-- dump date 20140619_125101 -- class Genbank::misc_feature -- table misc_feature_note -- id note 714313000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 714313000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 714313000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313000004 Walker A motif; other site 714313000005 ATP binding site [chemical binding]; other site 714313000006 Walker B motif; other site 714313000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 714313000008 arginine finger; other site 714313000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 714313000010 DnaA box-binding interface [nucleotide binding]; other site 714313000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 714313000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714313000013 putative DNA binding surface [nucleotide binding]; other site 714313000014 dimer interface [polypeptide binding]; other site 714313000015 beta-clamp/clamp loader binding surface; other site 714313000016 beta-clamp/translesion DNA polymerase binding surface; other site 714313000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 714313000018 recombination protein F; Reviewed; Region: recF; PRK00064 714313000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 714313000020 Walker A/P-loop; other site 714313000021 ATP binding site [chemical binding]; other site 714313000022 Q-loop/lid; other site 714313000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000024 ABC transporter signature motif; other site 714313000025 Walker B; other site 714313000026 D-loop; other site 714313000027 H-loop/switch region; other site 714313000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 714313000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714313000030 Mg2+ binding site [ion binding]; other site 714313000031 G-X-G motif; other site 714313000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714313000033 anchoring element; other site 714313000034 dimer interface [polypeptide binding]; other site 714313000035 ATP binding site [chemical binding]; other site 714313000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714313000037 active site 714313000038 putative metal-binding site [ion binding]; other site 714313000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714313000040 DNA gyrase subunit A; Validated; Region: PRK05560 714313000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714313000042 CAP-like domain; other site 714313000043 active site 714313000044 primary dimer interface [polypeptide binding]; other site 714313000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 714313000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 714313000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 714313000054 dimer interface [polypeptide binding]; other site 714313000055 ssDNA binding site [nucleotide binding]; other site 714313000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 714313000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 714313000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714313000060 DHH family; Region: DHH; pfam01368 714313000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 714313000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 714313000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 714313000064 replicative DNA helicase; Region: DnaB; TIGR00665 714313000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714313000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714313000067 Walker A motif; other site 714313000068 ATP binding site [chemical binding]; other site 714313000069 Walker B motif; other site 714313000070 DNA binding loops [nucleotide binding] 714313000071 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714313000072 EamA-like transporter family; Region: EamA; pfam00892 714313000073 EamA-like transporter family; Region: EamA; pfam00892 714313000074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714313000075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714313000076 active site 714313000077 phosphorylation site [posttranslational modification] 714313000078 intermolecular recognition site; other site 714313000079 dimerization interface [polypeptide binding]; other site 714313000080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714313000081 DNA binding site [nucleotide binding] 714313000082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 714313000083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714313000084 dimerization interface [polypeptide binding]; other site 714313000085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714313000086 putative active site [active] 714313000087 heme pocket [chemical binding]; other site 714313000088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714313000089 dimer interface [polypeptide binding]; other site 714313000090 phosphorylation site [posttranslational modification] 714313000091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714313000092 ATP binding site [chemical binding]; other site 714313000093 Mg2+ binding site [ion binding]; other site 714313000094 G-X-G motif; other site 714313000095 YycH protein; Region: YycH; pfam07435 714313000096 YycH protein; Region: YycI; pfam09648 714313000097 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 714313000098 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 714313000099 YibE/F-like protein; Region: YibE_F; pfam07907 714313000100 YibE/F-like protein; Region: YibE_F; pfam07907 714313000101 hypothetical protein; Provisional; Region: PRK10621 714313000102 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714313000103 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 714313000104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313000106 putative substrate translocation pore; other site 714313000107 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714313000108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714313000109 Walker A/P-loop; other site 714313000110 ATP binding site [chemical binding]; other site 714313000111 Q-loop/lid; other site 714313000112 ABC transporter signature motif; other site 714313000113 Walker B; other site 714313000114 D-loop; other site 714313000115 H-loop/switch region; other site 714313000116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714313000117 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714313000118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714313000119 Walker A/P-loop; other site 714313000120 ATP binding site [chemical binding]; other site 714313000121 Q-loop/lid; other site 714313000122 ABC transporter signature motif; other site 714313000123 Walker B; other site 714313000124 D-loop; other site 714313000125 H-loop/switch region; other site 714313000126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714313000127 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714313000128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313000129 dimer interface [polypeptide binding]; other site 714313000130 conserved gate region; other site 714313000131 putative PBP binding loops; other site 714313000132 ABC-ATPase subunit interface; other site 714313000133 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 714313000134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313000135 putative PBP binding loops; other site 714313000136 ABC-ATPase subunit interface; other site 714313000137 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 714313000138 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 714313000139 peptide binding site [polypeptide binding]; other site 714313000140 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 714313000141 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 714313000142 Zn binding site [ion binding]; other site 714313000143 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714313000144 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714313000145 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714313000146 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714313000147 active site 714313000148 metal binding site [ion binding]; metal-binding site 714313000149 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714313000150 benzoate transport; Region: 2A0115; TIGR00895 714313000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000152 putative substrate translocation pore; other site 714313000153 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714313000154 hypothetical protein; Provisional; Region: PRK10621 714313000155 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714313000156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714313000157 Predicted flavoprotein [General function prediction only]; Region: COG0431 714313000158 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 714313000159 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714313000160 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714313000161 aspartate kinase; Reviewed; Region: PRK09034 714313000162 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 714313000163 putative catalytic residues [active] 714313000164 putative nucleotide binding site [chemical binding]; other site 714313000165 putative aspartate binding site [chemical binding]; other site 714313000166 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 714313000167 allosteric regulatory residue; other site 714313000168 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714313000169 diaminopimelate decarboxylase; Region: lysA; TIGR01048 714313000170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 714313000171 active site 714313000172 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714313000173 substrate binding site [chemical binding]; other site 714313000174 catalytic residues [active] 714313000175 dimer interface [polypeptide binding]; other site 714313000176 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 714313000177 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 714313000178 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 714313000179 active site 714313000180 trimer interface [polypeptide binding]; other site 714313000181 substrate binding site [chemical binding]; other site 714313000182 CoA binding site [chemical binding]; other site 714313000183 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714313000184 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 714313000185 metal binding site [ion binding]; metal-binding site 714313000186 putative dimer interface [polypeptide binding]; other site 714313000187 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 714313000188 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 714313000189 dimer interface [polypeptide binding]; other site 714313000190 active site 714313000191 catalytic residue [active] 714313000192 dihydrodipicolinate reductase; Provisional; Region: PRK00048 714313000193 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 714313000194 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 714313000195 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 714313000196 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714313000197 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 714313000198 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 714313000199 catalytic triad [active] 714313000200 catalytic triad [active] 714313000201 oxyanion hole [active] 714313000202 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 714313000203 amino acid transporter; Region: 2A0306; TIGR00909 714313000204 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714313000205 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 714313000206 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 714313000207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714313000208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714313000209 Walker A/P-loop; other site 714313000210 ATP binding site [chemical binding]; other site 714313000211 Q-loop/lid; other site 714313000212 ABC transporter signature motif; other site 714313000213 Walker B; other site 714313000214 D-loop; other site 714313000215 H-loop/switch region; other site 714313000216 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714313000217 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714313000218 FtsX-like permease family; Region: FtsX; pfam02687 714313000219 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 714313000220 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 714313000221 catalytic triad [active] 714313000222 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714313000223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714313000224 active site 714313000225 Int/Topo IB signature motif; other site 714313000226 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714313000227 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714313000228 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 714313000229 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 714313000230 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 714313000231 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714313000232 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 714313000233 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 714313000234 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 714313000235 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714313000236 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714313000237 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714313000238 TrkA-N domain; Region: TrkA_N; pfam02254 714313000239 TrkA-C domain; Region: TrkA_C; pfam02080 714313000240 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 714313000241 PemK-like protein; Region: PemK; pfam02452 714313000242 multicopper oxidase; Provisional; Region: PRK10965 714313000243 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 714313000244 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 714313000245 Predicted membrane protein [Function unknown]; Region: COG3601 714313000246 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 714313000247 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 714313000248 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 714313000249 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714313000250 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 714313000251 DNA binding residues [nucleotide binding] 714313000252 putative dimer interface [polypeptide binding]; other site 714313000253 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 714313000254 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714313000255 nudix motif; other site 714313000256 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 714313000257 D-lactate dehydrogenase; Validated; Region: PRK08605 714313000258 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 714313000259 homodimer interface [polypeptide binding]; other site 714313000260 ligand binding site [chemical binding]; other site 714313000261 NAD binding site [chemical binding]; other site 714313000262 catalytic site [active] 714313000263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714313000264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714313000265 homodimer interface [polypeptide binding]; other site 714313000266 catalytic residue [active] 714313000267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313000268 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714313000269 Coenzyme A binding pocket [chemical binding]; other site 714313000270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714313000271 MarR family; Region: MarR_2; pfam12802 714313000272 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 714313000273 peptidase T; Region: peptidase-T; TIGR01882 714313000274 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 714313000275 metal binding site [ion binding]; metal-binding site 714313000276 dimer interface [polypeptide binding]; other site 714313000277 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 714313000278 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714313000279 Domain of unknown function (DU1801); Region: DUF1801; cl17490 714313000280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000281 Homeodomain-like domain; Region: HTH_23; cl17451 714313000282 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000283 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 714313000284 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 714313000285 Na binding site [ion binding]; other site 714313000286 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 714313000287 CAAX protease self-immunity; Region: Abi; pfam02517 714313000288 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 714313000289 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714313000290 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 714313000291 intersubunit interface [polypeptide binding]; other site 714313000292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714313000293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714313000294 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714313000295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714313000296 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313000297 Walker A/P-loop; other site 714313000298 ATP binding site [chemical binding]; other site 714313000299 Q-loop/lid; other site 714313000300 ABC transporter signature motif; other site 714313000301 Walker B; other site 714313000302 D-loop; other site 714313000303 H-loop/switch region; other site 714313000304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313000305 Walker A/P-loop; other site 714313000306 ATP binding site [chemical binding]; other site 714313000307 ABC transporter; Region: ABC_tran; pfam00005 714313000308 Q-loop/lid; other site 714313000309 ABC transporter signature motif; other site 714313000310 Walker B; other site 714313000311 D-loop; other site 714313000312 H-loop/switch region; other site 714313000313 Predicted transcriptional regulators [Transcription]; Region: COG1733 714313000314 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714313000315 Predicted transcriptional regulators [Transcription]; Region: COG1733 714313000316 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313000317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313000318 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313000319 Probable transposase; Region: OrfB_IS605; pfam01385 714313000320 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313000321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 714313000322 putative substrate translocation pore; other site 714313000323 Predicted transcriptional regulators [Transcription]; Region: COG1733 714313000324 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714313000325 recombinase A; Provisional; Region: recA; PRK09354 714313000326 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 714313000327 hexamer interface [polypeptide binding]; other site 714313000328 Walker A motif; other site 714313000329 ATP binding site [chemical binding]; other site 714313000330 Walker B motif; other site 714313000331 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 714313000332 Predicted membrane protein [Function unknown]; Region: COG4392 714313000333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 714313000334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313000335 Coenzyme A binding pocket [chemical binding]; other site 714313000336 putative acyltransferase; Provisional; Region: PRK05790 714313000337 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714313000338 dimer interface [polypeptide binding]; other site 714313000339 active site 714313000340 potential frameshift: common BLAST hit: gi|254555475|ref|YP_003061892.1| transaminase 714313000341 transaminase; Reviewed; Region: PRK08068 714313000342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714313000343 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 714313000344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714313000345 homodimer interface [polypeptide binding]; other site 714313000346 catalytic residue [active] 714313000347 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 714313000348 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 714313000349 Walker A/P-loop; other site 714313000350 ATP binding site [chemical binding]; other site 714313000351 Q-loop/lid; other site 714313000352 ABC transporter signature motif; other site 714313000353 Walker B; other site 714313000354 D-loop; other site 714313000355 H-loop/switch region; other site 714313000356 NIL domain; Region: NIL; pfam09383 714313000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313000358 dimer interface [polypeptide binding]; other site 714313000359 conserved gate region; other site 714313000360 ABC-ATPase subunit interface; other site 714313000361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000362 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000363 putative transposase OrfB; Reviewed; Region: PHA02517 714313000364 HTH-like domain; Region: HTH_21; pfam13276 714313000365 Integrase core domain; Region: rve; pfam00665 714313000366 Integrase core domain; Region: rve_2; pfam13333 714313000367 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714313000368 Protein of unknown function, DUF488; Region: DUF488; cl01246 714313000369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000370 ABC transporter signature motif; other site 714313000371 Walker B; other site 714313000372 D-loop; other site 714313000373 H-loop/switch region; other site 714313000374 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313000375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313000376 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313000377 Probable transposase; Region: OrfB_IS605; pfam01385 714313000378 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313000379 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 714313000380 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714313000381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714313000382 acetoin reductase; Validated; Region: PRK08643 714313000383 NAD(P) binding site [chemical binding]; other site 714313000384 active site 714313000385 amino acid transporter; Region: 2A0306; TIGR00909 714313000386 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714313000387 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 714313000388 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714313000389 inhibitor-cofactor binding pocket; inhibition site 714313000390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714313000391 catalytic residue [active] 714313000392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000393 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714313000394 putative substrate translocation pore; other site 714313000395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313000397 putative substrate translocation pore; other site 714313000398 maltose phosphorylase; Provisional; Region: PRK13807 714313000399 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 714313000400 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 714313000401 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 714313000402 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 714313000403 active site 714313000404 catalytic residues [active] 714313000405 beta-phosphoglucomutase; Region: bPGM; TIGR01990 714313000406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313000407 motif II; other site 714313000408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000409 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000410 putative transposase OrfB; Reviewed; Region: PHA02517 714313000411 HTH-like domain; Region: HTH_21; pfam13276 714313000412 Integrase core domain; Region: rve; pfam00665 714313000413 Integrase core domain; Region: rve_2; pfam13333 714313000414 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714313000415 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 714313000416 Int/Topo IB signature motif; other site 714313000417 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000418 putative transposase OrfB; Reviewed; Region: PHA02517 714313000419 HTH-like domain; Region: HTH_21; pfam13276 714313000420 Integrase core domain; Region: rve; pfam00665 714313000421 Integrase core domain; Region: rve_2; pfam13333 714313000422 Bacterial sugar transferase; Region: Bac_transf; pfam02397 714313000423 Bacterial sugar transferase; Region: Bac_transf; cl00939 714313000424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714313000425 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714313000426 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 714313000427 Transposase, Mutator family; Region: Transposase_mut; pfam00872 714313000428 MULE transposase domain; Region: MULE; pfam10551 714313000429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714313000430 active site 714313000431 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 714313000432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714313000433 active site 714313000434 DDE domain; Region: DDE_Tnp_IS240; pfam13610 714313000435 Integrase core domain; Region: rve; pfam00665 714313000436 Integrase core domain; Region: rve_3; cl15866 714313000437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000438 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000439 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000440 Integrase core domain; Region: rve; pfam00665 714313000441 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714313000442 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 714313000443 Ca binding site [ion binding]; other site 714313000444 active site 714313000445 catalytic site [active] 714313000446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000449 Transposase; Region: HTH_Tnp_1; pfam01527 714313000450 GMP synthase; Reviewed; Region: guaA; PRK00074 714313000451 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 714313000452 AMP/PPi binding site [chemical binding]; other site 714313000453 candidate oxyanion hole; other site 714313000454 catalytic triad [active] 714313000455 potential glutamine specificity residues [chemical binding]; other site 714313000456 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 714313000457 ATP Binding subdomain [chemical binding]; other site 714313000458 Ligand Binding sites [chemical binding]; other site 714313000459 Dimerization subdomain; other site 714313000460 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 714313000461 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714313000462 active site 714313000463 histidyl-tRNA synthetase; Region: hisS; TIGR00442 714313000464 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 714313000465 dimer interface [polypeptide binding]; other site 714313000466 motif 1; other site 714313000467 active site 714313000468 motif 2; other site 714313000469 motif 3; other site 714313000470 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 714313000471 anticodon binding site; other site 714313000472 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714313000473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313000474 dimer interface [polypeptide binding]; other site 714313000475 conserved gate region; other site 714313000476 putative PBP binding loops; other site 714313000477 ABC-ATPase subunit interface; other site 714313000478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714313000479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000480 Walker A/P-loop; other site 714313000481 ATP binding site [chemical binding]; other site 714313000482 Q-loop/lid; other site 714313000483 ABC transporter signature motif; other site 714313000484 Walker B; other site 714313000485 D-loop; other site 714313000486 H-loop/switch region; other site 714313000487 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714313000488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714313000489 substrate binding pocket [chemical binding]; other site 714313000490 membrane-bound complex binding site; other site 714313000491 hinge residues; other site 714313000492 Homeodomain-like domain; Region: HTH_23; cl17451 714313000493 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000494 HTH-like domain; Region: HTH_21; pfam13276 714313000495 Integrase core domain; Region: rve; pfam00665 714313000496 Integrase core domain; Region: rve_2; pfam13333 714313000497 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 714313000498 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 714313000499 FAD binding site [chemical binding]; other site 714313000500 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313000501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313000502 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313000503 Probable transposase; Region: OrfB_IS605; pfam01385 714313000504 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313000505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714313000506 EDD domain protein, DegV family; Region: DegV; TIGR00762 714313000507 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714313000508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313000510 putative substrate translocation pore; other site 714313000511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714313000512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714313000513 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714313000514 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714313000515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000516 Walker A/P-loop; other site 714313000517 ATP binding site [chemical binding]; other site 714313000518 Q-loop/lid; other site 714313000519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000520 ABC transporter signature motif; other site 714313000521 Walker B; other site 714313000522 D-loop; other site 714313000523 H-loop/switch region; other site 714313000524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313000525 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714313000526 Walker A/P-loop; other site 714313000527 ATP binding site [chemical binding]; other site 714313000528 Q-loop/lid; other site 714313000529 ABC transporter signature motif; other site 714313000530 Walker B; other site 714313000531 D-loop; other site 714313000532 H-loop/switch region; other site 714313000533 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714313000534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714313000535 substrate binding pocket [chemical binding]; other site 714313000536 membrane-bound complex binding site; other site 714313000537 hinge residues; other site 714313000538 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 714313000539 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 714313000540 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 714313000541 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714313000542 Domain of unknown function DUF21; Region: DUF21; pfam01595 714313000543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714313000544 Transporter associated domain; Region: CorC_HlyC; smart01091 714313000545 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 714313000546 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714313000547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313000548 motif II; other site 714313000549 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313000550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313000551 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313000552 Probable transposase; Region: OrfB_IS605; pfam01385 714313000553 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313000554 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 714313000555 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 714313000556 putative catalytic cysteine [active] 714313000557 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 714313000558 putative active site [active] 714313000559 metal binding site [ion binding]; metal-binding site 714313000560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714313000561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714313000562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714313000563 dimerization interface [polypeptide binding]; other site 714313000564 malate dehydrogenase; Provisional; Region: PRK13529 714313000565 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714313000566 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 714313000567 NAD(P) binding site [chemical binding]; other site 714313000568 Membrane transport protein; Region: Mem_trans; cl09117 714313000569 DDE domain; Region: DDE_Tnp_IS240; pfam13610 714313000570 Integrase core domain; Region: rve; pfam00665 714313000571 Integrase core domain; Region: rve_3; pfam13683 714313000572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000573 Transposase; Region: HTH_Tnp_1; pfam01527 714313000574 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 714313000575 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 714313000576 active site 714313000577 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 714313000578 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 714313000579 Resolvase, N terminal domain; Region: Resolvase; pfam00239 714313000580 Homeodomain-like domain; Region: HTH_23; pfam13384 714313000581 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 714313000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714313000583 Zn2+ binding site [ion binding]; other site 714313000584 Mg2+ binding site [ion binding]; other site 714313000585 K+ potassium transporter; Region: K_trans; pfam02705 714313000586 Cadmium resistance transporter; Region: Cad; pfam03596 714313000587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714313000588 dimerization interface [polypeptide binding]; other site 714313000589 putative DNA binding site [nucleotide binding]; other site 714313000590 putative Zn2+ binding site [ion binding]; other site 714313000591 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 714313000592 putative deacylase active site [active] 714313000593 manganese transport protein MntH; Reviewed; Region: PRK00701 714313000594 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 714313000595 putative transposase OrfB; Reviewed; Region: PHA02517 714313000596 HTH-like domain; Region: HTH_21; pfam13276 714313000597 Integrase core domain; Region: rve; pfam00665 714313000598 Integrase core domain; Region: rve_2; pfam13333 714313000599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714313000600 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714313000601 DNA-binding site [nucleotide binding]; DNA binding site 714313000602 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 714313000603 putative phosphoketolase; Provisional; Region: PRK05261 714313000604 XFP N-terminal domain; Region: XFP_N; pfam09364 714313000605 XFP C-terminal domain; Region: XFP_C; pfam09363 714313000606 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714313000607 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714313000608 active site 714313000609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714313000610 Ligand Binding Site [chemical binding]; other site 714313000611 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 714313000612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714313000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714313000614 homodimer interface [polypeptide binding]; other site 714313000615 catalytic residue [active] 714313000616 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714313000617 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714313000618 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 714313000619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714313000620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714313000621 non-specific DNA binding site [nucleotide binding]; other site 714313000622 salt bridge; other site 714313000623 sequence-specific DNA binding site [nucleotide binding]; other site 714313000624 phosphodiesterase; Provisional; Region: PRK12704 714313000625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714313000626 Zn2+ binding site [ion binding]; other site 714313000627 Mg2+ binding site [ion binding]; other site 714313000628 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714313000629 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714313000630 active site 714313000631 metal binding site [ion binding]; metal-binding site 714313000632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714313000633 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 714313000634 ArsC family; Region: ArsC; pfam03960 714313000635 putative catalytic residues [active] 714313000636 thiol/disulfide switch; other site 714313000637 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714313000638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313000639 active site 714313000640 motif I; other site 714313000641 motif II; other site 714313000642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000643 Transposase; Region: HTH_Tnp_1; pfam01527 714313000644 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 714313000645 active site 714313000646 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 714313000647 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714313000648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714313000649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714313000650 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714313000651 Sulfatase; Region: Sulfatase; pfam00884 714313000652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000653 catalytic core [active] 714313000654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000655 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 714313000656 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714313000657 DNA binding residues [nucleotide binding] 714313000658 putative dimer interface [polypeptide binding]; other site 714313000659 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 714313000660 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 714313000661 Cl binding site [ion binding]; other site 714313000662 oligomer interface [polypeptide binding]; other site 714313000663 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 714313000664 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 714313000665 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714313000666 catalytic residues [active] 714313000667 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714313000668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714313000669 putative transposase OrfB; Reviewed; Region: PHA02517 714313000670 HTH-like domain; Region: HTH_21; pfam13276 714313000671 Integrase core domain; Region: rve; pfam00665 714313000672 Integrase core domain; Region: rve_3; pfam13683 714313000673 Transposase; Region: HTH_Tnp_1; pfam01527 714313000674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000675 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 714313000676 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 714313000677 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 714313000678 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 714313000679 active site 714313000680 HIGH motif; other site 714313000681 dimer interface [polypeptide binding]; other site 714313000682 KMSKS motif; other site 714313000683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313000684 RNA binding surface [nucleotide binding]; other site 714313000685 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 714313000686 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 714313000687 glycerol kinase; Provisional; Region: glpK; PRK00047 714313000688 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 714313000689 N- and C-terminal domain interface [polypeptide binding]; other site 714313000690 active site 714313000691 MgATP binding site [chemical binding]; other site 714313000692 catalytic site [active] 714313000693 metal binding site [ion binding]; metal-binding site 714313000694 glycerol binding site [chemical binding]; other site 714313000695 homotetramer interface [polypeptide binding]; other site 714313000696 homodimer interface [polypeptide binding]; other site 714313000697 FBP binding site [chemical binding]; other site 714313000698 protein IIAGlc interface [polypeptide binding]; other site 714313000699 Sugar transport protein; Region: Sugar_transport; pfam06800 714313000700 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 714313000701 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 714313000702 TRAM domain; Region: TRAM; pfam01938 714313000703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313000704 S-adenosylmethionine binding site [chemical binding]; other site 714313000705 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 714313000706 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 714313000707 Walker A/P-loop; other site 714313000708 ATP binding site [chemical binding]; other site 714313000709 Q-loop/lid; other site 714313000710 ABC transporter signature motif; other site 714313000711 Walker B; other site 714313000712 D-loop; other site 714313000713 H-loop/switch region; other site 714313000714 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 714313000715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714313000716 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714313000717 putative NAD(P) binding site [chemical binding]; other site 714313000718 amino acid transporter; Region: 2A0306; TIGR00909 714313000719 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 714313000720 Predicted membrane protein [Function unknown]; Region: COG2364 714313000721 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 714313000722 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714313000723 putative NAD(P) binding site [chemical binding]; other site 714313000724 catalytic Zn binding site [ion binding]; other site 714313000725 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714313000726 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 714313000727 substrate binding site [chemical binding]; other site 714313000728 dimer interface [polypeptide binding]; other site 714313000729 ATP binding site [chemical binding]; other site 714313000730 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 714313000731 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313000732 active site 714313000733 dimer interface [polypeptide binding]; other site 714313000734 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 714313000735 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 714313000736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313000737 Coenzyme A binding pocket [chemical binding]; other site 714313000738 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714313000739 active site 714313000740 EDD domain protein, DegV family; Region: DegV; TIGR00762 714313000741 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714313000742 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 714313000743 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 714313000744 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 714313000745 active site 714313000746 Zn binding site [ion binding]; other site 714313000747 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 714313000748 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 714313000749 Predicted membrane protein [Function unknown]; Region: COG2323 714313000750 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 714313000751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714313000752 metal binding site 2 [ion binding]; metal-binding site 714313000753 putative DNA binding helix; other site 714313000754 metal binding site 1 [ion binding]; metal-binding site 714313000755 dimer interface [polypeptide binding]; other site 714313000756 structural Zn2+ binding site [ion binding]; other site 714313000757 DEAD_2; Region: DEAD_2; pfam06733 714313000758 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 714313000759 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714313000760 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 714313000761 active site 714313000762 homotetramer interface [polypeptide binding]; other site 714313000763 homodimer interface [polypeptide binding]; other site 714313000764 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714313000765 Ligand Binding Site [chemical binding]; other site 714313000766 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 714313000767 substrate binding site [chemical binding]; other site 714313000768 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714313000769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714313000770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714313000771 active site 714313000772 metal binding site [ion binding]; metal-binding site 714313000773 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714313000774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313000775 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313000776 ABC transporter; Region: ABC_tran_2; pfam12848 714313000777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313000778 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714313000779 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 714313000780 active site 714313000781 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 714313000782 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 714313000783 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714313000784 Guanylate kinase; Region: Guanylate_kin; pfam00625 714313000785 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 714313000786 active site 714313000787 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714313000788 Nitronate monooxygenase; Region: NMO; pfam03060 714313000789 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 714313000790 FMN binding site [chemical binding]; other site 714313000791 substrate binding site [chemical binding]; other site 714313000792 putative catalytic residue [active] 714313000793 L-type amino acid transporter; Region: 2A0308; TIGR00911 714313000794 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 714313000795 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 714313000796 HflX GTPase family; Region: HflX; cd01878 714313000797 G1 box; other site 714313000798 GTP/Mg2+ binding site [chemical binding]; other site 714313000799 Switch I region; other site 714313000800 G2 box; other site 714313000801 G3 box; other site 714313000802 Switch II region; other site 714313000803 G4 box; other site 714313000804 G5 box; other site 714313000805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000806 catalytic core [active] 714313000807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000808 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714313000809 Part of AAA domain; Region: AAA_19; pfam13245 714313000810 Family description; Region: UvrD_C_2; pfam13538 714313000811 pantothenate kinase; Provisional; Region: PRK05439 714313000812 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 714313000813 ATP-binding site [chemical binding]; other site 714313000814 CoA-binding site [chemical binding]; other site 714313000815 Mg2+-binding site [ion binding]; other site 714313000816 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 714313000817 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 714313000818 Penicillinase repressor; Region: Pencillinase_R; pfam03965 714313000819 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 714313000820 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714313000821 Soluble P-type ATPase [General function prediction only]; Region: COG4087 714313000822 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714313000823 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714313000824 active site 714313000825 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 714313000826 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 714313000827 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 714313000828 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714313000829 putative transposase OrfB; Reviewed; Region: PHA02517 714313000830 HTH-like domain; Region: HTH_21; pfam13276 714313000831 Integrase core domain; Region: rve; pfam00665 714313000832 Integrase core domain; Region: rve_2; pfam13333 714313000833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000834 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313000836 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313000837 Uncharacterized conserved protein [Function unknown]; Region: COG2966 714313000838 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 714313000839 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 714313000840 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 714313000841 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 714313000842 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 714313000843 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714313000844 phosphate binding site [ion binding]; other site 714313000845 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 714313000846 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 714313000847 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 714313000848 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 714313000849 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 714313000850 active site 714313000851 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714313000852 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 714313000853 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313000854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313000855 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313000856 Probable transposase; Region: OrfB_IS605; pfam01385 714313000857 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313000858 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714313000859 Integrase core domain; Region: rve_3; pfam13683 714313000860 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 714313000861 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 714313000862 Cl- selectivity filter; other site 714313000863 Cl- binding residues [ion binding]; other site 714313000864 pore gating glutamate residue; other site 714313000865 dimer interface [polypeptide binding]; other site 714313000866 H+/Cl- coupling transport residue; other site 714313000867 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714313000868 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714313000869 Nucleoside recognition; Region: Gate; pfam07670 714313000870 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714313000871 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 714313000872 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 714313000873 active site 714313000874 tetramer interface [polypeptide binding]; other site 714313000875 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 714313000876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313000877 S-adenosylmethionine binding site [chemical binding]; other site 714313000878 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714313000879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714313000880 P-loop; other site 714313000881 Magnesium ion binding site [ion binding]; other site 714313000882 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714313000883 Magnesium ion binding site [ion binding]; other site 714313000884 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 714313000885 ParB-like nuclease domain; Region: ParB; smart00470 714313000886 KorB domain; Region: KorB; pfam08535 714313000887 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 714313000888 GTP-binding protein YchF; Reviewed; Region: PRK09601 714313000889 YchF GTPase; Region: YchF; cd01900 714313000890 G1 box; other site 714313000891 GTP/Mg2+ binding site [chemical binding]; other site 714313000892 Switch I region; other site 714313000893 G2 box; other site 714313000894 Switch II region; other site 714313000895 G3 box; other site 714313000896 G4 box; other site 714313000897 G5 box; other site 714313000898 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 714313000899 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 714313000900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714313000901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714313000902 active site 714313000903 phosphorylation site [posttranslational modification] 714313000904 intermolecular recognition site; other site 714313000905 dimerization interface [polypeptide binding]; other site 714313000906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714313000907 DNA binding site [nucleotide binding] 714313000908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714313000909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714313000910 dimer interface [polypeptide binding]; other site 714313000911 phosphorylation site [posttranslational modification] 714313000912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714313000913 ATP binding site [chemical binding]; other site 714313000914 Mg2+ binding site [ion binding]; other site 714313000915 G-X-G motif; other site 714313000916 AzlC protein; Region: AzlC; pfam03591 714313000917 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 714313000918 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714313000919 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000920 catalytic core [active] 714313000921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313000922 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714313000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000924 putative substrate translocation pore; other site 714313000925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313000926 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 714313000927 active site 714313000928 catalytic residues [active] 714313000929 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 714313000930 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 714313000931 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714313000932 Part of AAA domain; Region: AAA_19; pfam13245 714313000933 Family description; Region: UvrD_C_2; pfam13538 714313000934 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714313000935 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714313000936 active site 714313000937 HIGH motif; other site 714313000938 dimer interface [polypeptide binding]; other site 714313000939 KMSKS motif; other site 714313000940 exopolyphosphatase; Region: exo_poly_only; TIGR03706 714313000941 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 714313000942 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 714313000943 homodimer interface [polypeptide binding]; other site 714313000944 catalytic residues [active] 714313000945 NAD binding site [chemical binding]; other site 714313000946 substrate binding pocket [chemical binding]; other site 714313000947 flexible flap; other site 714313000948 NAD-dependent deacetylase; Provisional; Region: PRK00481 714313000949 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 714313000950 NAD+ binding site [chemical binding]; other site 714313000951 substrate binding site [chemical binding]; other site 714313000952 putative Zn binding site [ion binding]; other site 714313000953 Protein of unknown function DUF72; Region: DUF72; pfam01904 714313000954 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 714313000955 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714313000956 active site 714313000957 HIGH motif; other site 714313000958 KMSKS motif; other site 714313000959 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714313000960 tRNA binding surface [nucleotide binding]; other site 714313000961 anticodon binding site; other site 714313000962 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 714313000963 dimer interface [polypeptide binding]; other site 714313000964 putative tRNA-binding site [nucleotide binding]; other site 714313000965 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714313000966 active site 714313000967 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 714313000968 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 714313000969 putative active site [active] 714313000970 putative metal binding site [ion binding]; other site 714313000971 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 714313000972 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 714313000973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313000974 S-adenosylmethionine binding site [chemical binding]; other site 714313000975 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 714313000976 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714313000977 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 714313000978 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 714313000979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 714313000980 ABC-ATPase subunit interface; other site 714313000981 dimer interface [polypeptide binding]; other site 714313000982 putative PBP binding regions; other site 714313000983 pur operon repressor; Provisional; Region: PRK09213 714313000984 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 714313000985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313000986 active site 714313000987 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 714313000988 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 714313000989 Substrate binding site; other site 714313000990 Mg++ binding site; other site 714313000991 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 714313000992 active site 714313000993 substrate binding site [chemical binding]; other site 714313000994 CoA binding site [chemical binding]; other site 714313000995 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 714313000996 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 714313000997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313000998 active site 714313000999 sugar phosphate phosphatase; Provisional; Region: PRK10513 714313001000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313001001 active site 714313001002 motif I; other site 714313001003 motif II; other site 714313001004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313001005 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714313001006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714313001007 Zn2+ binding site [ion binding]; other site 714313001008 Mg2+ binding site [ion binding]; other site 714313001009 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 714313001010 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 714313001011 CTP synthetase; Validated; Region: pyrG; PRK05380 714313001012 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 714313001013 Catalytic site [active] 714313001014 active site 714313001015 UTP binding site [chemical binding]; other site 714313001016 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 714313001017 active site 714313001018 putative oxyanion hole; other site 714313001019 catalytic triad [active] 714313001020 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 714313001021 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714313001022 hinge; other site 714313001023 active site 714313001024 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 714313001025 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714313001026 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 714313001027 drug efflux system protein MdtG; Provisional; Region: PRK09874 714313001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313001029 putative substrate translocation pore; other site 714313001030 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 714313001031 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714313001032 active site 714313001033 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313001034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313001035 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313001036 Probable transposase; Region: OrfB_IS605; pfam01385 714313001037 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313001038 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 714313001039 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714313001040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714313001041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714313001042 helicase 45; Provisional; Region: PTZ00424 714313001043 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714313001044 ATP binding site [chemical binding]; other site 714313001045 Mg++ binding site [ion binding]; other site 714313001046 motif III; other site 714313001047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313001048 nucleotide binding region [chemical binding]; other site 714313001049 ATP-binding site [chemical binding]; other site 714313001050 alanine racemase; Reviewed; Region: alr; PRK00053 714313001051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 714313001052 active site 714313001053 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714313001054 dimer interface [polypeptide binding]; other site 714313001055 substrate binding site [chemical binding]; other site 714313001056 catalytic residues [active] 714313001057 PemK-like protein; Region: PemK; pfam02452 714313001058 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 714313001059 putative active site [active] 714313001060 catalytic residue [active] 714313001061 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 714313001062 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 714313001063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313001064 ATP binding site [chemical binding]; other site 714313001065 putative Mg++ binding site [ion binding]; other site 714313001066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313001067 nucleotide binding region [chemical binding]; other site 714313001068 ATP-binding site [chemical binding]; other site 714313001069 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 714313001070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313001071 RNA binding surface [nucleotide binding]; other site 714313001072 hypothetical protein; Provisional; Region: PRK08582 714313001073 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 714313001074 RNA binding site [nucleotide binding]; other site 714313001075 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 714313001076 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 714313001077 Ligand Binding Site [chemical binding]; other site 714313001078 TilS substrate C-terminal domain; Region: TilS_C; smart00977 714313001079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313001080 active site 714313001081 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 714313001082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313001083 Walker A motif; other site 714313001084 ATP binding site [chemical binding]; other site 714313001085 Walker B motif; other site 714313001086 arginine finger; other site 714313001087 Peptidase family M41; Region: Peptidase_M41; pfam01434 714313001088 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 714313001089 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 714313001090 dimerization interface [polypeptide binding]; other site 714313001091 domain crossover interface; other site 714313001092 redox-dependent activation switch; other site 714313001093 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 714313001094 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714313001095 FMN binding site [chemical binding]; other site 714313001096 active site 714313001097 catalytic residues [active] 714313001098 substrate binding site [chemical binding]; other site 714313001099 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 714313001100 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 714313001101 dimer interface [polypeptide binding]; other site 714313001102 putative anticodon binding site; other site 714313001103 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 714313001104 motif 1; other site 714313001105 active site 714313001106 motif 2; other site 714313001107 motif 3; other site 714313001108 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 714313001109 DNA binding residues [nucleotide binding] 714313001110 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 714313001111 putative dimer interface [polypeptide binding]; other site 714313001112 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 714313001113 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 714313001114 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 714313001115 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714313001116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313001117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313001118 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714313001119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714313001120 DNA-binding site [nucleotide binding]; DNA binding site 714313001121 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 714313001122 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 714313001123 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 714313001124 active site 714313001125 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 714313001126 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 714313001127 homodimer interface [polypeptide binding]; other site 714313001128 NAD binding pocket [chemical binding]; other site 714313001129 ATP binding pocket [chemical binding]; other site 714313001130 Mg binding site [ion binding]; other site 714313001131 active-site loop [active] 714313001132 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 714313001133 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 714313001134 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 714313001135 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 714313001136 RNA binding site [nucleotide binding]; other site 714313001137 hypothetical protein; Provisional; Region: PRK04351 714313001138 SprT homologues; Region: SprT; cl01182 714313001139 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714313001140 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313001141 catalytic core [active] 714313001142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313001143 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 714313001144 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 714313001145 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 714313001146 trimer interface [polypeptide binding]; other site 714313001147 active site 714313001148 G bulge; other site 714313001149 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 714313001150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313001151 active site 714313001152 dimer interface [polypeptide binding]; other site 714313001153 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 714313001154 trimer interface [polypeptide binding]; other site 714313001155 active site 714313001156 DNA repair protein RadA; Provisional; Region: PRK11823 714313001157 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 714313001158 Walker A motif/ATP binding site; other site 714313001159 ATP binding site [chemical binding]; other site 714313001160 Walker B motif; other site 714313001161 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 714313001162 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 714313001163 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714313001164 active site 714313001165 HIGH motif; other site 714313001166 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714313001167 active site 714313001168 KMSKS motif; other site 714313001169 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 714313001170 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714313001171 active site 714313001172 HIGH motif; other site 714313001173 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714313001174 KMSKS motif; other site 714313001175 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714313001176 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 714313001177 active site 714313001178 metal binding site [ion binding]; metal-binding site 714313001179 dimerization interface [polypeptide binding]; other site 714313001180 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 714313001181 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 714313001182 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714313001183 YacP-like NYN domain; Region: NYN_YacP; pfam05991 714313001184 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 714313001185 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 714313001186 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 714313001187 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 714313001188 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 714313001189 putative homodimer interface [polypeptide binding]; other site 714313001190 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 714313001191 heterodimer interface [polypeptide binding]; other site 714313001192 homodimer interface [polypeptide binding]; other site 714313001193 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 714313001194 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 714313001195 23S rRNA interface [nucleotide binding]; other site 714313001196 L7/L12 interface [polypeptide binding]; other site 714313001197 putative thiostrepton binding site; other site 714313001198 L25 interface [polypeptide binding]; other site 714313001199 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 714313001200 mRNA/rRNA interface [nucleotide binding]; other site 714313001201 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 714313001202 23S rRNA interface [nucleotide binding]; other site 714313001203 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 714313001204 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 714313001205 peripheral dimer interface [polypeptide binding]; other site 714313001206 core dimer interface [polypeptide binding]; other site 714313001207 L10 interface [polypeptide binding]; other site 714313001208 L11 interface [polypeptide binding]; other site 714313001209 putative EF-Tu interaction site [polypeptide binding]; other site 714313001210 putative EF-G interaction site [polypeptide binding]; other site 714313001211 Predicted integral membrane protein [Function unknown]; Region: COG0392 714313001212 Uncharacterized conserved protein [Function unknown]; Region: COG2898 714313001213 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 714313001214 S-methylmethionine transporter; Provisional; Region: PRK11387 714313001215 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 714313001216 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 714313001217 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 714313001218 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714313001219 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313001220 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 714313001221 NAD binding site [chemical binding]; other site 714313001222 dimer interface [polypeptide binding]; other site 714313001223 substrate binding site [chemical binding]; other site 714313001224 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 714313001225 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 714313001226 dimer interface [polypeptide binding]; other site 714313001227 putative radical transfer pathway; other site 714313001228 diiron center [ion binding]; other site 714313001229 tyrosyl radical; other site 714313001230 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 714313001231 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 714313001232 Class I ribonucleotide reductase; Region: RNR_I; cd01679 714313001233 active site 714313001234 dimer interface [polypeptide binding]; other site 714313001235 catalytic residues [active] 714313001236 effector binding site; other site 714313001237 R2 peptide binding site; other site 714313001238 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 714313001239 catalytic residues [active] 714313001240 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 714313001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313001242 S-adenosylmethionine binding site [chemical binding]; other site 714313001243 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 714313001244 nucleoside/Zn binding site; other site 714313001245 dimer interface [polypeptide binding]; other site 714313001246 catalytic motif [active] 714313001247 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 714313001248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313001249 Walker A motif; other site 714313001250 ATP binding site [chemical binding]; other site 714313001251 Walker B motif; other site 714313001252 arginine finger; other site 714313001253 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 714313001254 hypothetical protein; Validated; Region: PRK00153 714313001255 recombination protein RecR; Reviewed; Region: recR; PRK00076 714313001256 RecR protein; Region: RecR; pfam02132 714313001257 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 714313001258 putative active site [active] 714313001259 putative metal-binding site [ion binding]; other site 714313001260 tetramer interface [polypeptide binding]; other site 714313001261 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 714313001262 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 714313001263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714313001264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714313001265 Walker A/P-loop; other site 714313001266 ATP binding site [chemical binding]; other site 714313001267 Q-loop/lid; other site 714313001268 ABC transporter signature motif; other site 714313001269 Walker B; other site 714313001270 D-loop; other site 714313001271 H-loop/switch region; other site 714313001272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714313001273 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714313001274 FtsX-like permease family; Region: FtsX; pfam02687 714313001275 thymidylate kinase; Validated; Region: tmk; PRK00698 714313001276 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714313001277 TMP-binding site; other site 714313001278 ATP-binding site [chemical binding]; other site 714313001279 Protein of unknown function (DUF970); Region: DUF970; cl17525 714313001280 DNA polymerase III subunit delta'; Validated; Region: PRK08058 714313001281 DNA polymerase III subunit delta'; Validated; Region: PRK08485 714313001282 Protein of unknown function (DUF972); Region: DUF972; pfam06156 714313001283 Predicted methyltransferases [General function prediction only]; Region: COG0313 714313001284 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 714313001285 putative SAM binding site [chemical binding]; other site 714313001286 putative homodimer interface [polypeptide binding]; other site 714313001287 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 714313001288 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714313001289 active site 714313001290 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714313001291 active site 714313001292 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 714313001293 Glycoprotease family; Region: Peptidase_M22; pfam00814 714313001294 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 714313001295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313001296 Coenzyme A binding pocket [chemical binding]; other site 714313001297 UGMP family protein; Validated; Region: PRK09604 714313001298 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 714313001299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714313001300 dimerization interface [polypeptide binding]; other site 714313001301 putative DNA binding site [nucleotide binding]; other site 714313001302 putative Zn2+ binding site [ion binding]; other site 714313001303 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 714313001304 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714313001305 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313001306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313001307 ABC transporter; Region: ABC_tran_2; pfam12848 714313001308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313001309 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 714313001310 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 714313001311 CoA binding domain; Region: CoA_binding; pfam02629 714313001312 Repair protein; Region: Repair_PSII; pfam04536 714313001313 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 714313001314 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 714313001315 oligomerisation interface [polypeptide binding]; other site 714313001316 mobile loop; other site 714313001317 roof hairpin; other site 714313001318 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 714313001319 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 714313001320 ring oligomerisation interface [polypeptide binding]; other site 714313001321 ATP/Mg binding site [chemical binding]; other site 714313001322 stacking interactions; other site 714313001323 hinge regions; other site 714313001324 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714313001325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714313001326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714313001327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313001328 Walker A/P-loop; other site 714313001329 ATP binding site [chemical binding]; other site 714313001330 Q-loop/lid; other site 714313001331 ABC transporter signature motif; other site 714313001332 Walker B; other site 714313001333 D-loop; other site 714313001334 H-loop/switch region; other site 714313001335 Uncharacterized conserved protein [Function unknown]; Region: COG1739 714313001336 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 714313001337 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 714313001338 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 714313001339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313001340 active site 714313001341 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 714313001342 30S subunit binding site; other site 714313001343 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 714313001344 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 714313001345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313001346 nucleotide binding region [chemical binding]; other site 714313001347 ATP-binding site [chemical binding]; other site 714313001348 peptide chain release factor 2; Validated; Region: prfB; PRK00578 714313001349 This domain is found in peptide chain release factors; Region: PCRF; smart00937 714313001350 RF-1 domain; Region: RF-1; pfam00472 714313001351 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714313001352 Membrane protein of unknown function; Region: DUF360; cl00850 714313001353 HPr kinase/phosphorylase; Provisional; Region: PRK05428 714313001354 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 714313001355 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 714313001356 Hpr binding site; other site 714313001357 active site 714313001358 homohexamer subunit interaction site [polypeptide binding]; other site 714313001359 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 714313001360 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 714313001361 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714313001362 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 714313001363 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714313001364 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714313001365 active site 714313001366 tetramer interface; other site 714313001367 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 714313001368 dimer interface [polypeptide binding]; other site 714313001369 catalytic triad [active] 714313001370 peroxidatic and resolving cysteines [active] 714313001371 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 714313001372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714313001373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714313001374 excinuclease ABC subunit B; Provisional; Region: PRK05298 714313001375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313001376 ATP binding site [chemical binding]; other site 714313001377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313001378 nucleotide binding region [chemical binding]; other site 714313001379 ATP-binding site [chemical binding]; other site 714313001380 Ultra-violet resistance protein B; Region: UvrB; pfam12344 714313001381 UvrB/uvrC motif; Region: UVR; pfam02151 714313001382 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 714313001383 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714313001384 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714313001385 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 714313001386 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 714313001387 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 714313001388 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 714313001389 phosphate binding site [ion binding]; other site 714313001390 putative substrate binding pocket [chemical binding]; other site 714313001391 dimer interface [polypeptide binding]; other site 714313001392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 714313001393 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 714313001394 Clp protease; Region: CLP_protease; pfam00574 714313001395 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714313001396 oligomer interface [polypeptide binding]; other site 714313001397 active site residues [active] 714313001398 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 714313001399 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 714313001400 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714313001401 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 714313001402 Phosphoglycerate kinase; Region: PGK; pfam00162 714313001403 substrate binding site [chemical binding]; other site 714313001404 hinge regions; other site 714313001405 ADP binding site [chemical binding]; other site 714313001406 catalytic site [active] 714313001407 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 714313001408 triosephosphate isomerase; Provisional; Region: PRK14567 714313001409 substrate binding site [chemical binding]; other site 714313001410 dimer interface [polypeptide binding]; other site 714313001411 catalytic triad [active] 714313001412 enolase; Provisional; Region: eno; PRK00077 714313001413 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 714313001414 dimer interface [polypeptide binding]; other site 714313001415 metal binding site [ion binding]; metal-binding site 714313001416 substrate binding pocket [chemical binding]; other site 714313001417 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 714313001418 ribonuclease R; Region: RNase_R; TIGR02063 714313001419 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 714313001420 RNB domain; Region: RNB; pfam00773 714313001421 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 714313001422 RNA binding site [nucleotide binding]; other site 714313001423 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 714313001424 SmpB-tmRNA interface; other site 714313001425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313001426 Homeodomain-like domain; Region: HTH_23; cl17451 714313001427 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313001428 HTH-like domain; Region: HTH_21; pfam13276 714313001429 Integrase core domain; Region: rve; pfam00665 714313001430 Integrase core domain; Region: rve_2; pfam13333 714313001431 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 714313001432 ligand binding site [chemical binding]; other site 714313001433 active site 714313001434 UGI interface [polypeptide binding]; other site 714313001435 catalytic site [active] 714313001436 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 714313001437 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 714313001438 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 714313001439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313001440 Coenzyme A binding pocket [chemical binding]; other site 714313001441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 714313001442 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 714313001443 active site 714313001444 catalytic site [active] 714313001445 substrate binding site [chemical binding]; other site 714313001446 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 714313001447 active site 714313001448 putative catalytic site [active] 714313001449 DNA binding site [nucleotide binding] 714313001450 putative phosphate binding site [ion binding]; other site 714313001451 metal binding site A [ion binding]; metal-binding site 714313001452 AP binding site [nucleotide binding]; other site 714313001453 metal binding site B [ion binding]; metal-binding site 714313001454 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 714313001455 FAD binding domain; Region: FAD_binding_4; pfam01565 714313001456 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714313001457 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 714313001458 Uncharacterized conserved protein [Function unknown]; Region: COG1624 714313001459 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714313001460 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 714313001461 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 714313001462 active site 714313001463 substrate binding site [chemical binding]; other site 714313001464 metal binding site [ion binding]; metal-binding site 714313001465 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 714313001466 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 714313001467 glutaminase active site [active] 714313001468 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 714313001469 dimer interface [polypeptide binding]; other site 714313001470 active site 714313001471 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 714313001472 dimer interface [polypeptide binding]; other site 714313001473 active site 714313001474 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 714313001475 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 714313001476 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 714313001477 putative dimer interface [polypeptide binding]; other site 714313001478 putative anticodon binding site; other site 714313001479 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714313001480 homodimer interface [polypeptide binding]; other site 714313001481 motif 1; other site 714313001482 motif 2; other site 714313001483 active site 714313001484 motif 3; other site 714313001485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313001486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313001487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313001488 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 714313001489 active site 714313001490 catalytic site [active] 714313001491 hypothetical protein; Provisional; Region: PRK04435 714313001492 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714313001493 Protein of unknown function (DUF805); Region: DUF805; pfam05656 714313001494 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 714313001495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714313001496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714313001497 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714313001498 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714313001499 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714313001500 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714313001501 active site 714313001502 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 714313001503 Predicted membrane protein [Function unknown]; Region: COG4684 714313001504 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 714313001505 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313001506 Walker A/P-loop; other site 714313001507 ATP binding site [chemical binding]; other site 714313001508 Q-loop/lid; other site 714313001509 ABC transporter signature motif; other site 714313001510 Walker B; other site 714313001511 D-loop; other site 714313001512 H-loop/switch region; other site 714313001513 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 714313001514 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313001515 Walker A/P-loop; other site 714313001516 ATP binding site [chemical binding]; other site 714313001517 Q-loop/lid; other site 714313001518 ABC transporter signature motif; other site 714313001519 Walker B; other site 714313001520 D-loop; other site 714313001521 H-loop/switch region; other site 714313001522 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714313001523 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 714313001524 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 714313001525 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 714313001526 Potassium binding sites [ion binding]; other site 714313001527 Cesium cation binding sites [ion binding]; other site 714313001528 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 714313001529 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 714313001530 tetramer interface [polypeptide binding]; other site 714313001531 active site 714313001532 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 714313001533 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 714313001534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313001535 active site 714313001536 motif I; other site 714313001537 motif II; other site 714313001538 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714313001539 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 714313001540 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 714313001541 putative RNA binding site [nucleotide binding]; other site 714313001542 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714313001543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714313001544 nucleotide binding site [chemical binding]; other site 714313001545 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 714313001546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 714313001547 active site 714313001548 dimer interface [polypeptide binding]; other site 714313001549 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 714313001550 dimer interface [polypeptide binding]; other site 714313001551 active site 714313001552 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 714313001553 active site 714313001554 catalytic site [active] 714313001555 recombination factor protein RarA; Reviewed; Region: PRK13342 714313001556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313001557 Walker A motif; other site 714313001558 ATP binding site [chemical binding]; other site 714313001559 Walker B motif; other site 714313001560 arginine finger; other site 714313001561 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 714313001562 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 714313001563 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 714313001564 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 714313001565 active site 714313001566 FMN binding site [chemical binding]; other site 714313001567 substrate binding site [chemical binding]; other site 714313001568 catalytic residues [active] 714313001569 homodimer interface [polypeptide binding]; other site 714313001570 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 714313001571 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714313001572 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714313001573 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 714313001574 Predicted membrane protein [Function unknown]; Region: COG4325 714313001575 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 714313001576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714313001577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714313001578 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714313001579 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 714313001580 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 714313001581 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714313001582 active site 714313001583 HIGH motif; other site 714313001584 KMSK motif region; other site 714313001585 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 714313001586 tRNA binding surface [nucleotide binding]; other site 714313001587 anticodon binding site; other site 714313001588 Transglycosylase; Region: Transgly; pfam00912 714313001589 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714313001590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 714313001591 Protein of unknown function (DUF964); Region: DUF964; cl01483 714313001592 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 714313001593 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714313001594 active site 714313001595 metal binding site [ion binding]; metal-binding site 714313001596 DNA binding site [nucleotide binding] 714313001597 AAA domain; Region: AAA_23; pfam13476 714313001598 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 714313001599 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714313001600 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 714313001601 HIT family signature motif; other site 714313001602 catalytic residue [active] 714313001603 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714313001604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714313001605 Walker A/P-loop; other site 714313001606 ATP binding site [chemical binding]; other site 714313001607 Q-loop/lid; other site 714313001608 ABC transporter signature motif; other site 714313001609 Walker B; other site 714313001610 D-loop; other site 714313001611 H-loop/switch region; other site 714313001612 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 714313001613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313001614 S-adenosylmethionine binding site [chemical binding]; other site 714313001615 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714313001616 catalytic residues [active] 714313001617 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714313001618 putative tRNA-binding site [nucleotide binding]; other site 714313001619 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 714313001620 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714313001621 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714313001622 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714313001623 DNA polymerase I; Provisional; Region: PRK05755 714313001624 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714313001625 active site 714313001626 metal binding site 1 [ion binding]; metal-binding site 714313001627 putative 5' ssDNA interaction site; other site 714313001628 metal binding site 3; metal-binding site 714313001629 metal binding site 2 [ion binding]; metal-binding site 714313001630 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714313001631 putative DNA binding site [nucleotide binding]; other site 714313001632 putative metal binding site [ion binding]; other site 714313001633 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 714313001634 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 714313001635 active site 714313001636 DNA binding site [nucleotide binding] 714313001637 catalytic site [active] 714313001638 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 714313001639 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 714313001640 DNA binding site [nucleotide binding] 714313001641 catalytic residue [active] 714313001642 H2TH interface [polypeptide binding]; other site 714313001643 putative catalytic residues [active] 714313001644 turnover-facilitating residue; other site 714313001645 intercalation triad [nucleotide binding]; other site 714313001646 8OG recognition residue [nucleotide binding]; other site 714313001647 putative reading head residues; other site 714313001648 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 714313001649 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714313001650 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 714313001651 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 714313001652 CoA-binding site [chemical binding]; other site 714313001653 ATP-binding [chemical binding]; other site 714313001654 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 714313001655 ATP cone domain; Region: ATP-cone; pfam03477 714313001656 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 714313001657 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714313001658 primosomal protein DnaI; Reviewed; Region: PRK08939 714313001659 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 714313001660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 714313001661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313001662 Walker A motif; other site 714313001663 ATP binding site [chemical binding]; other site 714313001664 Walker B motif; other site 714313001665 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714313001666 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 714313001667 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714313001668 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714313001669 active site 714313001670 dimer interface [polypeptide binding]; other site 714313001671 motif 1; other site 714313001672 motif 2; other site 714313001673 motif 3; other site 714313001674 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714313001675 anticodon binding site; other site 714313001676 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 714313001677 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 714313001678 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 714313001679 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 714313001680 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 714313001681 23S rRNA binding site [nucleotide binding]; other site 714313001682 L21 binding site [polypeptide binding]; other site 714313001683 L13 binding site [polypeptide binding]; other site 714313001684 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 714313001685 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 714313001686 GTPase YqeH; Provisional; Region: PRK13796 714313001687 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 714313001688 GTP/Mg2+ binding site [chemical binding]; other site 714313001689 G4 box; other site 714313001690 G5 box; other site 714313001691 G1 box; other site 714313001692 Switch I region; other site 714313001693 G2 box; other site 714313001694 G3 box; other site 714313001695 Switch II region; other site 714313001696 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 714313001697 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 714313001698 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 714313001699 active site 714313001700 (T/H)XGH motif; other site 714313001701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714313001702 Zn2+ binding site [ion binding]; other site 714313001703 Mg2+ binding site [ion binding]; other site 714313001704 Oligomerisation domain; Region: Oligomerisation; pfam02410 714313001705 Methyltransferase domain; Region: Methyltransf_23; pfam13489 714313001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313001707 S-adenosylmethionine binding site [chemical binding]; other site 714313001708 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 714313001709 hypothetical protein; Provisional; Region: PRK13670 714313001710 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 714313001711 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 714313001712 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 714313001713 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 714313001714 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714313001715 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 714313001716 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 714313001717 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714313001718 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 714313001719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 714313001720 Predicted transcriptional regulators [Transcription]; Region: COG1733 714313001721 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714313001722 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 714313001723 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 714313001724 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 714313001725 dimer interface [polypeptide binding]; other site 714313001726 motif 1; other site 714313001727 active site 714313001728 motif 2; other site 714313001729 motif 3; other site 714313001730 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 714313001731 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714313001732 putative tRNA-binding site [nucleotide binding]; other site 714313001733 B3/4 domain; Region: B3_4; pfam03483 714313001734 tRNA synthetase B5 domain; Region: B5; smart00874 714313001735 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 714313001736 dimer interface [polypeptide binding]; other site 714313001737 motif 1; other site 714313001738 motif 3; other site 714313001739 motif 2; other site 714313001740 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 714313001741 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 714313001742 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 714313001743 Sugar specificity; other site 714313001744 Pyrimidine base specificity; other site 714313001745 ATP-binding site [chemical binding]; other site 714313001746 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 714313001747 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 714313001748 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714313001749 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714313001750 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714313001751 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714313001752 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714313001753 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 714313001754 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 714313001755 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 714313001756 Rhomboid family; Region: Rhomboid; pfam01694 714313001757 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 714313001758 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 714313001759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714313001760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 714313001761 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714313001762 active site residue [active] 714313001763 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 714313001764 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 714313001765 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 714313001766 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 714313001767 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 714313001768 Protein of unknown function (DUF464); Region: DUF464; pfam04327 714313001769 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 714313001770 elongation factor P; Validated; Region: PRK00529 714313001771 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 714313001772 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 714313001773 RNA binding site [nucleotide binding]; other site 714313001774 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 714313001775 RNA binding site [nucleotide binding]; other site 714313001776 Asp23 family; Region: Asp23; pfam03780 714313001777 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 714313001778 putative RNA binding site [nucleotide binding]; other site 714313001779 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 714313001780 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 714313001781 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 714313001782 homodimer interface [polypeptide binding]; other site 714313001783 NADP binding site [chemical binding]; other site 714313001784 substrate binding site [chemical binding]; other site 714313001785 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 714313001786 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 714313001787 generic binding surface II; other site 714313001788 generic binding surface I; other site 714313001789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714313001790 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 714313001791 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714313001792 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714313001793 substrate binding pocket [chemical binding]; other site 714313001794 chain length determination region; other site 714313001795 substrate-Mg2+ binding site; other site 714313001796 catalytic residues [active] 714313001797 aspartate-rich region 1; other site 714313001798 active site lid residues [active] 714313001799 aspartate-rich region 2; other site 714313001800 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 714313001801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313001802 RNA binding surface [nucleotide binding]; other site 714313001803 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 714313001804 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 714313001805 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 714313001806 Walker A/P-loop; other site 714313001807 ATP binding site [chemical binding]; other site 714313001808 Q-loop/lid; other site 714313001809 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714313001810 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 714313001811 ABC transporter signature motif; other site 714313001812 Walker B; other site 714313001813 D-loop; other site 714313001814 H-loop/switch region; other site 714313001815 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 714313001816 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 714313001817 catalytic site [active] 714313001818 G-X2-G-X-G-K; other site 714313001819 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 714313001820 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 714313001821 Flavoprotein; Region: Flavoprotein; pfam02441 714313001822 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 714313001823 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 714313001824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313001825 ATP binding site [chemical binding]; other site 714313001826 putative Mg++ binding site [ion binding]; other site 714313001827 helicase superfamily c-terminal domain; Region: HELICc; smart00490 714313001828 nucleotide binding region [chemical binding]; other site 714313001829 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 714313001830 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 714313001831 putative active site [active] 714313001832 substrate binding site [chemical binding]; other site 714313001833 putative cosubstrate binding site; other site 714313001834 catalytic site [active] 714313001835 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 714313001836 substrate binding site [chemical binding]; other site 714313001837 16S rRNA methyltransferase B; Provisional; Region: PRK14902 714313001838 NusB family; Region: NusB; pfam01029 714313001839 putative RNA binding site [nucleotide binding]; other site 714313001840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313001841 S-adenosylmethionine binding site [chemical binding]; other site 714313001842 GTPase RsgA; Reviewed; Region: PRK00098 714313001843 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 714313001844 RNA binding site [nucleotide binding]; other site 714313001845 homodimer interface [polypeptide binding]; other site 714313001846 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 714313001847 GTPase/Zn-binding domain interface [polypeptide binding]; other site 714313001848 GTP/Mg2+ binding site [chemical binding]; other site 714313001849 G4 box; other site 714313001850 G5 box; other site 714313001851 G1 box; other site 714313001852 Switch I region; other site 714313001853 G2 box; other site 714313001854 G3 box; other site 714313001855 Switch II region; other site 714313001856 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 714313001857 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 714313001858 substrate binding site [chemical binding]; other site 714313001859 hexamer interface [polypeptide binding]; other site 714313001860 metal binding site [ion binding]; metal-binding site 714313001861 Thiamine pyrophosphokinase; Region: TPK; cd07995 714313001862 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 714313001863 active site 714313001864 dimerization interface [polypeptide binding]; other site 714313001865 thiamine binding site [chemical binding]; other site 714313001866 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 714313001867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 714313001868 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 714313001869 DAK2 domain; Region: Dak2; pfam02734 714313001870 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 714313001871 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 714313001872 generic binding surface II; other site 714313001873 ssDNA binding site; other site 714313001874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313001875 ATP binding site [chemical binding]; other site 714313001876 putative Mg++ binding site [ion binding]; other site 714313001877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313001878 nucleotide binding region [chemical binding]; other site 714313001879 ATP-binding site [chemical binding]; other site 714313001880 putative phosphate acyltransferase; Provisional; Region: PRK05331 714313001881 ribonuclease III; Reviewed; Region: rnc; PRK00102 714313001882 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 714313001883 dimerization interface [polypeptide binding]; other site 714313001884 active site 714313001885 metal binding site [ion binding]; metal-binding site 714313001886 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 714313001887 dsRNA binding site [nucleotide binding]; other site 714313001888 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 714313001889 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 714313001890 Walker A/P-loop; other site 714313001891 ATP binding site [chemical binding]; other site 714313001892 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 714313001893 variable surface protein Vir23; Provisional; Region: PTZ00250 714313001894 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 714313001895 ABC transporter signature motif; other site 714313001896 Walker B; other site 714313001897 D-loop; other site 714313001898 H-loop/switch region; other site 714313001899 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 714313001900 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 714313001901 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714313001902 P loop; other site 714313001903 GTP binding site [chemical binding]; other site 714313001904 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 714313001905 putative DNA-binding protein; Validated; Region: PRK00118 714313001906 signal recognition particle protein; Provisional; Region: PRK10867 714313001907 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 714313001908 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714313001909 P loop; other site 714313001910 GTP binding site [chemical binding]; other site 714313001911 Signal peptide binding domain; Region: SRP_SPB; pfam02978 714313001912 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 714313001913 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 714313001914 KH domain; Region: KH_4; pfam13083 714313001915 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 714313001916 RimM N-terminal domain; Region: RimM; pfam01782 714313001917 PRC-barrel domain; Region: PRC; pfam05239 714313001918 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 714313001919 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 714313001920 inner membrane transporter YjeM; Provisional; Region: PRK15238 714313001921 Peptidase family C69; Region: Peptidase_C69; pfam03577 714313001922 glycerol kinase; Provisional; Region: glpK; PRK00047 714313001923 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 714313001924 N- and C-terminal domain interface [polypeptide binding]; other site 714313001925 active site 714313001926 MgATP binding site [chemical binding]; other site 714313001927 catalytic site [active] 714313001928 metal binding site [ion binding]; metal-binding site 714313001929 glycerol binding site [chemical binding]; other site 714313001930 homotetramer interface [polypeptide binding]; other site 714313001931 homodimer interface [polypeptide binding]; other site 714313001932 FBP binding site [chemical binding]; other site 714313001933 protein IIAGlc interface [polypeptide binding]; other site 714313001934 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714313001935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313001936 S-adenosylmethionine binding site [chemical binding]; other site 714313001937 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 714313001938 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 714313001939 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 714313001940 homotetramer interface [polypeptide binding]; other site 714313001941 FMN binding site [chemical binding]; other site 714313001942 homodimer contacts [polypeptide binding]; other site 714313001943 putative active site [active] 714313001944 putative substrate binding site [chemical binding]; other site 714313001945 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 714313001946 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714313001947 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 714313001948 diphosphomevalonate decarboxylase; Region: PLN02407 714313001949 mevalonate kinase; Region: mevalon_kin; TIGR00549 714313001950 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714313001951 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714313001952 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 714313001953 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714313001954 active site 714313001955 catalytic site [active] 714313001956 substrate binding site [chemical binding]; other site 714313001957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313001958 ATP binding site [chemical binding]; other site 714313001959 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714313001960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 714313001961 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 714313001962 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 714313001963 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 714313001964 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714313001965 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714313001966 substrate binding pocket [chemical binding]; other site 714313001967 chain length determination region; other site 714313001968 substrate-Mg2+ binding site; other site 714313001969 catalytic residues [active] 714313001970 aspartate-rich region 1; other site 714313001971 active site lid residues [active] 714313001972 aspartate-rich region 2; other site 714313001973 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 714313001974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714313001975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313001976 Walker A/P-loop; other site 714313001977 ATP binding site [chemical binding]; other site 714313001978 Q-loop/lid; other site 714313001979 ABC transporter signature motif; other site 714313001980 Walker B; other site 714313001981 D-loop; other site 714313001982 H-loop/switch region; other site 714313001983 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 714313001984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714313001985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313001986 Walker A/P-loop; other site 714313001987 ATP binding site [chemical binding]; other site 714313001988 Q-loop/lid; other site 714313001989 ABC transporter signature motif; other site 714313001990 Walker B; other site 714313001991 D-loop; other site 714313001992 H-loop/switch region; other site 714313001993 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 714313001994 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714313001995 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 714313001996 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714313001997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714313001998 Winged helix-turn helix; Region: HTH_29; pfam13551 714313001999 HTH-like domain; Region: HTH_21; pfam13276 714313002000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 714313002001 Integrase core domain; Region: rve; pfam00665 714313002002 Integrase core domain; Region: rve_3; cl15866 714313002003 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 714313002004 UbiA prenyltransferase family; Region: UbiA; pfam01040 714313002005 Transglycosylase; Region: Transgly; pfam00912 714313002006 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714313002007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 714313002008 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 714313002009 hypothetical protein; Provisional; Region: PRK13660 714313002010 cell division protein GpsB; Provisional; Region: PRK14127 714313002011 DivIVA domain; Region: DivI1A_domain; TIGR03544 714313002012 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 714313002013 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 714313002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714313002015 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714313002016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714313002017 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 714313002018 RNA/DNA hybrid binding site [nucleotide binding]; other site 714313002019 active site 714313002020 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 714313002021 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714313002022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313002023 RNA binding surface [nucleotide binding]; other site 714313002024 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714313002025 active site 714313002026 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 714313002027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313002028 active site 714313002029 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 714313002030 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 714313002031 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714313002032 conserved cys residue [active] 714313002033 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 714313002034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714313002035 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 714313002036 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 714313002037 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 714313002038 Domain of unknown function (DUF814); Region: DUF814; pfam05670 714313002039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714313002040 MarR family; Region: MarR_2; pfam12802 714313002041 EDD domain protein, DegV family; Region: DegV; TIGR00762 714313002042 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 714313002043 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714313002044 methionine sulfoxide reductase A; Provisional; Region: PRK14054 714313002045 methionine sulfoxide reductase B; Provisional; Region: PRK00222 714313002046 SelR domain; Region: SelR; pfam01641 714313002047 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 714313002048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 714313002049 DHHA2 domain; Region: DHHA2; pfam02833 714313002050 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 714313002051 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714313002052 CAP-like domain; other site 714313002053 active site 714313002054 primary dimer interface [polypeptide binding]; other site 714313002055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714313002056 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 714313002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714313002058 Mg2+ binding site [ion binding]; other site 714313002059 G-X-G motif; other site 714313002060 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714313002061 anchoring element; other site 714313002062 dimer interface [polypeptide binding]; other site 714313002063 ATP binding site [chemical binding]; other site 714313002064 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714313002065 active site 714313002066 putative metal-binding site [ion binding]; other site 714313002067 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714313002068 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 714313002069 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 714313002070 active site 714313002071 catalytic residues [active] 714313002072 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714313002073 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 714313002074 active site 714313002075 DNA binding site [nucleotide binding] 714313002076 Int/Topo IB signature motif; other site 714313002077 DNA topoisomerase I; Validated; Region: PRK05582 714313002078 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 714313002079 active site 714313002080 interdomain interaction site; other site 714313002081 putative metal-binding site [ion binding]; other site 714313002082 nucleotide binding site [chemical binding]; other site 714313002083 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714313002084 domain I; other site 714313002085 DNA binding groove [nucleotide binding] 714313002086 phosphate binding site [ion binding]; other site 714313002087 domain II; other site 714313002088 domain III; other site 714313002089 nucleotide binding site [chemical binding]; other site 714313002090 catalytic site [active] 714313002091 domain IV; other site 714313002092 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714313002093 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714313002094 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 714313002095 RNA/DNA hybrid binding site [nucleotide binding]; other site 714313002096 active site 714313002097 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 714313002098 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 714313002099 GTP/Mg2+ binding site [chemical binding]; other site 714313002100 G4 box; other site 714313002101 G5 box; other site 714313002102 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714313002103 G1 box; other site 714313002104 G1 box; other site 714313002105 GTP/Mg2+ binding site [chemical binding]; other site 714313002106 Switch I region; other site 714313002107 G2 box; other site 714313002108 G2 box; other site 714313002109 Switch I region; other site 714313002110 G3 box; other site 714313002111 G3 box; other site 714313002112 Switch II region; other site 714313002113 Switch II region; other site 714313002114 hypothetical protein; Provisional; Region: PRK13672 714313002115 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 714313002116 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 714313002117 folate binding site [chemical binding]; other site 714313002118 NADP+ binding site [chemical binding]; other site 714313002119 thymidylate synthase; Region: thym_sym; TIGR03284 714313002120 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 714313002121 dimerization interface [polypeptide binding]; other site 714313002122 active site 714313002123 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714313002124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313002125 Walker A/P-loop; other site 714313002126 ATP binding site [chemical binding]; other site 714313002127 Q-loop/lid; other site 714313002128 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313002129 ABC transporter signature motif; other site 714313002130 Walker B; other site 714313002131 D-loop; other site 714313002132 ABC transporter; Region: ABC_tran_2; pfam12848 714313002133 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714313002134 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 714313002135 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 714313002136 active site 714313002137 NTP binding site [chemical binding]; other site 714313002138 metal binding triad [ion binding]; metal-binding site 714313002139 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 714313002140 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 714313002141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002142 binding surface 714313002143 TPR motif; other site 714313002144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002145 TPR motif; other site 714313002146 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714313002147 binding surface 714313002148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714313002149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002150 binding surface 714313002151 TPR motif; other site 714313002152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002153 binding surface 714313002154 TPR motif; other site 714313002155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714313002156 IHF dimer interface [polypeptide binding]; other site 714313002157 IHF - DNA interface [nucleotide binding]; other site 714313002158 GTP-binding protein Der; Reviewed; Region: PRK00093 714313002159 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 714313002160 G1 box; other site 714313002161 GTP/Mg2+ binding site [chemical binding]; other site 714313002162 Switch I region; other site 714313002163 G2 box; other site 714313002164 Switch II region; other site 714313002165 G3 box; other site 714313002166 G4 box; other site 714313002167 G5 box; other site 714313002168 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 714313002169 G1 box; other site 714313002170 GTP/Mg2+ binding site [chemical binding]; other site 714313002171 Switch I region; other site 714313002172 G2 box; other site 714313002173 G3 box; other site 714313002174 Switch II region; other site 714313002175 G4 box; other site 714313002176 G5 box; other site 714313002177 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 714313002178 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 714313002179 RNA binding site [nucleotide binding]; other site 714313002180 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 714313002181 RNA binding site [nucleotide binding]; other site 714313002182 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 714313002183 RNA binding site [nucleotide binding]; other site 714313002184 cytidylate kinase; Provisional; Region: cmk; PRK00023 714313002185 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 714313002186 CMP-binding site; other site 714313002187 The sites determining sugar specificity; other site 714313002188 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714313002189 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 714313002190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714313002191 ATP binding site [chemical binding]; other site 714313002192 putative Mg++ binding site [ion binding]; other site 714313002193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313002194 nucleotide binding region [chemical binding]; other site 714313002195 ATP-binding site [chemical binding]; other site 714313002196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 714313002197 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714313002198 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313002199 RNA binding surface [nucleotide binding]; other site 714313002200 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 714313002201 active site 714313002202 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 714313002203 ScpA/B protein; Region: ScpA_ScpB; cl00598 714313002204 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714313002205 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 714313002206 active site 714313002207 Int/Topo IB signature motif; other site 714313002208 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 714313002209 S1 domain; Region: S1_2; pfam13509 714313002210 pyruvate kinase; Provisional; Region: PRK06354 714313002211 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 714313002212 domain interfaces; other site 714313002213 active site 714313002214 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 714313002215 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 714313002216 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 714313002217 active site 714313002218 PHP Thumb interface [polypeptide binding]; other site 714313002219 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 714313002220 generic binding surface I; other site 714313002221 generic binding surface II; other site 714313002222 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714313002223 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 714313002224 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 714313002225 Family of unknown function (DUF633); Region: DUF633; pfam04816 714313002226 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 714313002227 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 714313002228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714313002229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714313002230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714313002231 DNA binding residues [nucleotide binding] 714313002232 DNA primase; Validated; Region: dnaG; PRK05667 714313002233 CHC2 zinc finger; Region: zf-CHC2; pfam01807 714313002234 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 714313002235 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 714313002236 active site 714313002237 metal binding site [ion binding]; metal-binding site 714313002238 interdomain interaction site; other site 714313002239 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 714313002240 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 714313002241 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 714313002242 dimer interface [polypeptide binding]; other site 714313002243 motif 1; other site 714313002244 active site 714313002245 motif 2; other site 714313002246 motif 3; other site 714313002247 Recombination protein O N terminal; Region: RecO_N; pfam11967 714313002248 DNA repair protein RecO; Region: reco; TIGR00613 714313002249 Recombination protein O C terminal; Region: RecO_C; pfam02565 714313002250 GTPase Era; Reviewed; Region: era; PRK00089 714313002251 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 714313002252 G1 box; other site 714313002253 GTP/Mg2+ binding site [chemical binding]; other site 714313002254 Switch I region; other site 714313002255 G2 box; other site 714313002256 Switch II region; other site 714313002257 G3 box; other site 714313002258 G4 box; other site 714313002259 G5 box; other site 714313002260 KH domain; Region: KH_2; pfam07650 714313002261 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 714313002262 metal-binding heat shock protein; Provisional; Region: PRK00016 714313002263 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 714313002264 PhoH-like protein; Region: PhoH; pfam02562 714313002265 Yqey-like protein; Region: YqeY; pfam09424 714313002266 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 714313002267 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 714313002268 endonuclease IV; Provisional; Region: PRK01060 714313002269 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714313002270 AP (apurinic/apyrimidinic) site pocket; other site 714313002271 DNA interaction; other site 714313002272 Metal-binding active site; metal-binding site 714313002273 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 714313002274 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714313002275 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714313002276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714313002277 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 714313002278 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 714313002279 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 714313002280 dimer interface [polypeptide binding]; other site 714313002281 anticodon binding site; other site 714313002282 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 714313002283 homodimer interface [polypeptide binding]; other site 714313002284 motif 1; other site 714313002285 active site 714313002286 motif 2; other site 714313002287 GAD domain; Region: GAD; pfam02938 714313002288 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714313002289 active site 714313002290 motif 3; other site 714313002291 Bacterial SH3 domain; Region: SH3_3; pfam08239 714313002292 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714313002293 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714313002294 active site 714313002295 metal binding site [ion binding]; metal-binding site 714313002296 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714313002297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313002298 motif II; other site 714313002299 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 714313002300 putative active site [active] 714313002301 dimerization interface [polypeptide binding]; other site 714313002302 putative tRNAtyr binding site [nucleotide binding]; other site 714313002303 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 714313002304 HD domain; Region: HD_4; pfam13328 714313002305 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714313002306 synthetase active site [active] 714313002307 NTP binding site [chemical binding]; other site 714313002308 metal binding site [ion binding]; metal-binding site 714313002309 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 714313002310 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 714313002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 714313002312 RNA methyltransferase, RsmE family; Region: TIGR00046 714313002313 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 714313002314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313002315 S-adenosylmethionine binding site [chemical binding]; other site 714313002316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714313002317 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714313002318 active site 714313002319 metal binding site [ion binding]; metal-binding site 714313002320 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714313002321 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714313002322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714313002323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714313002324 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 714313002325 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714313002326 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 714313002327 GTP-binding protein LepA; Provisional; Region: PRK05433 714313002328 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 714313002329 G1 box; other site 714313002330 putative GEF interaction site [polypeptide binding]; other site 714313002331 GTP/Mg2+ binding site [chemical binding]; other site 714313002332 Switch I region; other site 714313002333 G2 box; other site 714313002334 G3 box; other site 714313002335 Switch II region; other site 714313002336 G4 box; other site 714313002337 G5 box; other site 714313002338 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 714313002339 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 714313002340 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 714313002341 chaperone protein DnaJ; Provisional; Region: PRK14276 714313002342 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714313002343 HSP70 interaction site [polypeptide binding]; other site 714313002344 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 714313002345 substrate binding site [polypeptide binding]; other site 714313002346 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714313002347 Zn binding sites [ion binding]; other site 714313002348 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 714313002349 dimer interface [polypeptide binding]; other site 714313002350 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 714313002351 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 714313002352 nucleotide binding site [chemical binding]; other site 714313002353 NEF interaction site [polypeptide binding]; other site 714313002354 SBD interface [polypeptide binding]; other site 714313002355 GrpE; Region: GrpE; pfam01025 714313002356 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 714313002357 dimer interface [polypeptide binding]; other site 714313002358 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 714313002359 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 714313002360 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 714313002361 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 714313002362 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 714313002363 active site 714313002364 Riboflavin kinase; Region: Flavokinase; smart00904 714313002365 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 714313002366 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 714313002367 RNA binding site [nucleotide binding]; other site 714313002368 active site 714313002369 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 714313002370 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714313002371 translation initiation factor IF-2; Region: IF-2; TIGR00487 714313002372 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714313002373 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 714313002374 G1 box; other site 714313002375 putative GEF interaction site [polypeptide binding]; other site 714313002376 GTP/Mg2+ binding site [chemical binding]; other site 714313002377 Switch I region; other site 714313002378 G2 box; other site 714313002379 G3 box; other site 714313002380 Switch II region; other site 714313002381 G4 box; other site 714313002382 G5 box; other site 714313002383 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 714313002384 Translation-initiation factor 2; Region: IF-2; pfam11987 714313002385 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 714313002386 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 714313002387 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 714313002388 putative RNA binding cleft [nucleotide binding]; other site 714313002389 Sm and related proteins; Region: Sm_like; cl00259 714313002390 ribosome maturation protein RimP; Reviewed; Region: PRK00092 714313002391 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 714313002392 putative oligomer interface [polypeptide binding]; other site 714313002393 putative RNA binding site [nucleotide binding]; other site 714313002394 DNA polymerase III PolC; Validated; Region: polC; PRK00448 714313002395 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 714313002396 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 714313002397 generic binding surface II; other site 714313002398 generic binding surface I; other site 714313002399 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 714313002400 active site 714313002401 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714313002402 active site 714313002403 catalytic site [active] 714313002404 substrate binding site [chemical binding]; other site 714313002405 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 714313002406 prolyl-tRNA synthetase; Provisional; Region: PRK09194 714313002407 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714313002408 motif 1; other site 714313002409 dimer interface [polypeptide binding]; other site 714313002410 active site 714313002411 motif 2; other site 714313002412 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 714313002413 putative deacylase active site [active] 714313002414 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714313002415 active site 714313002416 motif 3; other site 714313002417 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 714313002418 anticodon binding site; other site 714313002419 RIP metalloprotease RseP; Region: TIGR00054 714313002420 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714313002421 active site 714313002422 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 714313002423 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 714313002424 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714313002425 putative substrate binding region [chemical binding]; other site 714313002426 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 714313002427 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 714313002428 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 714313002429 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 714313002430 catalytic residue [active] 714313002431 putative FPP diphosphate binding site; other site 714313002432 putative FPP binding hydrophobic cleft; other site 714313002433 dimer interface [polypeptide binding]; other site 714313002434 putative IPP diphosphate binding site; other site 714313002435 ribosome recycling factor; Reviewed; Region: frr; PRK00083 714313002436 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 714313002437 hinge region; other site 714313002438 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714313002439 putative nucleotide binding site [chemical binding]; other site 714313002440 uridine monophosphate binding site [chemical binding]; other site 714313002441 homohexameric interface [polypeptide binding]; other site 714313002442 elongation factor Ts; Provisional; Region: tsf; PRK09377 714313002443 UBA/TS-N domain; Region: UBA; pfam00627 714313002444 Elongation factor TS; Region: EF_TS; pfam00889 714313002445 Elongation factor TS; Region: EF_TS; pfam00889 714313002446 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 714313002447 rRNA interaction site [nucleotide binding]; other site 714313002448 S8 interaction site; other site 714313002449 putative laminin-1 binding site; other site 714313002450 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 714313002451 GIY-YIG motif/motif A; other site 714313002452 putative active site [active] 714313002453 putative metal binding site [ion binding]; other site 714313002454 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 714313002455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313002456 S-adenosylmethionine binding site [chemical binding]; other site 714313002457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 714313002458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714313002459 putative acyl-acceptor binding pocket; other site 714313002460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 714313002461 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 714313002462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714313002463 putative DNA binding site [nucleotide binding]; other site 714313002464 LexA repressor; Validated; Region: PRK00215 714313002465 putative Zn2+ binding site [ion binding]; other site 714313002466 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714313002467 Catalytic site [active] 714313002468 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 714313002469 tetramer interfaces [polypeptide binding]; other site 714313002470 binuclear metal-binding site [ion binding]; other site 714313002471 CAAX protease self-immunity; Region: Abi; pfam02517 714313002472 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714313002473 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714313002474 Substrate-binding site [chemical binding]; other site 714313002475 Substrate specificity [chemical binding]; other site 714313002476 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 714313002477 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 714313002478 metal binding site [ion binding]; metal-binding site 714313002479 dimer interface [polypeptide binding]; other site 714313002480 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 714313002481 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 714313002482 dipeptidase PepV; Reviewed; Region: PRK07318 714313002483 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 714313002484 active site 714313002485 metal binding site [ion binding]; metal-binding site 714313002486 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 714313002487 putative substrate binding site [chemical binding]; other site 714313002488 putative ATP binding site [chemical binding]; other site 714313002489 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714313002490 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 714313002491 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 714313002492 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714313002493 HIGH motif; other site 714313002494 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714313002495 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714313002496 active site 714313002497 KMSKS motif; other site 714313002498 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 714313002499 tRNA binding surface [nucleotide binding]; other site 714313002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714313002501 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 714313002502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313002503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714313002504 putative substrate translocation pore; other site 714313002505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313002506 S-adenosylmethionine synthetase; Validated; Region: PRK05250 714313002507 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 714313002508 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 714313002509 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 714313002510 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714313002511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313002512 Walker A/P-loop; other site 714313002513 ATP binding site [chemical binding]; other site 714313002514 Q-loop/lid; other site 714313002515 ABC transporter signature motif; other site 714313002516 Walker B; other site 714313002517 D-loop; other site 714313002518 H-loop/switch region; other site 714313002519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313002520 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714313002521 dimer interface [polypeptide binding]; other site 714313002522 conserved gate region; other site 714313002523 putative PBP binding loops; other site 714313002524 ABC-ATPase subunit interface; other site 714313002525 uracil transporter; Provisional; Region: PRK10720 714313002526 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 714313002527 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 714313002528 dimer interface [polypeptide binding]; other site 714313002529 active site 714313002530 aromatic amino acid aminotransferase; Validated; Region: PRK07309 714313002531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714313002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714313002533 homodimer interface [polypeptide binding]; other site 714313002534 catalytic residue [active] 714313002535 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 714313002536 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 714313002537 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 714313002538 tetramer interface [polypeptide binding]; other site 714313002539 putative DNA binding site [nucleotide binding]; other site 714313002540 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 714313002541 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 714313002542 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 714313002543 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 714313002544 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714313002545 Beta-lactamase; Region: Beta-lactamase; pfam00144 714313002546 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 714313002547 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714313002548 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714313002549 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 714313002550 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 714313002551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313002552 active site 714313002553 motif I; other site 714313002554 motif II; other site 714313002555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714313002556 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 714313002557 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714313002558 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 714313002559 active site 714313002560 metal binding site [ion binding]; metal-binding site 714313002561 Phosphotransferase enzyme family; Region: APH; pfam01636 714313002562 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 714313002563 active site 714313002564 ATP binding site [chemical binding]; other site 714313002565 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714313002566 substrate binding site [chemical binding]; other site 714313002567 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714313002568 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 714313002569 propionate/acetate kinase; Provisional; Region: PRK12379 714313002570 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 714313002571 Methyltransferase domain; Region: Methyltransf_26; pfam13659 714313002572 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 714313002573 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 714313002574 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 714313002575 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714313002576 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714313002577 Type II/IV secretion system protein; Region: T2SE; pfam00437 714313002578 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 714313002579 Walker A motif; other site 714313002580 ATP binding site [chemical binding]; other site 714313002581 Walker B motif; other site 714313002582 hypothetical protein; Validated; Region: PRK00110 714313002583 catabolite control protein A; Region: ccpA; TIGR01481 714313002584 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714313002585 DNA binding site [nucleotide binding] 714313002586 domain linker motif; other site 714313002587 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 714313002588 dimerization interface [polypeptide binding]; other site 714313002589 effector binding site; other site 714313002590 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 714313002591 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 714313002592 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714313002593 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 714313002594 active site 714313002595 dimerization interface [polypeptide binding]; other site 714313002596 glutamate racemase; Provisional; Region: PRK00865 714313002597 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714313002598 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714313002599 catalytic residues [active] 714313002600 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 714313002601 MutS domain III; Region: MutS_III; pfam05192 714313002602 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 714313002603 Walker A/P-loop; other site 714313002604 ATP binding site [chemical binding]; other site 714313002605 Q-loop/lid; other site 714313002606 ABC transporter signature motif; other site 714313002607 Walker B; other site 714313002608 D-loop; other site 714313002609 H-loop/switch region; other site 714313002610 Smr domain; Region: Smr; pfam01713 714313002611 Colicin V production protein; Region: Colicin_V; pfam02674 714313002612 Cell division protein ZapA; Region: ZapA; pfam05164 714313002613 hypothetical protein; Provisional; Region: PRK13678 714313002614 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 714313002615 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 714313002616 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 714313002617 motif 1; other site 714313002618 active site 714313002619 motif 2; other site 714313002620 motif 3; other site 714313002621 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714313002622 DHHA1 domain; Region: DHHA1; pfam02272 714313002623 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714313002624 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714313002625 ATP binding site [chemical binding]; other site 714313002626 Mg++ binding site [ion binding]; other site 714313002627 motif III; other site 714313002628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313002629 nucleotide binding region [chemical binding]; other site 714313002630 ATP-binding site [chemical binding]; other site 714313002631 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 714313002632 DHH family; Region: DHH; pfam01368 714313002633 DHHA1 domain; Region: DHHA1; pfam02272 714313002634 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 714313002635 active site 714313002636 DNA polymerase IV; Validated; Region: PRK02406 714313002637 DNA binding site [nucleotide binding] 714313002638 Preprotein translocase subunit; Region: YajC; pfam02699 714313002639 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 714313002640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313002641 Walker A motif; other site 714313002642 ATP binding site [chemical binding]; other site 714313002643 Walker B motif; other site 714313002644 arginine finger; other site 714313002645 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 714313002646 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 714313002647 RuvA N terminal domain; Region: RuvA_N; pfam01330 714313002648 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 714313002649 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 714313002650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714313002651 ATP binding site [chemical binding]; other site 714313002652 Mg2+ binding site [ion binding]; other site 714313002653 G-X-G motif; other site 714313002654 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 714313002655 ATP binding site [chemical binding]; other site 714313002656 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 714313002657 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 714313002658 MutS domain I; Region: MutS_I; pfam01624 714313002659 MutS domain II; Region: MutS_II; pfam05188 714313002660 MutS domain III; Region: MutS_III; pfam05192 714313002661 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 714313002662 Walker A/P-loop; other site 714313002663 ATP binding site [chemical binding]; other site 714313002664 Q-loop/lid; other site 714313002665 ABC transporter signature motif; other site 714313002666 Walker B; other site 714313002667 D-loop; other site 714313002668 H-loop/switch region; other site 714313002669 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 714313002670 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714313002671 putative active site [active] 714313002672 metal binding site [ion binding]; metal-binding site 714313002673 homodimer binding site [polypeptide binding]; other site 714313002674 phosphodiesterase; Provisional; Region: PRK12704 714313002675 uncharacterized domain HDIG; Region: HDIG; TIGR00277 714313002676 competence damage-inducible protein A; Provisional; Region: PRK00549 714313002677 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 714313002678 putative MPT binding site; other site 714313002679 Competence-damaged protein; Region: CinA; pfam02464 714313002680 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 714313002681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714313002682 non-specific DNA binding site [nucleotide binding]; other site 714313002683 salt bridge; other site 714313002684 sequence-specific DNA binding site [nucleotide binding]; other site 714313002685 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714313002686 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714313002687 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714313002688 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714313002689 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 714313002690 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 714313002691 Switch I; other site 714313002692 Switch II; other site 714313002693 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 714313002694 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 714313002695 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 714313002696 rod shape-determining protein MreC; Provisional; Region: PRK13922 714313002697 rod shape-determining protein MreC; Region: MreC; pfam04085 714313002698 rod shape-determining protein MreB; Provisional; Region: PRK13927 714313002699 MreB and similar proteins; Region: MreB_like; cd10225 714313002700 nucleotide binding site [chemical binding]; other site 714313002701 Mg binding site [ion binding]; other site 714313002702 putative protofilament interaction site [polypeptide binding]; other site 714313002703 RodZ interaction site [polypeptide binding]; other site 714313002704 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 714313002705 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714313002706 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 714313002707 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714313002708 active site 714313002709 HIGH motif; other site 714313002710 nucleotide binding site [chemical binding]; other site 714313002711 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714313002712 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 714313002713 active site 714313002714 KMSKS motif; other site 714313002715 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 714313002716 tRNA binding surface [nucleotide binding]; other site 714313002717 anticodon binding site; other site 714313002718 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 714313002719 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 714313002720 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 714313002721 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 714313002722 Ligand Binding Site [chemical binding]; other site 714313002723 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 714313002724 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714313002725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714313002726 catalytic residue [active] 714313002727 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 714313002728 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 714313002729 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 714313002730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313002731 RNA binding surface [nucleotide binding]; other site 714313002732 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 714313002733 recombination factor protein RarA; Reviewed; Region: PRK13342 714313002734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313002735 Walker A motif; other site 714313002736 ATP binding site [chemical binding]; other site 714313002737 Walker B motif; other site 714313002738 arginine finger; other site 714313002739 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 714313002740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714313002741 Ligand Binding Site [chemical binding]; other site 714313002742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714313002743 non-specific DNA binding site [nucleotide binding]; other site 714313002744 salt bridge; other site 714313002745 sequence-specific DNA binding site [nucleotide binding]; other site 714313002746 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 714313002747 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714313002748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714313002749 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 714313002750 Uncharacterized conserved protein [Function unknown]; Region: COG0759 714313002751 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 714313002752 rod shape-determining protein MreB; Provisional; Region: PRK13930 714313002753 MreB and similar proteins; Region: MreB_like; cd10225 714313002754 nucleotide binding site [chemical binding]; other site 714313002755 Mg binding site [ion binding]; other site 714313002756 putative protofilament interaction site [polypeptide binding]; other site 714313002757 RodZ interaction site [polypeptide binding]; other site 714313002758 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 714313002759 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714313002760 hinge; other site 714313002761 active site 714313002762 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 714313002763 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 714313002764 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 714313002765 gamma subunit interface [polypeptide binding]; other site 714313002766 epsilon subunit interface [polypeptide binding]; other site 714313002767 LBP interface [polypeptide binding]; other site 714313002768 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 714313002769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714313002770 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 714313002771 alpha subunit interaction interface [polypeptide binding]; other site 714313002772 Walker A motif; other site 714313002773 ATP binding site [chemical binding]; other site 714313002774 Walker B motif; other site 714313002775 inhibitor binding site; inhibition site 714313002776 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714313002777 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 714313002778 core domain interface [polypeptide binding]; other site 714313002779 delta subunit interface [polypeptide binding]; other site 714313002780 epsilon subunit interface [polypeptide binding]; other site 714313002781 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 714313002782 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714313002783 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 714313002784 beta subunit interaction interface [polypeptide binding]; other site 714313002785 Walker A motif; other site 714313002786 ATP binding site [chemical binding]; other site 714313002787 Walker B motif; other site 714313002788 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714313002789 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 714313002790 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 714313002791 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 714313002792 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 714313002793 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 714313002794 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 714313002795 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 714313002796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313002797 active site 714313002798 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 714313002799 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 714313002800 dimer interface [polypeptide binding]; other site 714313002801 active site 714313002802 glycine-pyridoxal phosphate binding site [chemical binding]; other site 714313002803 folate binding site [chemical binding]; other site 714313002804 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 714313002805 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 714313002806 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 714313002807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313002808 S-adenosylmethionine binding site [chemical binding]; other site 714313002809 peptide chain release factor 1; Validated; Region: prfA; PRK00591 714313002810 This domain is found in peptide chain release factors; Region: PCRF; smart00937 714313002811 RF-1 domain; Region: RF-1; pfam00472 714313002812 thymidine kinase; Provisional; Region: PRK04296 714313002813 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 714313002814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714313002815 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 714313002816 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 714313002817 catalytic triad [active] 714313002818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313002819 active site 714313002820 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 714313002821 DHH family; Region: DHH; pfam01368 714313002822 DHHA1 domain; Region: DHHA1; pfam02272 714313002823 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 714313002824 ribonuclease Z; Region: RNase_Z; TIGR02651 714313002825 GTPase CgtA; Reviewed; Region: obgE; PRK12297 714313002826 GTP1/OBG; Region: GTP1_OBG; pfam01018 714313002827 Obg GTPase; Region: Obg; cd01898 714313002828 G1 box; other site 714313002829 GTP/Mg2+ binding site [chemical binding]; other site 714313002830 Switch I region; other site 714313002831 G2 box; other site 714313002832 G3 box; other site 714313002833 Switch II region; other site 714313002834 G4 box; other site 714313002835 G5 box; other site 714313002836 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 714313002837 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 714313002838 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714313002839 GIY-YIG motif/motif A; other site 714313002840 active site 714313002841 catalytic site [active] 714313002842 putative DNA binding site [nucleotide binding]; other site 714313002843 metal binding site [ion binding]; metal-binding site 714313002844 UvrB/uvrC motif; Region: UVR; pfam02151 714313002845 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 714313002846 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 714313002847 G1 box; other site 714313002848 GTP/Mg2+ binding site [chemical binding]; other site 714313002849 Switch I region; other site 714313002850 G2 box; other site 714313002851 G3 box; other site 714313002852 Switch II region; other site 714313002853 G4 box; other site 714313002854 G5 box; other site 714313002855 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 714313002856 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 714313002857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313002858 Walker A motif; other site 714313002859 ATP binding site [chemical binding]; other site 714313002860 Walker B motif; other site 714313002861 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714313002862 trigger factor; Provisional; Region: tig; PRK01490 714313002863 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714313002864 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 714313002865 elongation factor Tu; Reviewed; Region: PRK00049 714313002866 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 714313002867 G1 box; other site 714313002868 GEF interaction site [polypeptide binding]; other site 714313002869 GTP/Mg2+ binding site [chemical binding]; other site 714313002870 Switch I region; other site 714313002871 G2 box; other site 714313002872 G3 box; other site 714313002873 Switch II region; other site 714313002874 G4 box; other site 714313002875 G5 box; other site 714313002876 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 714313002877 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 714313002878 Antibiotic Binding Site [chemical binding]; other site 714313002879 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714313002880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714313002881 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714313002882 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 714313002883 16S/18S rRNA binding site [nucleotide binding]; other site 714313002884 S13e-L30e interaction site [polypeptide binding]; other site 714313002885 25S rRNA binding site [nucleotide binding]; other site 714313002886 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 714313002887 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714313002888 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714313002889 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 714313002890 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 714313002891 Competence protein; Region: Competence; pfam03772 714313002892 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 714313002893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714313002894 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 714313002895 catalytic motif [active] 714313002896 Zn binding site [ion binding]; other site 714313002897 SLBB domain; Region: SLBB; pfam10531 714313002898 comEA protein; Region: comE; TIGR01259 714313002899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313002900 Coenzyme A binding pocket [chemical binding]; other site 714313002901 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 714313002902 catalytic residues [active] 714313002903 dimer interface [polypeptide binding]; other site 714313002904 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 714313002905 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 714313002906 protein binding site [polypeptide binding]; other site 714313002907 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 714313002908 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 714313002909 active site 714313002910 (T/H)XGH motif; other site 714313002911 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 714313002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313002913 S-adenosylmethionine binding site [chemical binding]; other site 714313002914 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 714313002915 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 714313002916 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 714313002917 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 714313002918 G1 box; other site 714313002919 putative GEF interaction site [polypeptide binding]; other site 714313002920 GTP/Mg2+ binding site [chemical binding]; other site 714313002921 Switch I region; other site 714313002922 G2 box; other site 714313002923 G3 box; other site 714313002924 Switch II region; other site 714313002925 G4 box; other site 714313002926 G5 box; other site 714313002927 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 714313002928 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 714313002929 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 714313002930 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 714313002931 substrate binding site [chemical binding]; other site 714313002932 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714313002933 active site 714313002934 catalytic residues [active] 714313002935 metal binding site [ion binding]; metal-binding site 714313002936 hypothetical protein; Provisional; Region: PRK13667 714313002937 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714313002938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714313002939 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714313002940 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714313002941 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714313002942 active site 714313002943 catalytic tetrad [active] 714313002944 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 714313002945 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 714313002946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313002947 active site 714313002948 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 714313002949 AAA domain; Region: AAA_30; pfam13604 714313002950 Family description; Region: UvrD_C_2; pfam13538 714313002951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002952 binding surface 714313002953 TPR motif; other site 714313002954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714313002955 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 714313002956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714313002957 binding surface 714313002958 TPR motif; other site 714313002959 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313002960 catalytic core [active] 714313002961 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 714313002962 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 714313002963 Putative amino acid metabolism; Region: DUF1831; pfam08866 714313002964 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 714313002965 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714313002966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714313002967 catalytic residue [active] 714313002968 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 714313002969 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 714313002970 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714313002971 dimer interface [polypeptide binding]; other site 714313002972 ADP-ribose binding site [chemical binding]; other site 714313002973 active site 714313002974 nudix motif; other site 714313002975 metal binding site [ion binding]; metal-binding site 714313002976 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714313002977 DNA-binding site [nucleotide binding]; DNA binding site 714313002978 RNA-binding motif; other site 714313002979 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 714313002980 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714313002981 active site 714313002982 HIGH motif; other site 714313002983 nucleotide binding site [chemical binding]; other site 714313002984 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714313002985 active site 714313002986 KMSKS motif; other site 714313002987 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 714313002988 tRNA binding surface [nucleotide binding]; other site 714313002989 anticodon binding site; other site 714313002990 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714313002991 DivIVA protein; Region: DivIVA; pfam05103 714313002992 DivIVA domain; Region: DivI1A_domain; TIGR03544 714313002993 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 714313002994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714313002995 RNA binding surface [nucleotide binding]; other site 714313002996 YGGT family; Region: YGGT; pfam02325 714313002997 Protein of unknown function (DUF552); Region: DUF552; pfam04472 714313002998 cell division protein FtsZ; Validated; Region: PRK09330 714313002999 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 714313003000 nucleotide binding site [chemical binding]; other site 714313003001 SulA interaction site; other site 714313003002 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 714313003003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714313003004 nucleotide binding site [chemical binding]; other site 714313003005 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 714313003006 Cell division protein FtsA; Region: FtsA; pfam14450 714313003007 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 714313003008 Cell division protein FtsQ; Region: FtsQ; pfam03799 714313003009 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 714313003010 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714313003011 active site 714313003012 homodimer interface [polypeptide binding]; other site 714313003013 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 714313003014 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 714313003015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714313003016 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714313003017 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 714313003018 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 714313003019 Mg++ binding site [ion binding]; other site 714313003020 putative catalytic motif [active] 714313003021 putative substrate binding site [chemical binding]; other site 714313003022 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714313003023 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714313003024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714313003025 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 714313003026 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 714313003027 MraW methylase family; Region: Methyltransf_5; pfam01795 714313003028 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 714313003029 cell division protein MraZ; Reviewed; Region: PRK00326 714313003030 MraZ protein; Region: MraZ; pfam02381 714313003031 MraZ protein; Region: MraZ; pfam02381 714313003032 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 714313003033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313003034 putative substrate translocation pore; other site 714313003035 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 714313003036 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714313003037 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 714313003038 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 714313003039 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714313003040 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714313003041 active site 714313003042 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 714313003043 ATP-NAD kinase; Region: NAD_kinase; pfam01513 714313003044 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714313003045 synthetase active site [active] 714313003046 NTP binding site [chemical binding]; other site 714313003047 metal binding site [ion binding]; metal-binding site 714313003048 Thioredoxin; Region: Thioredoxin_5; pfam13743 714313003049 oligoendopeptidase F; Region: pepF; TIGR00181 714313003050 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 714313003051 active site 714313003052 Zn binding site [ion binding]; other site 714313003053 Competence protein CoiA-like family; Region: CoiA; cl11541 714313003054 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 714313003055 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 714313003056 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 714313003057 HTH-like domain; Region: HTH_21; pfam13276 714313003058 Integrase core domain; Region: rve; pfam00665 714313003059 Integrase core domain; Region: rve_2; pfam13333 714313003060 Homeodomain-like domain; Region: HTH_23; cl17451 714313003061 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003062 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714313003063 Sulfatase; Region: Sulfatase; pfam00884 714313003064 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 714313003065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714313003066 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714313003067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714313003068 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 714313003069 putative ADP-binding pocket [chemical binding]; other site 714313003070 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714313003071 dimerization domain swap beta strand [polypeptide binding]; other site 714313003072 regulatory protein interface [polypeptide binding]; other site 714313003073 active site 714313003074 regulatory phosphorylation site [posttranslational modification]; other site 714313003075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003076 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714313003077 Walker A motif; other site 714313003078 ATP binding site [chemical binding]; other site 714313003079 Walker B motif; other site 714313003080 arginine finger; other site 714313003081 UvrB/uvrC motif; Region: UVR; pfam02151 714313003082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003083 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714313003084 Walker A motif; other site 714313003085 ATP binding site [chemical binding]; other site 714313003086 Walker B motif; other site 714313003087 arginine finger; other site 714313003088 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 714313003089 HTH-like domain; Region: HTH_21; pfam13276 714313003090 Integrase core domain; Region: rve; pfam00665 714313003091 Integrase core domain; Region: rve_2; pfam13333 714313003092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003093 Homeodomain-like domain; Region: HTH_23; cl17451 714313003094 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003095 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 714313003096 argininosuccinate synthase; Provisional; Region: PRK13820 714313003097 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 714313003098 ANP binding site [chemical binding]; other site 714313003099 Substrate Binding Site II [chemical binding]; other site 714313003100 Substrate Binding Site I [chemical binding]; other site 714313003101 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714313003102 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714313003103 Walker A/P-loop; other site 714313003104 ATP binding site [chemical binding]; other site 714313003105 Q-loop/lid; other site 714313003106 ABC transporter signature motif; other site 714313003107 Walker B; other site 714313003108 D-loop; other site 714313003109 H-loop/switch region; other site 714313003110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714313003111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714313003112 substrate binding pocket [chemical binding]; other site 714313003113 membrane-bound complex binding site; other site 714313003114 hinge residues; other site 714313003115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313003116 dimer interface [polypeptide binding]; other site 714313003117 conserved gate region; other site 714313003118 ABC-ATPase subunit interface; other site 714313003119 BioY family; Region: BioY; pfam02632 714313003120 Peptidase family C69; Region: Peptidase_C69; pfam03577 714313003121 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 714313003122 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 714313003123 G1 box; other site 714313003124 putative GEF interaction site [polypeptide binding]; other site 714313003125 GTP/Mg2+ binding site [chemical binding]; other site 714313003126 Switch I region; other site 714313003127 G2 box; other site 714313003128 G3 box; other site 714313003129 Switch II region; other site 714313003130 G4 box; other site 714313003131 G5 box; other site 714313003132 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 714313003133 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714313003134 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714313003135 RecX family; Region: RecX; cl00936 714313003136 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 714313003137 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 714313003138 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 714313003139 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 714313003140 Ligand binding site; other site 714313003141 Putative Catalytic site; other site 714313003142 DXD motif; other site 714313003143 Predicted membrane protein [Function unknown]; Region: COG2246 714313003144 GtrA-like protein; Region: GtrA; pfam04138 714313003145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003146 Homeodomain-like domain; Region: HTH_23; cl17451 714313003147 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003148 HTH-like domain; Region: HTH_21; pfam13276 714313003149 Integrase core domain; Region: rve; pfam00665 714313003150 Integrase core domain; Region: rve_2; pfam13333 714313003151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 714313003152 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714313003153 ATP binding site [chemical binding]; other site 714313003154 putative Mg++ binding site [ion binding]; other site 714313003155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714313003156 nucleotide binding region [chemical binding]; other site 714313003157 ATP-binding site [chemical binding]; other site 714313003158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714313003159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714313003160 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 714313003161 active site 714313003162 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 714313003163 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 714313003164 N- and C-terminal domain interface [polypeptide binding]; other site 714313003165 active site 714313003166 catalytic site [active] 714313003167 metal binding site [ion binding]; metal-binding site 714313003168 carbohydrate binding site [chemical binding]; other site 714313003169 ATP binding site [chemical binding]; other site 714313003170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714313003171 non-specific DNA binding site [nucleotide binding]; other site 714313003172 salt bridge; other site 714313003173 sequence-specific DNA binding site [nucleotide binding]; other site 714313003174 hypothetical protein; Provisional; Region: PRK04435 714313003175 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 714313003176 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 714313003177 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 714313003178 metal binding site [ion binding]; metal-binding site 714313003179 dimer interface [polypeptide binding]; other site 714313003180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714313003181 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714313003182 Coenzyme A binding pocket [chemical binding]; other site 714313003183 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 714313003184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003185 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003187 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003188 putative transposase OrfB; Reviewed; Region: PHA02517 714313003189 HTH-like domain; Region: HTH_21; pfam13276 714313003190 Integrase core domain; Region: rve; pfam00665 714313003191 Integrase core domain; Region: rve_2; pfam13333 714313003192 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 714313003193 Integrase core domain; Region: rve; pfam00665 714313003194 Mrr N-terminal domain; Region: Mrr_N; pfam14338 714313003195 Restriction endonuclease; Region: Mrr_cat; pfam04471 714313003196 TRAM domain; Region: TRAM; pfam01938 714313003197 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 714313003198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714313003199 S-adenosylmethionine binding site [chemical binding]; other site 714313003200 putative lipid kinase; Reviewed; Region: PRK13055 714313003201 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 714313003202 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 714313003203 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 714313003204 GatB domain; Region: GatB_Yqey; smart00845 714313003205 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 714313003206 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 714313003207 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 714313003208 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 714313003209 putative dimer interface [polypeptide binding]; other site 714313003210 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 714313003211 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 714313003212 putative dimer interface [polypeptide binding]; other site 714313003213 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 714313003214 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 714313003215 nucleotide binding pocket [chemical binding]; other site 714313003216 K-X-D-G motif; other site 714313003217 catalytic site [active] 714313003218 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 714313003219 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 714313003220 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 714313003221 Dimer interface [polypeptide binding]; other site 714313003222 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 714313003223 Part of AAA domain; Region: AAA_19; pfam13245 714313003224 Family description; Region: UvrD_C_2; pfam13538 714313003225 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 714313003226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714313003227 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 714313003228 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 714313003229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714313003230 putative metal binding site [ion binding]; other site 714313003231 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714313003232 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 714313003233 D-lactate dehydrogenase; Provisional; Region: PRK11183 714313003234 FAD binding domain; Region: FAD_binding_4; pfam01565 714313003235 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 714313003236 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 714313003237 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 714313003238 23S rRNA interface [nucleotide binding]; other site 714313003239 L3 interface [polypeptide binding]; other site 714313003240 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 714313003241 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 714313003242 dimerization interface 3.5A [polypeptide binding]; other site 714313003243 active site 714313003244 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714313003245 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 714313003246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313003247 Walker A/P-loop; other site 714313003248 ATP binding site [chemical binding]; other site 714313003249 Q-loop/lid; other site 714313003250 ABC transporter signature motif; other site 714313003251 Walker B; other site 714313003252 D-loop; other site 714313003253 H-loop/switch region; other site 714313003254 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 714313003255 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714313003256 Walker A/P-loop; other site 714313003257 ATP binding site [chemical binding]; other site 714313003258 Q-loop/lid; other site 714313003259 ABC transporter signature motif; other site 714313003260 Walker B; other site 714313003261 D-loop; other site 714313003262 H-loop/switch region; other site 714313003263 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 714313003264 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 714313003265 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 714313003266 alphaNTD homodimer interface [polypeptide binding]; other site 714313003267 alphaNTD - beta interaction site [polypeptide binding]; other site 714313003268 alphaNTD - beta' interaction site [polypeptide binding]; other site 714313003269 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 714313003270 30S ribosomal protein S11; Validated; Region: PRK05309 714313003271 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 714313003272 30S ribosomal protein S13; Region: bact_S13; TIGR03631 714313003273 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 714313003274 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 714313003275 rRNA binding site [nucleotide binding]; other site 714313003276 predicted 30S ribosome binding site; other site 714313003277 adenylate kinase; Reviewed; Region: adk; PRK00279 714313003278 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 714313003279 AMP-binding site [chemical binding]; other site 714313003280 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 714313003281 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 714313003282 SecY translocase; Region: SecY; pfam00344 714313003283 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 714313003284 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 714313003285 23S rRNA binding site [nucleotide binding]; other site 714313003286 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 714313003287 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 714313003288 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 714313003289 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 714313003290 5S rRNA interface [nucleotide binding]; other site 714313003291 L27 interface [polypeptide binding]; other site 714313003292 23S rRNA interface [nucleotide binding]; other site 714313003293 L5 interface [polypeptide binding]; other site 714313003294 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 714313003295 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714313003296 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714313003297 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 714313003298 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 714313003299 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 714313003300 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 714313003301 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 714313003302 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 714313003303 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 714313003304 RNA binding site [nucleotide binding]; other site 714313003305 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 714313003306 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 714313003307 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 714313003308 23S rRNA interface [nucleotide binding]; other site 714313003309 putative translocon interaction site; other site 714313003310 signal recognition particle (SRP54) interaction site; other site 714313003311 L23 interface [polypeptide binding]; other site 714313003312 trigger factor interaction site; other site 714313003313 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 714313003314 23S rRNA interface [nucleotide binding]; other site 714313003315 5S rRNA interface [nucleotide binding]; other site 714313003316 putative antibiotic binding site [chemical binding]; other site 714313003317 L25 interface [polypeptide binding]; other site 714313003318 L27 interface [polypeptide binding]; other site 714313003319 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 714313003320 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 714313003321 G-X-X-G motif; other site 714313003322 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 714313003323 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 714313003324 putative translocon binding site; other site 714313003325 protein-rRNA interface [nucleotide binding]; other site 714313003326 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 714313003327 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 714313003328 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 714313003329 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 714313003330 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 714313003331 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 714313003332 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 714313003333 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 714313003334 elongation factor G; Reviewed; Region: PRK12739 714313003335 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 714313003336 G1 box; other site 714313003337 putative GEF interaction site [polypeptide binding]; other site 714313003338 GTP/Mg2+ binding site [chemical binding]; other site 714313003339 Switch I region; other site 714313003340 G2 box; other site 714313003341 G3 box; other site 714313003342 Switch II region; other site 714313003343 G4 box; other site 714313003344 G5 box; other site 714313003345 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 714313003346 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 714313003347 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 714313003348 30S ribosomal protein S7; Validated; Region: PRK05302 714313003349 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 714313003350 S17 interaction site [polypeptide binding]; other site 714313003351 S8 interaction site; other site 714313003352 16S rRNA interaction site [nucleotide binding]; other site 714313003353 streptomycin interaction site [chemical binding]; other site 714313003354 23S rRNA interaction site [nucleotide binding]; other site 714313003355 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 714313003356 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 714313003357 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 714313003358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313003359 active site 714313003360 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 714313003361 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 714313003362 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 714313003363 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 714313003364 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 714313003365 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 714313003366 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 714313003367 DNA binding site [nucleotide binding] 714313003368 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 714313003369 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 714313003370 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 714313003371 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 714313003372 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714313003373 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714313003374 RPB1 interaction site [polypeptide binding]; other site 714313003375 RPB11 interaction site [polypeptide binding]; other site 714313003376 RPB12 interaction site [polypeptide binding]; other site 714313003377 RPB10 interaction site [polypeptide binding]; other site 714313003378 RPB11 interaction site [polypeptide binding]; other site 714313003379 RPB3 interaction site [polypeptide binding]; other site 714313003380 RPB12 interaction site [polypeptide binding]; other site 714313003381 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 714313003382 Clp amino terminal domain; Region: Clp_N; pfam02861 714313003383 Clp amino terminal domain; Region: Clp_N; pfam02861 714313003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003385 Walker A motif; other site 714313003386 ATP binding site [chemical binding]; other site 714313003387 Walker B motif; other site 714313003388 arginine finger; other site 714313003389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003390 Walker A motif; other site 714313003391 ATP binding site [chemical binding]; other site 714313003392 Walker B motif; other site 714313003393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714313003394 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 714313003395 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714313003396 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714313003397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313003398 NAD binding site [chemical binding]; other site 714313003399 dimer interface [polypeptide binding]; other site 714313003400 substrate binding site [chemical binding]; other site 714313003401 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 714313003402 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 714313003403 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 714313003404 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 714313003405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313003406 dimer interface [polypeptide binding]; other site 714313003407 conserved gate region; other site 714313003408 putative PBP binding loops; other site 714313003409 ABC-ATPase subunit interface; other site 714313003410 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 714313003411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313003412 dimer interface [polypeptide binding]; other site 714313003413 conserved gate region; other site 714313003414 ABC-ATPase subunit interface; other site 714313003415 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 714313003416 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 714313003417 Walker A/P-loop; other site 714313003418 ATP binding site [chemical binding]; other site 714313003419 Q-loop/lid; other site 714313003420 ABC transporter signature motif; other site 714313003421 Walker B; other site 714313003422 D-loop; other site 714313003423 H-loop/switch region; other site 714313003424 seryl-tRNA synthetase; Provisional; Region: PRK05431 714313003425 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 714313003426 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 714313003427 dimer interface [polypeptide binding]; other site 714313003428 active site 714313003429 motif 1; other site 714313003430 motif 2; other site 714313003431 motif 3; other site 714313003432 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714313003433 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714313003434 Substrate-binding site [chemical binding]; other site 714313003435 Substrate specificity [chemical binding]; other site 714313003436 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 714313003437 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 714313003438 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 714313003439 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 714313003440 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714313003441 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 714313003442 active site 714313003443 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714313003444 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 714313003445 HTH-like domain; Region: HTH_21; pfam13276 714313003446 Integrase core domain; Region: rve; pfam00665 714313003447 Integrase core domain; Region: rve_2; pfam13333 714313003448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003449 Homeodomain-like domain; Region: HTH_23; cl17451 714313003450 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003451 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 714313003452 metal binding site [ion binding]; metal-binding site 714313003453 dimer interface [polypeptide binding]; other site 714313003454 amidophosphoribosyltransferase; Region: PLN02440 714313003455 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 714313003456 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 714313003457 active site 714313003458 DNA binding site [nucleotide binding] 714313003459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714313003460 Ligand Binding Site [chemical binding]; other site 714313003461 BCCT family transporter; Region: BCCT; pfam02028 714313003462 maltose O-acetyltransferase; Provisional; Region: PRK10092 714313003463 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 714313003464 active site 714313003465 substrate binding site [chemical binding]; other site 714313003466 trimer interface [polypeptide binding]; other site 714313003467 CoA binding site [chemical binding]; other site 714313003468 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 714313003469 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 714313003470 RNA/DNA hybrid binding site [nucleotide binding]; other site 714313003471 active site 714313003472 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714313003473 dimer interface [polypeptide binding]; other site 714313003474 substrate binding site [chemical binding]; other site 714313003475 ATP binding site [chemical binding]; other site 714313003476 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 714313003477 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714313003478 DNA-binding site [nucleotide binding]; DNA binding site 714313003479 RNA-binding motif; other site 714313003480 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714313003481 DNA-binding site [nucleotide binding]; DNA binding site 714313003482 RNA-binding motif; other site 714313003483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714313003484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714313003485 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 714313003486 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 714313003487 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 714313003488 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 714313003489 NAD binding site [chemical binding]; other site 714313003490 homotetramer interface [polypeptide binding]; other site 714313003491 homodimer interface [polypeptide binding]; other site 714313003492 substrate binding site [chemical binding]; other site 714313003493 active site 714313003494 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 714313003495 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 714313003496 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 714313003497 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 714313003498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714313003499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714313003500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 714313003501 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714313003502 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 714313003503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714313003504 carboxyltransferase (CT) interaction site; other site 714313003505 biotinylation site [posttranslational modification]; other site 714313003506 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 714313003507 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714313003508 dimer interface [polypeptide binding]; other site 714313003509 active site 714313003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714313003511 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 714313003512 NAD(P) binding site [chemical binding]; other site 714313003513 active site 714313003514 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 714313003515 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714313003516 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714313003517 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 714313003518 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714313003519 dimer interface [polypeptide binding]; other site 714313003520 active site 714313003521 CoA binding pocket [chemical binding]; other site 714313003522 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714313003523 Predicted membrane protein [Function unknown]; Region: COG2364 714313003524 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714313003525 fumarate hydratase; Reviewed; Region: fumC; PRK00485 714313003526 Class II fumarases; Region: Fumarase_classII; cd01362 714313003527 active site 714313003528 tetramer interface [polypeptide binding]; other site 714313003529 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 714313003530 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 714313003531 GDP-binding site [chemical binding]; other site 714313003532 ACT binding site; other site 714313003533 IMP binding site; other site 714313003534 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 714313003535 acyl carrier protein; Provisional; Region: acpP; PRK00982 714313003536 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 714313003537 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714313003538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313003539 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313003540 Probable transposase; Region: OrfB_IS605; pfam01385 714313003541 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313003542 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313003543 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714313003544 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714313003545 active site 714313003546 catalytic tetrad [active] 714313003547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003548 Homeodomain-like domain; Region: HTH_23; cl17451 714313003549 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003550 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 714313003551 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 714313003552 NAD binding site [chemical binding]; other site 714313003553 substrate binding site [chemical binding]; other site 714313003554 catalytic Zn binding site [ion binding]; other site 714313003555 tetramer interface [polypeptide binding]; other site 714313003556 structural Zn binding site [ion binding]; other site 714313003557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714313003558 active site 714313003559 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 714313003560 active site 714313003561 dimer interface [polypeptide binding]; other site 714313003562 benzoate transport; Region: 2A0115; TIGR00895 714313003563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313003564 putative substrate translocation pore; other site 714313003565 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 714313003566 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714313003567 EamA-like transporter family; Region: EamA; cl17759 714313003568 EamA-like transporter family; Region: EamA; pfam00892 714313003569 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714313003570 EamA-like transporter family; Region: EamA; pfam00892 714313003571 EamA-like transporter family; Region: EamA; pfam00892 714313003572 Transport protein; Region: actII; TIGR00833 714313003573 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714313003574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714313003575 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 714313003576 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 714313003577 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 714313003578 NAD binding site [chemical binding]; other site 714313003579 homodimer interface [polypeptide binding]; other site 714313003580 active site 714313003581 substrate binding site [chemical binding]; other site 714313003582 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 714313003583 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 714313003584 active site 714313003585 substrate binding site [chemical binding]; other site 714313003586 metal binding site [ion binding]; metal-binding site 714313003587 stage V sporulation protein K; Region: spore_V_K; TIGR02881 714313003588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003589 Walker A motif; other site 714313003590 ATP binding site [chemical binding]; other site 714313003591 Walker B motif; other site 714313003592 arginine finger; other site 714313003593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714313003594 putative substrate translocation pore; other site 714313003595 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714313003596 catalytic core [active] 714313003597 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 714313003598 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 714313003599 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 714313003600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714313003601 NAD(P) binding site [chemical binding]; other site 714313003602 active site 714313003603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003604 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003606 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003607 putative transposase OrfB; Reviewed; Region: PHA02517 714313003608 HTH-like domain; Region: HTH_21; pfam13276 714313003609 Integrase core domain; Region: rve; pfam00665 714313003610 Integrase core domain; Region: rve_2; pfam13333 714313003611 inner membrane transporter YjeM; Provisional; Region: PRK15238 714313003612 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 714313003613 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714313003614 DNA binding site [nucleotide binding] 714313003615 active site 714313003616 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 714313003617 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714313003618 dimer interface [polypeptide binding]; other site 714313003619 FMN binding site [chemical binding]; other site 714313003620 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 714313003621 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 714313003622 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 714313003623 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 714313003624 NAD binding site [chemical binding]; other site 714313003625 Bacterial sugar transferase; Region: Bac_transf; pfam02397 714313003626 Core-2/I-Branching enzyme; Region: Branch; pfam02485 714313003627 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 714313003628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714313003629 UDP-galactopyranose mutase; Region: GLF; pfam03275 714313003630 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 714313003631 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 714313003632 putative ADP-binding pocket [chemical binding]; other site 714313003633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714313003634 active site 714313003635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003636 Homeodomain-like domain; Region: HTH_23; cl17451 714313003637 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003638 HTH-like domain; Region: HTH_21; pfam13276 714313003639 Integrase core domain; Region: rve; pfam00665 714313003640 Integrase core domain; Region: rve_2; pfam13333 714313003641 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714313003642 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 714313003643 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 714313003644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714313003645 UDP-galactopyranose mutase; Region: GLF; pfam03275 714313003646 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 714313003647 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 714313003648 Probable Catalytic site; other site 714313003649 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 714313003650 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714313003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003652 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714313003653 Walker A motif; other site 714313003654 ATP binding site [chemical binding]; other site 714313003655 Walker B motif; other site 714313003656 arginine finger; other site 714313003657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714313003658 Walker A motif; other site 714313003659 ATP binding site [chemical binding]; other site 714313003660 Walker B motif; other site 714313003661 arginine finger; other site 714313003662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 714313003663 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 714313003664 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714313003665 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714313003666 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 714313003667 Chain length determinant protein; Region: Wzz; cl15801 714313003668 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714313003669 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714313003670 active site 714313003671 tetramer interface; other site 714313003672 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714313003673 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 714313003674 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714313003675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313003676 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313003677 Probable transposase; Region: OrfB_IS605; pfam01385 714313003678 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313003679 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313003680 Cadmium resistance transporter; Region: Cad; pfam03596 714313003681 Winged helix-turn helix; Region: HTH_29; pfam13551 714313003682 HTH-like domain; Region: HTH_21; pfam13276 714313003683 Integrase core domain; Region: rve; pfam00665 714313003684 DDE domain; Region: DDE_Tnp_IS240; pfam13610 714313003685 Integrase core domain; Region: rve_2; pfam13333 714313003686 Predicted transcriptional regulators [Transcription]; Region: COG1733 714313003687 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714313003688 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 714313003689 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714313003690 active site 714313003691 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 714313003692 glycerate kinase; Region: TIGR00045 714313003693 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 714313003694 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714313003695 CoenzymeA binding site [chemical binding]; other site 714313003696 subunit interaction site [polypeptide binding]; other site 714313003697 PHB binding site; other site 714313003698 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714313003699 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 714313003700 substrate binding site [chemical binding]; other site 714313003701 oxyanion hole (OAH) forming residues; other site 714313003702 trimer interface [polypeptide binding]; other site 714313003703 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 714313003704 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 714313003705 acyl-activating enzyme (AAE) consensus motif; other site 714313003706 putative AMP binding site [chemical binding]; other site 714313003707 putative active site [active] 714313003708 putative CoA binding site [chemical binding]; other site 714313003709 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 714313003710 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 714313003711 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 714313003712 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 714313003713 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 714313003714 citrate lyase subunit gamma; Provisional; Region: PRK13253 714313003715 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 714313003716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714313003717 active site 714313003718 nucleotide binding site [chemical binding]; other site 714313003719 HIGH motif; other site 714313003720 KMSKS motif; other site 714313003721 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 714313003722 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714313003723 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 714313003724 NAD(P) binding pocket [chemical binding]; other site 714313003725 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 714313003726 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714313003727 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714313003728 NAD binding site [chemical binding]; other site 714313003729 dimer interface [polypeptide binding]; other site 714313003730 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714313003731 substrate binding site [chemical binding]; other site 714313003732 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 714313003733 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 714313003734 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 714313003735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714313003736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714313003737 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 714313003738 Walker A/P-loop; other site 714313003739 ATP binding site [chemical binding]; other site 714313003740 Q-loop/lid; other site 714313003741 ABC transporter signature motif; other site 714313003742 Walker B; other site 714313003743 D-loop; other site 714313003744 H-loop/switch region; other site 714313003745 xanthine permease; Region: pbuX; TIGR03173 714313003746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003747 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003749 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003750 Haemolysin-III related; Region: HlyIII; cl03831 714313003751 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 714313003752 LytTr DNA-binding domain; Region: LytTR; smart00850 714313003753 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 714313003754 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 714313003755 Transferrin; Region: Transferrin; cl02460 714313003756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714313003757 membrane-bound complex binding site; other site 714313003758 Predicted membrane protein [Function unknown]; Region: COG2855 714313003759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714313003760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714313003761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714313003762 dimerization interface [polypeptide binding]; other site 714313003763 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 714313003764 Part of AAA domain; Region: AAA_19; pfam13245 714313003765 Family description; Region: UvrD_C_2; pfam13538 714313003766 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 714313003767 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 714313003768 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 714313003769 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714313003770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714313003771 NAD(P) binding site [chemical binding]; other site 714313003772 active site 714313003773 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714313003774 HTH-like domain; Region: HTH_21; pfam13276 714313003775 Integrase core domain; Region: rve; pfam00665 714313003776 Integrase core domain; Region: rve_2; pfam13333 714313003777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003778 Homeodomain-like domain; Region: HTH_23; cl17451 714313003779 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003780 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 714313003781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313003782 dimer interface [polypeptide binding]; other site 714313003783 conserved gate region; other site 714313003784 putative PBP binding loops; other site 714313003785 ABC-ATPase subunit interface; other site 714313003786 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714313003787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714313003788 dimer interface [polypeptide binding]; other site 714313003789 conserved gate region; other site 714313003790 putative PBP binding loops; other site 714313003791 ABC-ATPase subunit interface; other site 714313003792 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714313003793 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714313003794 substrate binding pocket [chemical binding]; other site 714313003795 membrane-bound complex binding site; other site 714313003796 hinge residues; other site 714313003797 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714313003798 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714313003799 Walker A/P-loop; other site 714313003800 ATP binding site [chemical binding]; other site 714313003801 Q-loop/lid; other site 714313003802 ABC transporter signature motif; other site 714313003803 Walker B; other site 714313003804 D-loop; other site 714313003805 H-loop/switch region; other site 714313003806 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 714313003807 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 714313003808 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714313003809 putative active site [active] 714313003810 catalytic site [active] 714313003811 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714313003812 putative active site [active] 714313003813 catalytic site [active] 714313003814 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 714313003815 trimer interface [polypeptide binding]; other site 714313003816 active site 714313003817 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714313003818 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714313003819 Catalytic site [active] 714313003820 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714313003821 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 714313003822 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 714313003823 substrate binding pocket [chemical binding]; other site 714313003824 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714313003825 EamA-like transporter family; Region: EamA; pfam00892 714313003826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714313003827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714313003828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714313003829 dimerization interface [polypeptide binding]; other site 714313003830 PemK-like protein; Region: PemK; cl00995 714313003831 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 714313003832 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 714313003833 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 714313003834 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 714313003835 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 714313003836 trmE is a tRNA modification GTPase; Region: trmE; cd04164 714313003837 G1 box; other site 714313003838 GTP/Mg2+ binding site [chemical binding]; other site 714313003839 Switch I region; other site 714313003840 G2 box; other site 714313003841 Switch II region; other site 714313003842 G3 box; other site 714313003843 G4 box; other site 714313003844 G5 box; other site 714313003845 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 714313003846 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 714313003847 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 714313003848 G-X-X-G motif; other site 714313003849 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 714313003850 RxxxH motif; other site 714313003851 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714313003852 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 714313003853 ribonuclease P; Reviewed; Region: rnpA; PRK00499 714313003854 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 714313003855 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 714313003856 Alba; Region: Alba; cl00682 714313003857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 714313003858 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714313003859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714313003860 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714313003861 Probable transposase; Region: OrfB_IS605; pfam01385 714313003862 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313003863 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 714313003864 CrcB-like protein; Region: CRCB; pfam02537 714313003865 CrcB-like protein; Region: CRCB; cl09114 714313003866 Integrase core domain; Region: rve; pfam00665 714313003867 Integrase core domain; Region: rve_3; pfam13683 714313003868 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714313003869 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714313003870 catalytic residues [active] 714313003871 catalytic nucleophile [active] 714313003872 Presynaptic Site I dimer interface [polypeptide binding]; other site 714313003873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714313003874 Synaptic Flat tetramer interface [polypeptide binding]; other site 714313003875 Synaptic Site I dimer interface [polypeptide binding]; other site 714313003876 DNA binding site [nucleotide binding] 714313003877 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 714313003878 DNA-binding interface [nucleotide binding]; DNA binding site 714313003879 Isochorismatase family; Region: Isochorismatase; pfam00857 714313003880 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714313003881 catalytic triad [active] 714313003882 conserved cis-peptide bond; other site 714313003883 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 714313003884 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 714313003885 active site 714313003886 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 714313003887 nudix motif; other site 714313003888 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 714313003889 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 714313003890 Helix-turn-helix domain; Region: HTH_38; pfam13936 714313003891 Integrase core domain; Region: rve; pfam00665 714313003892 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 714313003893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714313003894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714313003895 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714313003896 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 714313003897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 714313003898 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 714313003899 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 714313003900 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 714313003901 CT1975-like protein; Region: Cas_CT1975; pfam09344 714313003902 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 714313003903 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 714313003904 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 714313003905 Probable transposase; Region: OrfB_IS605; pfam01385 714313003906 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714313003907 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714313003908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003909 Transposase; Region: HTH_Tnp_1; pfam01527 714313003910 putative transposase OrfB; Reviewed; Region: PHA02517 714313003911 HTH-like domain; Region: HTH_21; pfam13276 714313003912 Integrase core domain; Region: rve; pfam00665 714313003913 Integrase core domain; Region: rve_3; pfam13683 714313003914 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714313003915 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714313003916 putative NAD(P) binding site [chemical binding]; other site 714313003917 Initiator Replication protein; Region: Rep_3; pfam01051 714313003918 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 714313003919 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 714313003920 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 714313003921 HNH endonuclease; Region: HNH_2; pfam13391 714313003922 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 714313003923 GIY-YIG motif/motif A; other site 714313003924 active site 714313003925 catalytic site [active] 714313003926 metal binding site [ion binding]; metal-binding site 714313003927 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 714313003928 Uncharacterized conserved protein [Function unknown]; Region: COG3410 714313003929 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 714313003930 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 714313003931 Na binding site [ion binding]; other site 714313003932 cytosine deaminase; Provisional; Region: PRK09230 714313003933 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 714313003934 active site 714313003935 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714313003936 IHF - DNA interface [nucleotide binding]; other site 714313003937 IHF dimer interface [polypeptide binding]; other site 714313003938 potential frameshift: common BLAST hit: gi|330818953|ref|YP_004385932.1| transposase mutator type 714313003939 Transposase, Mutator family; Region: Transposase_mut; pfam00872 714313003940 Transposase, Mutator family; Region: Transposase_mut; pfam00872 714313003941 MULE transposase domain; Region: MULE; pfam10551 714313003942 Protein of unknown function (DUF436); Region: DUF436; pfam04260 714313003943 putative transposase OrfB; Reviewed; Region: PHA02517 714313003944 HTH-like domain; Region: HTH_21; pfam13276 714313003945 Integrase core domain; Region: rve_3; pfam13683 714313003946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003947 Transposase; Region: HTH_Tnp_1; pfam01527 714313003948 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714313003949 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714313003950 catalytic residues [active] 714313003951 catalytic nucleophile [active] 714313003952 Presynaptic Site I dimer interface [polypeptide binding]; other site 714313003953 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714313003954 Synaptic Flat tetramer interface [polypeptide binding]; other site 714313003955 Synaptic Site I dimer interface [polypeptide binding]; other site 714313003956 DNA binding site [nucleotide binding] 714313003957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003958 Transposase; Region: HTH_Tnp_1; pfam01527 714313003959 HTH-like domain; Region: HTH_21; pfam13276 714313003960 Integrase core domain; Region: rve; pfam00665 714313003961 DDE domain; Region: DDE_Tnp_IS240; pfam13610 714313003962 Integrase core domain; Region: rve_2; pfam13333 714313003963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714313003964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714313003965 P-loop; other site 714313003966 Magnesium ion binding site [ion binding]; other site 714313003967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714313003968 Magnesium ion binding site [ion binding]; other site 714313003969 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714313003970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714313003971 Magnesium ion binding site [ion binding]; other site 714313003972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 714313003973 HTH-like domain; Region: HTH_21; pfam13276 714313003974 Integrase core domain; Region: rve; pfam00665 714313003975 Integrase core domain; Region: rve_3; cl15866 714313003976 Transposase; Region: HTH_Tnp_1; pfam01527 714313003977 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 714313003978 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 714313003979 active site 714313003980 purine riboside binding site [chemical binding]; other site 714313003981 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714313003982 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 714313003983 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714313003984 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714313003985 active site 714313003986 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 714313003987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714313003988 active site 714313003989 DNA binding site [nucleotide binding] 714313003990 Int/Topo IB signature motif; other site 714313003991 HTH-like domain; Region: HTH_21; pfam13276 714313003992 Integrase core domain; Region: rve; pfam00665 714313003993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714313003994 Helix-turn-helix domain; Region: HTH_28; pfam13518 714313003995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714313003996 non-specific DNA binding site [nucleotide binding]; other site 714313003997 salt bridge; other site 714313003998 sequence-specific DNA binding site [nucleotide binding]; other site 714313003999 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714313004000 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 714313004001 cofactor binding site; other site 714313004002 DNA binding site [nucleotide binding] 714313004003 substrate interaction site [chemical binding]; other site 714313004004 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737