-- dump date 20140619_125006 -- class Genbank::misc_feature -- table misc_feature_note -- id note 712961000001 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 712961000002 nudix motif; other site 712961000003 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 712961000004 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 712961000005 active site 712961000006 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 712961000007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 712961000008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000009 P-loop; other site 712961000010 Magnesium ion binding site [ion binding]; other site 712961000011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000012 Magnesium ion binding site [ion binding]; other site 712961000013 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 712961000014 Fic/DOC family; Region: Fic; pfam02661 712961000015 MobA/MobL family; Region: MobA_MobL; pfam03389 712961000016 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 712961000017 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 712961000018 putative NAD(P) binding site [chemical binding]; other site 712961000019 dimer interface [polypeptide binding]; other site 712961000020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712961000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000022 Walker A/P-loop; other site 712961000023 ATP binding site [chemical binding]; other site 712961000024 Q-loop/lid; other site 712961000025 ABC transporter signature motif; other site 712961000026 Walker B; other site 712961000027 D-loop; other site 712961000028 H-loop/switch region; other site 712961000029 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 712961000030 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 712961000031 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712961000032 MULE transposase domain; Region: MULE; pfam10551 712961000033 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 712961000034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961000035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961000036 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961000037 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961000038 domain interaction interfaces [polypeptide binding]; other site 712961000039 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961000040 domain interaction interfaces [polypeptide binding]; other site 712961000041 potential frameshift: common BLAST hit: gi|209401040|ref|YP_002268596.1| collagen-binding A precursor protein-like protein 712961000042 Cna protein B-type domain; Region: Cna_B; pfam05738 712961000043 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961000044 domain interaction interfaces [polypeptide binding]; other site 712961000045 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961000046 Cobalt transport protein; Region: CbiQ; cl00463 712961000047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000048 Q-loop/lid; other site 712961000049 ABC transporter signature motif; other site 712961000050 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 712961000051 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712961000052 Walker A/P-loop; other site 712961000053 ATP binding site [chemical binding]; other site 712961000054 Q-loop/lid; other site 712961000055 ABC transporter signature motif; other site 712961000056 Walker B; other site 712961000057 D-loop; other site 712961000058 H-loop/switch region; other site 712961000059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000060 ABC-ATPase subunit interface; other site 712961000061 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 712961000062 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 712961000063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000064 Walker A/P-loop; other site 712961000065 ATP binding site [chemical binding]; other site 712961000066 Q-loop/lid; other site 712961000067 ABC transporter signature motif; other site 712961000068 Walker B; other site 712961000069 D-loop; other site 712961000070 H-loop/switch region; other site 712961000071 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 712961000072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961000073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961000074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961000075 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 712961000076 multiple promoter invertase; Provisional; Region: mpi; PRK13413 712961000077 catalytic residues [active] 712961000078 catalytic nucleophile [active] 712961000079 Presynaptic Site I dimer interface [polypeptide binding]; other site 712961000080 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 712961000081 Synaptic Flat tetramer interface [polypeptide binding]; other site 712961000082 Synaptic Site I dimer interface [polypeptide binding]; other site 712961000083 DNA binding site [nucleotide binding] 712961000084 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 712961000085 DNA-binding interface [nucleotide binding]; DNA binding site 712961000086 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 712961000087 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 712961000088 active site 712961000089 MobA/MobL family; Region: MobA_MobL; pfam03389 712961000090 Fic family protein [Function unknown]; Region: COG3177 712961000091 Fic/DOC family; Region: Fic; pfam02661 712961000092 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 712961000093 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 712961000094 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000095 P-loop; other site 712961000096 Magnesium ion binding site [ion binding]; other site 712961000097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000098 Magnesium ion binding site [ion binding]; other site 712961000099 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 712961000100 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 712961000101 catalytic residues [active] 712961000102 catalytic nucleophile [active] 712961000103 Presynaptic Site I dimer interface [polypeptide binding]; other site 712961000104 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 712961000105 Synaptic Flat tetramer interface [polypeptide binding]; other site 712961000106 Synaptic Site I dimer interface [polypeptide binding]; other site 712961000107 DNA binding site [nucleotide binding] 712961000108 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 712961000109 DNA-binding interface [nucleotide binding]; DNA binding site 712961000110 potential frameshift: common BLAST hit: gi|56707117|ref|YP_163747.1| putative mercury(II) reductase 712961000111 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 712961000112 TrkA-N domain; Region: TrkA_N; pfam02254 712961000113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961000114 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961000115 Asp23 family; Region: Asp23; pfam03780 712961000116 Helix-turn-helix domain; Region: HTH_28; pfam13518 712961000117 putative transposase OrfB; Reviewed; Region: PHA02517 712961000118 HTH-like domain; Region: HTH_21; pfam13276 712961000119 Integrase core domain; Region: rve; pfam00665 712961000120 Integrase core domain; Region: rve_3; pfam13683 712961000121 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712961000122 MULE transposase domain; Region: MULE; pfam10551 712961000123 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 712961000124 DnaA N-terminal domain; Region: DnaA_N; pfam11638 712961000125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961000126 Walker A motif; other site 712961000127 ATP binding site [chemical binding]; other site 712961000128 Walker B motif; other site 712961000129 arginine finger; other site 712961000130 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 712961000131 DnaA box-binding interface [nucleotide binding]; other site 712961000132 DNA polymerase III subunit beta; Validated; Region: PRK05643 712961000133 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 712961000134 putative DNA binding surface [nucleotide binding]; other site 712961000135 dimer interface [polypeptide binding]; other site 712961000136 beta-clamp/clamp loader binding surface; other site 712961000137 beta-clamp/translesion DNA polymerase binding surface; other site 712961000138 recombination protein F; Reviewed; Region: recF; PRK00064 712961000139 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 712961000140 Walker A/P-loop; other site 712961000141 ATP binding site [chemical binding]; other site 712961000142 Q-loop/lid; other site 712961000143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000144 ABC transporter signature motif; other site 712961000145 Walker B; other site 712961000146 D-loop; other site 712961000147 H-loop/switch region; other site 712961000148 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 712961000149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961000150 Mg2+ binding site [ion binding]; other site 712961000151 G-X-G motif; other site 712961000152 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 712961000153 anchoring element; other site 712961000154 dimer interface [polypeptide binding]; other site 712961000155 ATP binding site [chemical binding]; other site 712961000156 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 712961000157 active site 712961000158 putative metal-binding site [ion binding]; other site 712961000159 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 712961000160 DNA gyrase subunit A; Validated; Region: PRK05560 712961000161 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 712961000162 CAP-like domain; other site 712961000163 active site 712961000164 primary dimer interface [polypeptide binding]; other site 712961000165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961000166 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961000167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961000168 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961000169 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961000170 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 712961000171 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 712961000172 dimer interface [polypeptide binding]; other site 712961000173 ssDNA binding site [nucleotide binding]; other site 712961000174 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712961000175 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 712961000176 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 712961000177 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712961000178 active site 712961000179 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 712961000180 Peptidase family M23; Region: Peptidase_M23; pfam01551 712961000181 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 712961000182 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 712961000183 active site 712961000184 dimer interface [polypeptide binding]; other site 712961000185 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 712961000186 Ligand Binding Site [chemical binding]; other site 712961000187 Molecular Tunnel; other site 712961000188 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 712961000189 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 712961000190 PYR/PP interface [polypeptide binding]; other site 712961000191 dimer interface [polypeptide binding]; other site 712961000192 tetramer interface [polypeptide binding]; other site 712961000193 TPP binding site [chemical binding]; other site 712961000194 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 712961000195 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 712961000196 TPP-binding site [chemical binding]; other site 712961000197 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 712961000198 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712961000199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961000200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712961000201 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 712961000202 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 712961000203 aspartate racemase; Region: asp_race; TIGR00035 712961000204 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 712961000205 drug efflux system protein MdtG; Provisional; Region: PRK09874 712961000206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000207 putative substrate translocation pore; other site 712961000208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961000209 Sugar transport protein; Region: Sugar_transport; pfam06800 712961000210 Uncharacterized conserved protein [Function unknown]; Region: COG2966 712961000211 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 712961000212 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 712961000213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 712961000214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961000215 Coenzyme A binding pocket [chemical binding]; other site 712961000216 EamA-like transporter family; Region: EamA; pfam00892 712961000217 EamA-like transporter family; Region: EamA; pfam00892 712961000218 oligoendopeptidase F; Region: pepF; TIGR00181 712961000219 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 712961000220 active site 712961000221 Zn binding site [ion binding]; other site 712961000222 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 712961000223 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 712961000224 dimer interface [polypeptide binding]; other site 712961000225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961000226 catalytic residue [active] 712961000227 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 712961000228 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 712961000229 homodimer interface [polypeptide binding]; other site 712961000230 substrate-cofactor binding pocket; other site 712961000231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961000232 catalytic residue [active] 712961000233 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 712961000234 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 712961000235 active site 712961000236 NAD binding site [chemical binding]; other site 712961000237 metal binding site [ion binding]; metal-binding site 712961000238 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 712961000239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 712961000240 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961000241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000242 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 712961000243 Walker A/P-loop; other site 712961000244 ATP binding site [chemical binding]; other site 712961000245 Q-loop/lid; other site 712961000246 ABC transporter signature motif; other site 712961000247 Walker B; other site 712961000248 D-loop; other site 712961000249 H-loop/switch region; other site 712961000250 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961000251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000252 Walker A/P-loop; other site 712961000253 ATP binding site [chemical binding]; other site 712961000254 ABC transporter; Region: ABC_tran; pfam00005 712961000255 Q-loop/lid; other site 712961000256 ABC transporter signature motif; other site 712961000257 Walker B; other site 712961000258 D-loop; other site 712961000259 sugar phosphate phosphatase; Provisional; Region: PRK10513 712961000260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961000261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712961000262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961000263 active site 712961000264 phosphorylation site [posttranslational modification] 712961000265 intermolecular recognition site; other site 712961000266 dimerization interface [polypeptide binding]; other site 712961000267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712961000268 DNA binding site [nucleotide binding] 712961000269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 712961000270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 712961000271 dimerization interface [polypeptide binding]; other site 712961000272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 712961000273 putative active site [active] 712961000274 heme pocket [chemical binding]; other site 712961000275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712961000276 dimer interface [polypeptide binding]; other site 712961000277 phosphorylation site [posttranslational modification] 712961000278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961000279 ATP binding site [chemical binding]; other site 712961000280 Mg2+ binding site [ion binding]; other site 712961000281 G-X-G motif; other site 712961000282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 712961000283 YycH protein; Region: YycH; pfam07435 712961000284 YycH protein; Region: YycI; pfam09648 712961000285 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 712961000286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 712961000287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 712961000288 protein binding site [polypeptide binding]; other site 712961000289 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 712961000290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961000291 NADH(P)-binding; Region: NAD_binding_10; pfam13460 712961000292 NAD(P) binding site [chemical binding]; other site 712961000293 active site 712961000294 short chain dehydrogenase; Provisional; Region: PRK06180 712961000295 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 712961000296 NADP binding site [chemical binding]; other site 712961000297 active site 712961000298 steroid binding site; other site 712961000299 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 712961000300 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 712961000301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000302 putative substrate translocation pore; other site 712961000303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 712961000304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 712961000305 Helix-turn-helix domain; Region: HTH_28; pfam13518 712961000306 HTH-like domain; Region: HTH_21; pfam13276 712961000307 Integrase core domain; Region: rve; pfam00665 712961000308 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 712961000309 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 712961000310 putative active site [active] 712961000311 putative NTP binding site [chemical binding]; other site 712961000312 putative nucleic acid binding site [nucleotide binding]; other site 712961000313 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 712961000314 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 712961000315 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 712961000316 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712961000317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961000318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961000319 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 712961000320 active site 712961000321 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 712961000322 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 712961000323 catalytic triad [active] 712961000324 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 712961000325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961000326 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 712961000327 Walker A motif; other site 712961000328 ATP binding site [chemical binding]; other site 712961000329 Walker B motif; other site 712961000330 arginine finger; other site 712961000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961000332 Walker A motif; other site 712961000333 ATP binding site [chemical binding]; other site 712961000334 Walker B motif; other site 712961000335 arginine finger; other site 712961000336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 712961000337 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 712961000338 Ligand Binding Site [chemical binding]; other site 712961000339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961000340 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961000341 substrate binding pocket [chemical binding]; other site 712961000342 membrane-bound complex binding site; other site 712961000343 hinge residues; other site 712961000344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000345 dimer interface [polypeptide binding]; other site 712961000346 conserved gate region; other site 712961000347 ABC-ATPase subunit interface; other site 712961000348 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 712961000349 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 712961000350 homodimer interface [polypeptide binding]; other site 712961000351 substrate-cofactor binding pocket; other site 712961000352 catalytic residue [active] 712961000353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712961000354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712961000355 DNA binding site [nucleotide binding] 712961000356 domain linker motif; other site 712961000357 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 712961000358 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 712961000359 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 712961000360 substrate binding [chemical binding]; other site 712961000361 active site 712961000362 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 712961000363 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 712961000364 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 712961000365 active site turn [active] 712961000366 phosphorylation site [posttranslational modification] 712961000367 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 712961000368 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 712961000369 HPr interaction site; other site 712961000370 glycerol kinase (GK) interaction site [polypeptide binding]; other site 712961000371 active site 712961000372 phosphorylation site [posttranslational modification] 712961000373 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 712961000374 homodimer interface [polypeptide binding]; other site 712961000375 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 712961000376 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 712961000377 active site 712961000378 catalytic site [active] 712961000379 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 712961000380 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 712961000381 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 712961000382 TrkA-N domain; Region: TrkA_N; pfam02254 712961000383 TrkA-C domain; Region: TrkA_C; pfam02080 712961000384 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 712961000385 active site 712961000386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712961000387 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 712961000388 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 712961000389 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 712961000390 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 712961000391 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 712961000392 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 712961000393 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 712961000394 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 712961000395 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712961000396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961000397 active site 712961000398 motif I; other site 712961000399 motif II; other site 712961000400 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961000401 CAAX protease self-immunity; Region: Abi; pfam02517 712961000402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961000404 putative substrate translocation pore; other site 712961000405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000406 Protein of unknown function (DUF554); Region: DUF554; pfam04474 712961000407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 712961000408 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 712961000409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 712961000410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961000411 active site 712961000412 phosphorylation site [posttranslational modification] 712961000413 intermolecular recognition site; other site 712961000414 dimerization interface [polypeptide binding]; other site 712961000415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 712961000416 DNA binding residues [nucleotide binding] 712961000417 dimerization interface [polypeptide binding]; other site 712961000418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 712961000419 Histidine kinase; Region: HisKA_3; pfam07730 712961000420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961000421 ATP binding site [chemical binding]; other site 712961000422 Mg2+ binding site [ion binding]; other site 712961000423 G-X-G motif; other site 712961000424 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 712961000425 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 712961000426 ligand binding site [chemical binding]; other site 712961000427 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 712961000428 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 712961000429 active pocket/dimerization site; other site 712961000430 active site 712961000431 phosphorylation site [posttranslational modification] 712961000432 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 712961000433 active site 712961000434 phosphorylation site [posttranslational modification] 712961000435 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 712961000436 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 712961000437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961000438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961000439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961000440 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 712961000441 NlpC/P60 family; Region: NLPC_P60; pfam00877 712961000442 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 712961000443 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712961000444 catalytic residue [active] 712961000445 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 712961000446 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 712961000447 putative ligand binding site [chemical binding]; other site 712961000448 putative NAD binding site [chemical binding]; other site 712961000449 putative catalytic site [active] 712961000450 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 712961000451 L-serine binding site [chemical binding]; other site 712961000452 ACT domain interface; other site 712961000453 potential frameshift: common BLAST hit: gi|331702228|ref|YP_004399187.1| CRISPR-associated protein, Csn1 family 712961000454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 712961000455 potential frameshift: common BLAST hit: gi|331702228|ref|YP_004399187.1| CRISPR-associated protein, Csn1 family 712961000456 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 712961000457 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 712961000458 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 712961000459 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 712961000460 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 712961000461 tetramer interface [polypeptide binding]; other site 712961000462 putative DNA binding site [nucleotide binding]; other site 712961000463 Predicted membrane protein [Function unknown]; Region: COG4709 712961000464 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 712961000465 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 712961000466 glycerol kinase; Provisional; Region: glpK; PRK00047 712961000467 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 712961000468 N- and C-terminal domain interface [polypeptide binding]; other site 712961000469 active site 712961000470 MgATP binding site [chemical binding]; other site 712961000471 catalytic site [active] 712961000472 metal binding site [ion binding]; metal-binding site 712961000473 glycerol binding site [chemical binding]; other site 712961000474 homotetramer interface [polypeptide binding]; other site 712961000475 homodimer interface [polypeptide binding]; other site 712961000476 FBP binding site [chemical binding]; other site 712961000477 protein IIAGlc interface [polypeptide binding]; other site 712961000478 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 712961000479 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 712961000480 amphipathic channel; other site 712961000481 Asn-Pro-Ala signature motifs; other site 712961000482 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 712961000483 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 712961000484 Walker A/P-loop; other site 712961000485 ATP binding site [chemical binding]; other site 712961000486 Q-loop/lid; other site 712961000487 ABC transporter signature motif; other site 712961000488 Walker B; other site 712961000489 D-loop; other site 712961000490 H-loop/switch region; other site 712961000491 TOBE domain; Region: TOBE_2; pfam08402 712961000492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000493 dimer interface [polypeptide binding]; other site 712961000494 conserved gate region; other site 712961000495 putative PBP binding loops; other site 712961000496 ABC-ATPase subunit interface; other site 712961000497 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 712961000498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000499 dimer interface [polypeptide binding]; other site 712961000500 conserved gate region; other site 712961000501 ABC-ATPase subunit interface; other site 712961000502 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 712961000503 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 712961000504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 712961000505 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 712961000506 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 712961000507 zinc binding site [ion binding]; other site 712961000508 putative ligand binding site [chemical binding]; other site 712961000509 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 712961000510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 712961000511 TM-ABC transporter signature motif; other site 712961000512 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 712961000513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000514 Walker A/P-loop; other site 712961000515 ATP binding site [chemical binding]; other site 712961000516 Q-loop/lid; other site 712961000517 ABC transporter signature motif; other site 712961000518 Walker B; other site 712961000519 D-loop; other site 712961000520 H-loop/switch region; other site 712961000521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 712961000522 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 712961000523 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 712961000524 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 712961000525 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 712961000526 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 712961000527 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 712961000528 trmE is a tRNA modification GTPase; Region: trmE; cd04164 712961000529 G1 box; other site 712961000530 GTP/Mg2+ binding site [chemical binding]; other site 712961000531 Switch I region; other site 712961000532 G2 box; other site 712961000533 Switch II region; other site 712961000534 G3 box; other site 712961000535 G4 box; other site 712961000536 G5 box; other site 712961000537 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 712961000538 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 712961000539 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 712961000540 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 712961000541 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961000542 catalytic core [active] 712961000543 CAAX protease self-immunity; Region: Abi; pfam02517 712961000544 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 712961000545 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 712961000546 substrate binding site [chemical binding]; other site 712961000547 THF binding site; other site 712961000548 zinc-binding site [ion binding]; other site 712961000549 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 712961000550 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 712961000551 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 712961000552 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 712961000553 Walker A/P-loop; other site 712961000554 ATP binding site [chemical binding]; other site 712961000555 Q-loop/lid; other site 712961000556 ABC transporter signature motif; other site 712961000557 Walker B; other site 712961000558 D-loop; other site 712961000559 H-loop/switch region; other site 712961000560 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 712961000561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000562 dimer interface [polypeptide binding]; other site 712961000563 conserved gate region; other site 712961000564 ABC-ATPase subunit interface; other site 712961000565 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 712961000566 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 712961000567 metal binding site [ion binding]; metal-binding site 712961000568 dimer interface [polypeptide binding]; other site 712961000569 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 712961000570 dimer interface [polypeptide binding]; other site 712961000571 FMN binding site [chemical binding]; other site 712961000572 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 712961000573 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 712961000574 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 712961000575 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 712961000576 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 712961000577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961000578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961000579 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961000580 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 712961000581 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 712961000582 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712961000583 catalytic residue [active] 712961000584 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 712961000585 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 712961000586 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 712961000587 Walker A/P-loop; other site 712961000588 ATP binding site [chemical binding]; other site 712961000589 Q-loop/lid; other site 712961000590 ABC transporter signature motif; other site 712961000591 Walker B; other site 712961000592 D-loop; other site 712961000593 H-loop/switch region; other site 712961000594 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 712961000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961000596 dimer interface [polypeptide binding]; other site 712961000597 conserved gate region; other site 712961000598 ABC-ATPase subunit interface; other site 712961000599 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 712961000600 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 712961000601 glucose-1-dehydrogenase; Provisional; Region: PRK08936 712961000602 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 712961000603 NAD binding site [chemical binding]; other site 712961000604 homodimer interface [polypeptide binding]; other site 712961000605 active site 712961000606 Sugar transport protein; Region: Sugar_transport; pfam06800 712961000607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961000608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961000609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 712961000610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961000611 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961000612 active site 712961000613 catalytic tetrad [active] 712961000614 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 712961000615 classical (c) SDRs; Region: SDR_c; cd05233 712961000616 NAD(P) binding site [chemical binding]; other site 712961000617 active site 712961000618 Region of similarity to a putative uncharacterized protein; HN6_00128 712961000619 Region of similarity to a putative uncharacterized protein; HN6_00129 712961000620 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 712961000621 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 712961000622 tetramer interface [polypeptide binding]; other site 712961000623 TPP-binding site [chemical binding]; other site 712961000624 heterodimer interface [polypeptide binding]; other site 712961000625 phosphorylation loop region [posttranslational modification] 712961000626 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 712961000627 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 712961000628 alpha subunit interface [polypeptide binding]; other site 712961000629 TPP binding site [chemical binding]; other site 712961000630 heterodimer interface [polypeptide binding]; other site 712961000631 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 712961000632 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 712961000633 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 712961000634 E3 interaction surface; other site 712961000635 lipoyl attachment site [posttranslational modification]; other site 712961000636 e3 binding domain; Region: E3_binding; pfam02817 712961000637 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 712961000638 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 712961000639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961000640 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961000641 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 712961000642 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 712961000643 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 712961000644 Protein of unknown function (DUF975); Region: DUF975; pfam06161 712961000645 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 712961000646 active site 712961000647 catalytic triad [active] 712961000648 oxyanion hole [active] 712961000649 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 712961000650 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 712961000651 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 712961000652 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 712961000653 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 712961000654 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 712961000655 putative substrate binding site [chemical binding]; other site 712961000656 putative ATP binding site [chemical binding]; other site 712961000657 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 712961000658 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 712961000659 active site 712961000660 phosphorylation site [posttranslational modification] 712961000661 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 712961000662 active site 712961000663 P-loop; other site 712961000664 phosphorylation site [posttranslational modification] 712961000665 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 712961000666 Amino acid permease; Region: AA_permease_2; pfam13520 712961000667 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 712961000668 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961000669 EDD domain protein, DegV family; Region: DegV; TIGR00762 712961000670 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712961000671 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 712961000672 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 712961000673 Ligand binding site; other site 712961000674 Putative Catalytic site; other site 712961000675 DXD motif; other site 712961000676 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 712961000677 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 712961000678 catalytic triad [active] 712961000679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 712961000680 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 712961000681 substrate binding site [chemical binding]; other site 712961000682 oxyanion hole (OAH) forming residues; other site 712961000683 trimer interface [polypeptide binding]; other site 712961000684 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 712961000685 acyl-activating enzyme (AAE) consensus motif; other site 712961000686 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 712961000687 putative active site [active] 712961000688 putative CoA binding site [chemical binding]; other site 712961000689 putative AMP binding site [chemical binding]; other site 712961000690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 712961000691 potential frameshift: common BLAST hit: gi|90961159|ref|YP_535075.1| multidrug resistance protein B 712961000692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000694 Peptidase family C69; Region: Peptidase_C69; pfam03577 712961000695 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 712961000696 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 712961000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961000699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 712961000700 dimerization interface [polypeptide binding]; other site 712961000701 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 712961000702 active site 712961000703 acetolactate synthase; Reviewed; Region: PRK08617 712961000704 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 712961000705 PYR/PP interface [polypeptide binding]; other site 712961000706 dimer interface [polypeptide binding]; other site 712961000707 TPP binding site [chemical binding]; other site 712961000708 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 712961000709 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 712961000710 TPP-binding site [chemical binding]; other site 712961000711 dimer interface [polypeptide binding]; other site 712961000712 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 712961000713 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 712961000714 seryl-tRNA synthetase; Provisional; Region: PRK05431 712961000715 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 712961000716 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 712961000717 dimer interface [polypeptide binding]; other site 712961000718 active site 712961000719 motif 1; other site 712961000720 motif 2; other site 712961000721 motif 3; other site 712961000722 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 712961000723 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 712961000724 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 712961000725 dihydroorotase; Validated; Region: pyrC; PRK09357 712961000726 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 712961000727 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 712961000728 active site 712961000729 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 712961000730 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 712961000731 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 712961000732 catalytic site [active] 712961000733 subunit interface [polypeptide binding]; other site 712961000734 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 712961000735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712961000736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 712961000737 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 712961000738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712961000739 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712961000740 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 712961000741 IMP binding site; other site 712961000742 dimer interface [polypeptide binding]; other site 712961000743 interdomain contacts; other site 712961000744 partial ornithine binding site; other site 712961000745 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 712961000746 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 712961000747 heterodimer interface [polypeptide binding]; other site 712961000748 active site 712961000749 FMN binding site [chemical binding]; other site 712961000750 homodimer interface [polypeptide binding]; other site 712961000751 substrate binding site [chemical binding]; other site 712961000752 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 712961000753 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 712961000754 Clp amino terminal domain; Region: Clp_N; pfam02861 712961000755 Clp amino terminal domain; Region: Clp_N; pfam02861 712961000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961000757 Walker A motif; other site 712961000758 ATP binding site [chemical binding]; other site 712961000759 Walker B motif; other site 712961000760 arginine finger; other site 712961000761 UvrB/uvrC motif; Region: UVR; pfam02151 712961000762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961000763 Walker A motif; other site 712961000764 ATP binding site [chemical binding]; other site 712961000765 Walker B motif; other site 712961000766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 712961000767 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 712961000768 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 712961000769 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 712961000770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 712961000771 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 712961000772 RPB1 interaction site [polypeptide binding]; other site 712961000773 RPB10 interaction site [polypeptide binding]; other site 712961000774 RPB11 interaction site [polypeptide binding]; other site 712961000775 RPB3 interaction site [polypeptide binding]; other site 712961000776 RPB12 interaction site [polypeptide binding]; other site 712961000777 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 712961000778 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 712961000779 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 712961000780 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 712961000781 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 712961000782 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 712961000783 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 712961000784 DNA binding site [nucleotide binding] 712961000785 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 712961000786 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 712961000787 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 712961000788 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 712961000789 S17 interaction site [polypeptide binding]; other site 712961000790 S8 interaction site; other site 712961000791 16S rRNA interaction site [nucleotide binding]; other site 712961000792 streptomycin interaction site [chemical binding]; other site 712961000793 23S rRNA interaction site [nucleotide binding]; other site 712961000794 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 712961000795 elongation factor G; Reviewed; Region: PRK12739 712961000796 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 712961000797 G1 box; other site 712961000798 putative GEF interaction site [polypeptide binding]; other site 712961000799 GTP/Mg2+ binding site [chemical binding]; other site 712961000800 Switch I region; other site 712961000801 G2 box; other site 712961000802 G3 box; other site 712961000803 Switch II region; other site 712961000804 G4 box; other site 712961000805 G5 box; other site 712961000806 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 712961000807 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 712961000808 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 712961000809 NAD-dependent deacetylase; Provisional; Region: PRK00481 712961000810 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 712961000811 NAD+ binding site [chemical binding]; other site 712961000812 substrate binding site [chemical binding]; other site 712961000813 Zn binding site [ion binding]; other site 712961000814 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 712961000815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961000816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961000817 homodimer interface [polypeptide binding]; other site 712961000818 catalytic residue [active] 712961000819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712961000820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961000821 active site 712961000822 phosphorylation site [posttranslational modification] 712961000823 intermolecular recognition site; other site 712961000824 dimerization interface [polypeptide binding]; other site 712961000825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712961000826 DNA binding site [nucleotide binding] 712961000827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712961000828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 712961000829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712961000830 dimer interface [polypeptide binding]; other site 712961000831 phosphorylation site [posttranslational modification] 712961000832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961000833 ATP binding site [chemical binding]; other site 712961000834 Mg2+ binding site [ion binding]; other site 712961000835 G-X-G motif; other site 712961000836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961000837 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961000838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961000839 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961000840 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 712961000841 active site 712961000842 catalytic residues [active] 712961000843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961000844 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 712961000845 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 712961000846 TPP-binding site; other site 712961000847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 712961000848 PYR/PP interface [polypeptide binding]; other site 712961000849 dimer interface [polypeptide binding]; other site 712961000850 TPP binding site [chemical binding]; other site 712961000851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 712961000852 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961000853 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 712961000854 Walker A/P-loop; other site 712961000855 ATP binding site [chemical binding]; other site 712961000856 Q-loop/lid; other site 712961000857 ABC transporter signature motif; other site 712961000858 Walker B; other site 712961000859 D-loop; other site 712961000860 H-loop/switch region; other site 712961000861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712961000862 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 712961000863 FtsX-like permease family; Region: FtsX; pfam02687 712961000864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961000865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961000866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961000867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000868 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 712961000869 Walker A/P-loop; other site 712961000870 ATP binding site [chemical binding]; other site 712961000871 Q-loop/lid; other site 712961000872 ABC transporter signature motif; other site 712961000873 Walker B; other site 712961000874 D-loop; other site 712961000875 H-loop/switch region; other site 712961000876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 712961000877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961000878 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 712961000879 Walker A/P-loop; other site 712961000880 ATP binding site [chemical binding]; other site 712961000881 Q-loop/lid; other site 712961000882 ABC transporter signature motif; other site 712961000883 Walker B; other site 712961000884 D-loop; other site 712961000885 H-loop/switch region; other site 712961000886 TPR repeat; Region: TPR_11; pfam13414 712961000887 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 712961000888 putative ADP-ribose binding site [chemical binding]; other site 712961000889 putative active site [active] 712961000890 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 712961000891 heat shock protein HtpX; Provisional; Region: PRK04897 712961000892 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 712961000893 Part of AAA domain; Region: AAA_19; pfam13245 712961000894 Family description; Region: UvrD_C_2; pfam13538 712961000895 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 712961000896 Cation efflux family; Region: Cation_efflux; pfam01545 712961000897 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 712961000898 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 712961000899 active site 712961000900 HIGH motif; other site 712961000901 dimer interface [polypeptide binding]; other site 712961000902 KMSKS motif; other site 712961000903 exopolyphosphatase; Region: exo_poly_only; TIGR03706 712961000904 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 712961000905 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 712961000906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961000907 Walker A/P-loop; other site 712961000908 ATP binding site [chemical binding]; other site 712961000909 Q-loop/lid; other site 712961000910 ABC transporter signature motif; other site 712961000911 Walker B; other site 712961000912 D-loop; other site 712961000913 H-loop/switch region; other site 712961000914 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 712961000915 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 712961000916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961000917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961000918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961000919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961000920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961000921 substrate binding pocket [chemical binding]; other site 712961000922 membrane-bound complex binding site; other site 712961000923 hinge residues; other site 712961000924 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 712961000925 homodimer interface [polypeptide binding]; other site 712961000926 catalytic residues [active] 712961000927 NAD binding site [chemical binding]; other site 712961000928 substrate binding pocket [chemical binding]; other site 712961000929 flexible flap; other site 712961000930 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 712961000931 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 712961000932 active site 712961000933 HIGH motif; other site 712961000934 KMSKS motif; other site 712961000935 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 712961000936 tRNA binding surface [nucleotide binding]; other site 712961000937 anticodon binding site; other site 712961000938 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 712961000939 dimer interface [polypeptide binding]; other site 712961000940 putative tRNA-binding site [nucleotide binding]; other site 712961000941 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 712961000942 active site 712961000943 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 712961000944 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 712961000945 putative active site [active] 712961000946 putative metal binding site [ion binding]; other site 712961000947 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 712961000948 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 712961000949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961000950 S-adenosylmethionine binding site [chemical binding]; other site 712961000951 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 712961000952 transaminase; Validated; Region: PRK07324 712961000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961000955 homodimer interface [polypeptide binding]; other site 712961000956 catalytic residue [active] 712961000957 arginine repressor; Region: argR_whole; TIGR01529 712961000958 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 712961000959 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 712961000960 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 712961000961 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712961000962 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 712961000963 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 712961000964 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 712961000965 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961000966 Int/Topo IB signature motif; other site 712961000967 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 712961000968 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000969 P-loop; other site 712961000970 Magnesium ion binding site [ion binding]; other site 712961000971 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961000972 Magnesium ion binding site [ion binding]; other site 712961000973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961000974 non-specific DNA binding site [nucleotide binding]; other site 712961000975 salt bridge; other site 712961000976 sequence-specific DNA binding site [nucleotide binding]; other site 712961000977 Predicted transcriptional regulator [Transcription]; Region: COG2932 712961000978 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 712961000979 Catalytic site [active] 712961000980 AntA/AntB antirepressor; Region: AntA; pfam08346 712961000981 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 712961000982 Protein of unknown function (DUF968); Region: DUF968; pfam06147 712961000983 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 712961000984 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 712961000985 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 712961000986 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 712961000987 active site 712961000988 Phage terminase, small subunit; Region: Terminase_4; cl01525 712961000989 Phage Terminase; Region: Terminase_1; pfam03354 712961000990 Phage portal protein; Region: Phage_portal; pfam04860 712961000991 Phage-related protein [Function unknown]; Region: COG4695 712961000992 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 712961000993 oligomer interface [polypeptide binding]; other site 712961000994 active site residues [active] 712961000995 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 712961000996 Phage capsid family; Region: Phage_capsid; pfam05065 712961000997 Phage major tail protein; Region: Phage_tail; pfam04630 712961000998 potential frameshift: common BLAST hit: gi|90961275|ref|YP_535191.1| phage tail tape mesure 712961000999 tape measure domain; Region: tape_meas_nterm; TIGR02675 712961001000 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 712961001001 Phage tail protein; Region: Sipho_tail; pfam05709 712961001002 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712961001003 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 712961001004 Peptidase family M23; Region: Peptidase_M23; pfam01551 712961001005 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712961001006 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 712961001007 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 712961001008 active site 712961001009 potential frameshift: common BLAST hit: gi|90961776|ref|YP_535692.1| phage minor head protein 712961001010 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 712961001011 active site 712961001012 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961001013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961001014 argininosuccinate lyase; Provisional; Region: PRK00855 712961001015 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 712961001016 active sites [active] 712961001017 tetramer interface [polypeptide binding]; other site 712961001018 argininosuccinate synthase; Provisional; Region: PRK13820 712961001019 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 712961001020 ANP binding site [chemical binding]; other site 712961001021 Substrate Binding Site II [chemical binding]; other site 712961001022 Substrate Binding Site I [chemical binding]; other site 712961001023 aromatic amino acid aminotransferase; Validated; Region: PRK07309 712961001024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961001025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961001026 homodimer interface [polypeptide binding]; other site 712961001027 catalytic residue [active] 712961001028 D-lactate dehydrogenase; Validated; Region: PRK08605 712961001029 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 712961001030 homodimer interface [polypeptide binding]; other site 712961001031 ligand binding site [chemical binding]; other site 712961001032 NAD binding site [chemical binding]; other site 712961001033 catalytic site [active] 712961001034 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 712961001035 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 712961001036 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001037 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001038 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001039 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001040 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001041 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001042 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001043 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001045 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001046 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 712961001047 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 712961001048 pur operon repressor; Provisional; Region: PRK09213 712961001049 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 712961001050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961001051 active site 712961001052 H+ Antiporter protein; Region: 2A0121; TIGR00900 712961001053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961001054 putative substrate translocation pore; other site 712961001055 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 712961001056 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 712961001057 Substrate binding site; other site 712961001058 Mg++ binding site; other site 712961001059 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 712961001060 active site 712961001061 substrate binding site [chemical binding]; other site 712961001062 CoA binding site [chemical binding]; other site 712961001063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 712961001064 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 712961001065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961001066 active site 712961001067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 712961001068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961001069 Coenzyme A binding pocket [chemical binding]; other site 712961001070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961001071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961001072 active site 712961001073 catalytic tetrad [active] 712961001074 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 712961001075 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 712961001076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961001077 Walker A/P-loop; other site 712961001078 ATP binding site [chemical binding]; other site 712961001079 Q-loop/lid; other site 712961001080 ABC transporter signature motif; other site 712961001081 Walker B; other site 712961001082 D-loop; other site 712961001083 H-loop/switch region; other site 712961001084 ABC transporter; Region: ABC_tran_2; pfam12848 712961001085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961001086 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 712961001087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 712961001088 Biotin operon repressor [Transcription]; Region: BirA; COG1654 712961001089 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 712961001090 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 712961001091 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 712961001092 YibE/F-like protein; Region: YibE_F; pfam07907 712961001093 YibE/F-like protein; Region: YibE_F; pfam07907 712961001094 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 712961001095 stage V sporulation protein K; Region: spore_V_K; TIGR02881 712961001096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961001097 Walker A motif; other site 712961001098 ATP binding site [chemical binding]; other site 712961001099 Walker B motif; other site 712961001100 arginine finger; other site 712961001101 AAA domain; Region: AAA_30; pfam13604 712961001102 Family description; Region: UvrD_C_2; pfam13538 712961001103 Protein of unknown function, DUF606; Region: DUF606; pfam04657 712961001104 sugar phosphate phosphatase; Provisional; Region: PRK10513 712961001105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961001106 active site 712961001107 motif I; other site 712961001108 motif II; other site 712961001109 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961001110 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 712961001111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961001112 Zn2+ binding site [ion binding]; other site 712961001113 Mg2+ binding site [ion binding]; other site 712961001114 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 712961001115 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 712961001116 catalytic triad [active] 712961001117 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 712961001118 CTP synthetase; Validated; Region: pyrG; PRK05380 712961001119 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 712961001120 Catalytic site [active] 712961001121 active site 712961001122 UTP binding site [chemical binding]; other site 712961001123 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 712961001124 active site 712961001125 putative oxyanion hole; other site 712961001126 catalytic triad [active] 712961001127 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 712961001128 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 712961001129 hinge; other site 712961001130 active site 712961001131 transcription termination factor Rho; Provisional; Region: rho; PRK09376 712961001132 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 712961001133 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 712961001134 RNA binding site [nucleotide binding]; other site 712961001135 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 712961001136 multimer interface [polypeptide binding]; other site 712961001137 Walker A motif; other site 712961001138 ATP binding site [chemical binding]; other site 712961001139 Walker B motif; other site 712961001140 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 712961001141 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 712961001142 DEAD/DEAH box helicase; Region: DEAD; pfam00270 712961001143 DEAD_2; Region: DEAD_2; pfam06733 712961001144 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 712961001145 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 712961001146 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 712961001147 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 712961001148 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 712961001149 TIGR02452 family protein; Region: TIGR02452 712961001150 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 712961001151 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712961001152 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961001153 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712961001154 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 712961001155 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712961001156 ATP binding site [chemical binding]; other site 712961001157 Mg++ binding site [ion binding]; other site 712961001158 motif III; other site 712961001159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961001160 nucleotide binding region [chemical binding]; other site 712961001161 ATP-binding site [chemical binding]; other site 712961001162 alanine racemase; Reviewed; Region: alr; PRK00053 712961001163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 712961001164 active site 712961001165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 712961001166 dimer interface [polypeptide binding]; other site 712961001167 substrate binding site [chemical binding]; other site 712961001168 catalytic residues [active] 712961001169 Protein of unknown function DUF72; Region: DUF72; pfam01904 712961001170 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 712961001171 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 712961001172 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 712961001173 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 712961001174 recombination regulator RecX; Provisional; Region: recX; PRK14135 712961001175 TRAM domain; Region: TRAM; pfam01938 712961001176 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 712961001177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001178 S-adenosylmethionine binding site [chemical binding]; other site 712961001179 hypothetical protein; Provisional; Region: PRK13662 712961001180 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 712961001181 Domain of unknown function DUF20; Region: UPF0118; pfam01594 712961001182 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 712961001183 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 712961001184 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 712961001185 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 712961001186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961001187 Walker A/P-loop; other site 712961001188 ATP binding site [chemical binding]; other site 712961001189 Q-loop/lid; other site 712961001190 ABC transporter signature motif; other site 712961001191 Walker B; other site 712961001192 D-loop; other site 712961001193 H-loop/switch region; other site 712961001194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961001195 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 712961001196 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 712961001197 G1 box; other site 712961001198 putative GEF interaction site [polypeptide binding]; other site 712961001199 GTP/Mg2+ binding site [chemical binding]; other site 712961001200 Switch I region; other site 712961001201 G2 box; other site 712961001202 G3 box; other site 712961001203 Switch II region; other site 712961001204 G4 box; other site 712961001205 G5 box; other site 712961001206 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 712961001207 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 712961001208 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 712961001209 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 712961001210 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 712961001211 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 712961001212 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 712961001213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001214 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961001216 putative substrate translocation pore; other site 712961001217 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 712961001218 HPr interaction site; other site 712961001219 glycerol kinase (GK) interaction site [polypeptide binding]; other site 712961001220 active site 712961001221 phosphorylation site [posttranslational modification] 712961001222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712961001223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712961001224 DNA binding site [nucleotide binding] 712961001225 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 712961001226 putative ligand binding site [chemical binding]; other site 712961001227 putative dimerization interface [polypeptide binding]; other site 712961001228 galactokinase; Provisional; Region: PRK05322 712961001229 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 712961001230 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712961001231 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 712961001232 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 712961001233 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 712961001234 NAD binding site [chemical binding]; other site 712961001235 homodimer interface [polypeptide binding]; other site 712961001236 active site 712961001237 substrate binding site [chemical binding]; other site 712961001238 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 712961001239 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 712961001240 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 712961001241 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 712961001242 Melibiase; Region: Melibiase; pfam02065 712961001243 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001244 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 712961001245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961001246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 712961001247 Walker A motif; other site 712961001248 ATP binding site [chemical binding]; other site 712961001249 Walker B motif; other site 712961001250 arginine finger; other site 712961001251 UvrB/uvrC motif; Region: UVR; pfam02151 712961001252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961001253 Walker A motif; other site 712961001254 ATP binding site [chemical binding]; other site 712961001255 Walker B motif; other site 712961001256 arginine finger; other site 712961001257 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 712961001258 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 712961001259 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 712961001260 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 712961001261 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 712961001262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961001263 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 712961001264 putative ADP-binding pocket [chemical binding]; other site 712961001265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961001266 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961001267 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 712961001268 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 712961001269 Sulfatase; Region: Sulfatase; pfam00884 712961001270 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 712961001271 active site 712961001272 nucleotide-binding site [chemical binding]; other site 712961001273 adaptor protein; Provisional; Region: PRK02315 712961001274 Competence protein CoiA-like family; Region: CoiA; cl11541 712961001275 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 712961001276 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 712961001277 active site 712961001278 Zn binding site [ion binding]; other site 712961001279 Thioredoxin; Region: Thioredoxin_5; pfam13743 712961001280 PBP superfamily domain; Region: PBP_like_2; cl17296 712961001281 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 712961001282 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 712961001283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961001284 dimer interface [polypeptide binding]; other site 712961001285 conserved gate region; other site 712961001286 putative PBP binding loops; other site 712961001287 ABC-ATPase subunit interface; other site 712961001288 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 712961001289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961001290 dimer interface [polypeptide binding]; other site 712961001291 conserved gate region; other site 712961001292 putative PBP binding loops; other site 712961001293 ABC-ATPase subunit interface; other site 712961001294 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 712961001295 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 712961001296 Walker A/P-loop; other site 712961001297 ATP binding site [chemical binding]; other site 712961001298 Q-loop/lid; other site 712961001299 ABC transporter signature motif; other site 712961001300 Walker B; other site 712961001301 D-loop; other site 712961001302 H-loop/switch region; other site 712961001303 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 712961001304 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 712961001305 Walker A/P-loop; other site 712961001306 ATP binding site [chemical binding]; other site 712961001307 Q-loop/lid; other site 712961001308 ABC transporter signature motif; other site 712961001309 Walker B; other site 712961001310 D-loop; other site 712961001311 H-loop/switch region; other site 712961001312 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 712961001313 PhoU domain; Region: PhoU; pfam01895 712961001314 PhoU domain; Region: PhoU; pfam01895 712961001315 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 712961001316 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 712961001317 intersubunit interface [polypeptide binding]; other site 712961001318 active site 712961001319 zinc binding site [ion binding]; other site 712961001320 Na+ binding site [ion binding]; other site 712961001321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001322 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001323 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 712961001324 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 712961001325 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 712961001326 Haemolysin-III related; Region: HlyIII; cl03831 712961001327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001328 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001329 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 712961001330 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 712961001331 RNA/DNA hybrid binding site [nucleotide binding]; other site 712961001332 active site 712961001333 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 712961001334 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 712961001335 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 712961001336 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 712961001337 active site 712961001338 catabolite control protein A; Region: ccpA; TIGR01481 712961001339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712961001340 DNA binding site [nucleotide binding] 712961001341 domain linker motif; other site 712961001342 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 712961001343 dimerization interface [polypeptide binding]; other site 712961001344 effector binding site; other site 712961001345 Predicted integral membrane protein [Function unknown]; Region: COG5652 712961001346 hypothetical protein; Validated; Region: PRK00110 712961001347 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 712961001348 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 712961001349 substrate binding site [chemical binding]; other site 712961001350 dimer interface [polypeptide binding]; other site 712961001351 ATP binding site [chemical binding]; other site 712961001352 Type II/IV secretion system protein; Region: T2SE; pfam00437 712961001353 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 712961001354 Walker A motif; other site 712961001355 ATP binding site [chemical binding]; other site 712961001356 Walker B motif; other site 712961001357 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 712961001358 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 712961001359 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 712961001360 Methyltransferase domain; Region: Methyltransf_26; pfam13659 712961001361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001362 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001363 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712961001364 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 712961001365 putative active site [active] 712961001366 putative metal binding site [ion binding]; other site 712961001367 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 712961001368 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 712961001369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961001370 active site 712961001371 motif I; other site 712961001372 motif II; other site 712961001373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961001374 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 712961001375 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 712961001376 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 712961001377 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 712961001378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961001379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961001380 S-adenosylmethionine synthetase; Validated; Region: PRK05250 712961001381 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 712961001382 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 712961001383 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 712961001384 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 712961001385 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 712961001386 HIGH motif; other site 712961001387 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 712961001388 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 712961001389 active site 712961001390 KMSKS motif; other site 712961001391 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 712961001392 tRNA binding surface [nucleotide binding]; other site 712961001393 potential frameshift: common BLAST hit: gi|90961420|ref|YP_535336.1| amino acid permease 712961001394 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712961001395 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712961001396 stage V sporulation protein B; Region: spore_V_B; TIGR02900 712961001397 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 712961001398 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 712961001399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961001400 RNA binding surface [nucleotide binding]; other site 712961001401 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 712961001402 active site 712961001403 uracil binding [chemical binding]; other site 712961001404 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 712961001405 putative substrate binding site [chemical binding]; other site 712961001406 putative ATP binding site [chemical binding]; other site 712961001407 dipeptidase PepV; Reviewed; Region: PRK07318 712961001408 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 712961001409 active site 712961001410 metal binding site [ion binding]; metal-binding site 712961001411 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 712961001412 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 712961001413 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 712961001414 dimer interface [polypeptide binding]; other site 712961001415 active site 712961001416 CoA binding pocket [chemical binding]; other site 712961001417 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 712961001418 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 712961001419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 712961001420 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 712961001421 NAD(P) binding site [chemical binding]; other site 712961001422 homotetramer interface [polypeptide binding]; other site 712961001423 homodimer interface [polypeptide binding]; other site 712961001424 active site 712961001425 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 712961001426 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 712961001427 dimer interface [polypeptide binding]; other site 712961001428 active site 712961001429 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 712961001430 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712961001431 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712961001432 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 712961001433 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 712961001434 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 712961001435 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 712961001436 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 712961001437 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 712961001438 NAD binding site [chemical binding]; other site 712961001439 homotetramer interface [polypeptide binding]; other site 712961001440 homodimer interface [polypeptide binding]; other site 712961001441 substrate binding site [chemical binding]; other site 712961001442 active site 712961001443 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 712961001444 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 712961001445 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 712961001446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001447 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001448 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 712961001449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 712961001450 active site 712961001451 dimer interface [polypeptide binding]; other site 712961001452 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 712961001453 dimer interface [polypeptide binding]; other site 712961001454 active site 712961001455 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 712961001456 Sulfatase; Region: Sulfatase; pfam00884 712961001457 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 712961001458 amphipathic channel; other site 712961001459 Asn-Pro-Ala signature motifs; other site 712961001460 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 712961001461 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 712961001462 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 712961001463 active site 712961001464 trimer interface [polypeptide binding]; other site 712961001465 substrate binding site [chemical binding]; other site 712961001466 CoA binding site [chemical binding]; other site 712961001467 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 712961001468 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 712961001469 metal binding site [ion binding]; metal-binding site 712961001470 putative dimer interface [polypeptide binding]; other site 712961001471 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 712961001472 Mechanosensitive ion channel; Region: MS_channel; pfam00924 712961001473 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 712961001474 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 712961001475 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 712961001476 Transglycosylase; Region: Transgly; pfam00912 712961001477 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 712961001478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 712961001479 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 712961001480 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 712961001481 generic binding surface I; other site 712961001482 generic binding surface II; other site 712961001483 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 712961001484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961001485 Zn2+ binding site [ion binding]; other site 712961001486 Mg2+ binding site [ion binding]; other site 712961001487 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 712961001488 SurA N-terminal domain; Region: SurA_N_3; cl07813 712961001489 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 712961001490 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 712961001491 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 712961001492 Walker A/P-loop; other site 712961001493 ATP binding site [chemical binding]; other site 712961001494 Q-loop/lid; other site 712961001495 ABC transporter signature motif; other site 712961001496 Walker B; other site 712961001497 D-loop; other site 712961001498 H-loop/switch region; other site 712961001499 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 712961001500 Phosphotransferase enzyme family; Region: APH; pfam01636 712961001501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 712961001502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001503 S-adenosylmethionine binding site [chemical binding]; other site 712961001504 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 712961001505 putative tRNA-binding site [nucleotide binding]; other site 712961001506 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 712961001507 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 712961001508 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 712961001509 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 712961001510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712961001511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961001512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712961001513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 712961001514 active site 2 [active] 712961001515 active site 1 [active] 712961001516 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 712961001517 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 712961001518 DNA polymerase I; Provisional; Region: PRK05755 712961001519 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 712961001520 active site 712961001521 metal binding site 1 [ion binding]; metal-binding site 712961001522 putative 5' ssDNA interaction site; other site 712961001523 metal binding site 3; metal-binding site 712961001524 metal binding site 2 [ion binding]; metal-binding site 712961001525 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 712961001526 putative DNA binding site [nucleotide binding]; other site 712961001527 putative metal binding site [ion binding]; other site 712961001528 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 712961001529 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 712961001530 active site 712961001531 DNA binding site [nucleotide binding] 712961001532 catalytic site [active] 712961001533 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 712961001534 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 712961001535 DNA binding site [nucleotide binding] 712961001536 turnover-facilitating residue; other site 712961001537 intercalation triad [nucleotide binding]; other site 712961001538 8OG recognition residue [nucleotide binding]; other site 712961001539 putative reading head residues; other site 712961001540 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 712961001541 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 712961001542 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 712961001543 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 712961001544 CoA-binding site [chemical binding]; other site 712961001545 ATP-binding [chemical binding]; other site 712961001546 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 712961001547 ATP cone domain; Region: ATP-cone; pfam03477 712961001548 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 712961001549 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 712961001550 primosomal protein DnaI; Reviewed; Region: PRK08939 712961001551 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 712961001552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961001553 Walker A motif; other site 712961001554 ATP binding site [chemical binding]; other site 712961001555 Walker B motif; other site 712961001556 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 712961001557 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 712961001558 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 712961001559 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 712961001560 active site 712961001561 dimer interface [polypeptide binding]; other site 712961001562 motif 1; other site 712961001563 motif 2; other site 712961001564 motif 3; other site 712961001565 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 712961001566 anticodon binding site; other site 712961001567 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 712961001568 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 712961001569 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 712961001570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001571 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001572 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 712961001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961001574 active site 712961001575 motif I; other site 712961001576 motif II; other site 712961001577 GTPase YqeH; Provisional; Region: PRK13796 712961001578 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 712961001579 GTP/Mg2+ binding site [chemical binding]; other site 712961001580 G4 box; other site 712961001581 G5 box; other site 712961001582 G1 box; other site 712961001583 Switch I region; other site 712961001584 G2 box; other site 712961001585 G3 box; other site 712961001586 Switch II region; other site 712961001587 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 712961001588 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 712961001589 active site 712961001590 (T/H)XGH motif; other site 712961001591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961001592 Zn2+ binding site [ion binding]; other site 712961001593 Mg2+ binding site [ion binding]; other site 712961001594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001595 hypothetical protein; Provisional; Region: PRK13670 712961001596 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 712961001597 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 712961001598 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 712961001599 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 712961001600 putative acyl-acceptor binding pocket; other site 712961001601 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 712961001602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001603 S-adenosylmethionine binding site [chemical binding]; other site 712961001604 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 712961001605 rRNA interaction site [nucleotide binding]; other site 712961001606 S8 interaction site; other site 712961001607 putative laminin-1 binding site; other site 712961001608 elongation factor Ts; Provisional; Region: tsf; PRK09377 712961001609 UBA/TS-N domain; Region: UBA; pfam00627 712961001610 Elongation factor TS; Region: EF_TS; pfam00889 712961001611 Elongation factor TS; Region: EF_TS; pfam00889 712961001612 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 712961001613 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 712961001614 Substrate-binding site [chemical binding]; other site 712961001615 Substrate specificity [chemical binding]; other site 712961001616 AIR carboxylase; Region: AIRC; pfam00731 712961001617 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 712961001618 ATP-grasp domain; Region: ATP-grasp; pfam02222 712961001619 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 712961001620 tetramer interface [polypeptide binding]; other site 712961001621 active site 712961001622 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 712961001623 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 712961001624 active site 712961001625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712961001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961001627 active site 712961001628 phosphorylation site [posttranslational modification] 712961001629 intermolecular recognition site; other site 712961001630 dimerization interface [polypeptide binding]; other site 712961001631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712961001632 DNA binding site [nucleotide binding] 712961001633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712961001634 HAMP domain; Region: HAMP; pfam00672 712961001635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712961001636 dimer interface [polypeptide binding]; other site 712961001637 phosphorylation site [posttranslational modification] 712961001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961001639 ATP binding site [chemical binding]; other site 712961001640 Mg2+ binding site [ion binding]; other site 712961001641 G-X-G motif; other site 712961001642 OxaA-like protein precursor; Provisional; Region: PRK02463 712961001643 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 712961001644 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 712961001645 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 712961001646 dimer interface [polypeptide binding]; other site 712961001647 active site 712961001648 elongation factor P; Validated; Region: PRK00529 712961001649 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 712961001650 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 712961001651 RNA binding site [nucleotide binding]; other site 712961001652 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 712961001653 RNA binding site [nucleotide binding]; other site 712961001654 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 712961001655 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 712961001656 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 712961001657 homodimer interface [polypeptide binding]; other site 712961001658 NADP binding site [chemical binding]; other site 712961001659 substrate binding site [chemical binding]; other site 712961001660 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 712961001661 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 712961001662 generic binding surface II; other site 712961001663 generic binding surface I; other site 712961001664 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 712961001665 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 712961001666 substrate binding pocket [chemical binding]; other site 712961001667 chain length determination region; other site 712961001668 substrate-Mg2+ binding site; other site 712961001669 catalytic residues [active] 712961001670 aspartate-rich region 1; other site 712961001671 active site lid residues [active] 712961001672 aspartate-rich region 2; other site 712961001673 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 712961001674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961001675 RNA binding surface [nucleotide binding]; other site 712961001676 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 712961001677 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 712961001678 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 712961001679 Walker A/P-loop; other site 712961001680 ATP binding site [chemical binding]; other site 712961001681 Q-loop/lid; other site 712961001682 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 712961001683 ABC transporter signature motif; other site 712961001684 Walker B; other site 712961001685 D-loop; other site 712961001686 H-loop/switch region; other site 712961001687 LexA repressor; Validated; Region: PRK00215 712961001688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 712961001689 putative DNA binding site [nucleotide binding]; other site 712961001690 putative Zn2+ binding site [ion binding]; other site 712961001691 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 712961001692 Catalytic site [active] 712961001693 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 712961001694 G1 box; other site 712961001695 GTP/Mg2+ binding site [chemical binding]; other site 712961001696 Switch I region; other site 712961001697 G2 box; other site 712961001698 G3 box; other site 712961001699 Switch II region; other site 712961001700 G4 box; other site 712961001701 G5 box; other site 712961001702 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 712961001703 Helix-turn-helix domain; Region: HTH_28; pfam13518 712961001704 putative transposase OrfB; Reviewed; Region: PHA02517 712961001705 HTH-like domain; Region: HTH_21; pfam13276 712961001706 Integrase core domain; Region: rve; pfam00665 712961001707 Integrase core domain; Region: rve_3; pfam13683 712961001708 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 712961001709 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 712961001710 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 712961001711 Rhomboid family; Region: Rhomboid; pfam01694 712961001712 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 712961001713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712961001714 nucleotide binding site [chemical binding]; other site 712961001715 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 712961001716 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 712961001717 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 712961001718 Aluminium resistance protein; Region: Alum_res; pfam06838 712961001719 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 712961001720 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 712961001721 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 712961001722 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 712961001723 putative nucleotide binding site [chemical binding]; other site 712961001724 uridine monophosphate binding site [chemical binding]; other site 712961001725 homohexameric interface [polypeptide binding]; other site 712961001726 ribosome recycling factor; Reviewed; Region: frr; PRK00083 712961001727 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 712961001728 hinge region; other site 712961001729 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 712961001730 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 712961001731 catalytic residue [active] 712961001732 putative FPP diphosphate binding site; other site 712961001733 putative FPP binding hydrophobic cleft; other site 712961001734 dimer interface [polypeptide binding]; other site 712961001735 putative IPP diphosphate binding site; other site 712961001736 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 712961001737 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 712961001738 RIP metalloprotease RseP; Region: TIGR00054 712961001739 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 712961001740 active site 712961001741 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 712961001742 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 712961001743 protein binding site [polypeptide binding]; other site 712961001744 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 712961001745 putative substrate binding region [chemical binding]; other site 712961001746 prolyl-tRNA synthetase; Provisional; Region: PRK09194 712961001747 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 712961001748 dimer interface [polypeptide binding]; other site 712961001749 motif 1; other site 712961001750 active site 712961001751 motif 2; other site 712961001752 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 712961001753 putative deacylase active site [active] 712961001754 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 712961001755 active site 712961001756 motif 3; other site 712961001757 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 712961001758 anticodon binding site; other site 712961001759 DNA polymerase III PolC; Validated; Region: polC; PRK00448 712961001760 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 712961001761 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 712961001762 generic binding surface II; other site 712961001763 generic binding surface I; other site 712961001764 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 712961001765 active site 712961001766 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 712961001767 active site 712961001768 catalytic site [active] 712961001769 substrate binding site [chemical binding]; other site 712961001770 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 712961001771 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 712961001772 NusA N-terminal domain; Region: NusA_N; pfam08529 712961001773 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 712961001774 RNA binding site [nucleotide binding]; other site 712961001775 homodimer interface [polypeptide binding]; other site 712961001776 NusA-like KH domain; Region: KH_5; pfam13184 712961001777 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 712961001778 G-X-X-G motif; other site 712961001779 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 712961001780 translation initiation factor IF-2; Region: IF-2; TIGR00487 712961001781 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 712961001782 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 712961001783 G1 box; other site 712961001784 putative GEF interaction site [polypeptide binding]; other site 712961001785 GTP/Mg2+ binding site [chemical binding]; other site 712961001786 Switch I region; other site 712961001787 G2 box; other site 712961001788 G3 box; other site 712961001789 Switch II region; other site 712961001790 G4 box; other site 712961001791 G5 box; other site 712961001792 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 712961001793 Translation-initiation factor 2; Region: IF-2; pfam11987 712961001794 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 712961001795 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 712961001796 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 712961001797 RNA binding site [nucleotide binding]; other site 712961001798 active site 712961001799 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 712961001800 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 712961001801 active site 712961001802 Riboflavin kinase; Region: Flavokinase; pfam01687 712961001803 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 712961001804 GrpE; Region: GrpE; pfam01025 712961001805 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 712961001806 dimer interface [polypeptide binding]; other site 712961001807 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 712961001808 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 712961001809 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 712961001810 nucleotide binding site [chemical binding]; other site 712961001811 NEF interaction site [polypeptide binding]; other site 712961001812 SBD interface [polypeptide binding]; other site 712961001813 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 712961001814 chaperone protein DnaJ; Provisional; Region: PRK14276 712961001815 HSP70 interaction site [polypeptide binding]; other site 712961001816 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 712961001817 substrate binding site [polypeptide binding]; other site 712961001818 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 712961001819 Zn binding sites [ion binding]; other site 712961001820 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 712961001821 substrate binding site [polypeptide binding]; other site 712961001822 dimer interface [polypeptide binding]; other site 712961001823 GTP-binding protein LepA; Provisional; Region: PRK05433 712961001824 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 712961001825 G1 box; other site 712961001826 putative GEF interaction site [polypeptide binding]; other site 712961001827 GTP/Mg2+ binding site [chemical binding]; other site 712961001828 Switch I region; other site 712961001829 G2 box; other site 712961001830 G3 box; other site 712961001831 Switch II region; other site 712961001832 G4 box; other site 712961001833 G5 box; other site 712961001834 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 712961001835 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 712961001836 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 712961001837 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961001838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961001839 substrate binding pocket [chemical binding]; other site 712961001840 membrane-bound complex binding site; other site 712961001841 hinge residues; other site 712961001842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961001843 dimer interface [polypeptide binding]; other site 712961001844 conserved gate region; other site 712961001845 putative PBP binding loops; other site 712961001846 ABC-ATPase subunit interface; other site 712961001847 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712961001848 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 712961001849 Walker A/P-loop; other site 712961001850 ATP binding site [chemical binding]; other site 712961001851 Q-loop/lid; other site 712961001852 ABC transporter signature motif; other site 712961001853 Walker B; other site 712961001854 D-loop; other site 712961001855 H-loop/switch region; other site 712961001856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 712961001857 Beta-lactamase; Region: Beta-lactamase; pfam00144 712961001858 putative transposase OrfB; Reviewed; Region: PHA02517 712961001859 HTH-like domain; Region: HTH_21; pfam13276 712961001860 Integrase core domain; Region: rve; pfam00665 712961001861 Integrase core domain; Region: rve_2; pfam13333 712961001862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 712961001863 Helix-turn-helix domain; Region: HTH_28; pfam13518 712961001864 Transposase; Region: HTH_Tnp_1; cl17663 712961001865 Helix-turn-helix domain; Region: HTH_28; pfam13518 712961001866 Winged helix-turn helix; Region: HTH_29; pfam13551 712961001867 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 712961001868 catalytic triad [active] 712961001869 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 712961001870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961001871 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 712961001872 thymidine kinase; Provisional; Region: PRK04296 712961001873 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 712961001874 ATP binding site [chemical binding]; other site 712961001875 Walker A motif; other site 712961001876 Walker B motif; other site 712961001877 peptide chain release factor 1; Validated; Region: prfA; PRK00591 712961001878 This domain is found in peptide chain release factors; Region: PCRF; smart00937 712961001879 RF-1 domain; Region: RF-1; pfam00472 712961001880 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 712961001881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001882 S-adenosylmethionine binding site [chemical binding]; other site 712961001883 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 712961001884 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 712961001885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961001886 active site 712961001887 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 712961001888 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 712961001889 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 712961001890 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 712961001891 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 712961001892 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 712961001893 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 712961001894 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 712961001895 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 712961001896 beta subunit interaction interface [polypeptide binding]; other site 712961001897 Walker A motif; other site 712961001898 ATP binding site [chemical binding]; other site 712961001899 Walker B motif; other site 712961001900 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 712961001901 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 712961001902 core domain interface [polypeptide binding]; other site 712961001903 delta subunit interface [polypeptide binding]; other site 712961001904 epsilon subunit interface [polypeptide binding]; other site 712961001905 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 712961001906 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 712961001907 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 712961001908 alpha subunit interaction interface [polypeptide binding]; other site 712961001909 Walker A motif; other site 712961001910 ATP binding site [chemical binding]; other site 712961001911 Walker B motif; other site 712961001912 inhibitor binding site; inhibition site 712961001913 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 712961001914 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 712961001915 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 712961001916 hinge; other site 712961001917 active site 712961001918 rod shape-determining protein MreB; Provisional; Region: PRK13930 712961001919 MreB and similar proteins; Region: MreB_like; cd10225 712961001920 nucleotide binding site [chemical binding]; other site 712961001921 RodZ interaction site [polypeptide binding]; other site 712961001922 putative protofilament interaction site [polypeptide binding]; other site 712961001923 Mg binding site [ion binding]; other site 712961001924 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 712961001925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961001926 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961001927 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 712961001928 Phosphotransferase enzyme family; Region: APH; pfam01636 712961001929 active site 712961001930 ATP binding site [chemical binding]; other site 712961001931 substrate binding site [chemical binding]; other site 712961001932 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 712961001933 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 712961001934 catalytic site [active] 712961001935 G-X2-G-X-G-K; other site 712961001936 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 712961001937 Flavoprotein; Region: Flavoprotein; pfam02441 712961001938 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 712961001939 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 712961001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961001941 ATP binding site [chemical binding]; other site 712961001942 putative Mg++ binding site [ion binding]; other site 712961001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961001944 ATP-binding site [chemical binding]; other site 712961001945 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 712961001946 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 712961001947 putative active site [active] 712961001948 substrate binding site [chemical binding]; other site 712961001949 putative cosubstrate binding site; other site 712961001950 catalytic site [active] 712961001951 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 712961001952 substrate binding site [chemical binding]; other site 712961001953 16S rRNA methyltransferase B; Provisional; Region: PRK14902 712961001954 NusB family; Region: NusB; pfam01029 712961001955 putative RNA binding site [nucleotide binding]; other site 712961001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961001957 S-adenosylmethionine binding site [chemical binding]; other site 712961001958 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 712961001959 active site 712961001960 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 712961001961 Catalytic domain of Protein Kinases; Region: PKc; cd00180 712961001962 active site 712961001963 ATP binding site [chemical binding]; other site 712961001964 substrate binding site [chemical binding]; other site 712961001965 activation loop (A-loop); other site 712961001966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712961001967 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712961001968 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712961001969 GTPase RsgA; Reviewed; Region: PRK00098 712961001970 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 712961001971 RNA binding site [nucleotide binding]; other site 712961001972 homodimer interface [polypeptide binding]; other site 712961001973 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 712961001974 GTPase/Zn-binding domain interface [polypeptide binding]; other site 712961001975 GTP/Mg2+ binding site [chemical binding]; other site 712961001976 G4 box; other site 712961001977 G5 box; other site 712961001978 G1 box; other site 712961001979 Switch I region; other site 712961001980 G2 box; other site 712961001981 G3 box; other site 712961001982 Switch II region; other site 712961001983 Thiamine pyrophosphokinase; Region: TPK; cd07995 712961001984 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 712961001985 active site 712961001986 dimerization interface [polypeptide binding]; other site 712961001987 thiamine binding site [chemical binding]; other site 712961001988 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 712961001989 DAK2 domain; Region: Dak2; pfam02734 712961001990 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 712961001991 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 712961001992 generic binding surface II; other site 712961001993 ssDNA binding site; other site 712961001994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961001995 ATP binding site [chemical binding]; other site 712961001996 putative Mg++ binding site [ion binding]; other site 712961001997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961001998 nucleotide binding region [chemical binding]; other site 712961001999 ATP-binding site [chemical binding]; other site 712961002000 putative phosphate acyltransferase; Provisional; Region: PRK05331 712961002001 ribonuclease III; Reviewed; Region: rnc; PRK00102 712961002002 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 712961002003 dimerization interface [polypeptide binding]; other site 712961002004 active site 712961002005 metal binding site [ion binding]; metal-binding site 712961002006 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 712961002007 dsRNA binding site [nucleotide binding]; other site 712961002008 potential frameshift: common BLAST hit: gi|90961603|ref|YP_535519.1| chromosome partition protein 712961002009 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 712961002010 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 712961002011 Walker A/P-loop; other site 712961002012 ATP binding site [chemical binding]; other site 712961002013 Q-loop/lid; other site 712961002014 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 712961002015 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 712961002016 Q-loop/lid; other site 712961002017 ABC transporter signature motif; other site 712961002018 Walker B; other site 712961002019 D-loop; other site 712961002020 H-loop/switch region; other site 712961002021 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 712961002022 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 712961002023 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 712961002024 P loop; other site 712961002025 GTP binding site [chemical binding]; other site 712961002026 signal recognition particle protein; Provisional; Region: PRK10867 712961002027 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 712961002028 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 712961002029 P loop; other site 712961002030 GTP binding site [chemical binding]; other site 712961002031 Signal peptide binding domain; Region: SRP_SPB; pfam02978 712961002032 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 712961002033 RimM N-terminal domain; Region: RimM; pfam01782 712961002034 PRC-barrel domain; Region: PRC; pfam05239 712961002035 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 712961002036 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 712961002037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961002038 Coenzyme A binding pocket [chemical binding]; other site 712961002039 amino acid transporter; Region: 2A0306; TIGR00909 712961002040 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712961002041 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 712961002042 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 712961002043 dimer interface [polypeptide binding]; other site 712961002044 active site 712961002045 catalytic residue [active] 712961002046 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 712961002047 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 712961002048 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 712961002049 elongation factor Tu; Reviewed; Region: PRK00049 712961002050 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 712961002051 G1 box; other site 712961002052 GEF interaction site [polypeptide binding]; other site 712961002053 GTP/Mg2+ binding site [chemical binding]; other site 712961002054 Switch I region; other site 712961002055 G2 box; other site 712961002056 G3 box; other site 712961002057 Switch II region; other site 712961002058 G4 box; other site 712961002059 G5 box; other site 712961002060 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 712961002061 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 712961002062 Antibiotic Binding Site [chemical binding]; other site 712961002063 trigger factor; Provisional; Region: tig; PRK01490 712961002064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 712961002065 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 712961002066 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 712961002067 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 712961002068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961002069 Walker A motif; other site 712961002070 ATP binding site [chemical binding]; other site 712961002071 Walker B motif; other site 712961002072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 712961002073 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 712961002074 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 712961002075 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 712961002076 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 712961002077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 712961002078 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 712961002079 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 712961002080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 712961002081 active site 712961002082 catalytic residues [active] 712961002083 metal binding site [ion binding]; metal-binding site 712961002084 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 712961002085 substrate binding site [chemical binding]; other site 712961002086 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 712961002087 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 712961002088 active site 712961002089 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 712961002090 G4 box; other site 712961002091 G5 box; other site 712961002092 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 712961002093 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 712961002094 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 712961002095 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 712961002096 active pocket/dimerization site; other site 712961002097 active site 712961002098 phosphorylation site [posttranslational modification] 712961002099 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 712961002100 active site 712961002101 phosphorylation site [posttranslational modification] 712961002102 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 712961002103 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 712961002104 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 712961002105 pyruvate carboxylase; Reviewed; Region: PRK12999 712961002106 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712961002107 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712961002108 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 712961002109 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 712961002110 active site 712961002111 catalytic residues [active] 712961002112 metal binding site [ion binding]; metal-binding site 712961002113 homodimer binding site [polypeptide binding]; other site 712961002114 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 712961002115 carboxyltransferase (CT) interaction site; other site 712961002116 biotinylation site [posttranslational modification]; other site 712961002117 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 712961002118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 712961002119 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 712961002120 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 712961002121 active site 712961002122 (T/H)XGH motif; other site 712961002123 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 712961002124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 712961002125 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 712961002126 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 712961002127 ATP binding site [chemical binding]; other site 712961002128 active site 712961002129 substrate binding site [chemical binding]; other site 712961002130 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 712961002131 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 712961002132 dimerization interface [polypeptide binding]; other site 712961002133 ATP binding site [chemical binding]; other site 712961002134 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 712961002135 dimerization interface [polypeptide binding]; other site 712961002136 ATP binding site [chemical binding]; other site 712961002137 amidophosphoribosyltransferase; Provisional; Region: PRK07272 712961002138 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 712961002139 active site 712961002140 tetramer interface [polypeptide binding]; other site 712961002141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961002142 active site 712961002143 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 712961002144 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 712961002145 dimerization interface [polypeptide binding]; other site 712961002146 putative ATP binding site [chemical binding]; other site 712961002147 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 712961002148 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 712961002149 active site 712961002150 substrate binding site [chemical binding]; other site 712961002151 cosubstrate binding site; other site 712961002152 catalytic site [active] 712961002153 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 712961002154 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 712961002155 purine monophosphate binding site [chemical binding]; other site 712961002156 dimer interface [polypeptide binding]; other site 712961002157 putative catalytic residues [active] 712961002158 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 712961002159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 712961002160 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 712961002161 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 712961002162 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 712961002163 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 712961002164 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 712961002165 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 712961002166 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 712961002167 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 712961002168 putative active site [active] 712961002169 catalytic site [active] 712961002170 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 712961002171 putative active site [active] 712961002172 catalytic site [active] 712961002173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961002174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961002175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 712961002176 dimerization interface [polypeptide binding]; other site 712961002177 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 712961002178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961002179 active site 712961002180 motif I; other site 712961002181 motif II; other site 712961002182 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 712961002183 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 712961002184 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 712961002185 active site 712961002186 HIGH motif; other site 712961002187 KMSK motif region; other site 712961002188 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 712961002189 tRNA binding surface [nucleotide binding]; other site 712961002190 anticodon binding site; other site 712961002191 SLBB domain; Region: SLBB; pfam10531 712961002192 comEA protein; Region: comE; TIGR01259 712961002193 Helix-hairpin-helix motif; Region: HHH; pfam00633 712961002194 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 712961002195 catalytic motif [active] 712961002196 Zn binding site [ion binding]; other site 712961002197 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 712961002198 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 712961002199 Competence protein; Region: Competence; pfam03772 712961002200 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 712961002201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 712961002202 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 712961002203 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 712961002204 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 712961002205 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 712961002206 homotetramer interface [polypeptide binding]; other site 712961002207 FMN binding site [chemical binding]; other site 712961002208 homodimer contacts [polypeptide binding]; other site 712961002209 putative active site [active] 712961002210 putative substrate binding site [chemical binding]; other site 712961002211 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 712961002212 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712961002213 diphosphomevalonate decarboxylase; Region: PLN02407 712961002214 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 712961002215 mevalonate kinase; Region: mevalon_kin; TIGR00549 712961002216 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712961002217 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 712961002218 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 712961002219 active site 712961002220 catalytic site [active] 712961002221 substrate binding site [chemical binding]; other site 712961002222 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 712961002223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 712961002224 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 712961002225 aspartate aminotransferase; Provisional; Region: PRK05764 712961002226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961002227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961002228 homodimer interface [polypeptide binding]; other site 712961002229 catalytic residue [active] 712961002230 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 712961002231 Dimer interface [polypeptide binding]; other site 712961002232 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 712961002233 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 712961002234 homodimer interface [polypeptide binding]; other site 712961002235 motif 1; other site 712961002236 motif 2; other site 712961002237 active site 712961002238 motif 3; other site 712961002239 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 712961002240 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 712961002241 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 712961002242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 712961002243 minor groove reading motif; other site 712961002244 helix-hairpin-helix signature motif; other site 712961002245 substrate binding pocket [chemical binding]; other site 712961002246 active site 712961002247 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 712961002248 methionine sulfoxide reductase A; Provisional; Region: PRK14054 712961002249 Uncharacterized conserved protein [Function unknown]; Region: COG1284 712961002250 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961002251 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961002252 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 712961002253 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 712961002254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961002255 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 712961002256 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 712961002257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712961002258 active site 712961002259 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 712961002260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712961002261 Uncharacterized conserved protein [Function unknown]; Region: COG1284 712961002262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961002263 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961002264 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 712961002265 dihydrodipicolinate reductase; Provisional; Region: PRK00048 712961002266 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 712961002267 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 712961002268 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 712961002269 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 712961002270 active site 712961002271 NTP binding site [chemical binding]; other site 712961002272 metal binding triad [ion binding]; metal-binding site 712961002273 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 712961002274 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 712961002275 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712961002276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961002277 Walker A/P-loop; other site 712961002278 ATP binding site [chemical binding]; other site 712961002279 Q-loop/lid; other site 712961002280 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961002281 ABC transporter signature motif; other site 712961002282 Walker B; other site 712961002283 D-loop; other site 712961002284 ABC transporter; Region: ABC_tran_2; pfam12848 712961002285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961002286 thymidylate synthase; Region: thym_sym; TIGR03284 712961002287 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 712961002288 dimerization interface [polypeptide binding]; other site 712961002289 active site 712961002290 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 712961002291 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 712961002292 folate binding site [chemical binding]; other site 712961002293 NADP+ binding site [chemical binding]; other site 712961002294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961002295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961002296 active site 712961002297 catalytic tetrad [active] 712961002298 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 712961002299 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 712961002300 DNA binding residues [nucleotide binding] 712961002301 putative dimer interface [polypeptide binding]; other site 712961002302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961002303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961002304 active site 712961002305 catalytic tetrad [active] 712961002306 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 712961002307 active site 712961002308 catalytic triad [active] 712961002309 oxyanion hole [active] 712961002310 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 712961002311 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 712961002312 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 712961002313 GTP/Mg2+ binding site [chemical binding]; other site 712961002314 G4 box; other site 712961002315 G5 box; other site 712961002316 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 712961002317 G1 box; other site 712961002318 G1 box; other site 712961002319 GTP/Mg2+ binding site [chemical binding]; other site 712961002320 Switch I region; other site 712961002321 G2 box; other site 712961002322 G2 box; other site 712961002323 G3 box; other site 712961002324 G3 box; other site 712961002325 Switch II region; other site 712961002326 Switch II region; other site 712961002327 G4 box; other site 712961002328 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 712961002329 RNA/DNA hybrid binding site [nucleotide binding]; other site 712961002330 active site 712961002331 DNA protecting protein DprA; Region: dprA; TIGR00732 712961002332 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 712961002333 potential frameshift: common BLAST hit: gi|90961697|ref|YP_535613.1| DNA topoisomerase I 712961002334 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 712961002335 active site 712961002336 interdomain interaction site; other site 712961002337 putative metal-binding site [ion binding]; other site 712961002338 nucleotide binding site [chemical binding]; other site 712961002339 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 712961002340 domain I; other site 712961002341 phosphate binding site [ion binding]; other site 712961002342 DNA topoisomerase I; Validated; Region: PRK05582 712961002343 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 712961002344 domain III; other site 712961002345 DNA binding groove [nucleotide binding] 712961002346 catalytic site [active] 712961002347 nucleotide binding site [chemical binding]; other site 712961002348 domain II; other site 712961002349 domain IV; other site 712961002350 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712961002351 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712961002352 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712961002353 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 712961002354 Glucose inhibited division protein A; Region: GIDA; pfam01134 712961002355 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 712961002356 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 712961002357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961002358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961002359 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712961002360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 712961002361 Walker A/P-loop; other site 712961002362 ATP binding site [chemical binding]; other site 712961002363 Q-loop/lid; other site 712961002364 ABC transporter signature motif; other site 712961002365 Walker B; other site 712961002366 D-loop; other site 712961002367 H-loop/switch region; other site 712961002368 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 712961002369 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 712961002370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961002371 catalytic core [active] 712961002372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712961002373 TPR motif; other site 712961002374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 712961002375 binding surface 712961002376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 712961002377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712961002378 TPR motif; other site 712961002379 binding surface 712961002380 potential frameshift: common BLAST hit: gi|90961705|ref|YP_535621.1| exodeoxyribonuclease V alpha chain 712961002381 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 712961002382 AAA domain; Region: AAA_30; pfam13604 712961002383 Family description; Region: UvrD_C_2; pfam13538 712961002384 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 712961002385 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961002386 Int/Topo IB signature motif; other site 712961002387 Probable transposase; Region: OrfB_IS605; pfam01385 712961002388 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712961002389 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 712961002390 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 712961002391 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 712961002392 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 712961002393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712961002394 ATP binding site [chemical binding]; other site 712961002395 putative Mg++ binding site [ion binding]; other site 712961002396 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 712961002397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961002398 nucleotide binding region [chemical binding]; other site 712961002399 ATP-binding site [chemical binding]; other site 712961002400 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 712961002401 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 712961002402 AAA domain; Region: AAA_24; pfam13479 712961002403 DNA polymerase type-B family; Region: POLBc; smart00486 712961002404 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 712961002405 active site 712961002406 metal-binding site 712961002407 D5 N terminal like; Region: D5_N; smart00885 712961002408 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 712961002409 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 712961002410 HNH endonuclease; Region: HNH_3; pfam13392 712961002411 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961002412 Int/Topo IB signature motif; other site 712961002413 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 712961002414 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 712961002415 Phage-related protein [Function unknown]; Region: COG4695 712961002416 Phage portal protein; Region: Phage_portal; pfam04860 712961002417 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 712961002418 oligomer interface [polypeptide binding]; other site 712961002419 Clp protease; Region: CLP_protease; pfam00574 712961002420 active site residues [active] 712961002421 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 712961002422 Phage capsid family; Region: Phage_capsid; pfam05065 712961002423 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 712961002424 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 712961002425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 712961002426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 712961002427 catalytic residue [active] 712961002428 Phage tail protein; Region: Sipho_tail; pfam05709 712961002429 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712961002430 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712961002431 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 712961002432 Peptidase family M23; Region: Peptidase_M23; pfam01551 712961002433 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712961002434 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 712961002435 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 712961002436 active site 712961002437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961002438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961002439 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 712961002440 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 712961002441 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 712961002442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961002443 Zn2+ binding site [ion binding]; other site 712961002444 Mg2+ binding site [ion binding]; other site 712961002445 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 712961002446 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 712961002447 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 712961002448 dimer interface [polypeptide binding]; other site 712961002449 motif 1; other site 712961002450 active site 712961002451 motif 2; other site 712961002452 motif 3; other site 712961002453 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 712961002454 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 712961002455 putative tRNA-binding site [nucleotide binding]; other site 712961002456 B3/4 domain; Region: B3_4; pfam03483 712961002457 tRNA synthetase B5 domain; Region: B5; smart00874 712961002458 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 712961002459 dimer interface [polypeptide binding]; other site 712961002460 motif 1; other site 712961002461 motif 3; other site 712961002462 motif 2; other site 712961002463 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 712961002464 YceG-like family; Region: YceG; pfam02618 712961002465 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 712961002466 dimerization interface [polypeptide binding]; other site 712961002467 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 712961002468 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 712961002469 Sugar specificity; other site 712961002470 Pyrimidine base specificity; other site 712961002471 ATP-binding site [chemical binding]; other site 712961002472 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 712961002473 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 712961002474 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 712961002475 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 712961002476 active site 712961002477 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 712961002478 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 712961002479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961002480 S-adenosylmethionine binding site [chemical binding]; other site 712961002481 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 712961002482 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 712961002483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961002484 Zn2+ binding site [ion binding]; other site 712961002485 Mg2+ binding site [ion binding]; other site 712961002486 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 712961002487 synthetase active site [active] 712961002488 NTP binding site [chemical binding]; other site 712961002489 metal binding site [ion binding]; metal-binding site 712961002490 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 712961002491 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 712961002492 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 712961002493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961002494 motif II; other site 712961002495 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712961002496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961002497 RNA binding surface [nucleotide binding]; other site 712961002498 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712961002499 active site 712961002500 uracil transporter; Provisional; Region: PRK10720 712961002501 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 712961002502 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 712961002503 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 712961002504 catalytic site [active] 712961002505 subunit interface [polypeptide binding]; other site 712961002506 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 712961002507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712961002508 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 712961002509 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 712961002510 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 712961002511 active site 712961002512 dimer interface [polypeptide binding]; other site 712961002513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961002514 active site 712961002515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961002516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961002517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 712961002518 dimerization interface [polypeptide binding]; other site 712961002519 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 712961002520 DHH family; Region: DHH; pfam01368 712961002521 DHHA2 domain; Region: DHHA2; pfam02833 712961002522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 712961002523 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 712961002524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 712961002525 aromatic amino acid aminotransferase; Validated; Region: PRK07309 712961002526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961002527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961002528 homodimer interface [polypeptide binding]; other site 712961002529 catalytic residue [active] 712961002530 glutamate racemase; Provisional; Region: PRK00865 712961002531 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 712961002532 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 712961002533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 712961002534 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 712961002535 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 712961002536 Potassium binding sites [ion binding]; other site 712961002537 Cesium cation binding sites [ion binding]; other site 712961002538 potential frameshift: common BLAST hit: gi|295693875|ref|YP_003602485.1| major facilitator superfamily permease 712961002539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961002540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961002541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961002542 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 712961002543 Family of unknown function (DUF633); Region: DUF633; pfam04816 712961002544 Uncharacterized conserved protein [Function unknown]; Region: COG0327 712961002545 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 712961002546 peptidase T; Region: peptidase-T; TIGR01882 712961002547 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 712961002548 metal binding site [ion binding]; metal-binding site 712961002549 dimer interface [polypeptide binding]; other site 712961002550 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 712961002551 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 712961002552 active site 712961002553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 712961002554 EamA-like transporter family; Region: EamA; pfam00892 712961002555 EamA-like transporter family; Region: EamA; pfam00892 712961002556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 712961002557 TPR motif; other site 712961002558 binding surface 712961002559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712961002560 binding surface 712961002561 TPR motif; other site 712961002562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712961002563 TPR motif; other site 712961002564 binding surface 712961002565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 712961002566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712961002567 binding surface 712961002568 TPR motif; other site 712961002569 histidyl-tRNA synthetase; Region: hisS; TIGR00442 712961002570 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 712961002571 dimer interface [polypeptide binding]; other site 712961002572 motif 1; other site 712961002573 active site 712961002574 motif 2; other site 712961002575 motif 3; other site 712961002576 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 712961002577 anticodon binding site; other site 712961002578 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 712961002579 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 712961002580 dimer interface [polypeptide binding]; other site 712961002581 anticodon binding site; other site 712961002582 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 712961002583 homodimer interface [polypeptide binding]; other site 712961002584 motif 1; other site 712961002585 active site 712961002586 motif 2; other site 712961002587 GAD domain; Region: GAD; pfam02938 712961002588 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 712961002589 motif 3; other site 712961002590 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 712961002591 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 712961002592 oligomer interface [polypeptide binding]; other site 712961002593 Cl binding site [ion binding]; other site 712961002594 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 712961002595 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 712961002596 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 712961002597 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 712961002598 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 712961002599 dimer interface [polypeptide binding]; other site 712961002600 ADP-ribose binding site [chemical binding]; other site 712961002601 active site 712961002602 nudix motif; other site 712961002603 metal binding site [ion binding]; metal-binding site 712961002604 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 712961002605 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 712961002606 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 712961002607 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 712961002608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712961002609 catalytic residue [active] 712961002610 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 712961002611 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 712961002612 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 712961002613 Clp amino terminal domain; Region: Clp_N; pfam02861 712961002614 Clp amino terminal domain; Region: Clp_N; pfam02861 712961002615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961002616 Walker A motif; other site 712961002617 ATP binding site [chemical binding]; other site 712961002618 Walker B motif; other site 712961002619 arginine finger; other site 712961002620 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 712961002621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961002622 Walker A motif; other site 712961002623 ATP binding site [chemical binding]; other site 712961002624 Walker B motif; other site 712961002625 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 712961002626 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 712961002627 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 712961002628 active site 712961002629 PHP Thumb interface [polypeptide binding]; other site 712961002630 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 712961002631 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 712961002632 generic binding surface I; other site 712961002633 generic binding surface II; other site 712961002634 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 712961002635 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 712961002636 active site 712961002637 ADP/pyrophosphate binding site [chemical binding]; other site 712961002638 dimerization interface [polypeptide binding]; other site 712961002639 allosteric effector site; other site 712961002640 fructose-1,6-bisphosphate binding site; other site 712961002641 pyruvate kinase; Provisional; Region: PRK06354 712961002642 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 712961002643 domain interfaces; other site 712961002644 active site 712961002645 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 712961002646 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 712961002647 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 712961002648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961002649 ATP binding site [chemical binding]; other site 712961002650 Mg2+ binding site [ion binding]; other site 712961002651 G-X-G motif; other site 712961002652 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 712961002653 anchoring element; other site 712961002654 dimer interface [polypeptide binding]; other site 712961002655 ATP binding site [chemical binding]; other site 712961002656 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 712961002657 active site 712961002658 putative metal-binding site [ion binding]; other site 712961002659 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 712961002660 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 712961002661 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 712961002662 CAP-like domain; other site 712961002663 active site 712961002664 primary dimer interface [polypeptide binding]; other site 712961002665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712961002666 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 712961002667 Domain of unknown function (DUF814); Region: DUF814; pfam05670 712961002668 EDD domain protein, DegV family; Region: DegV; TIGR00762 712961002669 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712961002670 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 712961002671 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 712961002672 Catalytic site [active] 712961002673 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 712961002674 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 712961002675 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 712961002676 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 712961002677 dimer interface [polypeptide binding]; other site 712961002678 active site 712961002679 glycine-pyridoxal phosphate binding site [chemical binding]; other site 712961002680 folate binding site [chemical binding]; other site 712961002681 putative phosphoesterase; Region: acc_ester; TIGR03729 712961002682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712961002683 EamA-like transporter family; Region: EamA; pfam00892 712961002684 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 712961002685 EamA-like transporter family; Region: EamA; pfam00892 712961002686 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 712961002687 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 712961002688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961002689 Walker A/P-loop; other site 712961002690 ATP binding site [chemical binding]; other site 712961002691 Q-loop/lid; other site 712961002692 ABC transporter signature motif; other site 712961002693 Walker B; other site 712961002694 D-loop; other site 712961002695 H-loop/switch region; other site 712961002696 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 712961002697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961002698 Coenzyme A binding pocket [chemical binding]; other site 712961002699 GTP-binding protein Der; Reviewed; Region: PRK00093 712961002700 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 712961002701 G1 box; other site 712961002702 GTP/Mg2+ binding site [chemical binding]; other site 712961002703 Switch I region; other site 712961002704 G2 box; other site 712961002705 Switch II region; other site 712961002706 G3 box; other site 712961002707 G4 box; other site 712961002708 G5 box; other site 712961002709 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 712961002710 G1 box; other site 712961002711 GTP/Mg2+ binding site [chemical binding]; other site 712961002712 Switch I region; other site 712961002713 G2 box; other site 712961002714 G3 box; other site 712961002715 Switch II region; other site 712961002716 G4 box; other site 712961002717 G5 box; other site 712961002718 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 712961002719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 712961002720 RNA binding site [nucleotide binding]; other site 712961002721 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 712961002722 RNA binding site [nucleotide binding]; other site 712961002723 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 712961002724 RNA binding site [nucleotide binding]; other site 712961002725 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 712961002726 RNA binding site [nucleotide binding]; other site 712961002727 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 712961002728 DltD N-terminal region; Region: DltD_N; pfam04915 712961002729 DltD central region; Region: DltD_M; pfam04918 712961002730 DltD C-terminal region; Region: DltD_C; pfam04914 712961002731 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 712961002732 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 712961002733 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 712961002734 acyl-activating enzyme (AAE) consensus motif; other site 712961002735 AMP binding site [chemical binding]; other site 712961002736 Recombination protein O N terminal; Region: RecO_N; pfam11967 712961002737 DNA repair protein RecO; Region: reco; TIGR00613 712961002738 Recombination protein O C terminal; Region: RecO_C; pfam02565 712961002739 GTPase Era; Reviewed; Region: era; PRK00089 712961002740 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 712961002741 G1 box; other site 712961002742 GTP/Mg2+ binding site [chemical binding]; other site 712961002743 Switch I region; other site 712961002744 G2 box; other site 712961002745 Switch II region; other site 712961002746 G3 box; other site 712961002747 G4 box; other site 712961002748 G5 box; other site 712961002749 KH domain; Region: KH_2; pfam07650 712961002750 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 712961002751 PhoH-like protein; Region: PhoH; pfam02562 712961002752 Bacterial SH3 domain homologues; Region: SH3b; smart00287 712961002753 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 712961002754 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 712961002755 active site 712961002756 metal binding site [ion binding]; metal-binding site 712961002757 cytidylate kinase; Provisional; Region: cmk; PRK00023 712961002758 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 712961002759 CMP-binding site; other site 712961002760 The sites determining sugar specificity; other site 712961002761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961002762 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 712961002763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961002764 ATP binding site [chemical binding]; other site 712961002765 putative Mg++ binding site [ion binding]; other site 712961002766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961002767 nucleotide binding region [chemical binding]; other site 712961002768 ATP-binding site [chemical binding]; other site 712961002769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 712961002770 manganese transport protein MntH; Reviewed; Region: PRK00701 712961002771 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 712961002772 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 712961002773 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 712961002774 DXD motif; other site 712961002775 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 712961002776 conserved hypothetical integral membrane protein; Region: TIGR03766 712961002777 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 712961002778 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 712961002779 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 712961002780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 712961002781 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 712961002782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 712961002783 DNA binding residues [nucleotide binding] 712961002784 potential frameshift: common BLAST hit: gi|90961887|ref|YP_535803.1| DNA primase 712961002785 DNA primase; Validated; Region: dnaG; PRK05667 712961002786 CHC2 zinc finger; Region: zf-CHC2; pfam01807 712961002787 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 712961002788 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 712961002789 active site 712961002790 metal binding site [ion binding]; metal-binding site 712961002791 interdomain interaction site; other site 712961002792 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 712961002793 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 712961002794 dimer interface [polypeptide binding]; other site 712961002795 motif 1; other site 712961002796 active site 712961002797 motif 2; other site 712961002798 motif 3; other site 712961002799 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 712961002800 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 712961002801 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 712961002802 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961002803 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961002804 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961002805 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 712961002806 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 712961002807 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961002808 Int/Topo IB signature motif; other site 712961002809 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961002810 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 712961002811 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961002812 HsdM N-terminal domain; Region: HsdM_N; pfam12161 712961002813 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 712961002814 Methyltransferase domain; Region: Methyltransf_26; pfam13659 712961002815 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 712961002816 potential frameshift: common BLAST hit: gi|90961897|ref|YP_535813.1| type I restriction-modification system restriction subunit 712961002817 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 712961002818 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 712961002819 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712961002820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961002821 ATP binding site [chemical binding]; other site 712961002822 putative Mg++ binding site [ion binding]; other site 712961002823 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 712961002824 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 712961002825 active site 712961002826 maltose O-acetyltransferase; Provisional; Region: PRK10092 712961002827 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 712961002828 active site 712961002829 substrate binding site [chemical binding]; other site 712961002830 trimer interface [polypeptide binding]; other site 712961002831 CoA binding site [chemical binding]; other site 712961002832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 712961002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961002834 Coenzyme A binding pocket [chemical binding]; other site 712961002835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961002836 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961002837 potential frameshift: common BLAST hit: gi|90961906|ref|YP_535822.1| adenine deaminase 712961002838 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 712961002839 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 712961002840 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 712961002841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 712961002842 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 712961002843 active site 712961002844 hypothetical protein; Provisional; Region: PRK13660 712961002845 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 712961002846 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 712961002847 Transglycosylase; Region: Transgly; pfam00912 712961002848 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 712961002849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 712961002850 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 712961002851 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 712961002852 active site 712961002853 Int/Topo IB signature motif; other site 712961002854 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 712961002855 S1 domain; Region: S1_2; pfam13509 712961002856 Predicted membrane protein [Function unknown]; Region: COG3601 712961002857 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 712961002858 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 712961002859 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961002860 RNA binding surface [nucleotide binding]; other site 712961002861 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 712961002862 active site 712961002863 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 712961002864 ScpA/B protein; Region: ScpA_ScpB; cl00598 712961002865 Protein of unknown function (DUF805); Region: DUF805; pfam05656 712961002866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 712961002867 Walker B motif; other site 712961002868 arginine finger; other site 712961002869 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 712961002870 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 712961002871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961002872 Walker A motif; other site 712961002873 ATP binding site [chemical binding]; other site 712961002874 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 712961002875 active site 712961002876 HslU subunit interaction site [polypeptide binding]; other site 712961002877 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712961002878 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 712961002879 active site 712961002880 DNA binding site [nucleotide binding] 712961002881 Int/Topo IB signature motif; other site 712961002882 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 712961002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961002884 S-adenosylmethionine binding site [chemical binding]; other site 712961002885 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 712961002886 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 712961002887 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 712961002888 nudix motif; other site 712961002889 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 712961002890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961002891 NAD(P) binding site [chemical binding]; other site 712961002892 active site 712961002893 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 712961002894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961002895 Coenzyme A binding pocket [chemical binding]; other site 712961002896 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 712961002897 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 712961002898 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 712961002899 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 712961002900 putative NAD(P) binding site [chemical binding]; other site 712961002901 Predicted transcriptional regulator [Transcription]; Region: COG1959 712961002902 Transcriptional regulator; Region: Rrf2; pfam02082 712961002903 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 712961002904 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 712961002905 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 712961002906 NADP binding site [chemical binding]; other site 712961002907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002908 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 712961002909 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961002910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961002912 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 712961002913 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 712961002914 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 712961002915 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 712961002916 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 712961002917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961002918 NAD(P) binding site [chemical binding]; other site 712961002919 active site 712961002920 potential frameshift: common BLAST hit: gi|90961956|ref|YP_535872.1| oligosaccharide translocase 712961002921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002922 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 712961002923 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 712961002924 putative ligand binding site [chemical binding]; other site 712961002925 putative catalytic site [active] 712961002926 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 712961002927 putative ligand binding site [chemical binding]; other site 712961002928 putative catalytic site [active] 712961002929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 712961002930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712961002931 active site 712961002932 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 712961002933 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 712961002934 Ligand binding site; other site 712961002935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002936 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 712961002937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002938 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 712961002939 putative ADP-binding pocket [chemical binding]; other site 712961002940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002941 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 712961002942 putative ADP-binding pocket [chemical binding]; other site 712961002943 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 712961002944 putative ADP-binding pocket [chemical binding]; other site 712961002945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961002946 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 712961002947 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 712961002948 putative trimer interface [polypeptide binding]; other site 712961002949 putative CoA binding site [chemical binding]; other site 712961002950 Bacterial sugar transferase; Region: Bac_transf; pfam02397 712961002951 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 712961002952 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 712961002953 inhibitor-cofactor binding pocket; inhibition site 712961002954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961002955 catalytic residue [active] 712961002956 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 712961002957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961002958 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 712961002959 NAD(P) binding site [chemical binding]; other site 712961002960 homodimer interface [polypeptide binding]; other site 712961002961 substrate binding site [chemical binding]; other site 712961002962 active site 712961002963 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 712961002964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 712961002965 Chain length determinant protein; Region: Wzz; cl15801 712961002966 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 712961002967 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 712961002968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961002969 Coenzyme A binding pocket [chemical binding]; other site 712961002970 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 712961002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961002972 S-adenosylmethionine binding site [chemical binding]; other site 712961002973 Uncharacterized conserved protein [Function unknown]; Region: COG3270 712961002974 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 712961002975 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712961002976 esterase; Provisional; Region: PRK10566 712961002977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961002978 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712961002979 active site 712961002980 motif I; other site 712961002981 motif II; other site 712961002982 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 712961002983 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 712961002984 Coenzyme A binding pocket [chemical binding]; other site 712961002985 diaminopimelate decarboxylase; Region: lysA; TIGR01048 712961002986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 712961002987 active site 712961002988 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 712961002989 substrate binding site [chemical binding]; other site 712961002990 catalytic residues [active] 712961002991 dimer interface [polypeptide binding]; other site 712961002992 Peptidase family C69; Region: Peptidase_C69; pfam03577 712961002993 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 712961002994 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 712961002995 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 712961002996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 712961002997 Predicted membrane protein [Function unknown]; Region: COG2364 712961002998 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 712961002999 Melibiase; Region: Melibiase; pfam02065 712961003000 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 712961003001 PLD-like domain; Region: PLDc_2; pfam13091 712961003002 putative homodimer interface [polypeptide binding]; other site 712961003003 putative active site [active] 712961003004 catalytic site [active] 712961003005 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 712961003006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961003007 ATP binding site [chemical binding]; other site 712961003008 putative Mg++ binding site [ion binding]; other site 712961003009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003010 nucleotide binding region [chemical binding]; other site 712961003011 ATP-binding site [chemical binding]; other site 712961003012 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 712961003013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961003014 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961003015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 712961003016 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 712961003017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 712961003018 metal binding site [ion binding]; metal-binding site 712961003019 active site 712961003020 I-site; other site 712961003021 potential frameshift: common BLAST hit: gi|90961993|ref|YP_535909.1| cellulose synthase catalytic subunit 712961003022 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 712961003023 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 712961003024 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 712961003025 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 712961003026 DXD motif; other site 712961003027 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 712961003028 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 712961003029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 712961003030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 712961003031 metal binding site [ion binding]; metal-binding site 712961003032 active site 712961003033 I-site; other site 712961003034 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 712961003035 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 712961003036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961003037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961003038 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 712961003039 UbiA prenyltransferase family; Region: UbiA; pfam01040 712961003040 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 712961003041 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 712961003042 substrate binding pocket [chemical binding]; other site 712961003043 chain length determination region; other site 712961003044 substrate-Mg2+ binding site; other site 712961003045 catalytic residues [active] 712961003046 aspartate-rich region 1; other site 712961003047 active site lid residues [active] 712961003048 aspartate-rich region 2; other site 712961003049 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 712961003050 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 712961003051 Walker A/P-loop; other site 712961003052 ATP binding site [chemical binding]; other site 712961003053 Q-loop/lid; other site 712961003054 ABC transporter signature motif; other site 712961003055 Walker B; other site 712961003056 D-loop; other site 712961003057 H-loop/switch region; other site 712961003058 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 712961003059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961003060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 712961003061 Walker A/P-loop; other site 712961003062 ATP binding site [chemical binding]; other site 712961003063 Q-loop/lid; other site 712961003064 ABC transporter signature motif; other site 712961003065 Walker B; other site 712961003066 D-loop; other site 712961003067 H-loop/switch region; other site 712961003068 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 712961003069 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 712961003070 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 712961003071 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 712961003072 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 712961003073 dimer interface [polypeptide binding]; other site 712961003074 active site 712961003075 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 712961003076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961003077 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 712961003078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712961003079 active site 712961003080 metal binding site [ion binding]; metal-binding site 712961003081 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 712961003082 nucleotide binding site/active site [active] 712961003083 HIT family signature motif; other site 712961003084 catalytic residue [active] 712961003085 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 712961003086 Uncharacterized conserved protein [Function unknown]; Region: COG1284 712961003087 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961003088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712961003089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 712961003090 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 712961003091 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 712961003092 active site 712961003093 HIGH motif; other site 712961003094 nucleotide binding site [chemical binding]; other site 712961003095 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 712961003096 active site 712961003097 KMSKS motif; other site 712961003098 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 712961003099 tRNA binding surface [nucleotide binding]; other site 712961003100 anticodon binding site; other site 712961003101 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 712961003102 DivIVA protein; Region: DivIVA; pfam05103 712961003103 DivIVA domain; Region: DivI1A_domain; TIGR03544 712961003104 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 712961003105 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 712961003106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961003107 RNA binding surface [nucleotide binding]; other site 712961003108 cell division protein FtsZ; Validated; Region: PRK09330 712961003109 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 712961003110 nucleotide binding site [chemical binding]; other site 712961003111 SulA interaction site; other site 712961003112 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 712961003113 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712961003114 nucleotide binding site [chemical binding]; other site 712961003115 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 712961003116 Cell division protein FtsA; Region: FtsA; pfam14450 712961003117 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 712961003118 Cell division protein FtsQ; Region: FtsQ; pfam03799 712961003119 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 712961003120 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 712961003121 active site 712961003122 homodimer interface [polypeptide binding]; other site 712961003123 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 712961003124 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 712961003125 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961003126 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712961003127 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 712961003128 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 712961003129 Mg++ binding site [ion binding]; other site 712961003130 putative catalytic motif [active] 712961003131 putative substrate binding site [chemical binding]; other site 712961003132 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 712961003133 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 712961003134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 712961003135 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 712961003136 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 712961003137 MraW methylase family; Region: Methyltransf_5; pfam01795 712961003138 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 712961003139 aspartate kinase I; Reviewed; Region: PRK08210 712961003140 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 712961003141 nucleotide binding site [chemical binding]; other site 712961003142 substrate binding site [chemical binding]; other site 712961003143 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 712961003144 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 712961003145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 712961003146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 712961003147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961003148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961003149 substrate binding pocket [chemical binding]; other site 712961003150 membrane-bound complex binding site; other site 712961003151 hinge residues; other site 712961003152 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961003153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961003154 Walker A/P-loop; other site 712961003155 ATP binding site [chemical binding]; other site 712961003156 Q-loop/lid; other site 712961003157 ABC transporter signature motif; other site 712961003158 Walker B; other site 712961003159 D-loop; other site 712961003160 H-loop/switch region; other site 712961003161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961003162 dimer interface [polypeptide binding]; other site 712961003163 conserved gate region; other site 712961003164 putative PBP binding loops; other site 712961003165 ABC-ATPase subunit interface; other site 712961003166 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 712961003167 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 712961003168 Switch I; other site 712961003169 Switch II; other site 712961003170 septum formation inhibitor; Reviewed; Region: minC; PRK00513 712961003171 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 712961003172 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 712961003173 rod shape-determining protein MreC; Provisional; Region: PRK13922 712961003174 rod shape-determining protein MreC; Region: MreC; pfam04085 712961003175 rod shape-determining protein MreB; Provisional; Region: PRK13927 712961003176 MreB and similar proteins; Region: MreB_like; cd10225 712961003177 nucleotide binding site [chemical binding]; other site 712961003178 Mg binding site [ion binding]; other site 712961003179 putative protofilament interaction site [polypeptide binding]; other site 712961003180 RodZ interaction site [polypeptide binding]; other site 712961003181 hypothetical protein; Reviewed; Region: PRK00024 712961003182 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 712961003183 MPN+ (JAMM) motif; other site 712961003184 Zinc-binding site [ion binding]; other site 712961003185 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 712961003186 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712961003187 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712961003188 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 712961003189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 712961003190 active site 712961003191 HIGH motif; other site 712961003192 nucleotide binding site [chemical binding]; other site 712961003193 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 712961003194 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 712961003195 active site 712961003196 KMSKS motif; other site 712961003197 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 712961003198 tRNA binding surface [nucleotide binding]; other site 712961003199 anticodon binding site; other site 712961003200 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 712961003201 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 712961003202 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 712961003203 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 712961003204 Ligand Binding Site [chemical binding]; other site 712961003205 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 712961003206 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 712961003207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712961003208 catalytic residue [active] 712961003209 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 712961003210 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 712961003211 GAF domain; Region: GAF_2; pfam13185 712961003212 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 712961003213 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 712961003214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961003215 RNA binding surface [nucleotide binding]; other site 712961003216 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 712961003217 recombination factor protein RarA; Reviewed; Region: PRK13342 712961003218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961003219 Walker A motif; other site 712961003220 ATP binding site [chemical binding]; other site 712961003221 Walker B motif; other site 712961003222 arginine finger; other site 712961003223 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 712961003224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 712961003225 Ligand Binding Site [chemical binding]; other site 712961003226 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 712961003227 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 712961003228 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 712961003229 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 712961003230 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 712961003231 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 712961003232 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 712961003233 active site 712961003234 Predicted membrane protein [Function unknown]; Region: COG2323 712961003235 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 712961003236 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 712961003237 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 712961003238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 712961003239 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 712961003240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961003241 active site 712961003242 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 712961003243 DHH family; Region: DHH; pfam01368 712961003244 DHHA1 domain; Region: DHHA1; pfam02272 712961003245 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 712961003246 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 712961003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961003248 NAD(P) binding site [chemical binding]; other site 712961003249 active site 712961003250 ribonuclease Z; Region: RNase_Z; TIGR02651 712961003251 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 712961003252 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 712961003253 catalytic triad [active] 712961003254 catalytic triad [active] 712961003255 oxyanion hole [active] 712961003256 GTPase CgtA; Reviewed; Region: obgE; PRK12297 712961003257 GTP1/OBG; Region: GTP1_OBG; pfam01018 712961003258 Obg GTPase; Region: Obg; cd01898 712961003259 G1 box; other site 712961003260 GTP/Mg2+ binding site [chemical binding]; other site 712961003261 Switch I region; other site 712961003262 G2 box; other site 712961003263 G3 box; other site 712961003264 Switch II region; other site 712961003265 G4 box; other site 712961003266 G5 box; other site 712961003267 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 712961003268 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 712961003269 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 712961003270 GIY-YIG motif/motif A; other site 712961003271 active site 712961003272 catalytic site [active] 712961003273 putative DNA binding site [nucleotide binding]; other site 712961003274 metal binding site [ion binding]; metal-binding site 712961003275 UvrB/uvrC motif; Region: UVR; pfam02151 712961003276 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 712961003277 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 712961003278 DNA binding site [nucleotide binding] 712961003279 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 712961003280 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 712961003281 putative ligand binding site [chemical binding]; other site 712961003282 putative NAD binding site [chemical binding]; other site 712961003283 catalytic site [active] 712961003284 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 712961003285 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712961003286 active site 712961003287 metal binding site [ion binding]; metal-binding site 712961003288 homotetramer interface [polypeptide binding]; other site 712961003289 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 712961003290 active site 712961003291 dimerization interface [polypeptide binding]; other site 712961003292 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 712961003293 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 712961003294 MutS domain III; Region: MutS_III; pfam05192 712961003295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961003296 Walker A/P-loop; other site 712961003297 ATP binding site [chemical binding]; other site 712961003298 Q-loop/lid; other site 712961003299 ABC transporter signature motif; other site 712961003300 Walker B; other site 712961003301 D-loop; other site 712961003302 H-loop/switch region; other site 712961003303 Smr domain; Region: Smr; pfam01713 712961003304 Colicin V production protein; Region: Colicin_V; pfam02674 712961003305 potential frameshift: common BLAST hit: gi|90962086|ref|YP_536002.1| alanyl-tRNA synthetase 712961003306 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 712961003307 DHHA1 domain; Region: DHHA1; pfam02272 712961003308 potential frameshift: common BLAST hit: gi|90962086|ref|YP_536002.1| alanyl-tRNA synthetase 712961003309 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 712961003310 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 712961003311 motif 1; other site 712961003312 active site 712961003313 motif 2; other site 712961003314 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 712961003315 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 712961003316 ATP binding site [chemical binding]; other site 712961003317 Mg++ binding site [ion binding]; other site 712961003318 motif III; other site 712961003319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003320 nucleotide binding region [chemical binding]; other site 712961003321 ATP-binding site [chemical binding]; other site 712961003322 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 712961003323 DHH family; Region: DHH; pfam01368 712961003324 DHHA1 domain; Region: DHHA1; pfam02272 712961003325 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 712961003326 propionate/acetate kinase; Provisional; Region: PRK12379 712961003327 Uncharacterized conserved protein [Function unknown]; Region: COG1556 712961003328 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 712961003329 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 712961003330 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 712961003331 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 712961003332 Cysteine-rich domain; Region: CCG; pfam02754 712961003333 Cysteine-rich domain; Region: CCG; pfam02754 712961003334 amino acid transporter; Region: 2A0306; TIGR00909 712961003335 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 712961003336 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 712961003337 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 712961003338 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 712961003339 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 712961003340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961003341 Walker A motif; other site 712961003342 ATP binding site [chemical binding]; other site 712961003343 Walker B motif; other site 712961003344 arginine finger; other site 712961003345 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 712961003346 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 712961003347 RuvA N terminal domain; Region: RuvA_N; pfam01330 712961003348 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 712961003349 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 712961003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961003351 ATP binding site [chemical binding]; other site 712961003352 Mg2+ binding site [ion binding]; other site 712961003353 G-X-G motif; other site 712961003354 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 712961003355 ATP binding site [chemical binding]; other site 712961003356 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 712961003357 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 712961003358 MutS domain I; Region: MutS_I; pfam01624 712961003359 MutS domain II; Region: MutS_II; pfam05188 712961003360 MutS domain III; Region: MutS_III; pfam05192 712961003361 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 712961003362 Walker A/P-loop; other site 712961003363 ATP binding site [chemical binding]; other site 712961003364 Q-loop/lid; other site 712961003365 ABC transporter signature motif; other site 712961003366 Walker B; other site 712961003367 D-loop; other site 712961003368 H-loop/switch region; other site 712961003369 ribonuclease Y; Region: RNase_Y; TIGR03319 712961003370 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 712961003371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961003372 Zn2+ binding site [ion binding]; other site 712961003373 Mg2+ binding site [ion binding]; other site 712961003374 recombinase A; Provisional; Region: recA; PRK09354 712961003375 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 712961003376 hexamer interface [polypeptide binding]; other site 712961003377 Walker A motif; other site 712961003378 ATP binding site [chemical binding]; other site 712961003379 Walker B motif; other site 712961003380 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 712961003381 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 712961003382 Helix-turn-helix domain; Region: HTH_25; pfam13413 712961003383 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 712961003384 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 712961003385 classical (c) SDRs; Region: SDR_c; cd05233 712961003386 NAD(P) binding site [chemical binding]; other site 712961003387 active site 712961003388 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 712961003389 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 712961003390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 712961003391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 712961003392 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 712961003393 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 712961003394 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 712961003395 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 712961003396 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 712961003397 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 712961003398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961003399 S-adenosylmethionine binding site [chemical binding]; other site 712961003400 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 712961003401 putative deacylase active site [active] 712961003402 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 712961003403 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 712961003404 active site 712961003405 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 712961003406 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 712961003407 CutC family; Region: CutC; cl01218 712961003408 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 712961003409 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 712961003410 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 712961003411 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 712961003412 active site 712961003413 substrate binding site [chemical binding]; other site 712961003414 metal binding site [ion binding]; metal-binding site 712961003415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 712961003416 YbbR-like protein; Region: YbbR; pfam07949 712961003417 YbbR-like protein; Region: YbbR; pfam07949 712961003418 Uncharacterized conserved protein [Function unknown]; Region: COG1624 712961003419 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 712961003420 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 712961003421 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 712961003422 FAD binding domain; Region: FAD_binding_4; pfam01565 712961003423 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 712961003424 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 712961003425 active site 712961003426 catalytic site [active] 712961003427 substrate binding site [chemical binding]; other site 712961003428 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 712961003429 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 712961003430 ligand binding site [chemical binding]; other site 712961003431 active site 712961003432 UGI interface [polypeptide binding]; other site 712961003433 catalytic site [active] 712961003434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961003435 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712961003436 active site 712961003437 motif I; other site 712961003438 motif II; other site 712961003439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 712961003440 motif II; other site 712961003441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961003442 Tubby C 2; Region: Tub_2; cl02043 712961003443 ribonuclease R; Region: RNase_R; TIGR02063 712961003444 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 712961003445 RNB domain; Region: RNB; pfam00773 712961003446 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 712961003447 RNA binding site [nucleotide binding]; other site 712961003448 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 712961003449 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 712961003450 Cl- selectivity filter; other site 712961003451 Cl- binding residues [ion binding]; other site 712961003452 pore gating glutamate residue; other site 712961003453 dimer interface [polypeptide binding]; other site 712961003454 H+/Cl- coupling transport residue; other site 712961003455 TrkA-C domain; Region: TrkA_C; pfam02080 712961003456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961003457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961003458 putative substrate translocation pore; other site 712961003459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712961003460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 712961003461 dimerization interface [polypeptide binding]; other site 712961003462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712961003463 dimer interface [polypeptide binding]; other site 712961003464 phosphorylation site [posttranslational modification] 712961003465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961003466 ATP binding site [chemical binding]; other site 712961003467 Mg2+ binding site [ion binding]; other site 712961003468 G-X-G motif; other site 712961003469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712961003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961003471 active site 712961003472 phosphorylation site [posttranslational modification] 712961003473 intermolecular recognition site; other site 712961003474 dimerization interface [polypeptide binding]; other site 712961003475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712961003476 DNA binding site [nucleotide binding] 712961003477 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 712961003478 active site 712961003479 DNA polymerase IV; Validated; Region: PRK02406 712961003480 DNA binding site [nucleotide binding] 712961003481 enolase; Provisional; Region: eno; PRK00077 712961003482 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 712961003483 dimer interface [polypeptide binding]; other site 712961003484 metal binding site [ion binding]; metal-binding site 712961003485 substrate binding pocket [chemical binding]; other site 712961003486 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 712961003487 triosephosphate isomerase; Provisional; Region: PRK14567 712961003488 substrate binding site [chemical binding]; other site 712961003489 dimer interface [polypeptide binding]; other site 712961003490 catalytic triad [active] 712961003491 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 712961003492 Phosphoglycerate kinase; Region: PGK; pfam00162 712961003493 substrate binding site [chemical binding]; other site 712961003494 hinge regions; other site 712961003495 ADP binding site [chemical binding]; other site 712961003496 catalytic site [active] 712961003497 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 712961003498 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 712961003499 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 712961003500 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 712961003501 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 712961003502 Clp protease; Region: CLP_protease; pfam00574 712961003503 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 712961003504 oligomer interface [polypeptide binding]; other site 712961003505 active site residues [active] 712961003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 712961003507 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 712961003508 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 712961003509 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 712961003510 phosphate binding site [ion binding]; other site 712961003511 putative substrate binding pocket [chemical binding]; other site 712961003512 dimer interface [polypeptide binding]; other site 712961003513 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 712961003514 shikimate kinase; Reviewed; Region: aroK; PRK00131 712961003515 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 712961003516 NADH(P)-binding; Region: NAD_binding_10; pfam13460 712961003517 NAD(P) binding site [chemical binding]; other site 712961003518 putative active site [active] 712961003519 S-ribosylhomocysteinase; Provisional; Region: PRK02260 712961003520 potential frameshift: common BLAST hit: gi|90962149|ref|YP_536065.1| excinuclease ABC subunit A 712961003521 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 712961003522 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 712961003523 AAA domain; Region: AAA_21; pfam13304 712961003524 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 712961003525 excinuclease ABC subunit B; Provisional; Region: PRK05298 712961003526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961003527 ATP binding site [chemical binding]; other site 712961003528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003529 nucleotide binding region [chemical binding]; other site 712961003530 ATP-binding site [chemical binding]; other site 712961003531 Ultra-violet resistance protein B; Region: UvrB; pfam12344 712961003532 UvrB/uvrC motif; Region: UVR; pfam02151 712961003533 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 712961003534 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 712961003535 active site 712961003536 substrate binding site [chemical binding]; other site 712961003537 metal binding site [ion binding]; metal-binding site 712961003538 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 712961003539 HPr kinase/phosphorylase; Provisional; Region: PRK05428 712961003540 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 712961003541 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 712961003542 Hpr binding site; other site 712961003543 active site 712961003544 homohexamer subunit interaction site [polypeptide binding]; other site 712961003545 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 712961003546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712961003547 dimer interface [polypeptide binding]; other site 712961003548 phosphorylation site [posttranslational modification] 712961003549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961003550 ATP binding site [chemical binding]; other site 712961003551 Mg2+ binding site [ion binding]; other site 712961003552 G-X-G motif; other site 712961003553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712961003554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961003555 active site 712961003556 phosphorylation site [posttranslational modification] 712961003557 intermolecular recognition site; other site 712961003558 dimerization interface [polypeptide binding]; other site 712961003559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712961003560 DNA binding site [nucleotide binding] 712961003561 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 712961003562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961003563 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961003564 peptide chain release factor 2; Validated; Region: prfB; PRK00578 712961003565 This domain is found in peptide chain release factors; Region: PCRF; smart00937 712961003566 RF-1 domain; Region: RF-1; pfam00472 712961003567 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 712961003568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712961003569 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 712961003570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003571 nucleotide binding region [chemical binding]; other site 712961003572 ATP-binding site [chemical binding]; other site 712961003573 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 712961003574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961003575 putative substrate translocation pore; other site 712961003576 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 712961003577 30S subunit binding site; other site 712961003578 potential frameshift: common BLAST hit: gi|90962164|ref|YP_536080.1| phage integrase 712961003579 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961003580 Int/Topo IB signature motif; other site 712961003581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712961003582 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712961003583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961003584 non-specific DNA binding site [nucleotide binding]; other site 712961003585 salt bridge; other site 712961003586 sequence-specific DNA binding site [nucleotide binding]; other site 712961003587 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 712961003588 polymerase nucleotide-binding site; other site 712961003589 DNA-binding residues [nucleotide binding]; DNA binding site 712961003590 nucleotide binding site [chemical binding]; other site 712961003591 primase nucleotide-binding site [nucleotide binding]; other site 712961003592 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 712961003593 D5 N terminal like; Region: D5_N; smart00885 712961003594 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 712961003595 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 712961003596 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 712961003597 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 712961003598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961003599 active site 712961003600 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 712961003601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961003602 ATP binding site [chemical binding]; other site 712961003603 putative Mg++ binding site [ion binding]; other site 712961003604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003605 nucleotide binding region [chemical binding]; other site 712961003606 ATP-binding site [chemical binding]; other site 712961003607 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 712961003608 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 712961003609 Mg++ binding site [ion binding]; other site 712961003610 putative catalytic motif [active] 712961003611 substrate binding site [chemical binding]; other site 712961003612 Amino acid permease; Region: AA_permease_2; pfam13520 712961003613 K+ potassium transporter; Region: K_trans; cl15781 712961003614 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 712961003615 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961003616 Soluble P-type ATPase [General function prediction only]; Region: COG4087 712961003617 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 712961003618 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 712961003619 ring oligomerisation interface [polypeptide binding]; other site 712961003620 ATP/Mg binding site [chemical binding]; other site 712961003621 stacking interactions; other site 712961003622 hinge regions; other site 712961003623 CAAX protease self-immunity; Region: Abi; pfam02517 712961003624 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 712961003625 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 712961003626 CoA binding domain; Region: CoA_binding; pfam02629 712961003627 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712961003628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961003629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961003630 ABC transporter; Region: ABC_tran_2; pfam12848 712961003631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712961003632 UGMP family protein; Validated; Region: PRK09604 712961003633 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 712961003634 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 712961003635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961003636 Coenzyme A binding pocket [chemical binding]; other site 712961003637 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 712961003638 Glycoprotease family; Region: Peptidase_M22; pfam00814 712961003639 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 712961003640 active site 712961003641 homotetramer interface [polypeptide binding]; other site 712961003642 homodimer interface [polypeptide binding]; other site 712961003643 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 712961003644 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 712961003645 active site 712961003646 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 712961003647 active site 712961003648 Predicted methyltransferases [General function prediction only]; Region: COG0313 712961003649 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 712961003650 putative SAM binding site [chemical binding]; other site 712961003651 putative homodimer interface [polypeptide binding]; other site 712961003652 DNA polymerase III subunit delta'; Validated; Region: PRK08058 712961003653 DNA polymerase III subunit delta'; Validated; Region: PRK08485 712961003654 thymidylate kinase; Validated; Region: tmk; PRK00698 712961003655 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 712961003656 TMP-binding site; other site 712961003657 ATP-binding site [chemical binding]; other site 712961003658 recombination protein RecR; Reviewed; Region: recR; PRK00076 712961003659 RecR protein; Region: RecR; pfam02132 712961003660 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 712961003661 putative active site [active] 712961003662 putative metal-binding site [ion binding]; other site 712961003663 tetramer interface [polypeptide binding]; other site 712961003664 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 712961003665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961003666 Walker A motif; other site 712961003667 ATP binding site [chemical binding]; other site 712961003668 Walker B motif; other site 712961003669 arginine finger; other site 712961003670 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 712961003671 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 712961003672 nucleoside/Zn binding site; other site 712961003673 dimer interface [polypeptide binding]; other site 712961003674 catalytic motif [active] 712961003675 Methyltransferase domain; Region: Methyltransf_31; pfam13847 712961003676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961003677 S-adenosylmethionine binding site [chemical binding]; other site 712961003678 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 712961003679 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 712961003680 Class I ribonucleotide reductase; Region: RNR_I; cd01679 712961003681 active site 712961003682 dimer interface [polypeptide binding]; other site 712961003683 catalytic residues [active] 712961003684 effector binding site; other site 712961003685 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 712961003686 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 712961003687 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 712961003688 dimer interface [polypeptide binding]; other site 712961003689 putative radical transfer pathway; other site 712961003690 diiron center [ion binding]; other site 712961003691 tyrosyl radical; other site 712961003692 Predicted integral membrane protein [Function unknown]; Region: COG0392 712961003693 Uncharacterized conserved protein [Function unknown]; Region: COG2898 712961003694 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 712961003695 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 712961003696 23S rRNA interface [nucleotide binding]; other site 712961003697 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 712961003698 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 712961003699 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 712961003700 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 712961003701 putative homodimer interface [polypeptide binding]; other site 712961003702 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 712961003703 heterodimer interface [polypeptide binding]; other site 712961003704 homodimer interface [polypeptide binding]; other site 712961003705 YacP-like NYN domain; Region: NYN_YacP; pfam05991 712961003706 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 712961003707 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 712961003708 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 712961003709 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 712961003710 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 712961003711 active site 712961003712 HIGH motif; other site 712961003713 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 712961003714 KMSKS motif; other site 712961003715 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 712961003716 tRNA binding surface [nucleotide binding]; other site 712961003717 anticodon binding site; other site 712961003718 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 712961003719 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 712961003720 HIGH motif; other site 712961003721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 712961003722 active site 712961003723 KMSKS motif; other site 712961003724 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 712961003725 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 712961003726 putative active site [active] 712961003727 DNA repair protein RadA; Provisional; Region: PRK11823 712961003728 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 712961003729 Walker A motif/ATP binding site; other site 712961003730 ATP binding site [chemical binding]; other site 712961003731 Walker B motif; other site 712961003732 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 712961003733 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 712961003734 trimer interface [polypeptide binding]; other site 712961003735 active site 712961003736 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 712961003737 trimer interface [polypeptide binding]; other site 712961003738 active site 712961003739 G bulge; other site 712961003740 Enterocin A Immunity; Region: EntA_Immun; pfam08951 712961003741 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961003742 catalytic core [active] 712961003743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961003744 Membrane transport protein; Region: Mem_trans; pfam03547 712961003745 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 712961003746 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 712961003747 dimer interface [polypeptide binding]; other site 712961003748 active site 712961003749 CoA binding pocket [chemical binding]; other site 712961003750 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 712961003751 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 712961003752 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 712961003753 RNA binding site [nucleotide binding]; other site 712961003754 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 712961003755 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 712961003756 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 712961003757 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 712961003758 homodimer interface [polypeptide binding]; other site 712961003759 NAD binding pocket [chemical binding]; other site 712961003760 ATP binding pocket [chemical binding]; other site 712961003761 Mg binding site [ion binding]; other site 712961003762 active-site loop [active] 712961003763 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 712961003764 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 712961003765 active site 712961003766 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 712961003767 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 712961003768 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 712961003769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 712961003770 DNA-binding site [nucleotide binding]; DNA binding site 712961003771 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 712961003772 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 712961003773 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 712961003774 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 712961003775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961003776 putative substrate translocation pore; other site 712961003777 POT family; Region: PTR2; cl17359 712961003778 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 712961003779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712961003780 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 712961003781 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 712961003782 active site 712961003783 tetramer interface; other site 712961003784 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 712961003785 active site 712961003786 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 712961003787 ornithine cyclodeaminase; Validated; Region: PRK08618 712961003788 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 712961003789 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 712961003790 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 712961003791 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 712961003792 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 712961003793 C-terminal domain interface [polypeptide binding]; other site 712961003794 sugar binding site [chemical binding]; other site 712961003795 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 712961003796 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 712961003797 active site 712961003798 homodimer interface [polypeptide binding]; other site 712961003799 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 712961003800 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 712961003801 Amino acid permease; Region: AA_permease_2; pfam13520 712961003802 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 712961003803 beta-phosphoglucomutase; Region: bPGM; TIGR01990 712961003804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961003805 motif II; other site 712961003806 maltose phosphorylase; Provisional; Region: PRK13807 712961003807 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 712961003808 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 712961003809 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 712961003810 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 712961003811 active site 712961003812 catalytic residues [active] 712961003813 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 712961003814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961003815 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712961003816 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712961003817 DNA binding site [nucleotide binding] 712961003818 domain linker motif; other site 712961003819 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 712961003820 putative dimerization interface [polypeptide binding]; other site 712961003821 putative ligand binding site [chemical binding]; other site 712961003822 K+ potassium transporter; Region: K_trans; pfam02705 712961003823 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712961003824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712961003825 ATP binding site [chemical binding]; other site 712961003826 putative Mg++ binding site [ion binding]; other site 712961003827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961003828 nucleotide binding region [chemical binding]; other site 712961003829 ATP-binding site [chemical binding]; other site 712961003830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 712961003831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 712961003832 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 712961003833 active site 712961003834 homodimer interface [polypeptide binding]; other site 712961003835 catalytic site [active] 712961003836 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 712961003837 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 712961003838 homodimer interface [polypeptide binding]; other site 712961003839 active site pocket [active] 712961003840 glycogen synthase; Provisional; Region: glgA; PRK00654 712961003841 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 712961003842 ADP-binding pocket [chemical binding]; other site 712961003843 homodimer interface [polypeptide binding]; other site 712961003844 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 712961003845 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 712961003846 ligand binding site; other site 712961003847 oligomer interface; other site 712961003848 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 712961003849 dimer interface [polypeptide binding]; other site 712961003850 N-terminal domain interface [polypeptide binding]; other site 712961003851 sulfate 1 binding site; other site 712961003852 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 712961003853 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 712961003854 ligand binding site; other site 712961003855 oligomer interface; other site 712961003856 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 712961003857 dimer interface [polypeptide binding]; other site 712961003858 N-terminal domain interface [polypeptide binding]; other site 712961003859 glycogen branching enzyme; Provisional; Region: PRK12313 712961003860 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 712961003861 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 712961003862 active site 712961003863 catalytic site [active] 712961003864 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 712961003865 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 712961003866 homodimer interface [polypeptide binding]; other site 712961003867 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 712961003868 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 712961003869 active site 712961003870 homodimer interface [polypeptide binding]; other site 712961003871 catalytic site [active] 712961003872 glutamate dehydrogenase; Provisional; Region: PRK09414 712961003873 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 712961003874 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 712961003875 NAD(P) binding site [chemical binding]; other site 712961003876 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 712961003877 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 712961003878 NAD(P) binding site [chemical binding]; other site 712961003879 catalytic residues [active] 712961003880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961003881 Coenzyme A binding pocket [chemical binding]; other site 712961003882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961003883 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961003884 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 712961003885 MgtE intracellular N domain; Region: MgtE_N; pfam03448 712961003886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 712961003887 Divalent cation transporter; Region: MgtE; pfam01769 712961003888 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712961003889 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712961003890 active site 712961003891 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 712961003892 ATP-NAD kinase; Region: NAD_kinase; pfam01513 712961003893 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 712961003894 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 712961003895 synthetase active site [active] 712961003896 NTP binding site [chemical binding]; other site 712961003897 metal binding site [ion binding]; metal-binding site 712961003898 DNA topoisomerase III; Provisional; Region: PRK07726 712961003899 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 712961003900 active site 712961003901 putative interdomain interaction site [polypeptide binding]; other site 712961003902 putative metal-binding site [ion binding]; other site 712961003903 putative nucleotide binding site [chemical binding]; other site 712961003904 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 712961003905 domain I; other site 712961003906 DNA binding groove [nucleotide binding] 712961003907 phosphate binding site [ion binding]; other site 712961003908 domain II; other site 712961003909 domain III; other site 712961003910 nucleotide binding site [chemical binding]; other site 712961003911 catalytic site [active] 712961003912 domain IV; other site 712961003913 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712961003914 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 712961003915 active site 712961003916 substrate binding site [chemical binding]; other site 712961003917 trimer interface [polypeptide binding]; other site 712961003918 CoA binding site [chemical binding]; other site 712961003919 xanthine permease; Region: pbuX; TIGR03173 712961003920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961003921 active site 712961003922 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 712961003923 Predicted membrane protein [Function unknown]; Region: COG4684 712961003924 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 712961003925 Membrane transport protein; Region: Mem_trans; cl09117 712961003926 malate dehydrogenase; Provisional; Region: PRK13529 712961003927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 712961003928 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 712961003929 NAD(P) binding site [chemical binding]; other site 712961003930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961003931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961003932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 712961003933 dimerization interface [polypeptide binding]; other site 712961003934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961003935 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 712961003936 DNA-binding interface [nucleotide binding]; DNA binding site 712961003937 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 712961003938 Ligand Binding Site [chemical binding]; other site 712961003939 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 712961003940 Penicillinase repressor; Region: Pencillinase_R; pfam03965 712961003941 Predicted secreted protein [Function unknown]; Region: COG4086 712961003942 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 712961003943 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 712961003944 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 712961003945 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 712961003946 propionate/acetate kinase; Provisional; Region: PRK12379 712961003947 maltose O-acetyltransferase; Provisional; Region: PRK10092 712961003948 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 712961003949 putative trimer interface [polypeptide binding]; other site 712961003950 putative CoA binding site [chemical binding]; other site 712961003951 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 712961003952 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 712961003953 transmembrane helices; other site 712961003954 L-aspartate oxidase; Provisional; Region: PRK06175 712961003955 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 712961003956 fumarate hydratase; Reviewed; Region: fumC; PRK00485 712961003957 Class II fumarases; Region: Fumarase_classII; cd01362 712961003958 active site 712961003959 tetramer interface [polypeptide binding]; other site 712961003960 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 712961003961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961003962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712961003963 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 712961003964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 712961003965 FeS/SAM binding site; other site 712961003966 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 712961003967 ATP cone domain; Region: ATP-cone; pfam03477 712961003968 Class III ribonucleotide reductase; Region: RNR_III; cd01675 712961003969 effector binding site; other site 712961003970 active site 712961003971 Zn binding site [ion binding]; other site 712961003972 glycine loop; other site 712961003973 hypothetical protein; Provisional; Region: PRK13690 712961003974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 712961003975 Coenzyme A binding pocket [chemical binding]; other site 712961003976 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712961003977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961003978 non-specific DNA binding site [nucleotide binding]; other site 712961003979 salt bridge; other site 712961003980 sequence-specific DNA binding site [nucleotide binding]; other site 712961003981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961003982 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961003983 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 712961003984 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 712961003985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961003986 S-adenosylmethionine binding site [chemical binding]; other site 712961003987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961003988 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961003989 putative lipid kinase; Reviewed; Region: PRK13055 712961003990 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 712961003991 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 712961003992 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 712961003993 GatB domain; Region: GatB_Yqey; smart00845 712961003994 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 712961003995 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 712961003996 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 712961003997 putative dimer interface [polypeptide binding]; other site 712961003998 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 712961003999 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 712961004000 putative dimer interface [polypeptide binding]; other site 712961004001 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 712961004002 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 712961004003 nucleotide binding pocket [chemical binding]; other site 712961004004 K-X-D-G motif; other site 712961004005 catalytic site [active] 712961004006 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 712961004007 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 712961004008 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 712961004009 Dimer interface [polypeptide binding]; other site 712961004010 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 712961004011 Part of AAA domain; Region: AAA_19; pfam13245 712961004012 Family description; Region: UvrD_C_2; pfam13538 712961004013 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 712961004014 NAD binding site [chemical binding]; other site 712961004015 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712961004016 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 712961004017 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 712961004018 dimer interface [polypeptide binding]; other site 712961004019 putative anticodon binding site; other site 712961004020 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 712961004021 motif 1; other site 712961004022 active site 712961004023 motif 2; other site 712961004024 motif 3; other site 712961004025 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 712961004026 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 712961004027 FMN binding site [chemical binding]; other site 712961004028 active site 712961004029 catalytic residues [active] 712961004030 substrate binding site [chemical binding]; other site 712961004031 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 712961004032 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 712961004033 dimerization interface [polypeptide binding]; other site 712961004034 domain crossover interface; other site 712961004035 redox-dependent activation switch; other site 712961004036 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 712961004037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961004038 Walker A motif; other site 712961004039 ATP binding site [chemical binding]; other site 712961004040 Walker B motif; other site 712961004041 arginine finger; other site 712961004042 Peptidase family M41; Region: Peptidase_M41; pfam01434 712961004043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961004044 active site 712961004045 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 712961004046 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 712961004047 Ligand Binding Site [chemical binding]; other site 712961004048 TilS substrate C-terminal domain; Region: TilS_C; smart00977 712961004049 hypothetical protein; Provisional; Region: PRK08582 712961004050 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 712961004051 RNA binding site [nucleotide binding]; other site 712961004052 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 712961004053 potential frameshift: common BLAST hit: gi|90962332|ref|YP_536248.1| transcription-repair coupling factor 712961004054 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 712961004055 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712961004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961004057 ATP binding site [chemical binding]; other site 712961004058 putative Mg++ binding site [ion binding]; other site 712961004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961004060 nucleotide binding region [chemical binding]; other site 712961004061 ATP-binding site [chemical binding]; other site 712961004062 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 712961004063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 712961004064 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 712961004065 putative active site [active] 712961004066 catalytic residue [active] 712961004067 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 712961004068 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712961004069 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712961004070 NAD binding site [chemical binding]; other site 712961004071 dimer interface [polypeptide binding]; other site 712961004072 substrate binding site [chemical binding]; other site 712961004073 Restriction endonuclease; Region: Mrr_cat; pfam04471 712961004074 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 712961004075 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 712961004076 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 712961004077 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 712961004078 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 712961004079 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 712961004080 active site 712961004081 HIGH motif; other site 712961004082 dimer interface [polypeptide binding]; other site 712961004083 KMSKS motif; other site 712961004084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712961004085 RNA binding surface [nucleotide binding]; other site 712961004086 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 712961004087 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 712961004088 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 712961004089 Walker A/P-loop; other site 712961004090 ATP binding site [chemical binding]; other site 712961004091 Q-loop/lid; other site 712961004092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004093 ABC transporter signature motif; other site 712961004094 Walker B; other site 712961004095 D-loop; other site 712961004096 H-loop/switch region; other site 712961004097 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 712961004098 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712961004099 active site 712961004100 metal binding site [ion binding]; metal-binding site 712961004101 DNA binding site [nucleotide binding] 712961004102 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 712961004103 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 712961004104 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 712961004105 PYR/PP interface [polypeptide binding]; other site 712961004106 dimer interface [polypeptide binding]; other site 712961004107 tetramer interface [polypeptide binding]; other site 712961004108 TPP binding site [chemical binding]; other site 712961004109 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 712961004110 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 712961004111 TPP-binding site [chemical binding]; other site 712961004112 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 712961004113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712961004114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961004115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 712961004116 Walker A/P-loop; other site 712961004117 ATP binding site [chemical binding]; other site 712961004118 Q-loop/lid; other site 712961004119 ABC transporter signature motif; other site 712961004120 Walker B; other site 712961004121 D-loop; other site 712961004122 H-loop/switch region; other site 712961004123 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 712961004124 dimer interface [polypeptide binding]; other site 712961004125 FMN binding site [chemical binding]; other site 712961004126 NADPH bind site [chemical binding]; other site 712961004127 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 712961004128 Part of AAA domain; Region: AAA_19; pfam13245 712961004129 Family description; Region: UvrD_C_2; pfam13538 712961004130 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 712961004131 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 712961004132 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 712961004133 TrkA-N domain; Region: TrkA_N; pfam02254 712961004134 TrkA-C domain; Region: TrkA_C; pfam02080 712961004135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 712961004136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 712961004137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961004138 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961004139 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 712961004140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 712961004141 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 712961004142 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 712961004143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712961004144 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 712961004145 Walker A/P-loop; other site 712961004146 ATP binding site [chemical binding]; other site 712961004147 Q-loop/lid; other site 712961004148 ABC transporter signature motif; other site 712961004149 Walker B; other site 712961004150 D-loop; other site 712961004151 H-loop/switch region; other site 712961004152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961004153 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961004154 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 712961004155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004156 AAA domain; Region: AAA_23; pfam13476 712961004157 Walker A/P-loop; other site 712961004158 ATP binding site [chemical binding]; other site 712961004159 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712961004160 Helix-turn-helix domain; Region: HTH_38; pfam13936 712961004161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961004162 short chain dehydrogenase; Provisional; Region: PRK06197 712961004163 NAD(P) binding site [chemical binding]; other site 712961004164 active site 712961004165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 712961004166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 712961004167 putative active site [active] 712961004168 putative metal binding site [ion binding]; other site 712961004169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 712961004170 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 712961004171 active site 712961004172 Cna protein B-type domain; Region: Cna_B; pfam05738 712961004173 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961004174 domain interaction interfaces [polypeptide binding]; other site 712961004175 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961004176 domain interaction interfaces [polypeptide binding]; other site 712961004177 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 712961004178 T surface-antigen of pili; Region: FctA; cl16948 712961004179 T surface-antigen of pili; Region: FctA; cl16948 712961004180 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961004181 domain interaction interfaces [polypeptide binding]; other site 712961004182 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961004183 domain interaction interfaces [polypeptide binding]; other site 712961004184 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 712961004185 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 712961004186 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 712961004187 NAD(P) binding site [chemical binding]; other site 712961004188 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 712961004189 23S rRNA interface [nucleotide binding]; other site 712961004190 L3 interface [polypeptide binding]; other site 712961004191 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 712961004192 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 712961004193 dimerization interface 3.5A [polypeptide binding]; other site 712961004194 active site 712961004195 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 712961004196 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 712961004197 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712961004198 Walker A/P-loop; other site 712961004199 ATP binding site [chemical binding]; other site 712961004200 Q-loop/lid; other site 712961004201 ABC transporter signature motif; other site 712961004202 Walker B; other site 712961004203 D-loop; other site 712961004204 H-loop/switch region; other site 712961004205 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 712961004206 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712961004207 Walker A/P-loop; other site 712961004208 ATP binding site [chemical binding]; other site 712961004209 Q-loop/lid; other site 712961004210 ABC transporter signature motif; other site 712961004211 Walker B; other site 712961004212 D-loop; other site 712961004213 H-loop/switch region; other site 712961004214 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 712961004215 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 712961004216 alphaNTD homodimer interface [polypeptide binding]; other site 712961004217 alphaNTD - beta interaction site [polypeptide binding]; other site 712961004218 alphaNTD - beta' interaction site [polypeptide binding]; other site 712961004219 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 712961004220 adenylate kinase; Reviewed; Region: adk; PRK00279 712961004221 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 712961004222 AMP-binding site [chemical binding]; other site 712961004223 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 712961004224 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 712961004225 SecY translocase; Region: SecY; pfam00344 712961004226 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 712961004227 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 712961004228 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 712961004229 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 712961004230 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 712961004231 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 712961004232 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 712961004233 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 712961004234 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 712961004235 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 712961004236 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 712961004237 G-X-X-G motif; other site 712961004238 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 712961004239 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 712961004240 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 712961004241 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 712961004242 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 712961004243 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 712961004244 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 712961004245 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 712961004246 HflX GTPase family; Region: HflX; cd01878 712961004247 G1 box; other site 712961004248 GTP/Mg2+ binding site [chemical binding]; other site 712961004249 Switch I region; other site 712961004250 G2 box; other site 712961004251 G3 box; other site 712961004252 Switch II region; other site 712961004253 G4 box; other site 712961004254 G5 box; other site 712961004255 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 712961004256 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 712961004257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 712961004258 putative active site [active] 712961004259 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 712961004260 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712961004261 active site 712961004262 dimer interface [polypeptide binding]; other site 712961004263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 712961004264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 712961004265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 712961004266 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 712961004267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 712961004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004269 dimer interface [polypeptide binding]; other site 712961004270 conserved gate region; other site 712961004271 putative PBP binding loops; other site 712961004272 ABC-ATPase subunit interface; other site 712961004273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 712961004274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004275 dimer interface [polypeptide binding]; other site 712961004276 conserved gate region; other site 712961004277 putative PBP binding loops; other site 712961004278 ABC-ATPase subunit interface; other site 712961004279 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961004280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961004281 substrate binding pocket [chemical binding]; other site 712961004282 membrane-bound complex binding site; other site 712961004283 hinge residues; other site 712961004284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712961004285 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 712961004286 Walker A/P-loop; other site 712961004287 ATP binding site [chemical binding]; other site 712961004288 Q-loop/lid; other site 712961004289 ABC transporter signature motif; other site 712961004290 Walker B; other site 712961004291 D-loop; other site 712961004292 H-loop/switch region; other site 712961004293 amino acid transporter; Region: 2A0306; TIGR00909 712961004294 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712961004295 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 712961004296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 712961004297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 712961004298 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 712961004299 active site 712961004300 potential frameshift: common BLAST hit: gi|90962424|ref|YP_536340.1| DNA/RNA helicase 712961004301 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 712961004302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961004303 ATP binding site [chemical binding]; other site 712961004304 putative Mg++ binding site [ion binding]; other site 712961004305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712961004306 nucleotide binding region [chemical binding]; other site 712961004307 ATP-binding site [chemical binding]; other site 712961004308 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 712961004309 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 712961004310 PLD-like domain; Region: PLDc_2; pfam13091 712961004311 putative homodimer interface [polypeptide binding]; other site 712961004312 putative active site [active] 712961004313 catalytic site [active] 712961004314 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 712961004315 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 712961004316 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 712961004317 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 712961004318 Domain of unknown function DUF21; Region: DUF21; pfam01595 712961004319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 712961004320 Transporter associated domain; Region: CorC_HlyC; smart01091 712961004321 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712961004322 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712961004323 active site 712961004324 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712961004325 FtsX-like permease family; Region: FtsX; pfam02687 712961004326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961004327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 712961004328 Walker A/P-loop; other site 712961004329 ATP binding site [chemical binding]; other site 712961004330 Q-loop/lid; other site 712961004331 ABC transporter signature motif; other site 712961004332 Walker B; other site 712961004333 D-loop; other site 712961004334 H-loop/switch region; other site 712961004335 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 712961004336 HlyD family secretion protein; Region: HlyD_3; pfam13437 712961004337 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 712961004338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712961004339 nucleotide binding site [chemical binding]; other site 712961004340 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 712961004341 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 712961004342 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 712961004343 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 712961004344 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 712961004345 active site 712961004346 trimer interface [polypeptide binding]; other site 712961004347 allosteric site; other site 712961004348 active site lid [active] 712961004349 hexamer (dimer of trimers) interface [polypeptide binding]; other site 712961004350 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 712961004351 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 712961004352 active site 712961004353 dimer interface [polypeptide binding]; other site 712961004354 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 712961004355 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 712961004356 metal binding site [ion binding]; metal-binding site 712961004357 dimer interface [polypeptide binding]; other site 712961004358 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 712961004359 classical (c) SDRs; Region: SDR_c; cd05233 712961004360 NAD(P) binding site [chemical binding]; other site 712961004361 active site 712961004362 QueT transporter; Region: QueT; pfam06177 712961004363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961004364 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 712961004366 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712961004367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004368 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712961004369 active site 712961004370 motif I; other site 712961004371 motif II; other site 712961004372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004373 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961004374 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 712961004375 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 712961004376 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 712961004377 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 712961004378 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 712961004379 FeoA domain; Region: FeoA; pfam04023 712961004380 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712961004381 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712961004382 active site 712961004383 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 712961004384 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 712961004385 active site 712961004386 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 712961004387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 712961004388 AzlC protein; Region: AzlC; pfam03591 712961004389 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 712961004390 active site 712961004391 putative catalytic site [active] 712961004392 DNA binding site [nucleotide binding] 712961004393 putative phosphate binding site [ion binding]; other site 712961004394 metal binding site A [ion binding]; metal-binding site 712961004395 AP binding site [nucleotide binding]; other site 712961004396 metal binding site B [ion binding]; metal-binding site 712961004397 potential frameshift: common BLAST hit: gi|81429412|ref|YP_396413.1| autotransport protein 712961004398 Predicted membrane protein [Function unknown]; Region: COG1511 712961004399 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 712961004400 Predicted membrane protein [Function unknown]; Region: COG1511 712961004401 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 712961004402 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 712961004403 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 712961004404 Double zinc ribbon; Region: DZR; pfam12773 712961004405 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 712961004406 Double zinc ribbon; Region: DZR; pfam12773 712961004407 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961004408 catalytic core [active] 712961004409 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961004410 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961004411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961004412 homodimer interface [polypeptide binding]; other site 712961004413 catalytic residue [active] 712961004414 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 712961004415 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 712961004416 EamA-like transporter family; Region: EamA; pfam00892 712961004417 EamA-like transporter family; Region: EamA; pfam00892 712961004418 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 712961004419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004420 motif II; other site 712961004421 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 712961004422 active site 712961004423 catalytic residues [active] 712961004424 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 712961004425 Predicted flavoprotein [General function prediction only]; Region: COG0431 712961004426 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 712961004427 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 712961004428 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 712961004429 UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179 712961004430 NAD binding site [chemical binding]; other site 712961004431 homodimer interface [polypeptide binding]; other site 712961004432 active site 712961004433 substrate binding site [chemical binding]; other site 712961004434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 712961004435 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 712961004436 DNA-binding site [nucleotide binding]; DNA binding site 712961004437 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 712961004438 putative phosphoketolase; Provisional; Region: PRK05261 712961004439 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 712961004440 TPP-binding site; other site 712961004441 XFP C-terminal domain; Region: XFP_C; pfam09363 712961004442 Isochorismatase family; Region: Isochorismatase; pfam00857 712961004443 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 712961004444 catalytic triad [active] 712961004445 conserved cis-peptide bond; other site 712961004446 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961004447 catalytic core [active] 712961004448 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 712961004449 HPr interaction site; other site 712961004450 glycerol kinase (GK) interaction site [polypeptide binding]; other site 712961004451 active site 712961004452 phosphorylation site [posttranslational modification] 712961004453 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 712961004454 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 712961004455 active site turn [active] 712961004456 phosphorylation site [posttranslational modification] 712961004457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 712961004458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 712961004459 DNA-binding site [nucleotide binding]; DNA binding site 712961004460 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 712961004461 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 712961004462 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 712961004463 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 712961004464 Ca binding site [ion binding]; other site 712961004465 active site 712961004466 catalytic site [active] 712961004467 drug efflux system protein MdtG; Provisional; Region: PRK09874 712961004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961004469 putative substrate translocation pore; other site 712961004470 Sulfatase; Region: Sulfatase; pfam00884 712961004471 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004472 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004473 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 712961004474 amidase catalytic site [active] 712961004475 Zn binding residues [ion binding]; other site 712961004476 substrate binding site [chemical binding]; other site 712961004477 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004478 homoserine kinase; Provisional; Region: PRK01212 712961004479 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712961004480 homoserine dehydrogenase; Provisional; Region: PRK06349 712961004481 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 712961004482 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 712961004483 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 712961004484 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 712961004485 ApbE family; Region: ApbE; pfam02424 712961004486 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 712961004487 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 712961004488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961004489 catalytic residue [active] 712961004490 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 712961004491 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004492 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004493 Predicted integral membrane protein [Function unknown]; Region: COG5617 712961004494 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 712961004495 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712961004496 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 712961004497 Sulfatase; Region: Sulfatase; cl17466 712961004498 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 712961004499 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 712961004500 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 712961004501 Acyltransferase family; Region: Acyl_transf_3; pfam01757 712961004502 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 712961004503 active site 712961004504 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 712961004505 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 712961004506 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 712961004507 PAS domain; Region: PAS_10; pfam13596 712961004508 Predicted flavoprotein [General function prediction only]; Region: COG0431 712961004509 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 712961004510 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 712961004511 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 712961004512 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 712961004513 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 712961004514 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 712961004515 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 712961004516 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 712961004517 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004518 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 712961004519 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 712961004520 putative active site [active] 712961004521 conserved hypothetical integral membrane protein; Region: TIGR03766 712961004522 GMP synthase; Reviewed; Region: guaA; PRK00074 712961004523 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 712961004524 AMP/PPi binding site [chemical binding]; other site 712961004525 candidate oxyanion hole; other site 712961004526 catalytic triad [active] 712961004527 potential glutamine specificity residues [chemical binding]; other site 712961004528 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 712961004529 ATP Binding subdomain [chemical binding]; other site 712961004530 Dimerization subdomain; other site 712961004531 pantothenate kinase; Provisional; Region: PRK05439 712961004532 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 712961004533 ATP-binding site [chemical binding]; other site 712961004534 CoA-binding site [chemical binding]; other site 712961004535 Mg2+-binding site [ion binding]; other site 712961004536 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 712961004537 active site 712961004538 catalytic triad [active] 712961004539 oxyanion hole [active] 712961004540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 712961004541 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712961004542 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 712961004543 Walker A/P-loop; other site 712961004544 ATP binding site [chemical binding]; other site 712961004545 Q-loop/lid; other site 712961004546 ABC transporter signature motif; other site 712961004547 Walker B; other site 712961004548 D-loop; other site 712961004549 H-loop/switch region; other site 712961004550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961004551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961004552 substrate binding pocket [chemical binding]; other site 712961004553 membrane-bound complex binding site; other site 712961004554 hinge residues; other site 712961004555 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 712961004556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004557 dimer interface [polypeptide binding]; other site 712961004558 conserved gate region; other site 712961004559 putative PBP binding loops; other site 712961004560 ABC-ATPase subunit interface; other site 712961004561 inner membrane transporter YjeM; Provisional; Region: PRK15238 712961004562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961004563 putative substrate translocation pore; other site 712961004564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961004565 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 712961004566 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004567 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712961004568 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 712961004569 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 712961004570 Peptidase family M23; Region: Peptidase_M23; pfam01551 712961004571 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 712961004572 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 712961004573 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 712961004574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 712961004575 UDP-galactopyranose mutase; Region: GLF; pfam03275 712961004576 Core-2/I-Branching enzyme; Region: Branch; pfam02485 712961004577 Bacterial sugar transferase; Region: Bac_transf; pfam02397 712961004578 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 712961004579 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 712961004580 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 712961004581 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 712961004582 Chain length determinant protein; Region: Wzz; cl15801 712961004583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 712961004584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 712961004585 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 712961004586 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961004587 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 712961004588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961004589 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 712961004590 putative ADP-binding pocket [chemical binding]; other site 712961004591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712961004592 active site 712961004593 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 712961004594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712961004595 putative ADP-binding pocket [chemical binding]; other site 712961004596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961004597 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961004598 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 712961004599 Part of AAA domain; Region: AAA_19; pfam13245 712961004600 Family description; Region: UvrD_C_2; pfam13538 712961004601 AAA domain; Region: AAA_21; pfam13304 712961004602 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 712961004603 putative active site [active] 712961004604 putative metal-binding site [ion binding]; other site 712961004605 Predicted membrane protein [Function unknown]; Region: COG4640 712961004606 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 712961004607 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 712961004608 Double zinc ribbon; Region: DZR; pfam12773 712961004609 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 712961004610 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 712961004611 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 712961004612 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 712961004613 NADP binding site [chemical binding]; other site 712961004614 active site 712961004615 putative substrate binding site [chemical binding]; other site 712961004616 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 712961004617 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 712961004618 NAD binding site [chemical binding]; other site 712961004619 substrate binding site [chemical binding]; other site 712961004620 homodimer interface [polypeptide binding]; other site 712961004621 active site 712961004622 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 712961004623 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 712961004624 substrate binding site; other site 712961004625 tetramer interface; other site 712961004626 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 712961004627 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 712961004628 active site 712961004629 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 712961004630 CAAX protease self-immunity; Region: Abi; pfam02517 712961004631 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 712961004632 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 712961004633 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 712961004634 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 712961004635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004636 motif II; other site 712961004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961004638 putative substrate translocation pore; other site 712961004639 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 712961004640 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712961004641 Zn2+ binding site [ion binding]; other site 712961004642 Mg2+ binding site [ion binding]; other site 712961004643 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 712961004644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 712961004645 Site-specific recombinase; Region: SpecificRecomb; cl15411 712961004646 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 712961004647 dimer interface [polypeptide binding]; other site 712961004648 substrate binding site [chemical binding]; other site 712961004649 ATP binding site [chemical binding]; other site 712961004650 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 712961004651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 712961004652 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961004653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004654 Walker A/P-loop; other site 712961004655 ATP binding site [chemical binding]; other site 712961004656 Q-loop/lid; other site 712961004657 ABC transporter signature motif; other site 712961004658 Walker B; other site 712961004659 D-loop; other site 712961004660 H-loop/switch region; other site 712961004661 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 712961004662 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 712961004663 metal binding site [ion binding]; metal-binding site 712961004664 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 712961004665 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 712961004666 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 712961004667 GTP-binding protein YchF; Reviewed; Region: PRK09601 712961004668 YchF GTPase; Region: YchF; cd01900 712961004669 G1 box; other site 712961004670 GTP/Mg2+ binding site [chemical binding]; other site 712961004671 Switch I region; other site 712961004672 G2 box; other site 712961004673 Switch II region; other site 712961004674 G3 box; other site 712961004675 G4 box; other site 712961004676 G5 box; other site 712961004677 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 712961004678 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 712961004679 ParB-like nuclease domain; Region: ParBc; pfam02195 712961004680 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 712961004681 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 712961004682 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961004683 P-loop; other site 712961004684 Magnesium ion binding site [ion binding]; other site 712961004685 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 712961004686 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 712961004687 ParB-like nuclease domain; Region: ParBc; pfam02195 712961004688 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 712961004689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712961004690 S-adenosylmethionine binding site [chemical binding]; other site 712961004691 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712961004692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712961004693 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 712961004694 NAD binding site [chemical binding]; other site 712961004695 dimer interface [polypeptide binding]; other site 712961004696 substrate binding site [chemical binding]; other site 712961004697 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 712961004698 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 712961004699 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 712961004700 putative active site [active] 712961004701 catalytic site [active] 712961004702 putative metal binding site [ion binding]; other site 712961004703 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 712961004704 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 712961004705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961004706 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 712961004707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004708 motif II; other site 712961004709 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 712961004710 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 712961004711 DJ-1 family protein; Region: not_thiJ; TIGR01383 712961004712 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 712961004713 conserved cys residue [active] 712961004714 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 712961004715 active site 712961004716 catalytic site [active] 712961004717 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 712961004718 Part of AAA domain; Region: AAA_19; pfam13245 712961004719 Family description; Region: UvrD_C_2; pfam13538 712961004720 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 712961004721 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 712961004722 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 712961004723 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 712961004724 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 712961004725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712961004726 active site 712961004727 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 712961004728 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 712961004729 putative catalytic cysteine [active] 712961004730 gamma-glutamyl kinase; Provisional; Region: PRK05429 712961004731 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 712961004732 nucleotide binding site [chemical binding]; other site 712961004733 homotetrameric interface [polypeptide binding]; other site 712961004734 putative phosphate binding site [ion binding]; other site 712961004735 putative allosteric binding site; other site 712961004736 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 712961004737 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 712961004738 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712961004739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004740 Walker A/P-loop; other site 712961004741 ATP binding site [chemical binding]; other site 712961004742 Q-loop/lid; other site 712961004743 ABC transporter signature motif; other site 712961004744 Walker B; other site 712961004745 D-loop; other site 712961004746 H-loop/switch region; other site 712961004747 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 712961004748 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 712961004749 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 712961004750 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 712961004751 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 712961004752 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 712961004753 active site 712961004754 P-loop; other site 712961004755 phosphorylation site [posttranslational modification] 712961004756 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 712961004757 active site 712961004758 P-loop; other site 712961004759 phosphorylation site [posttranslational modification] 712961004760 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 712961004761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712961004762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712961004763 substrate binding pocket [chemical binding]; other site 712961004764 membrane-bound complex binding site; other site 712961004765 hinge residues; other site 712961004766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961004767 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961004768 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712961004769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004770 Walker A/P-loop; other site 712961004771 ATP binding site [chemical binding]; other site 712961004772 Q-loop/lid; other site 712961004773 ABC transporter signature motif; other site 712961004774 Walker B; other site 712961004775 D-loop; other site 712961004776 H-loop/switch region; other site 712961004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004778 putative PBP binding loops; other site 712961004779 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 712961004780 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 712961004781 glutaminase active site [active] 712961004782 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 712961004783 dimer interface [polypeptide binding]; other site 712961004784 active site 712961004785 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 712961004786 dimer interface [polypeptide binding]; other site 712961004787 active site 712961004788 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 712961004789 HTH domain; Region: HTH_11; pfam08279 712961004790 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 712961004791 active site 712961004792 P-loop; other site 712961004793 phosphorylation site [posttranslational modification] 712961004794 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 712961004795 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 712961004796 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 712961004797 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 712961004798 amphipathic channel; other site 712961004799 Asn-Pro-Ala signature motifs; other site 712961004800 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 712961004801 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 712961004802 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 712961004803 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 712961004804 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 712961004805 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 712961004806 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 712961004807 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 712961004808 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 712961004809 potential frameshift: common BLAST hit: gi|90962608|ref|YP_536524.1| zinc-transporting ATPase 712961004810 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 712961004811 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961004812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 712961004813 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961004814 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 712961004815 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 712961004816 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 712961004817 Substrate-binding site [chemical binding]; other site 712961004818 Substrate specificity [chemical binding]; other site 712961004819 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 712961004820 AzlC protein; Region: AzlC; cl00570 712961004821 Transcriptional regulators [Transcription]; Region: MarR; COG1846 712961004822 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 712961004823 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 712961004824 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 712961004825 G-X-X-G motif; other site 712961004826 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 712961004827 RxxxH motif; other site 712961004828 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 712961004829 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961004830 Int/Topo IB signature motif; other site 712961004831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712961004832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961004833 non-specific DNA binding site [nucleotide binding]; other site 712961004834 salt bridge; other site 712961004835 sequence-specific DNA binding site [nucleotide binding]; other site 712961004836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961004837 non-specific DNA binding site [nucleotide binding]; other site 712961004838 salt bridge; other site 712961004839 sequence-specific DNA binding site [nucleotide binding]; other site 712961004840 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 712961004841 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 712961004842 nucleotide binding site [chemical binding]; other site 712961004843 polymerase nucleotide-binding site; other site 712961004844 primase nucleotide-binding site [nucleotide binding]; other site 712961004845 DNA-binding residues [nucleotide binding]; DNA binding site 712961004846 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 712961004847 D5 N terminal like; Region: D5_N; smart00885 712961004848 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 712961004849 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 712961004850 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 712961004851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961004852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961004853 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 712961004854 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 712961004855 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 712961004856 active site 712961004857 Zn binding site [ion binding]; other site 712961004858 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 712961004859 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 712961004860 homodimer interface [polypeptide binding]; other site 712961004861 substrate-cofactor binding pocket; other site 712961004862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961004863 catalytic residue [active] 712961004864 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 712961004865 SdpI/YhfL protein family; Region: SdpI; pfam13630 712961004866 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 712961004867 substrate binding site [chemical binding]; other site 712961004868 ATP binding site [chemical binding]; other site 712961004869 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 712961004870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 712961004871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 712961004872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712961004873 FtsX-like permease family; Region: FtsX; pfam02687 712961004874 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 712961004875 FtsX-like permease family; Region: FtsX; pfam02687 712961004876 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712961004877 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 712961004878 Walker A/P-loop; other site 712961004879 ATP binding site [chemical binding]; other site 712961004880 Q-loop/lid; other site 712961004881 ABC transporter signature motif; other site 712961004882 Walker B; other site 712961004883 D-loop; other site 712961004884 H-loop/switch region; other site 712961004885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961004886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961004887 AAA domain; Region: AAA_27; pfam13514 712961004888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 712961004889 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 712961004890 active site 712961004891 metal binding site [ion binding]; metal-binding site 712961004892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961004893 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961004894 active site 712961004895 catalytic tetrad [active] 712961004896 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 712961004897 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 712961004898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961004899 Walker A/P-loop; other site 712961004900 ATP binding site [chemical binding]; other site 712961004901 Q-loop/lid; other site 712961004902 ABC transporter signature motif; other site 712961004903 Walker B; other site 712961004904 D-loop; other site 712961004905 H-loop/switch region; other site 712961004906 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 712961004907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961004908 putative substrate translocation pore; other site 712961004909 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 712961004910 dimer interface [polypeptide binding]; other site 712961004911 catalytic triad [active] 712961004912 peroxidatic and resolving cysteines [active] 712961004913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 712961004914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 712961004915 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 712961004916 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 712961004917 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 712961004918 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 712961004919 S-methylmethionine transporter; Provisional; Region: PRK11387 712961004920 Spore germination protein; Region: Spore_permease; cl17796 712961004921 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 712961004922 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 712961004923 Walker A/P-loop; other site 712961004924 ATP binding site [chemical binding]; other site 712961004925 Q-loop/lid; other site 712961004926 ABC transporter signature motif; other site 712961004927 Walker B; other site 712961004928 D-loop; other site 712961004929 H-loop/switch region; other site 712961004930 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 712961004931 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 712961004932 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 712961004933 Walker A/P-loop; other site 712961004934 ATP binding site [chemical binding]; other site 712961004935 Q-loop/lid; other site 712961004936 ABC transporter signature motif; other site 712961004937 Walker B; other site 712961004938 D-loop; other site 712961004939 H-loop/switch region; other site 712961004940 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 712961004941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 712961004942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004943 dimer interface [polypeptide binding]; other site 712961004944 conserved gate region; other site 712961004945 putative PBP binding loops; other site 712961004946 ABC-ATPase subunit interface; other site 712961004947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 712961004948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712961004949 dimer interface [polypeptide binding]; other site 712961004950 conserved gate region; other site 712961004951 putative PBP binding loops; other site 712961004952 ABC-ATPase subunit interface; other site 712961004953 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 712961004954 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 712961004955 peptide binding site [polypeptide binding]; other site 712961004956 putative transport protein YifK; Provisional; Region: PRK10746 712961004957 elongation factor P; Validated; Region: PRK00529 712961004958 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 712961004959 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 712961004960 RNA binding site [nucleotide binding]; other site 712961004961 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 712961004962 RNA binding site [nucleotide binding]; other site 712961004963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004964 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712961004965 active site 712961004966 motif I; other site 712961004967 motif II; other site 712961004968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712961004969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712961004970 catalytic core [active] 712961004971 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 712961004972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961004973 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712961004974 glycerate kinase; Region: TIGR00045 712961004975 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 712961004976 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 712961004977 potential catalytic triad [active] 712961004978 conserved cys residue [active] 712961004979 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 712961004980 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 712961004981 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 712961004982 putative active site [active] 712961004983 catalytic site [active] 712961004984 putative metal binding site [ion binding]; other site 712961004985 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712961004986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712961004987 DNA binding site [nucleotide binding] 712961004988 domain linker motif; other site 712961004989 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 712961004990 dimerization interface [polypeptide binding]; other site 712961004991 ligand binding site [chemical binding]; other site 712961004992 sodium binding site [ion binding]; other site 712961004993 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 712961004994 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 712961004995 Ca binding site [ion binding]; other site 712961004996 active site 712961004997 catalytic site [active] 712961004998 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 712961004999 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 712961005000 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 712961005001 active site 712961005002 phosphorylation site [posttranslational modification] 712961005003 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 712961005004 conserved cys residue [active] 712961005005 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 712961005006 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 712961005007 dimer interface [polypeptide binding]; other site 712961005008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961005009 catalytic residue [active] 712961005010 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 712961005011 peptide binding site [polypeptide binding]; other site 712961005012 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 712961005013 dimer interface [polypeptide binding]; other site 712961005014 FMN binding site [chemical binding]; other site 712961005015 hypothetical protein; Validated; Region: PRK02101 712961005016 CAAX protease self-immunity; Region: Abi; pfam02517 712961005017 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 712961005018 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 712961005019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712961005020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712961005021 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 712961005022 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 712961005023 GDP-binding site [chemical binding]; other site 712961005024 ACT binding site; other site 712961005025 IMP binding site; other site 712961005026 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 712961005027 replicative DNA helicase; Provisional; Region: PRK05748 712961005028 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 712961005029 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 712961005030 Walker A motif; other site 712961005031 ATP binding site [chemical binding]; other site 712961005032 Walker B motif; other site 712961005033 DNA binding loops [nucleotide binding] 712961005034 potential frameshift: common BLAST hit: gi|90962697|ref|YP_536613.1| phosphoesterase, DHH family protein 712961005035 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 712961005036 DHH family; Region: DHH; pfam01368 712961005037 DHHA1 domain; Region: DHHA1; pfam02272 712961005038 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 712961005039 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 712961005040 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 712961005041 putative active site [active] 712961005042 putative metal binding site [ion binding]; other site 712961005043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961005044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961005045 LysR substrate binding domain; Region: LysR_substrate; pfam03466 712961005046 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 712961005047 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 712961005048 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 712961005049 Nucleoside recognition; Region: Gate; pfam07670 712961005050 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 712961005051 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 712961005052 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 712961005053 Initiator Replication protein; Region: Rep_3; pfam01051 712961005054 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 712961005055 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 712961005056 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 712961005057 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 712961005058 HPr interaction site; other site 712961005059 glycerol kinase (GK) interaction site [polypeptide binding]; other site 712961005060 active site 712961005061 phosphorylation site [posttranslational modification] 712961005062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 712961005063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961005064 P-loop; other site 712961005065 Magnesium ion binding site [ion binding]; other site 712961005066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 712961005067 Magnesium ion binding site [ion binding]; other site 712961005068 Probable transposase; Region: OrfB_IS605; pfam01385 712961005069 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712961005070 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 712961005071 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 712961005072 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 712961005073 Zn binding site [ion binding]; other site 712961005074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712961005075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712961005076 active site 712961005077 catalytic tetrad [active] 712961005078 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 712961005079 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 712961005080 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 712961005081 catalytic Zn binding site [ion binding]; other site 712961005082 NAD binding site [chemical binding]; other site 712961005083 structural Zn binding site [ion binding]; other site 712961005084 Predicted membrane protein [Function unknown]; Region: COG2364 712961005085 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 712961005086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 712961005087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 712961005088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961005089 putative substrate translocation pore; other site 712961005090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961005091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961005092 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 712961005093 N- and C-terminal domain interface [polypeptide binding]; other site 712961005094 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 712961005095 active site 712961005096 putative catalytic site [active] 712961005097 metal binding site [ion binding]; metal-binding site 712961005098 ATP binding site [chemical binding]; other site 712961005099 carbohydrate binding site [chemical binding]; other site 712961005100 L-rhamnose isomerase; Provisional; Region: PRK01076 712961005101 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 712961005102 intersubunit interface [polypeptide binding]; other site 712961005103 active site 712961005104 Zn2+ binding site [ion binding]; other site 712961005105 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961005106 Int/Topo IB signature motif; other site 712961005107 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961005108 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 712961005109 Methyltransferase domain; Region: Methyltransf_26; pfam13659 712961005110 potential frameshift: common BLAST hit: gi|268318802|ref|YP_003292458.1| type III restriction-modification system: adenine specific DNA 712961005111 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 712961005112 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 712961005113 DNA methylase; Region: N6_N4_Mtase; pfam01555 712961005114 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 712961005115 DNA methylase; Region: N6_N4_Mtase; pfam01555 712961005116 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 712961005117 DNA methylase; Region: N6_N4_Mtase; pfam01555 712961005118 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 712961005119 DNA methylase; Region: N6_N4_Mtase; pfam01555 712961005120 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 712961005121 DNA methylase; Region: N6_N4_Mtase; pfam01555 712961005122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712961005123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 712961005124 ATP binding site [chemical binding]; other site 712961005125 putative Mg++ binding site [ion binding]; other site 712961005126 stage V sporulation protein K; Region: spore_V_K; TIGR02881 712961005127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961005128 Walker A motif; other site 712961005129 ATP binding site [chemical binding]; other site 712961005130 Walker B motif; other site 712961005131 arginine finger; other site 712961005132 stage V sporulation protein K; Region: spore_V_K; TIGR02881 712961005133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961005134 Walker A motif; other site 712961005135 ATP binding site [chemical binding]; other site 712961005136 Walker B motif; other site 712961005137 arginine finger; other site 712961005138 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 712961005139 amino acid transporter; Region: 2A0306; TIGR00909 712961005140 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712961005141 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 712961005142 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262 712961005143 NAD binding site [chemical binding]; other site 712961005144 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 712961005145 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 712961005146 EDD domain protein, DegV family; Region: DegV; TIGR00762 712961005147 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712961005148 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 712961005149 potential frameshift: common BLAST hit: gi|336053354|ref|YP_004558046.1| cell-envelope associated proteinase 712961005150 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 712961005151 putative active site [active] 712961005152 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 712961005153 potential frameshift: common BLAST hit: gi|336053354|ref|YP_004558046.1| cell-envelope associated proteinase 712961005154 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 712961005155 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 712961005156 FAD binding pocket [chemical binding]; other site 712961005157 conserved FAD binding motif [chemical binding]; other site 712961005158 phosphate binding motif [ion binding]; other site 712961005159 beta-alpha-beta structure motif; other site 712961005160 NAD binding pocket [chemical binding]; other site 712961005161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712961005162 Probable transposase; Region: OrfB_IS605; pfam01385 712961005163 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712961005164 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 712961005165 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 712961005166 dimerization interface [polypeptide binding]; other site 712961005167 DPS ferroxidase diiron center [ion binding]; other site 712961005168 ion pore; other site 712961005169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 712961005170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 712961005171 ligand binding site [chemical binding]; other site 712961005172 flexible hinge region; other site 712961005173 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 712961005174 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712961005175 Soluble P-type ATPase [General function prediction only]; Region: COG4087 712961005176 putative transposase OrfB; Reviewed; Region: PHA02517 712961005177 HTH-like domain; Region: HTH_21; pfam13276 712961005178 Integrase core domain; Region: rve; pfam00665 712961005179 Integrase core domain; Region: rve_3; pfam13683 712961005180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961005181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961005182 putative substrate translocation pore; other site 712961005183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961005184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712961005185 putative substrate translocation pore; other site 712961005186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712961005187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712961005188 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 712961005189 putative dimerization interface [polypeptide binding]; other site 712961005190 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 712961005191 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 712961005192 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 712961005193 classical (c) SDRs; Region: SDR_c; cd05233 712961005194 NAD(P) binding site [chemical binding]; other site 712961005195 active site 712961005196 FMN-binding domain; Region: FMN_bind; pfam04205 712961005197 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 712961005198 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 712961005199 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 712961005200 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 712961005201 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 712961005202 shikimate binding site; other site 712961005203 NAD(P) binding site [chemical binding]; other site 712961005204 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 712961005205 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 712961005206 active site 712961005207 catalytic residue [active] 712961005208 dimer interface [polypeptide binding]; other site 712961005209 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 712961005210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712961005211 active site 712961005212 DNA binding site [nucleotide binding] 712961005213 Int/Topo IB signature motif; other site 712961005214 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 712961005215 active site 712961005216 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 712961005217 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 712961005218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 712961005219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961005220 active site 712961005221 phosphorylation site [posttranslational modification] 712961005222 intermolecular recognition site; other site 712961005223 dimerization interface [polypeptide binding]; other site 712961005224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 712961005225 DNA binding residues [nucleotide binding] 712961005226 dimerization interface [polypeptide binding]; other site 712961005227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 712961005228 Histidine kinase; Region: HisKA_3; pfam07730 712961005229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712961005230 ATP binding site [chemical binding]; other site 712961005231 Mg2+ binding site [ion binding]; other site 712961005232 G-X-G motif; other site 712961005233 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 712961005234 ABC-2 type transporter; Region: ABC2_membrane; cl17235 712961005235 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712961005236 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 712961005237 Walker A/P-loop; other site 712961005238 ATP binding site [chemical binding]; other site 712961005239 Q-loop/lid; other site 712961005240 ABC transporter signature motif; other site 712961005241 Walker B; other site 712961005242 D-loop; other site 712961005243 H-loop/switch region; other site 712961005244 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 712961005245 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712961005246 active site 712961005247 dimer interface [polypeptide binding]; other site 712961005248 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 712961005249 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 712961005250 substrate binding site [chemical binding]; other site 712961005251 hexamer interface [polypeptide binding]; other site 712961005252 metal binding site [ion binding]; metal-binding site 712961005253 potential frameshift: common BLAST hit: gi|90962617|ref|YP_536533.1| phage integrase 712961005254 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961005255 Int/Topo IB signature motif; other site 712961005256 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712961005257 CHAP domain; Region: CHAP; cl17642 712961005258 AAA-like domain; Region: AAA_10; pfam12846 712961005259 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 712961005260 Walker A motif; other site 712961005261 ATP binding site [chemical binding]; other site 712961005262 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 712961005263 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 712961005264 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 712961005265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961005266 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 712961005267 Walker A motif; other site 712961005268 ATP binding site [chemical binding]; other site 712961005269 Walker B motif; other site 712961005270 arginine finger; other site 712961005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712961005272 Walker A motif; other site 712961005273 ATP binding site [chemical binding]; other site 712961005274 Walker B motif; other site 712961005275 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 712961005276 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 712961005277 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 712961005278 active site 712961005279 putative interdomain interaction site [polypeptide binding]; other site 712961005280 putative metal-binding site [ion binding]; other site 712961005281 putative nucleotide binding site [chemical binding]; other site 712961005282 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 712961005283 domain I; other site 712961005284 DNA binding groove [nucleotide binding] 712961005285 phosphate binding site [ion binding]; other site 712961005286 domain II; other site 712961005287 domain III; other site 712961005288 nucleotide binding site [chemical binding]; other site 712961005289 catalytic site [active] 712961005290 domain IV; other site 712961005291 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 712961005292 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 712961005293 active site 712961005294 metal binding site [ion binding]; metal-binding site 712961005295 interdomain interaction site; other site 712961005296 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961005297 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 712961005298 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 712961005299 Glucan-binding protein C; Region: GbpC; pfam08363 712961005300 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 712961005301 Glucan-binding protein C; Region: GbpC; pfam08363 712961005302 Putative uncharacterized protein (Fragment); HN6_01602 712961005303 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712961005304 Int/Topo IB signature motif; other site 712961005305 Fic family protein [Function unknown]; Region: COG3177 712961005306 Fic/DOC family; Region: Fic; pfam02661 712961005307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961005308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712961005309 non-specific DNA binding site [nucleotide binding]; other site 712961005310 salt bridge; other site 712961005311 sequence-specific DNA binding site [nucleotide binding]; other site 712961005312 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 712961005313 K+ potassium transporter; Region: K_trans; cl15781 712961005314 hypothetical protein; Provisional; Region: PRK11281 712961005315 Fic/DOC family; Region: Fic; pfam02661 712961005316 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 712961005317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712961005318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712961005319 non-specific DNA binding site [nucleotide binding]; other site 712961005320 salt bridge; other site 712961005321 sequence-specific DNA binding site [nucleotide binding]; other site 712961005322 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 712961005323 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 712961005324 catalytic residues [active] 712961005325 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 712961005326 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 712961005327 Fic/DOC family; Region: Fic; cl00960 712961005328 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 712961005329 Mg binding site [ion binding]; other site 712961005330 nucleotide binding site [chemical binding]; other site 712961005331 putative protofilament interface [polypeptide binding]; other site 712961005332 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 712961005333 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 712961005334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 712961005335 FeS/SAM binding site; other site 712961005336 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 712961005337 Pyruvate formate lyase 1; Region: PFL1; cd01678 712961005338 coenzyme A binding site [chemical binding]; other site 712961005339 active site 712961005340 catalytic residues [active] 712961005341 glycine loop; other site 712961005342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712961005343 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712961005344 CCC1-related family of proteins; Region: CCC1_like; cl00278 712961005345 Similar to transposase IS1272 (Fragment); HN6_01626 712961005346 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 712961005347 FeS assembly protein SufB; Region: sufB; TIGR01980 712961005348 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 712961005349 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 712961005350 trimerization site [polypeptide binding]; other site 712961005351 active site 712961005352 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 712961005353 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 712961005354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712961005355 catalytic residue [active] 712961005356 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 712961005357 FeS assembly protein SufD; Region: sufD; TIGR01981 712961005358 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 712961005359 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 712961005360 Walker A/P-loop; other site 712961005361 ATP binding site [chemical binding]; other site 712961005362 Q-loop/lid; other site 712961005363 ABC transporter signature motif; other site 712961005364 Walker B; other site 712961005365 D-loop; other site 712961005366 H-loop/switch region; other site 712961005367 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 712961005368 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 712961005369 peptide binding site [polypeptide binding]; other site 712961005370 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 712961005371 Cl- selectivity filter; other site 712961005372 Cl- binding residues [ion binding]; other site 712961005373 pore gating glutamate residue; other site 712961005374 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 712961005375 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 712961005376 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 712961005377 D-lactate dehydrogenase; Validated; Region: PRK08605 712961005378 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 712961005379 homodimer interface [polypeptide binding]; other site 712961005380 ligand binding site [chemical binding]; other site 712961005381 NAD binding site [chemical binding]; other site 712961005382 catalytic site [active] 712961005383 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 712961005384 active site 712961005385 intersubunit interactions; other site 712961005386 catalytic residue [active] 712961005387 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 712961005388 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 712961005389 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 712961005390 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 712961005391 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 712961005392 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 712961005393 HTH domain; Region: HTH_11; pfam08279 712961005394 PRD domain; Region: PRD; pfam00874 712961005395 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 712961005396 active site 712961005397 phosphorylation site [posttranslational modification] 712961005398 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 712961005399 classical (c) SDRs; Region: SDR_c; cd05233 712961005400 NAD(P) binding site [chemical binding]; other site 712961005401 active site 712961005402 Phage-related tail protein [Function unknown]; Region: COG5283 712961005403 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 712961005404 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 712961005405 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 712961005406 FMN binding site [chemical binding]; other site 712961005407 substrate binding site [chemical binding]; other site 712961005408 putative catalytic residue [active] 712961005409 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 712961005410 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 712961005411 putative catalytic cysteine [active] 712961005412 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 712961005413 putative active site [active] 712961005414 metal binding site [ion binding]; metal-binding site 712961005415 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 712961005416 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 712961005417 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 712961005418 HlyD family secretion protein; Region: HlyD_3; pfam13437 712961005419 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 712961005420 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 712961005421 putative active site [active] 712961005422 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712961005423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712961005424 Walker A/P-loop; other site 712961005425 ATP binding site [chemical binding]; other site 712961005426 Q-loop/lid; other site 712961005427 ABC transporter signature motif; other site 712961005428 Walker B; other site 712961005429 D-loop; other site 712961005430 H-loop/switch region; other site 712961005431 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 712961005432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712961005433 active site 712961005434 phosphorylation site [posttranslational modification] 712961005435 intermolecular recognition site; other site 712961005436 dimerization interface [polypeptide binding]; other site 712961005437 LytTr DNA-binding domain; Region: LytTR; pfam04397 712961005438 potential frameshift: common BLAST hit: gi|90962885|ref|YP_536800.1| AbpK sensory transduction histidine kinase 712961005439 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 712961005440 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 712961005441 catalytic residues [active] 712961005442 transaminase; Reviewed; Region: PRK08068 712961005443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712961005444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712961005445 homodimer interface [polypeptide binding]; other site 712961005446 catalytic residue [active] 712961005447 Predicted amidohydrolase [General function prediction only]; Region: COG0388 712961005448 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 712961005449 putative active site [active] 712961005450 catalytic triad [active] 712961005451 putative dimer interface [polypeptide binding]; other site 712961005452 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 712961005453 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 712961005454 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 712961005455 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 712961005456 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 712961005457 MFS/sugar transport protein; Region: MFS_2; pfam13347 712961005458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712961005459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 712961005460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 712961005461 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 712961005462 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 712961005463 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712961005464 nucleotide binding site [chemical binding]; other site 712961005465 Class I aldolases; Region: Aldolase_Class_I; cl17187 712961005466 catalytic residue [active] 712961005467 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 712961005468 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 712961005469 putative active site cavity [active] 712961005470 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 712961005471 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 712961005472 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 712961005473 putative active site [active] 712961005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712961005475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 712961005476 NAD(P) binding site [chemical binding]; other site 712961005477 active site 712961005478 inner membrane transporter YjeM; Provisional; Region: PRK15238 712961005479 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 712961005480 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 712961005481 G1 box; other site 712961005482 putative GEF interaction site [polypeptide binding]; other site 712961005483 GTP/Mg2+ binding site [chemical binding]; other site 712961005484 Switch I region; other site 712961005485 G2 box; other site 712961005486 G3 box; other site 712961005487 Switch II region; other site 712961005488 G4 box; other site 712961005489 G5 box; other site 712961005490 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 712961005491 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 712961005492 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 712961005493 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 712961005494 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 712961005495 TPP-binding site [chemical binding]; other site 712961005496 dimer interface [polypeptide binding]; other site 712961005497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 712961005498 PYR/PP interface [polypeptide binding]; other site 712961005499 dimer interface [polypeptide binding]; other site 712961005500 TPP binding site [chemical binding]; other site 712961005501 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 712961005502 active site 712961005503 intersubunit interactions; other site 712961005504 catalytic residue [active] 712961005505 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 712961005506 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 712961005507 substrate binding site [chemical binding]; other site 712961005508 hexamer interface [polypeptide binding]; other site 712961005509 metal binding site [ion binding]; metal-binding site 712961005510 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 712961005511 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 712961005512 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 712961005513 active site 712961005514 phosphorylation site [posttranslational modification] 712961005515 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 712961005516 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 712961005517 putative NAD(P) binding site [chemical binding]; other site 712961005518 putative catalytic Zn binding site [ion binding]; other site 712961005519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 712961005520 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 712961005521 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 712961005522 putative phosphoketolase; Provisional; Region: PRK05261 712961005523 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 712961005524 TPP-binding site; other site 712961005525 XFP C-terminal domain; Region: XFP_C; pfam09363 712961005526 HTH-like domain; Region: HTH_21; pfam13276 712961005527 Integrase core domain; Region: rve; pfam00665