-- dump date 20140619_125037 -- class Genbank::misc_feature -- table misc_feature_note -- id note 362948000001 MobA/MobL family; Region: MobA_MobL; pfam03389 362948000002 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 362948000003 Fic family protein [Function unknown]; Region: COG3177 362948000004 Fic/DOC family; Region: Fic; pfam02661 362948000005 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 362948000006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 362948000007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 362948000008 P-loop; other site 362948000009 Magnesium ion binding site [ion binding]; other site 362948000010 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 362948000011 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 362948000012 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 362948000013 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 362948000014 catalytic residues [active] 362948000015 catalytic nucleophile [active] 362948000016 Presynaptic Site I dimer interface [polypeptide binding]; other site 362948000017 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 362948000018 Synaptic Flat tetramer interface [polypeptide binding]; other site 362948000019 Synaptic Site I dimer interface [polypeptide binding]; other site 362948000020 DNA binding site [nucleotide binding] 362948000021 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 362948000022 DNA-binding interface [nucleotide binding]; DNA binding site 362948000023 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 362948000024 TrkA-N domain; Region: TrkA_N; pfam02254 362948000025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948000026 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948000027 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 362948000028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 362948000029 Predicted membrane protein [Function unknown]; Region: COG2261 362948000030 CsbD-like; Region: CsbD; cl17424 362948000031 Helix-turn-helix domain; Region: HTH_28; pfam13518 362948000032 putative transposase OrfB; Reviewed; Region: PHA02517 362948000033 HTH-like domain; Region: HTH_21; pfam13276 362948000034 Integrase core domain; Region: rve; pfam00665 362948000035 Integrase core domain; Region: rve_3; pfam13683 362948000036 Y-family of DNA polymerases; Region: PolY; cl12025 362948000037 active site 362948000038 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362948000039 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 362948000040 PemK-like protein; Region: PemK; pfam02452 362948000041 Transposase, Mutator family; Region: Transposase_mut; cl19537 362948000042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 362948000043 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 362948000044 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 362948000045 active site 362948000046 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 362948000047 nudix motif; other site 362948000048 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 362948000049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948000050 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 362948000051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 362948000052 active site 362948000053 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 362948000054 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 362948000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 362948000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 362948000057 RelB antitoxin; Region: RelB; cl01171 362948000058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 362948000059 VirC1 protein; Region: VirC1; cl17401 362948000060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 362948000061 P-loop; other site 362948000062 Magnesium ion binding site [ion binding]; other site 362948000063 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 362948000064 Fic family protein [Function unknown]; Region: COG3177 362948000065 Fic/DOC family; Region: Fic; pfam02661 362948000066 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 362948000067 MobA/MobL family; Region: MobA_MobL; pfam03389 362948000068 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 362948000069 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 362948000070 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 362948000071 putative NAD(P) binding site [chemical binding]; other site 362948000072 dimer interface [polypeptide binding]; other site 362948000073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 362948000074 Transposase, Mutator family; Region: Transposase_mut; cl19537 362948000075 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362948000076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000077 Walker A/P-loop; other site 362948000078 ATP binding site [chemical binding]; other site 362948000079 Q-loop/lid; other site 362948000080 ABC transporter signature motif; other site 362948000081 Walker B; other site 362948000082 D-loop; other site 362948000083 H-loop/switch region; other site 362948000084 ABC-2 type transporter; Region: ABC2_membrane; cl17235 362948000085 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362948000086 LytTr DNA-binding domain; Region: LytTR; smart00850 362948000087 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 362948000088 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 362948000089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948000091 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948000092 similar to putative collagen binding protein Cbn 362948000093 Cobalt transport protein; Region: CbiQ; cl00463 362948000094 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 362948000095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362948000096 Walker A/P-loop; other site 362948000097 ATP binding site [chemical binding]; other site 362948000098 Q-loop/lid; other site 362948000099 ABC transporter signature motif; other site 362948000100 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 362948000101 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362948000102 Walker A/P-loop; other site 362948000103 ATP binding site [chemical binding]; other site 362948000104 Q-loop/lid; other site 362948000105 ABC transporter signature motif; other site 362948000106 Walker B; other site 362948000107 D-loop; other site 362948000108 H-loop/switch region; other site 362948000109 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 362948000110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000111 dimer interface [polypeptide binding]; other site 362948000112 conserved gate region; other site 362948000113 putative PBP binding loops; other site 362948000114 ABC-ATPase subunit interface; other site 362948000115 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 362948000116 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 362948000117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000118 Walker A/P-loop; other site 362948000119 ATP binding site [chemical binding]; other site 362948000120 Q-loop/lid; other site 362948000121 ABC transporter signature motif; other site 362948000122 Walker B; other site 362948000123 D-loop; other site 362948000124 H-loop/switch region; other site 362948000125 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 362948000126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948000128 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948000129 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 362948000130 multiple promoter invertase; Provisional; Region: mpi; PRK13413 362948000131 catalytic residues [active] 362948000132 catalytic nucleophile [active] 362948000133 Presynaptic Site I dimer interface [polypeptide binding]; other site 362948000134 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 362948000135 Synaptic Flat tetramer interface [polypeptide binding]; other site 362948000136 Synaptic Site I dimer interface [polypeptide binding]; other site 362948000137 DNA binding site [nucleotide binding] 362948000138 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 362948000139 RelB antitoxin; Region: RelB; cl01171 362948000140 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 362948000141 UNKNOWN FEATURE KEY Comment; Source DNA is available from Eva McArdle at Alimentary Pharmabiotic Centre (e.mcardle@ucc.ie) 362948000142 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 362948000143 DnaA N-terminal domain; Region: DnaA_N; pfam11638 362948000144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948000145 Walker A motif; other site 362948000146 ATP binding site [chemical binding]; other site 362948000147 Walker B motif; other site 362948000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 362948000149 arginine finger; other site 362948000150 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 362948000151 DnaA box-binding interface [nucleotide binding]; other site 362948000152 DNA polymerase III subunit beta; Validated; Region: PRK05643 362948000153 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 362948000154 putative DNA binding surface [nucleotide binding]; other site 362948000155 dimer interface [polypeptide binding]; other site 362948000156 beta-clamp/clamp loader binding surface; other site 362948000157 beta-clamp/translesion DNA polymerase binding surface; other site 362948000158 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 362948000159 recombination protein F; Reviewed; Region: recF; PRK00064 362948000160 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 362948000161 Walker A/P-loop; other site 362948000162 ATP binding site [chemical binding]; other site 362948000163 Q-loop/lid; other site 362948000164 ABC transporter signature motif; other site 362948000165 Walker B; other site 362948000166 D-loop; other site 362948000167 H-loop/switch region; other site 362948000168 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 362948000169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948000170 ATP binding site [chemical binding]; other site 362948000171 Mg2+ binding site [ion binding]; other site 362948000172 G-X-G motif; other site 362948000173 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 362948000174 anchoring element; other site 362948000175 dimer interface [polypeptide binding]; other site 362948000176 ATP binding site [chemical binding]; other site 362948000177 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 362948000178 active site 362948000179 putative metal-binding site [ion binding]; other site 362948000180 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 362948000181 DNA gyrase subunit A; Validated; Region: PRK05560 362948000182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 362948000183 CAP-like domain; other site 362948000184 active site 362948000185 primary dimer interface [polypeptide binding]; other site 362948000186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362948000192 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 362948000193 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 362948000194 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 362948000195 dimer interface [polypeptide binding]; other site 362948000196 ssDNA binding site [nucleotide binding]; other site 362948000197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362948000198 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 362948000199 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 362948000200 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 362948000201 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 362948000202 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362948000203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362948000204 active site 362948000205 Similar to peptidoglycan-specific endopeptidase, M23 family; nonfunctional due to truncation 362948000206 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 362948000207 active site 362948000208 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 362948000209 dimer interface [polypeptide binding]; other site 362948000210 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 362948000211 Ligand Binding Site [chemical binding]; other site 362948000212 Molecular Tunnel; other site 362948000213 Similar to hypothetical membrane spanning protein; nonfunctional due to frameshift 362948000214 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 362948000215 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 362948000216 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 362948000217 PYR/PP interface [polypeptide binding]; other site 362948000218 dimer interface [polypeptide binding]; other site 362948000219 tetramer interface [polypeptide binding]; other site 362948000220 TPP binding site [chemical binding]; other site 362948000221 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362948000222 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 362948000223 TPP-binding site [chemical binding]; other site 362948000224 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 362948000225 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 362948000226 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362948000227 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948000228 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362948000229 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 362948000230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948000231 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 362948000232 drug efflux system protein MdtG; Provisional; Region: PRK09874 362948000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948000234 putative substrate translocation pore; other site 362948000235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948000236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948000237 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 362948000238 Sugar transport protein; Region: Sugar_transport; cl19288 362948000239 Uncharacterized conserved protein [Function unknown]; Region: COG2966 362948000240 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 362948000241 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 362948000242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362948000243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948000244 Coenzyme A binding pocket [chemical binding]; other site 362948000245 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 362948000246 EamA-like transporter family; Region: EamA; pfam00892 362948000247 EamA-like transporter family; Region: EamA; pfam00892 362948000248 oligoendopeptidase F; Region: pepF; TIGR00181 362948000249 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 362948000250 active site 362948000251 Zn binding site [ion binding]; other site 362948000252 cysteine synthase; Region: PLN02565 362948000253 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 362948000254 dimer interface [polypeptide binding]; other site 362948000255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948000256 catalytic residue [active] 362948000257 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 362948000258 homodimer interface [polypeptide binding]; other site 362948000259 substrate-cofactor binding pocket; other site 362948000260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948000261 catalytic residue [active] 362948000262 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 362948000263 active site 362948000264 NAD binding site [chemical binding]; other site 362948000265 metal binding site [ion binding]; metal-binding site 362948000266 methionine sulfoxide reductase B; Provisional; Region: PRK00222 362948000267 RelB antitoxin; Region: RelB; cl01171 362948000268 Similar to hypothetical protein; nonfunctional due to frameshift and interrupting stop codon 362948000269 Similar to conserved hypothetical protein; nonfunctional due to frameshift 362948000270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948000271 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 362948000272 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362948000273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948000274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000275 Walker A/P-loop; other site 362948000276 ATP binding site [chemical binding]; other site 362948000277 Q-loop/lid; other site 362948000278 ABC transporter signature motif; other site 362948000279 Walker B; other site 362948000280 D-loop; other site 362948000281 H-loop/switch region; other site 362948000282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362948000283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948000284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000285 Walker A/P-loop; other site 362948000286 ATP binding site [chemical binding]; other site 362948000287 Q-loop/lid; other site 362948000288 ABC transporter signature motif; other site 362948000289 Walker B; other site 362948000290 D-loop; other site 362948000291 H-loop/switch region; other site 362948000292 sugar phosphate phosphatase; Provisional; Region: PRK10513 362948000293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948000294 active site 362948000295 motif I; other site 362948000296 motif II; other site 362948000297 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948000298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948000299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948000300 active site 362948000301 phosphorylation site [posttranslational modification] 362948000302 intermolecular recognition site; other site 362948000303 dimerization interface [polypeptide binding]; other site 362948000304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362948000305 DNA binding site [nucleotide binding] 362948000306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 362948000307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362948000308 dimerization interface [polypeptide binding]; other site 362948000309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362948000310 putative active site [active] 362948000311 heme pocket [chemical binding]; other site 362948000312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362948000313 dimer interface [polypeptide binding]; other site 362948000314 phosphorylation site [posttranslational modification] 362948000315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948000316 ATP binding site [chemical binding]; other site 362948000317 Mg2+ binding site [ion binding]; other site 362948000318 G-X-G motif; other site 362948000319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 362948000320 YycH protein; Region: YycH; pfam07435 362948000321 YycH protein; Region: YycI; pfam09648 362948000322 Similar to conserved hypothetical protein; nonfunctional due to frameshift 362948000323 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 362948000324 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 362948000325 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362948000326 protein binding site [polypeptide binding]; other site 362948000327 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 362948000328 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 362948000329 putative NAD(P) binding site [chemical binding]; other site 362948000330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 362948000331 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948000332 short chain dehydrogenase; Provisional; Region: PRK06180 362948000333 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 362948000334 NADP binding site [chemical binding]; other site 362948000335 active site 362948000336 steroid binding site; other site 362948000337 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 362948000338 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 362948000339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948000340 putative substrate translocation pore; other site 362948000341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948000342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948000343 Helix-turn-helix domain; Region: HTH_28; pfam13518 362948000344 Similar to transposase ISLasa2a, IS1223 family; nonfunctional due to frameshift 362948000345 Transposase IS200 like; Region: Y1_Tnp; pfam01797 362948000346 Similar to reverse transcriptase; nonfunctional due to interrupting stop codon 362948000347 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 362948000348 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 362948000349 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 362948000350 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948000351 ABC transporter; Region: ABC_tran_2; pfam12848 362948000352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948000353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948000354 salt bridge; other site 362948000355 sequence-specific DNA binding site [nucleotide binding]; other site 362948000356 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 362948000357 active site 362948000358 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 362948000359 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 362948000360 catalytic triad [active] 362948000361 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 362948000362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948000363 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 362948000364 Walker A motif; other site 362948000365 ATP binding site [chemical binding]; other site 362948000366 Walker B motif; other site 362948000367 arginine finger; other site 362948000368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948000369 Walker A motif; other site 362948000370 ATP binding site [chemical binding]; other site 362948000371 Walker B motif; other site 362948000372 arginine finger; other site 362948000373 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362948000374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362948000375 Ligand Binding Site [chemical binding]; other site 362948000376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948000377 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948000378 substrate binding pocket [chemical binding]; other site 362948000379 membrane-bound complex binding site; other site 362948000380 hinge residues; other site 362948000381 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000383 dimer interface [polypeptide binding]; other site 362948000384 conserved gate region; other site 362948000385 putative PBP binding loops; other site 362948000386 ABC-ATPase subunit interface; other site 362948000387 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 362948000388 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 362948000389 homodimer interface [polypeptide binding]; other site 362948000390 substrate-cofactor binding pocket; other site 362948000391 catalytic residue [active] 362948000392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362948000393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362948000394 DNA binding site [nucleotide binding] 362948000395 domain linker motif; other site 362948000396 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 362948000397 dimerization interface [polypeptide binding]; other site 362948000398 ligand binding site [chemical binding]; other site 362948000399 sodium binding site [ion binding]; other site 362948000400 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 362948000401 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 362948000402 substrate binding [chemical binding]; other site 362948000403 active site 362948000404 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 362948000405 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 362948000406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362948000407 active site turn [active] 362948000408 phosphorylation site [posttranslational modification] 362948000409 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362948000410 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 362948000411 HPr interaction site; other site 362948000412 glycerol kinase (GK) interaction site [polypeptide binding]; other site 362948000413 active site 362948000414 phosphorylation site [posttranslational modification] 362948000415 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 362948000416 homodimer interface [polypeptide binding]; other site 362948000417 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 362948000418 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 362948000419 active site 362948000420 catalytic site [active] 362948000421 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 362948000422 Cation transport protein; Region: TrkH; cl17365 362948000423 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 362948000424 TrkA-N domain; Region: TrkA_N; pfam02254 362948000425 TrkA-C domain; Region: TrkA_C; pfam02080 362948000426 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 362948000427 active site 362948000428 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362948000429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362948000430 active site 362948000431 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 362948000432 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 362948000433 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 362948000434 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 362948000435 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 362948000436 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362948000437 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362948000438 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362948000439 Similar to hydrolase (HAD superfamily); nonfunctional due to frameshift 362948000440 Similar to immunity protein PlnL; nonfunctional due to frameshift 362948000441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948000442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948000443 putative substrate translocation pore; other site 362948000444 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 362948000445 DNA binding residues [nucleotide binding] 362948000446 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 362948000447 putative dimer interface [polypeptide binding]; other site 362948000448 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 362948000449 putative metal binding site [ion binding]; other site 362948000450 Protein of unknown function (DUF554); Region: DUF554; pfam04474 362948000451 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 362948000452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 362948000453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362948000454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948000455 active site 362948000456 phosphorylation site [posttranslational modification] 362948000457 intermolecular recognition site; other site 362948000458 dimerization interface [polypeptide binding]; other site 362948000459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362948000460 DNA binding residues [nucleotide binding] 362948000461 dimerization interface [polypeptide binding]; other site 362948000462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 362948000463 Histidine kinase; Region: HisKA_3; pfam07730 362948000464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948000465 ATP binding site [chemical binding]; other site 362948000466 Mg2+ binding site [ion binding]; other site 362948000467 G-X-G motif; other site 362948000468 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 362948000469 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 362948000470 ligand binding site [chemical binding]; other site 362948000471 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 362948000472 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362948000473 active pocket/dimerization site; other site 362948000474 active site 362948000475 phosphorylation site [posttranslational modification] 362948000476 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362948000477 active site 362948000478 phosphorylation site [posttranslational modification] 362948000479 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 362948000480 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 362948000481 Domain of unknown function (DUF956); Region: DUF956; pfam06115 362948000482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948000483 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 362948000484 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948000485 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948000486 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 362948000487 NlpC/P60 family; Region: NLPC_P60; pfam00877 362948000488 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 362948000489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948000490 catalytic residue [active] 362948000491 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 362948000492 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 362948000493 putative ligand binding site [chemical binding]; other site 362948000494 putative NAD binding site [chemical binding]; other site 362948000495 putative catalytic site [active] 362948000496 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 362948000497 L-serine binding site [chemical binding]; other site 362948000498 ACT domain interface; other site 362948000499 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 362948000500 putative uracil binding site [chemical binding]; other site 362948000501 putative active site [active] 362948000502 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 362948000503 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 362948000504 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 362948000505 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 362948000506 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 362948000507 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 362948000508 tetramer interface [polypeptide binding]; other site 362948000509 putative DNA binding site [nucleotide binding]; other site 362948000510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 362948000511 Predicted membrane protein [Function unknown]; Region: COG4709 362948000512 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 362948000513 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 362948000514 PspC domain; Region: PspC; pfam04024 362948000515 Enterocin A Immunity; Region: EntA_Immun; pfam08951 362948000516 glycerol kinase; Provisional; Region: glpK; PRK00047 362948000517 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 362948000518 N- and C-terminal domain interface [polypeptide binding]; other site 362948000519 active site 362948000520 MgATP binding site [chemical binding]; other site 362948000521 catalytic site [active] 362948000522 metal binding site [ion binding]; metal-binding site 362948000523 glycerol binding site [chemical binding]; other site 362948000524 homotetramer interface [polypeptide binding]; other site 362948000525 homodimer interface [polypeptide binding]; other site 362948000526 FBP binding site [chemical binding]; other site 362948000527 protein IIAGlc interface [polypeptide binding]; other site 362948000528 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 362948000529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000530 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 362948000531 amphipathic channel; other site 362948000532 Asn-Pro-Ala signature motifs; other site 362948000533 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 362948000534 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 362948000535 Walker A/P-loop; other site 362948000536 ATP binding site [chemical binding]; other site 362948000537 Q-loop/lid; other site 362948000538 ABC transporter signature motif; other site 362948000539 Walker B; other site 362948000540 D-loop; other site 362948000541 H-loop/switch region; other site 362948000542 TOBE domain; Region: TOBE_2; pfam08402 362948000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000544 dimer interface [polypeptide binding]; other site 362948000545 conserved gate region; other site 362948000546 putative PBP binding loops; other site 362948000547 ABC-ATPase subunit interface; other site 362948000548 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 362948000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000550 dimer interface [polypeptide binding]; other site 362948000551 conserved gate region; other site 362948000552 putative PBP binding loops; other site 362948000553 ABC-ATPase subunit interface; other site 362948000554 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 362948000555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 362948000556 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 362948000557 zinc binding site [ion binding]; other site 362948000558 putative ligand binding site [chemical binding]; other site 362948000559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 362948000560 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 362948000561 TM-ABC transporter signature motif; other site 362948000562 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 362948000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000564 Walker A/P-loop; other site 362948000565 ATP binding site [chemical binding]; other site 362948000566 Q-loop/lid; other site 362948000567 ABC transporter signature motif; other site 362948000568 Walker B; other site 362948000569 D-loop; other site 362948000570 H-loop/switch region; other site 362948000571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 362948000572 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362948000573 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 362948000574 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 362948000575 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 362948000576 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 362948000577 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 362948000578 trmE is a tRNA modification GTPase; Region: trmE; cd04164 362948000579 G1 box; other site 362948000580 GTP/Mg2+ binding site [chemical binding]; other site 362948000581 Switch I region; other site 362948000582 G2 box; other site 362948000583 Switch II region; other site 362948000584 G3 box; other site 362948000585 G4 box; other site 362948000586 G5 box; other site 362948000587 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 362948000588 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 362948000589 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 362948000590 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 362948000591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948000592 catalytic core [active] 362948000593 CAAX protease self-immunity; Region: Abi; pfam02517 362948000594 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 362948000595 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 362948000596 Similar to 4-carboxymuconolactone decarboxylase; nonfunctional due to interrupting stop codon 362948000597 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 362948000598 substrate binding site [chemical binding]; other site 362948000599 THF binding site; other site 362948000600 zinc-binding site [ion binding]; other site 362948000601 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 362948000602 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 362948000603 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 362948000604 Walker A/P-loop; other site 362948000605 ATP binding site [chemical binding]; other site 362948000606 Q-loop/lid; other site 362948000607 ABC transporter signature motif; other site 362948000608 Walker B; other site 362948000609 D-loop; other site 362948000610 H-loop/switch region; other site 362948000611 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 362948000612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000613 dimer interface [polypeptide binding]; other site 362948000614 conserved gate region; other site 362948000615 ABC-ATPase subunit interface; other site 362948000616 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 362948000617 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 362948000618 metal binding site [ion binding]; metal-binding site 362948000619 dimer interface [polypeptide binding]; other site 362948000620 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 362948000621 dimer interface [polypeptide binding]; other site 362948000622 FMN binding site [chemical binding]; other site 362948000623 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 362948000624 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 362948000625 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 362948000626 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 362948000627 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 362948000628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948000630 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948000631 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 362948000632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 362948000633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948000634 catalytic residue [active] 362948000635 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362948000636 Similar to ABC transporter, ATP-binding protein; nonfunctional due to frameshift 362948000637 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948000638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948000639 putative PBP binding loops; other site 362948000640 dimer interface [polypeptide binding]; other site 362948000641 ABC-ATPase subunit interface; other site 362948000642 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 362948000643 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 362948000644 glucose-1-dehydrogenase; Provisional; Region: PRK08936 362948000645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948000646 NAD(P) binding site [chemical binding]; other site 362948000647 active site 362948000648 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 362948000649 Sugar transport protein; Region: Sugar_transport; cl19288 362948000650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948000651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948000652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362948000653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948000654 active site 362948000655 catalytic tetrad [active] 362948000656 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 362948000657 classical (c) SDRs; Region: SDR_c; cd05233 362948000658 NAD(P) binding site [chemical binding]; other site 362948000659 active site 362948000660 Similar to mucus binding protein Mbp1; nonfunctional due to interrupting stop codon 362948000661 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 362948000662 tetramer interface [polypeptide binding]; other site 362948000663 TPP-binding site [chemical binding]; other site 362948000664 heterodimer interface [polypeptide binding]; other site 362948000665 phosphorylation loop region [posttranslational modification] 362948000666 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 362948000667 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 362948000668 alpha subunit interface [polypeptide binding]; other site 362948000669 TPP binding site [chemical binding]; other site 362948000670 heterodimer interface [polypeptide binding]; other site 362948000671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362948000672 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 362948000673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362948000674 E3 interaction surface; other site 362948000675 lipoyl attachment site [posttranslational modification]; other site 362948000676 e3 binding domain; Region: E3_binding; pfam02817 362948000677 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 362948000678 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 362948000679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948000681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948000682 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948000683 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 362948000684 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 362948000685 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 362948000686 Protein of unknown function (DUF975); Region: DUF975; cl10504 362948000687 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 362948000688 active site 362948000689 catalytic triad [active] 362948000690 oxyanion hole [active] 362948000691 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 362948000692 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 362948000693 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362948000694 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362948000695 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362948000696 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 362948000697 putative substrate binding site [chemical binding]; other site 362948000698 putative ATP binding site [chemical binding]; other site 362948000699 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 362948000700 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362948000701 active site 362948000702 phosphorylation site [posttranslational modification] 362948000703 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362948000704 active site 362948000705 P-loop; other site 362948000706 phosphorylation site [posttranslational modification] 362948000707 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 362948000708 Predicted membrane protein [Function unknown]; Region: COG2364 362948000709 Amino acid permease; Region: AA_permease_2; pfam13520 362948000710 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948000711 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 362948000712 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948000713 Soluble P-type ATPase [General function prediction only]; Region: COG4087 362948000714 EDD domain protein, DegV family; Region: DegV; TIGR00762 362948000715 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 362948000716 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 362948000717 Ligand binding site; other site 362948000718 Putative Catalytic site; other site 362948000719 DXD motif; other site 362948000720 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 362948000721 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 362948000722 catalytic triad [active] 362948000723 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 362948000724 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 362948000725 CoenzymeA binding site [chemical binding]; other site 362948000726 subunit interaction site [polypeptide binding]; other site 362948000727 PHB binding site; other site 362948000728 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 362948000729 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362948000730 substrate binding site [chemical binding]; other site 362948000731 oxyanion hole (OAH) forming residues; other site 362948000732 trimer interface [polypeptide binding]; other site 362948000733 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 362948000734 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 362948000735 acyl-activating enzyme (AAE) consensus motif; other site 362948000736 putative AMP binding site [chemical binding]; other site 362948000737 putative active site [active] 362948000738 putative CoA binding site [chemical binding]; other site 362948000739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 362948000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948000741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948000742 putative substrate translocation pore; other site 362948000743 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948000744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 362948000745 Peptidase family C69; Region: Peptidase_C69; pfam03577 362948000746 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 362948000747 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 362948000748 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 362948000749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948000750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948000751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 362948000752 dimerization interface [polypeptide binding]; other site 362948000753 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362948000754 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 362948000755 active site 362948000756 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 362948000757 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 362948000758 acetolactate synthase; Reviewed; Region: PRK08617 362948000759 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362948000760 PYR/PP interface [polypeptide binding]; other site 362948000761 dimer interface [polypeptide binding]; other site 362948000762 TPP binding site [chemical binding]; other site 362948000763 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362948000764 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 362948000765 TPP-binding site [chemical binding]; other site 362948000766 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 362948000767 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 362948000768 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948000769 seryl-tRNA synthetase; Provisional; Region: PRK05431 362948000770 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 362948000771 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 362948000772 dimer interface [polypeptide binding]; other site 362948000773 active site 362948000774 motif 1; other site 362948000775 motif 2; other site 362948000776 motif 3; other site 362948000777 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 362948000778 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 362948000779 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 362948000780 dihydroorotase; Validated; Region: pyrC; PRK09357 362948000781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 362948000782 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 362948000783 active site 362948000784 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 362948000785 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 362948000786 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 362948000787 catalytic site [active] 362948000788 subunit interface [polypeptide binding]; other site 362948000789 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 362948000790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362948000791 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 362948000792 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 362948000793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362948000794 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948000795 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 362948000796 IMP binding site; other site 362948000797 dimer interface [polypeptide binding]; other site 362948000798 interdomain contacts; other site 362948000799 partial ornithine binding site; other site 362948000800 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 362948000801 heterodimer interface [polypeptide binding]; other site 362948000802 active site 362948000803 FMN binding site [chemical binding]; other site 362948000804 homodimer interface [polypeptide binding]; other site 362948000805 substrate binding site [chemical binding]; other site 362948000806 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 362948000807 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 362948000808 Clp amino terminal domain; Region: Clp_N; pfam02861 362948000809 Clp amino terminal domain; Region: Clp_N; pfam02861 362948000810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948000811 Walker A motif; other site 362948000812 ATP binding site [chemical binding]; other site 362948000813 Walker B motif; other site 362948000814 arginine finger; other site 362948000815 UvrB/uvrC motif; Region: UVR; pfam02151 362948000816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948000817 Walker A motif; other site 362948000818 ATP binding site [chemical binding]; other site 362948000819 Walker B motif; other site 362948000820 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362948000821 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 362948000822 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 362948000823 RPB12 interaction site [polypeptide binding]; other site 362948000824 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 362948000825 RPB1 interaction site [polypeptide binding]; other site 362948000826 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 362948000827 RPB10 interaction site [polypeptide binding]; other site 362948000828 RPB11 interaction site [polypeptide binding]; other site 362948000829 RPB3 interaction site [polypeptide binding]; other site 362948000830 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 362948000831 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 362948000832 beta and beta' interface [polypeptide binding]; other site 362948000833 beta' and sigma factor interface [polypeptide binding]; other site 362948000834 Zn-binding [ion binding]; other site 362948000835 active site region [active] 362948000836 catalytic site [active] 362948000837 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 362948000838 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 362948000839 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 362948000840 G-loop; other site 362948000841 DNA binding site [nucleotide binding] 362948000842 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 362948000843 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 362948000844 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 362948000845 S17 interaction site [polypeptide binding]; other site 362948000846 S8 interaction site; other site 362948000847 16S rRNA interaction site [nucleotide binding]; other site 362948000848 streptomycin interaction site [chemical binding]; other site 362948000849 23S rRNA interaction site [nucleotide binding]; other site 362948000850 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 362948000851 30S ribosomal protein S7; Validated; Region: PRK05302 362948000852 elongation factor G; Reviewed; Region: PRK12739 362948000853 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 362948000854 G1 box; other site 362948000855 putative GEF interaction site [polypeptide binding]; other site 362948000856 GTP/Mg2+ binding site [chemical binding]; other site 362948000857 Switch I region; other site 362948000858 G2 box; other site 362948000859 G3 box; other site 362948000860 Switch II region; other site 362948000861 G4 box; other site 362948000862 G5 box; other site 362948000863 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 362948000864 Elongation Factor G, domain II; Region: EFG_II; pfam14492 362948000865 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 362948000866 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 362948000867 NAD-dependent deacetylase; Provisional; Region: PRK00481 362948000868 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 362948000869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948000870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948000871 homodimer interface [polypeptide binding]; other site 362948000872 catalytic residue [active] 362948000873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948000874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948000875 active site 362948000876 phosphorylation site [posttranslational modification] 362948000877 intermolecular recognition site; other site 362948000878 dimerization interface [polypeptide binding]; other site 362948000879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362948000880 DNA binding site [nucleotide binding] 362948000881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 362948000882 HAMP domain; Region: HAMP; pfam00672 362948000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362948000884 dimer interface [polypeptide binding]; other site 362948000885 phosphorylation site [posttranslational modification] 362948000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948000887 ATP binding site [chemical binding]; other site 362948000888 Mg2+ binding site [ion binding]; other site 362948000889 G-X-G motif; other site 362948000890 Similar to transposase ISLasa4a, ISL3 family; nonfunctional due to interrupting stop codon 362948000891 Similar to transposase ISLasa4b, ISL3 family; nonfunctional due to interrupting stop codon 362948000892 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 362948000893 active site 362948000894 catalytic residues [active] 362948000895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948000896 D-galactonate transporter; Region: 2A0114; TIGR00893 362948000897 putative substrate translocation pore; other site 362948000898 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 362948000899 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 362948000900 TPP-binding site; other site 362948000901 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362948000902 PYR/PP interface [polypeptide binding]; other site 362948000903 dimer interface [polypeptide binding]; other site 362948000904 TPP binding site [chemical binding]; other site 362948000905 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362948000906 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948000907 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362948000908 Walker A/P-loop; other site 362948000909 ATP binding site [chemical binding]; other site 362948000910 Q-loop/lid; other site 362948000911 ABC transporter signature motif; other site 362948000912 Walker B; other site 362948000913 D-loop; other site 362948000914 H-loop/switch region; other site 362948000915 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362948000916 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 362948000917 FtsX-like permease family; Region: FtsX; pfam02687 362948000918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948000919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948000920 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362948000921 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948000922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948000923 Walker A/P-loop; other site 362948000924 ATP binding site [chemical binding]; other site 362948000925 Q-loop/lid; other site 362948000926 ABC transporter signature motif; other site 362948000927 Walker B; other site 362948000928 D-loop; other site 362948000929 H-loop/switch region; other site 362948000930 Similar to ABC transporter, ATP-binding protein; nonfunctional due to interrupting stop codon 362948000931 Similar to acetyltransferase, GNAT family; nonfunctional due to frameshift 362948000932 TPR repeat; Region: TPR_11; pfam13414 362948000933 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 362948000934 putative ADP-ribose binding site [chemical binding]; other site 362948000935 putative active site [active] 362948000936 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 362948000937 heat shock protein HtpX; Provisional; Region: PRK04897 362948000938 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 362948000939 Part of AAA domain; Region: AAA_19; pfam13245 362948000940 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948000941 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 362948000942 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 362948000943 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 362948000944 active site 362948000945 HIGH motif; other site 362948000946 dimer interface [polypeptide binding]; other site 362948000947 KMSKS motif; other site 362948000948 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 362948000949 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 362948000950 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 362948000951 Walker A/P-loop; other site 362948000952 ATP binding site [chemical binding]; other site 362948000953 Q-loop/lid; other site 362948000954 ABC transporter signature motif; other site 362948000955 Walker B; other site 362948000956 D-loop; other site 362948000957 H-loop/switch region; other site 362948000958 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 362948000959 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 362948000960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948000961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948000962 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948000963 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 362948000964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948000965 substrate binding pocket [chemical binding]; other site 362948000966 membrane-bound complex binding site; other site 362948000967 hinge residues; other site 362948000968 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 362948000969 homodimer interface [polypeptide binding]; other site 362948000970 catalytic residues [active] 362948000971 NAD binding site [chemical binding]; other site 362948000972 substrate binding pocket [chemical binding]; other site 362948000973 flexible flap; other site 362948000974 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 362948000975 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 362948000976 active site 362948000977 HIGH motif; other site 362948000978 KMSKS motif; other site 362948000979 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 362948000980 tRNA binding surface [nucleotide binding]; other site 362948000981 anticodon binding site; other site 362948000982 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 362948000983 dimer interface [polypeptide binding]; other site 362948000984 putative tRNA-binding site [nucleotide binding]; other site 362948000985 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 362948000986 active site 362948000987 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 362948000988 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 362948000989 putative active site [active] 362948000990 putative metal binding site [ion binding]; other site 362948000991 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 362948000992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948000993 S-adenosylmethionine binding site [chemical binding]; other site 362948000994 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 362948000995 Putative lysophospholipase; Region: Hydrolase_4; cl19140 362948000996 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 362948000997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948000998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948000999 homodimer interface [polypeptide binding]; other site 362948001000 catalytic residue [active] 362948001001 Arginine repressor [Transcription]; Region: ArgR; COG1438 362948001002 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 362948001003 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 362948001004 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 362948001005 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362948001006 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 362948001007 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 362948001008 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 362948001009 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948001010 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 362948001011 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948001012 Int/Topo IB signature motif; other site 362948001013 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 362948001014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 362948001015 P-loop; other site 362948001016 Magnesium ion binding site [ion binding]; other site 362948001017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948001018 non-specific DNA binding site [nucleotide binding]; other site 362948001019 salt bridge; other site 362948001020 sequence-specific DNA binding site [nucleotide binding]; other site 362948001021 SOS regulatory protein LexA; Region: lexA; TIGR00498 362948001022 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 362948001023 Catalytic site [active] 362948001024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948001025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948001026 non-specific DNA binding site [nucleotide binding]; other site 362948001027 salt bridge; other site 362948001028 sequence-specific DNA binding site [nucleotide binding]; other site 362948001029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948001030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948001031 non-specific DNA binding site [nucleotide binding]; other site 362948001032 salt bridge; other site 362948001033 sequence-specific DNA binding site [nucleotide binding]; other site 362948001034 AntA/AntB antirepressor; Region: AntA; pfam08346 362948001035 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 362948001036 Protein of unknown function (DUF968); Region: DUF968; pfam06147 362948001037 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 362948001038 Helix-turn-helix domain; Region: HTH_17; pfam12728 362948001039 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 362948001040 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 362948001041 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 362948001042 active site 362948001043 Phage terminase, small subunit; Region: Terminase_4; cl01525 362948001044 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 362948001045 Phage Terminase; Region: Terminase_1; pfam03354 362948001046 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 362948001047 Phage portal protein; Region: Phage_portal; pfam04860 362948001048 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 362948001049 oligomer interface [polypeptide binding]; other site 362948001050 active site residues [active] 362948001051 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 362948001052 Phage capsid family; Region: Phage_capsid; pfam05065 362948001053 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 362948001054 oligomerization interface [polypeptide binding]; other site 362948001055 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 362948001056 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 362948001057 Protein of unknown function (DUF806); Region: DUF806; pfam05657 362948001058 Phage major tail protein; Region: Phage_tail; pfam04630 362948001059 Phage-related minor tail protein [Function unknown]; Region: COG5280 362948001060 tape measure domain; Region: tape_meas_nterm; TIGR02675 362948001061 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 362948001062 Phage tail protein; Region: Sipho_tail; pfam05709 362948001063 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 362948001064 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 362948001065 Peptidase family M23; Region: Peptidase_M23; pfam01551 362948001066 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 362948001067 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 362948001068 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 362948001069 active site 362948001070 Proteins of 100 residues with WXG; Region: WXG100; cl02005 362948001071 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 362948001072 TolA protein; Region: tolA_full; TIGR02794 362948001073 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 362948001074 active site 362948001075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948001076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948001077 argininosuccinate lyase; Provisional; Region: PRK00855 362948001078 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 362948001079 active sites [active] 362948001080 tetramer interface [polypeptide binding]; other site 362948001081 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 362948001082 ANP binding site [chemical binding]; other site 362948001083 Substrate Binding Site II [chemical binding]; other site 362948001084 Substrate Binding Site I [chemical binding]; other site 362948001085 aminotransferase A; Validated; Region: PRK07683 362948001086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948001087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948001088 homodimer interface [polypeptide binding]; other site 362948001089 catalytic residue [active] 362948001090 D-lactate dehydrogenase; Validated; Region: PRK08605 362948001091 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 362948001092 homodimer interface [polypeptide binding]; other site 362948001093 ligand binding site [chemical binding]; other site 362948001094 NAD binding site [chemical binding]; other site 362948001095 catalytic site [active] 362948001096 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 362948001097 BDLF3; Provisional; Region: PHA03255 362948001098 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001099 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001100 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001101 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001102 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001103 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001104 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001105 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948001107 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948001108 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948001109 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 362948001110 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 362948001111 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 362948001112 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 362948001113 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 362948001114 DNA binding residues [nucleotide binding] 362948001115 putative dimer interface [polypeptide binding]; other site 362948001116 pur operon repressor; Provisional; Region: PRK09213 362948001117 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 362948001118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948001119 active site 362948001120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948001121 H+ Antiporter protein; Region: 2A0121; TIGR00900 362948001122 putative substrate translocation pore; other site 362948001123 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 362948001124 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 362948001125 Substrate binding site; other site 362948001126 Mg++ binding site; other site 362948001127 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 362948001128 active site 362948001129 substrate binding site [chemical binding]; other site 362948001130 CoA binding site [chemical binding]; other site 362948001131 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 362948001132 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 362948001133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948001134 active site 362948001135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 362948001136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948001137 Coenzyme A binding pocket [chemical binding]; other site 362948001138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948001139 active site 362948001140 catalytic tetrad [active] 362948001141 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 362948001142 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 362948001143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948001144 ABC transporter; Region: ABC_tran_2; pfam12848 362948001145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948001146 metal-dependent hydrolase; Provisional; Region: PRK00685 362948001147 Biotin operon repressor [Transcription]; Region: BirA; COG1654 362948001148 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 362948001149 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 362948001150 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 362948001151 YibE/F-like protein; Region: YibE_F; pfam07907 362948001152 YibE/F-like protein; Region: YibE_F; pfam07907 362948001153 Lagovirus protein of unknown function (DUF840); Region: DUF840; pfam05801 362948001154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948001155 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 362948001156 Walker A motif; other site 362948001157 ATP binding site [chemical binding]; other site 362948001158 Walker B motif; other site 362948001159 arginine finger; other site 362948001160 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 362948001161 OsmC-like protein; Region: OsmC; cl00767 362948001162 AAA domain; Region: AAA_30; pfam13604 362948001163 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948001164 Protein of unknown function, DUF606; Region: DUF606; pfam04657 362948001165 sugar phosphate phosphatase; Provisional; Region: PRK10513 362948001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948001167 active site 362948001168 motif I; other site 362948001169 motif II; other site 362948001170 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948001171 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 362948001172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948001173 Zn2+ binding site [ion binding]; other site 362948001174 Mg2+ binding site [ion binding]; other site 362948001175 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 362948001176 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 362948001177 catalytic triad [active] 362948001178 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 362948001179 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 362948001180 CTP synthetase; Validated; Region: pyrG; PRK05380 362948001181 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 362948001182 Catalytic site [active] 362948001183 active site 362948001184 UTP binding site [chemical binding]; other site 362948001185 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 362948001186 active site 362948001187 putative oxyanion hole; other site 362948001188 catalytic triad [active] 362948001189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 362948001190 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 362948001191 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 362948001192 hinge; other site 362948001193 active site 362948001194 transcription termination factor Rho; Provisional; Region: rho; PRK09376 362948001195 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 362948001196 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 362948001197 RNA binding site [nucleotide binding]; other site 362948001198 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 362948001199 multimer interface [polypeptide binding]; other site 362948001200 Walker A motif; other site 362948001201 ATP binding site [chemical binding]; other site 362948001202 Walker B motif; other site 362948001203 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 362948001204 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 362948001205 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 362948001206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948001207 ATP binding site [chemical binding]; other site 362948001208 putative Mg++ binding site [ion binding]; other site 362948001209 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 362948001210 WxL domain surface cell wall-binding; Region: WxL; pfam13731 362948001211 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 362948001212 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 362948001213 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362948001214 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; cl19419 362948001215 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 362948001216 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362948001217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948001218 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362948001219 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 362948001220 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362948001221 ATP binding site [chemical binding]; other site 362948001222 Mg++ binding site [ion binding]; other site 362948001223 motif III; other site 362948001224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948001225 nucleotide binding region [chemical binding]; other site 362948001226 ATP-binding site [chemical binding]; other site 362948001227 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 362948001228 alanine racemase; Reviewed; Region: alr; PRK00053 362948001229 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 362948001230 active site 362948001231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362948001232 dimer interface [polypeptide binding]; other site 362948001233 substrate binding site [chemical binding]; other site 362948001234 catalytic residues [active] 362948001235 PemK-like protein; Region: PemK; pfam02452 362948001236 Protein of unknown function DUF72; Region: DUF72; pfam01904 362948001237 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 362948001238 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 362948001239 active site 362948001240 catalytic residues [active] 362948001241 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 362948001242 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 362948001243 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 362948001244 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 362948001245 Hepatocellular carcinoma-associated antigen 59; Region: Hep_59; pfam07052 362948001246 recombination regulator RecX; Provisional; Region: recX; PRK14135 362948001247 TRAM domain; Region: TRAM; pfam01938 362948001248 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 362948001249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948001250 S-adenosylmethionine binding site [chemical binding]; other site 362948001251 hypothetical protein; Provisional; Region: PRK13662 362948001252 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 362948001253 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 362948001254 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 362948001255 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 362948001256 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 362948001257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948001258 Walker A/P-loop; other site 362948001259 ATP binding site [chemical binding]; other site 362948001260 Q-loop/lid; other site 362948001261 ABC transporter signature motif; other site 362948001262 Walker B; other site 362948001263 D-loop; other site 362948001264 H-loop/switch region; other site 362948001265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948001266 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 362948001267 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 362948001268 G1 box; other site 362948001269 putative GEF interaction site [polypeptide binding]; other site 362948001270 GTP/Mg2+ binding site [chemical binding]; other site 362948001271 Switch I region; other site 362948001272 G2 box; other site 362948001273 G3 box; other site 362948001274 Switch II region; other site 362948001275 G4 box; other site 362948001276 G5 box; other site 362948001277 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 362948001278 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 362948001279 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 362948001280 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 362948001281 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 362948001282 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 362948001283 Similar to sugar transport protein; nonfunctional due to insertion of IS element 362948001284 Similar to transposase ISLasa4d, ISL3 family; nonfunctional due to interrupting stop codon 362948001285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362948001286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362948001287 DNA binding site [nucleotide binding] 362948001288 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 362948001289 putative dimerization interface [polypeptide binding]; other site 362948001290 putative ligand binding site [chemical binding]; other site 362948001291 galactokinase; Provisional; Region: PRK05322 362948001292 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 362948001293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362948001294 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 362948001295 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 362948001296 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 362948001297 NAD binding site [chemical binding]; other site 362948001298 homodimer interface [polypeptide binding]; other site 362948001299 active site 362948001300 substrate binding site [chemical binding]; other site 362948001301 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 362948001302 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 362948001303 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 362948001304 Similar to alpha-galactosidase; nonfunctional due to interrupting stop codon 362948001305 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001306 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 362948001307 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 362948001308 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 362948001309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948001310 Walker A motif; other site 362948001311 ATP binding site [chemical binding]; other site 362948001312 Walker B motif; other site 362948001313 arginine finger; other site 362948001314 UvrB/uvrC motif; Region: UVR; pfam02151 362948001315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948001316 Walker A motif; other site 362948001317 ATP binding site [chemical binding]; other site 362948001318 Walker B motif; other site 362948001319 arginine finger; other site 362948001320 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362948001321 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362948001322 dimerization domain swap beta strand [polypeptide binding]; other site 362948001323 regulatory protein interface [polypeptide binding]; other site 362948001324 active site 362948001325 regulatory phosphorylation site [posttranslational modification]; other site 362948001326 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 362948001327 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 362948001328 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362948001329 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362948001330 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948001331 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 362948001332 putative ADP-binding pocket [chemical binding]; other site 362948001333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948001334 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948001335 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 362948001336 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 362948001337 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 362948001338 Sulfatase; Region: Sulfatase; pfam00884 362948001339 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 362948001340 active site 362948001341 nucleotide-binding site [chemical binding]; other site 362948001342 adaptor protein; Provisional; Region: PRK02315 362948001343 Competence protein CoiA-like family; Region: CoiA; cl11541 362948001344 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 362948001345 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 362948001346 active site 362948001347 Zn binding site [ion binding]; other site 362948001348 Thioredoxin; Region: Thioredoxin_5; pfam13743 362948001349 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 362948001350 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 362948001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948001352 dimer interface [polypeptide binding]; other site 362948001353 conserved gate region; other site 362948001354 putative PBP binding loops; other site 362948001355 ABC-ATPase subunit interface; other site 362948001356 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 362948001357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948001358 dimer interface [polypeptide binding]; other site 362948001359 conserved gate region; other site 362948001360 putative PBP binding loops; other site 362948001361 ABC-ATPase subunit interface; other site 362948001362 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 362948001363 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 362948001364 Walker A/P-loop; other site 362948001365 ATP binding site [chemical binding]; other site 362948001366 Q-loop/lid; other site 362948001367 ABC transporter signature motif; other site 362948001368 Walker B; other site 362948001369 D-loop; other site 362948001370 H-loop/switch region; other site 362948001371 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 362948001372 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 362948001373 Walker A/P-loop; other site 362948001374 ATP binding site [chemical binding]; other site 362948001375 Q-loop/lid; other site 362948001376 ABC transporter signature motif; other site 362948001377 Walker B; other site 362948001378 D-loop; other site 362948001379 H-loop/switch region; other site 362948001380 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 362948001381 PhoU domain; Region: PhoU; pfam01895 362948001382 PhoU domain; Region: PhoU; pfam01895 362948001383 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362948001384 intersubunit interface [polypeptide binding]; other site 362948001385 active site 362948001386 zinc binding site [ion binding]; other site 362948001387 Na+ binding site [ion binding]; other site 362948001388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948001389 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948001390 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948001391 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 362948001392 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 362948001393 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 362948001394 Haemolysin-III related; Region: HlyIII; cl03831 362948001395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948001396 dimerization interface [polypeptide binding]; other site 362948001397 putative DNA binding site [nucleotide binding]; other site 362948001398 putative Zn2+ binding site [ion binding]; other site 362948001399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948001400 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948001401 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948001402 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 362948001403 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 362948001404 RNA/DNA hybrid binding site [nucleotide binding]; other site 362948001405 active site 362948001406 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 362948001407 phosphodiesterase; Provisional; Region: PRK12704 362948001408 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 362948001409 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 362948001410 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 362948001411 active site 362948001412 catabolite control protein A; Region: ccpA; TIGR01481 362948001413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362948001414 DNA binding site [nucleotide binding] 362948001415 domain linker motif; other site 362948001416 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 362948001417 dimerization interface [polypeptide binding]; other site 362948001418 effector binding site; other site 362948001419 Predicted integral membrane protein [Function unknown]; Region: COG5652 362948001420 hypothetical protein; Validated; Region: PRK00110 362948001421 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 362948001422 substrate binding site [chemical binding]; other site 362948001423 dimer interface [polypeptide binding]; other site 362948001424 ATP binding site [chemical binding]; other site 362948001425 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 362948001426 Walker A motif; other site 362948001427 ATP binding site [chemical binding]; other site 362948001428 Walker B motif; other site 362948001429 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362948001430 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362948001431 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 362948001432 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 362948001433 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 362948001434 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 362948001435 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 362948001436 Methyltransferase domain; Region: Methyltransf_26; pfam13659 362948001437 Similar to transposase ISLasa4g, ISL3 family; nonfunctional due to interrupting stop codon 362948001438 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 362948001439 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 362948001440 putative active site [active] 362948001441 putative metal binding site [ion binding]; other site 362948001442 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 362948001443 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 362948001444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948001445 active site 362948001446 motif I; other site 362948001447 motif II; other site 362948001448 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 362948001449 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 362948001450 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 362948001451 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 362948001452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948001453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948001454 general stress protein 13; Validated; Region: PRK08059 362948001455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362948001456 RNA binding site [nucleotide binding]; other site 362948001457 S-adenosylmethionine synthetase; Validated; Region: PRK05250 362948001458 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 362948001459 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 362948001460 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 362948001461 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 362948001462 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 362948001463 active site 362948001464 HIGH motif; other site 362948001465 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 362948001466 KMSKS motif; other site 362948001467 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 362948001468 tRNA binding surface [nucleotide binding]; other site 362948001469 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 362948001470 stage V sporulation protein B; Region: spore_V_B; TIGR02900 362948001471 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 362948001472 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 362948001473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948001474 RNA binding surface [nucleotide binding]; other site 362948001475 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 362948001476 active site 362948001477 uracil binding [chemical binding]; other site 362948001478 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 362948001479 putative substrate binding site [chemical binding]; other site 362948001480 putative ATP binding site [chemical binding]; other site 362948001481 dipeptidase PepV; Reviewed; Region: PRK07318 362948001482 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 362948001483 active site 362948001484 metal binding site [ion binding]; metal-binding site 362948001485 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 362948001486 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 362948001487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948001488 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362948001489 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 362948001490 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 362948001491 dimer interface [polypeptide binding]; other site 362948001492 active site 362948001493 CoA binding pocket [chemical binding]; other site 362948001494 acyl carrier protein; Provisional; Region: acpP; PRK00982 362948001495 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 362948001496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 362948001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948001498 NAD(P) binding site [chemical binding]; other site 362948001499 active site 362948001500 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 362948001501 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 362948001502 dimer interface [polypeptide binding]; other site 362948001503 active site 362948001504 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 362948001505 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 362948001506 carboxyltransferase (CT) interaction site; other site 362948001507 biotinylation site [posttranslational modification]; other site 362948001508 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 362948001509 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 362948001510 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362948001511 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948001512 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 362948001513 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 362948001514 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 362948001515 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 362948001516 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 362948001517 NAD binding site [chemical binding]; other site 362948001518 homotetramer interface [polypeptide binding]; other site 362948001519 homodimer interface [polypeptide binding]; other site 362948001520 substrate binding site [chemical binding]; other site 362948001521 active site 362948001522 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 362948001523 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 362948001524 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 362948001525 Similar to transposase ISLasa4h, ISL3 family; nonfunctional due to interrupting stop codon 362948001526 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 362948001527 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 362948001528 active site 362948001529 dimer interface [polypeptide binding]; other site 362948001530 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 362948001531 dimer interface [polypeptide binding]; other site 362948001532 active site 362948001533 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 362948001534 Sulfatase; Region: Sulfatase; pfam00884 362948001535 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 362948001536 amphipathic channel; other site 362948001537 Asn-Pro-Ala signature motifs; other site 362948001538 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 362948001539 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 362948001540 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 362948001541 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362948001542 putative trimer interface [polypeptide binding]; other site 362948001543 putative CoA binding site [chemical binding]; other site 362948001544 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 362948001545 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 362948001546 metal binding site [ion binding]; metal-binding site 362948001547 putative dimer interface [polypeptide binding]; other site 362948001548 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 362948001549 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362948001550 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 362948001551 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 362948001552 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 362948001553 Transglycosylase; Region: Transgly; pfam00912 362948001554 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 362948001555 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 362948001556 Protein of unknown function (DUF964); Region: DUF964; cl01483 362948001557 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 362948001558 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 362948001559 generic binding surface I; other site 362948001560 generic binding surface II; other site 362948001561 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 362948001562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948001563 Zn2+ binding site [ion binding]; other site 362948001564 Mg2+ binding site [ion binding]; other site 362948001565 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 362948001566 SurA N-terminal domain; Region: SurA_N_3; cl07813 362948001567 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 362948001568 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 362948001569 HIT family signature motif; other site 362948001570 catalytic residue [active] 362948001571 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362948001572 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 362948001573 Walker A/P-loop; other site 362948001574 ATP binding site [chemical binding]; other site 362948001575 Q-loop/lid; other site 362948001576 ABC transporter signature motif; other site 362948001577 Walker B; other site 362948001578 D-loop; other site 362948001579 H-loop/switch region; other site 362948001580 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 362948001581 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 362948001582 Phosphotransferase enzyme family; Region: APH; pfam01636 362948001583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948001584 S-adenosylmethionine binding site [chemical binding]; other site 362948001585 Predicted small secreted protein [Function unknown]; Region: COG5584 362948001586 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362948001587 catalytic residues [active] 362948001588 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 362948001589 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 362948001590 putative tRNA-binding site [nucleotide binding]; other site 362948001591 Similar to cell division protein FtsK; nonfunctional due to truncation; Nonfunctional due to truncation 362948001592 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 362948001593 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362948001594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948001595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362948001596 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 362948001597 active site 2 [active] 362948001598 active site 1 [active] 362948001599 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 362948001600 DNA polymerase I; Provisional; Region: PRK05755 362948001601 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 362948001602 active site 362948001603 metal binding site 1 [ion binding]; metal-binding site 362948001604 putative 5' ssDNA interaction site; other site 362948001605 metal binding site 3; metal-binding site 362948001606 metal binding site 2 [ion binding]; metal-binding site 362948001607 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 362948001608 putative DNA binding site [nucleotide binding]; other site 362948001609 putative metal binding site [ion binding]; other site 362948001610 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 362948001611 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 362948001612 active site 362948001613 DNA binding site [nucleotide binding] 362948001614 catalytic site [active] 362948001615 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 362948001616 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 362948001617 DNA binding site [nucleotide binding] 362948001618 catalytic residue [active] 362948001619 H2TH interface [polypeptide binding]; other site 362948001620 putative catalytic residues [active] 362948001621 turnover-facilitating residue; other site 362948001622 intercalation triad [nucleotide binding]; other site 362948001623 8OG recognition residue [nucleotide binding]; other site 362948001624 putative reading head residues; other site 362948001625 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 362948001626 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 362948001627 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 362948001628 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 362948001629 CoA-binding site [chemical binding]; other site 362948001630 ATP-binding [chemical binding]; other site 362948001631 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 362948001632 ATP cone domain; Region: ATP-cone; pfam03477 362948001633 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 362948001634 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 362948001635 primosomal protein DnaI; Reviewed; Region: PRK08939 362948001636 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 362948001637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948001638 Walker A motif; other site 362948001639 ATP binding site [chemical binding]; other site 362948001640 Walker B motif; other site 362948001641 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 362948001642 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 362948001643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 362948001644 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 362948001645 active site 362948001646 dimer interface [polypeptide binding]; other site 362948001647 motif 1; other site 362948001648 motif 2; other site 362948001649 motif 3; other site 362948001650 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 362948001651 anticodon binding site; other site 362948001652 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 362948001653 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 362948001654 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 362948001655 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 362948001656 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 362948001657 23S rRNA binding site [nucleotide binding]; other site 362948001658 L21 binding site [polypeptide binding]; other site 362948001659 L13 binding site [polypeptide binding]; other site 362948001660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948001661 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948001662 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948001663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948001664 active site 362948001665 motif I; other site 362948001666 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 362948001667 motif II; other site 362948001668 GTPase YqeH; Provisional; Region: PRK13796 362948001669 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 362948001670 GTP/Mg2+ binding site [chemical binding]; other site 362948001671 G4 box; other site 362948001672 G5 box; other site 362948001673 G1 box; other site 362948001674 Switch I region; other site 362948001675 G2 box; other site 362948001676 G3 box; other site 362948001677 Switch II region; other site 362948001678 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 362948001679 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 362948001680 active site 362948001681 (T/H)XGH motif; other site 362948001682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948001683 Zn2+ binding site [ion binding]; other site 362948001684 Mg2+ binding site [ion binding]; other site 362948001685 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 362948001686 Similar to methyltransferase; nonfunctional due to frameshift 362948001687 hypothetical protein; Provisional; Region: PRK13670 362948001688 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 362948001689 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 362948001690 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 362948001691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 362948001692 putative acyl-acceptor binding pocket; other site 362948001693 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 362948001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948001695 S-adenosylmethionine binding site [chemical binding]; other site 362948001696 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 362948001697 GIY-YIG motif/motif A; other site 362948001698 putative active site [active] 362948001699 putative metal binding site [ion binding]; other site 362948001700 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 362948001701 rRNA interaction site [nucleotide binding]; other site 362948001702 S8 interaction site; other site 362948001703 putative laminin-1 binding site; other site 362948001704 elongation factor Ts; Provisional; Region: tsf; PRK09377 362948001705 UBA/TS-N domain; Region: UBA; pfam00627 362948001706 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 362948001707 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 362948001708 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 362948001709 Substrate-binding site [chemical binding]; other site 362948001710 Substrate specificity [chemical binding]; other site 362948001711 AIR carboxylase; Region: AIRC; pfam00731 362948001712 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 362948001713 ATP-grasp domain; Region: ATP-grasp; pfam02222 362948001714 adenylosuccinate lyase; Provisional; Region: PRK07492 362948001715 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 362948001716 tetramer interface [polypeptide binding]; other site 362948001717 active site 362948001718 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 362948001719 active site 362948001720 Zinc-finger double-stranded RNA-binding; Region: zf-C2H2_jaz; cl17721 362948001721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948001722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948001723 active site 362948001724 phosphorylation site [posttranslational modification] 362948001725 intermolecular recognition site; other site 362948001726 dimerization interface [polypeptide binding]; other site 362948001727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362948001728 DNA binding site [nucleotide binding] 362948001729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 362948001730 HAMP domain; Region: HAMP; pfam00672 362948001731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362948001732 dimer interface [polypeptide binding]; other site 362948001733 phosphorylation site [posttranslational modification] 362948001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948001735 ATP binding site [chemical binding]; other site 362948001736 Mg2+ binding site [ion binding]; other site 362948001737 G-X-G motif; other site 362948001738 OxaA-like protein precursor; Provisional; Region: PRK02463 362948001739 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 362948001740 Acylphosphatase; Region: Acylphosphatase; pfam00708 362948001741 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 362948001742 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 362948001743 dimer interface [polypeptide binding]; other site 362948001744 active site 362948001745 MAEBL; Provisional; Region: PTZ00121 362948001746 elongation factor P; Validated; Region: PRK00529 362948001747 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 362948001748 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 362948001749 RNA binding site [nucleotide binding]; other site 362948001750 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 362948001751 RNA binding site [nucleotide binding]; other site 362948001752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 362948001753 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 362948001754 putative RNA binding site [nucleotide binding]; other site 362948001755 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 362948001756 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 362948001757 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 362948001758 homodimer interface [polypeptide binding]; other site 362948001759 NADP binding site [chemical binding]; other site 362948001760 substrate binding site [chemical binding]; other site 362948001761 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 362948001762 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 362948001763 generic binding surface II; other site 362948001764 generic binding surface I; other site 362948001765 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 362948001766 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 362948001767 substrate binding pocket [chemical binding]; other site 362948001768 chain length determination region; other site 362948001769 substrate-Mg2+ binding site; other site 362948001770 catalytic residues [active] 362948001771 aspartate-rich region 1; other site 362948001772 active site lid residues [active] 362948001773 aspartate-rich region 2; other site 362948001774 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 362948001775 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948001776 RNA binding surface [nucleotide binding]; other site 362948001777 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 362948001778 Arginine repressor [Transcription]; Region: ArgR; COG1438 362948001779 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 362948001780 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 362948001781 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 362948001782 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 362948001783 Walker A/P-loop; other site 362948001784 ATP binding site [chemical binding]; other site 362948001785 Q-loop/lid; other site 362948001786 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 362948001787 ABC transporter signature motif; other site 362948001788 Walker B; other site 362948001789 D-loop; other site 362948001790 H-loop/switch region; other site 362948001791 LexA repressor; Validated; Region: PRK00215 362948001792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948001793 putative DNA binding site [nucleotide binding]; other site 362948001794 putative Zn2+ binding site [ion binding]; other site 362948001795 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 362948001796 Catalytic site [active] 362948001797 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 362948001798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 362948001799 Predicted GTPase [General function prediction only]; Region: COG0218 362948001800 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 362948001801 G1 box; other site 362948001802 GTP/Mg2+ binding site [chemical binding]; other site 362948001803 Switch I region; other site 362948001804 G2 box; other site 362948001805 G3 box; other site 362948001806 Switch II region; other site 362948001807 G4 box; other site 362948001808 G5 box; other site 362948001809 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 362948001810 putative metal binding site [ion binding]; other site 362948001811 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 362948001812 Helix-turn-helix domain; Region: HTH_28; pfam13518 362948001813 putative transposase OrfB; Reviewed; Region: PHA02517 362948001814 HTH-like domain; Region: HTH_21; pfam13276 362948001815 Integrase core domain; Region: rve; pfam00665 362948001816 Integrase core domain; Region: rve_3; pfam13683 362948001817 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 362948001818 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 362948001819 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 362948001820 Rhomboid family; Region: Rhomboid; pfam01694 362948001821 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 362948001822 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 362948001823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362948001824 nucleotide binding site [chemical binding]; other site 362948001825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 362948001826 active site residue [active] 362948001827 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 362948001828 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 362948001829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 362948001830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948001831 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 362948001832 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 362948001833 DNA binding residues [nucleotide binding] 362948001834 putative dimer interface [polypeptide binding]; other site 362948001835 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 362948001836 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 362948001837 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 362948001838 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 362948001839 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 362948001840 DNA binding site [nucleotide binding] 362948001841 active site 362948001842 Domain of unknown function (DUF956); Region: DUF956; pfam06115 362948001843 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 362948001844 putative nucleotide binding site [chemical binding]; other site 362948001845 uridine monophosphate binding site [chemical binding]; other site 362948001846 homohexameric interface [polypeptide binding]; other site 362948001847 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 362948001848 hinge region; other site 362948001849 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 362948001850 active site 362948001851 dimer interface [polypeptide binding]; other site 362948001852 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 362948001853 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 362948001854 RIP metalloprotease RseP; Region: TIGR00054 362948001855 active site 362948001856 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 362948001857 protein binding site [polypeptide binding]; other site 362948001858 putative substrate binding region [chemical binding]; other site 362948001859 prolyl-tRNA synthetase; Provisional; Region: PRK09194 362948001860 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 362948001861 dimer interface [polypeptide binding]; other site 362948001862 motif 1; other site 362948001863 active site 362948001864 motif 2; other site 362948001865 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 362948001866 putative deacylase active site [active] 362948001867 motif 3; other site 362948001868 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 362948001869 anticodon binding site; other site 362948001870 DNA polymerase III PolC; Validated; Region: polC; PRK00448 362948001871 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 362948001872 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 362948001873 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 362948001874 generic binding surface II; other site 362948001875 generic binding surface I; other site 362948001876 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 362948001877 active site 362948001878 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 362948001879 active site 362948001880 catalytic site [active] 362948001881 substrate binding site [chemical binding]; other site 362948001882 putative PHP Thumb interface [polypeptide binding]; other site 362948001883 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 362948001884 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 362948001885 Sm and related proteins; Region: Sm_like; cl00259 362948001886 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 362948001887 putative oligomer interface [polypeptide binding]; other site 362948001888 putative RNA binding site [nucleotide binding]; other site 362948001889 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 362948001890 NusA N-terminal domain; Region: NusA_N; pfam08529 362948001891 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 362948001892 RNA binding site [nucleotide binding]; other site 362948001893 homodimer interface [polypeptide binding]; other site 362948001894 NusA-like KH domain; Region: KH_5; pfam13184 362948001895 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 362948001896 G-X-X-G motif; other site 362948001897 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 362948001898 putative RNA binding cleft [nucleotide binding]; other site 362948001899 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 362948001900 translation initiation factor IF-2; Validated; Region: infB; PRK05306 362948001901 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 362948001902 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 362948001903 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 362948001904 G1 box; other site 362948001905 putative GEF interaction site [polypeptide binding]; other site 362948001906 GTP/Mg2+ binding site [chemical binding]; other site 362948001907 Switch I region; other site 362948001908 G2 box; other site 362948001909 G3 box; other site 362948001910 Switch II region; other site 362948001911 G4 box; other site 362948001912 G5 box; other site 362948001913 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 362948001914 Translation-initiation factor 2; Region: IF-2; pfam11987 362948001915 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 362948001916 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 362948001917 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 362948001918 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 362948001919 RNA binding site [nucleotide binding]; other site 362948001920 active site 362948001921 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 362948001922 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 362948001923 active site 362948001924 Riboflavin kinase; Region: Flavokinase; smart00904 362948001925 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 362948001926 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 362948001927 HrcA protein C terminal domain; Region: HrcA; pfam01628 362948001928 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 362948001929 dimer interface [polypeptide binding]; other site 362948001930 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 362948001931 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 362948001932 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 362948001933 nucleotide binding site [chemical binding]; other site 362948001934 NEF interaction site [polypeptide binding]; other site 362948001935 SBD interface [polypeptide binding]; other site 362948001936 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 362948001937 chaperone protein DnaJ; Provisional; Region: PRK14276 362948001938 HSP70 interaction site [polypeptide binding]; other site 362948001939 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 362948001940 substrate binding site [polypeptide binding]; other site 362948001941 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 362948001942 Zn binding sites [ion binding]; other site 362948001943 dimer interface [polypeptide binding]; other site 362948001944 GTP-binding protein LepA; Provisional; Region: PRK05433 362948001945 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 362948001946 G1 box; other site 362948001947 putative GEF interaction site [polypeptide binding]; other site 362948001948 GTP/Mg2+ binding site [chemical binding]; other site 362948001949 Switch I region; other site 362948001950 G2 box; other site 362948001951 G3 box; other site 362948001952 Switch II region; other site 362948001953 G4 box; other site 362948001954 G5 box; other site 362948001955 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 362948001956 Elongation Factor G, domain II; Region: EFG_II; pfam14492 362948001957 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 362948001958 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 362948001959 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948001960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948001961 substrate binding pocket [chemical binding]; other site 362948001962 membrane-bound complex binding site; other site 362948001963 hinge residues; other site 362948001964 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948001966 dimer interface [polypeptide binding]; other site 362948001967 conserved gate region; other site 362948001968 putative PBP binding loops; other site 362948001969 ABC-ATPase subunit interface; other site 362948001970 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362948001971 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362948001972 Walker A/P-loop; other site 362948001973 ATP binding site [chemical binding]; other site 362948001974 Q-loop/lid; other site 362948001975 ABC transporter signature motif; other site 362948001976 Walker B; other site 362948001977 D-loop; other site 362948001978 H-loop/switch region; other site 362948001979 Beta-lactamase; Region: Beta-lactamase; pfam00144 362948001980 putative transposase OrfB; Reviewed; Region: PHA02517 362948001981 HTH-like domain; Region: HTH_21; pfam13276 362948001982 Integrase core domain; Region: rve; pfam00665 362948001983 Integrase core domain; Region: rve_2; pfam13333 362948001984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948001985 Helix-turn-helix domain; Region: HTH_28; pfam13518 362948001986 Transposase; Region: HTH_Tnp_1; cl17663 362948001987 Helix-turn-helix domain; Region: HTH_28; pfam13518 362948001988 Winged helix-turn helix; Region: HTH_29; pfam13551 362948001989 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 362948001990 catalytic triad [active] 362948001991 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 362948001992 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948001993 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 362948001994 thymidine kinase; Provisional; Region: PRK04296 362948001995 peptide chain release factor 1; Validated; Region: prfA; PRK00591 362948001996 This domain is found in peptide chain release factors; Region: PCRF; smart00937 362948001997 RF-1 domain; Region: RF-1; pfam00472 362948001998 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 362948001999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948002000 S-adenosylmethionine binding site [chemical binding]; other site 362948002001 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 362948002002 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 362948002003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948002004 active site 362948002005 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 362948002006 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 362948002007 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 362948002008 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 362948002009 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 362948002010 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 362948002011 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 362948002012 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 362948002013 beta subunit interaction interface [polypeptide binding]; other site 362948002014 Walker A motif; other site 362948002015 ATP binding site [chemical binding]; other site 362948002016 Walker B motif; other site 362948002017 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 362948002018 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 362948002019 core domain interface [polypeptide binding]; other site 362948002020 delta subunit interface [polypeptide binding]; other site 362948002021 epsilon subunit interface [polypeptide binding]; other site 362948002022 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 362948002023 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 362948002024 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 362948002025 alpha subunit interaction interface [polypeptide binding]; other site 362948002026 Walker A motif; other site 362948002027 ATP binding site [chemical binding]; other site 362948002028 Walker B motif; other site 362948002029 inhibitor binding site; inhibition site 362948002030 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 362948002031 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 362948002032 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 362948002033 gamma subunit interface [polypeptide binding]; other site 362948002034 epsilon subunit interface [polypeptide binding]; other site 362948002035 LBP interface [polypeptide binding]; other site 362948002036 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 362948002037 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 362948002038 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 362948002039 hinge; other site 362948002040 active site 362948002041 rod shape-determining protein MreB; Provisional; Region: PRK13930 362948002042 MreB and similar proteins; Region: MreB_like; cd10225 362948002043 nucleotide binding site [chemical binding]; other site 362948002044 Mg binding site [ion binding]; other site 362948002045 putative protofilament interaction site [polypeptide binding]; other site 362948002046 RodZ interaction site [polypeptide binding]; other site 362948002047 Haemolytic domain; Region: Haemolytic; pfam01809 362948002048 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 362948002049 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 362948002050 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 362948002051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948002052 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948002053 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948002054 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 362948002055 Phosphotransferase enzyme family; Region: APH; pfam01636 362948002056 active site 362948002057 ATP binding site [chemical binding]; other site 362948002058 substrate binding site [chemical binding]; other site 362948002059 Guanylate kinase; Region: Guanylate_kin; pfam00625 362948002060 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 362948002061 catalytic site [active] 362948002062 G-X2-G-X-G-K; other site 362948002063 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 362948002064 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 362948002065 Flavoprotein; Region: Flavoprotein; cl19190 362948002066 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 362948002067 primosome assembly protein PriA; Validated; Region: PRK05580 362948002068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948002069 ATP binding site [chemical binding]; other site 362948002070 putative Mg++ binding site [ion binding]; other site 362948002071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948002072 ATP-binding site [chemical binding]; other site 362948002073 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 362948002074 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 362948002075 putative active site [active] 362948002076 substrate binding site [chemical binding]; other site 362948002077 putative cosubstrate binding site; other site 362948002078 catalytic site [active] 362948002079 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 362948002080 substrate binding site [chemical binding]; other site 362948002081 16S rRNA methyltransferase B; Provisional; Region: PRK14902 362948002082 NusB family; Region: NusB; pfam01029 362948002083 putative RNA binding site [nucleotide binding]; other site 362948002084 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cl19123 362948002085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948002086 S-adenosylmethionine binding site [chemical binding]; other site 362948002087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 362948002088 active site 362948002089 Similar to serine/threonine protein kinase 2.7.1.37); nonfunctional due to truncation 362948002090 GTPase RsgA; Reviewed; Region: PRK00098 362948002091 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 362948002092 RNA binding site [nucleotide binding]; other site 362948002093 homodimer interface [polypeptide binding]; other site 362948002094 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 362948002095 GTPase/Zn-binding domain interface [polypeptide binding]; other site 362948002096 GTP/Mg2+ binding site [chemical binding]; other site 362948002097 G4 box; other site 362948002098 G5 box; other site 362948002099 G1 box; other site 362948002100 Switch I region; other site 362948002101 G2 box; other site 362948002102 G3 box; other site 362948002103 Switch II region; other site 362948002104 Thiamine pyrophosphokinase; Region: TPK; cd07995 362948002105 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 362948002106 active site 362948002107 dimerization interface [polypeptide binding]; other site 362948002108 thiamine binding site [chemical binding]; other site 362948002109 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 362948002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 362948002111 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 362948002112 DAK2 domain; Region: Dak2; pfam02734 362948002113 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 362948002114 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 362948002115 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 362948002116 generic binding surface II; other site 362948002117 ssDNA binding site; other site 362948002118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948002119 ATP binding site [chemical binding]; other site 362948002120 putative Mg++ binding site [ion binding]; other site 362948002121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948002122 nucleotide binding region [chemical binding]; other site 362948002123 ATP-binding site [chemical binding]; other site 362948002124 putative phosphate acyltransferase; Provisional; Region: PRK05331 362948002125 acyl carrier protein; Provisional; Region: acpP; PRK00982 362948002126 ribonuclease III; Reviewed; Region: rnc; PRK00102 362948002127 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 362948002128 dimerization interface [polypeptide binding]; other site 362948002129 active site 362948002130 metal binding site [ion binding]; metal-binding site 362948002131 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 362948002132 dsRNA binding site [nucleotide binding]; other site 362948002133 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 362948002134 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 362948002135 Walker A/P-loop; other site 362948002136 ATP binding site [chemical binding]; other site 362948002137 Q-loop/lid; other site 362948002138 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 362948002139 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 362948002140 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 362948002141 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 362948002142 Q-loop/lid; other site 362948002143 ABC transporter signature motif; other site 362948002144 Walker B; other site 362948002145 D-loop; other site 362948002146 H-loop/switch region; other site 362948002147 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 362948002148 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 362948002149 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 362948002150 P loop; other site 362948002151 GTP binding site [chemical binding]; other site 362948002152 putative DNA-binding protein; Validated; Region: PRK00118 362948002153 signal recognition particle protein; Provisional; Region: PRK10867 362948002154 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 362948002155 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 362948002156 P loop; other site 362948002157 GTP binding site [chemical binding]; other site 362948002158 Signal peptide binding domain; Region: SRP_SPB; pfam02978 362948002159 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 362948002160 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 362948002161 G-X-X-G motif; other site 362948002162 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 362948002163 RimM N-terminal domain; Region: RimM; pfam01782 362948002164 PRC-barrel domain; Region: PRC; pfam05239 362948002165 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 362948002166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948002167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 362948002168 Coenzyme A binding pocket [chemical binding]; other site 362948002169 amino acid transporter; Region: 2A0306; TIGR00909 362948002170 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948002171 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 362948002172 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 362948002173 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 362948002174 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 362948002175 16S/18S rRNA binding site [nucleotide binding]; other site 362948002176 S13e-L30e interaction site [polypeptide binding]; other site 362948002177 25S rRNA binding site [nucleotide binding]; other site 362948002178 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 362948002179 dimer interface [polypeptide binding]; other site 362948002180 active site 362948002181 catalytic residue [active] 362948002182 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 362948002183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 362948002184 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 362948002185 Outer membrane lipoprotein; Region: YfiO; pfam13525 362948002186 elongation factor Tu; Reviewed; Region: PRK00049 362948002187 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 362948002188 G1 box; other site 362948002189 GEF interaction site [polypeptide binding]; other site 362948002190 GTP/Mg2+ binding site [chemical binding]; other site 362948002191 Switch I region; other site 362948002192 G2 box; other site 362948002193 G3 box; other site 362948002194 Switch II region; other site 362948002195 G4 box; other site 362948002196 G5 box; other site 362948002197 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 362948002198 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 362948002199 Antibiotic Binding Site [chemical binding]; other site 362948002200 trigger factor; Provisional; Region: tig; PRK01490 362948002201 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 362948002202 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362948002203 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 362948002204 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 362948002205 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 362948002206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948002207 Walker A motif; other site 362948002208 ATP binding site [chemical binding]; other site 362948002209 Walker B motif; other site 362948002210 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362948002211 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 362948002212 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 362948002213 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 362948002214 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 362948002215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 362948002216 Domain of unknown function (DUF4453); Region: DUF4453; pfam14627 362948002217 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 362948002218 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 362948002219 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 362948002220 active site 362948002221 catalytic residues [active] 362948002222 metal binding site [ion binding]; metal-binding site 362948002223 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 362948002224 substrate binding site [chemical binding]; other site 362948002225 hypothetical protein; Provisional; Region: PRK04387 362948002226 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 362948002227 active site 362948002228 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 362948002229 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 362948002230 G1 box; other site 362948002231 putative GEF interaction site [polypeptide binding]; other site 362948002232 GTP/Mg2+ binding site [chemical binding]; other site 362948002233 Switch I region; other site 362948002234 G2 box; other site 362948002235 G3 box; other site 362948002236 Switch II region; other site 362948002237 G4 box; other site 362948002238 G5 box; other site 362948002239 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 362948002240 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 362948002241 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 362948002242 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362948002243 active pocket/dimerization site; other site 362948002244 active site 362948002245 phosphorylation site [posttranslational modification] 362948002246 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362948002247 active site 362948002248 phosphorylation site [posttranslational modification] 362948002249 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 362948002250 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 362948002251 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 362948002252 pyruvate carboxylase; Reviewed; Region: PRK12999 362948002253 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362948002254 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948002255 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 362948002256 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 362948002257 active site 362948002258 catalytic residues [active] 362948002259 metal binding site [ion binding]; metal-binding site 362948002260 homodimer binding site [polypeptide binding]; other site 362948002261 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 362948002262 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 362948002263 carboxyltransferase (CT) interaction site; other site 362948002264 biotinylation site [posttranslational modification]; other site 362948002265 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 362948002266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948002267 S-adenosylmethionine binding site [chemical binding]; other site 362948002268 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 362948002269 active site 362948002270 nucleotide binding site [chemical binding]; other site 362948002271 HIGH motif; other site 362948002272 KMSKS motif; other site 362948002273 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 362948002274 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362948002275 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 362948002276 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 362948002277 ATP binding site [chemical binding]; other site 362948002278 active site 362948002279 substrate binding site [chemical binding]; other site 362948002280 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 362948002281 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 362948002282 putative active site [active] 362948002283 catalytic triad [active] 362948002284 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 362948002285 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 362948002286 dimerization interface [polypeptide binding]; other site 362948002287 ATP binding site [chemical binding]; other site 362948002288 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 362948002289 dimerization interface [polypeptide binding]; other site 362948002290 ATP binding site [chemical binding]; other site 362948002291 amidophosphoribosyltransferase; Provisional; Region: PRK07272 362948002292 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 362948002293 active site 362948002294 tetramer interface [polypeptide binding]; other site 362948002295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948002296 active site 362948002297 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 362948002298 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 362948002299 dimerization interface [polypeptide binding]; other site 362948002300 putative ATP binding site [chemical binding]; other site 362948002301 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 362948002302 active site 362948002303 substrate binding site [chemical binding]; other site 362948002304 cosubstrate binding site; other site 362948002305 catalytic site [active] 362948002306 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 362948002307 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 362948002308 purine monophosphate binding site [chemical binding]; other site 362948002309 dimer interface [polypeptide binding]; other site 362948002310 putative catalytic residues [active] 362948002311 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 362948002312 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 362948002313 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 362948002314 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948002315 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 362948002316 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 362948002317 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 362948002318 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 362948002319 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 362948002320 putative active site [active] 362948002321 catalytic site [active] 362948002322 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 362948002323 putative active site [active] 362948002324 catalytic site [active] 362948002325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948002326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948002327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 362948002328 dimerization interface [polypeptide binding]; other site 362948002329 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 362948002330 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948002332 active site 362948002333 motif I; other site 362948002334 motif II; other site 362948002335 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 362948002336 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 362948002337 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 362948002338 active site 362948002339 HIGH motif; other site 362948002340 KMSK motif region; other site 362948002341 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 362948002342 tRNA binding surface [nucleotide binding]; other site 362948002343 anticodon binding site; other site 362948002344 SLBB domain; Region: SLBB; pfam10531 362948002345 comEA protein; Region: comE; TIGR01259 362948002346 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 362948002347 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 362948002348 catalytic motif [active] 362948002349 Zn binding site [ion binding]; other site 362948002350 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 362948002351 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 362948002352 Competence protein; Region: Competence; pfam03772 362948002353 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 362948002354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 362948002355 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 362948002356 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 362948002357 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 362948002358 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 362948002359 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 362948002360 homotetramer interface [polypeptide binding]; other site 362948002361 FMN binding site [chemical binding]; other site 362948002362 homodimer contacts [polypeptide binding]; other site 362948002363 putative active site [active] 362948002364 putative substrate binding site [chemical binding]; other site 362948002365 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 362948002366 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362948002367 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 362948002368 diphosphomevalonate decarboxylase; Region: PLN02407 362948002369 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 362948002370 mevalonate kinase; Region: mevalon_kin; TIGR00549 362948002371 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362948002372 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 362948002373 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 362948002374 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 362948002375 active site 362948002376 catalytic site [active] 362948002377 substrate binding site [chemical binding]; other site 362948002378 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 362948002379 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 362948002380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 362948002381 aspartate aminotransferase; Provisional; Region: PRK05764 362948002382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948002383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948002384 homodimer interface [polypeptide binding]; other site 362948002385 catalytic residue [active] 362948002386 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 362948002387 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 362948002388 Dimer interface [polypeptide binding]; other site 362948002389 anticodon binding site; other site 362948002390 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 362948002391 homodimer interface [polypeptide binding]; other site 362948002392 motif 1; other site 362948002393 motif 2; other site 362948002394 active site 362948002395 motif 3; other site 362948002396 Helix-turn-helix domain; Region: HTH_36; pfam13730 362948002397 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 362948002398 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 362948002399 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 362948002400 minor groove reading motif; other site 362948002401 helix-hairpin-helix signature motif; other site 362948002402 substrate binding pocket [chemical binding]; other site 362948002403 active site 362948002404 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 362948002405 methionine sulfoxide reductase A; Provisional; Region: PRK14054 362948002406 Uncharacterized conserved protein [Function unknown]; Region: COG1284 362948002407 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948002408 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948002409 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 362948002410 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 362948002411 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948002412 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 362948002413 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362948002414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362948002415 active site 362948002416 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 362948002417 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 362948002418 Yqey-like protein; Region: YqeY; pfam09424 362948002419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362948002420 Uncharacterized conserved protein [Function unknown]; Region: COG1284 362948002421 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948002422 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948002423 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 362948002424 dihydrodipicolinate reductase; Provisional; Region: PRK00048 362948002425 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 362948002426 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 362948002427 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 362948002428 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 362948002429 active site 362948002430 NTP binding site [chemical binding]; other site 362948002431 metal binding triad [ion binding]; metal-binding site 362948002432 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 362948002433 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 362948002434 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 362948002435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948002436 ABC transporter; Region: ABC_tran_2; pfam12848 362948002437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948002438 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 362948002439 dimerization interface [polypeptide binding]; other site 362948002440 active site 362948002441 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 362948002442 folate binding site [chemical binding]; other site 362948002443 NADP+ binding site [chemical binding]; other site 362948002444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948002445 active site 362948002446 catalytic tetrad [active] 362948002447 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 362948002448 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 362948002449 DNA binding residues [nucleotide binding] 362948002450 putative dimer interface [polypeptide binding]; other site 362948002451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948002452 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 362948002453 active site 362948002454 catalytic tetrad [active] 362948002455 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 362948002456 active site 362948002457 catalytic triad [active] 362948002458 oxyanion hole [active] 362948002459 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 362948002460 hypothetical protein; Provisional; Region: PRK13672 362948002461 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 362948002462 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 362948002463 GTP/Mg2+ binding site [chemical binding]; other site 362948002464 G4 box; other site 362948002465 G5 box; other site 362948002466 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362948002467 G1 box; other site 362948002468 G1 box; other site 362948002469 GTP/Mg2+ binding site [chemical binding]; other site 362948002470 Switch I region; other site 362948002471 G2 box; other site 362948002472 G2 box; other site 362948002473 Switch I region; other site 362948002474 G3 box; other site 362948002475 G3 box; other site 362948002476 Switch II region; other site 362948002477 Switch II region; other site 362948002478 G4 box; other site 362948002479 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 362948002480 RNA/DNA hybrid binding site [nucleotide binding]; other site 362948002481 active site 362948002482 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 362948002483 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 362948002484 DNA topoisomerase I; Validated; Region: PRK05582 362948002485 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 362948002486 active site 362948002487 interdomain interaction site; other site 362948002488 putative metal-binding site [ion binding]; other site 362948002489 nucleotide binding site [chemical binding]; other site 362948002490 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 362948002491 domain I; other site 362948002492 DNA binding groove [nucleotide binding] 362948002493 phosphate binding site [ion binding]; other site 362948002494 domain II; other site 362948002495 domain III; other site 362948002496 nucleotide binding site [chemical binding]; other site 362948002497 catalytic site [active] 362948002498 domain IV; other site 362948002499 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362948002500 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362948002501 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362948002502 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 362948002503 Glucose inhibited division protein A; Region: GIDA; pfam01134 362948002504 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 362948002505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948002507 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362948002508 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362948002509 Walker A/P-loop; other site 362948002510 ATP binding site [chemical binding]; other site 362948002511 Q-loop/lid; other site 362948002512 ABC transporter signature motif; other site 362948002513 Walker B; other site 362948002514 D-loop; other site 362948002515 H-loop/switch region; other site 362948002516 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 362948002517 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 362948002518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948002519 catalytic core [active] 362948002520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002521 TPR motif; other site 362948002522 Tetratricopeptide repeat; Region: TPR_12; pfam13424 362948002523 binding surface 362948002524 Tetratricopeptide repeat; Region: TPR_12; pfam13424 362948002525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002526 TPR motif; other site 362948002527 binding surface 362948002528 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 362948002529 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 362948002530 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 362948002531 AAA domain; Region: AAA_30; pfam13604 362948002532 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948002533 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 362948002534 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 362948002535 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948002536 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948002537 Int/Topo IB signature motif; other site 362948002538 Transposase IS200 like; Region: Y1_Tnp; pfam01797 362948002539 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 362948002540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 362948002541 Probable transposase; Region: OrfB_IS605; pfam01385 362948002542 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 362948002543 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 362948002544 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 362948002545 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 362948002546 Domain of unknown function (DUF955); Region: DUF955; cl01076 362948002547 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948002548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948002549 non-specific DNA binding site [nucleotide binding]; other site 362948002550 salt bridge; other site 362948002551 sequence-specific DNA binding site [nucleotide binding]; other site 362948002552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 362948002553 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 362948002554 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 362948002555 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 362948002556 Domain of unknown function (DUF771); Region: DUF771; pfam05595 362948002557 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 362948002558 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 362948002559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948002560 ATP binding site [chemical binding]; other site 362948002561 putative Mg++ binding site [ion binding]; other site 362948002562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948002563 nucleotide binding region [chemical binding]; other site 362948002564 ATP-binding site [chemical binding]; other site 362948002565 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 362948002566 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 362948002567 Protein of unknown function (DUF669); Region: DUF669; pfam05037 362948002568 DNA polymerase type-B family; Region: POLBc; smart00486 362948002569 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 362948002570 active site 362948002571 metal-binding site 362948002572 D5 N terminal like; Region: D5_N; smart00885 362948002573 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 362948002574 HNH endonuclease; Region: HNH_3; pfam13392 362948002575 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948002576 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948002577 Int/Topo IB signature motif; other site 362948002578 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 362948002579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 362948002580 active site 362948002581 Phage terminase, small subunit; Region: Terminase_4; pfam05119 362948002582 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 362948002583 Phage Terminase; Region: Terminase_1; cl19862 362948002584 Phage portal protein; Region: Phage_portal; pfam04860 362948002585 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 362948002586 oligomer interface [polypeptide binding]; other site 362948002587 active site residues [active] 362948002588 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 362948002589 Phage capsid family; Region: Phage_capsid; pfam05065 362948002590 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 362948002591 oligomerization interface [polypeptide binding]; other site 362948002592 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 362948002593 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 362948002594 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 362948002595 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 362948002596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 362948002597 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 362948002598 catalytic residue [active] 362948002599 Phage tail protein; Region: Sipho_tail; pfam05709 362948002600 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 362948002601 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 362948002602 Peptidase family M23; Region: Peptidase_M23; pfam01551 362948002603 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 362948002604 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 362948002605 active site 362948002606 competence damage-inducible protein A; Provisional; Region: PRK00549 362948002607 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 362948002608 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 362948002609 HemX; Region: HemX; cl19375 362948002610 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 362948002611 active site 362948002612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948002613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948002614 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 362948002615 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 362948002616 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 362948002617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948002618 Zn2+ binding site [ion binding]; other site 362948002619 Mg2+ binding site [ion binding]; other site 362948002620 Predicted transcriptional regulators [Transcription]; Region: COG1733 362948002621 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948002622 dimerization interface [polypeptide binding]; other site 362948002623 putative Zn2+ binding site [ion binding]; other site 362948002624 putative DNA binding site [nucleotide binding]; other site 362948002625 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 362948002626 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 362948002627 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 362948002628 dimer interface [polypeptide binding]; other site 362948002629 motif 1; other site 362948002630 active site 362948002631 motif 2; other site 362948002632 motif 3; other site 362948002633 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 362948002634 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 362948002635 putative tRNA-binding site [nucleotide binding]; other site 362948002636 B3/4 domain; Region: B3_4; pfam03483 362948002637 tRNA synthetase B5 domain; Region: B5; smart00874 362948002638 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 362948002639 dimer interface [polypeptide binding]; other site 362948002640 motif 1; other site 362948002641 motif 3; other site 362948002642 motif 2; other site 362948002643 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 362948002644 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 362948002645 dimerization interface [polypeptide binding]; other site 362948002646 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 362948002647 ATP-binding site [chemical binding]; other site 362948002648 Sugar specificity; other site 362948002649 Pyrimidine base specificity; other site 362948002650 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 362948002651 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 362948002652 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 362948002653 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 362948002654 active site 362948002655 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 362948002656 Similar to ribosomal protein L11 methyltransferase nonfunctional due to deletion of 60 bp 362948002657 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 362948002658 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 362948002659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948002660 Zn2+ binding site [ion binding]; other site 362948002661 Mg2+ binding site [ion binding]; other site 362948002662 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 362948002663 synthetase active site [active] 362948002664 NTP binding site [chemical binding]; other site 362948002665 metal binding site [ion binding]; metal-binding site 362948002666 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 362948002667 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 362948002668 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 362948002669 putative active site [active] 362948002670 dimerization interface [polypeptide binding]; other site 362948002671 putative tRNAtyr binding site [nucleotide binding]; other site 362948002672 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 362948002673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948002674 motif II; other site 362948002675 lipoprotein signal peptidase; Provisional; Region: PRK14797 362948002676 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 362948002677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948002678 RNA binding surface [nucleotide binding]; other site 362948002679 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362948002680 active site 362948002681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948002682 active site 362948002683 Sulfate transporter family; Region: Sulfate_transp; cl19250 362948002684 uracil-xanthine permease; Region: ncs2; TIGR00801 362948002685 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 362948002686 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 362948002687 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 362948002688 catalytic site [active] 362948002689 subunit interface [polypeptide binding]; other site 362948002690 Similar to carbamoyl-phosphate synthase large chain; nonfunctional due to truncation 362948002691 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 362948002692 active site 362948002693 dimer interface [polypeptide binding]; other site 362948002694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948002695 active site 362948002696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948002697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948002698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 362948002699 dimerization interface [polypeptide binding]; other site 362948002700 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 362948002701 DHH family; Region: DHH; pfam01368 362948002702 DHHA2 domain; Region: DHHA2; pfam02833 362948002703 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362948002704 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362948002705 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362948002706 aminotransferase A; Validated; Region: PRK07683 362948002707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948002708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948002709 homodimer interface [polypeptide binding]; other site 362948002710 catalytic residue [active] 362948002711 glutamate racemase; Provisional; Region: PRK00865 362948002712 cell division protein GpsB; Provisional; Region: PRK14127 362948002713 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 362948002714 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 362948002715 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 362948002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 362948002717 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 362948002718 RNA/DNA hybrid binding site [nucleotide binding]; other site 362948002719 active site 362948002720 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 362948002721 Potassium binding sites [ion binding]; other site 362948002722 Cesium cation binding sites [ion binding]; other site 362948002723 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 362948002724 Similar to transporter, MFS superfamily; nonfunctional due to frameshift; Nonfunctional due to frameshift 362948002725 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 362948002726 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 362948002727 peptidase T-like protein; Region: PepT-like; TIGR01883 362948002728 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 362948002729 metal binding site [ion binding]; metal-binding site 362948002730 dimer interface [polypeptide binding]; other site 362948002731 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 362948002732 active site 362948002733 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 362948002734 EamA-like transporter family; Region: EamA; pfam00892 362948002735 EamA-like transporter family; Region: EamA; pfam00892 362948002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002737 TPR motif; other site 362948002738 binding surface 362948002739 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 362948002740 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002741 binding surface 362948002742 TPR motif; other site 362948002743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002744 TPR motif; other site 362948002745 binding surface 362948002746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362948002747 binding surface 362948002748 TPR motif; other site 362948002749 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 362948002750 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 362948002751 dimer interface [polypeptide binding]; other site 362948002752 motif 1; other site 362948002753 active site 362948002754 motif 2; other site 362948002755 motif 3; other site 362948002756 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 362948002757 anticodon binding site; other site 362948002758 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 362948002759 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 362948002760 dimer interface [polypeptide binding]; other site 362948002761 anticodon binding site; other site 362948002762 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 362948002763 homodimer interface [polypeptide binding]; other site 362948002764 motif 1; other site 362948002765 active site 362948002766 motif 2; other site 362948002767 GAD domain; Region: GAD; pfam02938 362948002768 motif 3; other site 362948002769 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 362948002770 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 362948002771 Cl binding site [ion binding]; other site 362948002772 oligomer interface [polypeptide binding]; other site 362948002773 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 362948002774 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 362948002775 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 362948002776 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 362948002777 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 362948002778 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 362948002779 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 362948002780 dimer interface [polypeptide binding]; other site 362948002781 ADP-ribose binding site [chemical binding]; other site 362948002782 active site 362948002783 nudix motif; other site 362948002784 metal binding site [ion binding]; metal-binding site 362948002785 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 362948002786 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 362948002787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948002788 catalytic residue [active] 362948002789 Putative amino acid metabolizm; Region: DUF1831; pfam08866 362948002790 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 362948002791 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 362948002792 Ligand Binding Site [chemical binding]; other site 362948002793 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 362948002794 Clp amino terminal domain; Region: Clp_N; pfam02861 362948002795 Clp amino terminal domain; Region: Clp_N; pfam02861 362948002796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948002797 Walker A motif; other site 362948002798 ATP binding site [chemical binding]; other site 362948002799 Walker B motif; other site 362948002800 arginine finger; other site 362948002801 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 362948002802 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 362948002803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948002804 Walker A motif; other site 362948002805 ATP binding site [chemical binding]; other site 362948002806 Walker B motif; other site 362948002807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362948002808 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 362948002809 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 362948002810 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 362948002811 active site 362948002812 PHP Thumb interface [polypeptide binding]; other site 362948002813 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 362948002814 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 362948002815 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 362948002816 generic binding surface I; other site 362948002817 generic binding surface II; other site 362948002818 6-phosphofructokinase; Provisional; Region: PRK03202 362948002819 active site 362948002820 ADP/pyrophosphate binding site [chemical binding]; other site 362948002821 dimerization interface [polypeptide binding]; other site 362948002822 allosteric effector site; other site 362948002823 fructose-1,6-bisphosphate binding site; other site 362948002824 pyruvate kinase; Provisional; Region: PRK06354 362948002825 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 362948002826 domain interfaces; other site 362948002827 active site 362948002828 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 362948002829 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 362948002830 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 362948002831 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 362948002832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948002833 ATP binding site [chemical binding]; other site 362948002834 Mg2+ binding site [ion binding]; other site 362948002835 G-X-G motif; other site 362948002836 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 362948002837 anchoring element; other site 362948002838 dimer interface [polypeptide binding]; other site 362948002839 ATP binding site [chemical binding]; other site 362948002840 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 362948002841 active site 362948002842 metal binding site [ion binding]; metal-binding site 362948002843 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 362948002844 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 362948002845 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 362948002846 CAP-like domain; other site 362948002847 active site 362948002848 primary dimer interface [polypeptide binding]; other site 362948002849 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 362948002850 Domain of unknown function (DUF814); Region: DUF814; pfam05670 362948002851 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948002852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 362948002853 EDD domain protein, DegV family; Region: DegV; TIGR00762 362948002854 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 362948002855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 362948002856 Catalytic site [active] 362948002857 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 362948002858 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 362948002859 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 362948002860 dimer interface [polypeptide binding]; other site 362948002861 active site 362948002862 glycine-pyridoxal phosphate binding site [chemical binding]; other site 362948002863 folate binding site [chemical binding]; other site 362948002864 putative phosphoesterase; Region: acc_ester; TIGR03729 362948002865 EamA-like transporter family; Region: EamA; pfam00892 362948002866 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 362948002867 EamA-like transporter family; Region: EamA; pfam00892 362948002868 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 362948002869 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 362948002870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948002871 Walker A/P-loop; other site 362948002872 ATP binding site [chemical binding]; other site 362948002873 Q-loop/lid; other site 362948002874 ABC transporter signature motif; other site 362948002875 Walker B; other site 362948002876 D-loop; other site 362948002877 H-loop/switch region; other site 362948002878 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 362948002879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948002880 Coenzyme A binding pocket [chemical binding]; other site 362948002881 histone-like DNA-binding protein HU; Region: HU; cd13831 362948002882 dimer interface [polypeptide binding]; other site 362948002883 DNA binding site [nucleotide binding] 362948002884 GTP-binding protein Der; Reviewed; Region: PRK00093 362948002885 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 362948002886 G1 box; other site 362948002887 GTP/Mg2+ binding site [chemical binding]; other site 362948002888 Switch I region; other site 362948002889 G2 box; other site 362948002890 Switch II region; other site 362948002891 G3 box; other site 362948002892 G4 box; other site 362948002893 G5 box; other site 362948002894 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 362948002895 G1 box; other site 362948002896 GTP/Mg2+ binding site [chemical binding]; other site 362948002897 Switch I region; other site 362948002898 G2 box; other site 362948002899 G3 box; other site 362948002900 Switch II region; other site 362948002901 G4 box; other site 362948002902 G5 box; other site 362948002903 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 362948002904 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 362948002905 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362948002906 RNA binding site [nucleotide binding]; other site 362948002907 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 362948002908 RNA binding site [nucleotide binding]; other site 362948002909 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 362948002910 RNA binding site [nucleotide binding]; other site 362948002911 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362948002912 RNA binding site [nucleotide binding]; other site 362948002913 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 362948002914 active site 362948002915 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 362948002916 DltD N-terminal region; Region: DltD_N; pfam04915 362948002917 DltD central region; Region: DltD_M; pfam04918 362948002918 DltD C-terminal region; Region: DltD_C; pfam04914 362948002919 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 362948002920 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 362948002921 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 362948002922 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 362948002923 acyl-activating enzyme (AAE) consensus motif; other site 362948002924 AMP binding site [chemical binding]; other site 362948002925 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 362948002926 Recombination protein O N terminal; Region: RecO_N; pfam11967 362948002927 DNA repair protein RecO; Region: reco; TIGR00613 362948002928 Recombination protein O C terminal; Region: RecO_C; pfam02565 362948002929 GTPase Era; Reviewed; Region: era; PRK00089 362948002930 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 362948002931 G1 box; other site 362948002932 GTP/Mg2+ binding site [chemical binding]; other site 362948002933 Switch I region; other site 362948002934 G2 box; other site 362948002935 Switch II region; other site 362948002936 G3 box; other site 362948002937 G4 box; other site 362948002938 G5 box; other site 362948002939 KH domain; Region: KH_2; pfam07650 362948002940 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 362948002941 trimer interface [polypeptide binding]; other site 362948002942 putative active site [active] 362948002943 Zn binding site [ion binding]; other site 362948002944 metal-binding heat shock protein; Provisional; Region: PRK00016 362948002945 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 362948002946 PhoH-like protein; Region: PhoH; pfam02562 362948002947 Bacterial SH3 domain; Region: SH3_3; pfam08239 362948002948 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 362948002949 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 362948002950 active site 362948002951 metal binding site [ion binding]; metal-binding site 362948002952 cytidylate kinase; Provisional; Region: cmk; PRK00023 362948002953 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 362948002954 CMP-binding site; other site 362948002955 The sites determining sugar specificity; other site 362948002956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948002957 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 362948002958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948002959 ATP binding site [chemical binding]; other site 362948002960 putative Mg++ binding site [ion binding]; other site 362948002961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948002962 nucleotide binding region [chemical binding]; other site 362948002963 ATP-binding site [chemical binding]; other site 362948002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 362948002965 Helix-turn-helix domain; Region: HTH_40; pfam14493 362948002966 manganese transport protein MntH; Reviewed; Region: PRK00701 362948002967 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 362948002968 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 362948002969 Similar to glycosyltransferase; nonfunctional due to frameshift 362948002970 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 362948002971 conserved hypothetical integral membrane protein; Region: TIGR03766 362948002972 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 362948002973 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 362948002974 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 362948002975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362948002976 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 362948002977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362948002978 DNA binding residues [nucleotide binding] 362948002979 DNA primase; Validated; Region: dnaG; PRK05667 362948002980 CHC2 zinc finger; Region: zf-CHC2; cl17510 362948002981 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 362948002982 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 362948002983 active site 362948002984 metal binding site [ion binding]; metal-binding site 362948002985 interdomain interaction site; other site 362948002986 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 362948002987 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 362948002988 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 362948002989 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 362948002990 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 362948002991 dimer interface [polypeptide binding]; other site 362948002992 motif 1; other site 362948002993 active site 362948002994 motif 2; other site 362948002995 motif 3; other site 362948002996 Putative lysophospholipase; Region: Hydrolase_4; cl19140 362948002997 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 362948002998 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 362948002999 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003000 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003001 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 362948003002 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003003 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003004 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948003005 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948003006 Int/Topo IB signature motif; other site 362948003007 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003008 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 362948003009 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948003010 HsdM N-terminal domain; Region: HsdM_N; pfam12161 362948003011 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 362948003012 Methyltransferase domain; Region: Methyltransf_26; pfam13659 362948003013 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 362948003014 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 362948003015 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 362948003016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948003017 ATP binding site [chemical binding]; other site 362948003018 putative Mg++ binding site [ion binding]; other site 362948003019 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 362948003020 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 362948003021 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 362948003022 nudix motif; other site 362948003023 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362948003024 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 362948003025 active site 362948003026 maltose O-acetyltransferase; Provisional; Region: PRK10092 362948003027 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 362948003028 active site 362948003029 substrate binding site [chemical binding]; other site 362948003030 trimer interface [polypeptide binding]; other site 362948003031 CoA binding site [chemical binding]; other site 362948003032 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 362948003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003034 Coenzyme A binding pocket [chemical binding]; other site 362948003035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948003036 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948003037 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948003038 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 362948003039 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 362948003040 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 362948003041 active site 362948003042 hypothetical protein; Provisional; Region: PRK13660 362948003043 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 362948003044 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 362948003045 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 362948003046 Transglycosylase; Region: Transgly; pfam00912 362948003047 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 362948003048 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 362948003049 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 362948003050 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 362948003051 active site 362948003052 Int/Topo IB signature motif; other site 362948003053 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 362948003054 S1 domain; Region: S1_2; pfam13509 362948003055 Protein of unknown function (DUF441); Region: DUF441; pfam04284 362948003056 Predicted membrane protein [Function unknown]; Region: COG3601 362948003057 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 362948003058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948003059 RNA binding surface [nucleotide binding]; other site 362948003060 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 362948003061 active site 362948003062 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 362948003063 ScpA/B protein; Region: ScpA_ScpB; cl00598 362948003064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 362948003065 Protein of unknown function (DUF805); Region: DUF805; pfam05656 362948003066 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 362948003067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948003068 Walker A motif; other site 362948003069 ATP binding site [chemical binding]; other site 362948003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948003071 Walker B motif; other site 362948003072 arginine finger; other site 362948003073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362948003074 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 362948003075 active site 362948003076 HslU subunit interaction site [polypeptide binding]; other site 362948003077 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362948003078 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 362948003079 active site 362948003080 DNA binding site [nucleotide binding] 362948003081 Int/Topo IB signature motif; other site 362948003082 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 362948003083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948003084 S-adenosylmethionine binding site [chemical binding]; other site 362948003085 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 362948003086 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 362948003087 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 362948003088 Protein of unknown function (DUF464); Region: DUF464; pfam04327 362948003089 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 362948003090 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 362948003091 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 362948003092 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 362948003093 nudix motif; other site 362948003094 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362948003095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948003096 NAD(P) binding site [chemical binding]; other site 362948003097 active site 362948003098 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 362948003099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003100 Coenzyme A binding pocket [chemical binding]; other site 362948003101 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 362948003102 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 362948003103 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 362948003104 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 362948003105 putative NAD(P) binding site [chemical binding]; other site 362948003106 CHY zinc finger; Region: zf-CHY; cl19861 362948003107 Predicted transcriptional regulator [Transcription]; Region: COG1959 362948003108 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 362948003109 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 362948003110 NADP binding site [chemical binding]; other site 362948003111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948003113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003114 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948003115 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 362948003116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 362948003117 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 362948003118 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 362948003119 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362948003120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948003121 NAD(P) binding site [chemical binding]; other site 362948003122 active site 362948003123 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 362948003124 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 362948003125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003126 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948003127 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 362948003128 putative ligand binding site [chemical binding]; other site 362948003129 putative catalytic site [active] 362948003130 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 362948003131 putative ligand binding site [chemical binding]; other site 362948003132 putative catalytic site [active] 362948003133 EpsG family; Region: EpsG; pfam14897 362948003134 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362948003135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362948003136 active site 362948003137 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 362948003138 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 362948003139 Ligand binding site; other site 362948003140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003141 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 362948003142 putative ADP-binding pocket [chemical binding]; other site 362948003143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003144 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 362948003145 putative ADP-binding pocket [chemical binding]; other site 362948003146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003147 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 362948003148 putative ADP-binding pocket [chemical binding]; other site 362948003149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948003150 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 362948003151 putative ADP-binding pocket [chemical binding]; other site 362948003152 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 362948003153 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 362948003154 putative trimer interface [polypeptide binding]; other site 362948003155 putative CoA binding site [chemical binding]; other site 362948003156 Bacterial sugar transferase; Region: Bac_transf; pfam02397 362948003157 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 362948003158 inhibitor-cofactor binding pocket; inhibition site 362948003159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948003160 catalytic residue [active] 362948003161 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 362948003162 CoA binding domain; Region: CoA_binding; cl17356 362948003163 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 362948003164 NAD(P) binding site [chemical binding]; other site 362948003165 homodimer interface [polypeptide binding]; other site 362948003166 substrate binding site [chemical binding]; other site 362948003167 active site 362948003168 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 362948003169 AAA domain; Region: AAA_31; pfam13614 362948003170 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 362948003171 Chain length determinant protein; Region: Wzz; pfam02706 362948003172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 362948003173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003174 Coenzyme A binding pocket [chemical binding]; other site 362948003175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 362948003176 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 362948003177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948003178 S-adenosylmethionine binding site [chemical binding]; other site 362948003179 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 362948003180 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362948003181 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 362948003182 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 362948003183 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948003184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948003185 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 362948003186 active site 362948003187 motif I; other site 362948003188 motif II; other site 362948003189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 362948003190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003191 Coenzyme A binding pocket [chemical binding]; other site 362948003192 diaminopimelate decarboxylase; Region: lysA; TIGR01048 362948003193 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 362948003194 active site 362948003195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362948003196 substrate binding site [chemical binding]; other site 362948003197 catalytic residues [active] 362948003198 dimer interface [polypeptide binding]; other site 362948003199 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 362948003200 active site 1 [active] 362948003201 dimer interface [polypeptide binding]; other site 362948003202 hexamer interface [polypeptide binding]; other site 362948003203 active site 2 [active] 362948003204 Peptidase family C69; Region: Peptidase_C69; pfam03577 362948003205 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362948003206 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 362948003207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362948003208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362948003209 Predicted membrane protein [Function unknown]; Region: COG2364 362948003210 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 362948003211 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 362948003212 Melibiase; Region: Melibiase; pfam02065 362948003213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362948003214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003215 Coenzyme A binding pocket [chemical binding]; other site 362948003216 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 362948003217 PLD-like domain; Region: PLDc_2; pfam13091 362948003218 putative homodimer interface [polypeptide binding]; other site 362948003219 putative active site [active] 362948003220 catalytic site [active] 362948003221 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 362948003222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948003223 ATP binding site [chemical binding]; other site 362948003224 putative Mg++ binding site [ion binding]; other site 362948003225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948003226 nucleotide binding region [chemical binding]; other site 362948003227 ATP-binding site [chemical binding]; other site 362948003228 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 362948003229 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 362948003230 active site 362948003231 8-oxo-dGMP binding site [chemical binding]; other site 362948003232 nudix motif; other site 362948003233 metal binding site [ion binding]; metal-binding site 362948003234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948003235 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948003236 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948003237 EAL domain; Region: EAL; pfam00563 362948003238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362948003239 nucleotidyl binding site; other site 362948003240 metal binding site [ion binding]; metal-binding site 362948003241 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 362948003242 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 362948003243 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 362948003244 DXD motif; other site 362948003245 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 362948003246 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 362948003247 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362948003248 metal binding site [ion binding]; metal-binding site 362948003249 active site 362948003250 I-site; other site 362948003251 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362948003252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 362948003253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948003254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948003255 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 362948003256 putative active site [active] 362948003257 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 362948003258 substrate binding pocket [chemical binding]; other site 362948003259 chain length determination region; other site 362948003260 substrate-Mg2+ binding site; other site 362948003261 catalytic residues [active] 362948003262 aspartate-rich region 1; other site 362948003263 active site lid residues [active] 362948003264 aspartate-rich region 2; other site 362948003265 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 362948003266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948003267 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 362948003268 Walker A/P-loop; other site 362948003269 ATP binding site [chemical binding]; other site 362948003270 Q-loop/lid; other site 362948003271 ABC transporter signature motif; other site 362948003272 Walker B; other site 362948003273 D-loop; other site 362948003274 H-loop/switch region; other site 362948003275 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 362948003276 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948003277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948003278 Walker A/P-loop; other site 362948003279 ATP binding site [chemical binding]; other site 362948003280 Q-loop/lid; other site 362948003281 ABC transporter signature motif; other site 362948003282 Walker B; other site 362948003283 D-loop; other site 362948003284 H-loop/switch region; other site 362948003285 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 362948003286 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 362948003287 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 362948003288 asparagine synthetase A; Reviewed; Region: PRK06462 362948003289 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 362948003290 dimer interface [polypeptide binding]; other site 362948003291 active site 362948003292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948003293 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 362948003294 active site residue [active] 362948003295 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 362948003296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948003297 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 362948003298 active site 362948003299 metal binding site [ion binding]; metal-binding site 362948003300 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 362948003301 nucleotide binding site/active site [active] 362948003302 HIT family signature motif; other site 362948003303 catalytic residue [active] 362948003304 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 362948003305 Uncharacterized conserved protein [Function unknown]; Region: COG1284 362948003306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948003307 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 362948003308 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 362948003309 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 362948003310 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 362948003311 active site 362948003312 HIGH motif; other site 362948003313 KMSKS motif; other site 362948003314 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 362948003315 tRNA binding surface [nucleotide binding]; other site 362948003316 anticodon binding site; other site 362948003317 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 362948003318 DivIVA protein; Region: DivIVA; pfam05103 362948003319 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 362948003320 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 362948003321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948003322 RNA binding surface [nucleotide binding]; other site 362948003323 YGGT family; Region: YGGT; pfam02325 362948003324 Protein of unknown function (DUF552); Region: DUF552; pfam04472 362948003325 cell division protein FtsZ; Validated; Region: PRK09330 362948003326 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 362948003327 nucleotide binding site [chemical binding]; other site 362948003328 SulA interaction site; other site 362948003329 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 362948003330 Cell division protein FtsA; Region: FtsA; smart00842 362948003331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362948003332 nucleotide binding site [chemical binding]; other site 362948003333 Cell division protein FtsA; Region: FtsA; pfam14450 362948003334 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 362948003335 Cell division protein FtsQ; Region: FtsQ; pfam03799 362948003336 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 362948003337 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 362948003338 active site 362948003339 homodimer interface [polypeptide binding]; other site 362948003340 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 362948003341 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 362948003342 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948003343 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362948003344 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 362948003345 Mg++ binding site [ion binding]; other site 362948003346 putative catalytic motif [active] 362948003347 putative substrate binding site [chemical binding]; other site 362948003348 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 362948003349 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 362948003350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 362948003351 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 362948003352 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 362948003353 Cell division protein FtsL; Region: FtsL; cl11433 362948003354 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 362948003355 cell division protein MraZ; Reviewed; Region: PRK00326 362948003356 MraZ protein; Region: MraZ; pfam02381 362948003357 MraZ protein; Region: MraZ; pfam02381 362948003358 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 362948003359 aspartate kinase I; Reviewed; Region: PRK08210 362948003360 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 362948003361 nucleotide binding site [chemical binding]; other site 362948003362 substrate binding site [chemical binding]; other site 362948003363 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 362948003364 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 362948003365 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 362948003366 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 362948003367 Putative lysophospholipase; Region: Hydrolase_4; cl19140 362948003368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948003369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948003370 substrate binding pocket [chemical binding]; other site 362948003371 membrane-bound complex binding site; other site 362948003372 hinge residues; other site 362948003373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948003375 Walker A/P-loop; other site 362948003376 ATP binding site [chemical binding]; other site 362948003377 Q-loop/lid; other site 362948003378 ABC transporter signature motif; other site 362948003379 Walker B; other site 362948003380 D-loop; other site 362948003381 H-loop/switch region; other site 362948003382 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948003383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948003384 dimer interface [polypeptide binding]; other site 362948003385 conserved gate region; other site 362948003386 putative PBP binding loops; other site 362948003387 ABC-ATPase subunit interface; other site 362948003388 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 362948003389 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 362948003390 P-loop; other site 362948003391 ADP binding residues [chemical binding]; other site 362948003392 Switch I; other site 362948003393 Switch II; other site 362948003394 septum formation inhibitor; Reviewed; Region: minC; PRK00513 362948003395 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 362948003396 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 362948003397 rod shape-determining protein MreC; Provisional; Region: PRK13922 362948003398 rod shape-determining protein MreB; Provisional; Region: PRK13927 362948003399 MreB and similar proteins; Region: MreB_like; cd10225 362948003400 nucleotide binding site [chemical binding]; other site 362948003401 Mg binding site [ion binding]; other site 362948003402 putative protofilament interaction site [polypeptide binding]; other site 362948003403 RodZ interaction site [polypeptide binding]; other site 362948003404 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362948003405 DNA-binding site [nucleotide binding]; DNA binding site 362948003406 RNA-binding motif; other site 362948003407 hypothetical protein; Reviewed; Region: PRK00024 362948003408 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362948003409 MPN+ (JAMM) motif; other site 362948003410 Zinc-binding site [ion binding]; other site 362948003411 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 362948003412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362948003413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362948003414 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 362948003415 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 362948003416 active site 362948003417 HIGH motif; other site 362948003418 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 362948003419 KMSKS motif; other site 362948003420 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 362948003421 tRNA binding surface [nucleotide binding]; other site 362948003422 anticodon binding site; other site 362948003423 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 362948003424 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 362948003425 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 362948003426 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 362948003427 Ligand Binding Site [chemical binding]; other site 362948003428 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 362948003429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948003430 catalytic residue [active] 362948003431 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 362948003432 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 362948003433 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 362948003434 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 362948003435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948003436 RNA binding surface [nucleotide binding]; other site 362948003437 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 362948003438 recombination factor protein RarA; Reviewed; Region: PRK13342 362948003439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948003440 Walker A motif; other site 362948003441 ATP binding site [chemical binding]; other site 362948003442 Walker B motif; other site 362948003443 arginine finger; other site 362948003444 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 362948003445 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362948003446 Ligand Binding Site [chemical binding]; other site 362948003447 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 362948003448 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 362948003449 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 362948003450 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 362948003451 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 362948003452 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 362948003453 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 362948003454 active site 362948003455 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 362948003456 possible sortase recognition-binding site 362948003457 Predicted membrane protein [Function unknown]; Region: COG2323 362948003458 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 362948003459 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 362948003460 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 362948003461 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 362948003462 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 362948003463 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948003464 active site 362948003465 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 362948003466 DHH family; Region: DHH; pfam01368 362948003467 DHHA1 domain; Region: DHHA1; pfam02272 362948003468 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 362948003469 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 362948003470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948003471 NAD(P) binding site [chemical binding]; other site 362948003472 active site 362948003473 ribonuclease Z; Region: RNase_Z; TIGR02651 362948003474 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 362948003475 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 362948003476 catalytic triad [active] 362948003477 catalytic triad [active] 362948003478 oxyanion hole [active] 362948003479 GTPase CgtA; Reviewed; Region: obgE; PRK12297 362948003480 GTP1/OBG; Region: GTP1_OBG; pfam01018 362948003481 Obg GTPase; Region: Obg; cd01898 362948003482 G1 box; other site 362948003483 GTP/Mg2+ binding site [chemical binding]; other site 362948003484 Switch I region; other site 362948003485 G2 box; other site 362948003486 G3 box; other site 362948003487 Switch II region; other site 362948003488 G4 box; other site 362948003489 G5 box; other site 362948003490 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 362948003491 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 362948003492 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 362948003493 GIY-YIG motif/motif A; other site 362948003494 active site 362948003495 catalytic site [active] 362948003496 putative DNA binding site [nucleotide binding]; other site 362948003497 metal binding site [ion binding]; metal-binding site 362948003498 UvrB/uvrC motif; Region: UVR; pfam02151 362948003499 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 362948003500 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 362948003501 DNA binding site [nucleotide binding] 362948003502 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 362948003503 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 362948003504 putative ligand binding site [chemical binding]; other site 362948003505 putative NAD binding site [chemical binding]; other site 362948003506 catalytic site [active] 362948003507 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 362948003508 active site 362948003509 metal binding site [ion binding]; metal-binding site 362948003510 homotetramer interface [polypeptide binding]; other site 362948003511 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 362948003512 active site 362948003513 dimerization interface [polypeptide binding]; other site 362948003514 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 362948003515 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362948003516 catalytic residues [active] 362948003517 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 362948003518 MutS domain III; Region: MutS_III; pfam05192 362948003519 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 362948003520 Walker A/P-loop; other site 362948003521 ATP binding site [chemical binding]; other site 362948003522 Q-loop/lid; other site 362948003523 ABC transporter signature motif; other site 362948003524 Walker B; other site 362948003525 D-loop; other site 362948003526 H-loop/switch region; other site 362948003527 Smr domain; Region: Smr; pfam01713 362948003528 Colicin V production protein; Region: Colicin_V; pfam02674 362948003529 Cell division protein ZapA; Region: ZapA; pfam05164 362948003530 hypothetical protein; Provisional; Region: PRK13678 362948003531 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 362948003532 hypothetical protein; Provisional; Region: PRK05473 362948003533 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 362948003534 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 362948003535 motif 1; other site 362948003536 active site 362948003537 motif 2; other site 362948003538 motif 3; other site 362948003539 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 362948003540 DHHA1 domain; Region: DHHA1; pfam02272 362948003541 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 362948003542 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362948003543 ATP binding site [chemical binding]; other site 362948003544 Mg++ binding site [ion binding]; other site 362948003545 motif III; other site 362948003546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948003547 nucleotide binding region [chemical binding]; other site 362948003548 ATP-binding site [chemical binding]; other site 362948003549 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 362948003550 DHH family; Region: DHH; pfam01368 362948003551 DHHA1 domain; Region: DHHA1; pfam02272 362948003552 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 362948003553 Uncharacterized conserved protein [Function unknown]; Region: COG1556 362948003554 HsdM N-terminal domain; Region: HsdM_N; pfam12161 362948003555 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 362948003556 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 362948003557 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 362948003558 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 362948003559 Cysteine-rich domain; Region: CCG; pfam02754 362948003560 Cysteine-rich domain; Region: CCG; pfam02754 362948003561 amino acid transporter; Region: 2A0306; TIGR00909 362948003562 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948003563 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 362948003564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362948003565 Ligand Binding Site [chemical binding]; other site 362948003566 Preprotein translocase subunit; Region: YajC; pfam02699 362948003567 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 362948003568 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 362948003569 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 362948003570 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 362948003571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948003572 Walker A motif; other site 362948003573 ATP binding site [chemical binding]; other site 362948003574 Walker B motif; other site 362948003575 arginine finger; other site 362948003576 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 362948003577 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 362948003578 RuvA N terminal domain; Region: RuvA_N; pfam01330 362948003579 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 362948003580 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 362948003581 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 362948003582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948003583 ATP binding site [chemical binding]; other site 362948003584 Mg2+ binding site [ion binding]; other site 362948003585 G-X-G motif; other site 362948003586 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 362948003587 ATP binding site [chemical binding]; other site 362948003588 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 362948003589 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 362948003590 MutS domain I; Region: MutS_I; pfam01624 362948003591 MutS domain II; Region: MutS_II; pfam05188 362948003592 MutS domain III; Region: MutS_III; pfam05192 362948003593 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 362948003594 Walker A/P-loop; other site 362948003595 ATP binding site [chemical binding]; other site 362948003596 Q-loop/lid; other site 362948003597 ABC transporter signature motif; other site 362948003598 Walker B; other site 362948003599 D-loop; other site 362948003600 H-loop/switch region; other site 362948003601 ribonuclease Y; Region: RNase_Y; TIGR03319 362948003602 KH domain; Region: KH_1; pfam00013 362948003603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948003604 Zn2+ binding site [ion binding]; other site 362948003605 Mg2+ binding site [ion binding]; other site 362948003606 recombinase A; Provisional; Region: recA; PRK09354 362948003607 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 362948003608 hexamer interface [polypeptide binding]; other site 362948003609 Walker A motif; other site 362948003610 ATP binding site [chemical binding]; other site 362948003611 Walker B motif; other site 362948003612 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 362948003613 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 362948003614 Helix-turn-helix domain; Region: HTH_25; pfam13413 362948003615 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 362948003616 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 362948003617 classical (c) SDRs; Region: SDR_c; cd05233 362948003618 NAD(P) binding site [chemical binding]; other site 362948003619 active site 362948003620 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 362948003621 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 362948003622 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362948003623 Similar to conserved hypothetical protein; nonfunctional due to interrupting stop codon 362948003624 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 362948003625 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 362948003626 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 362948003627 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 362948003628 Methyltransferase domain; Region: Methyltransf_31; pfam13847 362948003629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948003630 S-adenosylmethionine binding site [chemical binding]; other site 362948003631 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 362948003632 putative deacylase active site [active] 362948003633 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 362948003634 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 362948003635 active site 362948003636 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 362948003637 CutC family; Region: CutC; cl01218 362948003638 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 362948003639 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 362948003640 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 362948003641 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 362948003642 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 362948003643 active site 362948003644 substrate binding site [chemical binding]; other site 362948003645 metal binding site [ion binding]; metal-binding site 362948003646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 362948003647 YbbR-like protein; Region: YbbR; pfam07949 362948003648 YbbR-like protein; Region: YbbR; pfam07949 362948003649 Uncharacterized conserved protein [Function unknown]; Region: COG1624 362948003650 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 362948003651 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 362948003652 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 362948003653 FAD binding domain; Region: FAD_binding_4; pfam01565 362948003654 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 362948003655 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 362948003656 active site 362948003657 catalytic site [active] 362948003658 substrate binding site [chemical binding]; other site 362948003659 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 362948003660 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 362948003661 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 362948003662 ligand binding site [chemical binding]; other site 362948003663 active site 362948003664 UGI interface [polypeptide binding]; other site 362948003665 catalytic site [active] 362948003666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948003667 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 362948003668 active site 362948003669 motif I; other site 362948003670 motif II; other site 362948003671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948003672 motif II; other site 362948003673 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948003674 Tubby C 2; Region: Tub_2; cl02043 362948003675 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 362948003676 SmpB-tmRNA interface; other site 362948003677 ribonuclease R; Region: RNase_R; TIGR02063 362948003678 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 362948003679 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 362948003680 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 362948003681 RNA binding site [nucleotide binding]; other site 362948003682 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 362948003683 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 362948003684 Cl- selectivity filter; other site 362948003685 Cl- binding residues [ion binding]; other site 362948003686 pore gating glutamate residue; other site 362948003687 dimer interface [polypeptide binding]; other site 362948003688 H+/Cl- coupling transport residue; other site 362948003689 TrkA-C domain; Region: TrkA_C; pfam02080 362948003690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948003691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948003692 putative substrate translocation pore; other site 362948003693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 362948003694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362948003695 dimerization interface [polypeptide binding]; other site 362948003696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362948003697 dimer interface [polypeptide binding]; other site 362948003698 phosphorylation site [posttranslational modification] 362948003699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948003700 ATP binding site [chemical binding]; other site 362948003701 Mg2+ binding site [ion binding]; other site 362948003702 G-X-G motif; other site 362948003703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948003704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948003705 active site 362948003706 phosphorylation site [posttranslational modification] 362948003707 intermolecular recognition site; other site 362948003708 dimerization interface [polypeptide binding]; other site 362948003709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362948003710 DNA binding site [nucleotide binding] 362948003711 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 362948003712 active site 362948003713 DNA polymerase IV; Validated; Region: PRK02406 362948003714 DNA binding site [nucleotide binding] 362948003715 enolase; Provisional; Region: eno; PRK00077 362948003716 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 362948003717 dimer interface [polypeptide binding]; other site 362948003718 metal binding site [ion binding]; metal-binding site 362948003719 substrate binding pocket [chemical binding]; other site 362948003720 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 362948003721 substrate binding site [chemical binding]; other site 362948003722 dimer interface [polypeptide binding]; other site 362948003723 catalytic triad [active] 362948003724 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 362948003725 substrate binding site [chemical binding]; other site 362948003726 hinge regions; other site 362948003727 ADP binding site [chemical binding]; other site 362948003728 catalytic site [active] 362948003729 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 362948003730 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 362948003731 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 362948003732 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 362948003733 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 362948003734 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 362948003735 oligomer interface [polypeptide binding]; other site 362948003736 active site residues [active] 362948003737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 362948003738 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 362948003739 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 362948003740 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 362948003741 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 362948003742 phosphate binding site [ion binding]; other site 362948003743 putative substrate binding pocket [chemical binding]; other site 362948003744 dimer interface [polypeptide binding]; other site 362948003745 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 362948003746 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 362948003747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948003748 NAD(P) binding site [chemical binding]; other site 362948003749 active site 362948003750 S-ribosylhomocysteinase; Provisional; Region: PRK02260 362948003751 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 362948003752 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 362948003753 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 362948003754 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 362948003755 excinuclease ABC subunit B; Provisional; Region: PRK05298 362948003756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948003757 ATP binding site [chemical binding]; other site 362948003758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948003759 nucleotide binding region [chemical binding]; other site 362948003760 ATP-binding site [chemical binding]; other site 362948003761 Ultra-violet resistance protein B; Region: UvrB; pfam12344 362948003762 UvrB/uvrC motif; Region: UVR; pfam02151 362948003763 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 362948003764 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 362948003765 active site 362948003766 substrate binding site [chemical binding]; other site 362948003767 metal binding site [ion binding]; metal-binding site 362948003768 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 362948003769 HPr kinase/phosphorylase; Provisional; Region: PRK05428 362948003770 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 362948003771 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 362948003772 Hpr binding site; other site 362948003773 active site 362948003774 homohexamer subunit interaction site [polypeptide binding]; other site 362948003775 Membrane protein of unknown function; Region: DUF360; pfam04020 362948003776 PspC domain; Region: PspC; cl00864 362948003777 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 362948003778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362948003779 dimer interface [polypeptide binding]; other site 362948003780 phosphorylation site [posttranslational modification] 362948003781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948003782 ATP binding site [chemical binding]; other site 362948003783 Mg2+ binding site [ion binding]; other site 362948003784 G-X-G motif; other site 362948003785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948003786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948003787 active site 362948003788 phosphorylation site [posttranslational modification] 362948003789 intermolecular recognition site; other site 362948003790 dimerization interface [polypeptide binding]; other site 362948003791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362948003792 DNA binding site [nucleotide binding] 362948003793 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362948003794 protein binding site [polypeptide binding]; other site 362948003795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948003796 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948003797 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948003798 peptide chain release factor 2; Validated; Region: prfB; PRK00578 362948003799 This domain is found in peptide chain release factors; Region: PCRF; smart00937 362948003800 RF-1 domain; Region: RF-1; pfam00472 362948003801 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 362948003802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 362948003803 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 362948003804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948003805 nucleotide binding region [chemical binding]; other site 362948003806 ATP-binding site [chemical binding]; other site 362948003807 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 362948003808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948003809 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 362948003810 putative substrate translocation pore; other site 362948003811 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 362948003812 30S subunit binding site; other site 362948003813 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 362948003814 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948003815 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 362948003816 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948003817 Int/Topo IB signature motif; other site 362948003818 Domain of unknown function (DUF955); Region: DUF955; cl01076 362948003819 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948003820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948003821 non-specific DNA binding site [nucleotide binding]; other site 362948003822 salt bridge; other site 362948003823 sequence-specific DNA binding site [nucleotide binding]; other site 362948003824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948003825 non-specific DNA binding site [nucleotide binding]; other site 362948003826 salt bridge; other site 362948003827 sequence-specific DNA binding site [nucleotide binding]; other site 362948003828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948003829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948003830 non-specific DNA binding site [nucleotide binding]; other site 362948003831 salt bridge; other site 362948003832 sequence-specific DNA binding site [nucleotide binding]; other site 362948003833 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 362948003834 polymerase nucleotide-binding site; other site 362948003835 DNA-binding residues [nucleotide binding]; DNA binding site 362948003836 nucleotide binding site [chemical binding]; other site 362948003837 primase nucleotide-binding site [nucleotide binding]; other site 362948003838 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 362948003839 D5 N terminal like; Region: D5_N; smart00885 362948003840 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 362948003841 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 362948003842 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 362948003843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948003844 active site 362948003845 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 362948003846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948003847 ATP binding site [chemical binding]; other site 362948003848 putative Mg++ binding site [ion binding]; other site 362948003849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948003850 nucleotide binding region [chemical binding]; other site 362948003851 ATP-binding site [chemical binding]; other site 362948003852 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 362948003853 Mg++ binding site [ion binding]; other site 362948003854 putative catalytic motif [active] 362948003855 substrate binding site [chemical binding]; other site 362948003856 Amino acid permease; Region: AA_permease_2; pfam13520 362948003857 K+ potassium transporter; Region: K_trans; cl15781 362948003858 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 362948003859 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948003860 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 362948003861 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 362948003862 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 362948003863 ring oligomerisation interface [polypeptide binding]; other site 362948003864 ATP/Mg binding site [chemical binding]; other site 362948003865 stacking interactions; other site 362948003866 hinge regions; other site 362948003867 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 362948003868 oligomerisation interface [polypeptide binding]; other site 362948003869 mobile loop; other site 362948003870 roof hairpin; other site 362948003871 CAAX protease self-immunity; Region: Abi; pfam02517 362948003872 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 362948003873 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 362948003874 CoA binding domain; Region: CoA_binding; pfam02629 362948003875 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 362948003876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948003877 ABC transporter; Region: ABC_tran_2; pfam12848 362948003878 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362948003879 UGMP family protein; Validated; Region: PRK09604 362948003880 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 362948003881 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 362948003882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948003883 Coenzyme A binding pocket [chemical binding]; other site 362948003884 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 362948003885 Glycoprotease family; Region: Peptidase_M22; pfam00814 362948003886 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 362948003887 active site 362948003888 homotetramer interface [polypeptide binding]; other site 362948003889 homodimer interface [polypeptide binding]; other site 362948003890 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 362948003891 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 362948003892 active site 362948003893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 362948003894 active site 362948003895 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 362948003896 putative SAM binding site [chemical binding]; other site 362948003897 putative homodimer interface [polypeptide binding]; other site 362948003898 Protein of unknown function (DUF972); Region: DUF972; pfam06156 362948003899 DNA polymerase III subunit delta'; Validated; Region: PRK08058 362948003900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 362948003901 Walker A motif; other site 362948003902 ATP binding site [chemical binding]; other site 362948003903 DNA polymerase III subunit delta'; Validated; Region: PRK08485 362948003904 Walker B motif; other site 362948003905 arginine finger; other site 362948003906 thymidylate kinase; Validated; Region: tmk; PRK00698 362948003907 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 362948003908 TMP-binding site; other site 362948003909 ATP-binding site [chemical binding]; other site 362948003910 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 362948003911 recombination protein RecR; Reviewed; Region: recR; PRK00076 362948003912 RecR protein; Region: RecR; pfam02132 362948003913 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 362948003914 putative active site [active] 362948003915 putative metal-binding site [ion binding]; other site 362948003916 tetramer interface [polypeptide binding]; other site 362948003917 hypothetical protein; Validated; Region: PRK00153 362948003918 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 362948003919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948003920 Walker A motif; other site 362948003921 ATP binding site [chemical binding]; other site 362948003922 Walker B motif; other site 362948003923 arginine finger; other site 362948003924 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 362948003925 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 362948003926 nucleoside/Zn binding site; other site 362948003927 dimer interface [polypeptide binding]; other site 362948003928 catalytic motif [active] 362948003929 Similar to conserved hypothetical protein; nonfunctional due to interrupting stop codon 362948003930 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 362948003931 catalytic residues [active] 362948003932 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 362948003933 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 362948003934 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 362948003935 Class I ribonucleotide reductase; Region: RNR_I; cd01679 362948003936 active site 362948003937 dimer interface [polypeptide binding]; other site 362948003938 catalytic residues [active] 362948003939 effector binding site; other site 362948003940 R2 peptide binding site; other site 362948003941 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 362948003942 dimer interface [polypeptide binding]; other site 362948003943 putative radical transfer pathway; other site 362948003944 diiron center [ion binding]; other site 362948003945 tyrosyl radical; other site 362948003946 Predicted integral membrane protein [Function unknown]; Region: COG0392 362948003947 Uncharacterized conserved protein [Function unknown]; Region: COG2898 362948003948 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 362948003949 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 362948003950 core dimer interface [polypeptide binding]; other site 362948003951 peripheral dimer interface [polypeptide binding]; other site 362948003952 L10 interface [polypeptide binding]; other site 362948003953 L11 interface [polypeptide binding]; other site 362948003954 putative EF-Tu interaction site [polypeptide binding]; other site 362948003955 putative EF-G interaction site [polypeptide binding]; other site 362948003956 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 362948003957 23S rRNA interface [nucleotide binding]; other site 362948003958 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 362948003959 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 362948003960 mRNA/rRNA interface [nucleotide binding]; other site 362948003961 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 362948003962 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 362948003963 23S rRNA interface [nucleotide binding]; other site 362948003964 L7/L12 interface [polypeptide binding]; other site 362948003965 putative thiostrepton binding site; other site 362948003966 L25 interface [polypeptide binding]; other site 362948003967 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 362948003968 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 362948003969 putative homodimer interface [polypeptide binding]; other site 362948003970 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 362948003971 heterodimer interface [polypeptide binding]; other site 362948003972 homodimer interface [polypeptide binding]; other site 362948003973 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 362948003974 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 362948003975 YacP-like NYN domain; Region: NYN_YacP; pfam05991 362948003976 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 362948003977 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 362948003978 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 362948003979 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 362948003980 active site 362948003981 metal binding site [ion binding]; metal-binding site 362948003982 dimerization interface [polypeptide binding]; other site 362948003983 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 362948003984 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 362948003985 active site 362948003986 HIGH motif; other site 362948003987 KMSKS motif; other site 362948003988 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 362948003989 tRNA binding surface [nucleotide binding]; other site 362948003990 anticodon binding site; other site 362948003991 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 362948003992 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 362948003993 active site 362948003994 HIGH motif; other site 362948003995 KMSKS motif; other site 362948003996 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 362948003997 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 362948003998 putative active site [active] 362948003999 DNA repair protein RadA; Provisional; Region: PRK11823 362948004000 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 362948004001 Walker A motif/ATP binding site; other site 362948004002 ATP binding site [chemical binding]; other site 362948004003 Walker B motif; other site 362948004004 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 362948004005 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 362948004006 trimer interface [polypeptide binding]; other site 362948004007 active site 362948004008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948004009 Coenzyme A binding pocket [chemical binding]; other site 362948004010 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 362948004011 trimer interface [polypeptide binding]; other site 362948004012 active site 362948004013 G bulge; other site 362948004014 Enterocin A Immunity; Region: EntA_Immun; pfam08951 362948004015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948004016 catalytic core [active] 362948004017 Membrane transport protein; Region: Mem_trans; cl09117 362948004018 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 362948004019 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 362948004020 dimer interface [polypeptide binding]; other site 362948004021 active site 362948004022 CoA binding pocket [chemical binding]; other site 362948004023 hypothetical protein; Provisional; Region: PRK04351 362948004024 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 362948004025 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 362948004026 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 362948004027 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 362948004028 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 362948004029 RNA binding site [nucleotide binding]; other site 362948004030 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 362948004031 homodimer interface [polypeptide binding]; other site 362948004032 NAD binding pocket [chemical binding]; other site 362948004033 ATP binding pocket [chemical binding]; other site 362948004034 Mg binding site [ion binding]; other site 362948004035 active-site loop [active] 362948004036 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 362948004037 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 362948004038 active site 362948004039 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 362948004040 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 362948004041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362948004042 DNA-binding site [nucleotide binding]; DNA binding site 362948004043 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 362948004044 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 362948004045 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 362948004046 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 362948004047 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 362948004048 POT family; Region: PTR2; cl17359 362948004049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948004050 putative substrate translocation pore; other site 362948004051 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 362948004052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948004053 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 362948004054 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 362948004055 active site 362948004056 tetramer interface; other site 362948004057 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 362948004058 active site 362948004059 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 362948004060 GtrA-like protein; Region: GtrA; pfam04138 362948004061 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 362948004062 ornithine cyclodeaminase; Validated; Region: PRK08618 362948004063 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 362948004064 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 362948004065 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 362948004066 Predicted transcriptional regulators [Transcription]; Region: COG1378 362948004067 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 362948004068 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 362948004069 C-terminal domain interface [polypeptide binding]; other site 362948004070 sugar binding site [chemical binding]; other site 362948004071 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 362948004072 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 362948004073 active site 362948004074 homodimer interface [polypeptide binding]; other site 362948004075 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 362948004076 Amino acid permease; Region: AA_permease_2; pfam13520 362948004077 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948004078 beta-phosphoglucomutase; Region: bPGM; TIGR01990 362948004079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948004080 motif II; other site 362948004081 maltose phosphorylase; Provisional; Region: PRK13807 362948004082 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 362948004083 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 362948004084 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 362948004085 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 362948004086 active site 362948004087 catalytic residues [active] 362948004088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948004089 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 362948004090 putative substrate translocation pore; other site 362948004091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362948004092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362948004093 DNA binding site [nucleotide binding] 362948004094 domain linker motif; other site 362948004095 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 362948004096 putative dimerization interface [polypeptide binding]; other site 362948004097 putative ligand binding site [chemical binding]; other site 362948004098 K+ potassium transporter; Region: K_trans; pfam02705 362948004099 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 362948004100 DEAD-like helicases superfamily; Region: DEXDc; smart00487 362948004101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 362948004102 ATP binding site [chemical binding]; other site 362948004103 putative Mg++ binding site [ion binding]; other site 362948004104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948004105 nucleotide binding region [chemical binding]; other site 362948004106 ATP-binding site [chemical binding]; other site 362948004107 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362948004108 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362948004109 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 362948004110 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 362948004111 active site 362948004112 homodimer interface [polypeptide binding]; other site 362948004113 catalytic site [active] 362948004114 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 362948004115 homodimer interface [polypeptide binding]; other site 362948004116 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 362948004117 active site pocket [active] 362948004118 glycogen synthase; Provisional; Region: glgA; PRK00654 362948004119 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 362948004120 ADP-binding pocket [chemical binding]; other site 362948004121 homodimer interface [polypeptide binding]; other site 362948004122 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 362948004123 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 362948004124 ligand binding site; other site 362948004125 oligomer interface; other site 362948004126 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 362948004127 dimer interface [polypeptide binding]; other site 362948004128 N-terminal domain interface [polypeptide binding]; other site 362948004129 sulfate 1 binding site; other site 362948004130 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 362948004131 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 362948004132 ligand binding site; other site 362948004133 oligomer interface; other site 362948004134 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 362948004135 dimer interface [polypeptide binding]; other site 362948004136 N-terminal domain interface [polypeptide binding]; other site 362948004137 sulfate 1 binding site; other site 362948004138 glycogen branching enzyme; Provisional; Region: PRK12313 362948004139 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 362948004140 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 362948004141 active site 362948004142 catalytic site [active] 362948004143 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 362948004144 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 362948004145 homodimer interface [polypeptide binding]; other site 362948004146 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 362948004147 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 362948004148 active site 362948004149 homodimer interface [polypeptide binding]; other site 362948004150 catalytic site [active] 362948004151 glutamate dehydrogenase; Provisional; Region: PRK09414 362948004152 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 362948004153 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 362948004154 NAD(P) binding site [chemical binding]; other site 362948004155 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 362948004156 NAD(P) binding site [chemical binding]; other site 362948004157 catalytic residues [active] 362948004158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948004159 Coenzyme A binding pocket [chemical binding]; other site 362948004160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004161 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004162 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004163 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 362948004164 MgtE intracellular N domain; Region: MgtE_N; pfam03448 362948004165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 362948004166 Divalent cation transporter; Region: MgtE; cl00786 362948004167 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 362948004168 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362948004169 active site 362948004170 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 362948004171 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 362948004172 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 362948004173 synthetase active site [active] 362948004174 NTP binding site [chemical binding]; other site 362948004175 metal binding site [ion binding]; metal-binding site 362948004176 DNA topoisomerase III; Provisional; Region: PRK07726 362948004177 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 362948004178 active site 362948004179 putative interdomain interaction site [polypeptide binding]; other site 362948004180 putative metal-binding site [ion binding]; other site 362948004181 putative nucleotide binding site [chemical binding]; other site 362948004182 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 362948004183 domain I; other site 362948004184 DNA binding groove [nucleotide binding] 362948004185 phosphate binding site [ion binding]; other site 362948004186 domain II; other site 362948004187 domain III; other site 362948004188 nucleotide binding site [chemical binding]; other site 362948004189 catalytic site [active] 362948004190 domain IV; other site 362948004191 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362948004192 maltose O-acetyltransferase; Provisional; Region: PRK10092 362948004193 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 362948004194 active site 362948004195 substrate binding site [chemical binding]; other site 362948004196 trimer interface [polypeptide binding]; other site 362948004197 CoA binding site [chemical binding]; other site 362948004198 Sulfate transporter family; Region: Sulfate_transp; cl19250 362948004199 xanthine permease; Region: pbuX; TIGR03173 362948004200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948004201 active site 362948004202 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 362948004203 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 362948004204 Membrane transport protein; Region: Mem_trans; cl09117 362948004205 malate dehydrogenase; Provisional; Region: PRK13529 362948004206 Malic enzyme, N-terminal domain; Region: malic; pfam00390 362948004207 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 362948004208 NAD(P) binding pocket [chemical binding]; other site 362948004209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948004210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948004211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362948004212 dimerization interface [polypeptide binding]; other site 362948004213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948004214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 362948004215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948004216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948004217 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362948004218 Ligand Binding Site [chemical binding]; other site 362948004219 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948004220 Penicillinase repressor; Region: Penicillinase_R; cl17580 362948004221 Similar to hypothetical surface protein RlpA; nonfunctional due to interrupting stop codon 362948004222 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 362948004223 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362948004224 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 362948004225 maltose O-acetyltransferase; Provisional; Region: PRK10092 362948004226 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362948004227 putative trimer interface [polypeptide binding]; other site 362948004228 putative CoA binding site [chemical binding]; other site 362948004229 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 362948004230 anion transporter; Region: dass; TIGR00785 362948004231 transmembrane helices; other site 362948004232 L-aspartate oxidase; Provisional; Region: PRK06175 362948004233 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 362948004234 fumarate hydratase; Reviewed; Region: fumC; PRK00485 362948004235 Class II fumarases; Region: Fumarase_classII; cd01362 362948004236 active site 362948004237 tetramer interface [polypeptide binding]; other site 362948004238 Protein of unknown function (DUF454); Region: DUF454; cl01063 362948004239 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 362948004240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948004241 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 362948004242 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 362948004243 putative catalytic residues [active] 362948004244 thiol/disulfide switch; other site 362948004245 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 362948004246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362948004247 FeS/SAM binding site; other site 362948004248 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 362948004249 ATP cone domain; Region: ATP-cone; pfam03477 362948004250 Class III ribonucleotide reductase; Region: RNR_III; cd01675 362948004251 effector binding site; other site 362948004252 active site 362948004253 Zn binding site [ion binding]; other site 362948004254 glycine loop; other site 362948004255 hypothetical protein; Provisional; Region: PRK13690 362948004256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948004257 Coenzyme A binding pocket [chemical binding]; other site 362948004258 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 362948004259 MucBP domain; Region: MucBP; pfam06458 362948004260 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 362948004261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362948004262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948004263 Coenzyme A binding pocket [chemical binding]; other site 362948004264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948004265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948004266 non-specific DNA binding site [nucleotide binding]; other site 362948004267 salt bridge; other site 362948004268 sequence-specific DNA binding site [nucleotide binding]; other site 362948004269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004270 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004271 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004272 TRAM domain; Region: TRAM; cl01282 362948004273 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 362948004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948004275 S-adenosylmethionine binding site [chemical binding]; other site 362948004276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004277 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004278 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004279 putative lipid kinase; Reviewed; Region: PRK13055 362948004280 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 362948004281 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 362948004282 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 362948004283 GatB domain; Region: GatB_Yqey; pfam02637 362948004284 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 362948004285 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 362948004286 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 362948004287 putative dimer interface [polypeptide binding]; other site 362948004288 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 362948004289 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 362948004290 putative dimer interface [polypeptide binding]; other site 362948004291 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 362948004292 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 362948004293 nucleotide binding pocket [chemical binding]; other site 362948004294 K-X-D-G motif; other site 362948004295 catalytic site [active] 362948004296 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 362948004297 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 362948004298 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 362948004299 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 362948004300 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 362948004301 Dimer interface [polypeptide binding]; other site 362948004302 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 362948004303 Part of AAA domain; Region: AAA_19; pfam13245 362948004304 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948004305 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 362948004306 NAD binding site [chemical binding]; other site 362948004307 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362948004308 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 362948004309 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 362948004310 dimer interface [polypeptide binding]; other site 362948004311 putative anticodon binding site; other site 362948004312 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 362948004313 motif 1; other site 362948004314 active site 362948004315 motif 2; other site 362948004316 motif 3; other site 362948004317 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 362948004318 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 362948004319 FMN binding site [chemical binding]; other site 362948004320 active site 362948004321 catalytic residues [active] 362948004322 substrate binding site [chemical binding]; other site 362948004323 Similar to 33 kDa chaperonin; nonfunctional due to interrupting stop codon 362948004324 FtsH Extracellular; Region: FtsH_ext; pfam06480 362948004325 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 362948004326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948004327 Walker A motif; other site 362948004328 ATP binding site [chemical binding]; other site 362948004329 Walker B motif; other site 362948004330 arginine finger; other site 362948004331 Peptidase family M41; Region: Peptidase_M41; pfam01434 362948004332 Synaptonemal complex central element protein 1; Region: SYCE1; pfam15233 362948004333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948004334 active site 362948004335 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 362948004336 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 362948004337 Ligand Binding Site [chemical binding]; other site 362948004338 TilS substrate C-terminal domain; Region: TilS_C; smart00977 362948004339 hypothetical protein; Provisional; Region: PRK08582 362948004340 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362948004341 RNA binding site [nucleotide binding]; other site 362948004342 Septum formation initiator; Region: DivIC; pfam04977 362948004343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948004344 RNA binding surface [nucleotide binding]; other site 362948004345 stage V sporulation protein B; Region: spore_V_B; TIGR02900 362948004346 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 362948004347 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 362948004348 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 362948004349 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 362948004350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948004351 ATP binding site [chemical binding]; other site 362948004352 putative Mg++ binding site [ion binding]; other site 362948004353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948004354 nucleotide binding region [chemical binding]; other site 362948004355 ATP-binding site [chemical binding]; other site 362948004356 TRCF domain; Region: TRCF; pfam03461 362948004357 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 362948004358 putative active site [active] 362948004359 catalytic residue [active] 362948004360 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 362948004361 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 362948004362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362948004363 NAD binding site [chemical binding]; other site 362948004364 dimer interface [polypeptide binding]; other site 362948004365 substrate binding site [chemical binding]; other site 362948004366 Restriction endonuclease; Region: Mrr_cat; pfam04471 362948004367 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 362948004368 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 362948004369 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 362948004370 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 362948004371 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 362948004372 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 362948004373 active site 362948004374 nucleotide binding site [chemical binding]; other site 362948004375 HIGH motif; other site 362948004376 KMSKS motif; other site 362948004377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362948004378 RNA binding surface [nucleotide binding]; other site 362948004379 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 362948004380 metal binding site 2 [ion binding]; metal-binding site 362948004381 putative DNA binding helix; other site 362948004382 metal binding site 1 [ion binding]; metal-binding site 362948004383 dimer interface [polypeptide binding]; other site 362948004384 structural Zn2+ binding site [ion binding]; other site 362948004385 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 362948004386 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 362948004387 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 362948004388 Walker A/P-loop; other site 362948004389 ATP binding site [chemical binding]; other site 362948004390 Q-loop/lid; other site 362948004391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 362948004392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948004393 ABC transporter signature motif; other site 362948004394 Walker B; other site 362948004395 D-loop; other site 362948004396 H-loop/switch region; other site 362948004397 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 362948004398 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 362948004399 active site 362948004400 metal binding site [ion binding]; metal-binding site 362948004401 DNA binding site [nucleotide binding] 362948004402 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 362948004403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362948004404 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 362948004405 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 362948004406 PYR/PP interface [polypeptide binding]; other site 362948004407 dimer interface [polypeptide binding]; other site 362948004408 tetramer interface [polypeptide binding]; other site 362948004409 TPP binding site [chemical binding]; other site 362948004410 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362948004411 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 362948004412 TPP-binding site [chemical binding]; other site 362948004413 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 362948004414 Similar to transcriptional regulator, TetR family; nonfunctional due to frameshift 362948004415 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 362948004416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362948004417 FtsX-like permease family; Region: FtsX; pfam02687 362948004418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948004419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362948004420 Walker A/P-loop; other site 362948004421 ATP binding site [chemical binding]; other site 362948004422 Q-loop/lid; other site 362948004423 ABC transporter signature motif; other site 362948004424 Walker B; other site 362948004425 D-loop; other site 362948004426 H-loop/switch region; other site 362948004427 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 362948004428 dimer interface [polypeptide binding]; other site 362948004429 FMN binding site [chemical binding]; other site 362948004430 NADPH bind site [chemical binding]; other site 362948004431 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 362948004432 Part of AAA domain; Region: AAA_19; pfam13245 362948004433 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948004434 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 362948004435 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 362948004436 TrkA-N domain; Region: TrkA_N; pfam02254 362948004437 TrkA-C domain; Region: TrkA_C; pfam02080 362948004438 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 362948004439 Similar to conserved hypothetical protein; nonfunctional due to frameshift and interrupting stop codon 362948004440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004441 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004442 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004443 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 362948004444 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 362948004445 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362948004446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948004447 Walker A/P-loop; other site 362948004448 ATP binding site [chemical binding]; other site 362948004449 Q-loop/lid; other site 362948004450 ABC transporter signature motif; other site 362948004451 Walker B; other site 362948004452 D-loop; other site 362948004453 H-loop/switch region; other site 362948004454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362948004455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948004456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004457 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004458 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004459 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 362948004460 Similar to transposase ISLasa10, IS256 family; nonfunctional due to truncation 362948004461 Fic/DOC family; Region: Fic; cl00960 362948004462 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 362948004463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948004464 Walker A/P-loop; other site 362948004465 ATP binding site [chemical binding]; other site 362948004466 Restriction endonuclease; Region: Mrr_cat; cl19295 362948004467 Similar to transposase ISLasa11, IS30 family; nonfunctional due to frameshift 362948004468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948004469 short chain dehydrogenase; Region: adh_short; pfam00106 362948004470 NAD(P) binding site [chemical binding]; other site 362948004471 active site 362948004472 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 362948004473 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 362948004474 putative active site [active] 362948004475 putative metal binding site [ion binding]; other site 362948004476 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 362948004477 Similar to hydrolase, TatD family; nonfunctional due to frameshift 362948004478 Similar to alcohol dehydrogenase; nonfunctional due to interrupting stop codon 362948004479 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 362948004480 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 362948004481 23S rRNA interface [nucleotide binding]; other site 362948004482 L3 interface [polypeptide binding]; other site 362948004483 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 362948004484 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 362948004485 dimerization interface 3.5A [polypeptide binding]; other site 362948004486 active site 362948004487 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 362948004488 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 362948004489 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362948004490 Walker A/P-loop; other site 362948004491 ATP binding site [chemical binding]; other site 362948004492 Q-loop/lid; other site 362948004493 ABC transporter signature motif; other site 362948004494 Walker B; other site 362948004495 D-loop; other site 362948004496 H-loop/switch region; other site 362948004497 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 362948004498 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362948004499 Walker A/P-loop; other site 362948004500 ATP binding site [chemical binding]; other site 362948004501 Q-loop/lid; other site 362948004502 ABC transporter signature motif; other site 362948004503 Walker B; other site 362948004504 D-loop; other site 362948004505 H-loop/switch region; other site 362948004506 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 362948004507 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 362948004508 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 362948004509 alphaNTD homodimer interface [polypeptide binding]; other site 362948004510 alphaNTD - beta interaction site [polypeptide binding]; other site 362948004511 alphaNTD - beta' interaction site [polypeptide binding]; other site 362948004512 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 362948004513 30S ribosomal protein S11; Validated; Region: PRK05309 362948004514 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 362948004515 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 362948004516 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 362948004517 rRNA binding site [nucleotide binding]; other site 362948004518 predicted 30S ribosome binding site; other site 362948004519 adenylate kinase; Reviewed; Region: adk; PRK00279 362948004520 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 362948004521 AMP-binding site [chemical binding]; other site 362948004522 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 362948004523 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 362948004524 SecY translocase; Region: SecY; pfam00344 362948004525 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 362948004526 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 362948004527 23S rRNA binding site [nucleotide binding]; other site 362948004528 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 362948004529 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 362948004530 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 362948004531 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 362948004532 5S rRNA interface [nucleotide binding]; other site 362948004533 L27 interface [polypeptide binding]; other site 362948004534 23S rRNA interface [nucleotide binding]; other site 362948004535 L5 interface [polypeptide binding]; other site 362948004536 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 362948004537 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 362948004538 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 362948004539 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 362948004540 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 362948004541 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 362948004542 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 362948004543 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 362948004544 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 362948004545 RNA binding site [nucleotide binding]; other site 362948004546 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 362948004547 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 362948004548 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 362948004549 23S rRNA interface [nucleotide binding]; other site 362948004550 putative translocon interaction site; other site 362948004551 signal recognition particle (SRP54) interaction site; other site 362948004552 L23 interface [polypeptide binding]; other site 362948004553 trigger factor interaction site; other site 362948004554 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 362948004555 23S rRNA interface [nucleotide binding]; other site 362948004556 5S rRNA interface [nucleotide binding]; other site 362948004557 putative antibiotic binding site [chemical binding]; other site 362948004558 L25 interface [polypeptide binding]; other site 362948004559 L27 interface [polypeptide binding]; other site 362948004560 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 362948004561 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 362948004562 G-X-X-G motif; other site 362948004563 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 362948004564 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 362948004565 putative translocon binding site; other site 362948004566 protein-rRNA interface [nucleotide binding]; other site 362948004567 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 362948004568 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 362948004569 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 362948004570 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 362948004571 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 362948004572 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 362948004573 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 362948004574 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 362948004575 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 362948004576 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 362948004577 HflX GTPase family; Region: HflX; cd01878 362948004578 G1 box; other site 362948004579 GTP/Mg2+ binding site [chemical binding]; other site 362948004580 Switch I region; other site 362948004581 G2 box; other site 362948004582 G3 box; other site 362948004583 Switch II region; other site 362948004584 G4 box; other site 362948004585 G5 box; other site 362948004586 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 362948004587 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362948004588 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362948004589 putative active site [active] 362948004590 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 362948004591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362948004592 active site 362948004593 dimer interface [polypeptide binding]; other site 362948004594 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362948004595 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362948004596 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362948004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948004598 Coenzyme A binding pocket [chemical binding]; other site 362948004599 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948004600 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 362948004601 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948004602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948004603 dimer interface [polypeptide binding]; other site 362948004604 conserved gate region; other site 362948004605 putative PBP binding loops; other site 362948004606 ABC-ATPase subunit interface; other site 362948004607 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948004609 dimer interface [polypeptide binding]; other site 362948004610 conserved gate region; other site 362948004611 putative PBP binding loops; other site 362948004612 ABC-ATPase subunit interface; other site 362948004613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948004614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948004615 substrate binding pocket [chemical binding]; other site 362948004616 membrane-bound complex binding site; other site 362948004617 hinge residues; other site 362948004618 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362948004619 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362948004620 Walker A/P-loop; other site 362948004621 ATP binding site [chemical binding]; other site 362948004622 Q-loop/lid; other site 362948004623 ABC transporter signature motif; other site 362948004624 Walker B; other site 362948004625 D-loop; other site 362948004626 H-loop/switch region; other site 362948004627 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 362948004628 metal binding site 2 [ion binding]; metal-binding site 362948004629 putative DNA binding helix; other site 362948004630 metal binding site 1 [ion binding]; metal-binding site 362948004631 dimer interface [polypeptide binding]; other site 362948004632 structural Zn2+ binding site [ion binding]; other site 362948004633 amino acid transporter; Region: 2A0306; TIGR00909 362948004634 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948004635 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 362948004636 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 362948004637 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 362948004638 active site 362948004639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 362948004640 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 362948004641 PLD-like domain; Region: PLDc_2; pfam13091 362948004642 putative homodimer interface [polypeptide binding]; other site 362948004643 putative active site [active] 362948004644 catalytic site [active] 362948004645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 362948004646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948004647 ATP binding site [chemical binding]; other site 362948004648 putative Mg++ binding site [ion binding]; other site 362948004649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362948004650 nucleotide binding region [chemical binding]; other site 362948004651 ATP-binding site [chemical binding]; other site 362948004652 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 362948004653 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 362948004654 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 362948004655 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 362948004656 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 362948004657 Domain of unknown function DUF21; Region: DUF21; pfam01595 362948004658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362948004659 Transporter associated domain; Region: CorC_HlyC; smart01091 362948004660 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 362948004661 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362948004662 active site 362948004663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362948004664 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 362948004665 FtsX-like permease family; Region: FtsX; pfam02687 362948004666 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948004667 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362948004668 Walker A/P-loop; other site 362948004669 ATP binding site [chemical binding]; other site 362948004670 Q-loop/lid; other site 362948004671 ABC transporter signature motif; other site 362948004672 Walker B; other site 362948004673 D-loop; other site 362948004674 H-loop/switch region; other site 362948004675 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 362948004676 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 362948004677 HlyD family secretion protein; Region: HlyD_3; pfam13437 362948004678 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 362948004679 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362948004680 nucleotide binding site [chemical binding]; other site 362948004681 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 362948004682 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 362948004683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 362948004684 dimer interface [polypeptide binding]; other site 362948004685 metal binding site [ion binding]; metal-binding site 362948004686 Putative lysophospholipase; Region: Hydrolase_4; cl19140 362948004687 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 362948004688 active site 362948004689 trimer interface [polypeptide binding]; other site 362948004690 allosteric site; other site 362948004691 active site lid [active] 362948004692 hexamer (dimer of trimers) interface [polypeptide binding]; other site 362948004693 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 362948004694 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 362948004695 active site 362948004696 dimer interface [polypeptide binding]; other site 362948004697 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 362948004698 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 362948004699 metal binding site [ion binding]; metal-binding site 362948004700 dimer interface [polypeptide binding]; other site 362948004701 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 362948004702 classical (c) SDRs; Region: SDR_c; cd05233 362948004703 NAD(P) binding site [chemical binding]; other site 362948004704 active site 362948004705 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 362948004706 QueT transporter; Region: QueT; pfam06177 362948004707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004708 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004709 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004710 Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360 362948004711 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 362948004712 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 362948004713 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362948004714 catalytic residues [active] 362948004715 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 362948004716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948004717 active site 362948004718 motif I; other site 362948004719 motif II; other site 362948004720 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948004721 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 362948004722 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 362948004723 Uncharacterized conserved protein [Function unknown]; Region: COG2966 362948004724 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 362948004725 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362948004726 DNA-binding site [nucleotide binding]; DNA binding site 362948004727 RNA-binding motif; other site 362948004728 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 362948004729 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 362948004730 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 362948004731 FeoA domain; Region: FeoA; pfam04023 362948004732 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 362948004733 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362948004734 active site 362948004735 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 362948004736 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362948004737 active site 362948004738 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 362948004739 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 362948004740 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 362948004741 AzlC protein; Region: AzlC; pfam03591 362948004742 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 362948004743 active site 362948004744 putative catalytic site [active] 362948004745 DNA binding site [nucleotide binding] 362948004746 putative phosphate binding site [ion binding]; other site 362948004747 metal binding site A [ion binding]; metal-binding site 362948004748 AP binding site [nucleotide binding]; other site 362948004749 metal binding site B [ion binding]; metal-binding site 362948004750 Predicted membrane protein [Function unknown]; Region: COG1511 362948004751 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 362948004752 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 362948004753 Talin, middle domain; Region: Talin_middle; pfam09141 362948004754 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 362948004755 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 362948004756 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 362948004757 Double zinc ribbon; Region: DZR; pfam12773 362948004758 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 362948004759 Double zinc ribbon; Region: DZR; pfam12773 362948004760 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 362948004761 Double zinc ribbon; Region: DZR; pfam12773 362948004762 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948004763 catalytic core [active] 362948004764 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 362948004765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948004766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948004767 homodimer interface [polypeptide binding]; other site 362948004768 catalytic residue [active] 362948004769 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 362948004770 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 362948004771 EamA-like transporter family; Region: EamA; pfam00892 362948004772 EamA-like transporter family; Region: EamA; pfam00892 362948004773 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 362948004774 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948004775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948004776 motif II; other site 362948004777 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 362948004778 active site 362948004779 catalytic residues [active] 362948004780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362948004781 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 362948004782 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948004783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948004784 dimerization interface [polypeptide binding]; other site 362948004785 putative Zn2+ binding site [ion binding]; other site 362948004786 putative DNA binding site [nucleotide binding]; other site 362948004787 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 362948004788 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 362948004789 NAD binding site [chemical binding]; other site 362948004790 homodimer interface [polypeptide binding]; other site 362948004791 active site 362948004792 substrate binding site [chemical binding]; other site 362948004793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362948004794 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 362948004795 DNA-binding site [nucleotide binding]; DNA binding site 362948004796 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 362948004797 putative phosphoketolase; Provisional; Region: PRK05261 362948004798 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 362948004799 TPP-binding site; other site 362948004800 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 362948004801 XFP C-terminal domain; Region: XFP_C; pfam09363 362948004802 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 362948004803 catalytic triad [active] 362948004804 conserved cis-peptide bond; other site 362948004805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948004806 catalytic core [active] 362948004807 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 362948004808 HPr interaction site; other site 362948004809 glycerol kinase (GK) interaction site [polypeptide binding]; other site 362948004810 active site 362948004811 phosphorylation site [posttranslational modification] 362948004812 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 362948004813 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362948004814 active site turn [active] 362948004815 phosphorylation site [posttranslational modification] 362948004816 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362948004817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362948004818 DNA-binding site [nucleotide binding]; DNA binding site 362948004819 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 362948004820 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 362948004821 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 362948004822 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 362948004823 Ca binding site [ion binding]; other site 362948004824 active site 362948004825 catalytic site [active] 362948004826 drug efflux system protein MdtG; Provisional; Region: PRK09874 362948004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948004828 putative substrate translocation pore; other site 362948004829 Similar to conserved hypothetical protein; nonfunctional due to frameshift 362948004830 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 362948004831 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 362948004832 amidase catalytic site [active] 362948004833 Zn binding residues [ion binding]; other site 362948004834 substrate binding site [chemical binding]; other site 362948004835 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 362948004836 BDLF3; Provisional; Region: PHA03255 362948004837 homoserine kinase; Provisional; Region: PRK01212 362948004838 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362948004839 homoserine dehydrogenase; Provisional; Region: PRK06349 362948004840 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 362948004841 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 362948004842 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 362948004843 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 362948004844 threonine synthase; Validated; Region: PRK09225 362948004845 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 362948004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948004847 catalytic residue [active] 362948004848 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 362948004849 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 362948004850 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 362948004851 Predicted integral membrane protein [Function unknown]; Region: COG5617 362948004852 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 362948004853 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948004854 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 362948004855 Similar to conserved hypothetical protein; nonfunctional due to frameshift 362948004856 Similar to hpothetical membrane spanning protein; nonfunctional due to frameshift 362948004857 Acyltransferase family; Region: Acyl_transf_3; pfam01757 362948004858 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 362948004859 active site 362948004860 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 362948004861 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362948004862 PAS domain; Region: PAS_10; pfam13596 362948004863 Predicted flavoprotein [General function prediction only]; Region: COG0431 362948004864 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 362948004865 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 362948004866 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 362948004867 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 362948004868 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 362948004869 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 362948004870 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 362948004871 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 362948004872 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 362948004873 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 362948004874 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 362948004875 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 362948004876 putative active site [active] 362948004877 conserved hypothetical integral membrane protein; Region: TIGR03766 362948004878 GMP synthase; Reviewed; Region: guaA; PRK00074 362948004879 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 362948004880 AMP/PPi binding site [chemical binding]; other site 362948004881 candidate oxyanion hole; other site 362948004882 catalytic triad [active] 362948004883 potential glutamine specificity residues [chemical binding]; other site 362948004884 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 362948004885 ATP Binding subdomain [chemical binding]; other site 362948004886 Ligand Binding sites [chemical binding]; other site 362948004887 Dimerization subdomain; other site 362948004888 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 362948004889 ATP-binding site [chemical binding]; other site 362948004890 CoA-binding site [chemical binding]; other site 362948004891 Mg2+-binding site [ion binding]; other site 362948004892 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 362948004893 catalytic triad [active] 362948004894 oxyanion hole [active] 362948004895 active site 362948004896 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 362948004897 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362948004898 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362948004899 Walker A/P-loop; other site 362948004900 ATP binding site [chemical binding]; other site 362948004901 Q-loop/lid; other site 362948004902 ABC transporter signature motif; other site 362948004903 Walker B; other site 362948004904 D-loop; other site 362948004905 H-loop/switch region; other site 362948004906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948004907 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948004908 substrate binding pocket [chemical binding]; other site 362948004909 membrane-bound complex binding site; other site 362948004910 hinge residues; other site 362948004911 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948004912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948004913 dimer interface [polypeptide binding]; other site 362948004914 conserved gate region; other site 362948004915 putative PBP binding loops; other site 362948004916 ABC-ATPase subunit interface; other site 362948004917 inner membrane transporter YjeM; Provisional; Region: PRK15238 362948004918 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948004919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 362948004920 metal binding site [ion binding]; metal-binding site 362948004921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948004922 putative substrate translocation pore; other site 362948004923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948004924 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 362948004925 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 362948004926 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 362948004927 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 362948004928 Peptidase family M23; Region: Peptidase_M23; pfam01551 362948004929 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 362948004930 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 362948004931 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 362948004932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 362948004933 UDP-galactopyranose mutase; Region: GLF; pfam03275 362948004934 Core-2/I-Branching enzyme; Region: Branch; pfam02485 362948004935 Bacterial sugar transferase; Region: Bac_transf; pfam02397 362948004936 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 362948004937 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 362948004938 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 362948004939 AAA domain; Region: AAA_31; pfam13614 362948004940 Chain length determinant protein; Region: Wzz; pfam02706 362948004941 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 362948004942 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 362948004943 Similar to glycerol-3-phosphate cytidylyltransferase; nonfunctional due to frameshift 362948004944 Similar to lipooligosaccharide cholinephosphotransferase; nonfunctional due to frameshift 362948004945 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 362948004946 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 362948004947 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 362948004948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948004949 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 362948004950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948004951 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 362948004952 putative ADP-binding pocket [chemical binding]; other site 362948004953 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362948004954 active site 362948004955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362948004956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362948004957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 362948004958 catalytic residue [active] 362948004959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948004960 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948004961 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948004962 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 362948004963 Part of AAA domain; Region: AAA_19; pfam13245 362948004964 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 362948004965 AAA ATPase domain; Region: AAA_15; pfam13175 362948004966 AAA domain; Region: AAA_21; pfam13304 362948004967 AAA domain; Region: AAA_21; pfam13304 362948004968 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 362948004969 putative active site [active] 362948004970 putative metal-binding site [ion binding]; other site 362948004971 Predicted membrane protein [Function unknown]; Region: COG4640 362948004972 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 362948004973 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 362948004974 Double zinc ribbon; Region: DZR; pfam12773 362948004975 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 362948004976 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 362948004977 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 362948004978 NADP binding site [chemical binding]; other site 362948004979 active site 362948004980 putative substrate binding site [chemical binding]; other site 362948004981 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 362948004982 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 362948004983 NAD binding site [chemical binding]; other site 362948004984 substrate binding site [chemical binding]; other site 362948004985 homodimer interface [polypeptide binding]; other site 362948004986 active site 362948004987 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 362948004988 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 362948004989 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 362948004990 substrate binding site; other site 362948004991 tetramer interface; other site 362948004992 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362948004993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 362948004994 active site 362948004995 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 362948004996 CAAX protease self-immunity; Region: Abi; pfam02517 362948004997 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 362948004998 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 362948004999 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 362948005000 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 362948005001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948005002 motif II; other site 362948005003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005004 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948005005 putative substrate translocation pore; other site 362948005006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362948005007 Zn2+ binding site [ion binding]; other site 362948005008 Mg2+ binding site [ion binding]; other site 362948005009 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 362948005010 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 362948005011 DNA binding residues [nucleotide binding] 362948005012 putative dimer interface [polypeptide binding]; other site 362948005013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362948005014 Site-specific recombinase; Region: SpecificRecomb; cl15411 362948005015 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 362948005016 dimer interface [polypeptide binding]; other site 362948005017 substrate binding site [chemical binding]; other site 362948005018 ATP binding site [chemical binding]; other site 362948005019 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 362948005020 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362948005021 ABC-ATPase subunit interface; other site 362948005022 dimer interface [polypeptide binding]; other site 362948005023 putative PBP binding regions; other site 362948005024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948005025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948005026 Walker A/P-loop; other site 362948005027 ATP binding site [chemical binding]; other site 362948005028 Q-loop/lid; other site 362948005029 ABC transporter signature motif; other site 362948005030 Walker B; other site 362948005031 D-loop; other site 362948005032 H-loop/switch region; other site 362948005033 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 362948005034 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 362948005035 metal binding site [ion binding]; metal-binding site 362948005036 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 362948005037 Similar to transposase ISLasa3b, IS200 family; nonfunctional due to frameshift 362948005038 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 362948005039 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 362948005040 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 362948005041 GTP-binding protein YchF; Reviewed; Region: PRK09601 362948005042 YchF GTPase; Region: YchF; cd01900 362948005043 G1 box; other site 362948005044 GTP/Mg2+ binding site [chemical binding]; other site 362948005045 Switch I region; other site 362948005046 G2 box; other site 362948005047 Switch II region; other site 362948005048 G3 box; other site 362948005049 G4 box; other site 362948005050 G5 box; other site 362948005051 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 362948005052 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 362948005053 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 362948005054 ParB-like nuclease domain; Region: ParBc; pfam02195 362948005055 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 362948005056 KorB domain; Region: KorB; pfam08535 362948005057 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 362948005058 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 362948005059 P-loop; other site 362948005060 Magnesium ion binding site [ion binding]; other site 362948005061 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 362948005062 ParB-like nuclease domain; Region: ParBc; pfam02195 362948005063 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 362948005064 Methyltransferase domain; Region: Methyltransf_31; pfam13847 362948005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362948005066 S-adenosylmethionine binding site [chemical binding]; other site 362948005067 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 362948005068 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362948005069 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 362948005070 NAD binding site [chemical binding]; other site 362948005071 dimer interface [polypeptide binding]; other site 362948005072 substrate binding site [chemical binding]; other site 362948005073 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 362948005074 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 362948005075 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 362948005076 putative active site [active] 362948005077 catalytic site [active] 362948005078 putative metal binding site [ion binding]; other site 362948005079 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 362948005080 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 362948005081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948005082 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 362948005083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948005084 motif II; other site 362948005085 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 362948005086 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 362948005087 DJ-1 family protein; Region: not_thiJ; TIGR01383 362948005088 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 362948005089 conserved cys residue [active] 362948005090 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 362948005091 active site 362948005092 catalytic site [active] 362948005093 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 362948005094 Part of AAA domain; Region: AAA_19; pfam13245 362948005095 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 362948005096 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 362948005097 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 362948005098 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 362948005099 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 362948005100 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 362948005101 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 362948005102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362948005103 active site 362948005104 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 362948005105 putative catalytic cysteine [active] 362948005106 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 362948005107 nucleotide binding site [chemical binding]; other site 362948005108 homotetrameric interface [polypeptide binding]; other site 362948005109 putative phosphate binding site [ion binding]; other site 362948005110 putative allosteric binding site; other site 362948005111 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 362948005112 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 362948005113 hypothetical protein; Provisional; Region: PRK00967 362948005114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362948005115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948005116 Walker A/P-loop; other site 362948005117 ATP binding site [chemical binding]; other site 362948005118 Q-loop/lid; other site 362948005119 ABC transporter signature motif; other site 362948005120 Walker B; other site 362948005121 D-loop; other site 362948005122 H-loop/switch region; other site 362948005123 Predicted transcriptional regulators [Transcription]; Region: COG1725 362948005124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362948005125 DNA-binding site [nucleotide binding]; DNA binding site 362948005126 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 362948005127 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362948005128 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362948005129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362948005130 active site 362948005131 phosphorylation site [posttranslational modification] 362948005132 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 362948005133 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 362948005134 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 362948005135 active site 362948005136 P-loop; other site 362948005137 phosphorylation site [posttranslational modification] 362948005138 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 362948005139 active site 362948005140 P-loop; other site 362948005141 phosphorylation site [posttranslational modification] 362948005142 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 362948005143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005144 non-specific DNA binding site [nucleotide binding]; other site 362948005145 salt bridge; other site 362948005146 sequence-specific DNA binding site [nucleotide binding]; other site 362948005147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362948005148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 362948005149 substrate binding pocket [chemical binding]; other site 362948005150 membrane-bound complex binding site; other site 362948005151 hinge residues; other site 362948005152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948005153 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948005154 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948005155 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362948005156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948005157 Walker A/P-loop; other site 362948005158 ATP binding site [chemical binding]; other site 362948005159 Q-loop/lid; other site 362948005160 ABC transporter signature motif; other site 362948005161 Walker B; other site 362948005162 D-loop; other site 362948005163 H-loop/switch region; other site 362948005164 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 362948005165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948005166 dimer interface [polypeptide binding]; other site 362948005167 conserved gate region; other site 362948005168 putative PBP binding loops; other site 362948005169 ABC-ATPase subunit interface; other site 362948005170 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 362948005171 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 362948005172 glutaminase active site [active] 362948005173 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 362948005174 dimer interface [polypeptide binding]; other site 362948005175 active site 362948005176 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 362948005177 dimer interface [polypeptide binding]; other site 362948005178 active site 362948005179 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 362948005180 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 362948005181 DNA-binding interface [nucleotide binding]; DNA binding site 362948005182 Mga helix-turn-helix domain; Region: Mga; pfam05043 362948005183 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 362948005184 active site 362948005185 P-loop; other site 362948005186 phosphorylation site [posttranslational modification] 362948005187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 362948005188 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 362948005189 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 362948005190 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 362948005191 amphipathic channel; other site 362948005192 Asn-Pro-Ala signature motifs; other site 362948005193 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 362948005194 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 362948005195 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 362948005196 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 362948005197 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 362948005198 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 362948005199 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 362948005200 Similar to nitroreductase family protein; nonfunctional due to frameshift 362948005201 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 362948005202 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948005203 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948005204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948005205 dimerization interface [polypeptide binding]; other site 362948005206 putative DNA binding site [nucleotide binding]; other site 362948005207 putative Zn2+ binding site [ion binding]; other site 362948005208 myosin-cross-reactive antigen; Provisional; Region: PRK13977 362948005209 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100 362948005210 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 362948005211 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 362948005212 Substrate-binding site [chemical binding]; other site 362948005213 Substrate specificity [chemical binding]; other site 362948005214 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 362948005215 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 362948005216 Predicted membrane protein [Function unknown]; Region: COG4392 362948005217 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362948005218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948005219 putative DNA binding site [nucleotide binding]; other site 362948005220 putative Zn2+ binding site [ion binding]; other site 362948005221 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 362948005222 Jag N-terminus; Region: Jag_N; pfam14804 362948005223 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 362948005224 G-X-X-G motif; other site 362948005225 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 362948005226 RxxxH motif; other site 362948005227 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 362948005228 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948005229 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 362948005230 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948005231 Int/Topo IB signature motif; other site 362948005232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948005233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005234 non-specific DNA binding site [nucleotide binding]; other site 362948005235 salt bridge; other site 362948005236 sequence-specific DNA binding site [nucleotide binding]; other site 362948005237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005238 non-specific DNA binding site [nucleotide binding]; other site 362948005239 salt bridge; other site 362948005240 sequence-specific DNA binding site [nucleotide binding]; other site 362948005241 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 362948005242 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 362948005243 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 362948005244 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 362948005245 polymerase nucleotide-binding site; other site 362948005246 DNA-binding residues [nucleotide binding]; DNA binding site 362948005247 nucleotide binding site [chemical binding]; other site 362948005248 primase nucleotide-binding site [nucleotide binding]; other site 362948005249 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 362948005250 D5 N terminal like; Region: D5_N; smart00885 362948005251 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 362948005252 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 362948005253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948005254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948005255 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 362948005256 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 362948005257 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 362948005258 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 362948005259 active site 362948005260 Zn binding site [ion binding]; other site 362948005261 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 362948005262 homodimer interface [polypeptide binding]; other site 362948005263 substrate-cofactor binding pocket; other site 362948005264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948005265 catalytic residue [active] 362948005266 Predicted integral membrane protein [Function unknown]; Region: COG5658 362948005267 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 362948005268 SdpI/YhfL protein family; Region: SdpI; pfam13630 362948005269 Similar to pyridoxine kinase; nonfunctional due to frameshift 362948005270 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 362948005271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 362948005272 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 362948005273 Amidinotransferase; Region: Amidinotransf; cl19186 362948005274 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362948005275 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 362948005276 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 362948005277 FtsX-like permease family; Region: FtsX; pfam02687 362948005278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 362948005279 FtsX-like permease family; Region: FtsX; pfam02687 362948005280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 362948005281 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362948005282 Walker A/P-loop; other site 362948005283 ATP binding site [chemical binding]; other site 362948005284 Q-loop/lid; other site 362948005285 ABC transporter signature motif; other site 362948005286 Walker B; other site 362948005287 D-loop; other site 362948005288 H-loop/switch region; other site 362948005289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948005290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948005291 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 362948005292 Haemolysin E (HlyE); Region: HlyE; cl11627 362948005293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 362948005294 active site 362948005295 metal binding site [ion binding]; metal-binding site 362948005296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948005297 active site 362948005298 catalytic tetrad [active] 362948005299 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 362948005300 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 362948005301 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 362948005302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362948005303 Walker A/P-loop; other site 362948005304 ATP binding site [chemical binding]; other site 362948005305 Q-loop/lid; other site 362948005306 ABC transporter signature motif; other site 362948005307 Walker B; other site 362948005308 D-loop; other site 362948005309 H-loop/switch region; other site 362948005310 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 362948005311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005312 putative substrate translocation pore; other site 362948005313 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 362948005314 dimer interface [polypeptide binding]; other site 362948005315 catalytic triad [active] 362948005316 peroxidatic and resolving cysteines [active] 362948005317 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 362948005318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362948005319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362948005320 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 362948005321 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 362948005322 LytTr DNA-binding domain; Region: LytTR; smart00850 362948005323 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 362948005324 S-methylmethionine transporter; Provisional; Region: PRK11387 362948005325 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948005326 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 362948005327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 362948005328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362948005329 Walker A/P-loop; other site 362948005330 ATP binding site [chemical binding]; other site 362948005331 Q-loop/lid; other site 362948005332 ABC transporter signature motif; other site 362948005333 Walker B; other site 362948005334 D-loop; other site 362948005335 H-loop/switch region; other site 362948005336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362948005337 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 362948005338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362948005339 Walker A/P-loop; other site 362948005340 ATP binding site [chemical binding]; other site 362948005341 Q-loop/lid; other site 362948005342 ABC transporter signature motif; other site 362948005343 Walker B; other site 362948005344 D-loop; other site 362948005345 H-loop/switch region; other site 362948005346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362948005347 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 362948005348 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362948005349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948005350 dimer interface [polypeptide binding]; other site 362948005351 conserved gate region; other site 362948005352 putative PBP binding loops; other site 362948005353 ABC-ATPase subunit interface; other site 362948005354 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 362948005355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362948005356 dimer interface [polypeptide binding]; other site 362948005357 conserved gate region; other site 362948005358 putative PBP binding loops; other site 362948005359 ABC-ATPase subunit interface; other site 362948005360 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 362948005361 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 362948005362 peptide binding site [polypeptide binding]; other site 362948005363 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 362948005364 elongation factor P; Validated; Region: PRK00529 362948005365 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 362948005366 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 362948005367 RNA binding site [nucleotide binding]; other site 362948005368 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 362948005369 RNA binding site [nucleotide binding]; other site 362948005370 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 362948005371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948005372 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 362948005373 active site 362948005374 motif I; other site 362948005375 motif II; other site 362948005376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362948005377 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362948005378 catalytic core [active] 362948005379 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 362948005380 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948005381 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 362948005382 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 362948005383 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 362948005384 glycerate kinase; Region: TIGR00045 362948005385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362948005386 dimerization interface [polypeptide binding]; other site 362948005387 putative DNA binding site [nucleotide binding]; other site 362948005388 putative Zn2+ binding site [ion binding]; other site 362948005389 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 362948005390 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 362948005391 potential catalytic triad [active] 362948005392 conserved cys residue [active] 362948005393 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 362948005394 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 362948005395 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 362948005396 putative active site [active] 362948005397 catalytic site [active] 362948005398 putative metal binding site [ion binding]; other site 362948005399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362948005400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362948005401 DNA binding site [nucleotide binding] 362948005402 domain linker motif; other site 362948005403 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 362948005404 dimerization interface [polypeptide binding]; other site 362948005405 ligand binding site [chemical binding]; other site 362948005406 sodium binding site [ion binding]; other site 362948005407 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 362948005408 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 362948005409 Ca binding site [ion binding]; other site 362948005410 active site 362948005411 catalytic site [active] 362948005412 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 362948005413 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 362948005414 active pocket/dimerization site; other site 362948005415 active site 362948005416 phosphorylation site [posttranslational modification] 362948005417 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 362948005418 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 362948005419 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 362948005420 active site 362948005421 phosphorylation site [posttranslational modification] 362948005422 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 362948005423 proposed active site lysine [active] 362948005424 conserved cys residue [active] 362948005425 cysteine synthase; Region: PLN02565 362948005426 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 362948005427 dimer interface [polypeptide binding]; other site 362948005428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948005429 catalytic residue [active] 362948005430 Similar to oligopeptide-binding protein oppA; nonfunctional due to truncation 362948005431 Similar to nitro/flavin reductase; nonfunctional due to truncation 362948005432 hypothetical protein; Validated; Region: PRK02101 362948005433 CAAX protease self-immunity; Region: Abi; pfam02517 362948005434 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 362948005435 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 362948005436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948005437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362948005438 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 362948005439 GDP-binding site [chemical binding]; other site 362948005440 ACT binding site; other site 362948005441 IMP binding site; other site 362948005442 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 362948005443 replicative DNA helicase; Provisional; Region: PRK05748 362948005444 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 362948005445 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 362948005446 Walker A motif; other site 362948005447 ATP binding site [chemical binding]; other site 362948005448 Walker B motif; other site 362948005449 DNA binding loops [nucleotide binding] 362948005450 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 362948005451 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 362948005452 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 362948005453 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 362948005454 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 362948005455 PAS domain; Region: PAS_8; pfam13188 362948005456 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 362948005457 DHH family; Region: DHH; pfam01368 362948005458 DHHA1 domain; Region: DHHA1; pfam02272 362948005459 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 362948005460 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 362948005461 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 362948005462 putative active site [active] 362948005463 putative metal binding site [ion binding]; other site 362948005464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948005465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948005466 LysR substrate binding domain; Region: LysR_substrate; pfam03466 362948005467 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 362948005468 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 362948005469 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 362948005470 Nucleoside recognition; Region: Gate; pfam07670 362948005471 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 362948005472 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 362948005473 ribonuclease P; Reviewed; Region: rnpA; PRK00499 362948005474 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 362948005475 UNKNOWN FEATURE KEY Comment; Source DNA is available from Eva McArdle at Alimentary Pharmabiotic Centre (e.mcardle@ucc.ie) 362948005476 Initiator Replication protein; Region: Rep_3; pfam01051 362948005477 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 362948005478 Similar to 6-phospho-beta-glucosidase; nonfunctional due to frameshift 362948005479 Similar to PTS system, beta-glucoside-specific IIABC component; nonfunctional due to truncation 362948005480 Similar to beta-glucoside operon antiterminator; nonfunctional due to truncation 362948005481 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 362948005482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 362948005483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 362948005484 P-loop; other site 362948005485 Magnesium ion binding site [ion binding]; other site 362948005486 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 362948005487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 362948005488 Probable transposase; Region: OrfB_IS605; pfam01385 362948005489 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 362948005490 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 362948005491 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 362948005492 Zn binding site [ion binding]; other site 362948005493 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 362948005494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362948005495 active site 362948005496 catalytic tetrad [active] 362948005497 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 362948005498 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 362948005499 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 362948005500 catalytic Zn binding site [ion binding]; other site 362948005501 NAD binding site [chemical binding]; other site 362948005502 structural Zn binding site [ion binding]; other site 362948005503 Predicted membrane protein [Function unknown]; Region: COG2364 362948005504 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362948005505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362948005506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362948005507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362948005508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005509 putative substrate translocation pore; other site 362948005510 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 362948005511 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 362948005512 N- and C-terminal domain interface [polypeptide binding]; other site 362948005513 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 362948005514 active site 362948005515 putative catalytic site [active] 362948005516 metal binding site [ion binding]; metal-binding site 362948005517 ATP binding site [chemical binding]; other site 362948005518 carbohydrate binding site [chemical binding]; other site 362948005519 Domain of unknown function (DUF718); Region: DUF718; cl01281 362948005520 L-rhamnose isomerase; Provisional; Region: PRK01076 362948005521 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 362948005522 intersubunit interface [polypeptide binding]; other site 362948005523 active site 362948005524 Zn2+ binding site [ion binding]; other site 362948005525 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948005526 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948005527 Int/Topo IB signature motif; other site 362948005528 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948005529 N-terminal C2 in EEIG1 and EHBP1 proteins; Region: NT-C2; pfam10358 362948005530 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 362948005531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 362948005532 Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift 362948005533 Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift 362948005534 Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift 362948005535 DEAD-like helicases superfamily; Region: DEXDc; smart00487 362948005536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362948005537 ATP binding site [chemical binding]; other site 362948005538 putative Mg++ binding site [ion binding]; other site 362948005539 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 362948005540 Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]; Region: COG5647 362948005541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948005542 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 362948005543 Walker A motif; other site 362948005544 ATP binding site [chemical binding]; other site 362948005545 Walker B motif; other site 362948005546 arginine finger; other site 362948005547 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 362948005548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948005549 Walker A motif; other site 362948005550 ATP binding site [chemical binding]; other site 362948005551 Walker B motif; other site 362948005552 arginine finger; other site 362948005553 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 362948005554 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 362948005555 amino acid transporter; Region: 2A0306; TIGR00909 362948005556 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 362948005557 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 362948005558 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 362948005559 hexamer interface [polypeptide binding]; other site 362948005560 ligand binding site [chemical binding]; other site 362948005561 putative active site [active] 362948005562 NAD(P) binding site [chemical binding]; other site 362948005563 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 362948005564 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 362948005565 EDD domain protein, DegV family; Region: DegV; TIGR00762 362948005566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362948005567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362948005568 Coenzyme A binding pocket [chemical binding]; other site 362948005569 histone-like DNA-binding protein HU; Region: HU; cd13831 362948005570 dimer interface [polypeptide binding]; other site 362948005571 DNA binding site [nucleotide binding] 362948005572 Similar to endopeptidase lactocepin; nonfunctional due to frameshift 362948005573 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 362948005574 FAD binding pocket [chemical binding]; other site 362948005575 conserved FAD binding motif [chemical binding]; other site 362948005576 phosphate binding motif [ion binding]; other site 362948005577 beta-alpha-beta structure motif; other site 362948005578 NAD binding pocket [chemical binding]; other site 362948005579 Transposase IS200 like; Region: Y1_Tnp; pfam01797 362948005580 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 362948005581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 362948005582 Probable transposase; Region: OrfB_IS605; pfam01385 362948005583 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 362948005584 Ferritin-like domain; Region: Ferritin; pfam00210 362948005585 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 362948005586 dimerization interface [polypeptide binding]; other site 362948005587 DPS ferroxidase diiron center [ion binding]; other site 362948005588 ion pore; other site 362948005589 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 362948005590 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 362948005591 ligand binding site [chemical binding]; other site 362948005592 flexible hinge region; other site 362948005593 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 362948005594 putative switch regulator; other site 362948005595 non-specific DNA interactions [nucleotide binding]; other site 362948005596 DNA binding site [nucleotide binding] 362948005597 sequence specific DNA binding site [nucleotide binding]; other site 362948005598 putative cAMP binding site [chemical binding]; other site 362948005599 Similar to transposase ISLasa6b, IS3 family; nonfunctional due to truncation 362948005600 Similar to transposase ISLasa13, IS6 family; nonfunctional due to frameshift 362948005601 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 362948005602 metal-binding site [ion binding] 362948005603 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 362948005604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362948005605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 362948005606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948005607 Transposase; Region: HTH_Tnp_1; cl17663 362948005608 putative transposase OrfB; Reviewed; Region: PHA02517 362948005609 HTH-like domain; Region: HTH_21; pfam13276 362948005610 Integrase core domain; Region: rve; pfam00665 362948005611 Integrase core domain; Region: rve_3; pfam13683 362948005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948005614 putative substrate translocation pore; other site 362948005615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362948005617 putative substrate translocation pore; other site 362948005618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362948005619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362948005620 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 362948005621 putative dimerization interface [polypeptide binding]; other site 362948005622 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 362948005623 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 362948005624 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 362948005625 classical (c) SDRs; Region: SDR_c; cd05233 362948005626 NAD(P) binding site [chemical binding]; other site 362948005627 active site 362948005628 FMN-binding domain; Region: FMN_bind; cl01081 362948005629 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 362948005630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 362948005631 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 362948005632 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 362948005633 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 362948005634 shikimate binding site; other site 362948005635 NAD(P) binding site [chemical binding]; other site 362948005636 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 362948005637 active site 362948005638 catalytic residue [active] 362948005639 dimer interface [polypeptide binding]; other site 362948005640 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 362948005641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362948005642 active site 362948005643 DNA binding site [nucleotide binding] 362948005644 Int/Topo IB signature motif; other site 362948005645 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 362948005646 active site 362948005647 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 362948005648 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 362948005649 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 362948005650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362948005651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948005652 active site 362948005653 phosphorylation site [posttranslational modification] 362948005654 intermolecular recognition site; other site 362948005655 dimerization interface [polypeptide binding]; other site 362948005656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362948005657 DNA binding residues [nucleotide binding] 362948005658 dimerization interface [polypeptide binding]; other site 362948005659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 362948005660 Histidine kinase; Region: HisKA_3; pfam07730 362948005661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362948005662 ATP binding site [chemical binding]; other site 362948005663 Mg2+ binding site [ion binding]; other site 362948005664 G-X-G motif; other site 362948005665 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362948005666 ABC-2 type transporter; Region: ABC2_membrane; cl17235 362948005667 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362948005668 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362948005669 Walker A/P-loop; other site 362948005670 ATP binding site [chemical binding]; other site 362948005671 Q-loop/lid; other site 362948005672 ABC transporter signature motif; other site 362948005673 Walker B; other site 362948005674 D-loop; other site 362948005675 H-loop/switch region; other site 362948005676 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 362948005677 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362948005678 active site 362948005679 dimer interface [polypeptide binding]; other site 362948005680 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 362948005681 substrate binding site [chemical binding]; other site 362948005682 hexamer interface [polypeptide binding]; other site 362948005683 metal binding site [ion binding]; metal-binding site 362948005684 Similar to DNA integration/recombination/inversion protein; nonfunctional due to frameshift 362948005685 CHAP domain; Region: CHAP; cl17642 362948005686 AAA-like domain; Region: AAA_10; pfam12846 362948005687 NTPase; Region: NTPase_1; cl17478 362948005688 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 362948005689 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 362948005690 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 362948005691 Walker A motif; other site 362948005692 ATP binding site [chemical binding]; other site 362948005693 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 362948005694 Walker B motif; other site 362948005695 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 362948005696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948005697 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 362948005698 Walker A motif; other site 362948005699 ATP binding site [chemical binding]; other site 362948005700 Walker B motif; other site 362948005701 arginine finger; other site 362948005702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362948005703 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 362948005704 Walker A motif; other site 362948005705 ATP binding site [chemical binding]; other site 362948005706 Walker B motif; other site 362948005707 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362948005708 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 362948005709 active site 362948005710 putative interdomain interaction site [polypeptide binding]; other site 362948005711 putative metal-binding site [ion binding]; other site 362948005712 putative nucleotide binding site [chemical binding]; other site 362948005713 DNA topoisomerase; Region: Topoisom_bac; pfam01131 362948005714 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 362948005715 domain I; other site 362948005716 DNA binding groove [nucleotide binding] 362948005717 phosphate binding site [ion binding]; other site 362948005718 domain II; other site 362948005719 domain III; other site 362948005720 nucleotide binding site [chemical binding]; other site 362948005721 catalytic site [active] 362948005722 domain IV; other site 362948005723 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 362948005724 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 362948005725 active site 362948005726 metal binding site [ion binding]; metal-binding site 362948005727 interdomain interaction site; other site 362948005728 MAEBL; Provisional; Region: PTZ00121 362948005729 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948005730 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362948005731 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 362948005732 PIN domain; Region: PIN_3; pfam13470 362948005733 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 362948005734 Similar to surface protein antigen precursor SapA; nonfunctional due to truncation 362948005735 Glucan-binding protein C; Region: GbpC; pfam08363 362948005736 Similar to conserved hypothetical protein; nonfunctional due to truncation 362948005737 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362948005738 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 362948005739 Int/Topo IB signature motif; other site 362948005740 Fic family protein [Function unknown]; Region: COG3177 362948005741 Fic/DOC family; Region: Fic; pfam02661 362948005742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005743 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948005744 non-specific DNA binding site [nucleotide binding]; other site 362948005745 salt bridge; other site 362948005746 sequence-specific DNA binding site [nucleotide binding]; other site 362948005747 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 362948005748 K+ potassium transporter; Region: K_trans; cl15781 362948005749 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 362948005750 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 362948005751 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948005752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005753 non-specific DNA binding site [nucleotide binding]; other site 362948005754 salt bridge; other site 362948005755 sequence-specific DNA binding site [nucleotide binding]; other site 362948005756 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 362948005757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948005759 non-specific DNA binding site [nucleotide binding]; other site 362948005760 salt bridge; other site 362948005761 sequence-specific DNA binding site [nucleotide binding]; other site 362948005762 Similar to conserved hypothetical protein; nonfunctional due to frameshift 362948005763 Similar to hypothetical protein; nonfunctional due to frameshift 362948005764 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 362948005765 catalytic residues [active] 362948005766 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 362948005767 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362948005768 catalytic residues [active] 362948005769 Similar to hypothetical protein; nonfunctional due to truncation 362948005770 Similar to replication protein; nonfunctional due to truncation 362948005771 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 362948005772 Arc-like DNA binding domain; Region: Arc; pfam03869 362948005773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005774 non-specific DNA binding site [nucleotide binding]; other site 362948005775 salt bridge; other site 362948005776 sequence-specific DNA binding site [nucleotide binding]; other site 362948005777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005778 non-specific DNA binding site [nucleotide binding]; other site 362948005779 salt bridge; other site 362948005780 sequence-specific DNA binding site [nucleotide binding]; other site 362948005781 Fic/DOC family; Region: Fic; pfam02661 362948005782 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 362948005783 Mg binding site [ion binding]; other site 362948005784 nucleotide binding site [chemical binding]; other site 362948005785 putative protofilament interface [polypeptide binding]; other site 362948005786 HrpJ-like domain; Region: HrpJ; cl15454 362948005787 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 362948005788 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 362948005789 active site 362948005790 nucleophile elbow; other site 362948005791 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 362948005792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362948005793 FeS/SAM binding site; other site 362948005794 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 362948005795 Pyruvate formate lyase 1; Region: PFL1; cd01678 362948005796 coenzyme A binding site [chemical binding]; other site 362948005797 active site 362948005798 catalytic residues [active] 362948005799 glycine loop; other site 362948005800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362948005801 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 362948005802 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362948005803 CCC1-related family of proteins; Region: CCC1_like; cl00278 362948005804 Similar to transposase ISLasa16, ISNCY family; nonfunctional due to interrupting stop codon 362948005805 FeS assembly protein SufB; Region: sufB; TIGR01980 362948005806 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 362948005807 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 362948005808 trimerization site [polypeptide binding]; other site 362948005809 active site 362948005810 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 362948005811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362948005812 catalytic residue [active] 362948005813 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 362948005814 FeS assembly protein SufD; Region: sufD; TIGR01981 362948005815 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 362948005816 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 362948005817 Walker A/P-loop; other site 362948005818 ATP binding site [chemical binding]; other site 362948005819 Q-loop/lid; other site 362948005820 ABC transporter signature motif; other site 362948005821 Walker B; other site 362948005822 D-loop; other site 362948005823 H-loop/switch region; other site 362948005824 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 362948005825 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 362948005826 peptide binding site [polypeptide binding]; other site 362948005827 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 362948005828 Cl- selectivity filter; other site 362948005829 Cl- binding residues [ion binding]; other site 362948005830 pore gating glutamate residue; other site 362948005831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362948005832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362948005833 non-specific DNA binding site [nucleotide binding]; other site 362948005834 salt bridge; other site 362948005835 sequence-specific DNA binding site [nucleotide binding]; other site 362948005836 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 362948005837 D-lactate dehydrogenase; Validated; Region: PRK08605 362948005838 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 362948005839 homodimer interface [polypeptide binding]; other site 362948005840 ligand binding site [chemical binding]; other site 362948005841 NAD binding site [chemical binding]; other site 362948005842 catalytic site [active] 362948005843 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 362948005844 active site 362948005845 intersubunit interactions; other site 362948005846 catalytic residue [active] 362948005847 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 362948005848 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 362948005849 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 362948005850 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 362948005851 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 362948005852 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 362948005853 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 362948005854 Mga helix-turn-helix domain; Region: Mga; pfam05043 362948005855 PRD domain; Region: PRD; pfam00874 362948005856 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 362948005857 active site 362948005858 phosphorylation site [posttranslational modification] 362948005859 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 362948005860 classical (c) SDRs; Region: SDR_c; cd05233 362948005861 NAD(P) binding site [chemical binding]; other site 362948005862 active site 362948005863 Similar to phage protein; nonfunctional due to frameshift and truncation 362948005864 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 362948005865 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 362948005866 Putative toxin 64; Region: Toxin_64; pfam15542 362948005867 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 362948005868 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 362948005869 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 362948005870 FMN binding site [chemical binding]; other site 362948005871 substrate binding site [chemical binding]; other site 362948005872 putative catalytic residue [active] 362948005873 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 362948005874 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 362948005875 putative catalytic cysteine [active] 362948005876 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 362948005877 putative active site [active] 362948005878 metal binding site [ion binding]; metal-binding site 362948005879 Similar to hypothetical surface protein; nonfunctional due to truncation 362948005880 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 362948005881 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 362948005882 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 362948005883 HlyD family secretion protein; Region: HlyD_3; pfam13437 362948005884 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 362948005885 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 362948005886 putative active site [active] 362948005887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362948005888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362948005889 Walker A/P-loop; other site 362948005890 ATP binding site [chemical binding]; other site 362948005891 Q-loop/lid; other site 362948005892 ABC transporter signature motif; other site 362948005893 Walker B; other site 362948005894 D-loop; other site 362948005895 H-loop/switch region; other site 362948005896 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 362948005897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362948005898 active site 362948005899 phosphorylation site [posttranslational modification] 362948005900 intermolecular recognition site; other site 362948005901 dimerization interface [polypeptide binding]; other site 362948005902 LytTr DNA-binding domain; Region: LytTR; pfam04397 362948005903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 362948005904 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 362948005905 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 362948005906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362948005907 catalytic residues [active] 362948005908 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 362948005909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362948005910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362948005911 homodimer interface [polypeptide binding]; other site 362948005912 catalytic residue [active] 362948005913 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 362948005914 putative active site [active] 362948005915 catalytic triad [active] 362948005916 putative dimer interface [polypeptide binding]; other site 362948005917 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 362948005918 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 362948005919 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 362948005920 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 362948005921 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 362948005922 Similar to sialidase; nonfunctional due to frameshift and truncation 362948005923 MFS/sugar transport protein; Region: MFS_2; pfam13347 362948005924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362948005925 putative substrate translocation pore; other site 362948005926 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362948005927 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362948005928 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362948005929 Domain of unknown function (DUF386); Region: DUF386; cl01047 362948005930 Nucleoside diphosphate kinase; Region: NDK; pfam00334 362948005931 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 362948005932 active site 362948005933 multimer interface [polypeptide binding]; other site 362948005934 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 362948005935 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362948005936 nucleotide binding site [chemical binding]; other site 362948005937 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 362948005938 inhibitor site; inhibition site 362948005939 active site 362948005940 dimer interface [polypeptide binding]; other site 362948005941 catalytic residue [active] 362948005942 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 362948005943 putative active site cavity [active] 362948005944 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 362948005945 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362948005946 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362948005947 putative active site [active] 362948005948 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362948005949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362948005950 NAD(P) binding site [chemical binding]; other site 362948005951 active site 362948005952 inner membrane transporter YjeM; Provisional; Region: PRK15238 362948005953 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 362948005954 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362948005955 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 362948005956 G1 box; other site 362948005957 GTP/Mg2+ binding site [chemical binding]; other site 362948005958 G2 box; other site 362948005959 Switch I region; other site 362948005960 G3 box; other site 362948005961 Switch II region; other site 362948005962 G4 box; other site 362948005963 G5 box; other site 362948005964 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 362948005965 Elongation Factor G, domain II; Region: EFG_II; pfam14492 362948005966 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 362948005967 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 362948005968 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 362948005969 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 362948005970 TPP-binding site [chemical binding]; other site 362948005971 dimer interface [polypeptide binding]; other site 362948005972 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362948005973 PYR/PP interface [polypeptide binding]; other site 362948005974 dimer interface [polypeptide binding]; other site 362948005975 TPP binding site [chemical binding]; other site 362948005976 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362948005977 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 362948005978 active site 362948005979 intersubunit interactions; other site 362948005980 catalytic residue [active] 362948005981 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 362948005982 substrate binding site [chemical binding]; other site 362948005983 hexamer interface [polypeptide binding]; other site 362948005984 metal binding site [ion binding]; metal-binding site 362948005985 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 362948005986 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 362948005987 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 362948005988 active site 362948005989 phosphorylation site [posttranslational modification] 362948005990 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362948005991 active pocket/dimerization site; other site 362948005992 active site 362948005993 phosphorylation site [posttranslational modification] 362948005994 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 362948005995 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362948005996 putative NAD(P) binding site [chemical binding]; other site 362948005997 putative catalytic Zn binding site [ion binding]; other site 362948005998 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362948005999 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362948006000 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362948006001 putative phosphoketolase; Provisional; Region: PRK05261 362948006002 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 362948006003 TPP-binding site; other site 362948006004 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 362948006005 XFP C-terminal domain; Region: XFP_C; pfam09363 362948006006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 362948006007 HTH-like domain; Region: HTH_21; pfam13276 362948006008 Integrase core domain; Region: rve; pfam00665 362948006009 Integrase core domain; Region: rve_3; cl15866 362948006010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948006011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362948006012 Transposase; Region: HTH_Tnp_1; cl17663