-- dump date 20140619_124910 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1069534000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1069534000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1069534000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000004 Walker A motif; other site 1069534000005 ATP binding site [chemical binding]; other site 1069534000006 Walker B motif; other site 1069534000007 arginine finger; other site 1069534000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1069534000009 DnaA box-binding interface [nucleotide binding]; other site 1069534000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1069534000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1069534000012 putative DNA binding surface [nucleotide binding]; other site 1069534000013 dimer interface [polypeptide binding]; other site 1069534000014 beta-clamp/clamp loader binding surface; other site 1069534000015 beta-clamp/translesion DNA polymerase binding surface; other site 1069534000016 S4 domain; Region: S4_2; pfam13275 1069534000017 recombination protein F; Reviewed; Region: recF; PRK00064 1069534000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1069534000019 Walker A/P-loop; other site 1069534000020 ATP binding site [chemical binding]; other site 1069534000021 Q-loop/lid; other site 1069534000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534000023 ABC transporter signature motif; other site 1069534000024 Walker B; other site 1069534000025 D-loop; other site 1069534000026 H-loop/switch region; other site 1069534000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1069534000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534000029 Mg2+ binding site [ion binding]; other site 1069534000030 G-X-G motif; other site 1069534000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1069534000032 anchoring element; other site 1069534000033 dimer interface [polypeptide binding]; other site 1069534000034 ATP binding site [chemical binding]; other site 1069534000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1069534000036 active site 1069534000037 putative metal-binding site [ion binding]; other site 1069534000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1069534000039 DNA gyrase subunit A; Validated; Region: PRK05560 1069534000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1069534000041 CAP-like domain; other site 1069534000042 active site 1069534000043 primary dimer interface [polypeptide binding]; other site 1069534000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1069534000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1069534000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1069534000052 dimer interface [polypeptide binding]; other site 1069534000053 ssDNA binding site [nucleotide binding]; other site 1069534000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1069534000055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1069534000056 Predicted secreted protein [Function unknown]; Region: COG4086 1069534000057 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1069534000058 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1069534000059 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1069534000060 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1069534000061 DHH family; Region: DHH; pfam01368 1069534000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1069534000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1069534000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1069534000065 replicative DNA helicase; Region: DnaB; TIGR00665 1069534000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1069534000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1069534000068 Walker A motif; other site 1069534000069 ATP binding site [chemical binding]; other site 1069534000070 Walker B motif; other site 1069534000071 DNA binding loops [nucleotide binding] 1069534000072 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1069534000073 putative substrate binding pocket [chemical binding]; other site 1069534000074 AC domain interface; other site 1069534000075 catalytic triad [active] 1069534000076 AB domain interface; other site 1069534000077 interchain disulfide; other site 1069534000078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534000079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534000080 putative substrate translocation pore; other site 1069534000081 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1069534000082 amidase; Provisional; Region: PRK06529 1069534000083 Amidase; Region: Amidase; cl11426 1069534000084 oligoendopeptidase F; Region: pepF; TIGR00181 1069534000085 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1069534000086 active site 1069534000087 Zn binding site [ion binding]; other site 1069534000088 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1069534000089 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1069534000090 Na binding site [ion binding]; other site 1069534000091 cytosine deaminase; Provisional; Region: PRK09230 1069534000092 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1069534000093 active site 1069534000094 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1069534000095 conserved cys residue [active] 1069534000096 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1069534000097 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1069534000098 dimer interface [polypeptide binding]; other site 1069534000099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534000100 catalytic residue [active] 1069534000101 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1069534000102 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1069534000103 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1069534000104 GDP-binding site [chemical binding]; other site 1069534000105 ACT binding site; other site 1069534000106 IMP binding site; other site 1069534000107 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1069534000108 Pyruvate formate lyase 1; Region: PFL1; cd01678 1069534000109 coenzyme A binding site [chemical binding]; other site 1069534000110 active site 1069534000111 catalytic residues [active] 1069534000112 glycine loop; other site 1069534000113 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1069534000114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1069534000115 FeS/SAM binding site; other site 1069534000116 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1069534000117 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1069534000118 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1069534000119 Nucleoside recognition; Region: Gate; pfam07670 1069534000120 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1069534000121 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1069534000122 substrate binding site [chemical binding]; other site 1069534000123 ATP binding site [chemical binding]; other site 1069534000124 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1069534000125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534000127 active site 1069534000128 phosphorylation site [posttranslational modification] 1069534000129 intermolecular recognition site; other site 1069534000130 dimerization interface [polypeptide binding]; other site 1069534000131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534000132 DNA binding site [nucleotide binding] 1069534000133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1069534000134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1069534000135 dimerization interface [polypeptide binding]; other site 1069534000136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1069534000137 putative active site [active] 1069534000138 heme pocket [chemical binding]; other site 1069534000139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1069534000140 dimer interface [polypeptide binding]; other site 1069534000141 phosphorylation site [posttranslational modification] 1069534000142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534000143 ATP binding site [chemical binding]; other site 1069534000144 Mg2+ binding site [ion binding]; other site 1069534000145 G-X-G motif; other site 1069534000146 YycH protein; Region: YycH; pfam07435 1069534000147 YycH protein; Region: YycI; pfam09648 1069534000148 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1069534000149 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1069534000150 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1069534000151 protein binding site [polypeptide binding]; other site 1069534000152 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1069534000153 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1069534000154 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534000155 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534000156 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534000157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1069534000158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1069534000159 active site 1069534000160 metal binding site [ion binding]; metal-binding site 1069534000161 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534000162 Similar to Transposase; predicted to be nonfuncional due to frameshift 1069534000163 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1069534000164 active site 1069534000165 catalytic motif [active] 1069534000166 Zn binding site [ion binding]; other site 1069534000167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000168 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1069534000169 Walker A motif; other site 1069534000170 ATP binding site [chemical binding]; other site 1069534000171 Walker B motif; other site 1069534000172 arginine finger; other site 1069534000173 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1069534000174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000175 Walker A motif; other site 1069534000176 ATP binding site [chemical binding]; other site 1069534000177 Walker B motif; other site 1069534000178 arginine finger; other site 1069534000179 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1069534000180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1069534000181 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1069534000182 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1069534000183 Substrate-binding site [chemical binding]; other site 1069534000184 Substrate specificity [chemical binding]; other site 1069534000185 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1069534000186 Ligand Binding Site [chemical binding]; other site 1069534000187 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1069534000188 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1069534000189 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1069534000190 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1069534000191 homodimer interface [polypeptide binding]; other site 1069534000192 substrate-cofactor binding pocket; other site 1069534000193 catalytic residue [active] 1069534000194 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1069534000195 Collagen binding domain; Region: Collagen_bind; pfam05737 1069534000196 Collagen binding domain; Region: Collagen_bind; pfam05737 1069534000197 Collagen binding domain; Region: Collagen_bind; pfam05737 1069534000198 Cna protein B-type domain; Region: Cna_B; pfam05738 1069534000199 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1069534000200 Cna protein B-type domain; Region: Cna_B; pfam05738 1069534000201 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1069534000202 active site 1069534000203 catalytic site [active] 1069534000204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1069534000205 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1069534000206 nudix motif; other site 1069534000207 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1069534000208 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1069534000209 active site 1069534000210 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1069534000211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1069534000212 MarR family; Region: MarR_2; pfam12802 1069534000213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534000214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534000215 putative substrate translocation pore; other site 1069534000216 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1069534000217 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1069534000218 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1069534000219 Aspartase; Region: Aspartase; cd01357 1069534000220 active sites [active] 1069534000221 tetramer interface [polypeptide binding]; other site 1069534000222 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1069534000223 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1069534000224 putative DNA binding site [nucleotide binding]; other site 1069534000225 putative Zn2+ binding site [ion binding]; other site 1069534000226 AsnC family; Region: AsnC_trans_reg; pfam01037 1069534000227 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1069534000228 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1069534000229 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1069534000230 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1069534000231 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1069534000232 putative substrate binding site [chemical binding]; other site 1069534000233 putative ATP binding site [chemical binding]; other site 1069534000234 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1069534000235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1069534000236 active site 1069534000237 phosphorylation site [posttranslational modification] 1069534000238 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1069534000239 active site 1069534000240 P-loop; other site 1069534000241 phosphorylation site [posttranslational modification] 1069534000242 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1069534000243 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 1069534000244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1069534000245 RloB-like protein; Region: RloB; pfam13707 1069534000246 AAA domain; Region: AAA_21; pfam13304 1069534000247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534000248 Walker B; other site 1069534000249 D-loop; other site 1069534000250 H-loop/switch region; other site 1069534000251 Chain length determinant protein; Region: Wzz; cl15801 1069534000252 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1069534000253 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1069534000254 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1069534000255 Nucleotide binding site [chemical binding]; other site 1069534000256 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1069534000257 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1069534000258 CoA binding domain; Region: CoA_binding; cl17356 1069534000259 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1069534000260 NAD(P) binding site [chemical binding]; other site 1069534000261 homodimer interface [polypeptide binding]; other site 1069534000262 substrate binding site [chemical binding]; other site 1069534000263 active site 1069534000264 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1069534000265 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1069534000266 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1069534000267 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1069534000268 catalytic residue [active] 1069534000269 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1069534000270 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1069534000271 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1069534000272 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1069534000273 homodimer interface [polypeptide binding]; other site 1069534000274 substrate-cofactor binding pocket; other site 1069534000275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534000276 catalytic residue [active] 1069534000277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1069534000278 active site 1069534000279 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1069534000280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1069534000281 NAD(P) binding site [chemical binding]; other site 1069534000282 active site 1069534000283 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1069534000284 trimer interface [polypeptide binding]; other site 1069534000285 active site 1069534000286 substrate binding site [chemical binding]; other site 1069534000287 CoA binding site [chemical binding]; other site 1069534000288 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1069534000289 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1069534000290 Probable Catalytic site; other site 1069534000291 putative glycosyl transferase; Provisional; Region: PRK10073 1069534000292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1069534000293 active site 1069534000294 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 1069534000295 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1069534000296 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1069534000297 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1069534000298 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1069534000299 Similar to transposase; Predicted to be non-functional due to truncation 1069534000300 AAA domain; Region: AAA_21; pfam13304 1069534000301 Transposase; Region: HTH_Tnp_1; cl17663 1069534000302 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534000303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534000304 salt bridge; other site 1069534000305 non-specific DNA binding site [nucleotide binding]; other site 1069534000306 sequence-specific DNA binding site [nucleotide binding]; other site 1069534000307 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1069534000308 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1069534000309 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1069534000310 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1069534000311 Similar to Hypothetical protein; predicted to be nonfuntional due to truncation 1069534000312 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1069534000313 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1069534000314 substrate binding site; other site 1069534000315 tetramer interface; other site 1069534000316 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1069534000317 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1069534000318 NAD binding site [chemical binding]; other site 1069534000319 substrate binding site [chemical binding]; other site 1069534000320 homodimer interface [polypeptide binding]; other site 1069534000321 active site 1069534000322 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1069534000323 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1069534000324 NADP binding site [chemical binding]; other site 1069534000325 active site 1069534000326 putative substrate binding site [chemical binding]; other site 1069534000327 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1069534000328 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1069534000329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1069534000330 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1069534000331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1069534000332 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1069534000333 EDD domain protein, DegV family; Region: DegV; TIGR00762 1069534000334 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1069534000335 Predicted membrane protein [Function unknown]; Region: COG2246 1069534000336 GtrA-like protein; Region: GtrA; pfam04138 1069534000337 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1069534000338 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1069534000339 Ligand binding site; other site 1069534000340 Putative Catalytic site; other site 1069534000341 DXD motif; other site 1069534000342 similar to Bacterial membrane protein; predicted to be non-functional due to insertion of IS element 1069534000343 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534000344 MULE transposase domain; Region: MULE; pfam10551 1069534000345 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1069534000346 Putative Catalytic site; other site 1069534000347 DXD motif; other site 1069534000348 Predicted integral membrane protein [Function unknown]; Region: COG5617 1069534000349 Similar to yfhO membrane protein; predicte to be non funtional due to insertion of IS element 1069534000350 Similar to transposase; predicted to be non-functional due to truncation 1069534000351 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1069534000352 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1069534000353 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1069534000354 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1069534000355 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1069534000356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534000357 catalytic residue [active] 1069534000358 homoserine dehydrogenase; Provisional; Region: PRK06349 1069534000359 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1069534000360 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1069534000361 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1069534000362 homoserine kinase; Provisional; Region: PRK01212 1069534000363 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1069534000364 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1069534000365 Predicted integral membrane protein [Function unknown]; Region: COG5542 1069534000366 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534000367 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534000368 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1069534000369 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1069534000370 Ligand binding site; other site 1069534000371 Putative Catalytic site; other site 1069534000372 DXD motif; other site 1069534000373 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1069534000374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1069534000375 active site 1069534000376 LicD family; Region: LicD; cl01378 1069534000377 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1069534000378 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1069534000379 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1069534000380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1069534000381 UDP-galactopyranose mutase; Region: GLF; pfam03275 1069534000382 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1069534000383 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1069534000384 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1069534000385 putative glycosyl transferase; Provisional; Region: PRK10073 1069534000386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1069534000387 active site 1069534000388 AAA domain; Region: AAA_21; pfam13304 1069534000389 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1069534000390 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1069534000391 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1069534000392 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1069534000393 substrate binding site; other site 1069534000394 dimer interface; other site 1069534000395 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1069534000396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1069534000397 NAD(P) binding site [chemical binding]; other site 1069534000398 active site 1069534000399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534000400 non-specific DNA binding site [nucleotide binding]; other site 1069534000401 salt bridge; other site 1069534000402 sequence-specific DNA binding site [nucleotide binding]; other site 1069534000403 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534000404 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534000405 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534000406 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1069534000407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534000408 Coenzyme A binding pocket [chemical binding]; other site 1069534000409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534000410 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1069534000411 active site 1069534000412 motif I; other site 1069534000413 motif II; other site 1069534000414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534000415 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1069534000416 catalytic residues [active] 1069534000417 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1069534000418 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1069534000419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1069534000420 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1069534000421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534000422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534000423 active site 1069534000424 phosphorylation site [posttranslational modification] 1069534000425 intermolecular recognition site; other site 1069534000426 dimerization interface [polypeptide binding]; other site 1069534000427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534000428 DNA binding site [nucleotide binding] 1069534000429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1069534000430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534000431 ATP binding site [chemical binding]; other site 1069534000432 Mg2+ binding site [ion binding]; other site 1069534000433 G-X-G motif; other site 1069534000434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534000435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1069534000436 Walker A/P-loop; other site 1069534000437 ATP binding site [chemical binding]; other site 1069534000438 Q-loop/lid; other site 1069534000439 ABC transporter signature motif; other site 1069534000440 Walker B; other site 1069534000441 D-loop; other site 1069534000442 H-loop/switch region; other site 1069534000443 FtsX-like permease family; Region: FtsX; pfam02687 1069534000444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1069534000445 classical (c) SDRs; Region: SDR_c; cd05233 1069534000446 NAD(P) binding site [chemical binding]; other site 1069534000447 active site 1069534000448 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1069534000449 QueT transporter; Region: QueT; pfam06177 1069534000450 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1069534000451 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1069534000452 active site 1069534000453 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534000454 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1069534000455 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534000456 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1069534000457 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1069534000458 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1069534000459 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1069534000460 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1069534000461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1069534000462 dimer interface [polypeptide binding]; other site 1069534000463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1069534000464 metal binding site [ion binding]; metal-binding site 1069534000465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1069534000466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1069534000467 nucleotide binding site [chemical binding]; other site 1069534000468 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534000469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534000470 DNA-binding site [nucleotide binding]; DNA binding site 1069534000471 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534000472 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1069534000473 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1069534000474 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1069534000475 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1069534000476 active site 1069534000477 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1069534000478 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 1069534000479 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1069534000480 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1069534000481 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1069534000482 peptide binding site [polypeptide binding]; other site 1069534000483 amino acid transporter; Region: 2A0306; TIGR00909 1069534000484 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1069534000485 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1069534000486 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1069534000487 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1069534000488 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1069534000489 active site 1069534000490 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1069534000491 metal binding site 2 [ion binding]; metal-binding site 1069534000492 putative DNA binding helix; other site 1069534000493 metal binding site 1 [ion binding]; metal-binding site 1069534000494 dimer interface [polypeptide binding]; other site 1069534000495 structural Zn2+ binding site [ion binding]; other site 1069534000496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534000497 Coenzyme A binding pocket [chemical binding]; other site 1069534000498 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1069534000499 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1069534000500 HflX GTPase family; Region: HflX; cd01878 1069534000501 G1 box; other site 1069534000502 GTP/Mg2+ binding site [chemical binding]; other site 1069534000503 Switch I region; other site 1069534000504 G2 box; other site 1069534000505 G3 box; other site 1069534000506 Switch II region; other site 1069534000507 G4 box; other site 1069534000508 G5 box; other site 1069534000509 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1069534000510 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1069534000511 peptide binding site [polypeptide binding]; other site 1069534000512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1069534000513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534000514 dimer interface [polypeptide binding]; other site 1069534000515 conserved gate region; other site 1069534000516 putative PBP binding loops; other site 1069534000517 ABC-ATPase subunit interface; other site 1069534000518 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1069534000519 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1069534000520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534000521 dimer interface [polypeptide binding]; other site 1069534000522 conserved gate region; other site 1069534000523 putative PBP binding loops; other site 1069534000524 ABC-ATPase subunit interface; other site 1069534000525 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1069534000526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1069534000527 Walker A/P-loop; other site 1069534000528 ATP binding site [chemical binding]; other site 1069534000529 Q-loop/lid; other site 1069534000530 ABC transporter signature motif; other site 1069534000531 Walker B; other site 1069534000532 D-loop; other site 1069534000533 H-loop/switch region; other site 1069534000534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1069534000535 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1069534000536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1069534000537 Walker A/P-loop; other site 1069534000538 ATP binding site [chemical binding]; other site 1069534000539 Q-loop/lid; other site 1069534000540 ABC transporter signature motif; other site 1069534000541 Walker B; other site 1069534000542 D-loop; other site 1069534000543 H-loop/switch region; other site 1069534000544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1069534000545 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1069534000546 Similar to ABC transporter, ATP-binding protein; predicted to be non-functional due to Frameshift 1069534000547 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1069534000548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534000549 Probable transposase; Region: OrfB_IS605; pfam01385 1069534000550 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534000551 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1069534000552 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1069534000553 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1069534000554 gamma-glutamyl kinase; Provisional; Region: PRK05429 1069534000555 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1069534000556 nucleotide binding site [chemical binding]; other site 1069534000557 homotetrameric interface [polypeptide binding]; other site 1069534000558 putative phosphate binding site [ion binding]; other site 1069534000559 putative allosteric binding site; other site 1069534000560 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1069534000561 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1069534000562 putative catalytic cysteine [active] 1069534000563 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1069534000564 dimer interface [polypeptide binding]; other site 1069534000565 FMN binding site [chemical binding]; other site 1069534000566 NADPH bind site [chemical binding]; other site 1069534000567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534000568 Transposase; Region: HTH_Tnp_1; cl17663 1069534000569 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534000570 HTH-like domain; Region: HTH_21; pfam13276 1069534000571 Integrase core domain; Region: rve; pfam00665 1069534000572 Integrase core domain; Region: rve_2; pfam13333 1069534000573 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1069534000574 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1069534000575 Ligand binding site; other site 1069534000576 metal-binding site 1069534000577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534000578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534000579 active site 1069534000580 phosphorylation site [posttranslational modification] 1069534000581 intermolecular recognition site; other site 1069534000582 dimerization interface [polypeptide binding]; other site 1069534000583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534000584 DNA binding site [nucleotide binding] 1069534000585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1069534000586 dimer interface [polypeptide binding]; other site 1069534000587 phosphorylation site [posttranslational modification] 1069534000588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534000589 ATP binding site [chemical binding]; other site 1069534000590 Mg2+ binding site [ion binding]; other site 1069534000591 G-X-G motif; other site 1069534000592 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1069534000593 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1069534000594 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1069534000595 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1069534000596 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1069534000597 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1069534000598 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1069534000599 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1069534000600 EDD domain protein, DegV family; Region: DegV; TIGR00762 1069534000601 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1069534000602 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1069534000603 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1069534000604 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1069534000605 AzlC protein; Region: AzlC; pfam03591 1069534000606 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1069534000607 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1069534000608 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1069534000609 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534000610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534000611 DNA-binding site [nucleotide binding]; DNA binding site 1069534000612 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534000613 similar to Acetylxylan esterase; predicted to be non-functional due to truncation 1069534000614 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1069534000615 beta-galactosidase; Region: BGL; TIGR03356 1069534000616 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1069534000617 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1069534000618 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1069534000619 active site 1069534000620 P-loop; other site 1069534000621 phosphorylation site [posttranslational modification] 1069534000622 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1069534000623 active site 1069534000624 methionine cluster; other site 1069534000625 phosphorylation site [posttranslational modification] 1069534000626 metal binding site [ion binding]; metal-binding site 1069534000627 Similar to Transposase; predicted to be non-functional due to truncation 1069534000628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1069534000629 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1069534000630 nucleotide binding site [chemical binding]; other site 1069534000631 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1069534000632 beta-galactosidase; Region: BGL; TIGR03356 1069534000633 HlyD family secretion protein; Region: HlyD_2; pfam12700 1069534000634 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1069534000635 HlyD family secretion protein; Region: HlyD_3; pfam13437 1069534000636 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534000637 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1069534000638 Walker A/P-loop; other site 1069534000639 ATP binding site [chemical binding]; other site 1069534000640 Q-loop/lid; other site 1069534000641 ABC transporter signature motif; other site 1069534000642 Walker B; other site 1069534000643 D-loop; other site 1069534000644 H-loop/switch region; other site 1069534000645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1069534000646 FtsX-like permease family; Region: FtsX; pfam02687 1069534000647 similar to hypothetical protein; predicted to be non functional due to truncation 1069534000648 similar to hypothetical protein; predicted to be non functional due to truncation 1069534000649 similar to hypothetical protein; predicted to be non functional due to truncation 1069534000650 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1069534000651 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1069534000652 active site 1069534000653 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1069534000654 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1069534000655 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1069534000656 FeoA domain; Region: FeoA; pfam04023 1069534000657 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1069534000658 DNA-binding site [nucleotide binding]; DNA binding site 1069534000659 RNA-binding motif; other site 1069534000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534000661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534000662 putative substrate translocation pore; other site 1069534000663 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1069534000664 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1069534000665 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1069534000666 similar to Transposease; predicted to be non-functional due to frameshifts 1069534000667 Similar to hypothetical protein; predicted to be non-functional due to truncation 1069534000668 HTH-like domain; Region: HTH_21; pfam13276 1069534000669 Integrase core domain; Region: rve; pfam00665 1069534000670 Integrase core domain; Region: rve_2; pfam13333 1069534000671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534000672 Transposase; Region: HTH_Tnp_1; cl17663 1069534000673 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534000674 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1069534000675 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1069534000676 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1069534000677 Double zinc ribbon; Region: DZR; pfam12773 1069534000678 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1069534000679 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1069534000680 Predicted transcriptional regulator [Transcription]; Region: COG1959 1069534000681 Transcriptional regulator; Region: Rrf2; pfam02082 1069534000682 lysine transporter; Provisional; Region: PRK10836 1069534000683 seryl-tRNA synthetase; Provisional; Region: PRK05431 1069534000684 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1069534000685 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1069534000686 dimer interface [polypeptide binding]; other site 1069534000687 active site 1069534000688 motif 1; other site 1069534000689 motif 2; other site 1069534000690 motif 3; other site 1069534000691 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534000692 catalytic core [active] 1069534000693 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1069534000694 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1069534000695 Clp amino terminal domain; Region: Clp_N; pfam02861 1069534000696 Clp amino terminal domain; Region: Clp_N; pfam02861 1069534000697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000698 Walker A motif; other site 1069534000699 ATP binding site [chemical binding]; other site 1069534000700 Walker B motif; other site 1069534000701 arginine finger; other site 1069534000702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000703 Walker A motif; other site 1069534000704 ATP binding site [chemical binding]; other site 1069534000705 Walker B motif; other site 1069534000706 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1069534000707 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1069534000708 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1069534000709 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1069534000710 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1069534000711 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1069534000712 RPB1 interaction site [polypeptide binding]; other site 1069534000713 RPB10 interaction site [polypeptide binding]; other site 1069534000714 RPB11 interaction site [polypeptide binding]; other site 1069534000715 RPB3 interaction site [polypeptide binding]; other site 1069534000716 RPB12 interaction site [polypeptide binding]; other site 1069534000717 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1069534000718 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1069534000719 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1069534000720 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1069534000721 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1069534000722 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1069534000723 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1069534000724 DNA binding site [nucleotide binding] 1069534000725 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1069534000726 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1069534000727 active site 1069534000728 tetramer interface [polypeptide binding]; other site 1069534000729 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1069534000730 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1069534000731 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1069534000732 S17 interaction site [polypeptide binding]; other site 1069534000733 S8 interaction site; other site 1069534000734 16S rRNA interaction site [nucleotide binding]; other site 1069534000735 streptomycin interaction site [chemical binding]; other site 1069534000736 23S rRNA interaction site [nucleotide binding]; other site 1069534000737 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1069534000738 30S ribosomal protein S7; Validated; Region: PRK05302 1069534000739 elongation factor G; Reviewed; Region: PRK12739 1069534000740 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1069534000741 G1 box; other site 1069534000742 putative GEF interaction site [polypeptide binding]; other site 1069534000743 GTP/Mg2+ binding site [chemical binding]; other site 1069534000744 Switch I region; other site 1069534000745 G2 box; other site 1069534000746 G3 box; other site 1069534000747 Switch II region; other site 1069534000748 G4 box; other site 1069534000749 G5 box; other site 1069534000750 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1069534000751 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1069534000752 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1069534000753 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1069534000754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534000755 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1069534000756 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1069534000757 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1069534000758 H+ Antiporter protein; Region: 2A0121; TIGR00900 1069534000759 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1069534000760 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1069534000761 alanine--tRNA ligase; Region: alaS; TIGR00344 1069534000762 Isochorismatase family; Region: Isochorismatase; pfam00857 1069534000763 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1069534000764 catalytic triad [active] 1069534000765 conserved cis-peptide bond; other site 1069534000766 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1069534000767 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1069534000768 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1069534000769 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1069534000770 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1069534000771 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1069534000772 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1069534000773 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1069534000774 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1069534000775 putative translocon binding site; other site 1069534000776 protein-rRNA interface [nucleotide binding]; other site 1069534000777 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1069534000778 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1069534000779 G-X-X-G motif; other site 1069534000780 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1069534000781 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1069534000782 23S rRNA interface [nucleotide binding]; other site 1069534000783 5S rRNA interface [nucleotide binding]; other site 1069534000784 putative antibiotic binding site [chemical binding]; other site 1069534000785 L25 interface [polypeptide binding]; other site 1069534000786 L27 interface [polypeptide binding]; other site 1069534000787 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1069534000788 L23 interface [polypeptide binding]; other site 1069534000789 trigger factor interaction site; other site 1069534000790 23S rRNA interface [nucleotide binding]; other site 1069534000791 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1069534000792 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1069534000793 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1069534000794 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1069534000795 RNA binding site [nucleotide binding]; other site 1069534000796 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1069534000797 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1069534000798 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1069534000799 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1069534000800 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1069534000801 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1069534000802 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1069534000803 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1069534000804 5S rRNA interface [nucleotide binding]; other site 1069534000805 L27 interface [polypeptide binding]; other site 1069534000806 23S rRNA interface [nucleotide binding]; other site 1069534000807 L5 interface [polypeptide binding]; other site 1069534000808 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1069534000809 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1069534000810 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1069534000811 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1069534000812 23S rRNA binding site [nucleotide binding]; other site 1069534000813 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1069534000814 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1069534000815 SecY translocase; Region: SecY; pfam00344 1069534000816 adenylate kinase; Reviewed; Region: adk; PRK00279 1069534000817 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1069534000818 AMP-binding site [chemical binding]; other site 1069534000819 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1069534000820 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1069534000821 rRNA binding site [nucleotide binding]; other site 1069534000822 predicted 30S ribosome binding site; other site 1069534000823 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1069534000824 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1069534000825 30S ribosomal protein S11; Validated; Region: PRK05309 1069534000826 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1069534000827 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1069534000828 alphaNTD homodimer interface [polypeptide binding]; other site 1069534000829 alphaNTD - beta interaction site [polypeptide binding]; other site 1069534000830 alphaNTD - beta' interaction site [polypeptide binding]; other site 1069534000831 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1069534000832 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1069534000833 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1069534000834 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534000835 Walker A/P-loop; other site 1069534000836 ATP binding site [chemical binding]; other site 1069534000837 Q-loop/lid; other site 1069534000838 ABC transporter signature motif; other site 1069534000839 Walker B; other site 1069534000840 D-loop; other site 1069534000841 H-loop/switch region; other site 1069534000842 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1069534000843 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534000844 Walker A/P-loop; other site 1069534000845 ATP binding site [chemical binding]; other site 1069534000846 Q-loop/lid; other site 1069534000847 ABC transporter signature motif; other site 1069534000848 Walker B; other site 1069534000849 D-loop; other site 1069534000850 H-loop/switch region; other site 1069534000851 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1069534000852 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1069534000853 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1069534000854 dimerization interface 3.5A [polypeptide binding]; other site 1069534000855 active site 1069534000856 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1069534000857 23S rRNA interface [nucleotide binding]; other site 1069534000858 L3 interface [polypeptide binding]; other site 1069534000859 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1069534000860 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1069534000861 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1069534000862 maltose O-acetyltransferase; Provisional; Region: PRK10092 1069534000863 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1069534000864 active site 1069534000865 substrate binding site [chemical binding]; other site 1069534000866 trimer interface [polypeptide binding]; other site 1069534000867 CoA binding site [chemical binding]; other site 1069534000868 maltose O-acetyltransferase; Provisional; Region: PRK10092 1069534000869 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1069534000870 active site 1069534000871 substrate binding site [chemical binding]; other site 1069534000872 trimer interface [polypeptide binding]; other site 1069534000873 CoA binding site [chemical binding]; other site 1069534000874 DNA topoisomerase III; Provisional; Region: PRK07726 1069534000875 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1069534000876 active site 1069534000877 putative interdomain interaction site [polypeptide binding]; other site 1069534000878 putative metal-binding site [ion binding]; other site 1069534000879 putative nucleotide binding site [chemical binding]; other site 1069534000880 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1069534000881 domain I; other site 1069534000882 DNA binding groove [nucleotide binding] 1069534000883 phosphate binding site [ion binding]; other site 1069534000884 domain II; other site 1069534000885 domain III; other site 1069534000886 nucleotide binding site [chemical binding]; other site 1069534000887 catalytic site [active] 1069534000888 domain IV; other site 1069534000889 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1069534000890 Protein of unknown function (DUF454); Region: DUF454; cl01063 1069534000891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1069534000892 binding surface 1069534000893 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1069534000894 TPR motif; other site 1069534000895 AAA domain; Region: AAA_30; pfam13604 1069534000896 Family description; Region: UvrD_C_2; pfam13538 1069534000897 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1069534000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534000899 S-adenosylmethionine binding site [chemical binding]; other site 1069534000900 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1069534000901 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1069534000902 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1069534000903 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1069534000904 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1069534000905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1069534000906 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1069534000907 NAD binding site [chemical binding]; other site 1069534000908 dimer interface [polypeptide binding]; other site 1069534000909 substrate binding site [chemical binding]; other site 1069534000910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1069534000911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1069534000912 L-aspartate oxidase; Provisional; Region: PRK06175 1069534000913 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1069534000914 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1069534000915 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534000916 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534000917 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1069534000918 Walker A/P-loop; other site 1069534000919 ATP binding site [chemical binding]; other site 1069534000920 Q-loop/lid; other site 1069534000921 ABC transporter signature motif; other site 1069534000922 Walker B; other site 1069534000923 D-loop; other site 1069534000924 H-loop/switch region; other site 1069534000925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534000926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534000927 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1069534000928 Walker A/P-loop; other site 1069534000929 ATP binding site [chemical binding]; other site 1069534000930 Q-loop/lid; other site 1069534000931 ABC transporter signature motif; other site 1069534000932 Walker B; other site 1069534000933 D-loop; other site 1069534000934 H-loop/switch region; other site 1069534000935 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1069534000936 PhoH-like protein; Region: PhoH; cl17668 1069534000937 DEAD_2; Region: DEAD_2; pfam06733 1069534000938 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1069534000939 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1069534000940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 1069534000941 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534000942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534000943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534000944 Walker A/P-loop; other site 1069534000945 ATP binding site [chemical binding]; other site 1069534000946 Q-loop/lid; other site 1069534000947 ABC transporter signature motif; other site 1069534000948 Walker B; other site 1069534000949 D-loop; other site 1069534000950 H-loop/switch region; other site 1069534000951 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534000952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534000953 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1069534000954 Walker A/P-loop; other site 1069534000955 ATP binding site [chemical binding]; other site 1069534000956 Q-loop/lid; other site 1069534000957 ABC transporter signature motif; other site 1069534000958 Walker B; other site 1069534000959 D-loop; other site 1069534000960 H-loop/switch region; other site 1069534000961 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1069534000962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534000963 Coenzyme A binding pocket [chemical binding]; other site 1069534000964 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1069534000965 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1069534000966 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1069534000967 heat shock protein HtpX; Provisional; Region: PRK04897 1069534000968 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1069534000969 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1069534000970 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534000971 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1069534000972 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1069534000973 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1069534000974 ATP binding site [chemical binding]; other site 1069534000975 Mg++ binding site [ion binding]; other site 1069534000976 motif III; other site 1069534000977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534000978 nucleotide binding region [chemical binding]; other site 1069534000979 ATP-binding site [chemical binding]; other site 1069534000980 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1069534000981 alanine racemase; Reviewed; Region: alr; PRK00053 1069534000982 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1069534000983 active site 1069534000984 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1069534000985 dimer interface [polypeptide binding]; other site 1069534000986 substrate binding site [chemical binding]; other site 1069534000987 catalytic residues [active] 1069534000988 PemK-like protein; Region: PemK; pfam02452 1069534000989 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534000990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534000991 DNA-binding site [nucleotide binding]; DNA binding site 1069534000992 UTRA domain; Region: UTRA; pfam07702 1069534000993 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1069534000994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1069534000995 Integrase core domain; Region: rve; pfam00665 1069534000996 transposase/IS protein; Provisional; Region: PRK09183 1069534000997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534000998 Walker A motif; other site 1069534000999 ATP binding site [chemical binding]; other site 1069534001000 Walker B motif; other site 1069534001001 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1069534001002 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1069534001003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1069534001004 NAD binding site [chemical binding]; other site 1069534001005 dimer interface [polypeptide binding]; other site 1069534001006 substrate binding site [chemical binding]; other site 1069534001007 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1069534001008 putative active site [active] 1069534001009 catalytic residue [active] 1069534001010 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1069534001011 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1069534001012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534001013 ATP binding site [chemical binding]; other site 1069534001014 putative Mg++ binding site [ion binding]; other site 1069534001015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001016 nucleotide binding region [chemical binding]; other site 1069534001017 ATP-binding site [chemical binding]; other site 1069534001018 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1069534001019 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1069534001020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534001021 RNA binding surface [nucleotide binding]; other site 1069534001022 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1069534001023 Septum formation initiator; Region: DivIC; pfam04977 1069534001024 hypothetical protein; Provisional; Region: PRK08582 1069534001025 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1069534001026 RNA binding site [nucleotide binding]; other site 1069534001027 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1069534001028 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1069534001029 Ligand Binding Site [chemical binding]; other site 1069534001030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534001031 active site 1069534001032 FtsH Extracellular; Region: FtsH_ext; pfam06480 1069534001033 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1069534001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534001035 Walker A motif; other site 1069534001036 ATP binding site [chemical binding]; other site 1069534001037 Walker B motif; other site 1069534001038 arginine finger; other site 1069534001039 Peptidase family M41; Region: Peptidase_M41; pfam01434 1069534001040 Similar to Transposase; predicted to be non-functional due to truncation 1069534001041 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1069534001042 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1069534001043 dimerization interface [polypeptide binding]; other site 1069534001044 domain crossover interface; other site 1069534001045 redox-dependent activation switch; other site 1069534001046 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1069534001047 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1069534001048 FMN binding site [chemical binding]; other site 1069534001049 active site 1069534001050 catalytic residues [active] 1069534001051 substrate binding site [chemical binding]; other site 1069534001052 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1069534001053 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1069534001054 dimer interface [polypeptide binding]; other site 1069534001055 putative anticodon binding site; other site 1069534001056 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1069534001057 motif 1; other site 1069534001058 active site 1069534001059 motif 2; other site 1069534001060 motif 3; other site 1069534001061 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1069534001062 Similar to hypothetical protein. Predicted to be non-functional due to frameshift 1069534001063 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1069534001064 Similar to TypeIII restriction endonuclease; predicted to be non-functional due to trucation 1069534001065 SEFIR domain; Region: SEFIR; pfam08357 1069534001066 Cgr1 family; Region: Cgr1; pfam03879 1069534001067 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1069534001068 active site 1069534001069 homodimer interface [polypeptide binding]; other site 1069534001070 homotetramer interface [polypeptide binding]; other site 1069534001071 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1069534001072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534001073 putative substrate translocation pore; other site 1069534001074 POT family; Region: PTR2; cl17359 1069534001075 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1069534001076 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1069534001077 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1069534001078 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1069534001079 active site 1069534001080 dimer interface [polypeptide binding]; other site 1069534001081 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534001082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534001083 DNA-binding site [nucleotide binding]; DNA binding site 1069534001084 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534001085 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1069534001086 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1069534001087 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1069534001088 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1069534001089 homodimer interface [polypeptide binding]; other site 1069534001090 NAD binding pocket [chemical binding]; other site 1069534001091 ATP binding pocket [chemical binding]; other site 1069534001092 Mg binding site [ion binding]; other site 1069534001093 active-site loop [active] 1069534001094 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1069534001095 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1069534001096 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1069534001097 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1069534001098 RNA binding site [nucleotide binding]; other site 1069534001099 hypothetical protein; Provisional; Region: PRK04351 1069534001100 SprT homologues; Region: SprT; cl01182 1069534001101 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1069534001102 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1069534001103 dimer interface [polypeptide binding]; other site 1069534001104 active site 1069534001105 CoA binding pocket [chemical binding]; other site 1069534001106 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1069534001107 Membrane transport protein; Region: Mem_trans; pfam03547 1069534001108 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1069534001109 NlpC/P60 family; Region: NLPC_P60; pfam00877 1069534001110 FIST N domain; Region: FIST; pfam08495 1069534001111 FIST C domain; Region: FIST_C; pfam10442 1069534001112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534001113 dimer interface [polypeptide binding]; other site 1069534001114 putative CheW interface [polypeptide binding]; other site 1069534001115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534001116 catalytic core [active] 1069534001117 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1069534001118 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1069534001119 trimer interface [polypeptide binding]; other site 1069534001120 active site 1069534001121 G bulge; other site 1069534001122 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1069534001123 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1069534001124 active site 1069534001125 dimer interface [polypeptide binding]; other site 1069534001126 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1069534001127 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1069534001128 trimer interface [polypeptide binding]; other site 1069534001129 active site 1069534001130 DNA repair protein RadA; Provisional; Region: PRK11823 1069534001131 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1069534001132 Walker A motif/ATP binding site; other site 1069534001133 ATP binding site [chemical binding]; other site 1069534001134 Walker B motif; other site 1069534001135 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1069534001136 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1069534001137 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1069534001138 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1069534001139 putative active site [active] 1069534001140 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1069534001141 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1069534001142 HIGH motif; other site 1069534001143 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1069534001144 active site 1069534001145 KMSKS motif; other site 1069534001146 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1069534001147 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1069534001148 active site 1069534001149 HIGH motif; other site 1069534001150 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1069534001151 KMSKS motif; other site 1069534001152 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1069534001153 tRNA binding surface [nucleotide binding]; other site 1069534001154 anticodon binding site; other site 1069534001155 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1069534001156 active site 1069534001157 metal binding site [ion binding]; metal-binding site 1069534001158 dimerization interface [polypeptide binding]; other site 1069534001159 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1069534001160 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1069534001161 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1069534001162 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1069534001163 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1069534001164 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1069534001165 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1069534001166 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1069534001167 putative homodimer interface [polypeptide binding]; other site 1069534001168 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1069534001169 heterodimer interface [polypeptide binding]; other site 1069534001170 homodimer interface [polypeptide binding]; other site 1069534001171 Peptidase family C69; Region: Peptidase_C69; pfam03577 1069534001172 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1069534001173 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 1069534001174 putative active site [active] 1069534001175 metal binding site [ion binding]; metal-binding site 1069534001176 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1069534001177 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1069534001178 23S rRNA interface [nucleotide binding]; other site 1069534001179 L7/L12 interface [polypeptide binding]; other site 1069534001180 putative thiostrepton binding site; other site 1069534001181 L25 interface [polypeptide binding]; other site 1069534001182 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1069534001183 mRNA/rRNA interface [nucleotide binding]; other site 1069534001184 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1069534001185 23S rRNA interface [nucleotide binding]; other site 1069534001186 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1069534001187 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1069534001188 core dimer interface [polypeptide binding]; other site 1069534001189 peripheral dimer interface [polypeptide binding]; other site 1069534001190 L10 interface [polypeptide binding]; other site 1069534001191 L11 interface [polypeptide binding]; other site 1069534001192 putative EF-Tu interaction site [polypeptide binding]; other site 1069534001193 putative EF-G interaction site [polypeptide binding]; other site 1069534001194 Predicted integral membrane protein [Function unknown]; Region: COG0392 1069534001195 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1069534001196 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1069534001197 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1069534001198 propionate/acetate kinase; Provisional; Region: PRK12379 1069534001199 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1069534001200 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1069534001201 active site 1069534001202 metal binding site [ion binding]; metal-binding site 1069534001203 DNA binding site [nucleotide binding] 1069534001204 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1069534001205 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1069534001206 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1069534001207 Walker A/P-loop; other site 1069534001208 ATP binding site [chemical binding]; other site 1069534001209 Q-loop/lid; other site 1069534001210 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1069534001211 ABC transporter signature motif; other site 1069534001212 Walker B; other site 1069534001213 D-loop; other site 1069534001214 H-loop/switch region; other site 1069534001215 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1069534001216 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1069534001217 metal binding site 2 [ion binding]; metal-binding site 1069534001218 putative DNA binding helix; other site 1069534001219 metal binding site 1 [ion binding]; metal-binding site 1069534001220 dimer interface [polypeptide binding]; other site 1069534001221 structural Zn2+ binding site [ion binding]; other site 1069534001222 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1069534001223 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1069534001224 active site 1069534001225 HIGH motif; other site 1069534001226 dimer interface [polypeptide binding]; other site 1069534001227 KMSKS motif; other site 1069534001228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534001229 RNA binding surface [nucleotide binding]; other site 1069534001230 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1069534001231 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1069534001232 active site 1069534001233 dimer interface [polypeptide binding]; other site 1069534001234 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1069534001235 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1069534001236 active site 1069534001237 FMN binding site [chemical binding]; other site 1069534001238 substrate binding site [chemical binding]; other site 1069534001239 3Fe-4S cluster binding site [ion binding]; other site 1069534001240 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1069534001241 domain interface; other site 1069534001242 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1069534001243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1069534001244 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1069534001245 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 1069534001246 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534001247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534001248 non-specific DNA binding site [nucleotide binding]; other site 1069534001249 salt bridge; other site 1069534001250 sequence-specific DNA binding site [nucleotide binding]; other site 1069534001251 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1069534001252 Part of AAA domain; Region: AAA_19; pfam13245 1069534001253 Family description; Region: UvrD_C_2; pfam13538 1069534001254 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1069534001255 Cation efflux family; Region: Cation_efflux; pfam01545 1069534001256 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1069534001257 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1069534001258 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1069534001259 active site 1069534001260 HIGH motif; other site 1069534001261 dimer interface [polypeptide binding]; other site 1069534001262 KMSKS motif; other site 1069534001263 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1069534001264 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1069534001265 potential frameshift: common BLAST hit: gi|184153671|ref|YP_001842012.1| putative transposase 1069534001266 Transposase; Region: HTH_Tnp_1; cl17663 1069534001267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534001268 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534001269 Similar to Transposase; predicted to be non-functional due to Frameshifts 1069534001270 TraX protein; Region: TraX; cl05434 1069534001271 Similar to Transposase; predicted to be non-functional due to truncation 1069534001272 HTH-like domain; Region: HTH_21; pfam13276 1069534001273 Integrase core domain; Region: rve; pfam00665 1069534001274 Integrase core domain; Region: rve_3; cl15866 1069534001275 Similar to Geranyltransferase; predicted to be non-functional due to truncation 1069534001276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534001277 Transposase; Region: HTH_Tnp_1; cl17663 1069534001278 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534001279 HTH-like domain; Region: HTH_21; pfam13276 1069534001280 Integrase core domain; Region: rve; pfam00665 1069534001281 Integrase core domain; Region: rve_2; pfam13333 1069534001282 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1069534001283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534001284 substrate binding pocket [chemical binding]; other site 1069534001285 membrane-bound complex binding site; other site 1069534001286 hinge residues; other site 1069534001287 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1069534001288 homodimer interface [polypeptide binding]; other site 1069534001289 catalytic residues [active] 1069534001290 NAD binding site [chemical binding]; other site 1069534001291 substrate binding pocket [chemical binding]; other site 1069534001292 flexible flap; other site 1069534001293 NAD-dependent deacetylase; Provisional; Region: PRK00481 1069534001294 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1069534001295 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1069534001296 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1069534001297 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1069534001298 active site 1069534001299 HIGH motif; other site 1069534001300 KMSKS motif; other site 1069534001301 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1069534001302 tRNA binding surface [nucleotide binding]; other site 1069534001303 anticodon binding site; other site 1069534001304 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1069534001305 dimer interface [polypeptide binding]; other site 1069534001306 putative tRNA-binding site [nucleotide binding]; other site 1069534001307 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1069534001308 active site 1069534001309 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1069534001310 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1069534001311 putative active site [active] 1069534001312 putative metal binding site [ion binding]; other site 1069534001313 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1069534001314 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1069534001315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534001316 S-adenosylmethionine binding site [chemical binding]; other site 1069534001317 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1069534001318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1069534001319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1069534001320 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1069534001321 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1069534001322 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1069534001323 shikimate binding site; other site 1069534001324 NAD(P) binding site [chemical binding]; other site 1069534001325 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1069534001326 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1069534001327 active site 1069534001328 catalytic residue [active] 1069534001329 dimer interface [polypeptide binding]; other site 1069534001330 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1069534001331 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1069534001332 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1069534001333 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1069534001334 argininosuccinate lyase; Provisional; Region: PRK00855 1069534001335 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1069534001336 active sites [active] 1069534001337 tetramer interface [polypeptide binding]; other site 1069534001338 argininosuccinate synthase; Provisional; Region: PRK13820 1069534001339 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1069534001340 ANP binding site [chemical binding]; other site 1069534001341 Substrate Binding Site II [chemical binding]; other site 1069534001342 Substrate Binding Site I [chemical binding]; other site 1069534001343 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1069534001344 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1069534001345 Ca binding site [ion binding]; other site 1069534001346 active site 1069534001347 catalytic site [active] 1069534001348 pur operon repressor; Provisional; Region: PRK09213 1069534001349 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1069534001350 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534001351 active site 1069534001352 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1069534001353 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1069534001354 Substrate binding site; other site 1069534001355 Mg++ binding site; other site 1069534001356 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1069534001357 active site 1069534001358 substrate binding site [chemical binding]; other site 1069534001359 CoA binding site [chemical binding]; other site 1069534001360 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1069534001361 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1069534001362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534001363 active site 1069534001364 Similar to Transposase; predicted to be non-functional die to Frameshift 1069534001365 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534001367 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534001368 MULE transposase domain; Region: MULE; pfam10551 1069534001369 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1069534001370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534001371 Walker A/P-loop; other site 1069534001372 ATP binding site [chemical binding]; other site 1069534001373 Q-loop/lid; other site 1069534001374 ABC transporter signature motif; other site 1069534001375 Walker B; other site 1069534001376 D-loop; other site 1069534001377 H-loop/switch region; other site 1069534001378 ABC transporter; Region: ABC_tran_2; pfam12848 1069534001379 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001380 Similar to Biotin operon repressor; predicted to be nonfunctional due to frameshift 1069534001381 similar to Transposase; predicted to be non-functional due to truncation 1069534001382 Similar to Resolvase; predicted to be non-functional due to truncation 1069534001383 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1069534001384 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1069534001385 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1069534001386 YibE/F-like protein; Region: YibE_F; pfam07907 1069534001387 YibE/F-like protein; Region: YibE_F; pfam07907 1069534001388 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1069534001389 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1069534001390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534001391 Zn2+ binding site [ion binding]; other site 1069534001392 Mg2+ binding site [ion binding]; other site 1069534001393 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1069534001394 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1069534001395 Similar to CTP synthetase; predicted to ben non-functional due to Frameshift 1069534001396 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534001397 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1069534001398 Walker A/P-loop; other site 1069534001399 ATP binding site [chemical binding]; other site 1069534001400 Q-loop/lid; other site 1069534001401 ABC transporter signature motif; other site 1069534001402 Walker B; other site 1069534001403 D-loop; other site 1069534001404 H-loop/switch region; other site 1069534001405 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1069534001406 FtsX-like permease family; Region: FtsX; pfam02687 1069534001407 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1069534001408 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1069534001409 hinge; other site 1069534001410 active site 1069534001411 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1069534001412 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1069534001413 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1069534001414 RNA binding site [nucleotide binding]; other site 1069534001415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1069534001416 Walker A motif; other site 1069534001417 ATP binding site [chemical binding]; other site 1069534001418 Walker B motif; other site 1069534001419 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1069534001420 Similar to Heavy-metal transporting P-type ATPase; predicted to be non-functional due to Frameshift 1069534001421 Similar to Transcriptional regulator AraC family; predicted to be non-functional due to truncation 1069534001422 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1069534001423 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1069534001424 TPP-binding site [chemical binding]; other site 1069534001425 dimer interface [polypeptide binding]; other site 1069534001426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1069534001427 PYR/PP interface [polypeptide binding]; other site 1069534001428 dimer interface [polypeptide binding]; other site 1069534001429 TPP binding site [chemical binding]; other site 1069534001430 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 1069534001431 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1069534001432 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1069534001433 active site 1069534001434 dimer interface [polypeptide binding]; other site 1069534001435 metal binding site [ion binding]; metal-binding site 1069534001436 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534001437 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1069534001438 Walker A/P-loop; other site 1069534001439 ATP binding site [chemical binding]; other site 1069534001440 Q-loop/lid; other site 1069534001441 ABC transporter signature motif; other site 1069534001442 Walker B; other site 1069534001443 D-loop; other site 1069534001444 H-loop/switch region; other site 1069534001445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1069534001446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1069534001447 FtsX-like permease family; Region: FtsX; pfam02687 1069534001448 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1069534001449 putative deacylase active site [active] 1069534001450 Predicted membrane protein [Function unknown]; Region: COG4684 1069534001451 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1069534001452 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1069534001453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534001454 active site 1069534001455 xanthine permease; Region: pbuX; TIGR03173 1069534001456 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1069534001457 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 1069534001458 NAD binding site [chemical binding]; other site 1069534001459 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1069534001460 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534001461 MULE transposase domain; Region: MULE; pfam10551 1069534001462 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1069534001463 Part of AAA domain; Region: AAA_19; pfam13245 1069534001464 Family description; Region: UvrD_C_2; pfam13538 1069534001465 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1069534001466 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1069534001467 nucleotide binding pocket [chemical binding]; other site 1069534001468 K-X-D-G motif; other site 1069534001469 catalytic site [active] 1069534001470 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1069534001471 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1069534001472 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1069534001473 Dimer interface [polypeptide binding]; other site 1069534001474 BRCT sequence motif; other site 1069534001475 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1069534001476 putative dimer interface [polypeptide binding]; other site 1069534001477 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1069534001478 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1069534001479 putative dimer interface [polypeptide binding]; other site 1069534001480 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1069534001481 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1069534001482 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1069534001483 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1069534001484 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1069534001485 GatB domain; Region: GatB_Yqey; smart00845 1069534001486 putative lipid kinase; Reviewed; Region: PRK13055 1069534001487 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1069534001488 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1069534001489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1069534001490 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1069534001491 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1069534001492 metal-binding site [ion binding] 1069534001493 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1069534001494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1069534001495 ligand binding site [chemical binding]; other site 1069534001496 flexible hinge region; other site 1069534001497 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1069534001498 DinB superfamily; Region: DinB_2; pfam12867 1069534001499 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1069534001500 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1069534001501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534001502 S-adenosylmethionine binding site [chemical binding]; other site 1069534001503 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1069534001504 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1069534001505 catalytic residues [active] 1069534001506 catalytic nucleophile [active] 1069534001507 Recombinase; Region: Recombinase; pfam07508 1069534001508 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1069534001509 Recombinase; Region: Recombinase; pfam07508 1069534001510 Recombinase; Region: Recombinase; pfam07508 1069534001511 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1069534001512 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 1069534001513 Similar to Recombinase; predicted to be non-functional due to an In frame stop codon and frameshift 1069534001514 Similar to DNA (cytosine-5-)-methyltransferase; predicted to be non-functional due to frameshift 1069534001515 transposase/IS protein; Provisional; Region: PRK09183 1069534001516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534001517 Walker A motif; other site 1069534001518 ATP binding site [chemical binding]; other site 1069534001519 Walker B motif; other site 1069534001520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1069534001521 Integrase core domain; Region: rve; pfam00665 1069534001522 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 1069534001523 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 1069534001524 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1069534001525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534001526 ATP binding site [chemical binding]; other site 1069534001527 putative Mg++ binding site [ion binding]; other site 1069534001528 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1069534001529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001530 nucleotide binding region [chemical binding]; other site 1069534001531 ATP-binding site [chemical binding]; other site 1069534001532 Quinolinate synthetase A protein; Region: NadA; pfam02445 1069534001533 L-aspartate oxidase; Provisional; Region: PRK06175 1069534001534 FAD binding domain; Region: FAD_binding_2; pfam00890 1069534001535 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1069534001536 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1069534001537 dimerization interface [polypeptide binding]; other site 1069534001538 active site 1069534001539 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1069534001540 HTH domain; Region: HTH_11; pfam08279 1069534001541 3H domain; Region: 3H; pfam02829 1069534001542 Similar to Restriction enzyme BgcI subunit alpha; predicted to be non-functional due to an In frame stop codon 1069534001543 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1069534001544 Similar to TypeIIs restriction enzyme protein; non-functional due to truncation 1069534001545 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1069534001546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534001547 non-specific DNA binding site [nucleotide binding]; other site 1069534001548 salt bridge; other site 1069534001549 sequence-specific DNA binding site [nucleotide binding]; other site 1069534001550 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1069534001551 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1069534001552 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1069534001553 active site 1069534001554 Protein of unknown function (DUF975); Region: DUF975; cl10504 1069534001555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534001556 salt bridge; other site 1069534001557 non-specific DNA binding site [nucleotide binding]; other site 1069534001558 sequence-specific DNA binding site [nucleotide binding]; other site 1069534001559 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1069534001560 Flagellin N-methylase; Region: FliB; pfam03692 1069534001561 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1069534001562 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1069534001563 putative active site [active] 1069534001564 catalytic site [active] 1069534001565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534001566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534001567 putative substrate translocation pore; other site 1069534001568 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1069534001569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1069534001570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534001571 active site 1069534001572 motif I; other site 1069534001573 motif II; other site 1069534001574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1069534001575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534001576 Coenzyme A binding pocket [chemical binding]; other site 1069534001577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1069534001578 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1069534001579 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1069534001580 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1069534001581 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1069534001582 proposed active site lysine [active] 1069534001583 conserved cys residue [active] 1069534001584 similar to MATE efflux family protein; predicted to be nofunctional due to frameshift 1069534001585 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1069534001586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534001587 Coenzyme A binding pocket [chemical binding]; other site 1069534001588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1069534001589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534001590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534001591 putative substrate translocation pore; other site 1069534001592 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1069534001593 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1069534001594 catalytic Zn binding site [ion binding]; other site 1069534001595 NAD(P) binding site [chemical binding]; other site 1069534001596 structural Zn binding site [ion binding]; other site 1069534001597 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1069534001598 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1069534001599 HNH endonuclease; Region: HNH; pfam01844 1069534001600 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1069534001601 active site 1069534001602 8-oxo-dGMP binding site [chemical binding]; other site 1069534001603 nudix motif; other site 1069534001604 metal binding site [ion binding]; metal-binding site 1069534001605 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1069534001606 PLD-like domain; Region: PLDc_2; pfam13091 1069534001607 putative homodimer interface [polypeptide binding]; other site 1069534001608 putative active site [active] 1069534001609 catalytic site [active] 1069534001610 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1069534001611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534001612 ATP binding site [chemical binding]; other site 1069534001613 putative Mg++ binding site [ion binding]; other site 1069534001614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001615 nucleotide binding region [chemical binding]; other site 1069534001616 ATP-binding site [chemical binding]; other site 1069534001617 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1069534001618 hypothetical protein; Provisional; Region: PRK11770 1069534001619 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1069534001620 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1069534001621 H+ Antiporter protein; Region: 2A0121; TIGR00900 1069534001622 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1069534001623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001624 ABC transporter; Region: ABC_tran_2; pfam12848 1069534001625 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1069534001626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001627 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1069534001628 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1069534001629 G1 box; other site 1069534001630 GTP/Mg2+ binding site [chemical binding]; other site 1069534001631 G2 box; other site 1069534001632 Switch I region; other site 1069534001633 G3 box; other site 1069534001634 Switch II region; other site 1069534001635 G4 box; other site 1069534001636 G5 box; other site 1069534001637 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1069534001638 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1069534001639 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1069534001640 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1069534001641 trimer interface [polypeptide binding]; other site 1069534001642 active site 1069534001643 substrate binding site [chemical binding]; other site 1069534001644 CoA binding site [chemical binding]; other site 1069534001645 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1069534001646 CHY zinc finger; Region: zf-CHY; pfam05495 1069534001647 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1069534001648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534001649 Transposase; Region: HTH_Tnp_1; cl17663 1069534001650 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534001651 HTH-like domain; Region: HTH_21; pfam13276 1069534001652 Integrase core domain; Region: rve; pfam00665 1069534001653 Integrase core domain; Region: rve_2; pfam13333 1069534001654 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1069534001655 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1069534001656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1069534001657 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1069534001658 ATP binding site [chemical binding]; other site 1069534001659 putative Mg++ binding site [ion binding]; other site 1069534001660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001661 nucleotide binding region [chemical binding]; other site 1069534001662 ATP-binding site [chemical binding]; other site 1069534001663 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1069534001664 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1069534001665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534001666 S-adenosylmethionine binding site [chemical binding]; other site 1069534001667 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1069534001668 nucleoside/Zn binding site; other site 1069534001669 dimer interface [polypeptide binding]; other site 1069534001670 catalytic motif [active] 1069534001671 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1069534001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534001673 Walker A motif; other site 1069534001674 ATP binding site [chemical binding]; other site 1069534001675 Walker B motif; other site 1069534001676 arginine finger; other site 1069534001677 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1069534001678 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1069534001679 hypothetical protein; Validated; Region: PRK00153 1069534001680 recombination protein RecR; Reviewed; Region: recR; PRK00076 1069534001681 RecR protein; Region: RecR; pfam02132 1069534001682 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1069534001683 putative active site [active] 1069534001684 putative metal-binding site [ion binding]; other site 1069534001685 tetramer interface [polypeptide binding]; other site 1069534001686 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1069534001687 thymidylate kinase; Validated; Region: tmk; PRK00698 1069534001688 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1069534001689 TMP-binding site; other site 1069534001690 ATP-binding site [chemical binding]; other site 1069534001691 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1069534001692 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1069534001693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534001694 Walker A motif; other site 1069534001695 ATP binding site [chemical binding]; other site 1069534001696 Walker B motif; other site 1069534001697 arginine finger; other site 1069534001698 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1069534001699 Predicted methyltransferases [General function prediction only]; Region: COG0313 1069534001700 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1069534001701 putative SAM binding site [chemical binding]; other site 1069534001702 putative homodimer interface [polypeptide binding]; other site 1069534001703 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1069534001704 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1069534001705 active site 1069534001706 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1069534001707 aconitate hydratase; Validated; Region: PRK09277 1069534001708 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1069534001709 substrate binding site [chemical binding]; other site 1069534001710 ligand binding site [chemical binding]; other site 1069534001711 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1069534001712 substrate binding site [chemical binding]; other site 1069534001713 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1069534001714 Citrate synthase; Region: Citrate_synt; pfam00285 1069534001715 oxalacetate binding site [chemical binding]; other site 1069534001716 citrylCoA binding site [chemical binding]; other site 1069534001717 coenzyme A binding site [chemical binding]; other site 1069534001718 catalytic triad [active] 1069534001719 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1069534001720 isocitrate dehydrogenase; Validated; Region: PRK07362 1069534001721 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1069534001722 Glycoprotease family; Region: Peptidase_M22; pfam00814 1069534001723 Similar to Acetyltransferase; predicted to be non-functional due to frameshift 1069534001724 UGMP family protein; Validated; Region: PRK09604 1069534001725 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1069534001726 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1069534001727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001729 ABC transporter; Region: ABC_tran_2; pfam12848 1069534001730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534001731 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1069534001732 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1069534001733 CoA binding domain; Region: CoA_binding; pfam02629 1069534001734 CAAX protease self-immunity; Region: Abi; pfam02517 1069534001735 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1069534001736 oligomerisation interface [polypeptide binding]; other site 1069534001737 mobile loop; other site 1069534001738 roof hairpin; other site 1069534001739 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1069534001740 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1069534001741 ring oligomerisation interface [polypeptide binding]; other site 1069534001742 ATP/Mg binding site [chemical binding]; other site 1069534001743 stacking interactions; other site 1069534001744 hinge regions; other site 1069534001745 Amino acid permease; Region: AA_permease_2; pfam13520 1069534001746 K+ potassium transporter; Region: K_trans; cl15781 1069534001747 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1069534001748 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1069534001749 Mg++ binding site [ion binding]; other site 1069534001750 putative catalytic motif [active] 1069534001751 substrate binding site [chemical binding]; other site 1069534001752 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1069534001753 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1069534001754 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1069534001755 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1069534001756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534001757 ATP binding site [chemical binding]; other site 1069534001758 putative Mg++ binding site [ion binding]; other site 1069534001759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001760 nucleotide binding region [chemical binding]; other site 1069534001761 ATP-binding site [chemical binding]; other site 1069534001762 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1069534001763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534001764 active site 1069534001765 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1069534001766 30S subunit binding site; other site 1069534001767 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1069534001768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1069534001769 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1069534001770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001771 nucleotide binding region [chemical binding]; other site 1069534001772 ATP-binding site [chemical binding]; other site 1069534001773 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1069534001774 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1069534001775 RF-1 domain; Region: RF-1; pfam00472 1069534001776 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1069534001777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534001778 Walker A/P-loop; other site 1069534001779 ATP binding site [chemical binding]; other site 1069534001780 Q-loop/lid; other site 1069534001781 ABC transporter signature motif; other site 1069534001782 Walker B; other site 1069534001783 D-loop; other site 1069534001784 H-loop/switch region; other site 1069534001785 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1069534001786 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1069534001787 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1069534001788 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1069534001789 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1069534001790 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1069534001791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534001793 active site 1069534001794 phosphorylation site [posttranslational modification] 1069534001795 intermolecular recognition site; other site 1069534001796 dimerization interface [polypeptide binding]; other site 1069534001797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534001798 DNA binding site [nucleotide binding] 1069534001799 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1069534001800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1069534001801 dimer interface [polypeptide binding]; other site 1069534001802 phosphorylation site [posttranslational modification] 1069534001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534001804 ATP binding site [chemical binding]; other site 1069534001805 Mg2+ binding site [ion binding]; other site 1069534001806 G-X-G motif; other site 1069534001807 PspC domain; Region: PspC; pfam04024 1069534001808 Predicted membrane protein [Function unknown]; Region: COG1950 1069534001809 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1069534001810 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1069534001811 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1069534001812 Hpr binding site; other site 1069534001813 active site 1069534001814 homohexamer subunit interaction site [polypeptide binding]; other site 1069534001815 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1069534001816 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1069534001817 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1069534001818 active site 1069534001819 substrate binding site [chemical binding]; other site 1069534001820 metal binding site [ion binding]; metal-binding site 1069534001821 excinuclease ABC subunit B; Provisional; Region: PRK05298 1069534001822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534001823 ATP binding site [chemical binding]; other site 1069534001824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534001825 nucleotide binding region [chemical binding]; other site 1069534001826 ATP-binding site [chemical binding]; other site 1069534001827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1069534001828 UvrB/uvrC motif; Region: UVR; pfam02151 1069534001829 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1069534001830 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1069534001831 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1069534001832 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1069534001833 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1069534001834 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1069534001835 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1069534001836 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1069534001837 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1069534001838 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1069534001839 AAA domain; Region: AAA_33; pfam13671 1069534001840 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1069534001841 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1069534001842 phosphate binding site [ion binding]; other site 1069534001843 putative substrate binding pocket [chemical binding]; other site 1069534001844 dimer interface [polypeptide binding]; other site 1069534001845 Similar to Conserved hypothetical protein; predicted to be non-functional due to frameshift 1069534001846 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1069534001847 similar to Transposase; predicted to be non-functional due to truncation 1069534001848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534001849 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1069534001850 Walker A/P-loop; other site 1069534001851 ATP binding site [chemical binding]; other site 1069534001852 Q-loop/lid; other site 1069534001853 ABC transporter signature motif; other site 1069534001854 Walker B; other site 1069534001855 D-loop; other site 1069534001856 H-loop/switch region; other site 1069534001857 Clp protease; Region: CLP_protease; pfam00574 1069534001858 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1069534001859 oligomer interface [polypeptide binding]; other site 1069534001860 active site residues [active] 1069534001861 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1069534001862 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1069534001863 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1069534001864 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1069534001865 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1069534001866 Predicted transcriptional regulator [Transcription]; Region: COG3388 1069534001867 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1069534001868 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1069534001869 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1069534001870 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1069534001871 Phosphoglycerate kinase; Region: PGK; pfam00162 1069534001872 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1069534001873 substrate binding site [chemical binding]; other site 1069534001874 hinge regions; other site 1069534001875 ADP binding site [chemical binding]; other site 1069534001876 catalytic site [active] 1069534001877 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1069534001878 triosephosphate isomerase; Provisional; Region: PRK14567 1069534001879 substrate binding site [chemical binding]; other site 1069534001880 dimer interface [polypeptide binding]; other site 1069534001881 catalytic triad [active] 1069534001882 enolase; Provisional; Region: eno; PRK00077 1069534001883 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1069534001884 dimer interface [polypeptide binding]; other site 1069534001885 metal binding site [ion binding]; metal-binding site 1069534001886 substrate binding pocket [chemical binding]; other site 1069534001887 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1069534001888 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1069534001889 Cl- selectivity filter; other site 1069534001890 Cl- binding residues [ion binding]; other site 1069534001891 pore gating glutamate residue; other site 1069534001892 dimer interface [polypeptide binding]; other site 1069534001893 H+/Cl- coupling transport residue; other site 1069534001894 TrkA-C domain; Region: TrkA_C; pfam02080 1069534001895 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1069534001896 ribonuclease R; Region: RNase_R; TIGR02063 1069534001897 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1069534001898 RNB domain; Region: RNB; pfam00773 1069534001899 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1069534001900 RNA binding site [nucleotide binding]; other site 1069534001901 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1069534001902 SmpB-tmRNA interface; other site 1069534001903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1069534001904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534001905 Coenzyme A binding pocket [chemical binding]; other site 1069534001906 Tubby C 2; Region: Tub_2; cl02043 1069534001907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534001908 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1069534001909 active site 1069534001910 motif I; other site 1069534001911 motif II; other site 1069534001912 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1069534001913 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1069534001914 ligand binding site [chemical binding]; other site 1069534001915 active site 1069534001916 UGI interface [polypeptide binding]; other site 1069534001917 catalytic site [active] 1069534001918 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1069534001919 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1069534001920 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1069534001921 active site 1069534001922 catalytic site [active] 1069534001923 substrate binding site [chemical binding]; other site 1069534001924 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1069534001925 active site 1069534001926 putative catalytic site [active] 1069534001927 DNA binding site [nucleotide binding] 1069534001928 putative phosphate binding site [ion binding]; other site 1069534001929 metal binding site A [ion binding]; metal-binding site 1069534001930 AP binding site [nucleotide binding]; other site 1069534001931 metal binding site B [ion binding]; metal-binding site 1069534001932 histidinol-phosphatase; Reviewed; Region: PRK08123 1069534001933 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1069534001934 active site 1069534001935 dimer interface [polypeptide binding]; other site 1069534001936 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1069534001937 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1069534001938 dimer interface [polypeptide binding]; other site 1069534001939 motif 1; other site 1069534001940 active site 1069534001941 motif 2; other site 1069534001942 motif 3; other site 1069534001943 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1069534001944 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1069534001945 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1069534001946 histidinol dehydrogenase; Region: hisD; TIGR00069 1069534001947 NAD binding site [chemical binding]; other site 1069534001948 dimerization interface [polypeptide binding]; other site 1069534001949 product binding site; other site 1069534001950 substrate binding site [chemical binding]; other site 1069534001951 zinc binding site [ion binding]; other site 1069534001952 catalytic residues [active] 1069534001953 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1069534001954 putative active site pocket [active] 1069534001955 4-fold oligomerization interface [polypeptide binding]; other site 1069534001956 metal binding residues [ion binding]; metal-binding site 1069534001957 3-fold/trimer interface [polypeptide binding]; other site 1069534001958 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1069534001959 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1069534001960 putative active site [active] 1069534001961 oxyanion strand; other site 1069534001962 catalytic triad [active] 1069534001963 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1069534001964 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1069534001965 catalytic residues [active] 1069534001966 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1069534001967 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1069534001968 substrate binding site [chemical binding]; other site 1069534001969 glutamase interaction surface [polypeptide binding]; other site 1069534001970 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1069534001971 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1069534001972 metal binding site [ion binding]; metal-binding site 1069534001973 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1069534001974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534001975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534001976 homodimer interface [polypeptide binding]; other site 1069534001977 catalytic residue [active] 1069534001978 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1069534001979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534001980 Coenzyme A binding pocket [chemical binding]; other site 1069534001981 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1069534001982 FAD binding domain; Region: FAD_binding_4; pfam01565 1069534001983 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1069534001984 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1069534001985 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1069534001986 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1069534001987 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1069534001988 active site 1069534001989 homodimer interface [polypeptide binding]; other site 1069534001990 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1069534001991 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1069534001992 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1069534001993 active site 1069534001994 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1069534001995 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1069534001996 active site 1069534001997 tetramer interface; other site 1069534001998 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534001999 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1069534002000 RecX family; Region: RecX; cl00936 1069534002001 Similar to Transposase; predicted to be non-functional due to frameshift 1069534002002 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1069534002003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534002004 S-adenosylmethionine binding site [chemical binding]; other site 1069534002005 hypothetical protein; Provisional; Region: PRK13662 1069534002006 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1069534002007 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1069534002008 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1069534002009 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1069534002010 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1069534002011 Similar to GtcA family membrane protein; predicted to be non-functional due to truncation 1069534002012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534002013 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1069534002014 Walker A/P-loop; other site 1069534002015 ATP binding site [chemical binding]; other site 1069534002016 Q-loop/lid; other site 1069534002017 ABC transporter signature motif; other site 1069534002018 Walker B; other site 1069534002019 D-loop; other site 1069534002020 H-loop/switch region; other site 1069534002021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534002022 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1069534002023 Domain of unknown function DUF21; Region: DUF21; pfam01595 1069534002024 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1069534002025 Transporter associated domain; Region: CorC_HlyC; smart01091 1069534002026 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1069534002027 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1069534002028 G1 box; other site 1069534002029 putative GEF interaction site [polypeptide binding]; other site 1069534002030 GTP/Mg2+ binding site [chemical binding]; other site 1069534002031 Switch I region; other site 1069534002032 G2 box; other site 1069534002033 G3 box; other site 1069534002034 Switch II region; other site 1069534002035 G4 box; other site 1069534002036 G5 box; other site 1069534002037 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1069534002038 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1069534002039 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1069534002040 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1069534002041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534002042 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1069534002043 Walker A motif; other site 1069534002044 ATP binding site [chemical binding]; other site 1069534002045 Walker B motif; other site 1069534002046 arginine finger; other site 1069534002047 UvrB/uvrC motif; Region: UVR; pfam02151 1069534002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534002049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1069534002050 Walker A motif; other site 1069534002051 ATP binding site [chemical binding]; other site 1069534002052 Walker B motif; other site 1069534002053 arginine finger; other site 1069534002054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1069534002055 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1069534002056 dimerization domain swap beta strand [polypeptide binding]; other site 1069534002057 regulatory protein interface [polypeptide binding]; other site 1069534002058 active site 1069534002059 regulatory phosphorylation site [posttranslational modification]; other site 1069534002060 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1069534002061 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1069534002062 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1069534002063 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1069534002064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1069534002065 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1069534002066 putative ADP-binding pocket [chemical binding]; other site 1069534002067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1069534002068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1069534002069 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1069534002070 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1069534002071 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1069534002072 Sulfatase; Region: Sulfatase; pfam00884 1069534002073 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534002074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534002075 Similar to Transposase; predicted to be non-functional due to frameshift 1069534002076 integrase; Provisional; Region: int; PHA02601 1069534002077 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1069534002078 Int/Topo IB signature motif; other site 1069534002079 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1069534002080 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1069534002081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534002082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534002083 non-specific DNA binding site [nucleotide binding]; other site 1069534002084 salt bridge; other site 1069534002085 sequence-specific DNA binding site [nucleotide binding]; other site 1069534002086 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1069534002087 Prophage antirepressor [Transcription]; Region: COG3617 1069534002088 BRO family, N-terminal domain; Region: Bro-N; smart01040 1069534002089 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1069534002090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534002091 non-specific DNA binding site [nucleotide binding]; other site 1069534002092 salt bridge; other site 1069534002093 sequence-specific DNA binding site [nucleotide binding]; other site 1069534002094 Domain of unknown function (DUF771); Region: DUF771; cl09962 1069534002095 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1069534002096 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1069534002097 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1069534002098 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1069534002099 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1069534002100 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1069534002101 active site 1069534002102 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1069534002103 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1069534002104 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1069534002105 Phage capsid family; Region: Phage_capsid; pfam05065 1069534002106 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 1069534002107 Phage-related protein [Function unknown]; Region: COG5412 1069534002108 Phage tail protein; Region: Sipho_tail; cl17486 1069534002109 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1069534002110 Holin family; Region: Phage_holin_4; pfam05105 1069534002111 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1069534002112 active site 1069534002113 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1069534002114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534002115 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1069534002116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534002117 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534002118 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1069534002119 Similar to Phage-related membrane protein; predicted to be non-functional due to truncation 1069534002120 similar to Transposase; predicted to be non-functional due to Frameshift 1069534002121 galactokinase; Provisional; Region: PRK05322 1069534002122 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1069534002123 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1069534002124 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1069534002125 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1069534002126 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1069534002127 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1069534002128 FeoA domain; Region: FeoA; pfam04023 1069534002129 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1069534002130 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1069534002131 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1069534002132 G1 box; other site 1069534002133 GTP/Mg2+ binding site [chemical binding]; other site 1069534002134 Switch I region; other site 1069534002135 G2 box; other site 1069534002136 G3 box; other site 1069534002137 Switch II region; other site 1069534002138 G4 box; other site 1069534002139 G5 box; other site 1069534002140 Nucleoside recognition; Region: Gate; pfam07670 1069534002141 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1069534002142 Nucleoside recognition; Region: Gate; pfam07670 1069534002143 Virus attachment protein p12 family; Region: P12; pfam12669 1069534002144 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1069534002145 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1069534002146 hypothetical protein; Provisional; Region: PRK13690 1069534002147 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1069534002148 ATP cone domain; Region: ATP-cone; pfam03477 1069534002149 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1069534002150 effector binding site; other site 1069534002151 active site 1069534002152 Zn binding site [ion binding]; other site 1069534002153 glycine loop; other site 1069534002154 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1069534002155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1069534002156 FeS/SAM binding site; other site 1069534002157 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1069534002158 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1069534002159 ArsC family; Region: ArsC; pfam03960 1069534002160 putative catalytic residues [active] 1069534002161 thiol/disulfide switch; other site 1069534002162 adaptor protein; Provisional; Region: PRK02315 1069534002163 Competence protein CoiA-like family; Region: CoiA; cl11541 1069534002164 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1069534002165 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1069534002166 active site 1069534002167 Zn binding site [ion binding]; other site 1069534002168 Thioredoxin; Region: Thioredoxin_5; pfam13743 1069534002169 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1069534002170 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1069534002171 synthetase active site [active] 1069534002172 NTP binding site [chemical binding]; other site 1069534002173 metal binding site [ion binding]; metal-binding site 1069534002174 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1069534002175 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1069534002176 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1069534002177 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1069534002178 active site 1069534002179 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1069534002180 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1069534002181 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1069534002182 Divalent cation transporter; Region: MgtE; pfam01769 1069534002183 Similar to Conserved hypothetical protein; predicted to be non-functional due to Frameshift 1069534002184 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1069534002185 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1069534002186 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1069534002187 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1069534002188 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1069534002189 active site 1069534002190 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1069534002191 putative deacylase active site [active] 1069534002192 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1069534002193 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1069534002194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1069534002195 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1069534002196 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1069534002197 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1069534002198 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1069534002199 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1069534002200 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1069534002201 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1069534002202 classical (c) SDRs; Region: SDR_c; cd05233 1069534002203 NAD(P) binding site [chemical binding]; other site 1069534002204 active site 1069534002205 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1069534002206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534002207 non-specific DNA binding site [nucleotide binding]; other site 1069534002208 salt bridge; other site 1069534002209 sequence-specific DNA binding site [nucleotide binding]; other site 1069534002210 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1069534002211 competence damage-inducible protein A; Provisional; Region: PRK00549 1069534002212 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1069534002213 putative MPT binding site; other site 1069534002214 Competence-damaged protein; Region: CinA; pfam02464 1069534002215 recombinase A; Provisional; Region: recA; PRK09354 1069534002216 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1069534002217 hexamer interface [polypeptide binding]; other site 1069534002218 Walker A motif; other site 1069534002219 ATP binding site [chemical binding]; other site 1069534002220 Walker B motif; other site 1069534002221 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1069534002222 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1069534002223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534002224 Zn2+ binding site [ion binding]; other site 1069534002225 Mg2+ binding site [ion binding]; other site 1069534002226 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1069534002227 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1069534002228 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1069534002229 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1069534002230 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1069534002231 glutamine binding [chemical binding]; other site 1069534002232 catalytic triad [active] 1069534002233 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1069534002234 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1069534002235 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1069534002236 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1069534002237 active site 1069534002238 ribulose/triose binding site [chemical binding]; other site 1069534002239 phosphate binding site [ion binding]; other site 1069534002240 substrate (anthranilate) binding pocket [chemical binding]; other site 1069534002241 product (indole) binding pocket [chemical binding]; other site 1069534002242 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1069534002243 active site 1069534002244 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1069534002245 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1069534002246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534002247 catalytic residue [active] 1069534002248 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1069534002249 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1069534002250 substrate binding site [chemical binding]; other site 1069534002251 active site 1069534002252 catalytic residues [active] 1069534002253 heterodimer interface [polypeptide binding]; other site 1069534002254 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1069534002255 active site 1069534002256 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1069534002257 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1069534002258 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1069534002259 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534002260 MULE transposase domain; Region: MULE; pfam10551 1069534002261 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1069534002262 HTH-like domain; Region: HTH_21; pfam13276 1069534002263 Integrase core domain; Region: rve; pfam00665 1069534002264 Integrase core domain; Region: rve_3; cl15866 1069534002265 Transposase; Region: HTH_Tnp_1; cl17663 1069534002266 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534002267 DNA primase; Validated; Region: dnaG; PRK05667 1069534002268 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1069534002269 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1069534002270 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1069534002271 active site 1069534002272 metal binding site [ion binding]; metal-binding site 1069534002273 interdomain interaction site; other site 1069534002274 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1069534002275 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1069534002276 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1069534002277 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1069534002278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1069534002279 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1069534002280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1069534002281 DNA binding residues [nucleotide binding] 1069534002282 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534002284 DNA-binding site [nucleotide binding]; DNA binding site 1069534002285 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534002286 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1069534002287 D-lactate dehydrogenase; Validated; Region: PRK08605 1069534002288 homodimer interface [polypeptide binding]; other site 1069534002289 ligand binding site [chemical binding]; other site 1069534002290 NAD binding site [chemical binding]; other site 1069534002291 catalytic site [active] 1069534002292 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1069534002293 rRNA interaction site [nucleotide binding]; other site 1069534002294 S8 interaction site; other site 1069534002295 putative laminin-1 binding site; other site 1069534002296 elongation factor Ts; Provisional; Region: tsf; PRK09377 1069534002297 UBA/TS-N domain; Region: UBA; pfam00627 1069534002298 Elongation factor TS; Region: EF_TS; pfam00889 1069534002299 Elongation factor TS; Region: EF_TS; pfam00889 1069534002300 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1069534002301 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1069534002302 active site 1069534002303 ADP/pyrophosphate binding site [chemical binding]; other site 1069534002304 dimerization interface [polypeptide binding]; other site 1069534002305 allosteric effector site; other site 1069534002306 fructose-1,6-bisphosphate binding site; other site 1069534002307 pyruvate kinase; Provisional; Region: PRK06354 1069534002308 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1069534002309 domain interfaces; other site 1069534002310 active site 1069534002311 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1069534002312 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1069534002313 PLD-like domain; Region: PLDc_2; pfam13091 1069534002314 homodimer interface [polypeptide binding]; other site 1069534002315 putative active site [active] 1069534002316 catalytic site [active] 1069534002317 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1069534002318 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1069534002319 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1069534002320 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1069534002321 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1069534002322 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1069534002323 putative ligand binding site [chemical binding]; other site 1069534002324 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534002325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534002326 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1069534002327 Probable transposase; Region: OrfB_IS605; pfam01385 1069534002328 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534002329 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1069534002330 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1069534002331 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1069534002332 active site 1069534002333 elongation factor P; Validated; Region: PRK00529 1069534002334 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1069534002335 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1069534002336 RNA binding site [nucleotide binding]; other site 1069534002337 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1069534002338 RNA binding site [nucleotide binding]; other site 1069534002339 Asp23 family; Region: Asp23; pfam03780 1069534002340 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1069534002341 putative RNA binding site [nucleotide binding]; other site 1069534002342 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1069534002343 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1069534002344 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1069534002345 homodimer interface [polypeptide binding]; other site 1069534002346 NADP binding site [chemical binding]; other site 1069534002347 substrate binding site [chemical binding]; other site 1069534002348 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1069534002349 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1069534002350 generic binding surface II; other site 1069534002351 generic binding surface I; other site 1069534002352 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1069534002353 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1069534002354 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1069534002355 substrate binding pocket [chemical binding]; other site 1069534002356 chain length determination region; other site 1069534002357 substrate-Mg2+ binding site; other site 1069534002358 catalytic residues [active] 1069534002359 aspartate-rich region 1; other site 1069534002360 active site lid residues [active] 1069534002361 aspartate-rich region 2; other site 1069534002362 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1069534002363 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534002364 RNA binding surface [nucleotide binding]; other site 1069534002365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534002366 S-adenosylmethionine binding site [chemical binding]; other site 1069534002367 arginine repressor; Region: argR_whole; TIGR01529 1069534002368 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1069534002369 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1069534002370 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1069534002371 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1069534002372 Walker A/P-loop; other site 1069534002373 ATP binding site [chemical binding]; other site 1069534002374 Q-loop/lid; other site 1069534002375 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1069534002376 ABC transporter signature motif; other site 1069534002377 Walker B; other site 1069534002378 D-loop; other site 1069534002379 H-loop/switch region; other site 1069534002380 LexA repressor; Validated; Region: PRK00215 1069534002381 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1069534002382 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1069534002383 Catalytic site [active] 1069534002384 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1069534002385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1069534002386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534002387 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1069534002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534002389 Walker A/P-loop; other site 1069534002390 ATP binding site [chemical binding]; other site 1069534002391 Q-loop/lid; other site 1069534002392 ABC transporter signature motif; other site 1069534002393 Walker B; other site 1069534002394 D-loop; other site 1069534002395 H-loop/switch region; other site 1069534002396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534002397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534002398 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1069534002399 Walker A/P-loop; other site 1069534002400 ATP binding site [chemical binding]; other site 1069534002401 Q-loop/lid; other site 1069534002402 ABC transporter signature motif; other site 1069534002403 Walker B; other site 1069534002404 D-loop; other site 1069534002405 H-loop/switch region; other site 1069534002406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534002407 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534002408 HTH-like domain; Region: HTH_21; pfam13276 1069534002409 Integrase core domain; Region: rve; pfam00665 1069534002410 Integrase core domain; Region: rve_2; pfam13333 1069534002411 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1069534002412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1069534002413 putative acyl-acceptor binding pocket; other site 1069534002414 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1069534002415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534002416 S-adenosylmethionine binding site [chemical binding]; other site 1069534002417 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1069534002418 GIY-YIG motif/motif A; other site 1069534002419 putative active site [active] 1069534002420 putative metal binding site [ion binding]; other site 1069534002421 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1069534002422 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1069534002423 dimer interface [polypeptide binding]; other site 1069534002424 motif 1; other site 1069534002425 active site 1069534002426 motif 2; other site 1069534002427 motif 3; other site 1069534002428 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1069534002429 anticodon binding site; other site 1069534002430 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1069534002431 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1069534002432 dimer interface [polypeptide binding]; other site 1069534002433 anticodon binding site; other site 1069534002434 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1069534002435 homodimer interface [polypeptide binding]; other site 1069534002436 motif 1; other site 1069534002437 active site 1069534002438 motif 2; other site 1069534002439 GAD domain; Region: GAD; pfam02938 1069534002440 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1069534002441 motif 3; other site 1069534002442 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1069534002443 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1069534002444 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1069534002445 active site 1069534002446 metal binding site [ion binding]; metal-binding site 1069534002447 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534002448 catalytic core [active] 1069534002449 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534002450 MULE transposase domain; Region: MULE; pfam10551 1069534002451 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1069534002452 putative nucleotide binding site [chemical binding]; other site 1069534002453 uridine monophosphate binding site [chemical binding]; other site 1069534002454 homohexameric interface [polypeptide binding]; other site 1069534002455 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1069534002456 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1069534002457 hinge region; other site 1069534002458 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1069534002459 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1069534002460 catalytic residue [active] 1069534002461 putative FPP diphosphate binding site; other site 1069534002462 putative FPP binding hydrophobic cleft; other site 1069534002463 dimer interface [polypeptide binding]; other site 1069534002464 putative IPP diphosphate binding site; other site 1069534002465 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1069534002466 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1069534002467 RIP metalloprotease RseP; Region: TIGR00054 1069534002468 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1069534002469 active site 1069534002470 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1069534002471 protein binding site [polypeptide binding]; other site 1069534002472 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1069534002473 putative substrate binding region [chemical binding]; other site 1069534002474 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1069534002475 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1069534002476 dimer interface [polypeptide binding]; other site 1069534002477 motif 1; other site 1069534002478 active site 1069534002479 motif 2; other site 1069534002480 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1069534002481 putative deacylase active site [active] 1069534002482 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1069534002483 active site 1069534002484 motif 3; other site 1069534002485 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1069534002486 anticodon binding site; other site 1069534002487 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1069534002488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534002489 Coenzyme A binding pocket [chemical binding]; other site 1069534002490 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1069534002491 predicted active site [active] 1069534002492 catalytic triad [active] 1069534002493 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1069534002494 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1069534002495 active site 1069534002496 multimer interface [polypeptide binding]; other site 1069534002497 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1069534002498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534002499 DNA-binding site [nucleotide binding]; DNA binding site 1069534002500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534002501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534002502 homodimer interface [polypeptide binding]; other site 1069534002503 catalytic residue [active] 1069534002504 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1069534002505 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1069534002506 GrpE; Region: GrpE; pfam01025 1069534002507 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1069534002508 dimer interface [polypeptide binding]; other site 1069534002509 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1069534002510 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1069534002511 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1069534002512 nucleotide binding site [chemical binding]; other site 1069534002513 NEF interaction site [polypeptide binding]; other site 1069534002514 SBD interface [polypeptide binding]; other site 1069534002515 chaperone protein DnaJ; Provisional; Region: PRK14276 1069534002516 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1069534002517 HSP70 interaction site [polypeptide binding]; other site 1069534002518 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1069534002519 substrate binding site [polypeptide binding]; other site 1069534002520 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1069534002521 Zn binding sites [ion binding]; other site 1069534002522 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1069534002523 substrate binding site [polypeptide binding]; other site 1069534002524 dimer interface [polypeptide binding]; other site 1069534002525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1069534002526 binding surface 1069534002527 TPR motif; other site 1069534002528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1069534002529 binding surface 1069534002530 TPR motif; other site 1069534002531 Region in Clathrin and VPS; Region: Clathrin; pfam00637 1069534002532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1069534002533 binding surface 1069534002534 TPR motif; other site 1069534002535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1069534002536 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1069534002537 putative uracil binding site [chemical binding]; other site 1069534002538 putative active site [active] 1069534002539 Peptidase family C69; Region: Peptidase_C69; pfam03577 1069534002540 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1069534002541 active site 1 [active] 1069534002542 dimer interface [polypeptide binding]; other site 1069534002543 hexamer interface [polypeptide binding]; other site 1069534002544 active site 2 [active] 1069534002545 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1069534002546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1069534002547 active site 1069534002548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1069534002549 substrate binding site [chemical binding]; other site 1069534002550 catalytic residues [active] 1069534002551 dimer interface [polypeptide binding]; other site 1069534002552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534002553 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1069534002554 active site 1069534002555 motif I; other site 1069534002556 motif II; other site 1069534002557 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1069534002558 DNA methylase; Region: N6_N4_Mtase; cl17433 1069534002559 DNA methylase; Region: N6_N4_Mtase; cl17433 1069534002560 DNA methylase; Region: N6_N4_Mtase; cl17433 1069534002561 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1069534002562 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1069534002563 ATP binding site [chemical binding]; other site 1069534002564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1069534002565 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1069534002566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534002567 ATP binding site [chemical binding]; other site 1069534002568 putative Mg++ binding site [ion binding]; other site 1069534002569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534002570 nucleotide binding region [chemical binding]; other site 1069534002571 ATP-binding site [chemical binding]; other site 1069534002572 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534002573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534002574 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1069534002575 Probable transposase; Region: OrfB_IS605; pfam01385 1069534002576 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534002577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534002578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534002579 sequence-specific DNA binding site [nucleotide binding]; other site 1069534002580 salt bridge; other site 1069534002581 NUMOD4 motif; Region: NUMOD4; pfam07463 1069534002582 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1069534002583 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1069534002584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1069534002585 esterase; Provisional; Region: PRK10566 1069534002586 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1069534002587 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1069534002588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1069534002589 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1069534002590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534002591 S-adenosylmethionine binding site [chemical binding]; other site 1069534002592 Uncharacterized conserved protein [Function unknown]; Region: COG3270 1069534002593 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1069534002594 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1069534002595 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1069534002596 homotetramer interface [polypeptide binding]; other site 1069534002597 FMN binding site [chemical binding]; other site 1069534002598 homodimer contacts [polypeptide binding]; other site 1069534002599 putative active site [active] 1069534002600 putative substrate binding site [chemical binding]; other site 1069534002601 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1069534002602 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1069534002603 diphosphomevalonate decarboxylase; Region: PLN02407 1069534002604 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1069534002605 mevalonate kinase; Region: mevalon_kin; TIGR00549 1069534002606 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1069534002607 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1069534002608 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1069534002609 active site 1069534002610 catalytic site [active] 1069534002611 substrate binding site [chemical binding]; other site 1069534002612 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1069534002613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1069534002614 aspartate aminotransferase; Provisional; Region: PRK05764 1069534002615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534002616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534002617 homodimer interface [polypeptide binding]; other site 1069534002618 catalytic residue [active] 1069534002619 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1069534002620 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1069534002621 putative dimer interface [polypeptide binding]; other site 1069534002622 putative anticodon binding site; other site 1069534002623 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1069534002624 homodimer interface [polypeptide binding]; other site 1069534002625 motif 1; other site 1069534002626 motif 2; other site 1069534002627 active site 1069534002628 motif 3; other site 1069534002629 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1069534002630 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1069534002631 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1069534002632 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1069534002633 minor groove reading motif; other site 1069534002634 helix-hairpin-helix signature motif; other site 1069534002635 substrate binding pocket [chemical binding]; other site 1069534002636 active site 1069534002637 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1069534002638 Transglycosylase; Region: Transgly; pfam00912 1069534002639 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1069534002640 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1069534002641 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1069534002642 hypothetical protein; Provisional; Region: PRK13660 1069534002643 cell division protein GpsB; Provisional; Region: PRK14127 1069534002644 DivIVA domain; Region: DivI1A_domain; TIGR03544 1069534002645 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1069534002646 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1069534002647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1069534002648 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1069534002649 RNA/DNA hybrid binding site [nucleotide binding]; other site 1069534002650 active site 1069534002651 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1069534002652 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1069534002653 Potassium binding sites [ion binding]; other site 1069534002654 Cesium cation binding sites [ion binding]; other site 1069534002655 lipoprotein signal peptidase; Provisional; Region: PRK14797 1069534002656 lipoprotein signal peptidase; Provisional; Region: PRK14787 1069534002657 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1069534002658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534002659 RNA binding surface [nucleotide binding]; other site 1069534002660 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1069534002661 active site 1069534002662 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1069534002663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534002664 active site 1069534002665 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1069534002666 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1069534002667 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1069534002668 dihydroorotase; Validated; Region: pyrC; PRK09357 1069534002669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1069534002670 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1069534002671 active site 1069534002672 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1069534002673 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1069534002674 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1069534002675 catalytic site [active] 1069534002676 subunit interface [polypeptide binding]; other site 1069534002677 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1069534002678 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1069534002679 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1069534002680 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1069534002681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1069534002682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1069534002683 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1069534002684 IMP binding site; other site 1069534002685 dimer interface [polypeptide binding]; other site 1069534002686 interdomain contacts; other site 1069534002687 partial ornithine binding site; other site 1069534002688 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1069534002689 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1069534002690 heterodimer interface [polypeptide binding]; other site 1069534002691 active site 1069534002692 FMN binding site [chemical binding]; other site 1069534002693 homodimer interface [polypeptide binding]; other site 1069534002694 substrate binding site [chemical binding]; other site 1069534002695 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1069534002696 active site 1069534002697 dimer interface [polypeptide binding]; other site 1069534002698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534002699 active site 1069534002700 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1069534002701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1069534002702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1069534002703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1069534002704 dimerization interface [polypeptide binding]; other site 1069534002705 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1069534002706 DHH family; Region: DHH; pfam01368 1069534002707 DHHA2 domain; Region: DHHA2; pfam02833 1069534002708 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1069534002709 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1069534002710 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1069534002711 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1069534002712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534002713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534002714 homodimer interface [polypeptide binding]; other site 1069534002715 catalytic residue [active] 1069534002716 glutamate racemase; Provisional; Region: PRK00865 1069534002717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1069534002718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1069534002719 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1069534002720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534002721 motif II; other site 1069534002722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534002723 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1069534002724 active site 1069534002725 motif I; other site 1069534002726 motif II; other site 1069534002727 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1069534002728 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1069534002729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1069534002730 active site 1069534002731 metal binding site [ion binding]; metal-binding site 1069534002732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534002733 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1069534002734 putative active site [active] 1069534002735 nucleotide binding site [chemical binding]; other site 1069534002736 nudix motif; other site 1069534002737 putative metal binding site [ion binding]; other site 1069534002738 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1069534002739 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1069534002740 Catalytic site [active] 1069534002741 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1069534002742 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1069534002743 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1069534002744 EDD domain protein, DegV family; Region: DegV; TIGR00762 1069534002745 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1069534002746 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1069534002747 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1069534002748 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1069534002749 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1069534002750 CAP-like domain; other site 1069534002751 active site 1069534002752 primary dimer interface [polypeptide binding]; other site 1069534002753 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534002754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1069534002755 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1069534002756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534002757 ATP binding site [chemical binding]; other site 1069534002758 Mg2+ binding site [ion binding]; other site 1069534002759 G-X-G motif; other site 1069534002760 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1069534002761 anchoring element; other site 1069534002762 dimer interface [polypeptide binding]; other site 1069534002763 ATP binding site [chemical binding]; other site 1069534002764 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1069534002765 active site 1069534002766 putative metal-binding site [ion binding]; other site 1069534002767 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1069534002768 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1069534002769 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1069534002770 active site 1069534002771 catalytic residues [active] 1069534002772 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1069534002773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534002774 Walker A motif; other site 1069534002775 ATP binding site [chemical binding]; other site 1069534002776 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1069534002777 Walker B motif; other site 1069534002778 arginine finger; other site 1069534002779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1069534002780 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1069534002781 active site 1069534002782 HslU subunit interaction site [polypeptide binding]; other site 1069534002783 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1069534002784 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1069534002785 active site 1069534002786 Int/Topo IB signature motif; other site 1069534002787 benzoate transport; Region: 2A0115; TIGR00895 1069534002788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534002789 putative substrate translocation pore; other site 1069534002790 Similar to Nicotinate-nucleotide pyrophosphorylase; predicted to be non-functional due to frameshift 1069534002791 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1069534002792 Glucose inhibited division protein A; Region: GIDA; pfam01134 1069534002793 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1069534002794 DNA topoisomerase I; Validated; Region: PRK05582 1069534002795 active site 1069534002796 interdomain interaction site; other site 1069534002797 putative metal-binding site [ion binding]; other site 1069534002798 nucleotide binding site [chemical binding]; other site 1069534002799 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1069534002800 domain I; other site 1069534002801 DNA binding groove [nucleotide binding] 1069534002802 phosphate binding site [ion binding]; other site 1069534002803 domain II; other site 1069534002804 domain III; other site 1069534002805 nucleotide binding site [chemical binding]; other site 1069534002806 catalytic site [active] 1069534002807 domain IV; other site 1069534002808 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1069534002809 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1069534002810 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1069534002811 DNA protecting protein DprA; Region: dprA; TIGR00732 1069534002812 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1069534002813 RNA/DNA hybrid binding site [nucleotide binding]; other site 1069534002814 active site 1069534002815 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1069534002816 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1069534002817 GTP/Mg2+ binding site [chemical binding]; other site 1069534002818 G4 box; other site 1069534002819 G5 box; other site 1069534002820 G1 box; other site 1069534002821 Switch I region; other site 1069534002822 G2 box; other site 1069534002823 G3 box; other site 1069534002824 Switch II region; other site 1069534002825 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1069534002826 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1069534002827 Catalytic site [active] 1069534002828 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1069534002829 C-terminal peptidase (prc); Region: prc; TIGR00225 1069534002830 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1069534002831 protein binding site [polypeptide binding]; other site 1069534002832 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1069534002833 Catalytic dyad [active] 1069534002834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1069534002835 hypothetical protein; Provisional; Region: PRK13672 1069534002836 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1069534002837 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1069534002838 active site 1069534002839 catalytic triad [active] 1069534002840 oxyanion hole [active] 1069534002841 Similar to dihydrofolate reductase; predicted to be non-functional due toframeshift 1069534002842 thymidylate synthase; Region: thym_sym; TIGR03284 1069534002843 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1069534002844 dimerization interface [polypeptide binding]; other site 1069534002845 active site 1069534002846 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1069534002847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534002848 Walker A/P-loop; other site 1069534002849 ATP binding site [chemical binding]; other site 1069534002850 Q-loop/lid; other site 1069534002851 ABC transporter signature motif; other site 1069534002852 Walker B; other site 1069534002853 D-loop; other site 1069534002854 H-loop/switch region; other site 1069534002855 ABC transporter; Region: ABC_tran_2; pfam12848 1069534002856 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534002857 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1069534002858 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1069534002859 active site 1069534002860 NTP binding site [chemical binding]; other site 1069534002861 metal binding triad [ion binding]; metal-binding site 1069534002862 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1069534002863 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1069534002864 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1069534002865 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1069534002866 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1069534002867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1069534002868 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1069534002869 non-specific DNA interactions [nucleotide binding]; other site 1069534002870 DNA binding site [nucleotide binding] 1069534002871 sequence specific DNA binding site [nucleotide binding]; other site 1069534002872 putative cAMP binding site [chemical binding]; other site 1069534002873 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1069534002874 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1069534002875 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534002876 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534002877 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534002878 Cache domain; Region: Cache_1; pfam02743 1069534002879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534002880 dimer interface [polypeptide binding]; other site 1069534002881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534002882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534002883 dimer interface [polypeptide binding]; other site 1069534002884 putative CheW interface [polypeptide binding]; other site 1069534002885 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534002886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534002887 non-specific DNA binding site [nucleotide binding]; other site 1069534002888 salt bridge; other site 1069534002889 sequence-specific DNA binding site [nucleotide binding]; other site 1069534002890 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1069534002891 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1069534002892 ligand binding site [chemical binding]; other site 1069534002893 flexible hinge region; other site 1069534002894 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1069534002895 putative switch regulator; other site 1069534002896 non-specific DNA interactions [nucleotide binding]; other site 1069534002897 DNA binding site [nucleotide binding] 1069534002898 sequence specific DNA binding site [nucleotide binding]; other site 1069534002899 putative cAMP binding site [chemical binding]; other site 1069534002900 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534002901 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534002902 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534002903 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1069534002904 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1069534002905 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 1069534002906 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 1069534002907 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1069534002908 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 1069534002909 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1069534002910 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 1069534002911 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1069534002912 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1069534002913 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1069534002914 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1069534002915 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1069534002916 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1069534002917 active site 1069534002918 Riboflavin kinase; Region: Flavokinase; pfam01687 1069534002919 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1069534002920 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1069534002921 RNA binding site [nucleotide binding]; other site 1069534002922 active site 1069534002923 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1069534002924 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1069534002925 translation initiation factor IF-2; Region: IF-2; TIGR00487 1069534002926 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1069534002927 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1069534002928 G1 box; other site 1069534002929 putative GEF interaction site [polypeptide binding]; other site 1069534002930 GTP/Mg2+ binding site [chemical binding]; other site 1069534002931 Switch I region; other site 1069534002932 G2 box; other site 1069534002933 G3 box; other site 1069534002934 Switch II region; other site 1069534002935 G4 box; other site 1069534002936 G5 box; other site 1069534002937 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1069534002938 Translation-initiation factor 2; Region: IF-2; pfam11987 1069534002939 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1069534002940 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1069534002941 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1069534002942 putative RNA binding cleft [nucleotide binding]; other site 1069534002943 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1069534002944 NusA N-terminal domain; Region: NusA_N; pfam08529 1069534002945 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1069534002946 RNA binding site [nucleotide binding]; other site 1069534002947 homodimer interface [polypeptide binding]; other site 1069534002948 NusA-like KH domain; Region: KH_5; pfam13184 1069534002949 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1069534002950 G-X-X-G motif; other site 1069534002951 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1069534002952 Sm and related proteins; Region: Sm_like; cl00259 1069534002953 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1069534002954 putative oligomer interface [polypeptide binding]; other site 1069534002955 putative RNA binding site [nucleotide binding]; other site 1069534002956 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1069534002957 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1069534002958 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1069534002959 generic binding surface II; other site 1069534002960 generic binding surface I; other site 1069534002961 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1069534002962 active site 1069534002963 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1069534002964 active site 1069534002965 catalytic site [active] 1069534002966 substrate binding site [chemical binding]; other site 1069534002967 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1069534002968 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1069534002969 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1069534002970 active site 1069534002971 nucleophile elbow; other site 1069534002972 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1069534002973 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1069534002974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534002975 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1069534002976 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1069534002977 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1069534002978 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534002979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534002980 Abi-like protein; Region: Abi_2; pfam07751 1069534002981 Similar to Conserved hypothetical protein; predicted to be non-functional due to possible truncation 1069534002982 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 1069534002983 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1069534002984 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1069534002985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1069534002986 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1069534002987 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1069534002988 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1069534002989 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1069534002990 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1069534002991 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1069534002992 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 1069534002993 NUMOD4 motif; Region: NUMOD4; pfam07463 1069534002994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1069534002995 Similar to Glucanotransferase; predicted to be non-functional due to truncation 1069534002996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534002997 Probable transposase; Region: OrfB_IS605; pfam01385 1069534002998 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534002999 Similar to hypothetical protein; predicted to me non-functional due to truncation 1069534003000 similar to Conserved hypothetical protein; predicted to be non-functional due to an In frame stop codon 1069534003001 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1069534003002 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 1069534003003 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1069534003004 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1069534003005 active site 1069534003006 PHP Thumb interface [polypeptide binding]; other site 1069534003007 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1069534003008 generic binding surface I; other site 1069534003009 generic binding surface II; other site 1069534003010 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1069534003011 HTH-like domain; Region: HTH_21; pfam13276 1069534003012 Integrase core domain; Region: rve; pfam00665 1069534003013 Integrase core domain; Region: rve_2; pfam13333 1069534003014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534003015 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534003016 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1069534003017 Clp amino terminal domain; Region: Clp_N; pfam02861 1069534003018 Clp amino terminal domain; Region: Clp_N; pfam02861 1069534003019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534003020 Walker A motif; other site 1069534003021 ATP binding site [chemical binding]; other site 1069534003022 Walker B motif; other site 1069534003023 arginine finger; other site 1069534003024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534003025 Walker A motif; other site 1069534003026 ATP binding site [chemical binding]; other site 1069534003027 Walker B motif; other site 1069534003028 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1069534003029 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1069534003030 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1069534003031 peptide binding site [polypeptide binding]; other site 1069534003032 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1069534003033 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1069534003034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534003035 ATP binding site [chemical binding]; other site 1069534003036 putative Mg++ binding site [ion binding]; other site 1069534003037 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1069534003038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534003039 nucleotide binding region [chemical binding]; other site 1069534003040 ATP-binding site [chemical binding]; other site 1069534003041 peptidase T; Region: peptidase-T; TIGR01882 1069534003042 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1069534003043 metal binding site [ion binding]; metal-binding site 1069534003044 dimer interface [polypeptide binding]; other site 1069534003045 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1069534003046 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1069534003047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1069534003048 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1069534003049 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1069534003050 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1069534003051 Family of unknown function (DUF633); Region: DUF633; pfam04816 1069534003052 GTP-binding protein LepA; Provisional; Region: PRK05433 1069534003053 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1069534003054 G1 box; other site 1069534003055 putative GEF interaction site [polypeptide binding]; other site 1069534003056 GTP/Mg2+ binding site [chemical binding]; other site 1069534003057 Switch I region; other site 1069534003058 G2 box; other site 1069534003059 G3 box; other site 1069534003060 Switch II region; other site 1069534003061 G4 box; other site 1069534003062 G5 box; other site 1069534003063 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1069534003064 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1069534003065 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1069534003066 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1069534003067 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1069534003068 dimer interface [polypeptide binding]; other site 1069534003069 active site 1069534003070 Acylphosphatase; Region: Acylphosphatase; pfam00708 1069534003071 OxaA-like protein precursor; Provisional; Region: PRK02463 1069534003072 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1069534003073 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1069534003074 TrkA-N domain; Region: TrkA_N; pfam02254 1069534003075 TrkA-C domain; Region: TrkA_C; pfam02080 1069534003076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534003077 active site 1069534003078 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1069534003079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1069534003080 NAD(P) binding site [chemical binding]; other site 1069534003081 active site 1069534003082 ribonuclease Z; Region: RNase_Z; TIGR02651 1069534003083 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1069534003084 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1069534003085 catalytic triad [active] 1069534003086 catalytic triad [active] 1069534003087 oxyanion hole [active] 1069534003088 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1069534003089 GTP1/OBG; Region: GTP1_OBG; pfam01018 1069534003090 Obg GTPase; Region: Obg; cd01898 1069534003091 G1 box; other site 1069534003092 GTP/Mg2+ binding site [chemical binding]; other site 1069534003093 Switch I region; other site 1069534003094 G2 box; other site 1069534003095 G3 box; other site 1069534003096 Switch II region; other site 1069534003097 G4 box; other site 1069534003098 G5 box; other site 1069534003099 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1069534003100 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1069534003101 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1069534003102 GIY-YIG motif/motif A; other site 1069534003103 active site 1069534003104 catalytic site [active] 1069534003105 putative DNA binding site [nucleotide binding]; other site 1069534003106 metal binding site [ion binding]; metal-binding site 1069534003107 UvrB/uvrC motif; Region: UVR; pfam02151 1069534003108 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1069534003109 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1069534003110 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1069534003111 Walker A/P-loop; other site 1069534003112 ATP binding site [chemical binding]; other site 1069534003113 Q-loop/lid; other site 1069534003114 ABC transporter signature motif; other site 1069534003115 Walker B; other site 1069534003116 D-loop; other site 1069534003117 H-loop/switch region; other site 1069534003118 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1069534003119 putative metal binding site [ion binding]; other site 1069534003120 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1069534003121 G1 box; other site 1069534003122 GTP/Mg2+ binding site [chemical binding]; other site 1069534003123 Switch I region; other site 1069534003124 G2 box; other site 1069534003125 G3 box; other site 1069534003126 Switch II region; other site 1069534003127 G4 box; other site 1069534003128 G5 box; other site 1069534003129 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1069534003130 hypothetical protein; Provisional; Region: PRK13670 1069534003131 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1069534003132 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1069534003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534003134 S-adenosylmethionine binding site [chemical binding]; other site 1069534003135 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1069534003136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534003137 Zn2+ binding site [ion binding]; other site 1069534003138 Mg2+ binding site [ion binding]; other site 1069534003139 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1069534003140 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1069534003141 active site 1069534003142 (T/H)XGH motif; other site 1069534003143 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1069534003144 GTPase YqeH; Provisional; Region: PRK13796 1069534003145 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1069534003146 GTP/Mg2+ binding site [chemical binding]; other site 1069534003147 G4 box; other site 1069534003148 G5 box; other site 1069534003149 G1 box; other site 1069534003150 Switch I region; other site 1069534003151 G2 box; other site 1069534003152 G3 box; other site 1069534003153 Switch II region; other site 1069534003154 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1069534003155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534003156 active site 1069534003157 motif I; other site 1069534003158 motif II; other site 1069534003159 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1069534003160 23S rRNA binding site [nucleotide binding]; other site 1069534003161 L21 binding site [polypeptide binding]; other site 1069534003162 L13 binding site [polypeptide binding]; other site 1069534003163 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1069534003164 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1069534003165 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1069534003166 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1069534003167 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1069534003168 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1069534003169 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1069534003170 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1069534003171 active site 1069534003172 dimer interface [polypeptide binding]; other site 1069534003173 motif 1; other site 1069534003174 motif 2; other site 1069534003175 motif 3; other site 1069534003176 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1069534003177 anticodon binding site; other site 1069534003178 primosomal protein DnaI; Reviewed; Region: PRK08939 1069534003179 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1069534003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534003181 Walker A motif; other site 1069534003182 ATP binding site [chemical binding]; other site 1069534003183 Walker B motif; other site 1069534003184 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1069534003185 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1069534003186 ATP cone domain; Region: ATP-cone; pfam03477 1069534003187 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1069534003188 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1069534003189 CoA-binding site [chemical binding]; other site 1069534003190 ATP-binding [chemical binding]; other site 1069534003191 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1069534003192 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1069534003193 DNA binding site [nucleotide binding] 1069534003194 catalytic residue [active] 1069534003195 H2TH interface [polypeptide binding]; other site 1069534003196 putative catalytic residues [active] 1069534003197 turnover-facilitating residue; other site 1069534003198 intercalation triad [nucleotide binding]; other site 1069534003199 8OG recognition residue [nucleotide binding]; other site 1069534003200 putative reading head residues; other site 1069534003201 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1069534003202 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1069534003203 DNA polymerase I; Provisional; Region: PRK05755 1069534003204 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1069534003205 active site 1069534003206 metal binding site 1 [ion binding]; metal-binding site 1069534003207 putative 5' ssDNA interaction site; other site 1069534003208 metal binding site 3; metal-binding site 1069534003209 metal binding site 2 [ion binding]; metal-binding site 1069534003210 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1069534003211 putative DNA binding site [nucleotide binding]; other site 1069534003212 putative metal binding site [ion binding]; other site 1069534003213 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1069534003214 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1069534003215 active site 1069534003216 DNA binding site [nucleotide binding] 1069534003217 catalytic site [active] 1069534003218 Similar to polysaccharide deacetylase; predicted to be non-functional due to truncation 1069534003219 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1069534003220 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1069534003221 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1069534003222 active site 2 [active] 1069534003223 active site 1 [active] 1069534003224 Cupin domain; Region: Cupin_2; cl17218 1069534003225 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1069534003226 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1069534003227 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534003228 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1069534003229 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1069534003230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1069534003231 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1069534003232 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1069534003233 putative tRNA-binding site [nucleotide binding]; other site 1069534003234 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1069534003235 catalytic residues [active] 1069534003236 Predicted small secreted protein [Function unknown]; Region: COG5584 1069534003237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534003238 S-adenosylmethionine binding site [chemical binding]; other site 1069534003239 Phosphotransferase enzyme family; Region: APH; pfam01636 1069534003240 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1069534003241 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1069534003242 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1069534003243 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1069534003244 Walker A/P-loop; other site 1069534003245 ATP binding site [chemical binding]; other site 1069534003246 Q-loop/lid; other site 1069534003247 ABC transporter signature motif; other site 1069534003248 Walker B; other site 1069534003249 D-loop; other site 1069534003250 H-loop/switch region; other site 1069534003251 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1069534003252 HIT family signature motif; other site 1069534003253 catalytic residue [active] 1069534003254 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1069534003255 SurA N-terminal domain; Region: SurA_N_3; cl07813 1069534003256 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1069534003257 similar to transposase; predicted to be non-functional due to truncation 1069534003258 Similar to ABC transporter-related protein; predicted to be non-functional due to truncation 1069534003259 sugar phosphate phosphatase; Provisional; Region: PRK10513 1069534003260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534003261 motif II; other site 1069534003262 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1069534003263 similar to DeoR family transcriptional regulator; predicted to be non-functional due to truncation 1069534003264 similar to Hypothetical protein; predicted to be non-funtional due to truncation 1069534003265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1069534003266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534003267 DNA binding site [nucleotide binding] 1069534003268 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1069534003269 putative dimerization interface [polypeptide binding]; other site 1069534003270 putative ligand binding site [chemical binding]; other site 1069534003271 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1069534003272 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1069534003273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534003274 Walker A/P-loop; other site 1069534003275 ATP binding site [chemical binding]; other site 1069534003276 Q-loop/lid; other site 1069534003277 ABC transporter signature motif; other site 1069534003278 Walker B; other site 1069534003279 D-loop; other site 1069534003280 H-loop/switch region; other site 1069534003281 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1069534003282 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1069534003283 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1069534003284 Cache domain; Region: Cache_1; pfam02743 1069534003285 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534003286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534003287 dimer interface [polypeptide binding]; other site 1069534003288 putative CheW interface [polypeptide binding]; other site 1069534003289 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1069534003290 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1069534003291 generic binding surface I; other site 1069534003292 generic binding surface II; other site 1069534003293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534003294 Zn2+ binding site [ion binding]; other site 1069534003295 Mg2+ binding site [ion binding]; other site 1069534003296 hypothetical protein; Provisional; Region: PRK13676 1069534003297 Similar to Multimodular transpeptidase-transglycosylase PBP 2A; predicted to be non-functional due to frameshift 1069534003298 Arginine repressor [Transcription]; Region: ArgR; COG1438 1069534003299 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1069534003300 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1069534003301 Similar to ABC-type oligopeptide transport system, periplasmic component; predicted to be non-functional due to frameshift 1069534003302 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1069534003303 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1069534003304 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1069534003305 active site 1069534003306 HIGH motif; other site 1069534003307 KMSK motif region; other site 1069534003308 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1069534003309 tRNA binding surface [nucleotide binding]; other site 1069534003310 anticodon binding site; other site 1069534003311 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1069534003312 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1069534003313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1069534003314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1069534003315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1069534003316 dimerization interface [polypeptide binding]; other site 1069534003317 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1069534003318 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1069534003319 Zn binding site [ion binding]; other site 1069534003320 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1069534003321 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1069534003322 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1069534003323 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1069534003324 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1069534003325 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1069534003326 purine monophosphate binding site [chemical binding]; other site 1069534003327 dimer interface [polypeptide binding]; other site 1069534003328 putative catalytic residues [active] 1069534003329 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1069534003330 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1069534003331 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1069534003332 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1069534003333 active site 1069534003334 substrate binding site [chemical binding]; other site 1069534003335 cosubstrate binding site; other site 1069534003336 catalytic site [active] 1069534003337 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1069534003338 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1069534003339 dimerization interface [polypeptide binding]; other site 1069534003340 putative ATP binding site [chemical binding]; other site 1069534003341 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1069534003342 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1069534003343 active site 1069534003344 tetramer interface [polypeptide binding]; other site 1069534003345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534003346 active site 1069534003347 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1069534003348 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1069534003349 dimerization interface [polypeptide binding]; other site 1069534003350 ATP binding site [chemical binding]; other site 1069534003351 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1069534003352 dimerization interface [polypeptide binding]; other site 1069534003353 ATP binding site [chemical binding]; other site 1069534003354 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1069534003355 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1069534003356 putative active site [active] 1069534003357 catalytic triad [active] 1069534003358 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1069534003359 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1069534003360 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1069534003361 ATP binding site [chemical binding]; other site 1069534003362 active site 1069534003363 substrate binding site [chemical binding]; other site 1069534003364 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1069534003365 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1069534003366 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1069534003367 nucleotide binding site [chemical binding]; other site 1069534003368 adenylosuccinate lyase; Provisional; Region: PRK07492 1069534003369 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1069534003370 tetramer interface [polypeptide binding]; other site 1069534003371 active site 1069534003372 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1069534003373 ATP-grasp domain; Region: ATP-grasp; pfam02222 1069534003374 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1069534003375 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1069534003376 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1069534003377 Substrate-binding site [chemical binding]; other site 1069534003378 Substrate specificity [chemical binding]; other site 1069534003379 Protein of unknown function (DUF975); Region: DUF975; cl10504 1069534003380 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1069534003381 TrkA-N domain; Region: TrkA_N; pfam02254 1069534003382 TrkA-C domain; Region: TrkA_C; pfam02080 1069534003383 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1069534003384 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1069534003385 Transposase; Region: HTH_Tnp_1; cl17663 1069534003386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534003387 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534003388 Integrase core domain; Region: rve; pfam00665 1069534003389 Integrase core domain; Region: rve_3; cl15866 1069534003390 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1069534003391 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1069534003392 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1069534003393 dimer interface [polypeptide binding]; other site 1069534003394 motif 1; other site 1069534003395 active site 1069534003396 motif 2; other site 1069534003397 motif 3; other site 1069534003398 DNA repair protein RecO; Region: reco; TIGR00613 1069534003399 Recombination protein O N terminal; Region: RecO_N; pfam11967 1069534003400 Recombination protein O C terminal; Region: RecO_C; pfam02565 1069534003401 GTPase Era; Reviewed; Region: era; PRK00089 1069534003402 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1069534003403 G1 box; other site 1069534003404 GTP/Mg2+ binding site [chemical binding]; other site 1069534003405 Switch I region; other site 1069534003406 G2 box; other site 1069534003407 Switch II region; other site 1069534003408 G3 box; other site 1069534003409 G4 box; other site 1069534003410 G5 box; other site 1069534003411 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1069534003412 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1069534003413 metal-binding heat shock protein; Provisional; Region: PRK00016 1069534003414 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1069534003415 PhoH-like protein; Region: PhoH; pfam02562 1069534003416 Yqey-like protein; Region: YqeY; pfam09424 1069534003417 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1069534003418 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1069534003419 Amino acid permease; Region: AA_permease_2; pfam13520 1069534003420 endonuclease IV; Provisional; Region: PRK01060 1069534003421 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1069534003422 AP (apurinic/apyrimidinic) site pocket; other site 1069534003423 DNA interaction; other site 1069534003424 Metal-binding active site; metal-binding site 1069534003425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1069534003426 active site 1069534003427 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1069534003428 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1069534003429 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1069534003430 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534003431 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534003432 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534003433 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534003434 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1069534003435 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1069534003436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534003437 motif II; other site 1069534003438 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1069534003439 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1069534003440 putative active site [active] 1069534003441 dimerization interface [polypeptide binding]; other site 1069534003442 putative tRNAtyr binding site [nucleotide binding]; other site 1069534003443 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1069534003444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534003445 Zn2+ binding site [ion binding]; other site 1069534003446 Mg2+ binding site [ion binding]; other site 1069534003447 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1069534003448 synthetase active site [active] 1069534003449 NTP binding site [chemical binding]; other site 1069534003450 metal binding site [ion binding]; metal-binding site 1069534003451 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1069534003452 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1069534003453 Similar to Conserved hypothetical protein; predicted to be nonfunctional due to frameshift 1069534003454 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1069534003455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534003456 S-adenosylmethionine binding site [chemical binding]; other site 1069534003457 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1069534003458 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1069534003459 active site 1069534003460 Ion channel; Region: Ion_trans_2; pfam07885 1069534003461 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1069534003462 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1069534003463 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1069534003464 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1069534003465 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1069534003466 Sugar specificity; other site 1069534003467 Pyrimidine base specificity; other site 1069534003468 ATP-binding site [chemical binding]; other site 1069534003469 YceG-like family; Region: YceG; pfam02618 1069534003470 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1069534003471 dimerization interface [polypeptide binding]; other site 1069534003472 Similar to Phenylalanyl tRNA synthetase beta; predicted to be nonfunctional due to frameshift 1069534003473 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1069534003474 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1069534003475 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1069534003476 dimer interface [polypeptide binding]; other site 1069534003477 motif 1; other site 1069534003478 active site 1069534003479 motif 2; other site 1069534003480 motif 3; other site 1069534003481 Predicted transcriptional regulators [Transcription]; Region: COG1733 1069534003482 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1069534003483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1069534003484 Zn2+ binding site [ion binding]; other site 1069534003485 Mg2+ binding site [ion binding]; other site 1069534003486 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1069534003487 IHF dimer interface [polypeptide binding]; other site 1069534003488 IHF - DNA interface [nucleotide binding]; other site 1069534003489 GTP-binding protein Der; Reviewed; Region: PRK00093 1069534003490 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1069534003491 G1 box; other site 1069534003492 GTP/Mg2+ binding site [chemical binding]; other site 1069534003493 Switch I region; other site 1069534003494 G2 box; other site 1069534003495 Switch II region; other site 1069534003496 G3 box; other site 1069534003497 G4 box; other site 1069534003498 G5 box; other site 1069534003499 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1069534003500 G1 box; other site 1069534003501 GTP/Mg2+ binding site [chemical binding]; other site 1069534003502 Switch I region; other site 1069534003503 G2 box; other site 1069534003504 G3 box; other site 1069534003505 Switch II region; other site 1069534003506 G4 box; other site 1069534003507 G5 box; other site 1069534003508 Similar to 30s ribosomal protein S1; predicted to be non-functional due to frameshift 1069534003509 cytidylate kinase; Provisional; Region: cmk; PRK00023 1069534003510 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1069534003511 CMP-binding site; other site 1069534003512 The sites determining sugar specificity; other site 1069534003513 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534003514 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1069534003515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534003516 ATP binding site [chemical binding]; other site 1069534003517 putative Mg++ binding site [ion binding]; other site 1069534003518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534003519 nucleotide binding region [chemical binding]; other site 1069534003520 ATP-binding site [chemical binding]; other site 1069534003521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1069534003522 manganese transport protein MntH; Reviewed; Region: PRK00701 1069534003523 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1069534003524 Predicted membrane protein [Function unknown]; Region: COG3601 1069534003525 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1069534003526 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1069534003527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534003528 RNA binding surface [nucleotide binding]; other site 1069534003529 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1069534003530 active site 1069534003531 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1069534003532 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1069534003533 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1069534003534 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1069534003535 active site 1069534003536 Int/Topo IB signature motif; other site 1069534003537 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1069534003538 putative DNA binding helix; other site 1069534003539 metal binding site 2 [ion binding]; metal-binding site 1069534003540 metal binding site 1 [ion binding]; metal-binding site 1069534003541 dimer interface [polypeptide binding]; other site 1069534003542 structural Zn2+ binding site [ion binding]; other site 1069534003543 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1069534003544 S1 domain; Region: S1_2; pfam13509 1069534003545 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1069534003546 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1069534003547 RimM N-terminal domain; Region: RimM; pfam01782 1069534003548 PRC-barrel domain; Region: PRC; pfam05239 1069534003549 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1069534003550 KH domain; Region: KH_4; pfam13083 1069534003551 G-X-X-G motif; other site 1069534003552 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1069534003553 signal recognition particle protein; Provisional; Region: PRK10867 1069534003554 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1069534003555 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1069534003556 P loop; other site 1069534003557 GTP binding site [chemical binding]; other site 1069534003558 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1069534003559 putative DNA-binding protein; Validated; Region: PRK00118 1069534003560 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1069534003561 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1069534003562 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1069534003563 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1069534003564 P loop; other site 1069534003565 GTP binding site [chemical binding]; other site 1069534003566 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1069534003567 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1069534003568 Walker A/P-loop; other site 1069534003569 ATP binding site [chemical binding]; other site 1069534003570 Q-loop/lid; other site 1069534003571 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1069534003572 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1069534003573 ABC transporter signature motif; other site 1069534003574 Walker B; other site 1069534003575 D-loop; other site 1069534003576 H-loop/switch region; other site 1069534003577 ribonuclease III; Reviewed; Region: rnc; PRK00102 1069534003578 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1069534003579 dimerization interface [polypeptide binding]; other site 1069534003580 active site 1069534003581 metal binding site [ion binding]; metal-binding site 1069534003582 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1069534003583 dsRNA binding site [nucleotide binding]; other site 1069534003584 acyl carrier protein; Provisional; Region: acpP; PRK00982 1069534003585 putative phosphate acyltransferase; Provisional; Region: PRK05331 1069534003586 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1069534003587 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1069534003588 generic binding surface II; other site 1069534003589 ssDNA binding site; other site 1069534003590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534003591 ATP binding site [chemical binding]; other site 1069534003592 putative Mg++ binding site [ion binding]; other site 1069534003593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534003594 nucleotide binding region [chemical binding]; other site 1069534003595 ATP-binding site [chemical binding]; other site 1069534003596 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1069534003597 DAK2 domain; Region: Dak2; pfam02734 1069534003598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1069534003599 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1069534003600 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1069534003601 Thiamine pyrophosphokinase; Region: TPK; cd07995 1069534003602 active site 1069534003603 dimerization interface [polypeptide binding]; other site 1069534003604 thiamine binding site [chemical binding]; other site 1069534003605 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1069534003606 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1069534003607 substrate binding site [chemical binding]; other site 1069534003608 hexamer interface [polypeptide binding]; other site 1069534003609 metal binding site [ion binding]; metal-binding site 1069534003610 GTPase RsgA; Reviewed; Region: PRK00098 1069534003611 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1069534003612 RNA binding site [nucleotide binding]; other site 1069534003613 homodimer interface [polypeptide binding]; other site 1069534003614 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1069534003615 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1069534003616 GTP/Mg2+ binding site [chemical binding]; other site 1069534003617 G4 box; other site 1069534003618 G5 box; other site 1069534003619 G1 box; other site 1069534003620 Switch I region; other site 1069534003621 G2 box; other site 1069534003622 G3 box; other site 1069534003623 Switch II region; other site 1069534003624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1069534003625 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1069534003626 active site 1069534003627 ATP binding site [chemical binding]; other site 1069534003628 substrate binding site [chemical binding]; other site 1069534003629 activation loop (A-loop); other site 1069534003630 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1069534003631 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1069534003632 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1069534003633 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1069534003634 Protein phosphatase 2C; Region: PP2C; pfam00481 1069534003635 active site 1069534003636 NusB family; Region: NusB; pfam01029 1069534003637 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1069534003638 putative RNA binding site [nucleotide binding]; other site 1069534003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534003640 S-adenosylmethionine binding site [chemical binding]; other site 1069534003641 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1069534003642 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1069534003643 putative active site [active] 1069534003644 substrate binding site [chemical binding]; other site 1069534003645 putative cosubstrate binding site; other site 1069534003646 catalytic site [active] 1069534003647 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1069534003648 substrate binding site [chemical binding]; other site 1069534003649 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1069534003650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1069534003651 ATP binding site [chemical binding]; other site 1069534003652 putative Mg++ binding site [ion binding]; other site 1069534003653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534003654 nucleotide binding region [chemical binding]; other site 1069534003655 ATP-binding site [chemical binding]; other site 1069534003656 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1069534003657 Flavoprotein; Region: Flavoprotein; pfam02441 1069534003658 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1069534003659 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1069534003660 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1069534003661 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1069534003662 catalytic site [active] 1069534003663 G-X2-G-X-G-K; other site 1069534003664 Similar to Bifunctional phosphoribosylaminoinidazolecarboxamide formyltransferase/IMP cycohydrolase; predicted to be non-functional du to an In frame stop codon 1069534003665 Probable transposase; Region: OrfB_IS605; pfam01385 1069534003666 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534003667 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1069534003668 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1069534003669 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1069534003670 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1069534003671 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1069534003672 DNA binding residues [nucleotide binding] 1069534003673 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1069534003674 putative dimer interface [polypeptide binding]; other site 1069534003675 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1069534003676 Aluminium resistance protein; Region: Alum_res; pfam06838 1069534003677 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1069534003678 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1069534003679 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1069534003680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1069534003681 active site residue [active] 1069534003682 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1069534003683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1069534003684 nucleotide binding site [chemical binding]; other site 1069534003685 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1069534003686 Rhomboid family; Region: Rhomboid; pfam01694 1069534003687 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1069534003688 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1069534003689 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1069534003690 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1069534003691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1069534003692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1069534003693 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1069534003694 Similar to Histidine kinase;predicted to be non-functional due to inframe stop codon 1069534003695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534003696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534003697 active site 1069534003698 phosphorylation site [posttranslational modification] 1069534003699 intermolecular recognition site; other site 1069534003700 dimerization interface [polypeptide binding]; other site 1069534003701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534003702 DNA binding site [nucleotide binding] 1069534003703 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1069534003704 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1069534003705 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1069534003706 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1069534003707 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1069534003708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534003709 Walker A motif; other site 1069534003710 ATP binding site [chemical binding]; other site 1069534003711 Walker B motif; other site 1069534003712 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1069534003713 trigger factor; Provisional; Region: tig; PRK01490 1069534003714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1069534003715 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1069534003716 elongation factor Tu; Reviewed; Region: PRK00049 1069534003717 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1069534003718 G1 box; other site 1069534003719 GEF interaction site [polypeptide binding]; other site 1069534003720 GTP/Mg2+ binding site [chemical binding]; other site 1069534003721 Switch I region; other site 1069534003722 G2 box; other site 1069534003723 G3 box; other site 1069534003724 Switch II region; other site 1069534003725 G4 box; other site 1069534003726 G5 box; other site 1069534003727 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1069534003728 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1069534003729 Antibiotic Binding Site [chemical binding]; other site 1069534003730 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1069534003731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1069534003732 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1069534003733 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1069534003734 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1069534003735 dimer interface [polypeptide binding]; other site 1069534003736 active site 1069534003737 catalytic residue [active] 1069534003738 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1069534003739 16S/18S rRNA binding site [nucleotide binding]; other site 1069534003740 S13e-L30e interaction site [polypeptide binding]; other site 1069534003741 25S rRNA binding site [nucleotide binding]; other site 1069534003742 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1069534003743 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1069534003744 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1069534003745 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1069534003746 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1069534003747 Competence protein; Region: Competence; pfam03772 1069534003748 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1069534003749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1069534003750 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1069534003751 catalytic motif [active] 1069534003752 Zn binding site [ion binding]; other site 1069534003753 SLBB domain; Region: SLBB; pfam10531 1069534003754 comEA protein; Region: comE; TIGR01259 1069534003755 Helix-hairpin-helix motif; Region: HHH; pfam00633 1069534003756 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1069534003757 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1069534003758 protein binding site [polypeptide binding]; other site 1069534003759 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1069534003760 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1069534003761 active site 1069534003762 (T/H)XGH motif; other site 1069534003763 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1069534003764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534003765 S-adenosylmethionine binding site [chemical binding]; other site 1069534003766 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1069534003767 pyruvate carboxylase; Reviewed; Region: PRK12999 1069534003768 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1069534003769 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1069534003770 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1069534003771 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1069534003772 active site 1069534003773 catalytic residues [active] 1069534003774 metal binding site [ion binding]; metal-binding site 1069534003775 homodimer binding site [polypeptide binding]; other site 1069534003776 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1069534003777 carboxyltransferase (CT) interaction site; other site 1069534003778 biotinylation site [posttranslational modification]; other site 1069534003779 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1069534003780 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1069534003781 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1069534003782 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1069534003783 G1 box; other site 1069534003784 putative GEF interaction site [polypeptide binding]; other site 1069534003785 GTP/Mg2+ binding site [chemical binding]; other site 1069534003786 Switch I region; other site 1069534003787 G2 box; other site 1069534003788 G3 box; other site 1069534003789 Switch II region; other site 1069534003790 G4 box; other site 1069534003791 G5 box; other site 1069534003792 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1069534003793 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1069534003794 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1069534003795 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1069534003796 active site 1069534003797 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1069534003798 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1069534003799 active site 1069534003800 catalytic residues [active] 1069534003801 metal binding site [ion binding]; metal-binding site 1069534003802 putative recombination protein RecB; Provisional; Region: PRK13909 1069534003803 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1069534003804 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1069534003805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1069534003806 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1069534003807 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1069534003808 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1069534003809 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1069534003810 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1069534003811 AAA domain; Region: AAA_30; pfam13604 1069534003812 Family description; Region: UvrD_C_2; pfam13538 1069534003813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1069534003814 binding surface 1069534003815 TPR motif; other site 1069534003816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534003817 catalytic core [active] 1069534003818 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1069534003819 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1069534003820 Putative amino acid metabolism; Region: DUF1831; pfam08866 1069534003821 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1069534003822 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1069534003823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1069534003824 catalytic residue [active] 1069534003825 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1069534003826 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1069534003827 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1069534003828 dimer interface [polypeptide binding]; other site 1069534003829 ADP-ribose binding site [chemical binding]; other site 1069534003830 active site 1069534003831 nudix motif; other site 1069534003832 metal binding site [ion binding]; metal-binding site 1069534003833 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1069534003834 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1069534003835 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1069534003836 Similar to Isoleucyl-tRNA synthstase; predicted to be non-functional due to framehift 1069534003837 DivIVA protein; Region: DivIVA; pfam05103 1069534003838 DivIVA domain; Region: DivI1A_domain; TIGR03544 1069534003839 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1069534003840 YGGT family; Region: YGGT; pfam02325 1069534003841 Protein of unknown function (DUF552); Region: DUF552; cl00775 1069534003842 Similar to cell division protein ftsZ; predicted to be non-functional due to frameshift 1069534003843 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1069534003844 Cell division protein FtsA; Region: FtsA; smart00842 1069534003845 Cell division protein FtsA; Region: FtsA; pfam14450 1069534003846 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1069534003847 Cell division protein FtsQ; Region: FtsQ; pfam03799 1069534003848 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1069534003849 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1069534003850 active site 1069534003851 homodimer interface [polypeptide binding]; other site 1069534003852 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1069534003853 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1069534003854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534003855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1069534003856 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1069534003857 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1069534003858 Mg++ binding site [ion binding]; other site 1069534003859 putative catalytic motif [active] 1069534003860 putative substrate binding site [chemical binding]; other site 1069534003861 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1069534003862 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1069534003863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534003864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1069534003865 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1069534003866 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1069534003867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1069534003868 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1069534003869 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1069534003870 Cell division protein FtsL; Region: FtsL; cl11433 1069534003871 MraW methylase family; Region: Methyltransf_5; pfam01795 1069534003872 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1069534003873 cell division protein MraZ; Reviewed; Region: PRK00326 1069534003874 MraZ protein; Region: MraZ; pfam02381 1069534003875 MraZ protein; Region: MraZ; pfam02381 1069534003876 aspartate kinase I; Reviewed; Region: PRK08210 1069534003877 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1069534003878 nucleotide binding site [chemical binding]; other site 1069534003879 substrate binding site [chemical binding]; other site 1069534003880 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1069534003881 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1069534003882 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1069534003883 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1069534003884 active site 1069534003885 dimer interface [polypeptide binding]; other site 1069534003886 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1069534003887 Ligand Binding Site [chemical binding]; other site 1069534003888 Molecular Tunnel; other site 1069534003889 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1069534003890 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1069534003891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1069534003892 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1069534003893 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1069534003894 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1069534003895 putative active site [active] 1069534003896 catalytic site [active] 1069534003897 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1069534003898 putative active site [active] 1069534003899 catalytic site [active] 1069534003900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1069534003901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534003902 substrate binding pocket [chemical binding]; other site 1069534003903 membrane-bound complex binding site; other site 1069534003904 hinge residues; other site 1069534003905 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534003906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534003907 Walker A/P-loop; other site 1069534003908 ATP binding site [chemical binding]; other site 1069534003909 Q-loop/lid; other site 1069534003910 ABC transporter signature motif; other site 1069534003911 Walker B; other site 1069534003912 D-loop; other site 1069534003913 H-loop/switch region; other site 1069534003914 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1069534003915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534003916 dimer interface [polypeptide binding]; other site 1069534003917 conserved gate region; other site 1069534003918 putative PBP binding loops; other site 1069534003919 ABC-ATPase subunit interface; other site 1069534003920 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1069534003921 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1069534003922 Switch I; other site 1069534003923 Switch II; other site 1069534003924 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1069534003925 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1069534003926 rod shape-determining protein MreD; Region: MreD; cl01087 1069534003927 rod shape-determining protein MreC; Provisional; Region: PRK13922 1069534003928 rod shape-determining protein MreC; Region: MreC; pfam04085 1069534003929 rod shape-determining protein MreB; Provisional; Region: PRK13927 1069534003930 MreB and similar proteins; Region: MreB_like; cd10225 1069534003931 nucleotide binding site [chemical binding]; other site 1069534003932 Mg binding site [ion binding]; other site 1069534003933 putative protofilament interaction site [polypeptide binding]; other site 1069534003934 RodZ interaction site [polypeptide binding]; other site 1069534003935 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1069534003936 DNA-binding site [nucleotide binding]; DNA binding site 1069534003937 RNA-binding motif; other site 1069534003938 hypothetical protein; Reviewed; Region: PRK00024 1069534003939 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1069534003940 MPN+ (JAMM) motif; other site 1069534003941 Zinc-binding site [ion binding]; other site 1069534003942 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1069534003943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534003944 motif II; other site 1069534003945 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1069534003946 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534003947 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1069534003948 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1069534003949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1069534003950 active site 1069534003951 HIGH motif; other site 1069534003952 nucleotide binding site [chemical binding]; other site 1069534003953 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1069534003954 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1069534003955 active site 1069534003956 KMSKS motif; other site 1069534003957 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1069534003958 tRNA binding surface [nucleotide binding]; other site 1069534003959 anticodon binding site; other site 1069534003960 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1069534003961 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1069534003962 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1069534003963 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1069534003964 Ligand Binding Site [chemical binding]; other site 1069534003965 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1069534003966 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1069534003967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1069534003968 catalytic residue [active] 1069534003969 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1069534003970 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1069534003971 GAF domain; Region: GAF_2; pfam13185 1069534003972 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1069534003973 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1069534003974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534003975 RNA binding surface [nucleotide binding]; other site 1069534003976 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1069534003977 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1069534003978 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1069534003979 recombination factor protein RarA; Reviewed; Region: PRK13342 1069534003980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534003981 Walker A motif; other site 1069534003982 ATP binding site [chemical binding]; other site 1069534003983 Walker B motif; other site 1069534003984 arginine finger; other site 1069534003985 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1069534003986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1069534003987 Ligand Binding Site [chemical binding]; other site 1069534003988 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1069534003989 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1069534003990 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1069534003991 putative active site [active] 1069534003992 catalytic site [active] 1069534003993 putative metal binding site [ion binding]; other site 1069534003994 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1069534003995 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1069534003996 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1069534003997 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1069534003998 polyphosphate kinase; Provisional; Region: PRK05443 1069534003999 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1069534004000 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1069534004001 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1069534004002 putative domain interface [polypeptide binding]; other site 1069534004003 putative active site [active] 1069534004004 catalytic site [active] 1069534004005 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1069534004006 putative domain interface [polypeptide binding]; other site 1069534004007 putative active site [active] 1069534004008 catalytic site [active] 1069534004009 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1069534004010 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1069534004011 Phosphotransferase enzyme family; Region: APH; pfam01636 1069534004012 Ecdysteroid kinase; Region: EcKinase; cl17738 1069534004013 Similar to Conserved hypothetical protein; predicted to be non-functional due to insertion of IS element 1069534004014 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534004015 MULE transposase domain; Region: MULE; pfam10551 1069534004016 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1069534004017 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1069534004018 FeS assembly protein SufB; Region: sufB; TIGR01980 1069534004019 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1069534004020 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1069534004021 trimerization site [polypeptide binding]; other site 1069534004022 active site 1069534004023 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1069534004024 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1069534004025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1069534004026 catalytic residue [active] 1069534004027 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1069534004028 FeS assembly protein SufD; Region: sufD; TIGR01981 1069534004029 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1069534004030 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1069534004031 Walker A/P-loop; other site 1069534004032 ATP binding site [chemical binding]; other site 1069534004033 Q-loop/lid; other site 1069534004034 ABC transporter signature motif; other site 1069534004035 Walker B; other site 1069534004036 D-loop; other site 1069534004037 H-loop/switch region; other site 1069534004038 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1069534004039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004040 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1069534004041 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1069534004042 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1069534004043 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534004044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004045 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1069534004046 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1069534004047 Haemolytic domain; Region: Haemolytic; cl00506 1069534004048 rod shape-determining protein MreB; Provisional; Region: PRK13930 1069534004049 MreB and similar proteins; Region: MreB_like; cd10225 1069534004050 nucleotide binding site [chemical binding]; other site 1069534004051 Mg binding site [ion binding]; other site 1069534004052 putative protofilament interaction site [polypeptide binding]; other site 1069534004053 RodZ interaction site [polypeptide binding]; other site 1069534004054 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1069534004055 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1069534004056 hinge; other site 1069534004057 active site 1069534004058 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 1069534004059 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1069534004060 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1069534004061 gamma subunit interface [polypeptide binding]; other site 1069534004062 epsilon subunit interface [polypeptide binding]; other site 1069534004063 LBP interface [polypeptide binding]; other site 1069534004064 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1069534004065 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1069534004066 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1069534004067 alpha subunit interaction interface [polypeptide binding]; other site 1069534004068 Walker A motif; other site 1069534004069 ATP binding site [chemical binding]; other site 1069534004070 Walker B motif; other site 1069534004071 inhibitor binding site; inhibition site 1069534004072 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1069534004073 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1069534004074 core domain interface [polypeptide binding]; other site 1069534004075 delta subunit interface [polypeptide binding]; other site 1069534004076 epsilon subunit interface [polypeptide binding]; other site 1069534004077 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1069534004078 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1069534004079 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1069534004080 beta subunit interaction interface [polypeptide binding]; other site 1069534004081 Walker A motif; other site 1069534004082 ATP binding site [chemical binding]; other site 1069534004083 Walker B motif; other site 1069534004084 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1069534004085 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1069534004086 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1069534004087 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1069534004088 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1069534004089 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1069534004090 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1069534004091 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1069534004092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534004093 active site 1069534004094 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1069534004095 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1069534004096 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1069534004097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534004098 S-adenosylmethionine binding site [chemical binding]; other site 1069534004099 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1069534004100 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1069534004101 RF-1 domain; Region: RF-1; pfam00472 1069534004102 thymidine kinase; Provisional; Region: PRK04296 1069534004103 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1069534004104 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1069534004105 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1069534004106 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1069534004107 catalytic triad [active] 1069534004108 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1069534004109 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1069534004110 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1069534004111 Beta-lactamase; Region: Beta-lactamase; pfam00144 1069534004112 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534004113 catalytic core [active] 1069534004114 drug efflux system protein MdtG; Provisional; Region: PRK09874 1069534004115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534004116 putative substrate translocation pore; other site 1069534004117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1069534004118 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1069534004119 Walker A/P-loop; other site 1069534004120 ATP binding site [chemical binding]; other site 1069534004121 Q-loop/lid; other site 1069534004122 ABC transporter signature motif; other site 1069534004123 Walker B; other site 1069534004124 D-loop; other site 1069534004125 H-loop/switch region; other site 1069534004126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534004127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1069534004128 substrate binding pocket [chemical binding]; other site 1069534004129 membrane-bound complex binding site; other site 1069534004130 hinge residues; other site 1069534004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004132 dimer interface [polypeptide binding]; other site 1069534004133 conserved gate region; other site 1069534004134 putative PBP binding loops; other site 1069534004135 ABC-ATPase subunit interface; other site 1069534004136 Acylphosphatase; Region: Acylphosphatase; pfam00708 1069534004137 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1069534004138 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1069534004139 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534004140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1069534004141 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1069534004142 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1069534004143 active site 1069534004144 metal binding site [ion binding]; metal-binding site 1069534004145 homotetramer interface [polypeptide binding]; other site 1069534004146 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1069534004147 active site 1069534004148 dimerization interface [polypeptide binding]; other site 1069534004149 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1069534004150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1069534004151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1069534004152 catalytic residues [active] 1069534004153 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1069534004154 MutS domain III; Region: MutS_III; pfam05192 1069534004155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534004156 Walker A/P-loop; other site 1069534004157 ATP binding site [chemical binding]; other site 1069534004158 Q-loop/lid; other site 1069534004159 ABC transporter signature motif; other site 1069534004160 Walker B; other site 1069534004161 D-loop; other site 1069534004162 H-loop/switch region; other site 1069534004163 Smr domain; Region: Smr; pfam01713 1069534004164 Colicin V production protein; Region: Colicin_V; pfam02674 1069534004165 Cell division protein ZapA; Region: ZapA; cl01146 1069534004166 hypothetical protein; Provisional; Region: PRK13678 1069534004167 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1069534004168 hypothetical protein; Provisional; Region: PRK05473 1069534004169 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1069534004170 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1069534004171 motif 1; other site 1069534004172 active site 1069534004173 motif 2; other site 1069534004174 motif 3; other site 1069534004175 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1069534004176 DHHA1 domain; Region: DHHA1; pfam02272 1069534004177 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1069534004178 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1069534004179 ATP binding site [chemical binding]; other site 1069534004180 Mg++ binding site [ion binding]; other site 1069534004181 motif III; other site 1069534004182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1069534004183 nucleotide binding region [chemical binding]; other site 1069534004184 ATP-binding site [chemical binding]; other site 1069534004185 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1069534004186 DHH family; Region: DHH; pfam01368 1069534004187 DHHA1 domain; Region: DHHA1; pfam02272 1069534004188 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1069534004189 active site 1069534004190 DNA polymerase IV; Validated; Region: PRK02406 1069534004191 DNA binding site [nucleotide binding] 1069534004192 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1069534004193 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1069534004194 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1069534004195 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1069534004196 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1069534004197 NAD binding site [chemical binding]; other site 1069534004198 homotetramer interface [polypeptide binding]; other site 1069534004199 homodimer interface [polypeptide binding]; other site 1069534004200 substrate binding site [chemical binding]; other site 1069534004201 active site 1069534004202 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1069534004203 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 1069534004204 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1069534004205 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1069534004206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1069534004207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1069534004208 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1069534004209 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1069534004210 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1069534004211 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1069534004212 carboxyltransferase (CT) interaction site; other site 1069534004213 biotinylation site [posttranslational modification]; other site 1069534004214 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1069534004215 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1069534004216 dimer interface [polypeptide binding]; other site 1069534004217 active site 1069534004218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1069534004219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1069534004220 NAD(P) binding site [chemical binding]; other site 1069534004221 active site 1069534004222 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1069534004223 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1069534004224 acyl carrier protein; Provisional; Region: acpP; PRK00982 1069534004225 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1069534004226 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1069534004227 dimer interface [polypeptide binding]; other site 1069534004228 active site 1069534004229 CoA binding pocket [chemical binding]; other site 1069534004230 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1069534004231 MarR family; Region: MarR_2; pfam12802 1069534004232 MarR family; Region: MarR_2; cl17246 1069534004233 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1069534004234 Preprotein translocase subunit; Region: YajC; pfam02699 1069534004235 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1069534004236 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1069534004237 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1069534004238 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1069534004239 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1069534004240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534004241 Walker A motif; other site 1069534004242 ATP binding site [chemical binding]; other site 1069534004243 Walker B motif; other site 1069534004244 arginine finger; other site 1069534004245 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1069534004246 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1069534004247 RuvA N terminal domain; Region: RuvA_N; pfam01330 1069534004248 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1069534004249 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1069534004250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534004251 ATP binding site [chemical binding]; other site 1069534004252 Mg2+ binding site [ion binding]; other site 1069534004253 G-X-G motif; other site 1069534004254 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1069534004255 ATP binding site [chemical binding]; other site 1069534004256 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1069534004257 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1069534004258 MutS domain I; Region: MutS_I; pfam01624 1069534004259 MutS domain II; Region: MutS_II; pfam05188 1069534004260 MutS domain III; Region: MutS_III; pfam05192 1069534004261 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1069534004262 Walker A/P-loop; other site 1069534004263 ATP binding site [chemical binding]; other site 1069534004264 Q-loop/lid; other site 1069534004265 ABC transporter signature motif; other site 1069534004266 Walker B; other site 1069534004267 D-loop; other site 1069534004268 H-loop/switch region; other site 1069534004269 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1069534004270 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1069534004271 putative active site [active] 1069534004272 metal binding site [ion binding]; metal-binding site 1069534004273 homodimer binding site [polypeptide binding]; other site 1069534004274 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534004275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534004276 DNA-binding site [nucleotide binding]; DNA binding site 1069534004277 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534004278 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1069534004279 propionate/acetate kinase; Provisional; Region: PRK12379 1069534004280 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1069534004281 Integrase core domain; Region: rve_3; cl15866 1069534004282 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1069534004283 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1069534004284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1069534004285 Ligand Binding Site [chemical binding]; other site 1069534004286 dipeptidase PepV; Reviewed; Region: PRK07318 1069534004287 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1069534004288 active site 1069534004289 metal binding site [ion binding]; metal-binding site 1069534004290 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1069534004291 putative substrate binding site [chemical binding]; other site 1069534004292 putative ATP binding site [chemical binding]; other site 1069534004293 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1069534004294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1069534004295 RNA binding surface [nucleotide binding]; other site 1069534004296 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1069534004297 active site 1069534004298 uracil binding [chemical binding]; other site 1069534004299 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1069534004300 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1069534004301 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1069534004302 HIGH motif; other site 1069534004303 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1069534004304 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1069534004305 active site 1069534004306 KMSKS motif; other site 1069534004307 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1069534004308 tRNA binding surface [nucleotide binding]; other site 1069534004309 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1069534004310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004311 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1069534004312 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004314 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1069534004315 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004316 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1069534004317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004318 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1069534004319 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004320 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1069534004321 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1069534004322 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1069534004323 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1069534004324 general stress protein 13; Validated; Region: PRK08059 1069534004325 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1069534004326 RNA binding site [nucleotide binding]; other site 1069534004327 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1069534004328 active site 1069534004329 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1069534004330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1069534004331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1069534004332 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1069534004333 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1069534004334 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1069534004335 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1069534004336 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1069534004337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534004338 active site 1069534004339 motif I; other site 1069534004340 motif II; other site 1069534004341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534004342 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1069534004343 Similar to phosphoesterase; predicted to be non-functional due to an In frame stop codon 1069534004344 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1069534004345 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1069534004346 dimer interface [polypeptide binding]; other site 1069534004347 active site 1069534004348 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1069534004349 Ligand Binding Site [chemical binding]; other site 1069534004350 Molecular Tunnel; other site 1069534004351 similar to Amino acid permease; predicted to be nonfunctional due to Frameshift 1069534004352 similar to Adenine-specific methyltransferase; predicted to be non-functional due to Frameshift 1069534004353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534004354 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1069534004355 Probable transposase; Region: OrfB_IS605; pfam01385 1069534004356 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534004357 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534004358 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1069534004359 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1069534004360 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1069534004361 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1069534004362 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1069534004363 Walker A motif; other site 1069534004364 ATP binding site [chemical binding]; other site 1069534004365 Walker B motif; other site 1069534004366 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1069534004367 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1069534004368 substrate binding site [chemical binding]; other site 1069534004369 dimer interface [polypeptide binding]; other site 1069534004370 ATP binding site [chemical binding]; other site 1069534004371 hypothetical protein; Validated; Region: PRK00110 1069534004372 Predicted integral membrane protein [Function unknown]; Region: COG5652 1069534004373 catabolite control protein A; Region: ccpA; TIGR01481 1069534004374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534004375 DNA binding site [nucleotide binding] 1069534004376 domain linker motif; other site 1069534004377 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1069534004378 dimerization interface [polypeptide binding]; other site 1069534004379 effector binding site; other site 1069534004380 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1069534004381 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1069534004382 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1069534004383 active site 1069534004384 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1069534004385 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1069534004386 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1069534004387 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1069534004388 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1069534004389 metal binding site [ion binding]; metal-binding site 1069534004390 putative dimer interface [polypeptide binding]; other site 1069534004391 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1069534004392 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1069534004393 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1069534004394 active site 1069534004395 trimer interface [polypeptide binding]; other site 1069534004396 substrate binding site [chemical binding]; other site 1069534004397 CoA binding site [chemical binding]; other site 1069534004398 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1069534004399 putative CoA binding site [chemical binding]; other site 1069534004400 putative trimer interface [polypeptide binding]; other site 1069534004401 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1069534004402 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1069534004403 amphipathic channel; other site 1069534004404 Asn-Pro-Ala signature motifs; other site 1069534004405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1069534004406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1069534004407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1069534004408 CAAX protease self-immunity; Region: Abi; pfam02517 1069534004409 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1069534004410 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1069534004411 active site 1069534004412 dimer interface [polypeptide binding]; other site 1069534004413 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1069534004414 dimer interface [polypeptide binding]; other site 1069534004415 active site 1069534004416 Sugar transport protein; Region: Sugar_transport; pfam06800 1069534004417 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1069534004418 Sulfatase; Region: Sulfatase; pfam00884 1069534004419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1069534004420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1069534004421 dimerization interface [polypeptide binding]; other site 1069534004422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1069534004423 dimer interface [polypeptide binding]; other site 1069534004424 phosphorylation site [posttranslational modification] 1069534004425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534004426 ATP binding site [chemical binding]; other site 1069534004427 Mg2+ binding site [ion binding]; other site 1069534004428 G-X-G motif; other site 1069534004429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534004430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534004431 active site 1069534004432 phosphorylation site [posttranslational modification] 1069534004433 intermolecular recognition site; other site 1069534004434 dimerization interface [polypeptide binding]; other site 1069534004435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534004436 DNA binding site [nucleotide binding] 1069534004437 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1069534004438 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1069534004439 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1069534004440 zinc binding site [ion binding]; other site 1069534004441 putative ligand binding site [chemical binding]; other site 1069534004442 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1069534004443 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1069534004444 TM-ABC transporter signature motif; other site 1069534004445 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1069534004446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534004447 Walker A/P-loop; other site 1069534004448 ATP binding site [chemical binding]; other site 1069534004449 Q-loop/lid; other site 1069534004450 ABC transporter signature motif; other site 1069534004451 Walker B; other site 1069534004452 D-loop; other site 1069534004453 H-loop/switch region; other site 1069534004454 HTH-like domain; Region: HTH_21; pfam13276 1069534004455 Integrase core domain; Region: rve; pfam00665 1069534004456 Integrase core domain; Region: rve_3; cl15866 1069534004457 Transposase; Region: HTH_Tnp_1; cl17663 1069534004458 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534004459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1069534004460 Ligand Binding Site [chemical binding]; other site 1069534004461 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1069534004462 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1069534004463 RNA/DNA hybrid binding site [nucleotide binding]; other site 1069534004464 active site 1069534004465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1069534004466 dimerization interface [polypeptide binding]; other site 1069534004467 putative DNA binding site [nucleotide binding]; other site 1069534004468 putative Zn2+ binding site [ion binding]; other site 1069534004469 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1069534004470 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1069534004471 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1069534004472 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1069534004473 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1069534004474 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1069534004475 dimerization interface [polypeptide binding]; other site 1069534004476 DPS ferroxidase diiron center [ion binding]; other site 1069534004477 ion pore; other site 1069534004478 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1069534004479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1069534004480 Walker A/P-loop; other site 1069534004481 ATP binding site [chemical binding]; other site 1069534004482 Q-loop/lid; other site 1069534004483 ABC transporter signature motif; other site 1069534004484 Walker B; other site 1069534004485 D-loop; other site 1069534004486 H-loop/switch region; other site 1069534004487 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1069534004488 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1069534004489 intersubunit interface [polypeptide binding]; other site 1069534004490 active site 1069534004491 zinc binding site [ion binding]; other site 1069534004492 Na+ binding site [ion binding]; other site 1069534004493 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1069534004494 PhoU domain; Region: PhoU; pfam01895 1069534004495 PhoU domain; Region: PhoU; pfam01895 1069534004496 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1069534004497 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1069534004498 Walker A/P-loop; other site 1069534004499 ATP binding site [chemical binding]; other site 1069534004500 Q-loop/lid; other site 1069534004501 ABC transporter signature motif; other site 1069534004502 Walker B; other site 1069534004503 D-loop; other site 1069534004504 H-loop/switch region; other site 1069534004505 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1069534004506 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1069534004507 Walker A/P-loop; other site 1069534004508 ATP binding site [chemical binding]; other site 1069534004509 Q-loop/lid; other site 1069534004510 ABC transporter signature motif; other site 1069534004511 Walker B; other site 1069534004512 D-loop; other site 1069534004513 H-loop/switch region; other site 1069534004514 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1069534004515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004516 dimer interface [polypeptide binding]; other site 1069534004517 conserved gate region; other site 1069534004518 putative PBP binding loops; other site 1069534004519 ABC-ATPase subunit interface; other site 1069534004520 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1069534004521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004522 dimer interface [polypeptide binding]; other site 1069534004523 conserved gate region; other site 1069534004524 putative PBP binding loops; other site 1069534004525 ABC-ATPase subunit interface; other site 1069534004526 PBP superfamily domain; Region: PBP_like_2; cl17296 1069534004527 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1069534004528 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1069534004529 active site 1069534004530 homodimer interface [polypeptide binding]; other site 1069534004531 catalytic site [active] 1069534004532 Similar to Glycogen phosphorylase; predicted to be ono-functional due to frameshift 1069534004533 glycogen synthase; Provisional; Region: glgA; PRK00654 1069534004534 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1069534004535 ADP-binding pocket [chemical binding]; other site 1069534004536 homodimer interface [polypeptide binding]; other site 1069534004537 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1069534004538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1069534004539 active site 1069534004540 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1069534004541 dimer interface [polypeptide binding]; other site 1069534004542 N-terminal domain interface [polypeptide binding]; other site 1069534004543 sulfate 1 binding site; other site 1069534004544 Similar to Glucose-1-phosphate adenylyltransferase; predicted to be nonfunctional due to Frameshift 1069534004545 glycogen branching enzyme; Provisional; Region: PRK12313 1069534004546 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1069534004547 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1069534004548 active site 1069534004549 catalytic site [active] 1069534004550 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1069534004551 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1069534004552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004553 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1069534004554 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1069534004555 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1069534004556 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004558 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1069534004559 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1069534004560 active site 1069534004561 substrate binding site [chemical binding]; other site 1069534004562 metal binding site [ion binding]; metal-binding site 1069534004563 YbbR-like protein; Region: YbbR; pfam07949 1069534004564 YbbR-like protein; Region: YbbR; pfam07949 1069534004565 TIGR00159 family protein; Region: TIGR00159 1069534004566 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1069534004567 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1069534004568 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1069534004569 dimer interface [polypeptide binding]; other site 1069534004570 FMN binding site [chemical binding]; other site 1069534004571 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1069534004572 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1069534004573 dimer interface [polypeptide binding]; other site 1069534004574 putative radical transfer pathway; other site 1069534004575 diiron center [ion binding]; other site 1069534004576 tyrosyl radical; other site 1069534004577 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1069534004578 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1069534004579 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1069534004580 active site 1069534004581 dimer interface [polypeptide binding]; other site 1069534004582 catalytic residues [active] 1069534004583 effector binding site; other site 1069534004584 R2 peptide binding site; other site 1069534004585 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1069534004586 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1069534004587 catalytic residues [active] 1069534004588 Cache domain; Region: Cache_1; pfam02743 1069534004589 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534004590 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534004591 dimer interface [polypeptide binding]; other site 1069534004592 putative CheW interface [polypeptide binding]; other site 1069534004593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534004594 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1069534004595 Walker A motif; other site 1069534004596 ATP binding site [chemical binding]; other site 1069534004597 Walker B motif; other site 1069534004598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1069534004599 Integrase core domain; Region: rve; pfam00665 1069534004600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534004601 H+ Antiporter protein; Region: 2A0121; TIGR00900 1069534004602 putative substrate translocation pore; other site 1069534004603 Helix-turn-helix domain; Region: HTH_38; pfam13936 1069534004604 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1069534004605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1069534004606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1069534004607 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1069534004608 Walker B motif; other site 1069534004609 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1069534004610 active site 1069534004611 nucleotide binding site [chemical binding]; other site 1069534004612 HIGH motif; other site 1069534004613 KMSKS motif; other site 1069534004614 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1069534004615 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1069534004616 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1069534004617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1069534004618 catalytic residue [active] 1069534004619 maltose O-acetyltransferase; Provisional; Region: PRK10092 1069534004620 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1069534004621 trimer interface [polypeptide binding]; other site 1069534004622 active site 1069534004623 substrate binding site [chemical binding]; other site 1069534004624 CoA binding site [chemical binding]; other site 1069534004625 LicD family; Region: LicD; cl01378 1069534004626 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1069534004627 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1069534004628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1069534004629 active site 1069534004630 Flagellar protein FliS; Region: FliS; cl00654 1069534004631 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1069534004632 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1069534004633 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1069534004634 FlaG protein; Region: FlaG; pfam03646 1069534004635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1069534004636 active site 1069534004637 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1069534004638 flagellin; Provisional; Region: PRK12804 1069534004639 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1069534004640 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1069534004641 similar to glycosyltransferase. No functional due to Frameshift 1069534004642 flagellin; Provisional; Region: PRK12804 1069534004643 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1069534004644 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1069534004645 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1069534004646 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1069534004647 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1069534004648 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1069534004649 FlgN protein; Region: FlgN; cl09176 1069534004650 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1069534004651 flagellar motor switch protein; Validated; Region: PRK08119 1069534004652 CheC-like family; Region: CheC; pfam04509 1069534004653 CheC-like family; Region: CheC; pfam04509 1069534004654 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1069534004655 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1069534004656 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1069534004657 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1069534004658 Response regulator receiver domain; Region: Response_reg; pfam00072 1069534004659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534004660 active site 1069534004661 phosphorylation site [posttranslational modification] 1069534004662 intermolecular recognition site; other site 1069534004663 dimerization interface [polypeptide binding]; other site 1069534004664 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1069534004665 CheC-like family; Region: CheC; pfam04509 1069534004666 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1069534004667 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1069534004668 putative binding surface; other site 1069534004669 active site 1069534004670 P2 response regulator binding domain; Region: P2; pfam07194 1069534004671 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1069534004672 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1069534004673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1069534004674 ATP binding site [chemical binding]; other site 1069534004675 Mg2+ binding site [ion binding]; other site 1069534004676 G-X-G motif; other site 1069534004677 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1069534004678 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1069534004679 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1069534004680 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1069534004681 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1069534004682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534004683 active site 1069534004684 phosphorylation site [posttranslational modification] 1069534004685 intermolecular recognition site; other site 1069534004686 dimerization interface [polypeptide binding]; other site 1069534004687 CheB methylesterase; Region: CheB_methylest; pfam01339 1069534004688 CheD chemotactic sensory transduction; Region: CheD; cl00810 1069534004689 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1069534004690 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534004691 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534004692 dimer interface [polypeptide binding]; other site 1069534004693 putative CheW interface [polypeptide binding]; other site 1069534004694 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1069534004695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534004696 Walker A/P-loop; other site 1069534004697 ATP binding site [chemical binding]; other site 1069534004698 Q-loop/lid; other site 1069534004699 ABC transporter signature motif; other site 1069534004700 Walker B; other site 1069534004701 D-loop; other site 1069534004702 H-loop/switch region; other site 1069534004703 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1069534004704 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1069534004705 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1069534004706 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1069534004707 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1069534004708 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1069534004709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1069534004710 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1069534004711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1069534004712 DNA binding residues [nucleotide binding] 1069534004713 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1069534004714 FHIPEP family; Region: FHIPEP; pfam00771 1069534004715 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1069534004716 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1069534004717 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 1069534004718 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1069534004719 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1069534004720 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1069534004721 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1069534004722 Flagellar protein (FlbD); Region: FlbD; pfam06289 1069534004723 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1069534004724 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1069534004725 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1069534004726 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1069534004727 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1069534004728 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1069534004729 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1069534004730 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 1069534004731 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1069534004732 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1069534004733 Walker A motif/ATP binding site; other site 1069534004734 Walker B motif; other site 1069534004735 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 1069534004736 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1069534004737 FliG C-terminal domain; Region: FliG_C; pfam01706 1069534004738 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1069534004739 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1069534004740 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1069534004741 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1069534004742 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1069534004743 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1069534004744 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1069534004745 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1069534004746 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1069534004747 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1069534004748 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1069534004749 ligand binding site [chemical binding]; other site 1069534004750 flagellar motor protein MotA; Validated; Region: PRK08124 1069534004751 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1069534004752 Cache domain; Region: Cache_1; pfam02743 1069534004753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534004754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534004755 dimer interface [polypeptide binding]; other site 1069534004756 putative CheW interface [polypeptide binding]; other site 1069534004757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1069534004758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534004759 DNA binding site [nucleotide binding] 1069534004760 domain linker motif; other site 1069534004761 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1069534004762 dimerization interface [polypeptide binding]; other site 1069534004763 ligand binding site [chemical binding]; other site 1069534004764 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1069534004765 putative active site [active] 1069534004766 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1069534004767 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1069534004768 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1069534004769 glutamate dehydrogenase; Provisional; Region: PRK09414 1069534004770 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1069534004771 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1069534004772 NAD(P) binding site [chemical binding]; other site 1069534004773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534004774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534004775 putative substrate translocation pore; other site 1069534004776 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1069534004777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534004778 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1069534004779 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1069534004780 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1069534004781 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1069534004782 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1069534004783 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1069534004784 DNA binding residues [nucleotide binding] 1069534004785 putative dimer interface [polypeptide binding]; other site 1069534004786 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1069534004787 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1069534004788 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1069534004789 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1069534004790 active site 1069534004791 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1069534004792 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1069534004793 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1069534004794 Domain of unknown function DUF21; Region: DUF21; pfam01595 1069534004795 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1069534004796 Transporter associated domain; Region: CorC_HlyC; smart01091 1069534004797 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1069534004798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004799 ABC-ATPase subunit interface; other site 1069534004800 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1069534004801 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1069534004802 Walker A/P-loop; other site 1069534004803 ATP binding site [chemical binding]; other site 1069534004804 Q-loop/lid; other site 1069534004805 ABC transporter signature motif; other site 1069534004806 Walker B; other site 1069534004807 D-loop; other site 1069534004808 H-loop/switch region; other site 1069534004809 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1069534004810 Predicted membrane protein [Function unknown]; Region: COG4905 1069534004811 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1069534004812 Peptidase family C69; Region: Peptidase_C69; pfam03577 1069534004813 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1069534004814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1069534004815 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1069534004816 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1069534004817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534004818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534004819 ABC transporter; Region: ABC_tran_2; pfam12848 1069534004820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1069534004821 Predicted permeases [General function prediction only]; Region: COG0679 1069534004822 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1069534004823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1069534004824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1069534004825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1069534004826 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1069534004827 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1069534004828 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1069534004829 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1069534004830 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1069534004831 putative active site [active] 1069534004832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1069534004833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1069534004834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1069534004835 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1069534004836 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1069534004837 active site 1069534004838 dimer interface [polypeptide binding]; other site 1069534004839 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1069534004840 active site 1069534004841 catalytic site [active] 1069534004842 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1069534004843 Part of AAA domain; Region: AAA_19; pfam13245 1069534004844 Family description; Region: UvrD_C_2; pfam13538 1069534004845 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1069534004846 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1069534004847 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1069534004848 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1069534004849 trimer interface [polypeptide binding]; other site 1069534004850 active site 1069534004851 G bulge; other site 1069534004852 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1069534004853 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1069534004854 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1069534004855 active site 1069534004856 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1069534004857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534004858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534004859 homodimer interface [polypeptide binding]; other site 1069534004860 catalytic residue [active] 1069534004861 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1069534004862 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1069534004863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004864 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1069534004865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1069534004866 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1069534004867 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1069534004868 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1069534004869 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1069534004870 hypothetical protein; Provisional; Region: PRK06446 1069534004871 metal binding site [ion binding]; metal-binding site 1069534004872 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1069534004873 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1069534004874 homodimer interface [polypeptide binding]; other site 1069534004875 substrate-cofactor binding pocket; other site 1069534004876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534004877 catalytic residue [active] 1069534004878 Similar to Amino acid transport protein; predicted to be non-functional due to Frameshift 1069534004879 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1069534004880 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1069534004881 substrate binding pocket [chemical binding]; other site 1069534004882 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1069534004883 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1069534004884 putative catalytic cysteine [active] 1069534004885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1069534004886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1069534004887 dimerization interface [polypeptide binding]; other site 1069534004888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1069534004889 dimer interface [polypeptide binding]; other site 1069534004890 phosphorylation site [posttranslational modification] 1069534004891 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1069534004892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1069534004893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534004894 active site 1069534004895 phosphorylation site [posttranslational modification] 1069534004896 intermolecular recognition site; other site 1069534004897 dimerization interface [polypeptide binding]; other site 1069534004898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1069534004899 DNA binding site [nucleotide binding] 1069534004900 chaperone protein DnaJ; Provisional; Region: PRK14288 1069534004901 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1069534004902 active site 1069534004903 catalytic residues [active] 1069534004904 metal binding site [ion binding]; metal-binding site 1069534004905 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1069534004906 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1069534004907 Walker A/P-loop; other site 1069534004908 ATP binding site [chemical binding]; other site 1069534004909 Q-loop/lid; other site 1069534004910 ABC transporter signature motif; other site 1069534004911 Walker B; other site 1069534004912 D-loop; other site 1069534004913 H-loop/switch region; other site 1069534004914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1069534004915 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1069534004916 Walker A/P-loop; other site 1069534004917 ATP binding site [chemical binding]; other site 1069534004918 Q-loop/lid; other site 1069534004919 ABC transporter signature motif; other site 1069534004920 Walker B; other site 1069534004921 D-loop; other site 1069534004922 H-loop/switch region; other site 1069534004923 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1069534004924 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1069534004925 TM-ABC transporter signature motif; other site 1069534004926 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1069534004927 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1069534004928 TM-ABC transporter signature motif; other site 1069534004929 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1069534004930 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1069534004931 putative ligand binding site [chemical binding]; other site 1069534004932 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1069534004933 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1069534004934 putative active site [active] 1069534004935 catalytic triad [active] 1069534004936 putative dimer interface [polypeptide binding]; other site 1069534004937 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1069534004938 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1069534004939 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1069534004940 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1069534004941 active site 1069534004942 catalytic site [active] 1069534004943 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1069534004944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1069534004945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1069534004946 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1069534004947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004948 dimer interface [polypeptide binding]; other site 1069534004949 conserved gate region; other site 1069534004950 putative PBP binding loops; other site 1069534004951 ABC-ATPase subunit interface; other site 1069534004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004953 dimer interface [polypeptide binding]; other site 1069534004954 conserved gate region; other site 1069534004955 putative PBP binding loops; other site 1069534004956 ABC-ATPase subunit interface; other site 1069534004957 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1069534004958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534004959 Walker A/P-loop; other site 1069534004960 ATP binding site [chemical binding]; other site 1069534004961 Q-loop/lid; other site 1069534004962 ABC transporter signature motif; other site 1069534004963 Walker B; other site 1069534004964 D-loop; other site 1069534004965 H-loop/switch region; other site 1069534004966 TOBE domain; Region: TOBE_2; pfam08402 1069534004967 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1069534004968 MULE transposase domain; Region: MULE; pfam10551 1069534004969 transaminase; Reviewed; Region: PRK08068 1069534004970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534004971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534004972 homodimer interface [polypeptide binding]; other site 1069534004973 catalytic residue [active] 1069534004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534004975 ABC-ATPase subunit interface; other site 1069534004976 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1069534004977 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1069534004978 Walker A/P-loop; other site 1069534004979 ATP binding site [chemical binding]; other site 1069534004980 Q-loop/lid; other site 1069534004981 ABC transporter signature motif; other site 1069534004982 Walker B; other site 1069534004983 D-loop; other site 1069534004984 H-loop/switch region; other site 1069534004985 NIL domain; Region: NIL; pfam09383 1069534004986 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1069534004987 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1069534004988 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1069534004989 putative active site [active] 1069534004990 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1069534004991 catalytic residues [active] 1069534004992 Class II bacteriocin; Region: Bacteriocin_II; pfam01721 1069534004993 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1069534004994 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1069534004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1069534004996 active site 1069534004997 phosphorylation site [posttranslational modification] 1069534004998 intermolecular recognition site; other site 1069534004999 LytTr DNA-binding domain; Region: LytTR; pfam04397 1069534005000 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1069534005001 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1069534005002 putative active site [active] 1069534005003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534005004 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1069534005005 Walker A/P-loop; other site 1069534005006 ATP binding site [chemical binding]; other site 1069534005007 Q-loop/lid; other site 1069534005008 ABC transporter signature motif; other site 1069534005009 Walker B; other site 1069534005010 D-loop; other site 1069534005011 H-loop/switch region; other site 1069534005012 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1069534005013 DltD N-terminal region; Region: DltD_N; pfam04915 1069534005014 DltD central region; Region: DltD_M; pfam04918 1069534005015 DltD C-terminal region; Region: DltD_C; pfam04914 1069534005016 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1069534005017 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1069534005018 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1069534005019 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1069534005020 acyl-activating enzyme (AAE) consensus motif; other site 1069534005021 AMP binding site [chemical binding]; other site 1069534005022 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1069534005023 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1069534005024 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1069534005025 NAD(P) binding site [chemical binding]; other site 1069534005026 catalytic residues [active] 1069534005027 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1069534005028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1069534005029 inhibitor-cofactor binding pocket; inhibition site 1069534005030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534005031 catalytic residue [active] 1069534005032 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1069534005033 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1069534005034 Walker A/P-loop; other site 1069534005035 ATP binding site [chemical binding]; other site 1069534005036 Q-loop/lid; other site 1069534005037 ABC transporter signature motif; other site 1069534005038 Walker B; other site 1069534005039 D-loop; other site 1069534005040 H-loop/switch region; other site 1069534005041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005042 dimer interface [polypeptide binding]; other site 1069534005043 conserved gate region; other site 1069534005044 putative PBP binding loops; other site 1069534005045 ABC-ATPase subunit interface; other site 1069534005046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1069534005047 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534005048 substrate binding pocket [chemical binding]; other site 1069534005049 membrane-bound complex binding site; other site 1069534005050 Similar to Histidinol-phosphate transaminase; predicted to be non-functional due to Frameshift 1069534005051 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1069534005052 Amidinotransferase; Region: Amidinotransf; pfam02274 1069534005053 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1069534005054 metal binding site [ion binding]; metal-binding site 1069534005055 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1069534005056 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1069534005057 NAD binding site [chemical binding]; other site 1069534005058 Amino acid permease; Region: AA_permease_2; pfam13520 1069534005059 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1069534005060 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1069534005061 substrate binding site [chemical binding]; other site 1069534005062 THF binding site; other site 1069534005063 zinc-binding site [ion binding]; other site 1069534005064 Cobalt transport protein; Region: CbiQ; cl00463 1069534005065 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1069534005066 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534005067 Walker A/P-loop; other site 1069534005068 ATP binding site [chemical binding]; other site 1069534005069 Q-loop/lid; other site 1069534005070 ABC transporter signature motif; other site 1069534005071 Walker B; other site 1069534005072 D-loop; other site 1069534005073 H-loop/switch region; other site 1069534005074 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534005075 Walker A/P-loop; other site 1069534005076 ATP binding site [chemical binding]; other site 1069534005077 ABC transporter; Region: ABC_tran; pfam00005 1069534005078 Q-loop/lid; other site 1069534005079 ABC transporter signature motif; other site 1069534005080 Walker B; other site 1069534005081 D-loop; other site 1069534005082 H-loop/switch region; other site 1069534005083 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1069534005084 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1069534005085 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1069534005086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1069534005087 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1069534005088 Walker A/P-loop; other site 1069534005089 ATP binding site [chemical binding]; other site 1069534005090 Q-loop/lid; other site 1069534005091 ABC transporter signature motif; other site 1069534005092 Walker B; other site 1069534005093 D-loop; other site 1069534005094 H-loop/switch region; other site 1069534005095 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1069534005096 NADPH bind site [chemical binding]; other site 1069534005097 putative FMN binding site [chemical binding]; other site 1069534005098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1069534005099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1069534005100 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1069534005101 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1069534005102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534005103 substrate binding pocket [chemical binding]; other site 1069534005104 membrane-bound complex binding site; other site 1069534005105 hinge residues; other site 1069534005106 Similar to ABC transporter, ATP-binding protein; predicted to be non-functional due to frameshift 1069534005107 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1069534005108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005109 dimer interface [polypeptide binding]; other site 1069534005110 conserved gate region; other site 1069534005111 putative PBP binding loops; other site 1069534005112 ABC-ATPase subunit interface; other site 1069534005113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1069534005114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534005115 putative substrate translocation pore; other site 1069534005116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005117 catalytic core [active] 1069534005118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005119 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1069534005120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1069534005121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534005122 homodimer interface [polypeptide binding]; other site 1069534005123 catalytic residue [active] 1069534005124 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1069534005125 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1069534005126 active site 1069534005127 catalytic residues [active] 1069534005128 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1069534005129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1069534005130 DNA-binding site [nucleotide binding]; DNA binding site 1069534005131 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1069534005132 putative phosphoketolase; Provisional; Region: PRK05261 1069534005133 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1069534005134 TPP-binding site; other site 1069534005135 XFP C-terminal domain; Region: XFP_C; pfam09363 1069534005136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005137 catalytic core [active] 1069534005138 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1069534005139 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1069534005140 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1069534005141 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1069534005142 peptide binding site [polypeptide binding]; other site 1069534005143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1069534005144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005145 dimer interface [polypeptide binding]; other site 1069534005146 conserved gate region; other site 1069534005147 putative PBP binding loops; other site 1069534005148 ABC-ATPase subunit interface; other site 1069534005149 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1069534005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005151 dimer interface [polypeptide binding]; other site 1069534005152 conserved gate region; other site 1069534005153 putative PBP binding loops; other site 1069534005154 ABC-ATPase subunit interface; other site 1069534005155 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1069534005156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1069534005157 Walker A/P-loop; other site 1069534005158 ATP binding site [chemical binding]; other site 1069534005159 Q-loop/lid; other site 1069534005160 ABC transporter signature motif; other site 1069534005161 Walker B; other site 1069534005162 D-loop; other site 1069534005163 H-loop/switch region; other site 1069534005164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1069534005165 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1069534005166 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1069534005167 Walker A/P-loop; other site 1069534005168 ATP binding site [chemical binding]; other site 1069534005169 Q-loop/lid; other site 1069534005170 ABC transporter signature motif; other site 1069534005171 Walker B; other site 1069534005172 D-loop; other site 1069534005173 H-loop/switch region; other site 1069534005174 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1069534005175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1069534005176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1069534005177 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1069534005178 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1069534005179 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1069534005180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1069534005181 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1069534005182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1069534005183 Similar to Transcriptional regulator; predicted to be non-functional due to frameshift 1069534005184 Similar to Efflux protein; Predicted to be non-functional due to frameshift 1069534005185 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1069534005186 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1069534005187 glutaminase active site [active] 1069534005188 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1069534005189 dimer interface [polypeptide binding]; other site 1069534005190 active site 1069534005191 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1069534005192 dimer interface [polypeptide binding]; other site 1069534005193 active site 1069534005194 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1069534005195 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1069534005196 active site 1069534005197 trimer interface [polypeptide binding]; other site 1069534005198 allosteric site; other site 1069534005199 active site lid [active] 1069534005200 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1069534005201 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1069534005202 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1069534005203 putative catalytic cysteine [active] 1069534005204 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1069534005205 putative active site [active] 1069534005206 metal binding site [ion binding]; metal-binding site 1069534005207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1069534005208 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1069534005209 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1069534005210 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1069534005211 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1069534005212 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1069534005213 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1069534005214 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1069534005215 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1069534005216 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1069534005217 amphipathic channel; other site 1069534005218 Asn-Pro-Ala signature motifs; other site 1069534005219 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1069534005220 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1069534005221 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1069534005222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1069534005223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1069534005224 active site 1069534005225 LysE type translocator; Region: LysE; cl00565 1069534005226 ornithine carbamoyltransferase; Validated; Region: PRK02102 1069534005227 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1069534005228 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1069534005229 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1069534005230 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1069534005231 inhibitor-cofactor binding pocket; inhibition site 1069534005232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1069534005233 catalytic residue [active] 1069534005234 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1069534005235 nucleotide binding site [chemical binding]; other site 1069534005236 N-acetyl-L-glutamate binding site [chemical binding]; other site 1069534005237 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1069534005238 heterotetramer interface [polypeptide binding]; other site 1069534005239 active site pocket [active] 1069534005240 cleavage site 1069534005241 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1069534005242 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1069534005243 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1069534005244 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1069534005245 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1069534005246 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1069534005247 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1069534005248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534005249 motif II; other site 1069534005250 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1069534005251 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1069534005252 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1069534005253 catalytic triad [active] 1069534005254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1069534005255 Predicted transcriptional regulator [Transcription]; Region: COG2378 1069534005256 WYL domain; Region: WYL; pfam13280 1069534005257 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1069534005258 nucleotide binding site/active site [active] 1069534005259 HIT family signature motif; other site 1069534005260 catalytic residue [active] 1069534005261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1069534005262 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1069534005263 Predicted transcriptional regulators [Transcription]; Region: COG1695 1069534005264 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1069534005265 Predicted membrane protein [Function unknown]; Region: COG2261 1069534005266 Isochorismatase family; Region: Isochorismatase; pfam00857 1069534005267 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1069534005268 catalytic triad [active] 1069534005269 conserved cis-peptide bond; other site 1069534005270 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1069534005271 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1069534005272 AIPR protein; Region: AIPR; pfam10592 1069534005273 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 1069534005274 GMP synthase; Reviewed; Region: guaA; PRK00074 1069534005275 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1069534005276 AMP/PPi binding site [chemical binding]; other site 1069534005277 candidate oxyanion hole; other site 1069534005278 catalytic triad [active] 1069534005279 potential glutamine specificity residues [chemical binding]; other site 1069534005280 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1069534005281 ATP Binding subdomain [chemical binding]; other site 1069534005282 Ligand Binding sites [chemical binding]; other site 1069534005283 Dimerization subdomain; other site 1069534005284 pantothenate kinase; Provisional; Region: PRK05439 1069534005285 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1069534005286 ATP-binding site [chemical binding]; other site 1069534005287 CoA-binding site [chemical binding]; other site 1069534005288 Mg2+-binding site [ion binding]; other site 1069534005289 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1069534005290 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1069534005291 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1069534005292 HPr interaction site; other site 1069534005293 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1069534005294 active site 1069534005295 phosphorylation site [posttranslational modification] 1069534005296 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1069534005297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1069534005298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1069534005299 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534005300 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1069534005301 Part of AAA domain; Region: AAA_19; pfam13245 1069534005302 Family description; Region: UvrD_C_2; pfam13538 1069534005303 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1069534005304 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1069534005305 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1069534005306 TrkA-N domain; Region: TrkA_N; pfam02254 1069534005307 TrkA-C domain; Region: TrkA_C; pfam02080 1069534005308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005309 catalytic core [active] 1069534005310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005311 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1069534005312 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1069534005313 LytTr DNA-binding domain; Region: LytTR; pfam04397 1069534005314 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1069534005315 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1069534005316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534005317 Walker A/P-loop; other site 1069534005318 ATP binding site [chemical binding]; other site 1069534005319 Q-loop/lid; other site 1069534005320 ABC transporter signature motif; other site 1069534005321 Walker B; other site 1069534005322 D-loop; other site 1069534005323 H-loop/switch region; other site 1069534005324 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1069534005325 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1069534005326 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1069534005327 LytTr DNA-binding domain; Region: LytTR; smart00850 1069534005328 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1069534005329 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1069534005330 Walker A/P-loop; other site 1069534005331 ATP binding site [chemical binding]; other site 1069534005332 Q-loop/lid; other site 1069534005333 ABC transporter signature motif; other site 1069534005334 Walker B; other site 1069534005335 D-loop; other site 1069534005336 H-loop/switch region; other site 1069534005337 TOBE domain; Region: TOBE_2; pfam08402 1069534005338 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1069534005339 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1069534005340 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1069534005341 nudix motif; other site 1069534005342 aspartate kinase; Reviewed; Region: PRK09034 1069534005343 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1069534005344 nucleotide binding site [chemical binding]; other site 1069534005345 substrate binding site [chemical binding]; other site 1069534005346 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1069534005347 allosteric regulatory residue; other site 1069534005348 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1069534005349 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1069534005350 GTP-binding protein YchF; Reviewed; Region: PRK09601 1069534005351 YchF GTPase; Region: YchF; cd01900 1069534005352 G1 box; other site 1069534005353 GTP/Mg2+ binding site [chemical binding]; other site 1069534005354 Switch I region; other site 1069534005355 G2 box; other site 1069534005356 Switch II region; other site 1069534005357 G3 box; other site 1069534005358 G4 box; other site 1069534005359 G5 box; other site 1069534005360 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1069534005361 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1069534005362 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1069534005363 ParB-like nuclease domain; Region: ParBc; pfam02195 1069534005364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1069534005365 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1069534005366 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1069534005367 P-loop; other site 1069534005368 Magnesium ion binding site [ion binding]; other site 1069534005369 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1069534005370 ParB-like nuclease domain; Region: ParB; smart00470 1069534005371 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1069534005372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1069534005373 S-adenosylmethionine binding site [chemical binding]; other site 1069534005374 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1069534005375 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1069534005376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1069534005377 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1069534005378 Walker A/P-loop; other site 1069534005379 ATP binding site [chemical binding]; other site 1069534005380 Q-loop/lid; other site 1069534005381 ABC transporter signature motif; other site 1069534005382 Walker B; other site 1069534005383 D-loop; other site 1069534005384 H-loop/switch region; other site 1069534005385 Similar to DNA binding protein; predicted to be non-functional due to truncation 1069534005386 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1069534005387 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1069534005388 intersubunit interface [polypeptide binding]; other site 1069534005389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1069534005390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534005391 Walker A/P-loop; other site 1069534005392 ATP binding site [chemical binding]; other site 1069534005393 Q-loop/lid; other site 1069534005394 ABC transporter signature motif; other site 1069534005395 Walker B; other site 1069534005396 D-loop; other site 1069534005397 H-loop/switch region; other site 1069534005398 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1069534005399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1069534005400 putative PBP binding regions; other site 1069534005401 ABC-ATPase subunit interface; other site 1069534005402 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1069534005403 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1069534005404 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1069534005405 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1069534005406 putative ligand binding site [chemical binding]; other site 1069534005407 putative NAD binding site [chemical binding]; other site 1069534005408 putative catalytic site [active] 1069534005409 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1069534005410 L-serine binding site [chemical binding]; other site 1069534005411 ACT domain interface; other site 1069534005412 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1069534005413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1069534005414 catalytic residue [active] 1069534005415 Similar to Cell wall-associated hydrolase; predicted to be non-functional due to frameshift 1069534005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005417 dimer interface [polypeptide binding]; other site 1069534005418 conserved gate region; other site 1069534005419 putative PBP binding loops; other site 1069534005420 ABC-ATPase subunit interface; other site 1069534005421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1069534005422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1069534005423 substrate binding pocket [chemical binding]; other site 1069534005424 membrane-bound complex binding site; other site 1069534005425 hinge residues; other site 1069534005426 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1069534005427 homodimer interface [polypeptide binding]; other site 1069534005428 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1069534005429 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1069534005430 active site 1069534005431 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1069534005432 Predicted integral membrane protein [Function unknown]; Region: COG5521 1069534005433 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1069534005434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005435 dimer interface [polypeptide binding]; other site 1069534005436 conserved gate region; other site 1069534005437 ABC-ATPase subunit interface; other site 1069534005438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005439 dimer interface [polypeptide binding]; other site 1069534005440 conserved gate region; other site 1069534005441 putative PBP binding loops; other site 1069534005442 ABC-ATPase subunit interface; other site 1069534005443 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1069534005444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1069534005445 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1069534005446 homodimer interface [polypeptide binding]; other site 1069534005447 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1069534005448 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1069534005449 active site 1069534005450 homodimer interface [polypeptide binding]; other site 1069534005451 catalytic site [active] 1069534005452 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1069534005453 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1069534005454 Ca binding site [ion binding]; other site 1069534005455 active site 1069534005456 catalytic site [active] 1069534005457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1069534005458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534005459 DNA binding site [nucleotide binding] 1069534005460 domain linker motif; other site 1069534005461 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1069534005462 ligand binding site [chemical binding]; other site 1069534005463 dimerization interface [polypeptide binding]; other site 1069534005464 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1069534005465 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1069534005466 active site turn [active] 1069534005467 phosphorylation site [posttranslational modification] 1069534005468 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1069534005469 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1069534005470 HPr interaction site; other site 1069534005471 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1069534005472 active site 1069534005473 phosphorylation site [posttranslational modification] 1069534005474 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1069534005475 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1069534005476 substrate binding [chemical binding]; other site 1069534005477 active site 1069534005478 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1069534005479 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1069534005480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534005481 DNA binding site [nucleotide binding] 1069534005482 domain linker motif; other site 1069534005483 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1069534005484 dimerization interface [polypeptide binding]; other site 1069534005485 ligand binding site [chemical binding]; other site 1069534005486 sodium binding site [ion binding]; other site 1069534005487 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1069534005488 putative catalytic site [active] 1069534005489 putative metal binding site [ion binding]; other site 1069534005490 putative phosphate binding site [ion binding]; other site 1069534005491 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1069534005492 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1069534005493 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1069534005494 active site turn [active] 1069534005495 phosphorylation site [posttranslational modification] 1069534005496 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1069534005497 HPr interaction site; other site 1069534005498 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1069534005499 active site 1069534005500 phosphorylation site [posttranslational modification] 1069534005501 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1069534005502 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1069534005503 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1069534005504 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1069534005505 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1069534005506 active pocket/dimerization site; other site 1069534005507 active site 1069534005508 phosphorylation site [posttranslational modification] 1069534005509 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1069534005510 active site 1069534005511 phosphorylation site [posttranslational modification] 1069534005512 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1069534005513 active site 1069534005514 phosphorylation site [posttranslational modification] 1069534005515 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1069534005516 active pocket/dimerization site; other site 1069534005517 active site 1069534005518 phosphorylation site [posttranslational modification] 1069534005519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1069534005520 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1069534005521 putative DNA binding site [nucleotide binding]; other site 1069534005522 putative Zn2+ binding site [ion binding]; other site 1069534005523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1069534005524 Walker A motif; other site 1069534005525 ATP binding site [chemical binding]; other site 1069534005526 Walker B motif; other site 1069534005527 arginine finger; other site 1069534005528 Transcriptional antiterminator [Transcription]; Region: COG3933 1069534005529 PRD domain; Region: PRD; pfam00874 1069534005530 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1069534005531 active pocket/dimerization site; other site 1069534005532 active site 1069534005533 phosphorylation site [posttranslational modification] 1069534005534 PRD domain; Region: PRD; pfam00874 1069534005535 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1069534005536 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1069534005537 peptide binding site [polypeptide binding]; other site 1069534005538 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1069534005539 ABC1 family; Region: ABC1; cl17513 1069534005540 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1069534005541 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1069534005542 peptide binding site [polypeptide binding]; other site 1069534005543 shikimate kinase; Reviewed; Region: aroK; PRK00131 1069534005544 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1069534005545 ADP binding site [chemical binding]; other site 1069534005546 magnesium binding site [ion binding]; other site 1069534005547 putative shikimate binding site; other site 1069534005548 prephenate dehydrogenase; Validated; Region: PRK06545 1069534005549 prephenate dehydrogenase; Validated; Region: PRK08507 1069534005550 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1069534005551 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1069534005552 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1069534005553 hinge; other site 1069534005554 active site 1069534005555 Prephenate dehydratase; Region: PDT; pfam00800 1069534005556 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1069534005557 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1069534005558 Tetramer interface [polypeptide binding]; other site 1069534005559 active site 1069534005560 FMN-binding site [chemical binding]; other site 1069534005561 Similar to Chorismate mustase; predicted to be non-functional due to truncation 1069534005562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534005563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534005564 Walker A/P-loop; other site 1069534005565 ATP binding site [chemical binding]; other site 1069534005566 Q-loop/lid; other site 1069534005567 ABC transporter signature motif; other site 1069534005568 Walker B; other site 1069534005569 D-loop; other site 1069534005570 H-loop/switch region; other site 1069534005571 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1069534005572 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1069534005573 putative dimer interface [polypeptide binding]; other site 1069534005574 Similar to HAD superfamily hydrolase; preddicted to be non-functional due to truncation 1069534005575 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1069534005576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1069534005577 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1069534005578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005579 dimer interface [polypeptide binding]; other site 1069534005580 conserved gate region; other site 1069534005581 ABC-ATPase subunit interface; other site 1069534005582 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1069534005583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1069534005584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1069534005585 putative PBP binding loops; other site 1069534005586 dimer interface [polypeptide binding]; other site 1069534005587 ABC-ATPase subunit interface; other site 1069534005588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1069534005589 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1069534005590 Walker A/P-loop; other site 1069534005591 ATP binding site [chemical binding]; other site 1069534005592 Q-loop/lid; other site 1069534005593 ABC transporter signature motif; other site 1069534005594 Walker B; other site 1069534005595 D-loop; other site 1069534005596 H-loop/switch region; other site 1069534005597 TOBE domain; Region: TOBE_2; pfam08402 1069534005598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1069534005599 dimerization interface [polypeptide binding]; other site 1069534005600 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534005601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534005602 dimer interface [polypeptide binding]; other site 1069534005603 putative CheW interface [polypeptide binding]; other site 1069534005604 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1069534005605 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1069534005606 Cache domain; Region: Cache_1; pfam02743 1069534005607 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1069534005608 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1069534005609 dimer interface [polypeptide binding]; other site 1069534005610 putative CheW interface [polypeptide binding]; other site 1069534005611 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 1069534005612 DJ-1 family protein; Region: not_thiJ; TIGR01383 1069534005613 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1069534005614 conserved cys residue [active] 1069534005615 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1069534005616 putative catalytic site [active] 1069534005617 putative metal binding site [ion binding]; other site 1069534005618 putative phosphate binding site [ion binding]; other site 1069534005619 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1069534005620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534005621 motif II; other site 1069534005622 maltose phosphorylase; Provisional; Region: PRK13807 1069534005623 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1069534005624 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1069534005625 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1069534005626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1069534005627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1069534005628 DNA binding site [nucleotide binding] 1069534005629 domain linker motif; other site 1069534005630 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1069534005631 putative dimerization interface [polypeptide binding]; other site 1069534005632 putative ligand binding site [chemical binding]; other site 1069534005633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1069534005634 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1069534005635 TM-ABC transporter signature motif; other site 1069534005636 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1069534005637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1069534005638 TM-ABC transporter signature motif; other site 1069534005639 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1069534005640 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1069534005641 Walker A/P-loop; other site 1069534005642 ATP binding site [chemical binding]; other site 1069534005643 Q-loop/lid; other site 1069534005644 ABC transporter signature motif; other site 1069534005645 Walker B; other site 1069534005646 D-loop; other site 1069534005647 H-loop/switch region; other site 1069534005648 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1069534005649 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1069534005650 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1069534005651 ligand binding site [chemical binding]; other site 1069534005652 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1069534005653 active site 1069534005654 dimerization interface [polypeptide binding]; other site 1069534005655 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1069534005656 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1069534005657 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534005658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534005659 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1069534005660 Walker A/P-loop; other site 1069534005661 ATP binding site [chemical binding]; other site 1069534005662 Q-loop/lid; other site 1069534005663 ABC transporter signature motif; other site 1069534005664 Walker B; other site 1069534005665 D-loop; other site 1069534005666 H-loop/switch region; other site 1069534005667 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1069534005668 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1069534005669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1069534005670 Walker A/P-loop; other site 1069534005671 ATP binding site [chemical binding]; other site 1069534005672 Q-loop/lid; other site 1069534005673 ABC transporter signature motif; other site 1069534005674 Walker B; other site 1069534005675 D-loop; other site 1069534005676 H-loop/switch region; other site 1069534005677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1069534005678 dimerization interface [polypeptide binding]; other site 1069534005679 putative DNA binding site [nucleotide binding]; other site 1069534005680 putative Zn2+ binding site [ion binding]; other site 1069534005681 PspC domain; Region: PspC; pfam04024 1069534005682 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1069534005683 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1069534005684 Predicted membrane protein [Function unknown]; Region: COG4709 1069534005685 Predicted transcriptional regulators [Transcription]; Region: COG1695 1069534005686 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1069534005687 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1069534005688 DNA binding residues [nucleotide binding] 1069534005689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1069534005690 putative dimer interface [polypeptide binding]; other site 1069534005691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534005692 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1069534005693 active site 1069534005694 motif I; other site 1069534005695 motif II; other site 1069534005696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1069534005697 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1069534005698 MarR family; Region: MarR; pfam01047 1069534005699 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1069534005700 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1069534005701 G-X-X-G motif; other site 1069534005702 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1069534005703 RxxxH motif; other site 1069534005704 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1069534005705 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1069534005706 active site 1069534005707 Zn binding site [ion binding]; other site 1069534005708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1069534005709 Coenzyme A binding pocket [chemical binding]; other site 1069534005710 Similar to Transposase; predicted to be non-functional due to frameshift 1069534005711 putative transposase OrfB; Reviewed; Region: PHA02517 1069534005712 HTH-like domain; Region: HTH_21; pfam13276 1069534005713 Integrase core domain; Region: rve; pfam00665 1069534005714 Integrase core domain; Region: rve_3; cl15866 1069534005715 metabolite-proton symporter; Region: 2A0106; TIGR00883 1069534005716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1069534005717 putative substrate translocation pore; other site 1069534005718 H+ Antiporter protein; Region: 2A0121; TIGR00900 1069534005719 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1069534005720 Similar to Isochorismatase hydrolase; predicted to be non-functional due to frameshift 1069534005721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1069534005722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534005723 non-specific DNA binding site [nucleotide binding]; other site 1069534005724 salt bridge; other site 1069534005725 sequence-specific DNA binding site [nucleotide binding]; other site 1069534005726 Similar to Phosphate ABC superfamily ATP binding cassette transporter, binding protein; predicted to be non-functional due to truncation 1069534005727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1069534005728 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1069534005729 Probable transposase; Region: OrfB_IS605; pfam01385 1069534005730 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1069534005731 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1069534005732 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1069534005733 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1069534005734 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1069534005735 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1069534005736 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1069534005737 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1069534005738 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1069534005739 G1 box; other site 1069534005740 GTP/Mg2+ binding site [chemical binding]; other site 1069534005741 Switch I region; other site 1069534005742 G2 box; other site 1069534005743 Switch II region; other site 1069534005744 G3 box; other site 1069534005745 G4 box; other site 1069534005746 G5 box; other site 1069534005747 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1069534005748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1069534005749 salt bridge; other site 1069534005750 non-specific DNA binding site [nucleotide binding]; other site 1069534005751 sequence-specific DNA binding site [nucleotide binding]; other site 1069534005752 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1069534005753 beta-galactosidase; Region: BGL; TIGR03356 1069534005754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005755 catalytic core [active] 1069534005756 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1069534005757 active site 1069534005758 methionine cluster; other site 1069534005759 phosphorylation site [posttranslational modification] 1069534005760 metal binding site [ion binding]; metal-binding site 1069534005761 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1069534005762 active site 1069534005763 P-loop; other site 1069534005764 phosphorylation site [posttranslational modification] 1069534005765 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1069534005766 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1069534005767 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1069534005768 beta-galactosidase; Region: BGL; TIGR03356 1069534005769 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1069534005770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1069534005771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1069534005772 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1069534005773 catalytic residues [active] 1069534005774 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1069534005775 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1069534005776 catalytic triad [active] 1069534005777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1069534005778 dimerization interface [polypeptide binding]; other site 1069534005779 putative DNA binding site [nucleotide binding]; other site 1069534005780 putative Zn2+ binding site [ion binding]; other site 1069534005781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1069534005782 active site residue [active] 1069534005783 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1069534005784 DHHA1 domain; Region: DHHA1; pfam02272 1069534005785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1069534005786 catalytic core [active] 1069534005787 Predicted flavoprotein [General function prediction only]; Region: COG0431 1069534005788 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1069534005789 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1069534005790 ApbE family; Region: ApbE; pfam02424 1069534005791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1069534005792 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534005793 Walker A/P-loop; other site 1069534005794 ATP binding site [chemical binding]; other site 1069534005795 Q-loop/lid; other site 1069534005796 ABC transporter signature motif; other site 1069534005797 Walker B; other site 1069534005798 D-loop; other site 1069534005799 H-loop/switch region; other site 1069534005800 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1069534005801 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1069534005802 Walker A/P-loop; other site 1069534005803 ATP binding site [chemical binding]; other site 1069534005804 Q-loop/lid; other site 1069534005805 ABC transporter signature motif; other site 1069534005806 Walker B; other site 1069534005807 D-loop; other site 1069534005808 H-loop/switch region; other site 1069534005809 Cobalt transport protein; Region: CbiQ; cl00463 1069534005810 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1069534005811 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1069534005812 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534005813 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1069534005814 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1069534005815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1069534005816 Transposase; Region: HTH_Tnp_1; cl17663 1069534005817 Helix-turn-helix domain; Region: HTH_28; pfam13518 1069534005818 HTH-like domain; Region: HTH_21; pfam13276 1069534005819 Integrase core domain; Region: rve; pfam00665 1069534005820 Integrase core domain; Region: rve_2; pfam13333 1069534005821 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1069534005822 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1069534005823 ribonuclease P; Reviewed; Region: rnpA; PRK00499