue [active] 568703003956 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 568703003957 metal binding site [ion binding]; metal-binding site 568703003958 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 568703003959 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 568703003960 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568703003961 substrate binding site [chemical binding]; other site 568703003962 glutamase interaction surface [polypeptide binding]; other site 568703003963 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 568703003964 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568703003965 catalytic residues [active] 568703003966 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 568703003967 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568703003968 putative active site [active] 568703003969 oxyanion strand; other site 568703003970 catalytic triad [active] 568703003971 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568703003972 4-fold oligomerization interface [polypeptide binding]; other site 568703003973 putative active site pocket [active] 568703003974 metal binding residues [ion binding]; metal-binding site 568703003975 3-fold/trimer interface [polypeptide binding]; other site 568703003976 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 568703003977 histidinol dehydrogenase; Region: hisD; TIGR00069 568703003978 NAD binding site [chemical binding]; other site 568703003979 dimerization interface [polypeptide binding]; other site 568703003980 product binding site; other site 568703003981 substrate binding site [chemical binding]; other site 568703003982 zinc binding site [ion binding]; other site 568703003983 catalytic residues [active] 568703003984 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 568703003985 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 568703003986 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 568703003987 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568703003988 dimer interface [polypeptide binding]; other site 568703003989 motif 1; other site 568703003990 active site 568703003991 motif 2; other site 568703003992 motif 3; other site 568703003993 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 568703003994 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003996 homodimer interface [polypeptide binding]; other site 568703003997 catalytic residue [active] 568703003998 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568703003999 dimer interface [polypeptide binding]; other site 568703004000 ADP-ribose binding site [chemical binding]; other site 568703004001 active site 568703004002 nudix motif; other site 568703004003 metal binding site [ion binding]; metal-binding site 568703004004 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703004005 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703004006 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 568703004007 Domain of unknown function (DUF814); Region: DUF814; pfam05670 568703004008 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 568703004009 metal binding site [ion binding]; metal-binding site 568703004010 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703004011 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 568703004012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004013 active site 568703004014 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568703004015 active site 568703004016 dimer interface [polypeptide binding]; other site 568703004017 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 568703004018 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 568703004019 heterodimer interface [polypeptide binding]; other site 568703004020 active site 568703004021 FMN binding site [chemical binding]; other site 568703004022 homodimer interface [polypeptide binding]; other site 568703004023 substrate binding site [chemical binding]; other site 568703004024 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568703004025 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703004026 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568703004027 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568703004028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703004029 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703004030 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568703004031 IMP binding site; other site 568703004032 dimer interface [polypeptide binding]; other site 568703004033 interdomain contacts; other site 568703004034 partial ornithine binding site; other site 568703004035 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568703004036 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568703004037 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568703004038 catalytic site [active] 568703004039 subunit interface [polypeptide binding]; other site 568703004040 dihydroorotase; Validated; Region: pyrC; PRK09357 568703004041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703004042 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 568703004043 active site 568703004044 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 568703004045 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568703004046 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568703004047 uracil transporter; Provisional; Region: PRK10720 568703004048 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 568703004049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004050 active site 568703004051 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703004052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703004053 RNA binding surface [nucleotide binding]; other site 568703004054 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703004055 active site 568703004056 lipoprotein signal peptidase; Provisional; Region: PRK14797 568703004057 lipoprotein signal peptidase; Provisional; Region: PRK14787 568703004058 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 568703004059 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 568703004060 Potassium binding sites [ion binding]; other site 568703004061 Cesium cation binding sites [ion binding]; other site 568703004062 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 568703004063 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703004064 active site 568703004065 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 568703004066 dimer interface [polypeptide binding]; other site 568703004067 FMN binding site [chemical binding]; other site 568703004068 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568703004069 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 568703004070 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703004071 putative active site [active] 568703004072 catalytic site [active] 568703004073 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703004074 putative active site [active] 568703004075 catalytic site [active] 568703004076 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703004077 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 568703004078 catalytic residues [active] 568703004079 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 568703004080 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 568703004081 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568703004082 active site 568703004083 dimer interface [polypeptide binding]; other site 568703004084 catalytic residues [active] 568703004085 effector binding site; other site 568703004086 R2 peptide binding site; other site 568703004087 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 568703004088 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568703004089 dimer interface [polypeptide binding]; other site 568703004090 putative radical transfer pathway; other site 568703004091 diiron center [ion binding]; other site 568703004092 tyrosyl radical; other site 568703004093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703004094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703004095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703004096 dimerization interface [polypeptide binding]; other site 568703004097 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703004098 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703004099 active site 568703004100 Zn binding site [ion binding]; other site 568703004101 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 568703004102 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568703004103 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 568703004104 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 568703004105 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568703004106 putative ligand binding site [chemical binding]; other site 568703004107 NAD binding site [chemical binding]; other site 568703004108 catalytic site [active] 568703004109 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 568703004110 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 568703004111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568703004112 cell division protein GpsB; Provisional; Region: PRK14127 568703004113 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703004114 hypothetical protein; Provisional; Region: PRK13660 568703004115 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 568703004116 Transglycosylase; Region: Transgly; pfam00912 568703004117 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703004118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703004119 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 568703004120 catalytic motif [active] 568703004121 Zn binding site [ion binding]; other site 568703004122 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 568703004123 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703004124 minor groove reading motif; other site 568703004125 helix-hairpin-helix signature motif; other site 568703004126 substrate binding pocket [chemical binding]; other site 568703004127 active site 568703004128 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 568703004129 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 568703004130 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 568703004131 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 568703004132 putative dimer interface [polypeptide binding]; other site 568703004133 putative anticodon binding site; other site 568703004134 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 568703004135 homodimer interface [polypeptide binding]; other site 568703004136 motif 1; other site 568703004137 motif 2; other site 568703004138 active site 568703004139 motif 3; other site 568703004140 aspartate aminotransferase; Provisional; Region: PRK05764 568703004141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703004142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703004143 homodimer interface [polypeptide binding]; other site 568703004144 catalytic residue [active] 568703004145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 568703004146 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 568703004147 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703004148 active site 568703004149 catalytic site [active] 568703004150 substrate binding site [chemical binding]; other site 568703004151 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568703004152 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 568703004153 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568703004154 ATP binding site [chemical binding]; other site 568703004155 Family description; Region: UvrD_C_2; pfam13538 568703004156 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568703004157 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 568703004158 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568703004159 mevalonate kinase; Region: mevalon_kin; TIGR00549 568703004160 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703004161 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703004162 diphosphomevalonate decarboxylase; Region: PLN02407 568703004163 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 568703004164 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 568703004165 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 568703004166 homotetramer interface [polypeptide binding]; other site 568703004167 FMN binding site [chemical binding]; other site 568703004168 homodimer contacts [polypeptide binding]; other site 568703004169 putative active site [active] 568703004170 putative substrate binding site [chemical binding]; other site 568703004171 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 568703004172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004173 S-adenosylmethionine binding site [chemical binding]; other site 568703004174 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 568703004175 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 568703004176 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 568703004177 active site 1 [active] 568703004178 dimer interface [polypeptide binding]; other site 568703004179 hexamer interface [polypeptide binding]; other site 568703004180 active site 2 [active] 568703004181 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004182 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004184 Walker A/P-loop; other site 568703004185 ATP binding site [chemical binding]; other site 568703004186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004188 Walker A/P-loop; other site 568703004189 ATP binding site [chemical binding]; other site 568703004190 Q-loop/lid; other site 568703004191 ABC transporter signature motif; other site 568703004192 Walker B; other site 568703004193 D-loop; other site 568703004194 H-loop/switch region; other site 568703004195 Uncharacterized conserved protein [Function unknown]; Region: COG0327 568703004196 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 568703004197 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 568703004198 Family of unknown function (DUF633); Region: DUF633; pfam04816 568703004199 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 568703004200 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568703004201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703004202 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568703004203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568703004204 DNA binding residues [nucleotide binding] 568703004205 DNA primase; Validated; Region: dnaG; PRK05667 568703004206 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568703004207 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568703004208 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568703004209 active site 568703004210 metal binding site [ion binding]; metal-binding site 568703004211 interdomain interaction site; other site 568703004212 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568703004213 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568703004214 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568703004215 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568703004216 dimer interface [polypeptide binding]; other site 568703004217 motif 1; other site 568703004218 active site 568703004219 motif 2; other site 568703004220 motif 3; other site 568703004221 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568703004222 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703004223 Int/Topo IB signature motif; other site 568703004224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703004225 salt bridge; other site 568703004226 non-specific DNA binding site [nucleotide binding]; other site 568703004227 sequence-specific DNA binding site [nucleotide binding]; other site 568703004228 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703004229 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703004230 active site 568703004231 Bacterial SH3 domain; Region: SH3_5; pfam08460 568703004232 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568703004233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703004234 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 568703004235 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703004236 Phage tail protein; Region: Sipho_tail; pfam05709 568703004237 Phage tail protein; Region: Sipho_tail; cl17486 568703004238 Phage-related tail protein [Function unknown]; Region: COG5283 568703004239 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 568703004240 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 568703004241 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568703004242 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568703004243 catalytic residue [active] 568703004244 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 568703004245 Phage major tail protein; Region: Phage_tail; pfam04630 568703004246 Protein of unknown function (DUF806); Region: DUF806; pfam05657 568703004247 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 568703004248 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 568703004249 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568703004250 Phage capsid family; Region: Phage_capsid; pfam05065 568703004251 Phage-related protein [Function unknown]; Region: COG4695 568703004252 Phage portal protein; Region: Phage_portal; pfam04860 568703004253 Phage Terminase; Region: Terminase_1; pfam03354 568703004254 Phage terminase, small subunit; Region: Terminase_4; pfam05119 568703004255 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568703004256 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568703004257 catalytic residues [active] 568703004258 catalytic nucleophile [active] 568703004259 Presynaptic Site I dimer interface [polypeptide binding]; other site 568703004260 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568703004261 Synaptic Flat tetramer interface [polypeptide binding]; other site 568703004262 Synaptic Site I dimer interface [polypeptide binding]; other site 568703004263 DNA binding site [nucleotide binding] 568703004264 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 568703004265 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 568703004266 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 568703004267 DXD motif; other site 568703004268 Transposase domain (DUF772); Region: DUF772; pfam05598 568703004269 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004270 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 568703004271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568703004272 active site 568703004273 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703004274 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703004275 dimer interface [polypeptide binding]; other site 568703004276 ssDNA binding site [nucleotide binding]; other site 568703004277 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703004278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703004279 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703004280 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 568703004281 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568703004282 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703004283 Walker A/P-loop; other site 568703004284 ATP binding site [chemical binding]; other site 568703004285 Q-loop/lid; other site 568703004286 ABC transporter signature motif; other site 568703004287 Walker B; other site 568703004288 D-loop; other site 568703004289 H-loop/switch region; other site 568703004290 Recombination protein O N terminal; Region: RecO_N; pfam11967 568703004291 DNA repair protein RecO; Region: reco; TIGR00613 568703004292 Recombination protein O C terminal; Region: RecO_C; pfam02565 568703004293 GTPase Era; Reviewed; Region: era; PRK00089 568703004294 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568703004295 G1 box; other site 568703004296 GTP/Mg2+ binding site [chemical binding]; other site 568703004297 Switch I region; other site 568703004298 G2 box; other site 568703004299 Switch II region; other site 568703004300 G3 box; other site 568703004301 G4 box; other site 568703004302 G5 box; other site 568703004303 KH domain; Region: KH_2; pfam07650 568703004304 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 568703004305 active site 568703004306 catalytic motif [active] 568703004307 Zn binding site [ion binding]; other site 568703004308 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 568703004309 metal-binding heat shock protein; Provisional; Region: PRK00016 568703004310 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568703004311 PhoH-like protein; Region: PhoH; pfam02562 568703004312 Yqey-like protein; Region: YqeY; pfam09424 568703004313 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568703004314 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 568703004315 endonuclease IV; Provisional; Region: PRK01060 568703004316 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568703004317 AP (apurinic/apyrimidinic) site pocket; other site 568703004318 DNA interaction; other site 568703004319 Metal-binding active site; metal-binding site 568703004320 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703004321 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703004322 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703004323 methionine sulfoxide reductase B; Provisional; Region: PRK00222 568703004324 SelR domain; Region: SelR; pfam01641 568703004325 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568703004326 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568703004327 dimer interface [polypeptide binding]; other site 568703004328 anticodon binding site; other site 568703004329 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568703004330 homodimer interface [polypeptide binding]; other site 568703004331 motif 1; other site 568703004332 active site 568703004333 motif 2; other site 568703004334 GAD domain; Region: GAD; pfam02938 568703004335 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568703004336 motif 3; other site 568703004337 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568703004338 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568703004339 dimer interface [polypeptide binding]; other site 568703004340 motif 1; other site 568703004341 active site 568703004342 motif 2; other site 568703004343 motif 3; other site 568703004344 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568703004345 anticodon binding site; other site 568703004346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703004347 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 568703004348 Walker A/P-loop; other site 568703004349 ATP binding site [chemical binding]; other site 568703004350 Q-loop/lid; other site 568703004351 ABC transporter signature motif; other site 568703004352 Walker B; other site 568703004353 D-loop; other site 568703004354 H-loop/switch region; other site 568703004355 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 568703004356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 568703004357 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004358 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004359 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004360 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 568703004361 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568703004362 active site 568703004363 metal binding site [ion binding]; metal-binding site 568703004364 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703004365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703004366 motif II; other site 568703004367 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 568703004368 putative active site [active] 568703004369 dimerization interface [polypeptide binding]; other site 568703004370 putative tRNAtyr binding site [nucleotide binding]; other site 568703004371 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568703004372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004373 Zn2+ binding site [ion binding]; other site 568703004374 Mg2+ binding site [ion binding]; other site 568703004375 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703004376 synthetase active site [active] 568703004377 NTP binding site [chemical binding]; other site 568703004378 metal binding site [ion binding]; metal-binding site 568703004379 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568703004380 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568703004381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 568703004382 RNA methyltransferase, RsmE family; Region: TIGR00046 568703004383 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 568703004384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004385 S-adenosylmethionine binding site [chemical binding]; other site 568703004386 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 568703004387 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 568703004388 active site 568703004389 DNA binding site [nucleotide binding] 568703004390 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703004391 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703004392 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703004393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703004394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703004395 WHG domain; Region: WHG; pfam13305 568703004396 Transposase domain (DUF772); Region: DUF772; pfam05598 568703004397 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004398 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703004399 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703004400 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703004401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703004402 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004403 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703004404 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004405 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703004406 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703004408 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703004409 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004410 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004411 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 568703004412 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004413 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703004414 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004415 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004416 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703004417 surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319 568703004418 surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319 568703004419 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 568703004420 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 568703004421 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 568703004422 putative deacylase active site [active] 568703004423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004424 active site 568703004425 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 568703004426 DHH family; Region: DHH; pfam01368 568703004427 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 568703004428 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703004429 GTP-binding protein LepA; Provisional; Region: PRK05433 568703004430 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568703004431 G1 box; other site 568703004432 putative GEF interaction site [polypeptide binding]; other site 568703004433 GTP/Mg2+ binding site [chemical binding]; other site 568703004434 Switch I region; other site 568703004435 G2 box; other site 568703004436 G3 box; other site 568703004437 Switch II region; other site 568703004438 G4 box; other site 568703004439 G5 box; other site 568703004440 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568703004441 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568703004442 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568703004443 chaperone protein DnaJ; Provisional; Region: PRK14276 568703004444 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568703004445 HSP70 interaction site [polypeptide binding]; other site 568703004446 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 568703004447 substrate binding site [polypeptide binding]; other site 568703004448 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568703004449 Zn binding sites [ion binding]; other site 568703004450 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568703004451 dimer interface [polypeptide binding]; other site 568703004452 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568703004453 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 568703004454 nucleotide binding site [chemical binding]; other site 568703004455 NEF interaction site [polypeptide binding]; other site 568703004456 SBD interface [polypeptide binding]; other site 568703004457 GrpE; Region: GrpE; pfam01025 568703004458 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568703004459 dimer interface [polypeptide binding]; other site 568703004460 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568703004461 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 568703004462 HTH domain; Region: HTH_11; pfam08279 568703004463 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 568703004464 HemN C-terminal domain; Region: HemN_C; pfam06969 568703004465 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568703004466 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568703004467 active site 568703004468 Riboflavin kinase; Region: Flavokinase; smart00904 568703004469 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 568703004470 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568703004471 RNA binding site [nucleotide binding]; other site 568703004472 active site 568703004473 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 568703004474 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568703004475 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004476 translation initiation factor IF-2; Region: IF-2; TIGR00487 568703004477 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004478 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568703004479 G1 box; other site 568703004480 putative GEF interaction site [polypeptide binding]; other site 568703004481 GTP/Mg2+ binding site [chemical binding]; other site 568703004482 Switch I region; other site 568703004483 G2 box; other site 568703004484 G3 box; other site 568703004485 Switch II region; other site 568703004486 G4 box; other site 568703004487 G5 box; other site 568703004488 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568703004489 Translation-initiation factor 2; Region: IF-2; pfam11987 568703004490 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568703004491 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 568703004492 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 568703004493 putative RNA binding cleft [nucleotide binding]; other site 568703004494 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 568703004495 NusA N-terminal domain; Region: NusA_N; pfam08529 568703004496 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568703004497 RNA binding site [nucleotide binding]; other site 568703004498 homodimer interface [polypeptide binding]; other site 568703004499 NusA-like KH domain; Region: KH_5; pfam13184 568703004500 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568703004501 G-X-X-G motif; other site 568703004502 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568703004503 Sm and related proteins; Region: Sm_like; cl00259 568703004504 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568703004505 putative oligomer interface [polypeptide binding]; other site 568703004506 putative RNA binding site [nucleotide binding]; other site 568703004507 DNA polymerase III PolC; Validated; Region: polC; PRK00448 568703004508 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 568703004509 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 568703004510 generic binding surface II; other site 568703004511 generic binding surface I; other site 568703004512 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 568703004513 active site 568703004514 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703004515 active site 568703004516 catalytic site [active] 568703004517 substrate binding site [chemical binding]; other site 568703004518 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 568703004519 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568703004520 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568703004521 dimer interface [polypeptide binding]; other site 568703004522 motif 1; other site 568703004523 active site 568703004524 motif 2; other site 568703004525 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 568703004526 putative deacylase active site [active] 568703004527 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568703004528 active site 568703004529 motif 3; other site 568703004530 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568703004531 anticodon binding site; other site 568703004532 RIP metalloprotease RseP; Region: TIGR00054 568703004533 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568703004534 active site 568703004535 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004536 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568703004537 protein binding site [polypeptide binding]; other site 568703004538 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004539 putative substrate binding region [chemical binding]; other site 568703004540 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568703004541 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 568703004542 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 568703004543 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 568703004544 catalytic residue [active] 568703004545 putative FPP diphosphate binding site; other site 568703004546 putative FPP binding hydrophobic cleft; other site 568703004547 dimer interface [polypeptide binding]; other site 568703004548 putative IPP diphosphate binding site; other site 568703004549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703004550 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703004551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703004552 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703004553 putative transposase OrfB; Reviewed; Region: PHA02517 568703004554 HTH-like domain; Region: HTH_21; pfam13276 568703004555 Integrase core domain; Region: rve; pfam00665 568703004556 Integrase core domain; Region: rve_2; pfam13333 568703004557 ribosome recycling factor; Reviewed; Region: frr; PRK00083 568703004558 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 568703004559 hinge region; other site 568703004560 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568703004561 putative nucleotide binding site [chemical binding]; other site 568703004562 uridine monophosphate binding site [chemical binding]; other site 568703004563 homohexameric interface [polypeptide binding]; other site 568703004564 elongation factor Ts; Provisional; Region: tsf; PRK09377 568703004565 UBA/TS-N domain; Region: UBA; pfam00627 568703004566 Elongation factor TS; Region: EF_TS; pfam00889 568703004567 Elongation factor TS; Region: EF_TS; pfam00889 568703004568 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568703004569 rRNA interaction site [nucleotide binding]; other site 568703004570 S8 interaction site; other site 568703004571 putative laminin-1 binding site; other site 568703004572 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 568703004573 GIY-YIG motif/motif A; other site 568703004574 putative active site [active] 568703004575 putative metal binding site [ion binding]; other site 568703004576 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 568703004577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004578 S-adenosylmethionine binding site [chemical binding]; other site 568703004579 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703004580 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703004581 putative acyl-acceptor binding pocket; other site 568703004582 amino acid transporter; Region: 2A0306; TIGR00909 568703004583 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 568703004584 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 568703004585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004587 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 568703004588 Walker A/P-loop; other site 568703004589 ATP binding site [chemical binding]; other site 568703004590 Q-loop/lid; other site 568703004591 ABC transporter signature motif; other site 568703004592 Walker B; other site 568703004593 D-loop; other site 568703004594 H-loop/switch region; other site 568703004595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004596 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 568703004597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004598 Walker A/P-loop; other site 568703004599 ATP binding site [chemical binding]; other site 568703004600 Q-loop/lid; other site 568703004601 ABC transporter signature motif; other site 568703004602 Walker B; other site 568703004603 D-loop; other site 568703004604 H-loop/switch region; other site 568703004605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 568703004606 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 568703004607 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568703004608 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568703004609 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568703004610 RimM N-terminal domain; Region: RimM; pfam01782 568703004611 PRC-barrel domain; Region: PRC; pfam05239 568703004612 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 568703004613 KH domain; Region: KH_4; pfam13083 568703004614 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568703004615 signal recognition particle protein; Provisional; Region: PRK10867 568703004616 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568703004617 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004618 P loop; other site 568703004619 GTP binding site [chemical binding]; other site 568703004620 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568703004621 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 568703004622 putative DNA-binding protein; Validated; Region: PRK00118 568703004623 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568703004624 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 568703004625 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004626 P loop; other site 568703004627 GTP binding site [chemical binding]; other site 568703004628 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703004629 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568703004630 Walker A/P-loop; other site 568703004631 ATP binding site [chemical binding]; other site 568703004632 Q-loop/lid; other site 568703004633 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 568703004634 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568703004635 ABC transporter signature motif; other site 568703004636 Walker B; other site 568703004637 D-loop; other site 568703004638 H-loop/switch region; other site 568703004639 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 568703004640 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568703004641 dimerization interface [polypeptide binding]; other site 568703004642 active site 568703004643 metal binding site [ion binding]; metal-binding site 568703004644 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568703004645 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 568703004646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568703004647 peptide binding site [polypeptide binding]; other site 568703004648 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703004649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568703004650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703004651 dimer interface [polypeptide binding]; other site 568703004652 conserved gate region; other site 568703004653 putative PBP binding loops; other site 568703004654 ABC-ATPase subunit interface; other site 568703004655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703004657 dimer interface [polypeptide binding]; other site 568703004658 conserved gate region; other site 568703004659 putative PBP binding loops; other site 568703004660 ABC-ATPase subunit interface; other site 568703004661 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703004662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703004663 Walker A/P-loop; other site 568703004664 ATP binding site [chemical binding]; other site 568703004665 Q-loop/lid; other site 568703004666 ABC transporter signature motif; other site 568703004667 Walker B; other site 568703004668 D-loop; other site 568703004669 H-loop/switch region; other site 568703004670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703004671 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703004672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703004673 Walker A/P-loop; other site 568703004674 ATP binding site [chemical binding]; other site 568703004675 Q-loop/lid; other site 568703004676 ABC transporter signature motif; other site 568703004677 Walker B; other site 568703004678 D-loop; other site 568703004679 H-loop/switch region; other site 568703004680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703004681 acyl carrier protein; Provisional; Region: acpP; PRK00982 568703004682 putative phosphate acyltransferase; Provisional; Region: PRK05331 568703004683 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 568703004684 Y-family of DNA polymerases; Region: PolY; cl12025 568703004685 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 568703004686 generic binding surface II; other site 568703004687 ssDNA binding site; other site 568703004688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004689 ATP binding site [chemical binding]; other site 568703004690 putative Mg++ binding site [ion binding]; other site 568703004691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004692 nucleotide binding region [chemical binding]; other site 568703004693 ATP-binding site [chemical binding]; other site 568703004694 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 568703004695 DAK2 domain; Region: Dak2; pfam02734 568703004696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 568703004697 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568703004698 Thiamine pyrophosphokinase; Region: TPK; cd07995 568703004699 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 568703004700 active site 568703004701 dimerization interface [polypeptide binding]; other site 568703004702 thiamine binding site [chemical binding]; other site 568703004703 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568703004704 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568703004705 substrate binding site [chemical binding]; other site 568703004706 hexamer interface [polypeptide binding]; other site 568703004707 metal binding site [ion binding]; metal-binding site 568703004708 GTPase RsgA; Reviewed; Region: PRK00098 568703004709 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 568703004710 RNA binding site [nucleotide binding]; other site 568703004711 homodimer interface [polypeptide binding]; other site 568703004712 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 568703004713 GTPase/Zn-binding domain interface [polypeptide binding]; other site 568703004714 GTP/Mg2+ binding site [chemical binding]; other site 568703004715 G4 box; other site 568703004716 G5 box; other site 568703004717 G1 box; other site 568703004718 Switch I region; other site 568703004719 G2 box; other site 568703004720 G3 box; other site 568703004721 Switch II region; other site 568703004722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 568703004723 Catalytic domain of Protein Kinases; Region: PKc; cd00180 568703004724 active site 568703004725 ATP binding site [chemical binding]; other site 568703004726 substrate binding site [chemical binding]; other site 568703004727 activation loop (A-loop); other site 568703004728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 568703004729 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004730 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004731 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004732 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 568703004733 active site 568703004734 16S rRNA methyltransferase B; Provisional; Region: PRK14902 568703004735 NusB family; Region: NusB; pfam01029 568703004736 putative RNA binding site [nucleotide binding]; other site 568703004737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004738 S-adenosylmethionine binding site [chemical binding]; other site 568703004739 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568703004740 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568703004741 putative active site [active] 568703004742 substrate binding site [chemical binding]; other site 568703004743 putative cosubstrate binding site; other site 568703004744 catalytic site [active] 568703004745 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568703004746 substrate binding site [chemical binding]; other site 568703004747 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 568703004748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004749 ATP binding site [chemical binding]; other site 568703004750 putative Mg++ binding site [ion binding]; other site 568703004751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004752 nucleotide binding region [chemical binding]; other site 568703004753 ATP-binding site [chemical binding]; other site 568703004754 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568703004755 Flavoprotein; Region: Flavoprotein; pfam02441 568703004756 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 568703004757 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 568703004758 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568703004759 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568703004760 catalytic site [active] 568703004761 G-X2-G-X-G-K; other site 568703004762 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 568703004763 nucleophile elbow; other site 568703004764 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 568703004765 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568703004766 Walker A/P-loop; other site 568703004767 ATP binding site [chemical binding]; other site 568703004768 Q-loop/lid; other site 568703004769 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568703004770 ABC transporter signature motif; other site 568703004771 Walker B; other site 568703004772 D-loop; other site 568703004773 H-loop/switch region; other site 568703004774 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703004775 arginine repressor; Provisional; Region: PRK04280 568703004776 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703004777 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 568703004778 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703004779 RNA binding surface [nucleotide binding]; other site 568703004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004781 S-adenosylmethionine binding site [chemical binding]; other site 568703004782 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703004783 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703004784 substrate binding pocket [chemical binding]; other site 568703004785 chain length determination region; other site 568703004786 substrate-Mg2+ binding site; other site 568703004787 catalytic residues [active] 568703004788 aspartate-rich region 1; other site 568703004789 active site lid residues [active] 568703004790 aspartate-rich region 2; other site 568703004791 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 568703004792 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568703004793 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 568703004794 generic binding surface II; other site 568703004795 generic binding surface I; other site 568703004796 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 568703004797 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568703004798 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568703004799 homodimer interface [polypeptide binding]; other site 568703004800 NADP binding site [chemical binding]; other site 568703004801 substrate binding site [chemical binding]; other site 568703004802 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 568703004803 Asp23 family; Region: Asp23; pfam03780 568703004804 elongation factor P; Validated; Region: PRK00529 568703004805 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703004806 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568703004807 RNA binding site [nucleotide binding]; other site 568703004808 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568703004809 RNA binding site [nucleotide binding]; other site 568703004810 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703004811 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703004812 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703004813 active site 568703004814 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568703004815 Protein of unknown function (DUF464); Region: DUF464; pfam04327 568703004816 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568703004817 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004818 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703004819 Walker A/P-loop; other site 568703004820 ATP binding site [chemical binding]; other site 568703004821 Q-loop/lid; other site 568703004822 ABC transporter signature motif; other site 568703004823 Walker B; other site 568703004824 D-loop; other site 568703004825 H-loop/switch region; other site 568703004826 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 568703004827 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 568703004828 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 568703004829 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568703004830 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568703004831 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703004832 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703004833 DNA binding residues [nucleotide binding] 568703004834 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703004835 putative dimer interface [polypeptide binding]; other site 568703004836 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 568703004837 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703004838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703004839 catalytic residue [active] 568703004840 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568703004841 Aluminium resistance protein; Region: Alum_res; pfam06838 568703004842 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 568703004843 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568703004844 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568703004845 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 568703004846 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703004847 active site residue [active] 568703004848 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 568703004849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703004850 nucleotide binding site [chemical binding]; other site 568703004851 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 568703004852 Rhomboid family; Region: Rhomboid; pfam01694 568703004853 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703004854 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703004855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703004856 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703004857 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703004858 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 568703004859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703004860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703004861 active site 568703004862 phosphorylation site [posttranslational modification] 568703004863 intermolecular recognition site; other site 568703004864 dimerization interface [polypeptide binding]; other site 568703004865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703004866 DNA binding residues [nucleotide binding] 568703004867 dimerization interface [polypeptide binding]; other site 568703004868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004869 Histidine kinase; Region: HisKA_3; pfam07730 568703004870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004871 ATP binding site [chemical binding]; other site 568703004872 Mg2+ binding site [ion binding]; other site 568703004873 G-X-G motif; other site 568703004874 Predicted membrane protein [Function unknown]; Region: COG4758 568703004875 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 568703004876 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703004877 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568703004878 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568703004879 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 568703004880 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 568703004881 ATP-binding site [chemical binding]; other site 568703004882 Sugar specificity; other site 568703004883 Pyrimidine base specificity; other site 568703004884 YceG-like family; Region: YceG; pfam02618 568703004885 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568703004886 dimerization interface [polypeptide binding]; other site 568703004887 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568703004888 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703004889 putative tRNA-binding site [nucleotide binding]; other site 568703004890 B3/4 domain; Region: B3_4; pfam03483 568703004891 tRNA synthetase B5 domain; Region: B5; smart00874 568703004892 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568703004893 dimer interface [polypeptide binding]; other site 568703004894 motif 1; other site 568703004895 motif 3; other site 568703004896 motif 2; other site 568703004897 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 568703004898 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568703004899 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568703004900 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568703004901 dimer interface [polypeptide binding]; other site 568703004902 motif 1; other site 568703004903 active site 568703004904 motif 2; other site 568703004905 motif 3; other site 568703004906 Predicted transcriptional regulators [Transcription]; Region: COG1733 568703004907 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568703004908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004909 Zn2+ binding site [ion binding]; other site 568703004910 Mg2+ binding site [ion binding]; other site 568703004911 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568703004912 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568703004913 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568703004914 Acylphosphatase; Region: Acylphosphatase; pfam00708 568703004915 OxaA-like protein precursor; Provisional; Region: PRK02463 568703004916 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703004917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004918 HAMP domain; Region: HAMP; pfam00672 568703004919 dimerization interface [polypeptide binding]; other site 568703004920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703004921 dimer interface [polypeptide binding]; other site 568703004922 phosphorylation site [posttranslational modification] 568703004923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004924 ATP binding site [chemical binding]; other site 568703004925 Mg2+ binding site [ion binding]; other site 568703004926 G-X-G motif; other site 568703004927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703004928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703004929 active site 568703004930 phosphorylation site [posttranslational modification] 568703004931 intermolecular recognition site; other site 568703004932 dimerization interface [polypeptide binding]; other site 568703004933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703004934 DNA binding site [nucleotide binding] 568703004935 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703004936 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 568703004937 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568703004938 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568703004939 Peptidase family M23; Region: Peptidase_M23; pfam01551 568703004940 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 568703004941 Probable transposase; Region: OrfB_IS605; pfam01385 568703004942 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 568703004943 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 568703004944 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 568703004945 hypothetical protein; Provisional; Region: PRK13670 568703004946 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 568703004947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004948 S-adenosylmethionine binding site [chemical binding]; other site 568703004949 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 568703004950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004951 Zn2+ binding site [ion binding]; other site 568703004952 Mg2+ binding site [ion binding]; other site 568703004953 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 568703004954 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568703004955 active site 568703004956 (T/H)XGH motif; other site 568703004957 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 568703004958 GTPase YqeH; Provisional; Region: PRK13796 568703004959 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 568703004960 GTP/Mg2+ binding site [chemical binding]; other site 568703004961 G4 box; other site 568703004962 G5 box; other site 568703004963 G1 box; other site 568703004964 Switch I region; other site 568703004965 G2 box; other site 568703004966 G3 box; other site 568703004967 Switch II region; other site 568703004968 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 568703004969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703004970 active site 568703004971 motif I; other site 568703004972 motif II; other site 568703004973 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568703004975 Zn binding site [ion binding]; other site 568703004976 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004977 Zn binding site [ion binding]; other site 568703004978 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568703004980 Zn binding site [ion binding]; other site 568703004981 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004982 Zn binding site [ion binding]; other site 568703004983 Predicted esterase [General function prediction only]; Region: COG0400 568703004984 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703004985 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703004986 putative NAD(P) binding site [chemical binding]; other site 568703004987 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 568703004988 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568703004989 23S rRNA binding site [nucleotide binding]; other site 568703004990 L21 binding site [polypeptide binding]; other site 568703004991 L13 binding site [polypeptide binding]; other site 568703004992 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568703004993 translation initiation factor IF-3; Region: infC; TIGR00168 568703004994 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568703004995 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568703004996 Predicted transcriptional regulator [Transcription]; Region: COG1959 568703004997 Transcriptional regulator; Region: Rrf2; pfam02082 568703004998 Transcriptional regulator; Region: Rrf2; cl17282 568703004999 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005000 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005003 putative substrate translocation pore; other site 568703005004 NAD-dependent deacetylase; Provisional; Region: PRK14138 568703005005 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703005006 SseB protein; Region: SseB; cl06279 568703005007 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568703005008 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568703005009 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568703005010 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568703005011 active site 568703005012 dimer interface [polypeptide binding]; other site 568703005013 motif 1; other site 568703005014 motif 2; other site 568703005015 motif 3; other site 568703005016 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568703005017 anticodon binding site; other site 568703005018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005020 non-specific DNA binding site [nucleotide binding]; other site 568703005021 salt bridge; other site 568703005022 sequence-specific DNA binding site [nucleotide binding]; other site 568703005023 HNH endonuclease; Region: HNH_2; pfam13391 568703005024 primosomal protein DnaI; Reviewed; Region: PRK08939 568703005025 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 568703005026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005027 Walker A motif; other site 568703005028 ATP binding site [chemical binding]; other site 568703005029 Walker B motif; other site 568703005030 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 568703005031 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 568703005032 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568703005033 ATP cone domain; Region: ATP-cone; pfam03477 568703005034 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568703005035 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568703005036 CoA-binding site [chemical binding]; other site 568703005037 ATP-binding [chemical binding]; other site 568703005038 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568703005039 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568703005040 DNA binding site [nucleotide binding] 568703005041 catalytic residue [active] 568703005042 H2TH interface [polypeptide binding]; other site 568703005043 putative catalytic residues [active] 568703005044 turnover-facilitating residue; other site 568703005045 intercalation triad [nucleotide binding]; other site 568703005046 8OG recognition residue [nucleotide binding]; other site 568703005047 putative reading head residues; other site 568703005048 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568703005049 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703005050 DNA polymerase I; Provisional; Region: PRK05755 568703005051 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568703005052 active site 568703005053 metal binding site 1 [ion binding]; metal-binding site 568703005054 putative 5' ssDNA interaction site; other site 568703005055 metal binding site 3; metal-binding site 568703005056 metal binding site 2 [ion binding]; metal-binding site 568703005057 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568703005058 putative DNA binding site [nucleotide binding]; other site 568703005059 putative metal binding site [ion binding]; other site 568703005060 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 568703005061 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568703005062 active site 568703005063 DNA binding site [nucleotide binding] 568703005064 catalytic site [active] 568703005065 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568703005066 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568703005067 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703005068 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703005069 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703005070 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005071 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568703005072 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703005073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703005074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703005075 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568703005076 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005077 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 568703005078 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703005079 putative tRNA-binding site [nucleotide binding]; other site 568703005080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703005081 catalytic residues [active] 568703005082 Predicted small secreted protein [Function unknown]; Region: COG5584 568703005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703005084 S-adenosylmethionine binding site [chemical binding]; other site 568703005085 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 568703005086 Phosphotransferase enzyme family; Region: APH; pfam01636 568703005087 active site 568703005088 substrate binding site [chemical binding]; other site 568703005089 ATP binding site [chemical binding]; other site 568703005090 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 568703005091 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703005092 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703005093 Walker A/P-loop; other site 568703005094 ATP binding site [chemical binding]; other site 568703005095 Q-loop/lid; other site 568703005096 ABC transporter signature motif; other site 568703005097 Walker B; other site 568703005098 D-loop; other site 568703005099 H-loop/switch region; other site 568703005100 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 568703005101 HIT family signature motif; other site 568703005102 catalytic residue [active] 568703005103 YtxH-like protein; Region: YtxH; pfam12732 568703005104 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703005105 SurA N-terminal domain; Region: SurA_N_3; cl07813 568703005106 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568703005107 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 568703005108 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 568703005109 generic binding surface I; other site 568703005110 generic binding surface II; other site 568703005111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703005112 Zn2+ binding site [ion binding]; other site 568703005113 Mg2+ binding site [ion binding]; other site 568703005114 Protein of unknown function (DUF964); Region: DUF964; cl01483 568703005115 Transglycosylase; Region: Transgly; pfam00912 568703005116 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703005117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568703005118 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703005119 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703005120 active site 568703005121 Arginine repressor [Transcription]; Region: ArgR; COG1438 568703005122 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703005123 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703005124 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 568703005125 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 568703005126 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568703005127 active site 568703005128 HIGH motif; other site 568703005129 KMSK motif region; other site 568703005130 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 568703005131 tRNA binding surface [nucleotide binding]; other site 568703005132 anticodon binding site; other site 568703005133 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 568703005134 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 568703005135 active site 568703005136 FMN binding site [chemical binding]; other site 568703005137 substrate binding site [chemical binding]; other site 568703005138 catalytic residues [active] 568703005139 homodimer interface [polypeptide binding]; other site 568703005140 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 568703005141 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703005142 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 568703005143 putative active site [active] 568703005144 catalytic site [active] 568703005145 putative metal binding site [ion binding]; other site 568703005146 adaptor protein; Provisional; Region: PRK02315 568703005147 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 568703005148 ArsC family; Region: ArsC; pfam03960 568703005149 putative catalytic residues [active] 568703005150 thiol/disulfide switch; other site 568703005151 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 568703005152 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703005153 FtsX-like permease family; Region: FtsX; pfam02687 568703005154 FtsX-like permease family; Region: FtsX; pfam02687 568703005155 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005156 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005157 Walker A/P-loop; other site 568703005158 ATP binding site [chemical binding]; other site 568703005159 Q-loop/lid; other site 568703005160 ABC transporter signature motif; other site 568703005161 Walker B; other site 568703005162 D-loop; other site 568703005163 H-loop/switch region; other site 568703005164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703005165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703005166 active site 568703005167 phosphorylation site [posttranslational modification] 568703005168 intermolecular recognition site; other site 568703005169 dimerization interface [polypeptide binding]; other site 568703005170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703005171 DNA binding site [nucleotide binding] 568703005172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703005173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703005174 ATP binding site [chemical binding]; other site 568703005175 Mg2+ binding site [ion binding]; other site 568703005176 G-X-G motif; other site 568703005177 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 568703005178 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 568703005179 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 568703005180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703005181 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 568703005182 Penicillinase repressor; Region: Pencillinase_R; pfam03965 568703005183 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568703005184 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568703005185 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703005186 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568703005187 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568703005188 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 568703005189 purine monophosphate binding site [chemical binding]; other site 568703005190 dimer interface [polypeptide binding]; other site 568703005191 putative catalytic residues [active] 568703005192 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 568703005193 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568703005194 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568703005195 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568703005196 active site 568703005197 substrate binding site [chemical binding]; other site 568703005198 cosubstrate binding site; other site 568703005199 catalytic site [active] 568703005200 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568703005201 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568703005202 dimerization interface [polypeptide binding]; other site 568703005203 putative ATP binding site [chemical binding]; other site 568703005204 amidophosphoribosyltransferase; Provisional; Region: PRK07272 568703005205 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568703005206 active site 568703005207 tetramer interface [polypeptide binding]; other site 568703005208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703005209 active site 568703005210 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 568703005211 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568703005212 dimerization interface [polypeptide binding]; other site 568703005213 ATP binding site [chemical binding]; other site 568703005214 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 568703005215 dimerization interface [polypeptide binding]; other site 568703005216 ATP binding site [chemical binding]; other site 568703005217 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 568703005218 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568703005219 putative active site [active] 568703005220 catalytic triad [active] 568703005221 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 568703005222 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 568703005223 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 568703005224 ATP binding site [chemical binding]; other site 568703005225 active site 568703005226 substrate binding site [chemical binding]; other site 568703005227 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568703005228 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 568703005229 NAD binding site [chemical binding]; other site 568703005230 ATP-grasp domain; Region: ATP-grasp; pfam02222 568703005231 AIR carboxylase; Region: AIRC; pfam00731 568703005232 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 568703005233 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703005234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005235 putative substrate translocation pore; other site 568703005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005237 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 568703005238 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568703005239 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568703005240 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568703005241 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568703005242 dimerization domain swap beta strand [polypeptide binding]; other site 568703005243 regulatory protein interface [polypeptide binding]; other site 568703005244 active site 568703005245 regulatory phosphorylation site [posttranslational modification]; other site 568703005246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005247 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005248 Walker A motif; other site 568703005249 ATP binding site [chemical binding]; other site 568703005250 Walker B motif; other site 568703005251 arginine finger; other site 568703005252 UvrB/uvrC motif; Region: UVR; pfam02151 568703005253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005254 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005255 Walker A motif; other site 568703005256 ATP binding site [chemical binding]; other site 568703005257 Walker B motif; other site 568703005258 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703005259 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703005260 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568703005261 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568703005262 G1 box; other site 568703005263 putative GEF interaction site [polypeptide binding]; other site 568703005264 GTP/Mg2+ binding site [chemical binding]; other site 568703005265 Switch I region; other site 568703005266 G2 box; other site 568703005267 G3 box; other site 568703005268 Switch II region; other site 568703005269 G4 box; other site 568703005270 G5 box; other site 568703005271 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568703005272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568703005273 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703005274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703005275 Transporter associated domain; Region: CorC_HlyC; pfam03471 568703005276 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703005277 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568703005278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005279 Coenzyme A binding pocket [chemical binding]; other site 568703005280 hypothetical protein; Provisional; Region: PRK13662 568703005281 RecX family; Region: RecX; cl00936 568703005282 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005283 TRAM domain; Region: TRAM; pfam01938 568703005284 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703005285 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 568703005286 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703005287 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703005288 PYR/PP interface [polypeptide binding]; other site 568703005289 dimer interface [polypeptide binding]; other site 568703005290 tetramer interface [polypeptide binding]; other site 568703005291 TPP binding site [chemical binding]; other site 568703005292 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005293 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703005294 TPP-binding site [chemical binding]; other site 568703005295 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 568703005296 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 568703005297 dimer interface [polypeptide binding]; other site 568703005298 active site 568703005299 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 568703005300 homodimer interface [polypeptide binding]; other site 568703005301 catalytic residues [active] 568703005302 NAD binding site [chemical binding]; other site 568703005303 substrate binding pocket [chemical binding]; other site 568703005304 flexible flap; other site 568703005305 putative acyltransferase; Provisional; Region: PRK05790 568703005306 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568703005307 dimer interface [polypeptide binding]; other site 568703005308 active site 568703005309 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703005310 Restriction endonuclease; Region: Mrr_cat; pfam04471 568703005311 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 568703005312 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703005313 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703005314 metal binding site [ion binding]; metal-binding site 568703005315 dimer interface [polypeptide binding]; other site 568703005316 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703005317 Predicted membrane protein [Function unknown]; Region: COG4684 568703005318 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703005319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703005320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005321 Coenzyme A binding pocket [chemical binding]; other site 568703005322 hypothetical protein; Provisional; Region: PRK04351 568703005323 SprT homologues; Region: SprT; cl01182 568703005324 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703005325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005326 Walker A/P-loop; other site 568703005327 ATP binding site [chemical binding]; other site 568703005328 Q-loop/lid; other site 568703005329 ABC transporter signature motif; other site 568703005330 Walker B; other site 568703005331 D-loop; other site 568703005332 H-loop/switch region; other site 568703005333 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703005334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703005335 TM-ABC transporter signature motif; other site 568703005336 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703005337 zinc binding site [ion binding]; other site 568703005338 putative ligand binding site [chemical binding]; other site 568703005339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703005340 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703005341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703005342 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703005343 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703005344 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703005345 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703005346 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703005347 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 568703005348 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568703005349 homodimer interface [polypeptide binding]; other site 568703005350 NAD binding pocket [chemical binding]; other site 568703005351 ATP binding pocket [chemical binding]; other site 568703005352 Mg binding site [ion binding]; other site 568703005353 active-site loop [active] 568703005354 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703005355 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703005356 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703005357 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 568703005358 active site 568703005359 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703005360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005361 DNA-binding site [nucleotide binding]; DNA binding site 568703005362 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703005363 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 568703005364 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703005365 active site 568703005366 dimer interface [polypeptide binding]; other site 568703005367 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568703005368 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568703005369 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 568703005370 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703005371 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 568703005372 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 568703005373 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703005374 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005375 putative phosphoesterase; Region: acc_ester; TIGR03729 568703005376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703005377 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568703005378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005379 putative substrate translocation pore; other site 568703005380 POT family; Region: PTR2; pfam00854 568703005381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005383 Walker A/P-loop; other site 568703005384 ATP binding site [chemical binding]; other site 568703005385 Q-loop/lid; other site 568703005386 ABC transporter signature motif; other site 568703005387 Walker B; other site 568703005388 D-loop; other site 568703005389 H-loop/switch region; other site 568703005390 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703005391 FtsX-like permease family; Region: FtsX; pfam02687 568703005392 MFS/sugar transport protein; Region: MFS_2; pfam13347 568703005393 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703005394 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703005395 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703005396 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703005397 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 568703005398 active site 568703005399 nucleotide-binding site [chemical binding]; other site 568703005400 Virus attachment protein p12 family; Region: P12; pfam12669 568703005401 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 568703005402 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 568703005403 G1 box; other site 568703005404 GTP/Mg2+ binding site [chemical binding]; other site 568703005405 Switch I region; other site 568703005406 G2 box; other site 568703005407 G3 box; other site 568703005408 Switch II region; other site 568703005409 G4 box; other site 568703005410 G5 box; other site 568703005411 Nucleoside recognition; Region: Gate; pfam07670 568703005412 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 568703005413 Nucleoside recognition; Region: Gate; pfam07670 568703005414 FeoA domain; Region: FeoA; pfam04023 568703005415 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 568703005416 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005417 catalytic triad [active] 568703005418 catalytic triad [active] 568703005419 oxyanion hole [active] 568703005420 AAA domain; Region: AAA_17; cl17253 568703005421 AAA domain; Region: AAA_18; pfam13238 568703005422 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703005423 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703005424 NAD binding site [chemical binding]; other site 568703005425 substrate binding site [chemical binding]; other site 568703005426 putative active site [active] 568703005427 seryl-tRNA synthetase; Provisional; Region: PRK05431 568703005428 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568703005429 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568703005430 dimer interface [polypeptide binding]; other site 568703005431 active site 568703005432 motif 1; other site 568703005433 motif 2; other site 568703005434 motif 3; other site 568703005435 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005436 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005437 lysine transporter; Provisional; Region: PRK10836 568703005438 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 568703005439 acetolactate synthase; Reviewed; Region: PRK08617 568703005440 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703005441 PYR/PP interface [polypeptide binding]; other site 568703005442 dimer interface [polypeptide binding]; other site 568703005443 TPP binding site [chemical binding]; other site 568703005444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005445 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 568703005446 TPP-binding site [chemical binding]; other site 568703005447 dimer interface [polypeptide binding]; other site 568703005448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703005449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703005450 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703005451 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703005452 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568703005453 Fic family protein [Function unknown]; Region: COG3177 568703005454 Fic/DOC family; Region: Fic; pfam02661 568703005455 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703005456 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703005457 active site 568703005458 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703005459 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703005460 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 568703005461 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703005462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005463 DNA-binding site [nucleotide binding]; DNA binding site 568703005464 FCD domain; Region: FCD; pfam07729 568703005465 oxaloacetate decarboxylase; Provisional; Region: PRK12331 568703005466 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703005467 active site 568703005468 catalytic residues [active] 568703005469 metal binding site [ion binding]; metal-binding site 568703005470 homodimer binding site [polypeptide binding]; other site 568703005471 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 568703005472 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 568703005473 Coenzyme A transferase; Region: CoA_trans; cl17247 568703005474 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568703005475 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568703005476 citrate lyase subunit gamma; Provisional; Region: PRK13253 568703005477 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 568703005478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703005479 active site 568703005480 nucleotide binding site [chemical binding]; other site 568703005481 HIGH motif; other site 568703005482 KMSKS motif; other site 568703005483 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 568703005484 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 568703005485 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703005486 carboxyltransferase (CT) interaction site; other site 568703005487 biotinylation site [posttranslational modification]; other site 568703005488 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 568703005489 Citrate transporter; Region: CitMHS; pfam03600 568703005490 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 568703005491 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 568703005492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703005493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005494 Coenzyme A binding pocket [chemical binding]; other site 568703005495 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703005496 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703005497 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703005498 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703005499 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 568703005500 dimer interface [polypeptide binding]; other site 568703005501 FMN binding site [chemical binding]; other site 568703005502 NADPH bind site [chemical binding]; other site 568703005503 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703005504 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703005505 Walker A/P-loop; other site 568703005506 ATP binding site [chemical binding]; other site 568703005507 Q-loop/lid; other site 568703005508 ABC transporter signature motif; other site 568703005509 Walker B; other site 568703005510 D-loop; other site 568703005511 H-loop/switch region; other site 568703005512 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 568703005513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703005514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703005515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005517 putative substrate translocation pore; other site 568703005518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005519 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703005520 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005522 non-specific DNA binding site [nucleotide binding]; other site 568703005523 salt bridge; other site 568703005524 sequence-specific DNA binding site [nucleotide binding]; other site 568703005525 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703005526 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703005527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005528 DNA-binding site [nucleotide binding]; DNA binding site 568703005529 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703005530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005531 Walker A/P-loop; other site 568703005532 ATP binding site [chemical binding]; other site 568703005533 Q-loop/lid; other site 568703005534 ABC transporter signature motif; other site 568703005535 Walker B; other site 568703005536 D-loop; other site 568703005537 H-loop/switch region; other site 568703005538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005540 Walker A/P-loop; other site 568703005541 ATP binding site [chemical binding]; other site 568703005542 Q-loop/lid; other site 568703005543 ABC transporter signature motif; other site 568703005544 Walker B; other site 568703005545 D-loop; other site 568703005546 H-loop/switch region; other site 568703005547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703005548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005550 Walker A/P-loop; other site 568703005551 ATP binding site [chemical binding]; other site 568703005552 Q-loop/lid; other site 568703005553 ABC transporter signature motif; other site 568703005554 Walker B; other site 568703005555 D-loop; other site 568703005556 H-loop/switch region; other site 568703005557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005558 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568703005559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005560 dimer interface [polypeptide binding]; other site 568703005561 conserved gate region; other site 568703005562 putative PBP binding loops; other site 568703005563 ABC-ATPase subunit interface; other site 568703005564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005566 dimer interface [polypeptide binding]; other site 568703005567 conserved gate region; other site 568703005568 putative PBP binding loops; other site 568703005569 ABC-ATPase subunit interface; other site 568703005570 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005571 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005572 peptide binding site [polypeptide binding]; other site 568703005573 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005576 Walker A/P-loop; other site 568703005577 ATP binding site [chemical binding]; other site 568703005578 Q-loop/lid; other site 568703005579 ABC transporter signature motif; other site 568703005580 Walker B; other site 568703005581 D-loop; other site 568703005582 H-loop/switch region; other site 568703005583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703005585 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703005586 Walker A/P-loop; other site 568703005587 ATP binding site [chemical binding]; other site 568703005588 Q-loop/lid; other site 568703005589 ABC transporter signature motif; other site 568703005590 Walker B; other site 568703005591 D-loop; other site 568703005592 H-loop/switch region; other site 568703005593 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 568703005594 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 568703005595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703005596 ATP binding site [chemical binding]; other site 568703005597 putative Mg++ binding site [ion binding]; other site 568703005598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 568703005599 nucleotide binding region [chemical binding]; other site 568703005600 ATP-binding site [chemical binding]; other site 568703005601 Phosphotransferase enzyme family; Region: APH; pfam01636 568703005602 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 568703005603 substrate binding site [chemical binding]; other site 568703005604 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 568703005605 active site 568703005606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703005607 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005609 non-specific DNA binding site [nucleotide binding]; other site 568703005610 salt bridge; other site 568703005611 sequence-specific DNA binding site [nucleotide binding]; other site 568703005612 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 568703005613 putative active site [active] 568703005614 putative NTP binding site [chemical binding]; other site 568703005615 putative nucleic acid binding site [nucleotide binding]; other site 568703005616 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005617 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703005619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568703005620 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 568703005621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568703005622 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 568703005623 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 568703005624 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005625 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005626 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 568703005627 GMP synthase; Reviewed; Region: guaA; PRK00074 568703005628 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568703005629 AMP/PPi binding site [chemical binding]; other site 568703005630 candidate oxyanion hole; other site 568703005631 catalytic triad [active] 568703005632 potential glutamine specificity residues [chemical binding]; other site 568703005633 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568703005634 ATP Binding subdomain [chemical binding]; other site 568703005635 Dimerization subdomain; other site 568703005636 pantothenate kinase; Provisional; Region: PRK05439 568703005637 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 568703005638 ATP-binding site [chemical binding]; other site 568703005639 CoA-binding site [chemical binding]; other site 568703005640 Mg2+-binding site [ion binding]; other site 568703005641 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703005642 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568703005643 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703005644 Part of AAA domain; Region: AAA_19; pfam13245 568703005645 Family description; Region: UvrD_C_2; pfam13538 568703005646 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703005647 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568703005648 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 568703005649 TrkA-C domain; Region: TrkA_C; pfam02080 568703005650 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703005651 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 568703005652 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568703005653 Ferrochelatase; Region: Ferrochelatase; pfam00762 568703005654 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568703005655 C-terminal domain interface [polypeptide binding]; other site 568703005656 active site 568703005657 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568703005658 active site 568703005659 N-terminal domain interface [polypeptide binding]; other site 568703005660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005661 catalytic core [active] 568703005662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005663 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 568703005664 intersubunit interface [polypeptide binding]; other site 568703005665 active site 568703005666 Zn2+ binding site [ion binding]; other site 568703005667 FtsX-like permease family; Region: FtsX; pfam02687 568703005668 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005669 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005670 Walker A/P-loop; other site 568703005671 ATP binding site [chemical binding]; other site 568703005672 Q-loop/lid; other site 568703005673 ABC transporter signature motif; other site 568703005674 Walker B; other site 568703005675 D-loop; other site 568703005676 H-loop/switch region; other site 568703005677 Amino acid permease; Region: AA_permease_2; pfam13520 568703005678 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703005679 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703005680 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 568703005681 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 568703005682 HflX GTPase family; Region: HflX; cd01878 568703005683 G1 box; other site 568703005684 GTP/Mg2+ binding site [chemical binding]; other site 568703005685 Switch I region; other site 568703005686 G2 box; other site 568703005687 G3 box; other site 568703005688 Switch II region; other site 568703005689 G4 box; other site 568703005690 G5 box; other site 568703005691 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568703005692 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 568703005693 NodB motif; other site 568703005694 active site 568703005695 catalytic site [active] 568703005696 Zn binding site [ion binding]; other site 568703005697 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005698 active site 568703005699 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005700 homodimer interface [polypeptide binding]; other site 568703005701 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 568703005702 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 568703005703 NADP binding site [chemical binding]; other site 568703005704 active site 568703005705 putative substrate binding site [chemical binding]; other site 568703005706 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005707 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005708 NAD binding site [chemical binding]; other site 568703005709 substrate binding site [chemical binding]; other site 568703005710 homodimer interface [polypeptide binding]; other site 568703005711 active site 568703005712 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 568703005713 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 568703005714 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 568703005715 substrate binding site; other site 568703005716 tetramer interface; other site 568703005717 SH3-like domain; Region: SH3_8; pfam13457 568703005718 SH3-like domain; Region: SH3_8; pfam13457 568703005719 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 568703005720 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703005721 active site 568703005722 SH3-like domain; Region: SH3_8; pfam13457 568703005723 SH3-like domain; Region: SH3_8; pfam13457 568703005724 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 568703005725 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005726 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005727 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 568703005728 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568703005729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005730 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568703005731 NAD(P) binding site [chemical binding]; other site 568703005732 active site 568703005733 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005735 dimer interface [polypeptide binding]; other site 568703005736 conserved gate region; other site 568703005737 putative PBP binding loops; other site 568703005738 ABC-ATPase subunit interface; other site 568703005739 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005741 dimer interface [polypeptide binding]; other site 568703005742 conserved gate region; other site 568703005743 putative PBP binding loops; other site 568703005744 ABC-ATPase subunit interface; other site 568703005745 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703005746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703005747 substrate binding pocket [chemical binding]; other site 568703005748 membrane-bound complex binding site; other site 568703005749 hinge residues; other site 568703005750 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703005751 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703005752 Walker A/P-loop; other site 568703005753 ATP binding site [chemical binding]; other site 568703005754 Q-loop/lid; other site 568703005755 ABC transporter signature motif; other site 568703005756 Walker B; other site 568703005757 D-loop; other site 568703005758 H-loop/switch region; other site 568703005759 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703005760 metal binding site 2 [ion binding]; metal-binding site 568703005761 putative DNA binding helix; other site 568703005762 metal binding site 1 [ion binding]; metal-binding site 568703005763 dimer interface [polypeptide binding]; other site 568703005764 structural Zn2+ binding site [ion binding]; other site 568703005765 Guanylate kinase; Region: Guanylate_kin; pfam00625 568703005766 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568703005767 catalytic site [active] 568703005768 G-X2-G-X-G-K; other site 568703005769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005770 Coenzyme A binding pocket [chemical binding]; other site 568703005771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703005772 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 568703005773 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568703005774 NlpC/P60 family; Region: NLPC_P60; pfam00877 568703005775 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 568703005776 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568703005777 active site 568703005778 HIGH motif; other site 568703005779 dimer interface [polypeptide binding]; other site 568703005780 KMSKS motif; other site 568703005781 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703005782 RNA binding surface [nucleotide binding]; other site 568703005783 Cation efflux family; Region: Cation_efflux; cl00316 568703005784 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703005785 Cation efflux family; Region: Cation_efflux; cl00316 568703005786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703005787 dimerization interface [polypeptide binding]; other site 568703005788 putative DNA binding site [nucleotide binding]; other site 568703005789 putative Zn2+ binding site [ion binding]; other site 568703005790 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703005791 ApbE family; Region: ApbE; pfam02424 568703005792 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 568703005793 active site 568703005794 homodimer interface [polypeptide binding]; other site 568703005795 catalytic site [active] 568703005796 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 568703005797 homodimer interface [polypeptide binding]; other site 568703005798 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 568703005799 active site pocket [active] 568703005800 glycogen synthase; Provisional; Region: glgA; PRK00654 568703005801 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 568703005802 ADP-binding pocket [chemical binding]; other site 568703005803 homodimer interface [polypeptide binding]; other site 568703005804 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 568703005805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005806 active site 568703005807 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 568703005808 dimer interface [polypeptide binding]; other site 568703005809 N-terminal domain interface [polypeptide binding]; other site 568703005810 sulfate 1 binding site; other site 568703005811 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 568703005812 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 568703005813 ligand binding site; other site 568703005814 oligomer interface; other site 568703005815 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 568703005816 dimer interface [polypeptide binding]; other site 568703005817 N-terminal domain interface [polypeptide binding]; other site 568703005818 sulfate 1 binding site; other site 568703005819 glycogen branching enzyme; Provisional; Region: PRK12313 568703005820 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 568703005821 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 568703005822 active site 568703005823 catalytic site [active] 568703005824 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 568703005825 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 568703005826 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 568703005827 homodimer interface [polypeptide binding]; other site 568703005828 substrate-cofactor binding pocket; other site 568703005829 catalytic residue [active] 568703005830 Sortase family; Region: Sortase; pfam04203 568703005831 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703005832 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703005833 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703005834 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 568703005835 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005836 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005837 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 568703005838 ArsC family; Region: ArsC; pfam03960 568703005839 putative catalytic residues [active] 568703005840 thiol/disulfide switch; other site 568703005841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005842 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005843 Walker A motif; other site 568703005844 ATP binding site [chemical binding]; other site 568703005845 Walker B motif; other site 568703005846 arginine finger; other site 568703005847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005848 Walker A motif; other site 568703005849 ATP binding site [chemical binding]; other site 568703005850 Walker B motif; other site 568703005851 arginine finger; other site 568703005852 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568703005853 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 568703005854 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703005855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005857 NAD binding site [chemical binding]; other site 568703005858 substrate binding site [chemical binding]; other site 568703005859 homodimer interface [polypeptide binding]; other site 568703005860 active site 568703005861 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 568703005862 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005863 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005864 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005866 active site 568703005867 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568703005868 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703005869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703005870 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 568703005871 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703005872 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703005873 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703005874 Probable Catalytic site; other site 568703005875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703005876 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 568703005877 putative ADP-binding pocket [chemical binding]; other site 568703005878 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 568703005879 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703005880 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 568703005881 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 568703005882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568703005883 UDP-galactopyranose mutase; Region: GLF; pfam03275 568703005884 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 568703005885 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 568703005886 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568703005887 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 568703005888 Chain length determinant protein; Region: Wzz; cl15801 568703005889 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005890 catalytic triad [active] 568703005891 catalytic triad [active] 568703005892 oxyanion hole [active] 568703005893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005894 non-specific DNA binding site [nucleotide binding]; other site 568703005895 salt bridge; other site 568703005896 sequence-specific DNA binding site [nucleotide binding]; other site 568703005897 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 568703005898 QueT transporter; Region: QueT; pfam06177 568703005899 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 568703005900 classical (c) SDRs; Region: SDR_c; cd05233 568703005901 NAD(P) binding site [chemical binding]; other site 568703005902 active site 568703005903 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 568703005904 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005906 non-specific DNA binding site [nucleotide binding]; other site 568703005907 salt bridge; other site 568703005908 sequence-specific DNA binding site [nucleotide binding]; other site 568703005909 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005910 catalytic core [active] 568703005911 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005913 Walker A/P-loop; other site 568703005914 ATP binding site [chemical binding]; other site 568703005915 Q-loop/lid; other site 568703005916 ABC transporter signature motif; other site 568703005917 Walker B; other site 568703005918 D-loop; other site 568703005919 H-loop/switch region; other site 568703005920 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703005921 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005922 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005923 Walker A/P-loop; other site 568703005924 ATP binding site [chemical binding]; other site 568703005925 Q-loop/lid; other site 568703005926 ABC transporter signature motif; other site 568703005927 Walker B; other site 568703005928 D-loop; other site 568703005929 H-loop/switch region; other site 568703005930 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568703005931 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703005932 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568703005933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005934 dimer interface [polypeptide binding]; other site 568703005935 conserved gate region; other site 568703005936 putative PBP binding loops; other site 568703005937 ABC-ATPase subunit interface; other site 568703005938 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005940 dimer interface [polypeptide binding]; other site 568703005941 conserved gate region; other site 568703005942 putative PBP binding loops; other site 568703005943 ABC-ATPase subunit interface; other site 568703005944 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005945 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005946 peptide binding site [polypeptide binding]; other site 568703005947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005949 putative substrate translocation pore; other site 568703005950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005951 elongation factor P; Validated; Region: PRK00529 568703005952 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703005953 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568703005954 RNA binding site [nucleotide binding]; other site 568703005955 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568703005956 RNA binding site [nucleotide binding]; other site 568703005957 Uncharacterized conserved protein [Function unknown]; Region: COG1556 568703005958 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 568703005959 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 568703005960 4Fe-4S binding domain; Region: Fer4; pfam00037 568703005961 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 568703005962 Cysteine-rich domain; Region: CCG; pfam02754 568703005963 Cysteine-rich domain; Region: CCG; pfam02754 568703005964 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703005965 active site 568703005966 methionine cluster; other site 568703005967 phosphorylation site [posttranslational modification] 568703005968 metal binding site [ion binding]; metal-binding site 568703005969 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703005970 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703005971 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703005972 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703005973 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703005974 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703005975 Melibiase; Region: Melibiase; pfam02065 568703005976 hypothetical protein; Validated; Region: PRK02101 568703005977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703005978 DNA binding residues [nucleotide binding] 568703005979 Winged helix-turn helix; Region: HTH_29; pfam13551 568703005980 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 568703005981 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 568703005982 AAA domain; Region: AAA_30; pfam13604 568703005983 Family description; Region: UvrD_C_2; pfam13538 568703005984 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703005985 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703005986 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 568703005987 substrate binding site [chemical binding]; other site 568703005988 ATP binding site [chemical binding]; other site 568703005989 Predicted periplasmic protein [Function unknown]; Region: COG3698 568703005990 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 568703005991 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 568703005992 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703005993 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703005994 active site 568703005995 metal binding site [ion binding]; metal-binding site 568703005996 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 568703005997 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568703005998 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568703005999 Uncharacterized conserved protein [Function unknown]; Region: COG3535 568703006000 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 568703006001 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 568703006002 Na binding site [ion binding]; other site 568703006003 Protein of unknown function DUF262; Region: DUF262; pfam03235 568703006004 Uncharacterized conserved protein [Function unknown]; Region: COG1479 568703006005 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 568703006006 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 568703006007 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 568703006008 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568703006009 TIGR02687 family protein; Region: TIGR02687 568703006010 PglZ domain; Region: PglZ; pfam08665 568703006011 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 568703006012 integrase; Provisional; Region: int; PHA02601 568703006013 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703006014 Int/Topo IB signature motif; other site 568703006015 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568703006016 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 568703006017 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 568703006018 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 568703006019 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 568703006020 Protein of unknown function (DUF998); Region: DUF998; pfam06197 568703006021 Predicted membrane protein [Function unknown]; Region: COG3371 568703006022 Predicted membrane protein [Function unknown]; Region: COG1511 568703006023 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703006024 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703006025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703006026 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703006027 HPr interaction site; other site 568703006028 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703006029 active site 568703006030 phosphorylation site [posttranslational modification] 568703006031 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703006032 active site turn [active] 568703006033 phosphorylation site [posttranslational modification] 568703006034 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703006035 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703006036 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703006037 Ca binding site [ion binding]; other site 568703006038 active site 568703006039 catalytic site [active] 568703006040 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703006041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703006042 DNA binding site [nucleotide binding] 568703006043 domain linker motif; other site 568703006044 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568703006045 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 568703006046 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 568703006047 substrate binding [chemical binding]; other site 568703006048 active site 568703006049 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 568703006050 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 568703006051 NmrA-like family; Region: NmrA; pfam05368 568703006052 NADP binding site [chemical binding]; other site 568703006053 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 568703006054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006055 S-adenosylmethionine binding site [chemical binding]; other site 568703006056 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 568703006057 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568703006058 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568703006059 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568703006060 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703006061 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703006062 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568703006063 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703006064 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703006065 carboxyltransferase (CT) interaction site; other site 568703006066 biotinylation site [posttranslational modification]; other site 568703006067 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 568703006068 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568703006069 dimer interface [polypeptide binding]; other site 568703006070 active site 568703006071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568703006072 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568703006073 NAD(P) binding site [chemical binding]; other site 568703006074 homotetramer interface [polypeptide binding]; other site 568703006075 homodimer interface [polypeptide binding]; other site 568703006076 active site 568703006077 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568703006078 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568703006079 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 568703006080 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 568703006081 FMN binding site [chemical binding]; other site 568703006082 substrate binding site [chemical binding]; other site 568703006083 putative catalytic residue [active] 568703006084 acyl carrier protein; Provisional; Region: acpP; PRK00982 568703006085 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568703006086 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568703006087 dimer interface [polypeptide binding]; other site 568703006088 active site 568703006089 CoA binding pocket [chemical binding]; other site 568703006090 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703006091 MarR family; Region: MarR_2; pfam12802 568703006092 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703006093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568703006094 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 568703006095 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 568703006096 dimer interface [polypeptide binding]; other site 568703006097 active site 568703006098 metal binding site [ion binding]; metal-binding site 568703006099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568703006100 active site residue [active] 568703006101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703006102 MarR family; Region: MarR_2; pfam12802 568703006103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703006104 MarR family; Region: MarR_2; pfam12802 568703006105 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 568703006106 Putative esterase; Region: Esterase; pfam00756 568703006107 S-formylglutathione hydrolase; Region: PLN02442 568703006108 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568703006109 Double zinc ribbon; Region: DZR; pfam12773 568703006110 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703006111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006112 putative Zn2+ binding site [ion binding]; other site 568703006113 putative DNA binding site [nucleotide binding]; other site 568703006114 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703006115 nudix motif; other site 568703006116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006117 catalytic core [active] 568703006118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006119 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568703006120 Double zinc ribbon; Region: DZR; pfam12773 568703006121 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703006122 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703006123 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703006124 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 568703006125 active site 568703006126 catalytic site [active] 568703006127 Predicted membrane protein [Function unknown]; Region: COG2246 568703006128 GtrA-like protein; Region: GtrA; pfam04138 568703006129 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703006130 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703006131 PYR/PP interface [polypeptide binding]; other site 568703006132 tetramer interface [polypeptide binding]; other site 568703006133 dimer interface [polypeptide binding]; other site 568703006134 TPP binding site [chemical binding]; other site 568703006135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703006136 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703006137 TPP-binding site [chemical binding]; other site 568703006138 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 568703006139 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703006140 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703006141 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 568703006142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703006143 dimer interface [polypeptide binding]; other site 568703006144 conserved gate region; other site 568703006145 putative PBP binding loops; other site 568703006146 ABC-ATPase subunit interface; other site 568703006147 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 568703006148 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 568703006149 Walker A/P-loop; other site 568703006150 ATP binding site [chemical binding]; other site 568703006151 Q-loop/lid; other site 568703006152 ABC transporter signature motif; other site 568703006153 Walker B; other site 568703006154 D-loop; other site 568703006155 H-loop/switch region; other site 568703006156 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703006157 Sugar fermentation stimulation protein; Region: SfsA; cl00647 568703006158 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703006159 Ligand Binding Site [chemical binding]; other site 568703006160 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 568703006161 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 568703006162 homoserine kinase; Provisional; Region: PRK01212 568703006163 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703006164 threonine synthase; Validated; Region: PRK09225 568703006165 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568703006166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703006167 catalytic residue [active] 568703006168 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 568703006169 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568703006170 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568703006171 aspartate kinase; Reviewed; Region: PRK09034 568703006172 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 568703006173 nucleotide binding site [chemical binding]; other site 568703006174 substrate binding site [chemical binding]; other site 568703006175 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703006176 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 568703006178 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 568703006179 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 568703006180 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703006181 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703006182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703006183 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703006184 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703006185 D-lactate dehydrogenase; Validated; Region: PRK08605 568703006186 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 568703006187 homodimer interface [polypeptide binding]; other site 568703006188 ligand binding site [chemical binding]; other site 568703006189 NAD binding site [chemical binding]; other site 568703006190 catalytic site [active] 568703006191 aromatic amino acid aminotransferase; Validated; Region: PRK07309 568703006192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703006193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703006194 homodimer interface [polypeptide binding]; other site 568703006195 catalytic residue [active] 568703006196 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703006197 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703006198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703006199 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 568703006200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703006201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703006202 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 568703006203 Predicted membrane protein [Function unknown]; Region: COG1511 568703006204 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703006205 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703006206 Transposase domain (DUF772); Region: DUF772; pfam05598 568703006207 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703006208 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006209 Cation efflux family; Region: Cation_efflux; pfam01545 568703006210 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 568703006211 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568703006212 active site 568703006213 dimer interface [polypeptide binding]; other site 568703006214 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568703006215 Ligand Binding Site [chemical binding]; other site 568703006216 Molecular Tunnel; other site 568703006217 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 568703006218 conserved cys residue [active] 568703006219 HNH endonuclease; Region: HNH_5; pfam14279 568703006220 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 568703006221 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703006222 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703006223 active site 568703006224 metal binding site [ion binding]; metal-binding site 568703006225 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 568703006226 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006227 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703006228 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703006229 substrate binding pocket [chemical binding]; other site 568703006230 chain length determination region; other site 568703006231 substrate-Mg2+ binding site; other site 568703006232 catalytic residues [active] 568703006233 aspartate-rich region 1; other site 568703006234 active site lid residues [active] 568703006235 aspartate-rich region 2; other site 568703006236 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568703006237 propionate/acetate kinase; Provisional; Region: PRK12379 568703006238 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703006239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006240 Walker A/P-loop; other site 568703006241 ATP binding site [chemical binding]; other site 568703006242 Q-loop/lid; other site 568703006243 ABC transporter signature motif; other site 568703006244 Walker B; other site 568703006245 D-loop; other site 568703006246 H-loop/switch region; other site 568703006247 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 568703006248 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703006249 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703006250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006251 DNA-binding site [nucleotide binding]; DNA binding site 568703006252 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006254 Walker A/P-loop; other site 568703006255 ATP binding site [chemical binding]; other site 568703006256 Q-loop/lid; other site 568703006257 ABC transporter signature motif; other site 568703006258 Walker B; other site 568703006259 D-loop; other site 568703006260 H-loop/switch region; other site 568703006261 glucose-1-dehydrogenase; Provisional; Region: PRK08936 568703006262 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 568703006263 NAD binding site [chemical binding]; other site 568703006264 homodimer interface [polypeptide binding]; other site 568703006265 active site 568703006266 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703006267 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703006268 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703006269 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703006270 active site turn [active] 568703006271 phosphorylation site [posttranslational modification] 568703006272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703006273 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 568703006274 HPr interaction site; other site 568703006275 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703006276 active site 568703006277 phosphorylation site [posttranslational modification] 568703006278 transcriptional antiterminator BglG; Provisional; Region: PRK09772 568703006279 CAT RNA binding domain; Region: CAT_RBD; smart01061 568703006280 PRD domain; Region: PRD; pfam00874 568703006281 PRD domain; Region: PRD; pfam00874 568703006282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006284 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703006285 Walker A/P-loop; other site 568703006286 ATP binding site [chemical binding]; other site 568703006287 Q-loop/lid; other site 568703006288 ABC transporter signature motif; other site 568703006289 Walker B; other site 568703006290 D-loop; other site 568703006291 H-loop/switch region; other site 568703006292 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703006293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006295 Walker A/P-loop; other site 568703006296 ATP binding site [chemical binding]; other site 568703006297 Q-loop/lid; other site 568703006298 ABC transporter signature motif; other site 568703006299 Walker B; other site 568703006300 D-loop; other site 568703006301 H-loop/switch region; other site 568703006302 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703006303 trimer interface [polypeptide binding]; other site 568703006304 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 568703006305 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 568703006306 tetramer interface [polypeptide binding]; other site 568703006307 putative DNA binding site [nucleotide binding]; other site 568703006308 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 568703006309 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 568703006310 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 568703006311 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 568703006312 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 568703006313 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006314 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 568703006315 Walker A/P-loop; other site 568703006316 ATP binding site [chemical binding]; other site 568703006317 Q-loop/lid; other site 568703006318 ABC transporter signature motif; other site 568703006319 Walker B; other site 568703006320 D-loop; other site 568703006321 H-loop/switch region; other site 568703006322 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703006323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006325 Walker A/P-loop; other site 568703006326 ATP binding site [chemical binding]; other site 568703006327 Q-loop/lid; other site 568703006328 ABC transporter signature motif; other site 568703006329 Walker B; other site 568703006330 D-loop; other site 568703006331 H-loop/switch region; other site 568703006332 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703006333 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703006334 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703006335 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568703006336 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703006337 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 568703006338 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703006339 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 568703006340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703006341 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 568703006342 active site 568703006343 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568703006344 EamA-like transporter family; Region: EamA; pfam00892 568703006345 EamA-like transporter family; Region: EamA; pfam00892 568703006346 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568703006347 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703006348 Ligand Binding Site [chemical binding]; other site 568703006349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703006350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006351 non-specific DNA binding site [nucleotide binding]; other site 568703006352 salt bridge; other site 568703006353 sequence-specific DNA binding site [nucleotide binding]; other site 568703006354 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 568703006355 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 568703006356 epoxyqueuosine reductase; Region: TIGR00276 568703006357 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 568703006358 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 568703006359 protein binding surface [polypeptide binding]; other site 568703006360 BioY family; Region: BioY; pfam02632 568703006361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006362 S-adenosylmethionine binding site [chemical binding]; other site 568703006363 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568703006364 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703006365 catalytic triad [active] 568703006366 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 568703006367 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 568703006368 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703006369 FOG: CBS domain [General function prediction only]; Region: COG0517 568703006370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703006371 Transporter associated domain; Region: CorC_HlyC; smart01091 568703006372 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703006373 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 568703006374 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703006375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703006377 Maf-like protein; Region: Maf; pfam02545 568703006378 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568703006379 active site 568703006380 dimer interface [polypeptide binding]; other site 568703006381 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 568703006382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703006383 ATP binding site [chemical binding]; other site 568703006384 Mg2+ binding site [ion binding]; other site 568703006385 G-X-G motif; other site 568703006386 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 568703006387 ATP binding site [chemical binding]; other site 568703006388 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 568703006389 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568703006390 MutS domain I; Region: MutS_I; pfam01624 568703006391 MutS domain II; Region: MutS_II; pfam05188 568703006392 MutS domain III; Region: MutS_III; pfam05192 568703006393 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 568703006394 Walker A/P-loop; other site 568703006395 ATP binding site [chemical binding]; other site 568703006396 Q-loop/lid; other site 568703006397 ABC transporter signature motif; other site 568703006398 Walker B; other site 568703006399 D-loop; other site 568703006400 H-loop/switch region; other site 568703006401 Amino acid permease; Region: AA_permease_2; pfam13520 568703006402 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703006403 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568703006404 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568703006405 ring oligomerisation interface [polypeptide binding]; other site 568703006406 ATP/Mg binding site [chemical binding]; other site 568703006407 stacking interactions; other site 568703006408 hinge regions; other site 568703006409 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568703006410 oligomerisation interface [polypeptide binding]; other site 568703006411 mobile loop; other site 568703006412 roof hairpin; other site 568703006413 CAAX protease self-immunity; Region: Abi; pfam02517 568703006414 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703006415 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006416 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006417 Walker A/P-loop; other site 568703006418 ATP binding site [chemical binding]; other site 568703006419 Q-loop/lid; other site 568703006420 ABC transporter signature motif; other site 568703006421 Walker B; other site 568703006422 D-loop; other site 568703006423 H-loop/switch region; other site 568703006424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006425 DNA-binding site [nucleotide binding]; DNA binding site 568703006426 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703006427 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703006428 CoA binding domain; Region: CoA_binding; pfam02629 568703006429 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703006430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006431 Walker A/P-loop; other site 568703006432 ATP binding site [chemical binding]; other site 568703006433 Q-loop/lid; other site 568703006434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703006435 ABC transporter signature motif; other site 568703006436 Walker B; other site 568703006437 D-loop; other site 568703006438 ABC transporter; Region: ABC_tran_2; pfam12848 568703006439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703006440 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703006441 active site 568703006442 P-loop; other site 568703006443 phosphorylation site [posttranslational modification] 568703006444 UGMP family protein; Validated; Region: PRK09604 568703006445 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568703006446 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 568703006447 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568703006448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703006449 Coenzyme A binding pocket [chemical binding]; other site 568703006450 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568703006451 Glycoprotease family; Region: Peptidase_M22; pfam00814 568703006452 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703006453 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568703006454 active site 568703006455 homotetramer interface [polypeptide binding]; other site 568703006456 homodimer interface [polypeptide binding]; other site 568703006457 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 568703006458 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568703006459 active site 568703006460 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568703006461 active site 2 [active] 568703006462 active site 1 [active] 568703006463 Predicted methyltransferases [General function prediction only]; Region: COG0313 568703006464 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568703006465 putative SAM binding site [chemical binding]; other site 568703006466 putative homodimer interface [polypeptide binding]; other site 568703006467 Protein of unknown function (DUF972); Region: DUF972; pfam06156 568703006468 DNA polymerase III subunit delta'; Validated; Region: PRK08058 568703006469 DNA polymerase III subunit delta'; Validated; Region: PRK08485 568703006470 Protein of unknown function (DUF970); Region: DUF970; pfam06153 568703006471 thymidylate kinase; Validated; Region: tmk; PRK00698 568703006472 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568703006473 TMP-binding site; other site 568703006474 ATP-binding site [chemical binding]; other site 568703006475 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 568703006476 recombination protein RecR; Reviewed; Region: recR; PRK00076 568703006477 RecR protein; Region: RecR; pfam02132 568703006478 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568703006479 putative active site [active] 568703006480 putative metal-binding site [ion binding]; other site 568703006481 tetramer interface [polypeptide binding]; other site 568703006482 hypothetical protein; Validated; Region: PRK00153 568703006483 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 568703006484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703006485 Walker A motif; other site 568703006486 ATP binding site [chemical binding]; other site 568703006487 Walker B motif; other site 568703006488 arginine finger; other site 568703006489 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568703006490 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703006491 nucleoside/Zn binding site; other site 568703006492 dimer interface [polypeptide binding]; other site 568703006493 catalytic motif [active] 568703006494 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568703006495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006496 S-adenosylmethionine binding site [chemical binding]; other site 568703006497 Predicted integral membrane protein [Function unknown]; Region: COG0392 568703006498 Uncharacterized conserved protein [Function unknown]; Region: COG2898 568703006499 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 568703006500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703006501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703006502 DNA binding site [nucleotide binding] 568703006503 domain linker motif; other site 568703006504 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 568703006505 putative dimerization interface [polypeptide binding]; other site 568703006506 putative ligand binding site [chemical binding]; other site 568703006507 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006508 putative active site [active] 568703006509 catalytic triad [active] 568703006510 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006511 putative active site [active] 568703006512 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703006513 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703006514 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568703006515 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568703006516 core dimer interface [polypeptide binding]; other site 568703006517 peripheral dimer interface [polypeptide binding]; other site 568703006518 L10 interface [polypeptide binding]; other site 568703006519 L11 interface [polypeptide binding]; other site 568703006520 putative EF-Tu interaction site [polypeptide binding]; other site 568703006521 putative EF-G interaction site [polypeptide binding]; other site 568703006522 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568703006523 23S rRNA interface [nucleotide binding]; other site 568703006524 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568703006525 drug efflux system protein MdtG; Provisional; Region: PRK09874 568703006526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006527 putative substrate translocation pore; other site 568703006528 benzoate transport; Region: 2A0115; TIGR00895 568703006529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006530 putative substrate translocation pore; other site 568703006531 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 568703006532 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006533 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703006534 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703006535 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006536 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703006537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703006538 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568703006539 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 568703006540 NAD(P) binding site [chemical binding]; other site 568703006541 catalytic residues [active] 568703006542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703006543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703006544 Coenzyme A binding pocket [chemical binding]; other site 568703006545 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568703006546 mRNA/rRNA interface [nucleotide binding]; other site 568703006547 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568703006548 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568703006549 23S rRNA interface [nucleotide binding]; other site 568703006550 L7/L12 interface [polypeptide binding]; other site 568703006551 putative thiostrepton binding site; other site 568703006552 L25 interface [polypeptide binding]; other site 568703006553 magnesium-transporting ATPase; Provisional; Region: PRK15122 568703006554 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703006555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006556 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703006557 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703006558 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006559 amidase; Provisional; Region: PRK06529 568703006560 Amidase; Region: Amidase; cl11426 568703006561 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 568703006562 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 568703006563 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568703006564 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 568703006565 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703006566 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568703006567 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568703006568 putative homodimer interface [polypeptide binding]; other site 568703006569 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568703006570 heterodimer interface [polypeptide binding]; other site 568703006571 homodimer interface [polypeptide binding]; other site 568703006572 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 568703006573 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 568703006574 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 568703006575 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006576 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 568703006577 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006578 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703006579 ApbE family; Region: ApbE; pfam02424 568703006580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 568703006581 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 568703006582 Probable transposase; Region: OrfB_IS605; pfam01385 568703006583 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 568703006584 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 568703006585 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 568703006586 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703006587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703006588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703006589 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703006590 trimer interface [polypeptide binding]; other site 568703006591 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 568703006592 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703006593 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703006594 substrate binding pocket [chemical binding]; other site 568703006595 chain length determination region; other site 568703006596 substrate-Mg2+ binding site; other site 568703006597 catalytic residues [active] 568703006598 aspartate-rich region 1; other site 568703006599 active site lid residues [active] 568703006600 aspartate-rich region 2; other site 568703006601 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703006602 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 568703006603 active site 568703006604 metal binding site [ion binding]; metal-binding site 568703006605 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006606 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703006607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006608 Walker A/P-loop; other site 568703006609 ATP binding site [chemical binding]; other site 568703006610 Q-loop/lid; other site 568703006611 ABC transporter signature motif; other site 568703006612 Walker B; other site 568703006613 D-loop; other site 568703006614 H-loop/switch region; other site 568703006615 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703006616 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703006617 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568703006618 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 568703006619 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 568703006620 YacP-like NYN domain; Region: NYN_YacP; pfam05991 568703006621 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 568703006622 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 568703006623 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568703006624 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 568703006625 active site 568703006626 metal binding site [ion binding]; metal-binding site 568703006627 dimerization interface [polypeptide binding]; other site 568703006628 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568703006629 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006630 active site 568703006631 HIGH motif; other site 568703006632 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006633 KMSKS motif; other site 568703006634 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568703006635 tRNA binding surface [nucleotide binding]; other site 568703006636 anticodon binding site; other site 568703006637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006638 non-specific DNA binding site [nucleotide binding]; other site 568703006639 salt bridge; other site 568703006640 sequence-specific DNA binding site [nucleotide binding]; other site 568703006641 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006642 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 568703006643 FAD binding domain; Region: FAD_binding_4; pfam01565 568703006644 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568703006645 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006646 active site 568703006647 HIGH motif; other site 568703006648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006649 active site 568703006650 KMSKS motif; other site 568703006651 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 568703006652 Predicted membrane protein [General function prediction only]; Region: COG4194 568703006653 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703006654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006655 DNA-binding site [nucleotide binding]; DNA binding site 568703006656 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006658 Walker A/P-loop; other site 568703006659 ATP binding site [chemical binding]; other site 568703006660 ABC transporter; Region: ABC_tran; pfam00005 568703006661 Q-loop/lid; other site 568703006662 ABC transporter signature motif; other site 568703006663 Walker B; other site 568703006664 D-loop; other site 568703006665 H-loop/switch region; other site 568703006666 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703006667 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006668 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006669 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006670 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006671 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006672 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 568703006673 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 568703006674 putative active site [active] 568703006675 DNA repair protein RadA; Provisional; Region: PRK11823 568703006676 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 568703006677 Walker A motif/ATP binding site; other site 568703006678 ATP binding site [chemical binding]; other site 568703006679 Walker B motif; other site 568703006680 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568703006681 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568703006682 trimer interface [polypeptide binding]; other site 568703006683 active site 568703006684 Predicted acetyltransferase [General function prediction only]; Region: COG2388 568703006685 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 568703006686 trimer interface [polypeptide binding]; other site 568703006687 active site 568703006688 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 568703006689 trimer interface [polypeptide binding]; other site 568703006690 active site 568703006691 G bulge; other site 568703006692 Domain of unknown function (DUF373); Region: DUF373; cl12079 568703006693 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 568703006694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006696 Walker A/P-loop; other site 568703006697 ATP binding site [chemical binding]; other site 568703006698 Q-loop/lid; other site 568703006699 ABC transporter signature motif; other site 568703006700 Walker B; other site 568703006701 D-loop; other site 568703006702 H-loop/switch region; other site 568703006703 K+ potassium transporter; Region: K_trans; pfam02705 568703006704 pyruvate phosphate dikinase; Provisional; Region: PRK09279 568703006705 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568703006706 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568703006707 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568703006708 HTH domain; Region: HTH_11; pfam08279 568703006709 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703006710 FOG: CBS domain [General function prediction only]; Region: COG0517 568703006711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006712 catalytic core [active] 568703006713 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006714 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 568703006715 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 568703006716 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 568703006717 teramer interface [polypeptide binding]; other site 568703006718 active site 568703006719 FMN binding site [chemical binding]; other site 568703006720 catalytic residues [active] 568703006721 CsbD-like; Region: CsbD; pfam05532 568703006722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006723 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006724 putative substrate translocation pore; other site 568703006725 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568703006726 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568703006727 putative catalytic cysteine [active] 568703006728 gamma-glutamyl kinase; Provisional; Region: PRK05429 568703006729 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568703006730 nucleotide binding site [chemical binding]; other site 568703006731 homotetrameric interface [polypeptide binding]; other site 568703006732 putative phosphate binding site [ion binding]; other site 568703006733 putative allosteric binding site; other site 568703006734 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703006735 active site 568703006736 catalytic site [active] 568703006737 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 568703006738 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006739 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006740 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006741 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703006742 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703006743 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 568703006744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703006745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006746 non-specific DNA binding site [nucleotide binding]; other site 568703006747 salt bridge; other site 568703006748 sequence-specific DNA binding site [nucleotide binding]; other site 568703006749 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703006750 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703006751 hypothetical protein; Validated; Region: PRK07668 568703006752 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006753 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703006754 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006755 active site 568703006756 catalytic tetrad [active] 568703006757 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703006758 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703006759 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703006760 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 568703006761 HlyD family secretion protein; Region: HlyD_3; pfam13437 568703006762 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 568703006763 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 568703006764 putative active site [active] 568703006765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006767 Walker A/P-loop; other site 568703006768 ATP binding site [chemical binding]; other site 568703006769 Q-loop/lid; other site 568703006770 ABC transporter signature motif; other site 568703006771 Walker B; other site 568703006772 D-loop; other site 568703006773 H-loop/switch region; other site 568703006774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703006775 ATP binding site [chemical binding]; other site 568703006776 Mg2+ binding site [ion binding]; other site 568703006777 G-X-G motif; other site 568703006778 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703006779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 568703006780 phosphorylation site [posttranslational modification] 568703006781 intermolecular recognition site; other site 568703006782 LytTr DNA-binding domain; Region: LytTR; pfam04397 568703006783 CAAX protease self-immunity; Region: Abi; pfam02517 568703006784 Rrf2 family protein; Region: rrf2_super; TIGR00738 568703006785 Transcriptional regulator; Region: Rrf2; pfam02082 568703006786 Transcriptional regulator; Region: Rrf2; cl17282 568703006787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006788 putative substrate translocation pore; other site 568703006789 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703006791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006792 active site 568703006793 catalytic tetrad [active] 568703006794 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 568703006795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006796 NAD(P) binding site [chemical binding]; other site 568703006797 active site 568703006798 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 568703006799 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568703006800 putative active site [active] 568703006801 putative FMN binding site [chemical binding]; other site 568703006802 putative substrate binding site [chemical binding]; other site 568703006803 putative catalytic residue [active] 568703006804 Short C-terminal domain; Region: SHOCT; pfam09851 568703006805 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568703006806 Class II fumarases; Region: Fumarase_classII; cd01362 568703006807 active site 568703006808 tetramer interface [polypeptide binding]; other site 568703006809 manganese transport protein MntH; Reviewed; Region: PRK00701 568703006810 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568703006811 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703006812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703006813 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006814 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703006815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703006816 motif II; other site 568703006817 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006819 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703006820 putative substrate translocation pore; other site 568703006821 multicopper oxidase; Provisional; Region: PRK10965 568703006822 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568703006823 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568703006824 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006825 Cation efflux family; Region: Cation_efflux; cl00316 568703006826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006827 dimerization interface [polypeptide binding]; other site 568703006828 putative DNA binding site [nucleotide binding]; other site 568703006829 putative Zn2+ binding site [ion binding]; other site 568703006830 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 568703006831 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568703006832 metal binding site [ion binding]; metal-binding site 568703006833 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568703006834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568703006835 ABC-ATPase subunit interface; other site 568703006836 dimer interface [polypeptide binding]; other site 568703006837 putative PBP binding regions; other site 568703006838 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703006839 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568703006840 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568703006841 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 568703006842 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006843 intersubunit interface [polypeptide binding]; other site 568703006844 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 568703006845 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703006846 putative NAD(P) binding site [chemical binding]; other site 568703006847 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 568703006848 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006849 metal binding site [ion binding]; metal-binding site 568703006850 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 568703006851 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568703006852 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703006853 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 568703006854 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 568703006855 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703006856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703006857 substrate binding pocket [chemical binding]; other site 568703006858 membrane-bound complex binding site; other site 568703006859 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568703006860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568703006861 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 568703006862 acyl-activating enzyme (AAE) consensus motif; other site 568703006863 acyl-activating enzyme (AAE) consensus motif; other site 568703006864 putative AMP binding site [chemical binding]; other site 568703006865 putative active site [active] 568703006866 putative CoA binding site [chemical binding]; other site 568703006867 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703006868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006869 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 568703006870 Walker A/P-loop; other site 568703006871 ATP binding site [chemical binding]; other site 568703006872 Q-loop/lid; other site 568703006873 ABC transporter signature motif; other site 568703006874 Walker B; other site 568703006875 D-loop; other site 568703006876 H-loop/switch region; other site 568703006877 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703006878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703006879 putative PBP binding loops; other site 568703006880 dimer interface [polypeptide binding]; other site 568703006881 ABC-ATPase subunit interface; other site 568703006882 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 568703006883 B3/4 domain; Region: B3_4; pfam03483 568703006884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006886 Walker A/P-loop; other site 568703006887 ATP binding site [chemical binding]; other site 568703006888 Q-loop/lid; other site 568703006889 ABC transporter signature motif; other site 568703006890 Walker B; other site 568703006891 D-loop; other site 568703006892 H-loop/switch region; other site 568703006893 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006895 Walker A/P-loop; other site 568703006896 ATP binding site [chemical binding]; other site 568703006897 Q-loop/lid; other site 568703006898 ABC transporter signature motif; other site 568703006899 Walker B; other site 568703006900 D-loop; other site 568703006901 H-loop/switch region; other site 568703006902 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006904 putative substrate translocation pore; other site 568703006905 putative transposase OrfB; Reviewed; Region: PHA02517 568703006906 HTH-like domain; Region: HTH_21; pfam13276 568703006907 Integrase core domain; Region: rve; pfam00665 568703006908 Integrase core domain; Region: rve_2; pfam13333 568703006909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703006910 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703006911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703006912 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703006913 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568703006914 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568703006915 23S rRNA interface [nucleotide binding]; other site 568703006916 L3 interface [polypeptide binding]; other site 568703006917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703006918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703006919 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703006920 FtsX-like permease family; Region: FtsX; pfam02687 568703006921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703006922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703006923 Walker A/P-loop; other site 568703006924 ATP binding site [chemical binding]; other site 568703006925 Q-loop/lid; other site 568703006926 ABC transporter signature motif; other site 568703006927 Walker B; other site 568703006928 D-loop; other site 568703006929 H-loop/switch region; other site 568703006930 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 568703006931 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703006932 DNA binding residues [nucleotide binding] 568703006933 dimer interface [polypeptide binding]; other site 568703006934 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 568703006935 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568703006936 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568703006937 dimerization interface 3.5A [polypeptide binding]; other site 568703006938 active site 568703006939 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 568703006940 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 568703006941 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006942 Walker A/P-loop; other site 568703006943 ATP binding site [chemical binding]; other site 568703006944 Q-loop/lid; other site 568703006945 ABC transporter signature motif; other site 568703006946 Walker B; other site 568703006947 D-loop; other site 568703006948 H-loop/switch region; other site 568703006949 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 568703006950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006951 Walker A/P-loop; other site 568703006952 ATP binding site [chemical binding]; other site 568703006953 Q-loop/lid; other site 568703006954 ABC transporter signature motif; other site 568703006955 Walker B; other site 568703006956 D-loop; other site 568703006957 H-loop/switch region; other site 568703006958 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568703006959 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568703006960 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568703006961 alphaNTD homodimer interface [polypeptide binding]; other site 568703006962 alphaNTD - beta interaction site [polypeptide binding]; other site 568703006963 alphaNTD - beta' interaction site [polypeptide binding]; other site 568703006964 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568703006965 30S ribosomal protein S11; Validated; Region: PRK05309 568703006966 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 568703006967 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568703006968 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 568703006969 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568703006970 rRNA binding site [nucleotide binding]; other site 568703006971 predicted 30S ribosome binding site; other site 568703006972 adenylate kinase; Reviewed; Region: adk; PRK00279 568703006973 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568703006974 AMP-binding site [chemical binding]; other site 568703006975 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568703006976 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568703006977 SecY translocase; Region: SecY; pfam00344 568703006978 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568703006979 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568703006980 23S rRNA binding site [nucleotide binding]; other site 568703006981 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568703006982 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568703006983 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568703006984 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568703006985 5S rRNA interface [nucleotide binding]; other site 568703006986 L27 interface [polypeptide binding]; other site 568703006987 23S rRNA interface [nucleotide binding]; other site 568703006988 L5 interface [polypeptide binding]; other site 568703006989 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568703006990 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006991 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006992 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568703006993 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 568703006994 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568703006995 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568703006996 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568703006997 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568703006998 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568703006999 RNA binding site [nucleotide binding]; other site 568703007000 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568703007001 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568703007002 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 568703007003 23S rRNA interface [nucleotide binding]; other site 568703007004 putative translocon interaction site; other site 568703007005 signal recognition particle (SRP54) interaction site; other site 568703007006 L23 interface [polypeptide binding]; other site 568703007007 trigger factor interaction site; other site 568703007008 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568703007009 23S rRNA interface [nucleotide binding]; other site 568703007010 5S rRNA interface [nucleotide binding]; other site 568703007011 putative antibiotic binding site [chemical binding]; other site 568703007012 L25 interface [polypeptide binding]; other site 568703007013 L27 interface [polypeptide binding]; other site 568703007014 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568703007015 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568703007016 G-X-X-G motif; other site 568703007017 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568703007018 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568703007019 putative translocon binding site; other site 568703007020 protein-rRNA interface [nucleotide binding]; other site 568703007021 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568703007022 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568703007023 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568703007024 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568703007025 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568703007026 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568703007027 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 568703007028 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568703007029 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 568703007030 peroxiredoxin; Region: AhpC; TIGR03137 568703007031 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568703007032 dimer interface [polypeptide binding]; other site 568703007033 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568703007034 catalytic triad [active] 568703007035 peroxidatic and resolving cysteines [active] 568703007036 Predicted transcriptional regulator [Transcription]; Region: COG2378 568703007037 WYL domain; Region: WYL; pfam13280 568703007038 elongation factor G; Reviewed; Region: PRK12739 568703007039 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568703007040 G1 box; other site 568703007041 putative GEF interaction site [polypeptide binding]; other site 568703007042 GTP/Mg2+ binding site [chemical binding]; other site 568703007043 Switch I region; other site 568703007044 G2 box; other site 568703007045 G3 box; other site 568703007046 Switch II region; other site 568703007047 G4 box; other site 568703007048 G5 box; other site 568703007049 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568703007050 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568703007051 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568703007052 30S ribosomal protein S7; Validated; Region: PRK05302 568703007053 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568703007054 S17 interaction site [polypeptide binding]; other site 568703007055 S8 interaction site; other site 568703007056 16S rRNA interaction site [nucleotide binding]; other site 568703007057 streptomycin interaction site [chemical binding]; other site 568703007058 23S rRNA interaction site [nucleotide binding]; other site 568703007059 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568703007060 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 568703007061 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568703007062 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568703007063 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568703007064 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568703007065 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568703007066 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568703007067 DNA binding site [nucleotide binding] 568703007068 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568703007069 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568703007070 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568703007071 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568703007072 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568703007073 RPB1 interaction site [polypeptide binding]; other site 568703007074 RPB10 interaction site [polypeptide binding]; other site 568703007075 RPB11 interaction site [polypeptide binding]; other site 568703007076 RPB3 interaction site [polypeptide binding]; other site 568703007077 RPB12 interaction site [polypeptide binding]; other site 568703007078 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 568703007079 Clp amino terminal domain; Region: Clp_N; pfam02861 568703007080 Clp amino terminal domain; Region: Clp_N; pfam02861 568703007081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007082 Walker A motif; other site 568703007083 ATP binding site [chemical binding]; other site 568703007084 Walker B motif; other site 568703007085 arginine finger; other site 568703007086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007087 Walker A motif; other site 568703007088 ATP binding site [chemical binding]; other site 568703007089 Walker B motif; other site 568703007090 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703007091 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 568703007092 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 568703007093 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 568703007094 dimer interface [polypeptide binding]; other site 568703007095 putative anticodon binding site; other site 568703007096 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568703007097 motif 1; other site 568703007098 active site 568703007099 motif 2; other site 568703007100 motif 3; other site 568703007101 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 568703007102 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568703007103 FMN binding site [chemical binding]; other site 568703007104 active site 568703007105 catalytic residues [active] 568703007106 substrate binding site [chemical binding]; other site 568703007107 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568703007108 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568703007109 dimerization interface [polypeptide binding]; other site 568703007110 domain crossover interface; other site 568703007111 redox-dependent activation switch; other site 568703007112 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 568703007113 FtsH Extracellular; Region: FtsH_ext; pfam06480 568703007114 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 568703007115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007116 Walker A motif; other site 568703007117 ATP binding site [chemical binding]; other site 568703007118 Walker B motif; other site 568703007119 arginine finger; other site 568703007120 Peptidase family M41; Region: Peptidase_M41; pfam01434 568703007121 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 568703007122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007123 active site 568703007124 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 568703007125 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568703007126 Ligand Binding Site [chemical binding]; other site 568703007127 TilS substrate C-terminal domain; Region: TilS_C; smart00977 568703007128 hypothetical protein; Provisional; Region: PRK08582 568703007129 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 568703007130 RNA binding site [nucleotide binding]; other site 568703007131 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 568703007132 Septum formation initiator; Region: DivIC; pfam04977 568703007133 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703007134 RNA binding surface [nucleotide binding]; other site 568703007135 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703007136 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 568703007137 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 568703007138 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568703007139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703007140 ATP binding site [chemical binding]; other site 568703007141 putative Mg++ binding site [ion binding]; other site 568703007142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703007143 nucleotide binding region [chemical binding]; other site 568703007144 ATP-binding site [chemical binding]; other site 568703007145 TRCF domain; Region: TRCF; pfam03461 568703007146 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568703007147 putative active site [active] 568703007148 catalytic residue [active] 568703007149 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703007150 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703007151 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007152 NAD binding site [chemical binding]; other site 568703007153 dimer interface [polypeptide binding]; other site 568703007154 substrate binding site [chemical binding]; other site 568703007155 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703007156 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703007157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703007158 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703007159 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703007160 Predicted membrane protein [Function unknown]; Region: COG1511 568703007161 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703007162 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703007163 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703007164 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703007165 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 568703007166 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703007167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568703007168 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 568703007169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568703007170 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568703007171 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 568703007172 active site 568703007173 dimer interface [polypeptide binding]; other site 568703007174 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568703007175 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568703007176 active site 568703007177 FMN binding site [chemical binding]; other site 568703007178 substrate binding site [chemical binding]; other site 568703007179 3Fe-4S cluster binding site [ion binding]; other site 568703007180 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568703007181 domain interface; other site 568703007182 QueT transporter; Region: QueT; pfam06177 568703007183 PemK-like protein; Region: PemK; pfam02452 568703007184 hypothetical protein; Region: PHA01623 568703007185 alanine racemase; Reviewed; Region: alr; PRK00053 568703007186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 568703007187 active site 568703007188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703007189 dimer interface [polypeptide binding]; other site 568703007190 substrate binding site [chemical binding]; other site 568703007191 catalytic residues [active] 568703007192 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568703007193 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568703007194 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703007195 ATP binding site [chemical binding]; other site 568703007196 Mg++ binding site [ion binding]; other site 568703007197 motif III; other site 568703007198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703007199 nucleotide binding region [chemical binding]; other site 568703007200 ATP-binding site [chemical binding]; other site 568703007201 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 568703007202 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703007203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703007204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703007205 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 568703007206 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 568703007207 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568703007208 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568703007209 hinge; other site 568703007210 active site 568703007211 CTP synthetase; Validated; Region: pyrG; PRK05380 568703007212 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568703007213 Catalytic site [active] 568703007214 active site 568703007215 UTP binding site [chemical binding]; other site 568703007216 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568703007217 active site 568703007218 putative oxyanion hole; other site 568703007219 catalytic triad [active] 568703007220 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703007221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703007222 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703007223 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 568703007224 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 568703007225 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568703007226 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 568703007227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703007228 Zn2+ binding site [ion binding]; other site 568703007229 Mg2+ binding site [ion binding]; other site 568703007230 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 568703007231 nudix motif; other site 568703007232 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568703007233 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568703007234 putative active site [active] 568703007235 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 568703007236 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 568703007237 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 568703007238 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568703007239 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568703007240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007241 active site 568703007242 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 568703007243 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568703007244 Substrate binding site; other site 568703007245 Mg++ binding site; other site 568703007246 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568703007247 active site 568703007248 substrate binding site [chemical binding]; other site 568703007249 CoA binding site [chemical binding]; other site 568703007250 VanZ like family; Region: VanZ; pfam04892 568703007251 RDD family; Region: RDD; pfam06271 568703007252 pur operon repressor; Provisional; Region: PRK09213 568703007253 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 568703007254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007255 active site 568703007256 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 568703007257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007258 Walker A/P-loop; other site 568703007259 ATP binding site [chemical binding]; other site 568703007260 Q-loop/lid; other site 568703007261 ABC transporter signature motif; other site 568703007262 Walker B; other site 568703007263 D-loop; other site 568703007264 H-loop/switch region; other site 568703007265 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 568703007266 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 568703007267 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703007268 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 568703007269 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703007270 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703007271 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 568703007272 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568703007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703007274 S-adenosylmethionine binding site [chemical binding]; other site 568703007275 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 568703007276 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 568703007277 putative active site [active] 568703007278 putative metal binding site [ion binding]; other site 568703007279 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 568703007280 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568703007281 active site 568703007282 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007283 active site 568703007284 phosphorylation site [posttranslational modification] 568703007285 Class I aldolases; Region: Aldolase_Class_I; cl17187 568703007286 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703007287 active site 568703007288 catalytic residues [active] 568703007289 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703007290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703007291 active site 568703007292 phosphorylation site [posttranslational modification] 568703007293 intermolecular recognition site; other site 568703007294 dimerization interface [polypeptide binding]; other site 568703007295 LytTr DNA-binding domain; Region: LytTR; pfam04397 568703007296 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 568703007297 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 568703007298 ATP binding site [chemical binding]; other site 568703007299 Mg2+ binding site [ion binding]; other site 568703007300 G-X-G motif; other site 568703007301 Transmembrane protein 231; Region: TM231; pfam10149 568703007302 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703007303 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703007304 Walker A/P-loop; other site 568703007305 ATP binding site [chemical binding]; other site 568703007306 Q-loop/lid; other site 568703007307 ABC transporter signature motif; other site 568703007308 Walker B; other site 568703007309 D-loop; other site 568703007310 H-loop/switch region; other site 568703007311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703007312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007313 Walker A/P-loop; other site 568703007314 ATP binding site [chemical binding]; other site 568703007315 Q-loop/lid; other site 568703007316 ABC transporter signature motif; other site 568703007317 Walker B; other site 568703007318 D-loop; other site 568703007319 H-loop/switch region; other site 568703007320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703007321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007322 non-specific DNA binding site [nucleotide binding]; other site 568703007323 salt bridge; other site 568703007324 sequence-specific DNA binding site [nucleotide binding]; other site 568703007325 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 568703007326 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568703007327 active site 568703007328 HIGH motif; other site 568703007329 KMSKS motif; other site 568703007330 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568703007331 tRNA binding surface [nucleotide binding]; other site 568703007332 anticodon binding site; other site 568703007333 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 568703007334 dimer interface [polypeptide binding]; other site 568703007335 putative tRNA-binding site [nucleotide binding]; other site 568703007336 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703007337 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703007338 Protein of unknown function DUF72; Region: DUF72; pfam01904 568703007339 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 568703007340 putative active site [active] 568703007341 nucleotide binding site [chemical binding]; other site 568703007342 nudix motif; other site 568703007343 putative metal binding site [ion binding]; other site 568703007344 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 568703007345 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 568703007346 LDH/MDH dimer interface [polypeptide binding]; other site 568703007347 NAD(P) binding site [chemical binding]; other site 568703007348 substrate binding site [chemical binding]; other site 568703007349 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703007350 NAD-dependent deacetylase; Provisional; Region: PRK00481 568703007351 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703007352 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568703007353 substrate binding site [chemical binding]; other site 568703007354 Predicted secreted protein [Function unknown]; Region: COG4086 568703007355 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 568703007356 exopolyphosphatase; Region: exo_poly_only; TIGR03706 568703007357 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703007358 polyphosphate kinase; Provisional; Region: PRK05443 568703007359 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568703007360 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568703007361 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 568703007362 putative domain interface [polypeptide binding]; other site 568703007363 putative active site [active] 568703007364 catalytic site [active] 568703007365 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 568703007366 putative domain interface [polypeptide binding]; other site 568703007367 putative active site [active] 568703007368 catalytic site [active] 568703007369 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703007370 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007371 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007372 active site 568703007373 catalytic tetrad [active] 568703007374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568703007375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703007376 S-adenosylmethionine binding site [chemical binding]; other site 568703007377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703007378 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703007379 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 568703007380 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 568703007381 Repair protein; Region: Repair_PSII; pfam04536 568703007382 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 568703007383 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568703007384 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568703007385 active site 568703007386 HIGH motif; other site 568703007387 dimer interface [polypeptide binding]; other site 568703007388 KMSKS motif; other site 568703007389 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 568703007390 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703007391 Walker A/P-loop; other site 568703007392 ATP binding site [chemical binding]; other site 568703007393 Q-loop/lid; other site 568703007394 ABC transporter signature motif; other site 568703007395 Walker B; other site 568703007396 D-loop; other site 568703007397 H-loop/switch region; other site 568703007398 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 568703007399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703007400 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703007401 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568703007402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007403 Walker A/P-loop; other site 568703007404 ATP binding site [chemical binding]; other site 568703007405 Q-loop/lid; other site 568703007406 ABC transporter signature motif; other site 568703007407 Walker B; other site 568703007408 D-loop; other site 568703007409 H-loop/switch region; other site 568703007410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007411 dimer interface [polypeptide binding]; other site 568703007412 conserved gate region; other site 568703007413 ABC-ATPase subunit interface; other site 568703007414 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 568703007415 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703007416 Part of AAA domain; Region: AAA_19; pfam13245 568703007417 Family description; Region: UvrD_C_2; pfam13538 568703007418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007420 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568703007421 dimerization interface [polypeptide binding]; other site 568703007422 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 568703007423 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 568703007424 gating phenylalanine in ion channel; other site 568703007425 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703007426 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568703007427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007428 Walker A/P-loop; other site 568703007429 ATP binding site [chemical binding]; other site 568703007430 Q-loop/lid; other site 568703007431 ABC transporter signature motif; other site 568703007432 Walker B; other site 568703007433 D-loop; other site 568703007434 H-loop/switch region; other site 568703007435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703007436 putative DNA binding site [nucleotide binding]; other site 568703007437 dimerization interface [polypeptide binding]; other site 568703007438 putative Zn2+ binding site [ion binding]; other site 568703007439 CAAX protease self-immunity; Region: Abi; pfam02517 568703007440 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703007441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703007442 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703007443 Walker A/P-loop; other site 568703007444 ATP binding site [chemical binding]; other site 568703007445 Q-loop/lid; other site 568703007446 ABC transporter signature motif; other site 568703007447 Walker B; other site 568703007448 D-loop; other site 568703007449 H-loop/switch region; other site 568703007450 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 568703007451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 568703007452 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703007453 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568703007454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007455 Walker A/P-loop; other site 568703007456 ATP binding site [chemical binding]; other site 568703007457 Q-loop/lid; other site 568703007458 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568703007459 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 568703007460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007461 ABC transporter signature motif; other site 568703007462 Walker B; other site 568703007463 D-loop; other site 568703007464 H-loop/switch region; other site 568703007465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007466 Walker A/P-loop; other site 568703007467 ATP binding site [chemical binding]; other site 568703007468 Q-loop/lid; other site 568703007469 ABC transporter signature motif; other site 568703007470 Walker B; other site 568703007471 D-loop; other site 568703007472 H-loop/switch region; other site 568703007473 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007474 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007475 active site 568703007476 catalytic tetrad [active] 568703007477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 568703007478 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007479 active site 568703007480 motif I; other site 568703007481 motif II; other site 568703007482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007483 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 568703007484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703007485 catalytic core [active] 568703007486 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 568703007487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007488 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007489 active site 568703007490 motif I; other site 568703007491 motif II; other site 568703007492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007493 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568703007494 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703007495 active site 568703007496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703007499 dimerization interface [polypeptide binding]; other site 568703007500 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 568703007501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703007502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703007503 homodimer interface [polypeptide binding]; other site 568703007504 catalytic residue [active] 568703007505 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703007506 recombinase A; Provisional; Region: recA; PRK09354 568703007507 hexamer interface [polypeptide binding]; other site 568703007508 Walker A motif; other site 568703007509 ATP binding site [chemical binding]; other site 568703007510 Walker B motif; other site 568703007511 Protein of unknown function (DUF554); Region: DUF554; pfam04474 568703007512 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 568703007513 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703007514 active site 568703007515 P-loop; other site 568703007516 phosphorylation site [posttranslational modification] 568703007517 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703007518 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007519 active site 568703007520 phosphorylation site [posttranslational modification] 568703007521 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703007522 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703007523 putative substrate binding site [chemical binding]; other site 568703007524 putative ATP binding site [chemical binding]; other site 568703007525 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007526 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007527 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007528 putative active site [active] 568703007529 glycerol kinase; Provisional; Region: glpK; PRK00047 568703007530 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703007531 N- and C-terminal domain interface [polypeptide binding]; other site 568703007532 active site 568703007533 MgATP binding site [chemical binding]; other site 568703007534 catalytic site [active] 568703007535 metal binding site [ion binding]; metal-binding site 568703007536 glycerol binding site [chemical binding]; other site 568703007537 homotetramer interface [polypeptide binding]; other site 568703007538 homodimer interface [polypeptide binding]; other site 568703007539 FBP binding site [chemical binding]; other site 568703007540 protein IIAGlc interface [polypeptide binding]; other site 568703007541 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007543 DNA-binding site [nucleotide binding]; DNA binding site 568703007544 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703007545 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703007546 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703007547 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 568703007548 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703007549 active site 568703007550 active pocket/dimerization site; other site 568703007551 phosphorylation site [posttranslational modification] 568703007552 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703007553 active site 568703007554 phosphorylation site [posttranslational modification] 568703007555 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007556 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007557 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 568703007558 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 568703007559 Flavoprotein; Region: Flavoprotein; pfam02441 568703007560 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703007561 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 568703007562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703007565 dimerization interface [polypeptide binding]; other site 568703007566 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703007567 MarR family; Region: MarR_2; pfam12802 568703007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007570 putative substrate translocation pore; other site 568703007571 galactonate dehydratase; Provisional; Region: PRK14017 568703007572 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 568703007573 metal binding site [ion binding]; metal-binding site 568703007574 substrate binding pocket [chemical binding]; other site 568703007575 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703007576 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007577 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703007578 active site 568703007579 P-loop; other site 568703007580 phosphorylation site [posttranslational modification] 568703007581 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007582 active site 568703007583 phosphorylation site [posttranslational modification] 568703007584 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 568703007585 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703007586 active site 568703007587 intersubunit interface [polypeptide binding]; other site 568703007588 catalytic residue [active] 568703007589 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007590 PRD domain; Region: PRD; pfam00874 568703007591 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007592 active site 568703007593 P-loop; other site 568703007594 phosphorylation site [posttranslational modification] 568703007595 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007596 active site 568703007597 phosphorylation site [posttranslational modification] 568703007598 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703007599 active site 568703007600 methionine cluster; other site 568703007601 phosphorylation site [posttranslational modification] 568703007602 metal binding site [ion binding]; metal-binding site 568703007603 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703007604 active site 568703007605 P-loop; other site 568703007606 phosphorylation site [posttranslational modification] 568703007607 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703007608 beta-galactosidase; Region: BGL; TIGR03356 568703007609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703007610 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007611 nucleotide binding site [chemical binding]; other site 568703007612 Uncharacterized conserved protein [Function unknown]; Region: COG3538 568703007613 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 568703007614 alpha-mannosidase; Provisional; Region: PRK09819 568703007615 Transposase domain (DUF772); Region: DUF772; pfam05598 568703007616 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703007617 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 568703007618 active site 568703007619 metal binding site [ion binding]; metal-binding site 568703007620 catalytic site [active] 568703007621 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703007622 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703007623 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703007624 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007626 DNA-binding site [nucleotide binding]; DNA binding site 568703007627 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703007628 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007629 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703007630 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703007631 hypothetical protein; Provisional; Region: PRK06357 568703007632 active site 568703007633 intersubunit interface [polypeptide binding]; other site 568703007634 Zn2+ binding site [ion binding]; other site 568703007635 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 568703007636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007637 putative substrate translocation pore; other site 568703007638 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703007639 Phage protein; Region: DUF3647; cl10335 568703007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007641 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007642 N- and C-terminal domain interface [polypeptide binding]; other site 568703007643 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007644 active site 568703007645 putative catalytic site [active] 568703007646 metal binding site [ion binding]; metal-binding site 568703007647 ATP binding site [chemical binding]; other site 568703007648 carbohydrate binding site [chemical binding]; other site 568703007649 L-fucose isomerase; Provisional; Region: fucI; PRK10991 568703007650 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 568703007651 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703007652 trimer interface [polypeptide binding]; other site 568703007653 substrate binding site [chemical binding]; other site 568703007654 Mn binding site [ion binding]; other site 568703007655 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 568703007656 intersubunit interface [polypeptide binding]; other site 568703007657 active site 568703007658 Zn2+ binding site [ion binding]; other site 568703007659 L-rhamnose isomerase; Provisional; Region: PRK01076 568703007660 Domain of unknown function (DUF718); Region: DUF718; cl01281 568703007661 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007662 N- and C-terminal domain interface [polypeptide binding]; other site 568703007663 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007664 active site 568703007665 putative catalytic site [active] 568703007666 metal binding site [ion binding]; metal-binding site 568703007667 ATP binding site [chemical binding]; other site 568703007668 carbohydrate binding site [chemical binding]; other site 568703007669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007670 putative substrate translocation pore; other site 568703007671 Cupin domain; Region: Cupin_2; pfam07883 568703007672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703007673 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568703007674 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 568703007675 catalytic Zn binding site [ion binding]; other site 568703007676 NAD binding site [chemical binding]; other site 568703007677 structural Zn binding site [ion binding]; other site 568703007678 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 568703007679 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703007680 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703007681 Ca binding site [ion binding]; other site 568703007682 active site 568703007683 catalytic site [active] 568703007684 putative transposase OrfB; Reviewed; Region: PHA02517 568703007685 HTH-like domain; Region: HTH_21; pfam13276 568703007686 Integrase core domain; Region: rve; pfam00665 568703007687 Integrase core domain; Region: rve_2; pfam13333 568703007688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703007689 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703007690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703007691 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703007692 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568703007693 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007694 active site 568703007695 dimer interface [polypeptide binding]; other site 568703007696 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 568703007697 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 568703007698 NAD binding site [chemical binding]; other site 568703007699 sugar binding site [chemical binding]; other site 568703007700 divalent metal binding site [ion binding]; other site 568703007701 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007702 dimer interface [polypeptide binding]; other site 568703007703 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 568703007704 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703007705 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703007706 active site turn [active] 568703007707 phosphorylation site [posttranslational modification] 568703007708 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007709 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007710 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007711 putative active site [active] 568703007712 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703007713 HPr interaction site; other site 568703007714 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703007715 active site 568703007716 phosphorylation site [posttranslational modification] 568703007717 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 568703007718 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703007719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703007720 catalytic residue [active] 568703007721 dihydroorotase; Provisional; Region: PRK09237 568703007722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703007723 active site 568703007724 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 568703007725 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 568703007726 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 568703007727 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 568703007728 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 568703007729 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007730 HTH domain; Region: HTH_11; pfam08279 568703007731 HTH domain; Region: HTH_11; pfam08279 568703007732 PRD domain; Region: PRD; pfam00874 568703007733 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007734 active site 568703007735 P-loop; other site 568703007736 phosphorylation site [posttranslational modification] 568703007737 Class I aldolases; Region: Aldolase_Class_I; cl17187 568703007738 catalytic residue [active] 568703007739 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 568703007740 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 568703007741 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 568703007742 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 568703007743 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 568703007744 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 568703007745 HTH domain; Region: HTH_11; cl17392 568703007746 HTH domain; Region: HTH_11; pfam08279 568703007747 PRD domain; Region: PRD; pfam00874 568703007748 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007749 active site 568703007750 phosphorylation site [posttranslational modification] 568703007751 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 568703007752 classical (c) SDRs; Region: SDR_c; cd05233 568703007753 NAD(P) binding site [chemical binding]; other site 568703007754 active site 568703007755 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568703007756 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568703007757 intersubunit interface [polypeptide binding]; other site 568703007758 active site 568703007759 Zn2+ binding site [ion binding]; other site 568703007760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007761 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007762 active site 568703007763 motif I; other site 568703007764 motif II; other site 568703007765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007766 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 568703007767 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 568703007768 AP (apurinic/apyrimidinic) site pocket; other site 568703007769 DNA interaction; other site 568703007770 Metal-binding active site; metal-binding site 568703007771 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007772 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703007773 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703007774 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568703007775 active site 568703007776 dimer interface [polypeptide binding]; other site 568703007777 magnesium binding site [ion binding]; other site 568703007778 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703007779 active site 568703007780 P-loop; other site 568703007781 phosphorylation site [posttranslational modification] 568703007782 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 568703007783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007784 active site 568703007785 phosphorylation site [posttranslational modification] 568703007786 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 568703007787 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703007788 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703007789 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703007790 catalytic triad [active] 568703007791 putative active site [active] 568703007792 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703007793 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703007795 nucleotide binding site [chemical binding]; other site 568703007796 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 568703007797 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 568703007798 active site 568703007799 dimer interface [polypeptide binding]; other site 568703007800 catalytic nucleophile [active] 568703007801 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703007802 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 568703007803 active site 568703007804 metal binding site [ion binding]; metal-binding site 568703007805 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007807 DNA-binding site [nucleotide binding]; DNA binding site 568703007808 UTRA domain; Region: UTRA; pfam07702 568703007809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007811 putative substrate translocation pore; other site 568703007812 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703007813 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703007814 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703007815 D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803 568703007816 N- and C-terminal domain interface [polypeptide binding]; other site 568703007817 active site 568703007818 MgATP binding site [chemical binding]; other site 568703007819 catalytic site [active] 568703007820 metal binding site [ion binding]; metal-binding site 568703007821 xylulose binding site [chemical binding]; other site 568703007822 homodimer interface [polypeptide binding]; other site 568703007823 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568703007824 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568703007825 NAD(P) binding site [chemical binding]; other site 568703007826 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007827 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007828 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703007829 active site 568703007830 phosphorylation site [posttranslational modification] 568703007831 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703007832 active pocket/dimerization site; other site 568703007833 active site 568703007834 phosphorylation site [posttranslational modification] 568703007835 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703007836 active site 568703007837 phosphorylation site [posttranslational modification] 568703007838 Transposase domain (DUF772); Region: DUF772; pfam05598 568703007839 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703007840 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703007841 intersubunit interface [polypeptide binding]; other site 568703007842 active site 568703007843 zinc binding site [ion binding]; other site 568703007844 Na+ binding site [ion binding]; other site 568703007845 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 568703007846 putative N- and C-terminal domain interface [polypeptide binding]; other site 568703007847 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703007848 putative active site [active] 568703007849 putative MgATP binding site [chemical binding]; other site 568703007850 catalytic site [active] 568703007851 metal binding site [ion binding]; metal-binding site 568703007852 putative carbohydrate binding site [chemical binding]; other site 568703007853 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703007854 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007855 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703007856 active site 568703007857 P-loop; other site 568703007858 phosphorylation site [posttranslational modification] 568703007859 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007860 active site 568703007861 phosphorylation site [posttranslational modification] 568703007862 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703007863 intersubunit interface [polypeptide binding]; other site 568703007864 active site 568703007865 zinc binding site [ion binding]; other site 568703007866 Na+ binding site [ion binding]; other site 568703007867 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007869 DNA-binding site [nucleotide binding]; DNA binding site 568703007870 UTRA domain; Region: UTRA; pfam07702 568703007871 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 568703007872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007873 Coenzyme A binding pocket [chemical binding]; other site 568703007874 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 568703007875 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 568703007876 nudix motif; other site 568703007877 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 568703007878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703007879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007880 non-specific DNA binding site [nucleotide binding]; other site 568703007881 salt bridge; other site 568703007882 sequence-specific DNA binding site [nucleotide binding]; other site 568703007883 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 568703007884 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 568703007885 active site 568703007886 catalytic site [active] 568703007887 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 568703007888 sugar binding site [chemical binding]; other site 568703007889 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 568703007890 putative dockerin binding interface; other site 568703007891 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 568703007892 nudix motif; other site 568703007893 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 568703007894 Isochorismatase family; Region: Isochorismatase; pfam00857 568703007895 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568703007896 catalytic triad [active] 568703007897 conserved cis-peptide bond; other site 568703007898 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703007899 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 568703007900 active site 568703007901 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703007902 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 568703007903 active site 568703007904 catalytic site [active] 568703007905 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 568703007906 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568703007907 active site 568703007908 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703007909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703007910 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703007911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007912 dimer interface [polypeptide binding]; other site 568703007913 conserved gate region; other site 568703007914 putative PBP binding loops; other site 568703007915 ABC-ATPase subunit interface; other site 568703007916 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 568703007917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007918 dimer interface [polypeptide binding]; other site 568703007919 conserved gate region; other site 568703007920 putative PBP binding loops; other site 568703007921 ABC-ATPase subunit interface; other site 568703007922 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568703007923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007924 Walker A/P-loop; other site 568703007925 ATP binding site [chemical binding]; other site 568703007926 Q-loop/lid; other site 568703007927 ABC transporter signature motif; other site 568703007928 Walker B; other site 568703007929 D-loop; other site 568703007930 H-loop/switch region; other site 568703007931 TOBE domain; Region: TOBE_2; pfam08402 568703007932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007933 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 568703007934 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703007935 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703007936 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703007937 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703007938 putative active site [active] 568703007939 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007940 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007941 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007942 putative active site [active] 568703007943 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703007944 active site 568703007945 phosphorylation site [posttranslational modification] 568703007946 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007947 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007948 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568703007949 putative catalytic site [active] 568703007950 putative metal binding site [ion binding]; other site 568703007951 putative phosphate binding site [ion binding]; other site 568703007952 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703007953 DHH family; Region: DHH; pfam01368 568703007954 DHHA1 domain; Region: DHHA1; pfam02272 568703007955 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007956 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007957 active site 568703007958 catalytic tetrad [active] 568703007959 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703007960 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703007961 DNA binding residues [nucleotide binding] 568703007962 putative dimer interface [polypeptide binding]; other site 568703007963 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 568703007964 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 568703007965 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 568703007966 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 568703007967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703007968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703007969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007970 Coenzyme A binding pocket [chemical binding]; other site 568703007971 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 568703007972 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 568703007973 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 568703007974 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703007975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007976 Coenzyme A binding pocket [chemical binding]; other site 568703007977 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703007978 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 568703007979 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703007980 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 568703007981 transmembrane helices; other site 568703007982 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 568703007983 hypothetical protein; Provisional; Region: PRK06446 568703007984 metal binding site [ion binding]; metal-binding site 568703007985 dimer interface [polypeptide binding]; other site 568703007986 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703007987 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703007988 peptide binding site [polypeptide binding]; other site 568703007989 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 568703007990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703007991 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703007992 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703007993 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703007994 putative dimer interface [polypeptide binding]; other site 568703007995 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 568703007996 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568703007997 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568703007998 protein binding site [polypeptide binding]; other site 568703007999 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 568703008000 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703008001 YycH protein; Region: YycI; pfam09648 568703008002 YycH protein; Region: YycH; pfam07435 568703008003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 568703008004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 568703008005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703008006 dimerization interface [polypeptide binding]; other site 568703008007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568703008008 putative active site [active] 568703008009 heme pocket [chemical binding]; other site 568703008010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703008011 dimer interface [polypeptide binding]; other site 568703008012 phosphorylation site [posttranslational modification] 568703008013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703008014 ATP binding site [chemical binding]; other site 568703008015 Mg2+ binding site [ion binding]; other site 568703008016 G-X-G motif; other site 568703008017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703008018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703008019 active site 568703008020 phosphorylation site [posttranslational modification] 568703008021 intermolecular recognition site; other site 568703008022 dimerization interface [polypeptide binding]; other site 568703008023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703008024 DNA binding site [nucleotide binding] 568703008025 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703008026 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568703008027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008029 substrate binding pocket [chemical binding]; other site 568703008030 membrane-bound complex binding site; other site 568703008031 hinge residues; other site 568703008032 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703008033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008034 dimer interface [polypeptide binding]; other site 568703008035 conserved gate region; other site 568703008036 putative PBP binding loops; other site 568703008037 ABC-ATPase subunit interface; other site 568703008038 argininosuccinate synthase; Provisional; Region: PRK13820 568703008039 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 568703008040 ANP binding site [chemical binding]; other site 568703008041 Substrate Binding Site II [chemical binding]; other site 568703008042 Substrate Binding Site I [chemical binding]; other site 568703008043 argininosuccinate lyase; Provisional; Region: PRK00855 568703008044 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568703008045 active sites [active] 568703008046 tetramer interface [polypeptide binding]; other site 568703008047 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703008048 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703008049 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703008050 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703008051 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703008052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703008053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703008054 DNA-binding site [nucleotide binding]; DNA binding site 568703008055 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703008056 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703008057 active site 568703008058 P-loop; other site 568703008059 phosphorylation site [posttranslational modification] 568703008060 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703008061 active site 568703008062 methionine cluster; other site 568703008063 phosphorylation site [posttranslational modification] 568703008064 metal binding site [ion binding]; metal-binding site 568703008065 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703008066 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703008067 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703008068 nudix motif; other site 568703008069 hypothetical protein; Provisional; Region: PRK06762 568703008070 AAA domain; Region: AAA_33; pfam13671 568703008071 Isochorismatase family; Region: Isochorismatase; pfam00857 568703008072 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568703008073 catalytic triad [active] 568703008074 dimer interface [polypeptide binding]; other site 568703008075 conserved cis-peptide bond; other site 568703008076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703008077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703008078 putative substrate translocation pore; other site 568703008079 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 568703008080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703008081 putative substrate translocation pore; other site 568703008082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703008083 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703008084 active site 568703008085 catalytic tetrad [active] 568703008086 Domain of unknown function (DUF956); Region: DUF956; pfam06115 568703008087 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703008088 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 568703008089 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703008090 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703008091 active pocket/dimerization site; other site 568703008092 active site 568703008093 phosphorylation site [posttranslational modification] 568703008094 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703008095 active site 568703008096 phosphorylation site [posttranslational modification] 568703008097 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703008098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008099 non-specific DNA binding site [nucleotide binding]; other site 568703008100 salt bridge; other site 568703008101 sequence-specific DNA binding site [nucleotide binding]; other site 568703008102 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703008103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008104 non-specific DNA binding site [nucleotide binding]; other site 568703008105 salt bridge; other site 568703008106 sequence-specific DNA binding site [nucleotide binding]; other site 568703008107 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703008108 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 568703008109 active site 568703008110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008112 substrate binding pocket [chemical binding]; other site 568703008113 membrane-bound complex binding site; other site 568703008114 hinge residues; other site 568703008115 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703008116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008117 dimer interface [polypeptide binding]; other site 568703008118 conserved gate region; other site 568703008119 putative PBP binding loops; other site 568703008120 ABC-ATPase subunit interface; other site 568703008121 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703008122 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703008123 Walker A/P-loop; other site 568703008124 ATP binding site [chemical binding]; other site 568703008125 Q-loop/lid; other site 568703008126 ABC transporter signature motif; other site 568703008127 Walker B; other site 568703008128 D-loop; other site 568703008129 H-loop/switch region; other site 568703008130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703008131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703008132 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703008133 Uncharacterized conserved protein [Function unknown]; Region: COG3402 568703008134 Predicted membrane protein [Function unknown]; Region: COG3428 568703008135 Bacterial PH domain; Region: DUF304; pfam03703 568703008136 Bacterial PH domain; Region: DUF304; pfam03703 568703008137 Predicted ATPase [General function prediction only]; Region: COG3910 568703008138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 568703008139 Walker A/P-loop; other site 568703008140 ATP binding site [chemical binding]; other site 568703008141 Q-loop/lid; other site 568703008142 ABC transporter signature motif; other site 568703008143 Walker B; other site 568703008144 D-loop; other site 568703008145 H-loop/switch region; other site 568703008146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 568703008147 Phosphotransferase enzyme family; Region: APH; pfam01636 568703008148 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703008149 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703008150 Walker A/P-loop; other site 568703008151 ATP binding site [chemical binding]; other site 568703008152 Q-loop/lid; other site 568703008153 ABC transporter signature motif; other site 568703008154 Walker B; other site 568703008155 D-loop; other site 568703008156 H-loop/switch region; other site 568703008157 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008159 substrate binding pocket [chemical binding]; other site 568703008160 membrane-bound complex binding site; other site 568703008161 hinge residues; other site 568703008162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008163 dimer interface [polypeptide binding]; other site 568703008164 conserved gate region; other site 568703008165 putative PBP binding loops; other site 568703008166 ABC-ATPase subunit interface; other site 568703008167 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008169 substrate binding pocket [chemical binding]; other site 568703008170 membrane-bound complex binding site; other site 568703008171 hinge residues; other site 568703008172 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703008173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008174 dimer interface [polypeptide binding]; other site 568703008175 conserved gate region; other site 568703008176 putative PBP binding loops; other site 568703008177 ABC-ATPase subunit interface; other site 568703008178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703008179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703008180 Integral membrane protein DUF95; Region: DUF95; pfam01944 568703008181 MoxR-like ATPases [General function prediction only]; Region: COG0714 568703008182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703008183 Walker A motif; other site 568703008184 ATP binding site [chemical binding]; other site 568703008185 Walker B motif; other site 568703008186 arginine finger; other site 568703008187 Protein of unknown function DUF58; Region: DUF58; pfam01882 568703008188 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 568703008189 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 568703008190 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 568703008191 putative ADP-binding pocket [chemical binding]; other site 568703008192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703008193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703008194 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703008196 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008197 putative transposase OrfB; Reviewed; Region: PHA02517 568703008198 HTH-like domain; Region: HTH_21; pfam13276 568703008199 Integrase core domain; Region: rve; pfam00665 568703008200 Integrase core domain; Region: rve_2; pfam13333 568703008201 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 568703008202 Aspartase; Region: Aspartase; cd01357 568703008203 active sites [active] 568703008204 tetramer interface [polypeptide binding]; other site 568703008205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 568703008206 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 568703008207 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 568703008208 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 568703008209 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568703008210 putative NAD(P) binding site [chemical binding]; other site 568703008211 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 568703008212 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703008213 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 568703008214 PAS domain S-box; Region: sensory_box; TIGR00229 568703008215 PAS domain; Region: PAS; smart00091 568703008216 putative active site [active] 568703008217 heme pocket [chemical binding]; other site 568703008218 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 568703008219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703008220 active site 568703008221 phosphorylation site [posttranslational modification] 568703008222 intermolecular recognition site; other site 568703008223 dimerization interface [polypeptide binding]; other site 568703008224 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568703008225 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 568703008226 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703008227 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 568703008228 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568703008229 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703008230 catalytic triad [active] 568703008231 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568703008232 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703008233 Int/Topo IB signature motif; other site 568703008234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703008235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008236 non-specific DNA binding site [nucleotide binding]; other site 568703008237 salt bridge; other site 568703008238 sequence-specific DNA binding site [nucleotide binding]; other site 568703008239 Helix-turn-helix domain; Region: HTH_17; cl17695 568703008240 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 568703008241 polymerase nucleotide-binding site; other site 568703008242 DNA-binding residues [nucleotide binding]; DNA binding site 568703008243 nucleotide binding site [chemical binding]; other site 568703008244 primase nucleotide-binding site [nucleotide binding]; other site 568703008245 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 568703008246 Virulence-associated protein E; Region: VirE; pfam05272 568703008247 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 568703008248 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568703008249 active site 568703008250 Phage terminase, small subunit; Region: Terminase_4; pfam05119 568703008251 Phage Terminase; Region: Terminase_1; pfam03354 568703008252 Phage portal protein; Region: Phage_portal; pfam04860 568703008253 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568703008254 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 568703008255 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568703008256 Phage capsid family; Region: Phage_capsid; pfam05065 568703008257 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568703008258 oligomerization interface [polypeptide binding]; other site 568703008259 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 568703008260 Predicted membrane protein [Function unknown]; Region: COG2261 568703008261 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568703008262 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568703008263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703008264 active site 568703008265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703008266 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568703008267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568703008268 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 568703008269 substrate binding pocket [chemical binding]; other site 568703008270 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703008271 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 568703008272 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703008273 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703008274 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703008275 active site 568703008276 phosphorylation site [posttranslational modification] 568703008277 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703008278 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568703008279 DNA-binding interface [nucleotide binding]; DNA binding site 568703008280 PRD domain; Region: PRD; pfam00874 568703008281 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703008282 active site 568703008283 P-loop; other site 568703008284 phosphorylation site [posttranslational modification] 568703008285 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703008286 active site 568703008287 phosphorylation site [posttranslational modification] 568703008288 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 568703008289 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 568703008290 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 568703008291 active site 568703008292 P-loop; other site 568703008293 phosphorylation site [posttranslational modification] 568703008294 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 568703008295 active site 568703008296 P-loop; other site 568703008297 phosphorylation site [posttranslational modification] 568703008298 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 568703008299 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 568703008300 active site 568703008301 trimer interface [polypeptide binding]; other site 568703008302 allosteric site; other site 568703008303 active site lid [active] 568703008304 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703008305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703008306 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703008307 active site 568703008308 motif I; other site 568703008309 motif II; other site 568703008310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703008311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008312 non-specific DNA binding site [nucleotide binding]; other site 568703008313 salt bridge; other site 568703008314 sequence-specific DNA binding site [nucleotide binding]; other site 568703008315 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703008316 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703008317 HlyD family secretion protein; Region: HlyD_2; pfam12700 568703008318 HlyD family secretion protein; Region: HlyD_3; pfam13437 568703008319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703008320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703008321 Walker A/P-loop; other site 568703008322 ATP binding site [chemical binding]; other site 568703008323 Q-loop/lid; other site 568703008324 ABC transporter signature motif; other site 568703008325 Walker B; other site 568703008326 D-loop; other site 568703008327 H-loop/switch region; other site 568703008328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703008329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703008330 FtsX-like permease family; Region: FtsX; pfam02687 568703008331 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703008332 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008333 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008334 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008335 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008336 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703008337 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703008338 transaminase; Reviewed; Region: PRK08068 568703008339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703008340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703008341 homodimer interface [polypeptide binding]; other site 568703008342 catalytic residue [active] 568703008343 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568703008344 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 568703008345 putative active site [active] 568703008346 catalytic triad [active] 568703008347 putative dimer interface [polypeptide binding]; other site 568703008348 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568703008349 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703008350 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 568703008351 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 568703008352 putative active site [active] 568703008353 metal binding site [ion binding]; metal-binding site 568703008354 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703008355 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 568703008356 metal binding site [ion binding]; metal-binding site 568703008357 dimer interface [polypeptide binding]; other site 568703008358 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703008359 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703008360 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703008361 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703008362 Walker A/P-loop; other site 568703008363 ATP binding site [chemical binding]; other site 568703008364 ABC transporter; Region: ABC_tran; pfam00005 568703008365 Q-loop/lid; other site 568703008366 ABC transporter signature motif; other site 568703008367 Walker B; other site 568703008368 D-loop; other site 568703008369 H-loop/switch region; other site 568703008370 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568703008371 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 568703008372 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 568703008373 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568703008374 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568703008375 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568703008376 G1 box; other site 568703008377 GTP/Mg2+ binding site [chemical binding]; other site 568703008378 Switch I region; other site 568703008379 G2 box; other site 568703008380 Switch II region; other site 568703008381 G3 box; other site 568703008382 G4 box; other site 568703008383 G5 box; other site 568703008384 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568703008385 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 568703008386 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 568703008387 G-X-X-G motif; other site 568703008388 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 568703008389 RxxxH motif; other site 568703008390 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 568703008391 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703008392 ribonuclease P; Reviewed; Region: rnpA; PRK00499 568703008393 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568703008394 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008395 Winged helix-turn helix; Region: HTH_29; pfam13551 568703008396 Integrase core domain; Region: rve; pfam00665