-- dump date 20140619_125643 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1046624000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1046624000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624000003 Walker A motif; other site 1046624000004 ATP binding site [chemical binding]; other site 1046624000005 Walker B motif; other site 1046624000006 arginine finger; other site 1046624000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1046624000008 DnaA box-binding interface [nucleotide binding]; other site 1046624000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1046624000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1046624000011 putative DNA binding surface [nucleotide binding]; other site 1046624000012 dimer interface [polypeptide binding]; other site 1046624000013 beta-clamp/clamp loader binding surface; other site 1046624000014 beta-clamp/translesion DNA polymerase binding surface; other site 1046624000015 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1046624000016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1046624000017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1046624000018 Part of AAA domain; Region: AAA_19; pfam13245 1046624000019 Family description; Region: UvrD_C_2; pfam13538 1046624000020 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1046624000021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624000022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000023 non-specific DNA binding site [nucleotide binding]; other site 1046624000024 salt bridge; other site 1046624000025 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000026 GTP-binding protein YchF; Reviewed; Region: PRK09601 1046624000027 YchF GTPase; Region: YchF; cd01900 1046624000028 G1 box; other site 1046624000029 GTP/Mg2+ binding site [chemical binding]; other site 1046624000030 Switch I region; other site 1046624000031 G2 box; other site 1046624000032 Switch II region; other site 1046624000033 G3 box; other site 1046624000034 G4 box; other site 1046624000035 G5 box; other site 1046624000036 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1046624000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000038 non-specific DNA binding site [nucleotide binding]; other site 1046624000039 salt bridge; other site 1046624000040 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000041 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1046624000042 AAA domain; Region: AAA_17; pfam13207 1046624000043 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1046624000044 putative active site [active] 1046624000045 catalytic residue [active] 1046624000046 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1046624000047 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1046624000048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624000049 ATP binding site [chemical binding]; other site 1046624000050 putative Mg++ binding site [ion binding]; other site 1046624000051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624000052 nucleotide binding region [chemical binding]; other site 1046624000053 ATP-binding site [chemical binding]; other site 1046624000054 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1046624000055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624000056 RNA binding surface [nucleotide binding]; other site 1046624000057 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1046624000058 Septum formation initiator; Region: DivIC; cl17659 1046624000059 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1046624000060 RNA binding site [nucleotide binding]; other site 1046624000061 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1046624000062 SH3-like domain; Region: SH3_8; pfam13457 1046624000063 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1046624000064 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1046624000065 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1046624000066 Ligand Binding Site [chemical binding]; other site 1046624000067 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1046624000068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624000069 active site 1046624000070 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1046624000071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624000072 Walker A motif; other site 1046624000073 ATP binding site [chemical binding]; other site 1046624000074 Walker B motif; other site 1046624000075 arginine finger; other site 1046624000076 Peptidase family M41; Region: Peptidase_M41; pfam01434 1046624000077 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1046624000078 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1046624000079 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1046624000080 active site 1046624000081 P-loop; other site 1046624000082 phosphorylation site [posttranslational modification] 1046624000083 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1046624000084 active site 1046624000085 P-loop; other site 1046624000086 phosphorylation site [posttranslational modification] 1046624000087 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1046624000088 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1046624000089 PRD domain; Region: PRD; pfam00874 1046624000090 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1046624000091 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1046624000092 active site 1046624000093 phosphorylation site [posttranslational modification] 1046624000094 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1046624000095 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1046624000096 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1046624000097 putative nonsense mutation 1046624000098 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1046624000099 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1046624000100 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1046624000101 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1046624000102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624000103 Coenzyme A binding pocket [chemical binding]; other site 1046624000104 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1046624000105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624000106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624000107 homodimer interface [polypeptide binding]; other site 1046624000108 catalytic residue [active] 1046624000109 Recombination protein O N terminal; Region: RecO_N; pfam11967 1046624000110 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1046624000111 Recombination protein O C terminal; Region: RecO_C; pfam02565 1046624000112 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1046624000113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1046624000114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624000115 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1046624000116 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1046624000117 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1046624000118 E3 interaction surface; other site 1046624000119 lipoyl attachment site [posttranslational modification]; other site 1046624000120 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1046624000121 E3 interaction surface; other site 1046624000122 lipoyl attachment site [posttranslational modification]; other site 1046624000123 e3 binding domain; Region: E3_binding; pfam02817 1046624000124 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1046624000125 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1046624000126 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1046624000127 TPP binding site [chemical binding]; other site 1046624000128 alpha subunit interface [polypeptide binding]; other site 1046624000129 heterodimer interface [polypeptide binding]; other site 1046624000130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1046624000131 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1046624000132 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1046624000133 tetramer interface [polypeptide binding]; other site 1046624000134 TPP-binding site [chemical binding]; other site 1046624000135 heterodimer interface [polypeptide binding]; other site 1046624000136 phosphorylation loop region [posttranslational modification] 1046624000137 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1046624000138 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1046624000139 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1046624000140 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1046624000141 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1046624000142 active site 1046624000143 catalytic site [active] 1046624000144 metal binding site [ion binding]; metal-binding site 1046624000145 dimer interface [polypeptide binding]; other site 1046624000146 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1046624000147 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624000148 Zn2+ binding site [ion binding]; other site 1046624000149 Mg2+ binding site [ion binding]; other site 1046624000150 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1046624000151 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1046624000152 active site 1046624000153 HIGH motif; other site 1046624000154 dimer interface [polypeptide binding]; other site 1046624000155 KMSKS motif; other site 1046624000156 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1046624000157 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1046624000158 putative nonsense mutation 1046624000159 putative phosphate acyltransferase; Provisional; Region: PRK05331 1046624000160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1046624000161 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624000162 active site 1046624000163 motif I; other site 1046624000164 motif II; other site 1046624000165 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624000166 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1046624000167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624000168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624000169 ABC transporter; Region: ABC_tran_2; pfam12848 1046624000170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624000171 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1046624000172 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1046624000173 homodimer interface [polypeptide binding]; other site 1046624000174 substrate-cofactor binding pocket; other site 1046624000175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624000176 catalytic residue [active] 1046624000177 short chain dehydrogenase; Validated; Region: PRK06182 1046624000178 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1046624000179 NADP binding site [chemical binding]; other site 1046624000180 active site 1046624000181 steroid binding site; other site 1046624000182 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624000183 Ligand Binding Site [chemical binding]; other site 1046624000184 Predicted esterase [General function prediction only]; Region: COG0400 1046624000185 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1046624000186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624000187 Zn binding site [ion binding]; other site 1046624000188 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1046624000189 Zn binding site [ion binding]; other site 1046624000190 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1046624000191 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1046624000192 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1046624000193 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1046624000194 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624000195 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1046624000196 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1046624000197 ParB-like nuclease domain; Region: ParBc; pfam02195 1046624000198 KorB domain; Region: KorB; pfam08535 1046624000199 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 1046624000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624000201 Walker A motif; other site 1046624000202 ATP binding site [chemical binding]; other site 1046624000203 Walker B motif; other site 1046624000204 arginine finger; other site 1046624000205 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1046624000206 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1046624000207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624000208 Coenzyme A binding pocket [chemical binding]; other site 1046624000209 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1046624000210 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1046624000211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624000212 Walker A/P-loop; other site 1046624000213 ATP binding site [chemical binding]; other site 1046624000214 Q-loop/lid; other site 1046624000215 ABC transporter signature motif; other site 1046624000216 Walker B; other site 1046624000217 D-loop; other site 1046624000218 H-loop/switch region; other site 1046624000219 ABC transporter; Region: ABC_tran_2; pfam12848 1046624000220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624000221 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1046624000222 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1046624000223 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1046624000224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624000225 S-adenosylmethionine binding site [chemical binding]; other site 1046624000226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1046624000227 RNA methyltransferase, RsmE family; Region: TIGR00046 1046624000228 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1046624000229 putative active site [active] 1046624000230 putative metal binding site [ion binding]; other site 1046624000231 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1046624000232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624000233 Zn2+ binding site [ion binding]; other site 1046624000234 Mg2+ binding site [ion binding]; other site 1046624000235 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1046624000236 synthetase active site [active] 1046624000237 NTP binding site [chemical binding]; other site 1046624000238 metal binding site [ion binding]; metal-binding site 1046624000239 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1046624000240 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1046624000241 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1046624000242 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1046624000243 Ligand binding site; other site 1046624000244 Putative Catalytic site; other site 1046624000245 DXD motif; other site 1046624000246 Predicted integral membrane protein [Function unknown]; Region: COG3548 1046624000247 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1046624000248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624000249 amino acid transporter; Region: 2A0306; TIGR00909 1046624000250 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1046624000251 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1046624000252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1046624000253 putative acyl-acceptor binding pocket; other site 1046624000254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624000255 MarR family; Region: MarR_2; cl17246 1046624000256 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1046624000257 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1046624000258 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1046624000259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624000260 nucleotide binding region [chemical binding]; other site 1046624000261 ATP-binding site [chemical binding]; other site 1046624000262 SEC-C motif; Region: SEC-C; pfam02810 1046624000263 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 1046624000264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1046624000265 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1046624000266 dimerization domain swap beta strand [polypeptide binding]; other site 1046624000267 regulatory protein interface [polypeptide binding]; other site 1046624000268 active site 1046624000269 regulatory phosphorylation site [posttranslational modification]; other site 1046624000270 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1046624000271 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1046624000272 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1046624000273 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1046624000274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1046624000275 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1046624000276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1046624000277 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1046624000278 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1046624000279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000280 putative substrate translocation pore; other site 1046624000281 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1046624000282 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1046624000283 Ligand binding site; other site 1046624000284 Putative Catalytic site; other site 1046624000285 DXD motif; other site 1046624000286 argininosuccinate synthase; Provisional; Region: PRK13820 1046624000287 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1046624000288 ANP binding site [chemical binding]; other site 1046624000289 Substrate Binding Site II [chemical binding]; other site 1046624000290 Substrate Binding Site I [chemical binding]; other site 1046624000291 argininosuccinate lyase; Provisional; Region: PRK00855 1046624000292 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1046624000293 active sites [active] 1046624000294 tetramer interface [polypeptide binding]; other site 1046624000295 drug efflux system protein MdtG; Provisional; Region: PRK09874 1046624000296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000297 putative substrate translocation pore; other site 1046624000298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624000299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624000300 WHG domain; Region: WHG; pfam13305 1046624000301 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1046624000302 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1046624000303 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1046624000304 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1046624000305 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1046624000306 G-X-X-G motif; other site 1046624000307 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 1046624000308 RxxxH motif; other site 1046624000309 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1046624000310 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624000311 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624000312 active site 1046624000313 catalytic tetrad [active] 1046624000314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000315 non-specific DNA binding site [nucleotide binding]; other site 1046624000316 salt bridge; other site 1046624000317 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000318 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1046624000319 CAAX protease self-immunity; Region: Abi; pfam02517 1046624000320 hypothetical protein; Provisional; Region: PRK05473 1046624000321 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1046624000322 hypothetical protein; Provisional; Region: PRK13678 1046624000323 Predicted integral membrane protein [Function unknown]; Region: COG3548 1046624000324 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1046624000325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624000326 NAD(P) binding site [chemical binding]; other site 1046624000327 active site 1046624000328 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1046624000329 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1046624000330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624000331 NAD(P) binding site [chemical binding]; other site 1046624000332 active site 1046624000333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624000334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624000335 putative DNA binding site [nucleotide binding]; other site 1046624000336 putative Zn2+ binding site [ion binding]; other site 1046624000337 glycogen branching enzyme; Provisional; Region: PRK12313 1046624000338 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 1046624000339 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 1046624000340 active site 1046624000341 catalytic site [active] 1046624000342 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1046624000343 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1046624000344 Collagen binding domain; Region: Collagen_bind; pfam05737 1046624000345 Collagen binding domain; Region: Collagen_bind; pfam05737 1046624000346 Collagen binding domain; Region: Collagen_bind; pfam05737 1046624000347 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000348 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000349 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000350 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1046624000351 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000352 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000353 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000354 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000355 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000356 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624000357 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1046624000358 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1046624000359 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1046624000360 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624000361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624000362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000363 non-specific DNA binding site [nucleotide binding]; other site 1046624000364 salt bridge; other site 1046624000365 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000366 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1046624000367 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1046624000368 Protein of unknown function (DUF975); Region: DUF975; cl10504 1046624000369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624000371 putative substrate translocation pore; other site 1046624000372 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1046624000373 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1046624000374 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1046624000375 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1046624000376 aminotransferase AlaT; Validated; Region: PRK09265 1046624000377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624000378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624000379 homodimer interface [polypeptide binding]; other site 1046624000380 catalytic residue [active] 1046624000381 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 1046624000382 CodY GAF-like domain; Region: CodY; pfam06018 1046624000383 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1046624000384 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1046624000385 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1046624000386 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1046624000387 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1046624000388 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1046624000389 nudix motif; other site 1046624000390 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1046624000391 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1046624000392 GatB domain; Region: GatB_Yqey; pfam02637 1046624000393 amidase; Provisional; Region: PRK06529 1046624000394 Amidase; Region: Amidase; cl11426 1046624000395 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1046624000396 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1046624000397 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1046624000398 DNA-binding site [nucleotide binding]; DNA binding site 1046624000399 RNA-binding motif; other site 1046624000400 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1046624000401 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1046624000402 Rhomboid family; Region: Rhomboid; pfam01694 1046624000403 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1046624000404 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1046624000405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1046624000406 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1046624000407 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1046624000408 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1046624000409 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1046624000410 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1046624000411 beta-galactosidase; Region: BGL; TIGR03356 1046624000412 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1046624000413 trimer interface [polypeptide binding]; other site 1046624000414 active site 1046624000415 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1046624000416 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1046624000417 active site 1046624000418 metal binding site [ion binding]; metal-binding site 1046624000419 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1046624000420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1046624000421 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1046624000422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624000423 FeS/SAM binding site; other site 1046624000424 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1046624000425 dimer interface [polypeptide binding]; other site 1046624000426 FMN binding site [chemical binding]; other site 1046624000427 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1046624000428 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1046624000429 substrate binding pocket [chemical binding]; other site 1046624000430 chain length determination region; other site 1046624000431 substrate-Mg2+ binding site; other site 1046624000432 catalytic residues [active] 1046624000433 aspartate-rich region 1; other site 1046624000434 active site lid residues [active] 1046624000435 aspartate-rich region 2; other site 1046624000436 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1046624000437 UbiA prenyltransferase family; Region: UbiA; pfam01040 1046624000438 CAAX protease self-immunity; Region: Abi; pfam02517 1046624000439 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1046624000440 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1046624000441 G1 box; other site 1046624000442 GTP/Mg2+ binding site [chemical binding]; other site 1046624000443 Switch I region; other site 1046624000444 G2 box; other site 1046624000445 G3 box; other site 1046624000446 Switch II region; other site 1046624000447 G4 box; other site 1046624000448 G5 box; other site 1046624000449 Nucleoside recognition; Region: Gate; pfam07670 1046624000450 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1046624000451 Nucleoside recognition; Region: Gate; pfam07670 1046624000452 FeoA domain; Region: FeoA; pfam04023 1046624000453 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1046624000454 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1046624000455 SelR domain; Region: SelR; pfam01641 1046624000456 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1046624000457 DAK2 domain; Region: Dak2; pfam02734 1046624000458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1046624000459 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1046624000460 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 1046624000461 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1046624000462 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1046624000463 substrate binding site; other site 1046624000464 tetramer interface; other site 1046624000465 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1046624000466 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1046624000467 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1046624000468 NAD binding site [chemical binding]; other site 1046624000469 substrate binding site [chemical binding]; other site 1046624000470 homodimer interface [polypeptide binding]; other site 1046624000471 active site 1046624000472 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1046624000473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624000474 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1046624000475 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1046624000476 NADP binding site [chemical binding]; other site 1046624000477 active site 1046624000478 putative substrate binding site [chemical binding]; other site 1046624000479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1046624000480 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1046624000481 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1046624000482 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1046624000483 Probable Catalytic site; other site 1046624000484 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1046624000485 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1046624000486 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1046624000487 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1046624000488 Walker A/P-loop; other site 1046624000489 ATP binding site [chemical binding]; other site 1046624000490 Q-loop/lid; other site 1046624000491 ABC transporter signature motif; other site 1046624000492 Walker B; other site 1046624000493 D-loop; other site 1046624000494 H-loop/switch region; other site 1046624000495 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1046624000496 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1046624000497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1046624000498 active site 1046624000499 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1046624000500 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1046624000501 Ligand binding site; other site 1046624000502 Putative Catalytic site; other site 1046624000503 DXD motif; other site 1046624000504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1046624000505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1046624000506 active site 1046624000507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1046624000508 active site 1046624000509 LicD family; Region: LicD; pfam04991 1046624000510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1046624000511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624000512 NAD(P) binding site [chemical binding]; other site 1046624000513 active site 1046624000514 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1046624000515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1046624000516 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1046624000517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1046624000518 UDP-galactopyranose mutase; Region: GLF; pfam03275 1046624000519 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1046624000520 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1046624000521 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1046624000522 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1046624000523 active site 1046624000524 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1046624000525 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1046624000526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1046624000527 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1046624000528 active site 1046624000529 GTPase YqeH; Provisional; Region: PRK13796 1046624000530 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1046624000531 GTP/Mg2+ binding site [chemical binding]; other site 1046624000532 G4 box; other site 1046624000533 G5 box; other site 1046624000534 G1 box; other site 1046624000535 Switch I region; other site 1046624000536 G2 box; other site 1046624000537 G3 box; other site 1046624000538 Switch II region; other site 1046624000539 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1046624000540 nudix motif; other site 1046624000541 GTPases [General function prediction only]; Region: HflX; COG2262 1046624000542 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1046624000543 HflX GTPase family; Region: HflX; cd01878 1046624000544 G1 box; other site 1046624000545 GTP/Mg2+ binding site [chemical binding]; other site 1046624000546 Switch I region; other site 1046624000547 G2 box; other site 1046624000548 G3 box; other site 1046624000549 Switch II region; other site 1046624000550 G4 box; other site 1046624000551 G5 box; other site 1046624000552 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1046624000553 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1046624000554 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1046624000555 active site 1046624000556 (T/H)XGH motif; other site 1046624000557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624000558 Zn2+ binding site [ion binding]; other site 1046624000559 Mg2+ binding site [ion binding]; other site 1046624000560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624000561 Coenzyme A binding pocket [chemical binding]; other site 1046624000562 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1046624000563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624000564 S-adenosylmethionine binding site [chemical binding]; other site 1046624000565 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1046624000566 hypothetical protein; Provisional; Region: PRK13670 1046624000567 hypothetical protein; Provisional; Region: PRK12378 1046624000568 Uncharacterized conserved protein [Function unknown]; Region: COG4832 1046624000569 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1046624000570 ligand binding site [chemical binding]; other site 1046624000571 active site 1046624000572 UGI interface [polypeptide binding]; other site 1046624000573 catalytic site [active] 1046624000574 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1046624000575 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1046624000576 putative NAD(P) binding site [chemical binding]; other site 1046624000577 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1046624000578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624000579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000580 putative substrate translocation pore; other site 1046624000581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000582 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1046624000583 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1046624000584 DNA binding residues [nucleotide binding] 1046624000585 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1046624000586 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624000587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624000588 active site 1046624000589 motif I; other site 1046624000590 motif II; other site 1046624000591 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624000592 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1046624000593 Phosphoglycerate kinase; Region: PGK; pfam00162 1046624000594 substrate binding site [chemical binding]; other site 1046624000595 hinge regions; other site 1046624000596 ADP binding site [chemical binding]; other site 1046624000597 catalytic site [active] 1046624000598 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 1046624000599 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1046624000600 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1046624000601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624000602 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1046624000603 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1046624000604 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1046624000605 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1046624000606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1046624000607 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1046624000608 amphipathic channel; other site 1046624000609 Asn-Pro-Ala signature motifs; other site 1046624000610 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1046624000611 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1046624000612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1046624000613 Walker A/P-loop; other site 1046624000614 ATP binding site [chemical binding]; other site 1046624000615 Q-loop/lid; other site 1046624000616 ABC transporter signature motif; other site 1046624000617 Walker B; other site 1046624000618 D-loop; other site 1046624000619 H-loop/switch region; other site 1046624000620 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1046624000621 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1046624000622 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1046624000623 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1046624000624 putative RNA binding site [nucleotide binding]; other site 1046624000625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1046624000626 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1046624000627 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1046624000628 HI0933-like protein; Region: HI0933_like; pfam03486 1046624000629 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1046624000630 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1046624000631 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1046624000632 putative substrate binding site [chemical binding]; other site 1046624000633 putative ATP binding site [chemical binding]; other site 1046624000634 Phage envelope protein [General function prediction only]; Region: COG5562 1046624000635 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624000636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624000637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624000638 Walker A/P-loop; other site 1046624000639 ATP binding site [chemical binding]; other site 1046624000640 Q-loop/lid; other site 1046624000641 ABC transporter signature motif; other site 1046624000642 Walker B; other site 1046624000643 D-loop; other site 1046624000644 H-loop/switch region; other site 1046624000645 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624000646 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624000647 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1046624000648 Walker A/P-loop; other site 1046624000649 ATP binding site [chemical binding]; other site 1046624000650 Q-loop/lid; other site 1046624000651 ABC transporter signature motif; other site 1046624000652 Walker B; other site 1046624000653 D-loop; other site 1046624000654 H-loop/switch region; other site 1046624000655 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1046624000656 putative oxidoreductase; Provisional; Region: PRK10206 1046624000657 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1046624000658 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1046624000659 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1046624000660 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1046624000661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624000662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624000663 active site 1046624000664 catalytic tetrad [active] 1046624000665 Isochorismatase family; Region: Isochorismatase; pfam00857 1046624000666 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1046624000667 catalytic triad [active] 1046624000668 conserved cis-peptide bond; other site 1046624000669 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1046624000670 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624000671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624000672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624000673 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1046624000674 ATP cone domain; Region: ATP-cone; pfam03477 1046624000675 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1046624000676 effector binding site; other site 1046624000677 active site 1046624000678 Zn binding site [ion binding]; other site 1046624000679 glycine loop; other site 1046624000680 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1046624000681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624000682 FeS/SAM binding site; other site 1046624000683 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1046624000684 enolase; Provisional; Region: eno; PRK00077 1046624000685 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1046624000686 dimer interface [polypeptide binding]; other site 1046624000687 metal binding site [ion binding]; metal-binding site 1046624000688 substrate binding pocket [chemical binding]; other site 1046624000689 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 1046624000690 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1046624000691 Walker A/P-loop; other site 1046624000692 ATP binding site [chemical binding]; other site 1046624000693 Q-loop/lid; other site 1046624000694 ABC transporter signature motif; other site 1046624000695 Walker B; other site 1046624000696 D-loop; other site 1046624000697 H-loop/switch region; other site 1046624000698 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 1046624000699 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1046624000700 Walker A/P-loop; other site 1046624000701 ATP binding site [chemical binding]; other site 1046624000702 Q-loop/lid; other site 1046624000703 ABC transporter signature motif; other site 1046624000704 Walker B; other site 1046624000705 D-loop; other site 1046624000706 H-loop/switch region; other site 1046624000707 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1046624000708 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1046624000709 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1046624000710 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1046624000711 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1046624000712 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1046624000713 putative trimer interface [polypeptide binding]; other site 1046624000714 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1046624000715 putative CoA binding site [chemical binding]; other site 1046624000716 putative trimer interface [polypeptide binding]; other site 1046624000717 putative CoA binding site [chemical binding]; other site 1046624000718 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1046624000719 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1046624000720 metal binding site [ion binding]; metal-binding site 1046624000721 putative dimer interface [polypeptide binding]; other site 1046624000722 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1046624000723 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1046624000724 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1046624000725 NodB motif; other site 1046624000726 active site 1046624000727 catalytic site [active] 1046624000728 metal binding site [ion binding]; metal-binding site 1046624000729 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1046624000730 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1046624000731 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624000732 RNA binding surface [nucleotide binding]; other site 1046624000733 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1046624000734 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1046624000735 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1046624000736 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1046624000737 RNA binding site [nucleotide binding]; other site 1046624000738 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1046624000739 hypothetical protein; Provisional; Region: PRK04351 1046624000740 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1046624000741 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1046624000742 active site 1046624000743 purine riboside binding site [chemical binding]; other site 1046624000744 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1046624000745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1046624000746 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1046624000747 hypothetical protein; Provisional; Region: PRK13667 1046624000748 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1046624000749 Glycoprotease family; Region: Peptidase_M22; pfam00814 1046624000750 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1046624000751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624000752 Coenzyme A binding pocket [chemical binding]; other site 1046624000753 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1046624000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624000755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1046624000756 Coenzyme A binding pocket [chemical binding]; other site 1046624000757 UGMP family protein; Validated; Region: PRK09604 1046624000758 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1046624000759 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1046624000760 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1046624000761 nucleophilic elbow; other site 1046624000762 catalytic triad; other site 1046624000763 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1046624000764 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1046624000765 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624000766 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624000767 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624000768 putative active site [active] 1046624000769 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1046624000770 amphipathic channel; other site 1046624000771 Asn-Pro-Ala signature motifs; other site 1046624000772 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1046624000773 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1046624000774 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1046624000775 Walker A/P-loop; other site 1046624000776 ATP binding site [chemical binding]; other site 1046624000777 Q-loop/lid; other site 1046624000778 ABC transporter signature motif; other site 1046624000779 Walker B; other site 1046624000780 D-loop; other site 1046624000781 H-loop/switch region; other site 1046624000782 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1046624000783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624000784 dimer interface [polypeptide binding]; other site 1046624000785 conserved gate region; other site 1046624000786 putative PBP binding loops; other site 1046624000787 ABC-ATPase subunit interface; other site 1046624000788 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1046624000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624000790 dimer interface [polypeptide binding]; other site 1046624000791 conserved gate region; other site 1046624000792 ABC-ATPase subunit interface; other site 1046624000793 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1046624000794 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1046624000795 active site 1046624000796 metal binding site [ion binding]; metal-binding site 1046624000797 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1046624000798 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1046624000799 dimer interface [polypeptide binding]; other site 1046624000800 catalytic triad [active] 1046624000801 peroxidatic and resolving cysteines [active] 1046624000802 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1046624000803 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1046624000804 Zn binding site [ion binding]; other site 1046624000805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000806 putative substrate translocation pore; other site 1046624000807 H+ Antiporter protein; Region: 2A0121; TIGR00900 1046624000808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624000809 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1046624000810 Cation efflux family; Region: Cation_efflux; pfam01545 1046624000811 Predicted transcriptional regulators [Transcription]; Region: COG1695 1046624000812 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1046624000813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624000814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624000815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624000816 Walker A/P-loop; other site 1046624000817 ATP binding site [chemical binding]; other site 1046624000818 Q-loop/lid; other site 1046624000819 ABC transporter signature motif; other site 1046624000820 Walker B; other site 1046624000821 D-loop; other site 1046624000822 H-loop/switch region; other site 1046624000823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624000824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624000825 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1046624000826 Walker A/P-loop; other site 1046624000827 ATP binding site [chemical binding]; other site 1046624000828 Q-loop/lid; other site 1046624000829 ABC transporter signature motif; other site 1046624000830 Walker B; other site 1046624000831 D-loop; other site 1046624000832 H-loop/switch region; other site 1046624000833 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1046624000834 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1046624000835 hinge; other site 1046624000836 active site 1046624000837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 1046624000838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000839 non-specific DNA binding site [nucleotide binding]; other site 1046624000840 salt bridge; other site 1046624000841 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000842 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1046624000843 NADPH bind site [chemical binding]; other site 1046624000844 putative FMN binding site [chemical binding]; other site 1046624000845 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1046624000846 putative FMN binding site [chemical binding]; other site 1046624000847 NADPH bind site [chemical binding]; other site 1046624000848 molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355 1046624000849 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1046624000850 ATP binding site [chemical binding]; other site 1046624000851 substrate interface [chemical binding]; other site 1046624000852 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1046624000853 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1046624000854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624000855 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1046624000856 Walker A/P-loop; other site 1046624000857 ATP binding site [chemical binding]; other site 1046624000858 Q-loop/lid; other site 1046624000859 ABC transporter signature motif; other site 1046624000860 Walker B; other site 1046624000861 D-loop; other site 1046624000862 H-loop/switch region; other site 1046624000863 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1046624000864 BioY family; Region: BioY; pfam02632 1046624000865 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1046624000866 putative deacylase active site [active] 1046624000867 Predicted membrane protein [Function unknown]; Region: COG3859 1046624000868 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1046624000869 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1046624000870 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1046624000871 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1046624000872 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1046624000873 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1046624000874 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1046624000875 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1046624000876 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1046624000877 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1046624000878 Walker A/P-loop; other site 1046624000879 ATP binding site [chemical binding]; other site 1046624000880 Q-loop/lid; other site 1046624000881 ABC transporter signature motif; other site 1046624000882 Walker B; other site 1046624000883 D-loop; other site 1046624000884 H-loop/switch region; other site 1046624000885 NIL domain; Region: NIL; pfam09383 1046624000886 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1046624000887 hypothetical protein; Provisional; Region: PRK13661 1046624000888 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1046624000889 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1046624000890 Walker A/P-loop; other site 1046624000891 ATP binding site [chemical binding]; other site 1046624000892 Q-loop/lid; other site 1046624000893 ABC transporter signature motif; other site 1046624000894 Walker B; other site 1046624000895 D-loop; other site 1046624000896 H-loop/switch region; other site 1046624000897 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1046624000898 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1046624000899 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1046624000900 Walker A/P-loop; other site 1046624000901 ATP binding site [chemical binding]; other site 1046624000902 Q-loop/lid; other site 1046624000903 ABC transporter signature motif; other site 1046624000904 Walker B; other site 1046624000905 D-loop; other site 1046624000906 H-loop/switch region; other site 1046624000907 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1046624000908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624000909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624000910 non-specific DNA binding site [nucleotide binding]; other site 1046624000911 salt bridge; other site 1046624000912 sequence-specific DNA binding site [nucleotide binding]; other site 1046624000913 putative ferrichrome ABC transporter; may contain frameshift 1046624000914 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1046624000915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1046624000916 ABC-ATPase subunit interface; other site 1046624000917 dimer interface [polypeptide binding]; other site 1046624000918 putative PBP binding regions; other site 1046624000919 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1046624000920 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1046624000921 ABC-ATPase subunit interface; other site 1046624000922 dimer interface [polypeptide binding]; other site 1046624000923 putative PBP binding regions; other site 1046624000924 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1046624000925 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1046624000926 intersubunit interface [polypeptide binding]; other site 1046624000927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624000928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624000929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1046624000930 dimerization interface [polypeptide binding]; other site 1046624000931 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1046624000932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624000933 putative substrate translocation pore; other site 1046624000934 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624000935 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624000936 active site 1046624000937 catalytic tetrad [active] 1046624000938 Predicted transcriptional regulators [Transcription]; Region: COG1733 1046624000939 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1046624000940 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1046624000941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624000942 putative metal binding site [ion binding]; other site 1046624000943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624000944 catalytic core [active] 1046624000945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624000946 peroxiredoxin; Region: AhpC; TIGR03137 1046624000947 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1046624000948 dimer interface [polypeptide binding]; other site 1046624000949 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1046624000950 catalytic triad [active] 1046624000951 peroxidatic and resolving cysteines [active] 1046624000952 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1046624000953 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1046624000954 catalytic residue [active] 1046624000955 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1046624000956 catalytic residues [active] 1046624000957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624000958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624000959 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1046624000960 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1046624000961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1046624000962 recombination protein RecR; Reviewed; Region: recR; PRK00076 1046624000963 RecR protein; Region: RecR; pfam02132 1046624000964 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1046624000965 putative active site [active] 1046624000966 putative metal-binding site [ion binding]; other site 1046624000967 tetramer interface [polypeptide binding]; other site 1046624000968 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1046624000969 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1046624000970 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1046624000971 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1046624000972 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1046624000973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624000974 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1046624000975 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1046624000976 peptide binding site [polypeptide binding]; other site 1046624000977 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1046624000978 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1046624000979 peptide binding site [polypeptide binding]; other site 1046624000980 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1046624000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624000982 dimer interface [polypeptide binding]; other site 1046624000983 conserved gate region; other site 1046624000984 putative PBP binding loops; other site 1046624000985 ABC-ATPase subunit interface; other site 1046624000986 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1046624000987 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1046624000988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624000989 dimer interface [polypeptide binding]; other site 1046624000990 conserved gate region; other site 1046624000991 putative PBP binding loops; other site 1046624000992 ABC-ATPase subunit interface; other site 1046624000993 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1046624000994 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1046624000995 Walker A/P-loop; other site 1046624000996 ATP binding site [chemical binding]; other site 1046624000997 Q-loop/lid; other site 1046624000998 ABC transporter signature motif; other site 1046624000999 Walker B; other site 1046624001000 D-loop; other site 1046624001001 H-loop/switch region; other site 1046624001002 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1046624001003 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1046624001004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1046624001005 Walker A/P-loop; other site 1046624001006 ATP binding site [chemical binding]; other site 1046624001007 Q-loop/lid; other site 1046624001008 ABC transporter signature motif; other site 1046624001009 Walker B; other site 1046624001010 D-loop; other site 1046624001011 H-loop/switch region; other site 1046624001012 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1046624001013 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1046624001014 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1046624001015 G1 box; other site 1046624001016 putative GEF interaction site [polypeptide binding]; other site 1046624001017 GTP/Mg2+ binding site [chemical binding]; other site 1046624001018 Switch I region; other site 1046624001019 G2 box; other site 1046624001020 G3 box; other site 1046624001021 Switch II region; other site 1046624001022 G4 box; other site 1046624001023 G5 box; other site 1046624001024 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1046624001025 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1046624001026 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1046624001027 ATP binding site [chemical binding]; other site 1046624001028 Mg++ binding site [ion binding]; other site 1046624001029 motif III; other site 1046624001030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624001031 nucleotide binding region [chemical binding]; other site 1046624001032 ATP-binding site [chemical binding]; other site 1046624001033 GTPase Era; Reviewed; Region: era; PRK00089 1046624001034 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1046624001035 G1 box; other site 1046624001036 GTP/Mg2+ binding site [chemical binding]; other site 1046624001037 Switch I region; other site 1046624001038 G2 box; other site 1046624001039 Switch II region; other site 1046624001040 G3 box; other site 1046624001041 G4 box; other site 1046624001042 G5 box; other site 1046624001043 KH domain; Region: KH_2; pfam07650 1046624001044 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1046624001045 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1046624001046 dimer interface [polypeptide binding]; other site 1046624001047 active site 1046624001048 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1046624001049 Ligand Binding Site [chemical binding]; other site 1046624001050 Molecular Tunnel; other site 1046624001051 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1046624001052 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1046624001053 DNA binding site [nucleotide binding] 1046624001054 catalytic residue [active] 1046624001055 H2TH interface [polypeptide binding]; other site 1046624001056 putative catalytic residues [active] 1046624001057 turnover-facilitating residue; other site 1046624001058 intercalation triad [nucleotide binding]; other site 1046624001059 8OG recognition residue [nucleotide binding]; other site 1046624001060 putative reading head residues; other site 1046624001061 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1046624001062 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1046624001063 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1046624001064 hexamer interface [polypeptide binding]; other site 1046624001065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1046624001066 Walker A motif; other site 1046624001067 ATP binding site [chemical binding]; other site 1046624001068 Walker B motif; other site 1046624001069 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1046624001070 amino acid permease (yeast); Region: 2A0310; TIGR00913 1046624001071 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1046624001072 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1046624001073 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1046624001074 putative active site [active] 1046624001075 putative metal binding residues [ion binding]; other site 1046624001076 signature motif; other site 1046624001077 putative triphosphate binding site [ion binding]; other site 1046624001078 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1046624001079 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1046624001080 synthetase active site [active] 1046624001081 NTP binding site [chemical binding]; other site 1046624001082 metal binding site [ion binding]; metal-binding site 1046624001083 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1046624001084 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1046624001085 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1046624001086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1046624001087 active site 1046624001088 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1046624001089 active site 1046624001090 lysine transporter; Provisional; Region: PRK10836 1046624001091 Predicted flavoprotein [General function prediction only]; Region: COG0431 1046624001092 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1046624001093 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1046624001094 ApbE family; Region: ApbE; pfam02424 1046624001095 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1046624001096 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1046624001097 dimer interface [polypeptide binding]; other site 1046624001098 putative anticodon binding site; other site 1046624001099 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1046624001100 motif 1; other site 1046624001101 active site 1046624001102 motif 2; other site 1046624001103 motif 3; other site 1046624001104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624001105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624001106 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1046624001107 dimerization interface [polypeptide binding]; other site 1046624001108 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1046624001109 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1046624001110 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1046624001111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624001112 NAD binding site [chemical binding]; other site 1046624001113 dimer interface [polypeptide binding]; other site 1046624001114 substrate binding site [chemical binding]; other site 1046624001115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624001116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624001117 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1046624001118 dimerization interface [polypeptide binding]; other site 1046624001119 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1046624001120 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1046624001121 gating phenylalanine in ion channel; other site 1046624001122 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1046624001123 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1046624001124 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1046624001125 Ligand Binding Site [chemical binding]; other site 1046624001126 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1046624001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001128 putative substrate translocation pore; other site 1046624001129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001130 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1046624001131 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1046624001132 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1046624001133 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1046624001134 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1046624001135 active site 1046624001136 HIGH motif; other site 1046624001137 dimer interface [polypeptide binding]; other site 1046624001138 KMSKS motif; other site 1046624001139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624001140 RNA binding surface [nucleotide binding]; other site 1046624001141 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1046624001142 Transglycosylase; Region: Transgly; pfam00912 1046624001143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1046624001144 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1046624001145 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1046624001146 oligomer interface [polypeptide binding]; other site 1046624001147 active site 1046624001148 metal binding site [ion binding]; metal-binding site 1046624001149 Predicted small secreted protein [Function unknown]; Region: COG5584 1046624001150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1046624001151 catalytic residues [active] 1046624001152 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1046624001153 putative tRNA-binding site [nucleotide binding]; other site 1046624001154 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1046624001155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624001156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624001157 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1046624001158 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1046624001159 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1046624001160 dimer interface [polypeptide binding]; other site 1046624001161 ssDNA binding site [nucleotide binding]; other site 1046624001162 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624001163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1046624001164 oligomerisation interface [polypeptide binding]; other site 1046624001165 mobile loop; other site 1046624001166 roof hairpin; other site 1046624001167 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1046624001168 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1046624001169 ring oligomerisation interface [polypeptide binding]; other site 1046624001170 ATP/Mg binding site [chemical binding]; other site 1046624001171 stacking interactions; other site 1046624001172 hinge regions; other site 1046624001173 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1046624001174 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1046624001175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1046624001176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1046624001177 putative active site [active] 1046624001178 heme pocket [chemical binding]; other site 1046624001179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624001180 dimer interface [polypeptide binding]; other site 1046624001181 phosphorylation site [posttranslational modification] 1046624001182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624001183 ATP binding site [chemical binding]; other site 1046624001184 Mg2+ binding site [ion binding]; other site 1046624001185 G-X-G motif; other site 1046624001186 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624001187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624001188 active site 1046624001189 phosphorylation site [posttranslational modification] 1046624001190 intermolecular recognition site; other site 1046624001191 dimerization interface [polypeptide binding]; other site 1046624001192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624001193 DNA binding site [nucleotide binding] 1046624001194 thymidylate kinase; Validated; Region: tmk; PRK00698 1046624001195 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1046624001196 TMP-binding site; other site 1046624001197 ATP-binding site [chemical binding]; other site 1046624001198 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1046624001199 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1046624001200 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1046624001201 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1046624001202 Predicted methyltransferases [General function prediction only]; Region: COG0313 1046624001203 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1046624001204 putative SAM binding site [chemical binding]; other site 1046624001205 putative homodimer interface [polypeptide binding]; other site 1046624001206 mevalonate kinase; Region: mevalon_kin; TIGR00549 1046624001207 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1046624001208 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1046624001209 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1046624001210 diphosphomevalonate decarboxylase; Region: PLN02407 1046624001211 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1046624001212 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1046624001213 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1046624001214 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1046624001215 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1046624001216 homotetramer interface [polypeptide binding]; other site 1046624001217 FMN binding site [chemical binding]; other site 1046624001218 homodimer contacts [polypeptide binding]; other site 1046624001219 putative active site [active] 1046624001220 putative substrate binding site [chemical binding]; other site 1046624001221 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1046624001222 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1046624001223 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1046624001224 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1046624001225 Carbon starvation protein CstA; Region: CstA; pfam02554 1046624001226 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1046624001227 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1046624001228 Predicted transcriptional regulator [Transcription]; Region: COG2378 1046624001229 HTH domain; Region: HTH_11; pfam08279 1046624001230 WYL domain; Region: WYL; pfam13280 1046624001231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1046624001232 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1046624001233 ATP binding site [chemical binding]; other site 1046624001234 Mg++ binding site [ion binding]; other site 1046624001235 motif III; other site 1046624001236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624001237 nucleotide binding region [chemical binding]; other site 1046624001238 ATP-binding site [chemical binding]; other site 1046624001239 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1046624001240 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1046624001241 putative active site [active] 1046624001242 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624001243 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624001244 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624001245 putative active site [active] 1046624001246 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1046624001247 active site 1046624001248 P-loop; other site 1046624001249 phosphorylation site [posttranslational modification] 1046624001250 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1046624001251 active site 1046624001252 methionine cluster; other site 1046624001253 phosphorylation site [posttranslational modification] 1046624001254 metal binding site [ion binding]; metal-binding site 1046624001255 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624001256 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624001257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624001258 putative active site [active] 1046624001259 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1046624001260 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1046624001261 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1046624001262 beta-galactosidase; Region: BGL; TIGR03356 1046624001263 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1046624001264 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1046624001265 nucleotide binding pocket [chemical binding]; other site 1046624001266 K-X-D-G motif; other site 1046624001267 catalytic site [active] 1046624001268 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1046624001269 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1046624001270 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1046624001271 Dimer interface [polypeptide binding]; other site 1046624001272 BRCT sequence motif; other site 1046624001273 putative lipid kinase; Reviewed; Region: PRK13055 1046624001274 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1046624001275 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1046624001276 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1046624001277 Walker A/P-loop; other site 1046624001278 ATP binding site [chemical binding]; other site 1046624001279 Q-loop/lid; other site 1046624001280 ABC transporter signature motif; other site 1046624001281 Walker B; other site 1046624001282 D-loop; other site 1046624001283 H-loop/switch region; other site 1046624001284 TOBE domain; Region: TOBE_2; pfam08402 1046624001285 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1046624001286 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1046624001287 dimer interface [polypeptide binding]; other site 1046624001288 PYR/PP interface [polypeptide binding]; other site 1046624001289 TPP binding site [chemical binding]; other site 1046624001290 substrate binding site [chemical binding]; other site 1046624001291 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1046624001292 Domain of unknown function; Region: EKR; smart00890 1046624001293 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1046624001294 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1046624001295 TPP-binding site [chemical binding]; other site 1046624001296 dimer interface [polypeptide binding]; other site 1046624001297 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1046624001298 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1046624001299 YbbR-like protein; Region: YbbR; pfam07949 1046624001300 YbbR-like protein; Region: YbbR; pfam07949 1046624001301 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1046624001302 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1046624001303 active site 1046624001304 substrate binding site [chemical binding]; other site 1046624001305 metal binding site [ion binding]; metal-binding site 1046624001306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1046624001307 DNA-binding site [nucleotide binding]; DNA binding site 1046624001308 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1046624001309 UTRA domain; Region: UTRA; pfam07702 1046624001310 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1046624001311 HPr interaction site; other site 1046624001312 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1046624001313 active site 1046624001314 phosphorylation site [posttranslational modification] 1046624001315 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1046624001316 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1046624001317 active site turn [active] 1046624001318 phosphorylation site [posttranslational modification] 1046624001319 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1046624001320 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1046624001321 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1046624001322 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1046624001323 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1046624001324 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1046624001325 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624001326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624001327 motif II; other site 1046624001328 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1046624001329 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1046624001330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1046624001331 nucleophilic elbow; other site 1046624001332 catalytic triad; other site 1046624001333 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1046624001334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1046624001335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624001336 Coenzyme A binding pocket [chemical binding]; other site 1046624001337 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1046624001338 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1046624001339 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1046624001340 dimerization interface 3.5A [polypeptide binding]; other site 1046624001341 active site 1046624001342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1046624001343 dimer interface [polypeptide binding]; other site 1046624001344 substrate binding site [chemical binding]; other site 1046624001345 ATP binding site [chemical binding]; other site 1046624001346 Predicted membrane protein [Function unknown]; Region: COG4720 1046624001347 hypothetical protein; Provisional; Region: PRK13690 1046624001348 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1046624001349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1046624001350 catalytic residue [active] 1046624001351 CTP synthetase; Validated; Region: pyrG; PRK05380 1046624001352 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1046624001353 Catalytic site [active] 1046624001354 active site 1046624001355 UTP binding site [chemical binding]; other site 1046624001356 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1046624001357 active site 1046624001358 putative oxyanion hole; other site 1046624001359 catalytic triad [active] 1046624001360 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1046624001361 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1046624001362 NAD(P) binding site [chemical binding]; other site 1046624001363 LDH/MDH dimer interface [polypeptide binding]; other site 1046624001364 substrate binding site [chemical binding]; other site 1046624001365 Predicted membrane protein [Function unknown]; Region: COG4420 1046624001366 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1046624001367 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1046624001368 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1046624001369 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1046624001370 Substrate-binding site [chemical binding]; other site 1046624001371 Substrate specificity [chemical binding]; other site 1046624001372 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1046624001373 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1046624001374 active site 1046624001375 PHP Thumb interface [polypeptide binding]; other site 1046624001376 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1046624001377 generic binding surface II; other site 1046624001378 generic binding surface I; other site 1046624001379 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1046624001380 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1046624001381 EDD domain protein, DegV family; Region: DegV; TIGR00762 1046624001382 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1046624001383 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1046624001384 active site 1046624001385 catalytic triad [active] 1046624001386 oxyanion hole [active] 1046624001387 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1046624001388 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1046624001389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 1046624001390 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1046624001391 IHF dimer interface [polypeptide binding]; other site 1046624001392 IHF - DNA interface [nucleotide binding]; other site 1046624001393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1046624001394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624001395 Coenzyme A binding pocket [chemical binding]; other site 1046624001396 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1046624001397 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1046624001398 DNA binding site [nucleotide binding] 1046624001399 active site 1046624001400 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1046624001401 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1046624001402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1046624001403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1046624001404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1046624001405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1046624001406 Walker A/P-loop; other site 1046624001407 ATP binding site [chemical binding]; other site 1046624001408 Q-loop/lid; other site 1046624001409 ABC transporter signature motif; other site 1046624001410 Walker B; other site 1046624001411 D-loop; other site 1046624001412 H-loop/switch region; other site 1046624001413 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1046624001414 LytTr DNA-binding domain; Region: LytTR; pfam04397 1046624001415 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1046624001416 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1046624001417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1046624001418 catalytic residue [active] 1046624001419 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1046624001420 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1046624001421 NlpC/P60 family; Region: NLPC_P60; cl17555 1046624001422 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1046624001423 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1046624001424 peptide binding site [polypeptide binding]; other site 1046624001425 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1046624001426 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1046624001427 dimer interface [polypeptide binding]; other site 1046624001428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624001429 catalytic residue [active] 1046624001430 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1046624001431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624001432 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624001433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624001434 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1046624001435 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1046624001436 Transglycosylase; Region: Transgly; pfam00912 1046624001437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1046624001438 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1046624001439 hypothetical protein; Provisional; Region: PRK13660 1046624001440 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1046624001441 ArsC family; Region: ArsC; pfam03960 1046624001442 putative catalytic residues [active] 1046624001443 thiol/disulfide switch; other site 1046624001444 hypothetical protein; Provisional; Region: PRK04387 1046624001445 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1046624001446 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1046624001447 active site 1046624001448 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1046624001449 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1046624001450 hinge; other site 1046624001451 active site 1046624001452 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1046624001453 trigger factor; Provisional; Region: tig; PRK01490 1046624001454 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1046624001455 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1046624001456 DNA primase, catalytic core; Region: dnaG; TIGR01391 1046624001457 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1046624001458 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1046624001459 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1046624001460 active site 1046624001461 metal binding site [ion binding]; metal-binding site 1046624001462 interdomain interaction site; other site 1046624001463 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1046624001464 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1046624001465 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1046624001466 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1046624001467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1046624001468 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1046624001469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1046624001470 DNA binding residues [nucleotide binding] 1046624001471 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624001472 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624001473 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624001474 putative active site [active] 1046624001475 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1046624001476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001477 putative substrate translocation pore; other site 1046624001478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624001480 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1046624001481 Walker A motif; other site 1046624001482 ATP binding site [chemical binding]; other site 1046624001483 Walker B motif; other site 1046624001484 arginine finger; other site 1046624001485 UvrB/uvrC motif; Region: UVR; pfam02151 1046624001486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624001487 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1046624001488 Walker A motif; other site 1046624001489 ATP binding site [chemical binding]; other site 1046624001490 Walker B motif; other site 1046624001491 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1046624001492 Predicted transcriptional regulator [Transcription]; Region: COG1959 1046624001493 Transcriptional regulator; Region: Rrf2; pfam02082 1046624001494 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1046624001495 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1046624001496 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1046624001497 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1046624001498 active site 1046624001499 catalytic residues [active] 1046624001500 metal binding site [ion binding]; metal-binding site 1046624001501 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1046624001502 putative active site [active] 1046624001503 Ap4A binding site [chemical binding]; other site 1046624001504 nudix motif; other site 1046624001505 putative metal binding site [ion binding]; other site 1046624001506 excinuclease ABC subunit B; Provisional; Region: PRK05298 1046624001507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624001508 ATP binding site [chemical binding]; other site 1046624001509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624001510 nucleotide binding region [chemical binding]; other site 1046624001511 ATP-binding site [chemical binding]; other site 1046624001512 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1046624001513 UvrB/uvrC motif; Region: UVR; pfam02151 1046624001514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1046624001515 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1046624001516 substrate binding pocket [chemical binding]; other site 1046624001517 membrane-bound complex binding site; other site 1046624001518 hinge residues; other site 1046624001519 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1046624001520 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1046624001521 metal binding site [ion binding]; metal-binding site 1046624001522 dimer interface [polypeptide binding]; other site 1046624001523 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1046624001524 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1046624001525 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1046624001526 NAD binding site [chemical binding]; other site 1046624001527 homotetramer interface [polypeptide binding]; other site 1046624001528 homodimer interface [polypeptide binding]; other site 1046624001529 substrate binding site [chemical binding]; other site 1046624001530 active site 1046624001531 OxaA-like protein precursor; Provisional; Region: PRK02463 1046624001532 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1046624001533 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1046624001534 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1046624001535 Predicted membrane protein [Function unknown]; Region: COG4684 1046624001536 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1046624001537 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 1046624001538 Flavoprotein; Region: Flavoprotein; pfam02441 1046624001539 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1046624001540 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1046624001541 active site 1 [active] 1046624001542 dimer interface [polypeptide binding]; other site 1046624001543 hexamer interface [polypeptide binding]; other site 1046624001544 active site 2 [active] 1046624001545 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1046624001546 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624001547 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1046624001548 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1046624001549 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1046624001550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624001551 Coenzyme A binding pocket [chemical binding]; other site 1046624001552 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1046624001553 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1046624001554 putative active site [active] 1046624001555 hypothetical protein; Provisional; Region: PRK06760; cl11698 1046624001556 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1046624001557 Predicted membrane protein [Function unknown]; Region: COG4852 1046624001558 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1046624001559 DAK2 domain; Region: Dak2; pfam02734 1046624001560 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1046624001561 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1046624001562 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1046624001563 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1046624001564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624001565 active site 1046624001566 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1046624001567 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1046624001568 DNA polymerase IV; Reviewed; Region: PRK03103 1046624001569 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1046624001570 active site 1046624001571 DNA binding site [nucleotide binding] 1046624001572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624001573 Coenzyme A binding pocket [chemical binding]; other site 1046624001574 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624001575 MarR family; Region: MarR; pfam01047 1046624001576 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1046624001577 thymidine kinase; Provisional; Region: PRK04296 1046624001578 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1046624001579 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1046624001580 RF-1 domain; Region: RF-1; pfam00472 1046624001581 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1046624001582 dimer interface [polypeptide binding]; other site 1046624001583 FMN binding site [chemical binding]; other site 1046624001584 NADPH bind site [chemical binding]; other site 1046624001585 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1046624001586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624001587 S-adenosylmethionine binding site [chemical binding]; other site 1046624001588 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1046624001589 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1046624001590 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1046624001591 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1046624001592 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1046624001593 dimer interface [polypeptide binding]; other site 1046624001594 active site 1046624001595 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1046624001596 folate binding site [chemical binding]; other site 1046624001597 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1046624001598 Lysozyme-like; Region: Lysozyme_like; pfam13702 1046624001599 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1046624001600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1046624001601 catalytic residue [active] 1046624001602 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1046624001603 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1046624001604 putative ligand binding site [chemical binding]; other site 1046624001605 putative NAD binding site [chemical binding]; other site 1046624001606 putative catalytic site [active] 1046624001607 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1046624001608 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1046624001609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624001610 motif II; other site 1046624001611 Acylphosphatase; Region: Acylphosphatase; cl00551 1046624001612 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1046624001613 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1046624001614 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1046624001615 flavodoxin; Validated; Region: PRK07308 1046624001616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624001618 putative substrate translocation pore; other site 1046624001619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624001620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624001621 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1046624001622 active site 1046624001623 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1046624001624 Predicted membrane protein [Function unknown]; Region: COG2246 1046624001625 GtrA-like protein; Region: GtrA; pfam04138 1046624001626 Tim44-like domain; Region: Tim44; cl09208 1046624001627 Predicted membrane protein [Function unknown]; Region: COG3326 1046624001628 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 1046624001629 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1046624001630 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1046624001631 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1046624001632 Hpr binding site; other site 1046624001633 active site 1046624001634 homohexamer subunit interaction site [polypeptide binding]; other site 1046624001635 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1046624001636 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1046624001637 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1046624001638 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1046624001639 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1046624001640 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1046624001641 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1046624001642 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1046624001643 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1046624001644 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1046624001645 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1046624001646 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1046624001647 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1046624001648 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1046624001649 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1046624001650 ribonuclease Z; Region: RNase_Z; TIGR02651 1046624001651 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1046624001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624001653 NAD(P) binding site [chemical binding]; other site 1046624001654 active site 1046624001655 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1046624001656 DHH family; Region: DHH; pfam01368 1046624001657 DHHA1 domain; Region: DHHA1; pfam02272 1046624001658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1046624001659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624001660 active site 1046624001661 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1046624001662 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1046624001663 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1046624001664 dimerization interface [polypeptide binding]; other site 1046624001665 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1046624001666 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1046624001667 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1046624001668 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1046624001669 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1046624001670 Clp amino terminal domain; Region: Clp_N; pfam02861 1046624001671 Clp amino terminal domain; Region: Clp_N; pfam02861 1046624001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624001673 Walker A motif; other site 1046624001674 ATP binding site [chemical binding]; other site 1046624001675 Walker B motif; other site 1046624001676 arginine finger; other site 1046624001677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624001678 Walker A motif; other site 1046624001679 ATP binding site [chemical binding]; other site 1046624001680 Walker B motif; other site 1046624001681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1046624001682 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1046624001683 30S subunit binding site; other site 1046624001684 enolase; Provisional; Region: eno; PRK00077 1046624001685 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1046624001686 dimer interface [polypeptide binding]; other site 1046624001687 metal binding site [ion binding]; metal-binding site 1046624001688 substrate binding pocket [chemical binding]; other site 1046624001689 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624001690 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624001691 Walker A/P-loop; other site 1046624001692 ATP binding site [chemical binding]; other site 1046624001693 Q-loop/lid; other site 1046624001694 ABC transporter signature motif; other site 1046624001695 Walker B; other site 1046624001696 D-loop; other site 1046624001697 H-loop/switch region; other site 1046624001698 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1046624001699 FtsX-like permease family; Region: FtsX; pfam02687 1046624001700 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1046624001701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624001702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624001703 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1046624001704 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1046624001705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1046624001706 acyl-activating enzyme (AAE) consensus motif; other site 1046624001707 acyl-activating enzyme (AAE) consensus motif; other site 1046624001708 AMP binding site [chemical binding]; other site 1046624001709 active site 1046624001710 CoA binding site [chemical binding]; other site 1046624001711 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1046624001712 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1046624001713 Cl binding site [ion binding]; other site 1046624001714 oligomer interface [polypeptide binding]; other site 1046624001715 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1046624001716 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1046624001717 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1046624001718 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1046624001719 CoA-binding site [chemical binding]; other site 1046624001720 ATP-binding [chemical binding]; other site 1046624001721 drug efflux system protein MdtG; Provisional; Region: PRK09874 1046624001722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001723 putative substrate translocation pore; other site 1046624001724 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1046624001725 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1046624001726 pyruvate carboxylase; Reviewed; Region: PRK12999 1046624001727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1046624001728 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1046624001729 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1046624001730 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1046624001731 active site 1046624001732 catalytic residues [active] 1046624001733 metal binding site [ion binding]; metal-binding site 1046624001734 homodimer binding site [polypeptide binding]; other site 1046624001735 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1046624001736 carboxyltransferase (CT) interaction site; other site 1046624001737 biotinylation site [posttranslational modification]; other site 1046624001738 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 1046624001739 dimer interface [polypeptide binding]; other site 1046624001740 Citrate synthase; Region: Citrate_synt; pfam00285 1046624001741 active site 1046624001742 citrylCoA binding site [chemical binding]; other site 1046624001743 oxalacetate/citrate binding site [chemical binding]; other site 1046624001744 coenzyme A binding site [chemical binding]; other site 1046624001745 catalytic triad [active] 1046624001746 aconitate hydratase; Validated; Region: PRK09277 1046624001747 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1046624001748 substrate binding site [chemical binding]; other site 1046624001749 ligand binding site [chemical binding]; other site 1046624001750 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1046624001751 substrate binding site [chemical binding]; other site 1046624001752 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 1046624001753 isocitrate dehydrogenase; Validated; Region: PRK07362 1046624001754 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1046624001755 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1046624001756 oligomer interface [polypeptide binding]; other site 1046624001757 active site residues [active] 1046624001758 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1046624001759 ArsC family; Region: ArsC; pfam03960 1046624001760 putative catalytic residues [active] 1046624001761 thiol/disulfide switch; other site 1046624001762 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1046624001763 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1046624001764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624001765 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1046624001766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624001767 motif II; other site 1046624001768 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1046624001769 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1046624001770 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1046624001771 N-glycosyltransferase; Provisional; Region: PRK11204 1046624001772 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1046624001773 DXD motif; other site 1046624001774 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 1046624001775 putative active site [active] 1046624001776 putative metal binding site [ion binding]; other site 1046624001777 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1046624001778 Collagen binding domain; Region: Collagen_bind; pfam05737 1046624001779 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1046624001780 domain interaction interfaces [polypeptide binding]; other site 1046624001781 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1046624001782 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1046624001783 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1046624001784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1046624001785 HTH-like domain; Region: HTH_21; pfam13276 1046624001786 Integrase core domain; Region: rve; pfam00665 1046624001787 Integrase core domain; Region: rve_3; pfam13683 1046624001788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1046624001789 Transposase; Region: HTH_Tnp_1; pfam01527 1046624001790 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 1046624001791 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1046624001792 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1046624001793 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1046624001794 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624001795 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1046624001796 Walker A/P-loop; other site 1046624001797 ATP binding site [chemical binding]; other site 1046624001798 Q-loop/lid; other site 1046624001799 ABC transporter signature motif; other site 1046624001800 Walker B; other site 1046624001801 D-loop; other site 1046624001802 H-loop/switch region; other site 1046624001803 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1046624001804 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1046624001805 active site 1046624001806 zinc binding site [ion binding]; other site 1046624001807 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1046624001808 active site 1046624001809 catalytic triad [active] 1046624001810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624001812 active site 1046624001813 phosphorylation site [posttranslational modification] 1046624001814 intermolecular recognition site; other site 1046624001815 dimerization interface [polypeptide binding]; other site 1046624001816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624001817 DNA binding site [nucleotide binding] 1046624001818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624001819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624001820 dimer interface [polypeptide binding]; other site 1046624001821 phosphorylation site [posttranslational modification] 1046624001822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624001823 ATP binding site [chemical binding]; other site 1046624001824 Mg2+ binding site [ion binding]; other site 1046624001825 G-X-G motif; other site 1046624001826 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1046624001827 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1046624001828 Walker A/P-loop; other site 1046624001829 ATP binding site [chemical binding]; other site 1046624001830 Q-loop/lid; other site 1046624001831 ABC transporter signature motif; other site 1046624001832 Walker B; other site 1046624001833 D-loop; other site 1046624001834 H-loop/switch region; other site 1046624001835 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1046624001836 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1046624001837 Integrase core domain; Region: rve; pfam00665 1046624001838 Integrase core domain; Region: rve_3; pfam13683 1046624001839 HTH-like domain; Region: HTH_21; pfam13276 1046624001840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1046624001841 Transposase; Region: HTH_Tnp_1; pfam01527 1046624001842 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624001843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624001844 DNA binding site [nucleotide binding] 1046624001845 domain linker motif; other site 1046624001846 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1046624001847 dimerization interface [polypeptide binding]; other site 1046624001848 ligand binding site [chemical binding]; other site 1046624001849 sodium binding site [ion binding]; other site 1046624001850 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1046624001851 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1046624001852 substrate binding [chemical binding]; other site 1046624001853 active site 1046624001854 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1046624001855 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1046624001856 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1046624001857 active site turn [active] 1046624001858 phosphorylation site [posttranslational modification] 1046624001859 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1046624001860 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1046624001861 HPr interaction site; other site 1046624001862 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1046624001863 active site 1046624001864 phosphorylation site [posttranslational modification] 1046624001865 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1046624001866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624001867 nucleotide binding site [chemical binding]; other site 1046624001868 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1046624001869 DNA-binding site [nucleotide binding]; DNA binding site 1046624001870 RNA-binding motif; other site 1046624001871 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1046624001872 DNA-binding site [nucleotide binding]; DNA binding site 1046624001873 RNA-binding motif; other site 1046624001874 Predicted membrane protein [Function unknown]; Region: COG2261 1046624001875 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1046624001876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1046624001877 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1046624001878 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1046624001879 oligomer interface [polypeptide binding]; other site 1046624001880 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 1046624001881 putative active site [active] 1046624001882 putative ligand binding site [chemical binding]; other site 1046624001883 putative NAD(P) binding site [chemical binding]; other site 1046624001884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624001885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624001886 non-specific DNA binding site [nucleotide binding]; other site 1046624001887 salt bridge; other site 1046624001888 sequence-specific DNA binding site [nucleotide binding]; other site 1046624001889 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1046624001890 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1046624001891 active site 1046624001892 homodimer interface [polypeptide binding]; other site 1046624001893 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1046624001894 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1046624001895 DXD motif; other site 1046624001896 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1046624001897 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1046624001898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624001899 Walker A/P-loop; other site 1046624001900 ATP binding site [chemical binding]; other site 1046624001901 Q-loop/lid; other site 1046624001902 ABC transporter signature motif; other site 1046624001903 Walker B; other site 1046624001904 D-loop; other site 1046624001905 H-loop/switch region; other site 1046624001906 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1046624001907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624001908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624001909 non-specific DNA binding site [nucleotide binding]; other site 1046624001910 salt bridge; other site 1046624001911 sequence-specific DNA binding site [nucleotide binding]; other site 1046624001912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624001913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624001914 non-specific DNA binding site [nucleotide binding]; other site 1046624001915 salt bridge; other site 1046624001916 sequence-specific DNA binding site [nucleotide binding]; other site 1046624001917 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1046624001918 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1046624001919 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1046624001920 Replication initiation factor; Region: Rep_trans; pfam02486 1046624001921 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1046624001922 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1046624001923 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1046624001924 AAA-like domain; Region: AAA_10; pfam12846 1046624001925 Domain of unknown function DUF87; Region: DUF87; pfam01935 1046624001926 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1046624001927 CHAP domain; Region: CHAP; pfam05257 1046624001928 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1046624001929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1046624001930 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1046624001931 Int/Topo IB signature motif; other site 1046624001932 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1046624001933 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1046624001934 active site 1046624001935 topology modulation protein; Reviewed; Region: PRK08118 1046624001936 AAA domain; Region: AAA_17; pfam13207 1046624001937 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1046624001938 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1046624001939 putative active site [active] 1046624001940 putative metal binding site [ion binding]; other site 1046624001941 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1046624001942 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1046624001943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624001944 S-adenosylmethionine binding site [chemical binding]; other site 1046624001945 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1046624001946 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1046624001947 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1046624001948 active site 1046624001949 elongation factor P; Validated; Region: PRK00529 1046624001950 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1046624001951 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1046624001952 RNA binding site [nucleotide binding]; other site 1046624001953 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1046624001954 RNA binding site [nucleotide binding]; other site 1046624001955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1046624001956 Transcription termination factor [Transcription]; Region: NusB; COG0781 1046624001957 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1046624001958 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1046624001959 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1046624001960 ligand binding site; other site 1046624001961 oligomer interface; other site 1046624001962 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1046624001963 dimer interface [polypeptide binding]; other site 1046624001964 N-terminal domain interface [polypeptide binding]; other site 1046624001965 sulfate 1 binding site; other site 1046624001966 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1046624001967 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1046624001968 ligand binding site; other site 1046624001969 oligomer interface; other site 1046624001970 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1046624001971 dimer interface [polypeptide binding]; other site 1046624001972 N-terminal domain interface [polypeptide binding]; other site 1046624001973 sulfate 1 binding site; other site 1046624001974 glycogen synthase; Provisional; Region: glgA; PRK00654 1046624001975 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1046624001976 ADP-binding pocket [chemical binding]; other site 1046624001977 homodimer interface [polypeptide binding]; other site 1046624001978 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1046624001979 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1046624001980 active site pocket [active] 1046624001981 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1046624001982 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1046624001983 active site 1046624001984 homodimer interface [polypeptide binding]; other site 1046624001985 catalytic site [active] 1046624001986 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1046624001987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624001988 putative substrate translocation pore; other site 1046624001989 POT family; Region: PTR2; pfam00854 1046624001990 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1046624001991 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1046624001992 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1046624001993 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1046624001994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624001995 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1046624001996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624001997 Walker A/P-loop; other site 1046624001998 ATP binding site [chemical binding]; other site 1046624001999 Q-loop/lid; other site 1046624002000 ABC transporter signature motif; other site 1046624002001 Walker B; other site 1046624002002 D-loop; other site 1046624002003 H-loop/switch region; other site 1046624002004 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1046624002005 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1046624002006 Walker A/P-loop; other site 1046624002007 ATP binding site [chemical binding]; other site 1046624002008 Q-loop/lid; other site 1046624002009 ABC transporter signature motif; other site 1046624002010 Walker B; other site 1046624002011 D-loop; other site 1046624002012 H-loop/switch region; other site 1046624002013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624002014 putative Zn2+ binding site [ion binding]; other site 1046624002015 putative DNA binding site [nucleotide binding]; other site 1046624002016 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1046624002017 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1046624002018 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1046624002019 active site 1046624002020 catalytic triad [active] 1046624002021 oxyanion hole [active] 1046624002022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624002023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624002024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624002025 Walker A/P-loop; other site 1046624002026 ATP binding site [chemical binding]; other site 1046624002027 Q-loop/lid; other site 1046624002028 ABC transporter signature motif; other site 1046624002029 Walker B; other site 1046624002030 D-loop; other site 1046624002031 H-loop/switch region; other site 1046624002032 Predicted integral membrane protein [Function unknown]; Region: COG3548 1046624002033 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1046624002034 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1046624002035 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624002036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624002037 Walker A/P-loop; other site 1046624002038 ATP binding site [chemical binding]; other site 1046624002039 Q-loop/lid; other site 1046624002040 ABC transporter signature motif; other site 1046624002041 Walker B; other site 1046624002042 D-loop; other site 1046624002043 H-loop/switch region; other site 1046624002044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1046624002045 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1046624002046 FtsX-like permease family; Region: FtsX; pfam02687 1046624002047 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1046624002048 Predicted membrane protein [Function unknown]; Region: COG3619 1046624002049 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1046624002050 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1046624002051 putative NAD(P) binding site [chemical binding]; other site 1046624002052 dimer interface [polypeptide binding]; other site 1046624002053 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1046624002054 substrate binding site [chemical binding]; other site 1046624002055 THF binding site; other site 1046624002056 zinc-binding site [ion binding]; other site 1046624002057 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1046624002058 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1046624002059 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1046624002060 active site 1046624002061 metal binding site [ion binding]; metal-binding site 1046624002062 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1046624002063 nucleoside/Zn binding site; other site 1046624002064 dimer interface [polypeptide binding]; other site 1046624002065 catalytic motif [active] 1046624002066 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1046624002067 CoenzymeA binding site [chemical binding]; other site 1046624002068 subunit interaction site [polypeptide binding]; other site 1046624002069 PHB binding site; other site 1046624002070 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1046624002071 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1046624002072 active site 1046624002073 octamer interface [polypeptide binding]; other site 1046624002074 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1046624002075 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1046624002076 acyl-activating enzyme (AAE) consensus motif; other site 1046624002077 putative AMP binding site [chemical binding]; other site 1046624002078 putative active site [active] 1046624002079 putative CoA binding site [chemical binding]; other site 1046624002080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1046624002081 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1046624002082 substrate binding site [chemical binding]; other site 1046624002083 oxyanion hole (OAH) forming residues; other site 1046624002084 trimer interface [polypeptide binding]; other site 1046624002085 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1046624002086 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1046624002087 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1046624002088 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1046624002089 dimer interface [polypeptide binding]; other site 1046624002090 tetramer interface [polypeptide binding]; other site 1046624002091 PYR/PP interface [polypeptide binding]; other site 1046624002092 TPP binding site [chemical binding]; other site 1046624002093 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1046624002094 TPP-binding site; other site 1046624002095 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1046624002096 isochorismate synthases; Region: isochor_syn; TIGR00543 1046624002097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1046624002098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1046624002099 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1046624002100 DRTGG domain; Region: DRTGG; pfam07085 1046624002101 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1046624002102 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1046624002103 DHH family; Region: DHH; pfam01368 1046624002104 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1046624002105 active site 1046624002106 homotetramer interface [polypeptide binding]; other site 1046624002107 homodimer interface [polypeptide binding]; other site 1046624002108 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1046624002109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002110 active site 1046624002111 motif I; other site 1046624002112 motif II; other site 1046624002113 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624002114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 1046624002115 metal binding site [ion binding]; metal-binding site 1046624002116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1046624002117 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1046624002118 aspartate kinase; Reviewed; Region: PRK09034 1046624002119 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1046624002120 nucleotide binding site [chemical binding]; other site 1046624002121 substrate binding site [chemical binding]; other site 1046624002122 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1046624002123 allosteric regulatory residue; other site 1046624002124 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1046624002125 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1046624002126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002127 motif II; other site 1046624002128 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1046624002129 DHH family; Region: DHH; pfam01368 1046624002130 DHHA1 domain; Region: DHHA1; pfam02272 1046624002131 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1046624002132 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1046624002133 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1046624002134 replicative DNA helicase; Provisional; Region: PRK05748 1046624002135 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1046624002136 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1046624002137 Walker A motif; other site 1046624002138 ATP binding site [chemical binding]; other site 1046624002139 Walker B motif; other site 1046624002140 DNA binding loops [nucleotide binding] 1046624002141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1046624002142 Phosphotransferase enzyme family; Region: APH; pfam01636 1046624002143 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1046624002144 active site 1046624002145 ATP binding site [chemical binding]; other site 1046624002146 substrate binding site [chemical binding]; other site 1046624002147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624002148 S-adenosylmethionine binding site [chemical binding]; other site 1046624002149 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1046624002150 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 1046624002151 ATP cone domain; Region: ATP-cone; pfam03477 1046624002152 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1046624002153 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1046624002154 primosomal protein DnaI; Reviewed; Region: PRK08939 1046624002155 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1046624002156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624002157 Walker A motif; other site 1046624002158 ATP binding site [chemical binding]; other site 1046624002159 Walker B motif; other site 1046624002160 arginine finger; other site 1046624002161 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1046624002162 dimer interface [polypeptide binding]; other site 1046624002163 FMN binding site [chemical binding]; other site 1046624002164 NADPH bind site [chemical binding]; other site 1046624002165 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1046624002166 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1046624002167 GTP-binding protein Der; Reviewed; Region: PRK00093 1046624002168 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1046624002169 G1 box; other site 1046624002170 GTP/Mg2+ binding site [chemical binding]; other site 1046624002171 Switch I region; other site 1046624002172 G2 box; other site 1046624002173 Switch II region; other site 1046624002174 G3 box; other site 1046624002175 G4 box; other site 1046624002176 G5 box; other site 1046624002177 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1046624002178 G1 box; other site 1046624002179 GTP/Mg2+ binding site [chemical binding]; other site 1046624002180 Switch I region; other site 1046624002181 G2 box; other site 1046624002182 G3 box; other site 1046624002183 Switch II region; other site 1046624002184 G4 box; other site 1046624002185 G5 box; other site 1046624002186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624002187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624002188 non-specific DNA binding site [nucleotide binding]; other site 1046624002189 salt bridge; other site 1046624002190 sequence-specific DNA binding site [nucleotide binding]; other site 1046624002191 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624002192 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1046624002193 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1046624002194 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1046624002195 active site 1046624002196 catalytic site [active] 1046624002197 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 1046624002198 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1046624002199 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1046624002200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 1046624002201 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1046624002202 putative oligomer interface [polypeptide binding]; other site 1046624002203 putative RNA binding site [nucleotide binding]; other site 1046624002204 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1046624002205 NusA N-terminal domain; Region: NusA_N; pfam08529 1046624002206 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1046624002207 RNA binding site [nucleotide binding]; other site 1046624002208 homodimer interface [polypeptide binding]; other site 1046624002209 NusA-like KH domain; Region: KH_5; pfam13184 1046624002210 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1046624002211 G-X-X-G motif; other site 1046624002212 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1046624002213 putative RNA binding cleft [nucleotide binding]; other site 1046624002214 hypothetical protein; Provisional; Region: PRK07283 1046624002215 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1046624002216 translation initiation factor IF-2; Region: IF-2; TIGR00487 1046624002217 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1046624002218 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1046624002219 G1 box; other site 1046624002220 putative GEF interaction site [polypeptide binding]; other site 1046624002221 GTP/Mg2+ binding site [chemical binding]; other site 1046624002222 Switch I region; other site 1046624002223 G2 box; other site 1046624002224 G3 box; other site 1046624002225 Switch II region; other site 1046624002226 G4 box; other site 1046624002227 G5 box; other site 1046624002228 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1046624002229 Translation-initiation factor 2; Region: IF-2; pfam11987 1046624002230 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1046624002231 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1046624002232 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1046624002233 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1046624002234 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624002235 MarR family; Region: MarR; pfam01047 1046624002236 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1046624002237 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1046624002238 dimer interface [polypeptide binding]; other site 1046624002239 active site 1046624002240 CoA binding pocket [chemical binding]; other site 1046624002241 acyl carrier protein; Provisional; Region: acpP; PRK00982 1046624002242 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1046624002243 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1046624002244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1046624002245 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1046624002246 NAD(P) binding site [chemical binding]; other site 1046624002247 homotetramer interface [polypeptide binding]; other site 1046624002248 homodimer interface [polypeptide binding]; other site 1046624002249 active site 1046624002250 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1046624002251 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1046624002252 dimer interface [polypeptide binding]; other site 1046624002253 active site 1046624002254 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1046624002255 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1046624002256 carboxyltransferase (CT) interaction site; other site 1046624002257 biotinylation site [posttranslational modification]; other site 1046624002258 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1046624002259 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1046624002260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1046624002261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1046624002262 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1046624002263 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1046624002264 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 1046624002265 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1046624002266 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1046624002267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624002268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624002269 DNA binding site [nucleotide binding] 1046624002270 domain linker motif; other site 1046624002271 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1046624002272 dimerization interface [polypeptide binding]; other site 1046624002273 ligand binding site [chemical binding]; other site 1046624002274 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 1046624002275 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1046624002276 dimer interface [polypeptide binding]; other site 1046624002277 active site 1046624002278 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1046624002279 dimer interface [polypeptide binding]; other site 1046624002280 active site 1046624002281 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1046624002282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624002283 nucleotide binding site [chemical binding]; other site 1046624002284 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1046624002285 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1046624002286 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1046624002287 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1046624002288 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624002289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002290 active site 1046624002291 motif I; other site 1046624002292 motif II; other site 1046624002293 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624002294 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 1046624002295 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1046624002296 homodimer interface [polypeptide binding]; other site 1046624002297 substrate-cofactor binding pocket; other site 1046624002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624002299 catalytic residue [active] 1046624002300 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1046624002301 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1046624002302 dimer interface [polypeptide binding]; other site 1046624002303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624002304 catalytic residue [active] 1046624002305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1046624002306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1046624002307 active site residue [active] 1046624002308 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1046624002309 active site residue [active] 1046624002310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624002311 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1046624002312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624002313 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1046624002314 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1046624002315 active site residue [active] 1046624002316 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1046624002317 putative homodimer interface [polypeptide binding]; other site 1046624002318 putative homotetramer interface [polypeptide binding]; other site 1046624002319 putative metal binding site [ion binding]; other site 1046624002320 putative homodimer-homodimer interface [polypeptide binding]; other site 1046624002321 putative allosteric switch controlling residues; other site 1046624002322 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1046624002323 ArsC family; Region: ArsC; pfam03960 1046624002324 putative ArsC-like catalytic residues; other site 1046624002325 putative TRX-like catalytic residues [active] 1046624002326 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1046624002327 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1046624002328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1046624002329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1046624002330 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1046624002331 active site 1046624002332 putative catalytic site [active] 1046624002333 DNA binding site [nucleotide binding] 1046624002334 putative phosphate binding site [ion binding]; other site 1046624002335 metal binding site A [ion binding]; metal-binding site 1046624002336 AP binding site [nucleotide binding]; other site 1046624002337 metal binding site B [ion binding]; metal-binding site 1046624002338 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1046624002339 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1046624002340 active site 1046624002341 HIGH motif; other site 1046624002342 KMSKS motif; other site 1046624002343 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1046624002344 tRNA binding surface [nucleotide binding]; other site 1046624002345 anticodon binding site; other site 1046624002346 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1046624002347 dimer interface [polypeptide binding]; other site 1046624002348 putative tRNA-binding site [nucleotide binding]; other site 1046624002349 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1046624002350 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1046624002351 classical (c) SDRs; Region: SDR_c; cd05233 1046624002352 NAD(P) binding site [chemical binding]; other site 1046624002353 active site 1046624002354 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1046624002355 classical (c) SDRs; Region: SDR_c; cd05233 1046624002356 NAD(P) binding site [chemical binding]; other site 1046624002357 active site 1046624002358 Predicted membrane protein [Function unknown]; Region: COG4708 1046624002359 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1046624002360 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1046624002361 NAD binding site [chemical binding]; other site 1046624002362 substrate binding site [chemical binding]; other site 1046624002363 putative active site [active] 1046624002364 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1046624002365 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1046624002366 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1046624002367 heterotetramer interface [polypeptide binding]; other site 1046624002368 active site pocket [active] 1046624002369 cleavage site 1046624002370 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1046624002371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1046624002372 inhibitor-cofactor binding pocket; inhibition site 1046624002373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624002374 catalytic residue [active] 1046624002375 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1046624002376 feedback inhibition sensing region; other site 1046624002377 homohexameric interface [polypeptide binding]; other site 1046624002378 nucleotide binding site [chemical binding]; other site 1046624002379 N-acetyl-L-glutamate binding site [chemical binding]; other site 1046624002380 ornithine carbamoyltransferase; Validated; Region: PRK02102 1046624002381 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1046624002382 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1046624002383 ribonuclease III; Reviewed; Region: rnc; PRK00102 1046624002384 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1046624002385 dimerization interface [polypeptide binding]; other site 1046624002386 active site 1046624002387 metal binding site [ion binding]; metal-binding site 1046624002388 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1046624002389 dsRNA binding site [nucleotide binding]; other site 1046624002390 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1046624002391 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1046624002392 Walker A/P-loop; other site 1046624002393 ATP binding site [chemical binding]; other site 1046624002394 Q-loop/lid; other site 1046624002395 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1046624002396 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1046624002397 ABC transporter signature motif; other site 1046624002398 Walker B; other site 1046624002399 D-loop; other site 1046624002400 H-loop/switch region; other site 1046624002401 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1046624002402 Sulfatase; Region: Sulfatase; cl17466 1046624002403 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1046624002404 YibE/F-like protein; Region: YibE_F; cl02259 1046624002405 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1046624002406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002407 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624002408 active site 1046624002409 motif I; other site 1046624002410 motif II; other site 1046624002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002412 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1046624002413 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1046624002414 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1046624002415 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1046624002416 P loop; other site 1046624002417 GTP binding site [chemical binding]; other site 1046624002418 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1046624002419 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1046624002420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624002421 active site 1046624002422 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1046624002423 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1046624002424 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1046624002425 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1046624002426 HIGH motif; other site 1046624002427 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1046624002428 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624002429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624002430 active site 1046624002431 KMSKS motif; other site 1046624002432 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1046624002433 tRNA binding surface [nucleotide binding]; other site 1046624002434 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1046624002435 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624002436 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624002437 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624002438 putative active site [active] 1046624002439 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1046624002440 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1046624002441 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1046624002442 beta-galactosidase; Region: BGL; TIGR03356 1046624002443 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1046624002444 Lipase (class 2); Region: Lipase_2; pfam01674 1046624002445 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1046624002446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1046624002447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624002448 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1046624002449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624002450 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1046624002451 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1046624002452 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1046624002453 putative L-serine binding site [chemical binding]; other site 1046624002454 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1046624002455 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1046624002456 Predicted transcriptional regulator [Transcription]; Region: COG3682 1046624002457 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1046624002458 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1046624002459 metal-binding site [ion binding] 1046624002460 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1046624002461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1046624002462 metal-binding site [ion binding] 1046624002463 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624002464 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1046624002465 Predicted membrane protein [Function unknown]; Region: COG4485 1046624002466 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1046624002467 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1046624002468 nucleotide binding site/active site [active] 1046624002469 HIT family signature motif; other site 1046624002470 catalytic residue [active] 1046624002471 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1046624002472 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1046624002473 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1046624002474 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1046624002475 RNA binding site [nucleotide binding]; other site 1046624002476 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1046624002477 RNA binding site [nucleotide binding]; other site 1046624002478 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1046624002479 RNA binding site [nucleotide binding]; other site 1046624002480 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1046624002481 RNA binding site [nucleotide binding]; other site 1046624002482 Fibronectin-binding repeat; Region: SSURE; pfam11966 1046624002483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624002485 active site 1046624002486 phosphorylation site [posttranslational modification] 1046624002487 intermolecular recognition site; other site 1046624002488 dimerization interface [polypeptide binding]; other site 1046624002489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624002490 DNA binding site [nucleotide binding] 1046624002491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624002492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624002493 dimer interface [polypeptide binding]; other site 1046624002494 phosphorylation site [posttranslational modification] 1046624002495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624002496 ATP binding site [chemical binding]; other site 1046624002497 Mg2+ binding site [ion binding]; other site 1046624002498 G-X-G motif; other site 1046624002499 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1046624002500 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1046624002501 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1046624002502 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1046624002503 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1046624002504 GIY-YIG motif/motif A; other site 1046624002505 active site 1046624002506 catalytic site [active] 1046624002507 putative DNA binding site [nucleotide binding]; other site 1046624002508 metal binding site [ion binding]; metal-binding site 1046624002509 UvrB/uvrC motif; Region: UVR; pfam02151 1046624002510 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1046624002511 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1046624002512 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1046624002513 minor groove reading motif; other site 1046624002514 helix-hairpin-helix signature motif; other site 1046624002515 substrate binding pocket [chemical binding]; other site 1046624002516 active site 1046624002517 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1046624002518 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1046624002519 DNA binding and oxoG recognition site [nucleotide binding] 1046624002520 dipeptidase PepV; Region: dipeptidase; TIGR01886 1046624002521 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1046624002522 active site 1046624002523 metal binding site [ion binding]; metal-binding site 1046624002524 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1046624002525 alanine racemase; Reviewed; Region: alr; PRK00053 1046624002526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1046624002527 active site 1046624002528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1046624002529 dimer interface [polypeptide binding]; other site 1046624002530 substrate binding site [chemical binding]; other site 1046624002531 catalytic residues [active] 1046624002532 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1046624002533 ArsC family; Region: ArsC; pfam03960 1046624002534 putative catalytic residues [active] 1046624002535 thiol/disulfide switch; other site 1046624002536 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1046624002537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624002538 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1046624002539 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1046624002540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624002541 Walker A/P-loop; other site 1046624002542 ATP binding site [chemical binding]; other site 1046624002543 Q-loop/lid; other site 1046624002544 ABC transporter signature motif; other site 1046624002545 Walker B; other site 1046624002546 D-loop; other site 1046624002547 H-loop/switch region; other site 1046624002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624002549 ABC-ATPase subunit interface; other site 1046624002550 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1046624002551 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1046624002552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624002553 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1046624002554 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1046624002555 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1046624002556 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1046624002557 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1046624002558 homodimer interface [polypeptide binding]; other site 1046624002559 NADP binding site [chemical binding]; other site 1046624002560 substrate binding site [chemical binding]; other site 1046624002561 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1046624002562 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1046624002563 generic binding surface II; other site 1046624002564 generic binding surface I; other site 1046624002565 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1046624002566 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1046624002567 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1046624002568 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1046624002569 substrate binding pocket [chemical binding]; other site 1046624002570 chain length determination region; other site 1046624002571 substrate-Mg2+ binding site; other site 1046624002572 catalytic residues [active] 1046624002573 aspartate-rich region 1; other site 1046624002574 active site lid residues [active] 1046624002575 aspartate-rich region 2; other site 1046624002576 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1046624002577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624002578 RNA binding surface [nucleotide binding]; other site 1046624002579 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1046624002580 Arginine repressor [Transcription]; Region: ArgR; COG1438 1046624002581 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1046624002582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1046624002583 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1046624002584 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1046624002585 Walker A/P-loop; other site 1046624002586 ATP binding site [chemical binding]; other site 1046624002587 Q-loop/lid; other site 1046624002588 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1046624002589 ABC transporter signature motif; other site 1046624002590 Walker B; other site 1046624002591 D-loop; other site 1046624002592 H-loop/switch region; other site 1046624002593 Predicted integral membrane protein [Function unknown]; Region: COG3548 1046624002594 Predicted membrane protein [Function unknown]; Region: COG3152 1046624002595 Predicted membrane protein [Function unknown]; Region: COG3152 1046624002596 Predicted membrane protein [Function unknown]; Region: COG3152 1046624002597 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1046624002598 MraW methylase family; Region: Methyltransf_5; pfam01795 1046624002599 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1046624002600 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1046624002601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1046624002602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1046624002603 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1046624002604 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1046624002605 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1046624002606 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1046624002607 Mg++ binding site [ion binding]; other site 1046624002608 putative catalytic motif [active] 1046624002609 putative substrate binding site [chemical binding]; other site 1046624002610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624002611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624002612 Walker A/P-loop; other site 1046624002613 ATP binding site [chemical binding]; other site 1046624002614 Q-loop/lid; other site 1046624002615 ABC transporter signature motif; other site 1046624002616 Walker B; other site 1046624002617 D-loop; other site 1046624002618 H-loop/switch region; other site 1046624002619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624002620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624002621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1046624002622 dimerization interface [polypeptide binding]; other site 1046624002623 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1046624002624 synthetase active site [active] 1046624002625 NTP binding site [chemical binding]; other site 1046624002626 metal binding site [ion binding]; metal-binding site 1046624002627 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1046624002628 N-glycosyltransferase; Provisional; Region: PRK11204 1046624002629 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1046624002630 DXD motif; other site 1046624002631 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1046624002632 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 1046624002633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624002634 Ligand Binding Site [chemical binding]; other site 1046624002635 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1046624002636 IHF dimer interface [polypeptide binding]; other site 1046624002637 IHF - DNA interface [nucleotide binding]; other site 1046624002638 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1046624002639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624002640 Predicted membrane protein [Function unknown]; Region: COG1511 1046624002641 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1046624002642 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1046624002643 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1046624002644 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1046624002645 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1046624002646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1046624002647 active site 1046624002648 DNA binding site [nucleotide binding] 1046624002649 Int/Topo IB signature motif; other site 1046624002650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1046624002651 Transposase; Region: HTH_Tnp_1; pfam01527 1046624002652 putative transposase OrfB; Reviewed; Region: PHA02517 1046624002653 Integrase core domain; Region: rve; pfam00665 1046624002654 Integrase core domain; Region: rve_3; pfam13683 1046624002655 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1046624002656 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1046624002657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624002658 ATP binding site [chemical binding]; other site 1046624002659 putative Mg++ binding site [ion binding]; other site 1046624002660 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1046624002661 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1046624002662 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1046624002663 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624002664 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1046624002665 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624002666 putative nonsense mutation 1046624002667 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1046624002668 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1046624002669 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1046624002670 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1046624002671 Predicted membrane protein [Function unknown]; Region: COG4758 1046624002672 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1046624002673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624002674 Histidine kinase; Region: HisKA_3; pfam07730 1046624002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624002676 ATP binding site [chemical binding]; other site 1046624002677 Mg2+ binding site [ion binding]; other site 1046624002678 G-X-G motif; other site 1046624002679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1046624002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624002681 active site 1046624002682 phosphorylation site [posttranslational modification] 1046624002683 intermolecular recognition site; other site 1046624002684 dimerization interface [polypeptide binding]; other site 1046624002685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1046624002686 DNA binding residues [nucleotide binding] 1046624002687 dimerization interface [polypeptide binding]; other site 1046624002688 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624002689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002690 motif II; other site 1046624002691 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624002692 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1046624002693 active site 1046624002694 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1046624002695 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1046624002696 RNA binding site [nucleotide binding]; other site 1046624002697 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1046624002698 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1046624002699 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1046624002700 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1046624002701 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1046624002702 putative NAD(P) binding site [chemical binding]; other site 1046624002703 catalytic Zn binding site [ion binding]; other site 1046624002704 acetoin reductase; Validated; Region: PRK08643 1046624002705 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1046624002706 NAD binding site [chemical binding]; other site 1046624002707 homotetramer interface [polypeptide binding]; other site 1046624002708 homodimer interface [polypeptide binding]; other site 1046624002709 active site 1046624002710 substrate binding site [chemical binding]; other site 1046624002711 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1046624002712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624002713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624002714 ABC transporter; Region: ABC_tran_2; pfam12848 1046624002715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624002716 malate dehydrogenase; Provisional; Region: PRK13529 1046624002717 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1046624002718 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1046624002719 NAD(P) binding site [chemical binding]; other site 1046624002720 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1046624002721 EamA-like transporter family; Region: EamA; pfam00892 1046624002722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1046624002723 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1046624002724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624002725 motif II; other site 1046624002726 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1046624002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624002728 Mg2+ binding site [ion binding]; other site 1046624002729 G-X-G motif; other site 1046624002730 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1046624002731 anchoring element; other site 1046624002732 dimer interface [polypeptide binding]; other site 1046624002733 ATP binding site [chemical binding]; other site 1046624002734 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1046624002735 active site 1046624002736 putative metal-binding site [ion binding]; other site 1046624002737 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1046624002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624002739 S-adenosylmethionine binding site [chemical binding]; other site 1046624002740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624002741 MarR family; Region: MarR_2; pfam12802 1046624002742 MarR family; Region: MarR_2; cl17246 1046624002743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624002744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624002745 putative substrate translocation pore; other site 1046624002746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624002747 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1046624002748 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1046624002749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1046624002750 active site 1046624002751 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1046624002752 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1046624002753 Walker A/P-loop; other site 1046624002754 ATP binding site [chemical binding]; other site 1046624002755 Q-loop/lid; other site 1046624002756 ABC transporter signature motif; other site 1046624002757 Walker B; other site 1046624002758 D-loop; other site 1046624002759 H-loop/switch region; other site 1046624002760 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1046624002761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624002762 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1046624002763 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1046624002764 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1046624002765 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1046624002766 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1046624002767 Ligand binding site; other site 1046624002768 metal-binding site 1046624002769 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1046624002770 putative trimer interface [polypeptide binding]; other site 1046624002771 putative CoA binding site [chemical binding]; other site 1046624002772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1046624002773 Sel1-like repeats; Region: SEL1; smart00671 1046624002774 Sel1-like repeats; Region: SEL1; smart00671 1046624002775 Sel1-like repeats; Region: SEL1; smart00671 1046624002776 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624002777 active site 1046624002778 HIGH motif; other site 1046624002779 nucleotide binding site [chemical binding]; other site 1046624002780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624002781 active site 1046624002782 KMSKS motif; other site 1046624002783 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1046624002784 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1046624002785 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1046624002786 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1046624002787 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1046624002788 phosphopentomutase; Provisional; Region: PRK05362 1046624002789 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1046624002790 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1046624002791 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1046624002792 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1046624002793 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1046624002794 hypothetical protein; Provisional; Region: PRK00967 1046624002795 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1046624002796 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1046624002797 Potassium binding sites [ion binding]; other site 1046624002798 Cesium cation binding sites [ion binding]; other site 1046624002799 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1046624002800 NlpC/P60 family; Region: NLPC_P60; pfam00877 1046624002801 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1046624002802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1046624002803 substrate binding pocket [chemical binding]; other site 1046624002804 membrane-bound complex binding site; other site 1046624002805 hinge residues; other site 1046624002806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624002807 dimer interface [polypeptide binding]; other site 1046624002808 conserved gate region; other site 1046624002809 putative PBP binding loops; other site 1046624002810 ABC-ATPase subunit interface; other site 1046624002811 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1046624002812 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1046624002813 Walker A/P-loop; other site 1046624002814 ATP binding site [chemical binding]; other site 1046624002815 Q-loop/lid; other site 1046624002816 ABC transporter signature motif; other site 1046624002817 Walker B; other site 1046624002818 D-loop; other site 1046624002819 H-loop/switch region; other site 1046624002820 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1046624002821 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1046624002822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624002823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624002824 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1046624002825 ribonuclease R; Region: RNase_R; TIGR02063 1046624002826 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1046624002827 RNB domain; Region: RNB; pfam00773 1046624002828 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1046624002829 RNA binding site [nucleotide binding]; other site 1046624002830 Isochorismatase family; Region: Isochorismatase; pfam00857 1046624002831 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1046624002832 catalytic triad [active] 1046624002833 conserved cis-peptide bond; other site 1046624002834 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1046624002835 putative catalytic site [active] 1046624002836 putative metal binding site [ion binding]; other site 1046624002837 putative phosphate binding site [ion binding]; other site 1046624002838 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 1046624002839 UbiA prenyltransferase family; Region: UbiA; pfam01040 1046624002840 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1046624002841 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1046624002842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624002843 catalytic core [active] 1046624002844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624002845 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1046624002846 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1046624002847 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 1046624002848 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1046624002849 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1046624002850 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1046624002851 dimer interface [polypeptide binding]; other site 1046624002852 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1046624002853 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1046624002854 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1046624002855 nucleotide binding site [chemical binding]; other site 1046624002856 NEF interaction site [polypeptide binding]; other site 1046624002857 SBD interface [polypeptide binding]; other site 1046624002858 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1046624002859 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1046624002860 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1046624002861 metal binding site [ion binding]; metal-binding site 1046624002862 dimer interface [polypeptide binding]; other site 1046624002863 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1046624002864 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1046624002865 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1046624002866 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1046624002867 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1046624002868 putative substrate binding site [chemical binding]; other site 1046624002869 putative ATP binding site [chemical binding]; other site 1046624002870 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1046624002871 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1046624002872 active site 1046624002873 phosphorylation site [posttranslational modification] 1046624002874 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1046624002875 active site 1046624002876 P-loop; other site 1046624002877 phosphorylation site [posttranslational modification] 1046624002878 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1046624002879 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1046624002880 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1046624002881 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1046624002882 putative active site [active] 1046624002883 catalytic site [active] 1046624002884 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1046624002885 putative active site [active] 1046624002886 catalytic site [active] 1046624002887 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1046624002888 AAA domain; Region: AAA_18; pfam13238 1046624002889 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1046624002890 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1046624002891 dimer interface [polypeptide binding]; other site 1046624002892 phosphate binding site [ion binding]; other site 1046624002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1046624002894 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1046624002895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624002896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624002897 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1046624002898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1046624002899 Walker A/P-loop; other site 1046624002900 ATP binding site [chemical binding]; other site 1046624002901 Q-loop/lid; other site 1046624002902 ABC transporter signature motif; other site 1046624002903 Walker B; other site 1046624002904 D-loop; other site 1046624002905 H-loop/switch region; other site 1046624002906 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1046624002907 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1046624002908 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1046624002909 hypothetical protein; Provisional; Region: PRK13662 1046624002910 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1046624002911 putative phosphoesterase; Region: acc_ester; TIGR03729 1046624002912 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1046624002913 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1046624002914 RF-1 domain; Region: RF-1; pfam00472 1046624002915 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1046624002916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624002917 Walker A/P-loop; other site 1046624002918 ATP binding site [chemical binding]; other site 1046624002919 Q-loop/lid; other site 1046624002920 ABC transporter signature motif; other site 1046624002921 Walker B; other site 1046624002922 D-loop; other site 1046624002923 H-loop/switch region; other site 1046624002924 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1046624002925 FtsX-like permease family; Region: FtsX; pfam02687 1046624002926 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1046624002927 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1046624002928 dimer interface [polypeptide binding]; other site 1046624002929 putative radical transfer pathway; other site 1046624002930 diiron center [ion binding]; other site 1046624002931 tyrosyl radical; other site 1046624002932 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1046624002933 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1046624002934 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1046624002935 active site 1046624002936 dimer interface [polypeptide binding]; other site 1046624002937 catalytic residues [active] 1046624002938 effector binding site; other site 1046624002939 R2 peptide binding site; other site 1046624002940 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1046624002941 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1046624002942 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1046624002943 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1046624002944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624002945 Mg2+ binding site [ion binding]; other site 1046624002946 G-X-G motif; other site 1046624002947 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1046624002948 anchoring element; other site 1046624002949 dimer interface [polypeptide binding]; other site 1046624002950 ATP binding site [chemical binding]; other site 1046624002951 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1046624002952 active site 1046624002953 putative metal-binding site [ion binding]; other site 1046624002954 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1046624002955 Isochorismatase family; Region: Isochorismatase; pfam00857 1046624002956 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1046624002957 catalytic triad [active] 1046624002958 conserved cis-peptide bond; other site 1046624002959 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1046624002960 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1046624002961 active site 1046624002962 catalytic site [active] 1046624002963 substrate binding site [chemical binding]; other site 1046624002964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624002965 Coenzyme A binding pocket [chemical binding]; other site 1046624002966 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1046624002967 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1046624002968 CAP-like domain; other site 1046624002969 active site 1046624002970 primary dimer interface [polypeptide binding]; other site 1046624002971 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624002972 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1046624002973 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1046624002974 oligomer interface [polypeptide binding]; other site 1046624002975 Cl binding site [ion binding]; other site 1046624002976 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1046624002977 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1046624002978 catalytic motif [active] 1046624002979 Zn binding site [ion binding]; other site 1046624002980 RibD C-terminal domain; Region: RibD_C; cl17279 1046624002981 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1046624002982 Lumazine binding domain; Region: Lum_binding; pfam00677 1046624002983 Lumazine binding domain; Region: Lum_binding; pfam00677 1046624002984 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1046624002985 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1046624002986 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1046624002987 dimerization interface [polypeptide binding]; other site 1046624002988 active site 1046624002989 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1046624002990 homopentamer interface [polypeptide binding]; other site 1046624002991 active site 1046624002992 lipoprotein signal peptidase; Provisional; Region: PRK14797 1046624002993 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1046624002994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624002995 RNA binding surface [nucleotide binding]; other site 1046624002996 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1046624002997 active site 1046624002998 Divergent PAP2 family; Region: DUF212; pfam02681 1046624002999 conserved hypothetical integral membrane protein; Region: TIGR03766 1046624003000 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1046624003001 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1046624003002 Ligand binding site; other site 1046624003003 Putative Catalytic site; other site 1046624003004 DXD motif; other site 1046624003005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624003006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624003007 active site 1046624003008 phosphorylation site [posttranslational modification] 1046624003009 intermolecular recognition site; other site 1046624003010 dimerization interface [polypeptide binding]; other site 1046624003011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624003012 DNA binding site [nucleotide binding] 1046624003013 Predicted membrane protein [Function unknown]; Region: COG4331 1046624003014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624003015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624003016 dimer interface [polypeptide binding]; other site 1046624003017 phosphorylation site [posttranslational modification] 1046624003018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624003019 ATP binding site [chemical binding]; other site 1046624003020 Mg2+ binding site [ion binding]; other site 1046624003021 G-X-G motif; other site 1046624003022 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1046624003023 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1046624003024 active site 1046624003025 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1046624003026 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1046624003027 glutaminase active site [active] 1046624003028 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1046624003029 dimer interface [polypeptide binding]; other site 1046624003030 active site 1046624003031 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1046624003032 dimer interface [polypeptide binding]; other site 1046624003033 active site 1046624003034 hypothetical protein; Reviewed; Region: PRK00024 1046624003035 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1046624003036 MPN+ (JAMM) motif; other site 1046624003037 Zinc-binding site [ion binding]; other site 1046624003038 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1046624003039 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1046624003040 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1046624003041 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 1046624003042 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1046624003043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624003044 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1046624003045 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1046624003046 CoA binding domain; Region: CoA_binding; pfam02629 1046624003047 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1046624003048 ArsC family; Region: ArsC; pfam03960 1046624003049 putative catalytic residues [active] 1046624003050 thiol/disulfide switch; other site 1046624003051 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1046624003052 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624003053 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624003054 ABC transporter; Region: ABC_tran_2; pfam12848 1046624003055 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624003056 putative nonsense mutation 1046624003057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624003058 non-specific DNA binding site [nucleotide binding]; other site 1046624003059 salt bridge; other site 1046624003060 sequence-specific DNA binding site [nucleotide binding]; other site 1046624003061 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624003062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624003063 active site 1046624003064 dihydroorotase; Validated; Region: pyrC; PRK09357 1046624003065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1046624003066 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1046624003067 active site 1046624003068 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1046624003069 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1046624003070 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1046624003071 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1046624003072 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1046624003073 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1046624003074 active site 1046624003075 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1046624003076 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1046624003077 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1046624003078 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1046624003079 minor groove reading motif; other site 1046624003080 helix-hairpin-helix signature motif; other site 1046624003081 substrate binding pocket [chemical binding]; other site 1046624003082 active site 1046624003083 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1046624003084 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1046624003085 Family of unknown function (DUF633); Region: DUF633; pfam04816 1046624003086 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1046624003087 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1046624003088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1046624003089 sugar phosphate phosphatase; Provisional; Region: PRK10513 1046624003090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003091 active site 1046624003092 motif I; other site 1046624003093 motif II; other site 1046624003094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003095 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1046624003096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624003097 Zn2+ binding site [ion binding]; other site 1046624003098 Mg2+ binding site [ion binding]; other site 1046624003099 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1046624003100 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1046624003101 Predicted membrane protein [Function unknown]; Region: COG3371 1046624003102 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1046624003103 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1046624003104 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1046624003105 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1046624003106 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1046624003107 manganese transport protein MntH; Reviewed; Region: PRK00701 1046624003108 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1046624003109 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1046624003110 PhoH-like protein; Region: PhoH; pfam02562 1046624003111 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1046624003112 nudix motif; other site 1046624003113 metal-binding heat shock protein; Provisional; Region: PRK00016 1046624003114 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1046624003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 1046624003116 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1046624003117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624003118 active site 1046624003119 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1046624003120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624003121 ATP binding site [chemical binding]; other site 1046624003122 putative Mg++ binding site [ion binding]; other site 1046624003123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624003124 nucleotide binding region [chemical binding]; other site 1046624003125 ATP-binding site [chemical binding]; other site 1046624003126 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1046624003127 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1046624003128 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1046624003129 VanZ like family; Region: VanZ; pfam04892 1046624003130 hypothetical protein; Provisional; Region: PRK14013 1046624003131 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1046624003132 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1046624003133 active site 1046624003134 metal binding site [ion binding]; metal-binding site 1046624003135 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1046624003136 motif 1; other site 1046624003137 dimer interface [polypeptide binding]; other site 1046624003138 active site 1046624003139 motif 2; other site 1046624003140 motif 3; other site 1046624003141 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1046624003142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1046624003143 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1046624003144 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1046624003145 putative Cl- selectivity filter; other site 1046624003146 putative pore gating glutamate residue; other site 1046624003147 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1046624003148 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1046624003149 active site 1046624003150 (T/H)XGH motif; other site 1046624003151 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1046624003152 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1046624003153 active site 1046624003154 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1046624003155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624003156 Coenzyme A binding pocket [chemical binding]; other site 1046624003157 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1046624003158 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1046624003159 homodimer interface [polypeptide binding]; other site 1046624003160 NAD binding pocket [chemical binding]; other site 1046624003161 ATP binding pocket [chemical binding]; other site 1046624003162 Mg binding site [ion binding]; other site 1046624003163 active-site loop [active] 1046624003164 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624003165 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624003166 Walker A/P-loop; other site 1046624003167 ATP binding site [chemical binding]; other site 1046624003168 Q-loop/lid; other site 1046624003169 ABC transporter signature motif; other site 1046624003170 Walker B; other site 1046624003171 D-loop; other site 1046624003172 H-loop/switch region; other site 1046624003173 FtsX-like permease family; Region: FtsX; pfam02687 1046624003174 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1046624003175 FtsX-like permease family; Region: FtsX; pfam02687 1046624003176 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1046624003177 catalytic triad [active] 1046624003178 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1046624003179 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624003180 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1046624003181 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1046624003182 GTP-binding protein LepA; Provisional; Region: PRK05433 1046624003183 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1046624003184 G1 box; other site 1046624003185 putative GEF interaction site [polypeptide binding]; other site 1046624003186 GTP/Mg2+ binding site [chemical binding]; other site 1046624003187 Switch I region; other site 1046624003188 G2 box; other site 1046624003189 G3 box; other site 1046624003190 Switch II region; other site 1046624003191 G4 box; other site 1046624003192 G5 box; other site 1046624003193 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1046624003194 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1046624003195 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1046624003196 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1046624003197 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1046624003198 NAD(P) binding site [chemical binding]; other site 1046624003199 putative active site [active] 1046624003200 Amino acid permease; Region: AA_permease_2; pfam13520 1046624003201 DNA gyrase subunit A; Validated; Region: PRK05560 1046624003202 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1046624003203 CAP-like domain; other site 1046624003204 active site 1046624003205 primary dimer interface [polypeptide binding]; other site 1046624003206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003210 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003211 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1046624003212 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1046624003213 ApbE family; Region: ApbE; pfam02424 1046624003214 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1046624003215 active site 1046624003216 catalytic site [active] 1046624003217 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1046624003218 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1046624003219 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1046624003220 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1046624003221 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1046624003222 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 1046624003223 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1046624003224 dimer interface [polypeptide binding]; other site 1046624003225 putative anticodon binding site; other site 1046624003226 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1046624003227 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1046624003228 Part of AAA domain; Region: AAA_19; pfam13245 1046624003229 Family description; Region: UvrD_C_2; pfam13538 1046624003230 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1046624003231 putative active site [active] 1046624003232 nucleotide binding site [chemical binding]; other site 1046624003233 nudix motif; other site 1046624003234 putative metal binding site [ion binding]; other site 1046624003235 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1046624003236 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1046624003237 dimer interface [polypeptide binding]; other site 1046624003238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624003239 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1046624003240 L-aspartate oxidase; Provisional; Region: PRK06175 1046624003241 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1046624003242 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1046624003243 RNA binding site [nucleotide binding]; other site 1046624003244 active site 1046624003245 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1046624003246 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1046624003247 active site 1046624003248 Riboflavin kinase; Region: Flavokinase; smart00904 1046624003249 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1046624003250 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1046624003251 dimer interface [polypeptide binding]; other site 1046624003252 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624003253 NAD binding site [chemical binding]; other site 1046624003254 substrate binding site [chemical binding]; other site 1046624003255 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1046624003256 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1046624003257 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1046624003258 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1046624003259 putative active site [active] 1046624003260 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1046624003261 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1046624003262 active site turn [active] 1046624003263 phosphorylation site [posttranslational modification] 1046624003264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1046624003265 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1046624003266 HPr interaction site; other site 1046624003267 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1046624003268 active site 1046624003269 phosphorylation site [posttranslational modification] 1046624003270 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624003271 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624003272 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624003273 putative active site [active] 1046624003274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1046624003275 triosephosphate isomerase; Provisional; Region: PRK14565 1046624003276 substrate binding site [chemical binding]; other site 1046624003277 dimer interface [polypeptide binding]; other site 1046624003278 catalytic triad [active] 1046624003279 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1046624003280 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1046624003281 active site 1046624003282 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1046624003283 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1046624003284 Active Sites [active] 1046624003285 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1046624003286 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1046624003287 ParB-like nuclease domain; Region: ParB; smart00470 1046624003288 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1046624003289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624003290 FeS/SAM binding site; other site 1046624003291 HemN C-terminal domain; Region: HemN_C; pfam06969 1046624003292 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1046624003293 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1046624003294 active site 1046624003295 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1046624003296 catalytic motif [active] 1046624003297 Zn binding site [ion binding]; other site 1046624003298 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1046624003299 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1046624003300 active site 1046624003301 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1046624003302 active site 2 [active] 1046624003303 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1046624003304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003305 active site 1046624003306 motif I; other site 1046624003307 motif II; other site 1046624003308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003309 Predicted membrane protein [Function unknown]; Region: COG4478 1046624003310 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1046624003311 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1046624003312 active site 1046624003313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624003314 active site 1046624003315 xanthine permease; Region: pbuX; TIGR03173 1046624003316 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1046624003317 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1046624003318 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1046624003319 folate binding site [chemical binding]; other site 1046624003320 NADP+ binding site [chemical binding]; other site 1046624003321 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1046624003322 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1046624003323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624003324 Walker A motif; other site 1046624003325 ATP binding site [chemical binding]; other site 1046624003326 Walker B motif; other site 1046624003327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1046624003328 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1046624003329 G1 box; other site 1046624003330 GTP/Mg2+ binding site [chemical binding]; other site 1046624003331 Switch I region; other site 1046624003332 G2 box; other site 1046624003333 G3 box; other site 1046624003334 Switch II region; other site 1046624003335 G4 box; other site 1046624003336 G5 box; other site 1046624003337 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1046624003338 active site 1046624003339 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1046624003340 catalytic center binding site [active] 1046624003341 ATP binding site [chemical binding]; other site 1046624003342 GTP cyclohydrolase I [Coenzyme metabolism]; Region: FolE; COG0302 1046624003343 GTP cyclohydrolase I; Provisional; Region: PLN03044 1046624003344 active site 1046624003345 dihydropteroate synthase; Region: DHPS; TIGR01496 1046624003346 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1046624003347 substrate binding pocket [chemical binding]; other site 1046624003348 dimer interface [polypeptide binding]; other site 1046624003349 inhibitor binding site; inhibition site 1046624003350 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1046624003351 nudix motif; other site 1046624003352 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1046624003353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624003354 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1046624003355 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1046624003356 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1046624003357 Substrate-binding site [chemical binding]; other site 1046624003358 Substrate specificity [chemical binding]; other site 1046624003359 homoserine dehydrogenase; Provisional; Region: PRK06349 1046624003360 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1046624003361 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1046624003362 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1046624003363 homoserine kinase; Provisional; Region: PRK01212 1046624003364 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1046624003365 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1046624003366 FAD binding domain; Region: FAD_binding_4; pfam01565 1046624003367 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1046624003368 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1046624003369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624003370 Walker A/P-loop; other site 1046624003371 ATP binding site [chemical binding]; other site 1046624003372 Q-loop/lid; other site 1046624003373 ABC transporter signature motif; other site 1046624003374 Walker B; other site 1046624003375 D-loop; other site 1046624003376 H-loop/switch region; other site 1046624003377 TOBE domain; Region: TOBE_2; pfam08402 1046624003378 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 1046624003379 dimer interface [polypeptide binding]; other site 1046624003380 conserved gate region; other site 1046624003381 putative PBP binding loops; other site 1046624003382 ABC-ATPase subunit interface; other site 1046624003383 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1046624003384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624003385 dimer interface [polypeptide binding]; other site 1046624003386 conserved gate region; other site 1046624003387 putative PBP binding loops; other site 1046624003388 ABC-ATPase subunit interface; other site 1046624003389 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1046624003390 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1046624003391 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1046624003392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624003393 Walker A/P-loop; other site 1046624003394 ATP binding site [chemical binding]; other site 1046624003395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624003396 ABC transporter signature motif; other site 1046624003397 Walker B; other site 1046624003398 D-loop; other site 1046624003399 H-loop/switch region; other site 1046624003400 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624003401 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1046624003402 B12 binding site [chemical binding]; other site 1046624003403 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1046624003404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1046624003405 FeS/SAM binding site; other site 1046624003406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624003407 putative substrate translocation pore; other site 1046624003408 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1046624003409 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1046624003410 putative active site [active] 1046624003411 catalytic site [active] 1046624003412 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1046624003413 putative active site [active] 1046624003414 catalytic site [active] 1046624003415 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1046624003416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624003417 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1046624003418 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1046624003419 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1046624003420 putative active site cavity [active] 1046624003421 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1046624003422 TRAM domain; Region: TRAM; cl01282 1046624003423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624003424 S-adenosylmethionine binding site [chemical binding]; other site 1046624003425 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1046624003426 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1046624003427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624003428 S-adenosylmethionine binding site [chemical binding]; other site 1046624003429 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1046624003430 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1046624003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1046624003432 binding surface 1046624003433 TPR motif; other site 1046624003434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1046624003435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1046624003436 binding surface 1046624003437 TPR motif; other site 1046624003438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1046624003439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1046624003440 binding surface 1046624003441 TPR motif; other site 1046624003442 acetolactate synthase; Reviewed; Region: PRK08617 1046624003443 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1046624003444 PYR/PP interface [polypeptide binding]; other site 1046624003445 dimer interface [polypeptide binding]; other site 1046624003446 TPP binding site [chemical binding]; other site 1046624003447 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1046624003448 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1046624003449 TPP-binding site [chemical binding]; other site 1046624003450 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1046624003451 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1046624003452 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1046624003453 Ligand Binding Site [chemical binding]; other site 1046624003454 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1046624003455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624003456 dimer interface [polypeptide binding]; other site 1046624003457 phosphorylation site [posttranslational modification] 1046624003458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624003459 ATP binding site [chemical binding]; other site 1046624003460 Mg2+ binding site [ion binding]; other site 1046624003461 G-X-G motif; other site 1046624003462 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1046624003463 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1046624003464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624003465 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1046624003466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624003467 non-specific DNA binding site [nucleotide binding]; other site 1046624003468 salt bridge; other site 1046624003469 sequence-specific DNA binding site [nucleotide binding]; other site 1046624003470 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003472 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003473 ribonuclease R; Region: RNase_R; TIGR02063 1046624003474 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1046624003475 RNB domain; Region: RNB; pfam00773 1046624003476 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1046624003477 RNA binding site [nucleotide binding]; other site 1046624003478 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1046624003479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624003480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624003481 homodimer interface [polypeptide binding]; other site 1046624003482 catalytic residue [active] 1046624003483 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1046624003484 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1046624003485 dimer interface [polypeptide binding]; other site 1046624003486 motif 1; other site 1046624003487 active site 1046624003488 motif 2; other site 1046624003489 motif 3; other site 1046624003490 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1046624003491 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1046624003492 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1046624003493 histidinol dehydrogenase; Region: hisD; TIGR00069 1046624003494 NAD binding site [chemical binding]; other site 1046624003495 dimerization interface [polypeptide binding]; other site 1046624003496 product binding site; other site 1046624003497 substrate binding site [chemical binding]; other site 1046624003498 zinc binding site [ion binding]; other site 1046624003499 catalytic residues [active] 1046624003500 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1046624003501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1046624003502 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1046624003503 putative active site pocket [active] 1046624003504 4-fold oligomerization interface [polypeptide binding]; other site 1046624003505 metal binding residues [ion binding]; metal-binding site 1046624003506 3-fold/trimer interface [polypeptide binding]; other site 1046624003507 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1046624003508 active site 1046624003509 ATP binding site [chemical binding]; other site 1046624003510 Phosphotransferase enzyme family; Region: APH; pfam01636 1046624003511 antibiotic binding site [chemical binding]; other site 1046624003512 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1046624003513 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1046624003514 putative active site [active] 1046624003515 oxyanion strand; other site 1046624003516 catalytic triad [active] 1046624003517 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1046624003518 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1046624003519 catalytic residues [active] 1046624003520 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1046624003521 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1046624003522 substrate binding site [chemical binding]; other site 1046624003523 glutamase interaction surface [polypeptide binding]; other site 1046624003524 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1046624003525 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1046624003526 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1046624003527 metal binding site [ion binding]; metal-binding site 1046624003528 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1046624003529 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1046624003530 active site 1046624003531 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1046624003532 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1046624003533 active site residue [active] 1046624003534 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1046624003535 2-isopropylmalate synthase; Validated; Region: PRK00915 1046624003536 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1046624003537 active site 1046624003538 catalytic residues [active] 1046624003539 metal binding site [ion binding]; metal-binding site 1046624003540 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1046624003541 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1046624003542 tartrate dehydrogenase; Region: TTC; TIGR02089 1046624003543 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1046624003544 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1046624003545 substrate binding site [chemical binding]; other site 1046624003546 ligand binding site [chemical binding]; other site 1046624003547 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1046624003548 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1046624003549 substrate binding site [chemical binding]; other site 1046624003550 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1046624003551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1046624003552 Walker A/P-loop; other site 1046624003553 ATP binding site [chemical binding]; other site 1046624003554 Q-loop/lid; other site 1046624003555 ABC transporter signature motif; other site 1046624003556 Walker B; other site 1046624003557 D-loop; other site 1046624003558 H-loop/switch region; other site 1046624003559 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1046624003560 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1046624003561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1046624003562 PYR/PP interface [polypeptide binding]; other site 1046624003563 dimer interface [polypeptide binding]; other site 1046624003564 TPP binding site [chemical binding]; other site 1046624003565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1046624003566 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1046624003567 TPP-binding site [chemical binding]; other site 1046624003568 dimer interface [polypeptide binding]; other site 1046624003569 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1046624003570 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1046624003571 putative valine binding site [chemical binding]; other site 1046624003572 dimer interface [polypeptide binding]; other site 1046624003573 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1046624003574 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1046624003575 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1046624003576 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1046624003577 threonine dehydratase; Validated; Region: PRK08639 1046624003578 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1046624003579 tetramer interface [polypeptide binding]; other site 1046624003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624003581 catalytic residue [active] 1046624003582 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1046624003583 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1046624003584 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1046624003585 homotrimer interaction site [polypeptide binding]; other site 1046624003586 putative active site [active] 1046624003587 DNA protecting protein DprA; Region: dprA; TIGR00732 1046624003588 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1046624003589 DNA topoisomerase I; Validated; Region: PRK05582 1046624003590 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1046624003591 active site 1046624003592 interdomain interaction site; other site 1046624003593 putative metal-binding site [ion binding]; other site 1046624003594 nucleotide binding site [chemical binding]; other site 1046624003595 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1046624003596 domain I; other site 1046624003597 DNA binding groove [nucleotide binding] 1046624003598 phosphate binding site [ion binding]; other site 1046624003599 domain II; other site 1046624003600 domain III; other site 1046624003601 nucleotide binding site [chemical binding]; other site 1046624003602 catalytic site [active] 1046624003603 domain IV; other site 1046624003604 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1046624003605 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1046624003606 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1046624003607 Glucose inhibited division protein A; Region: GIDA; pfam01134 1046624003608 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1046624003609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1046624003610 active site 1046624003611 DNA binding site [nucleotide binding] 1046624003612 Int/Topo IB signature motif; other site 1046624003613 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1046624003614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1046624003615 active site 1046624003616 DNA binding site [nucleotide binding] 1046624003617 Int/Topo IB signature motif; other site 1046624003618 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1046624003619 recombinase A; Provisional; Region: recA; PRK09354 1046624003620 Walker A motif; other site 1046624003621 ATP binding site [chemical binding]; other site 1046624003622 Walker B motif; other site 1046624003623 DNA polymerase IV; Reviewed; Region: PRK03103 1046624003624 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1046624003625 active site 1046624003626 DNA binding site [nucleotide binding] 1046624003627 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1046624003628 HTH-like domain; Region: HTH_21; pfam13276 1046624003629 Integrase core domain; Region: rve; pfam00665 1046624003630 Integrase core domain; Region: rve_2; pfam13333 1046624003631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1046624003632 Helix-turn-helix domain; Region: HTH_28; pfam13518 1046624003633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1046624003634 Transposase; Region: HTH_Tnp_1; cl17663 1046624003635 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1046624003636 ATP binding site [chemical binding]; other site 1046624003637 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1046624003638 active site 1046624003639 NTP binding site [chemical binding]; other site 1046624003640 metal binding triad [ion binding]; metal-binding site 1046624003641 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1046624003642 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624003643 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624003644 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1046624003645 Int/Topo IB signature motif; other site 1046624003646 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624003647 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1046624003648 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624003649 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1046624003650 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1046624003651 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1046624003652 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1046624003653 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1046624003654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624003655 ATP binding site [chemical binding]; other site 1046624003656 putative Mg++ binding site [ion binding]; other site 1046624003657 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1046624003658 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1046624003659 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1046624003660 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1046624003661 Domain of unknown function (DUF955); Region: DUF955; cl01076 1046624003662 hypothetical protein; Provisional; Region: PRK11281 1046624003663 Peptidase family M23; Region: Peptidase_M23; pfam01551 1046624003664 Surface antigen [General function prediction only]; Region: COG3942 1046624003665 CHAP domain; Region: CHAP; pfam05257 1046624003666 AAA-like domain; Region: AAA_10; pfam12846 1046624003667 AAA-like domain; Region: AAA_10; pfam12846 1046624003668 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1046624003669 Walker A motif; other site 1046624003670 ATP binding site [chemical binding]; other site 1046624003671 Walker B motif; other site 1046624003672 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1046624003673 hypothetical protein; Provisional; Region: PRK11281 1046624003674 AAA domain; Region: AAA_31; pfam13614 1046624003675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1046624003676 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1046624003677 Helix-turn-helix domain; Region: HTH_36; pfam13730 1046624003678 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1046624003679 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1046624003680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624003681 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1046624003682 NAD(P) binding site [chemical binding]; other site 1046624003683 active site 1046624003684 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1046624003685 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1046624003686 potential catalytic triad [active] 1046624003687 conserved cys residue [active] 1046624003688 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1046624003689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1046624003690 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 1046624003691 putative active site [active] 1046624003692 putative ligand binding site [chemical binding]; other site 1046624003693 putative NAD(P) binding site [chemical binding]; other site 1046624003694 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1046624003695 oligomer interface [polypeptide binding]; other site 1046624003696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1046624003697 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 1046624003698 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1046624003699 Predicted membrane protein [Function unknown]; Region: COG2261 1046624003700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624003701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624003702 active site 1046624003703 catalytic tetrad [active] 1046624003704 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1046624003705 amphipathic channel; other site 1046624003706 Asn-Pro-Ala signature motifs; other site 1046624003707 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1046624003708 glycerol kinase; Provisional; Region: glpK; PRK00047 1046624003709 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1046624003710 N- and C-terminal domain interface [polypeptide binding]; other site 1046624003711 active site 1046624003712 MgATP binding site [chemical binding]; other site 1046624003713 catalytic site [active] 1046624003714 metal binding site [ion binding]; metal-binding site 1046624003715 glycerol binding site [chemical binding]; other site 1046624003716 homotetramer interface [polypeptide binding]; other site 1046624003717 homodimer interface [polypeptide binding]; other site 1046624003718 FBP binding site [chemical binding]; other site 1046624003719 protein IIAGlc interface [polypeptide binding]; other site 1046624003720 Mga helix-turn-helix domain; Region: Mga; pfam05043 1046624003721 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1046624003722 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1046624003723 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1046624003724 active site 1046624003725 Na/Ca binding site [ion binding]; other site 1046624003726 catalytic site [active] 1046624003727 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1046624003728 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1046624003729 teramer interface [polypeptide binding]; other site 1046624003730 active site 1046624003731 FMN binding site [chemical binding]; other site 1046624003732 catalytic residues [active] 1046624003733 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1046624003734 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1046624003735 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1046624003736 FAD binding site [chemical binding]; other site 1046624003737 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1046624003738 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1046624003739 THF binding site; other site 1046624003740 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1046624003741 substrate binding site [chemical binding]; other site 1046624003742 THF binding site; other site 1046624003743 zinc-binding site [ion binding]; other site 1046624003744 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1046624003745 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1046624003746 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1046624003747 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1046624003748 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1046624003749 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624003750 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1046624003751 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1046624003752 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1046624003753 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1046624003754 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1046624003755 DltD N-terminal region; Region: DltD_N; pfam04915 1046624003756 DltD central region; Region: DltD_M; pfam04918 1046624003757 DltD C-terminal region; Region: DltD_C; pfam04914 1046624003758 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1046624003759 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1046624003760 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1046624003761 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1046624003762 acyl-activating enzyme (AAE) consensus motif; other site 1046624003763 AMP binding site [chemical binding]; other site 1046624003764 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1046624003765 thiamine phosphate binding site [chemical binding]; other site 1046624003766 active site 1046624003767 pyrophosphate binding site [ion binding]; other site 1046624003768 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1046624003769 substrate binding site [chemical binding]; other site 1046624003770 dimer interface [polypeptide binding]; other site 1046624003771 ATP binding site [chemical binding]; other site 1046624003772 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1046624003773 substrate binding site [chemical binding]; other site 1046624003774 multimerization interface [polypeptide binding]; other site 1046624003775 ATP binding site [chemical binding]; other site 1046624003776 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1046624003777 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 1046624003778 DXD motif; other site 1046624003779 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1046624003780 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1046624003781 active site 1046624003782 homodimer interface [polypeptide binding]; other site 1046624003783 LytTr DNA-binding domain; Region: LytTR; smart00850 1046624003784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624003785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624003786 non-specific DNA binding site [nucleotide binding]; other site 1046624003787 salt bridge; other site 1046624003788 sequence-specific DNA binding site [nucleotide binding]; other site 1046624003789 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1046624003790 core dimer interface [polypeptide binding]; other site 1046624003791 peripheral dimer interface [polypeptide binding]; other site 1046624003792 L10 interface [polypeptide binding]; other site 1046624003793 L11 interface [polypeptide binding]; other site 1046624003794 putative EF-Tu interaction site [polypeptide binding]; other site 1046624003795 putative EF-G interaction site [polypeptide binding]; other site 1046624003796 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1046624003797 23S rRNA interface [nucleotide binding]; other site 1046624003798 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1046624003799 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624003800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624003801 non-specific DNA binding site [nucleotide binding]; other site 1046624003802 salt bridge; other site 1046624003803 sequence-specific DNA binding site [nucleotide binding]; other site 1046624003804 Predicted transcriptional regulator [Transcription]; Region: COG2932 1046624003805 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1046624003806 Catalytic site [active] 1046624003807 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624003808 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624003809 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1046624003810 Walker A/P-loop; other site 1046624003811 ATP binding site [chemical binding]; other site 1046624003812 Q-loop/lid; other site 1046624003813 ABC transporter signature motif; other site 1046624003814 Walker B; other site 1046624003815 D-loop; other site 1046624003816 H-loop/switch region; other site 1046624003817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624003818 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1046624003819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624003820 Walker A/P-loop; other site 1046624003821 ATP binding site [chemical binding]; other site 1046624003822 Q-loop/lid; other site 1046624003823 ABC transporter signature motif; other site 1046624003824 Walker B; other site 1046624003825 D-loop; other site 1046624003826 H-loop/switch region; other site 1046624003827 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1046624003828 Predicted membrane protein [Function unknown]; Region: COG3601 1046624003829 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1046624003830 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1046624003831 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624003832 RNA binding surface [nucleotide binding]; other site 1046624003833 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1046624003834 active site 1046624003835 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1046624003836 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1046624003837 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1046624003838 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1046624003839 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1046624003840 DNA binding site [nucleotide binding] 1046624003841 FOG: CBS domain [General function prediction only]; Region: COG0517 1046624003842 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1046624003843 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1046624003844 active site 1046624003845 metal binding site [ion binding]; metal-binding site 1046624003846 homotetramer interface [polypeptide binding]; other site 1046624003847 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1046624003848 active site 1046624003849 dimerization interface [polypeptide binding]; other site 1046624003850 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 1046624003851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1046624003852 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1046624003853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1046624003854 active site 1046624003855 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1046624003856 substrate binding site [chemical binding]; other site 1046624003857 catalytic residues [active] 1046624003858 dimer interface [polypeptide binding]; other site 1046624003859 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1046624003860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1046624003861 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1046624003862 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1046624003863 active site 1046624003864 dimer interface [polypeptide binding]; other site 1046624003865 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1046624003866 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1046624003867 active site 1046624003868 FMN binding site [chemical binding]; other site 1046624003869 substrate binding site [chemical binding]; other site 1046624003870 3Fe-4S cluster binding site [ion binding]; other site 1046624003871 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1046624003872 domain interface; other site 1046624003873 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1046624003874 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1046624003875 active site 1046624003876 substrate binding site [chemical binding]; other site 1046624003877 trimer interface [polypeptide binding]; other site 1046624003878 CoA binding site [chemical binding]; other site 1046624003879 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1046624003880 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1046624003881 homodimer interface [polypeptide binding]; other site 1046624003882 substrate-cofactor binding pocket; other site 1046624003883 catalytic residue [active] 1046624003884 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1046624003885 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1046624003886 K01580 glutamate decarboxylase 1046624003887 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1046624003888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624003889 non-specific DNA binding site [nucleotide binding]; other site 1046624003890 salt bridge; other site 1046624003891 sequence-specific DNA binding site [nucleotide binding]; other site 1046624003892 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624003893 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1046624003894 RNA/DNA hybrid binding site [nucleotide binding]; other site 1046624003895 active site 1046624003896 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1046624003897 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1046624003898 GTP/Mg2+ binding site [chemical binding]; other site 1046624003899 G4 box; other site 1046624003900 G5 box; other site 1046624003901 G1 box; other site 1046624003902 Switch I region; other site 1046624003903 G2 box; other site 1046624003904 G3 box; other site 1046624003905 Switch II region; other site 1046624003906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1046624003907 Coenzyme A binding pocket [chemical binding]; other site 1046624003908 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1046624003909 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1046624003910 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1046624003911 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1046624003912 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1046624003913 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1046624003914 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1046624003915 active site 1046624003916 Predicted membrane protein [Function unknown]; Region: COG3152 1046624003917 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1046624003918 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003919 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003920 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624003921 metal ABC transporter substrate binding protein; may contain frameshift 1046624003922 Cell division protein FtsQ; Region: FtsQ; pfam03799 1046624003923 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 1046624003924 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1046624003925 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1046624003926 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1046624003927 NodB motif; other site 1046624003928 active site 1046624003929 catalytic site [active] 1046624003930 metal binding site [ion binding]; metal-binding site 1046624003931 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1046624003932 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1046624003933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624003934 dimer interface [polypeptide binding]; other site 1046624003935 conserved gate region; other site 1046624003936 putative PBP binding loops; other site 1046624003937 ABC-ATPase subunit interface; other site 1046624003938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624003939 dimer interface [polypeptide binding]; other site 1046624003940 conserved gate region; other site 1046624003941 putative PBP binding loops; other site 1046624003942 ABC-ATPase subunit interface; other site 1046624003943 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1046624003944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1046624003945 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1046624003946 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1046624003947 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1046624003948 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1046624003949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1046624003950 transmembrane helices; other site 1046624003951 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1046624003952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624003953 catalytic core [active] 1046624003954 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1046624003955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003956 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1046624003957 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624003958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624003959 maltose O-acetyltransferase; Provisional; Region: PRK10092 1046624003960 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1046624003961 active site 1046624003962 substrate binding site [chemical binding]; other site 1046624003963 trimer interface [polypeptide binding]; other site 1046624003964 CoA binding site [chemical binding]; other site 1046624003965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1046624003966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624003967 active site 1046624003968 metal binding site [ion binding]; metal-binding site 1046624003969 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1046624003970 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1046624003971 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1046624003972 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1046624003973 dimer interface [polypeptide binding]; other site 1046624003974 PYR/PP interface [polypeptide binding]; other site 1046624003975 TPP binding site [chemical binding]; other site 1046624003976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1046624003977 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1046624003978 TPP-binding site [chemical binding]; other site 1046624003979 dimer interface [polypeptide binding]; other site 1046624003980 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624003981 MarR family; Region: MarR_2; pfam12802 1046624003982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624003983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624003984 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1046624003985 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1046624003986 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1046624003987 short chain dehydrogenase; Validated; Region: PRK06182 1046624003988 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1046624003989 NADP binding site [chemical binding]; other site 1046624003990 active site 1046624003991 steroid binding site; other site 1046624003992 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1046624003993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1046624003994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1046624003995 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1046624003996 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1046624003997 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1046624003998 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1046624003999 active site 1046624004000 P-loop; other site 1046624004001 phosphorylation site [posttranslational modification] 1046624004002 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1046624004003 intersubunit interface [polypeptide binding]; other site 1046624004004 active site 1046624004005 zinc binding site [ion binding]; other site 1046624004006 Na+ binding site [ion binding]; other site 1046624004007 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1046624004008 PRD domain; Region: PRD; pfam00874 1046624004009 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1046624004010 active site 1046624004011 P-loop; other site 1046624004012 phosphorylation site [posttranslational modification] 1046624004013 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1046624004014 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1046624004015 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1046624004016 ArsC family; Region: ArsC; pfam03960 1046624004017 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1046624004018 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1046624004019 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1046624004020 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1046624004021 substrate-cofactor binding pocket; other site 1046624004022 homodimer interface [polypeptide binding]; other site 1046624004023 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1046624004024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624004025 catalytic residue [active] 1046624004026 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1046624004027 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1046624004028 glutamine binding [chemical binding]; other site 1046624004029 catalytic triad [active] 1046624004030 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1046624004031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624004032 non-specific DNA binding site [nucleotide binding]; other site 1046624004033 salt bridge; other site 1046624004034 sequence-specific DNA binding site [nucleotide binding]; other site 1046624004035 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1046624004036 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1046624004037 metal binding site [ion binding]; metal-binding site 1046624004038 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1046624004039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1046624004040 ABC-ATPase subunit interface; other site 1046624004041 dimer interface [polypeptide binding]; other site 1046624004042 putative PBP binding regions; other site 1046624004043 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1046624004044 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1046624004045 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1046624004046 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1046624004047 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1046624004048 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1046624004049 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1046624004050 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1046624004051 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1046624004052 Walker A/P-loop; other site 1046624004053 ATP binding site [chemical binding]; other site 1046624004054 Q-loop/lid; other site 1046624004055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624004056 ABC transporter signature motif; other site 1046624004057 Walker B; other site 1046624004058 D-loop; other site 1046624004059 H-loop/switch region; other site 1046624004060 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1046624004061 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1046624004062 active site 1046624004063 metal binding site [ion binding]; metal-binding site 1046624004064 DNA binding site [nucleotide binding] 1046624004065 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1046624004066 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1046624004067 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1046624004068 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1046624004069 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1046624004070 ArsC family; Region: ArsC; pfam03960 1046624004071 putative catalytic residues [active] 1046624004072 thiol/disulfide switch; other site 1046624004073 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1046624004074 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1046624004075 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1046624004076 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1046624004077 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 1046624004078 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1046624004079 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1046624004080 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1046624004081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624004082 S-adenosylmethionine binding site [chemical binding]; other site 1046624004083 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1046624004084 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1046624004085 Walker A/P-loop; other site 1046624004086 ATP binding site [chemical binding]; other site 1046624004087 Q-loop/lid; other site 1046624004088 ABC transporter signature motif; other site 1046624004089 Walker B; other site 1046624004090 D-loop; other site 1046624004091 H-loop/switch region; other site 1046624004092 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1046624004093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1046624004094 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1046624004095 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1046624004096 TM-ABC transporter signature motif; other site 1046624004097 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1046624004098 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1046624004099 TM-ABC transporter signature motif; other site 1046624004100 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1046624004101 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1046624004102 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624004103 NAD binding site [chemical binding]; other site 1046624004104 dimer interface [polypeptide binding]; other site 1046624004105 substrate binding site [chemical binding]; other site 1046624004106 pyruvate kinase; Provisional; Region: PRK05826 1046624004107 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1046624004108 domain interfaces; other site 1046624004109 active site 1046624004110 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1046624004111 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1046624004112 active site 1046624004113 ADP/pyrophosphate binding site [chemical binding]; other site 1046624004114 dimerization interface [polypeptide binding]; other site 1046624004115 allosteric effector site; other site 1046624004116 fructose-1,6-bisphosphate binding site; other site 1046624004117 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1046624004118 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1046624004119 active site 1046624004120 dimer interface [polypeptide binding]; other site 1046624004121 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1046624004122 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1046624004123 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1046624004124 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1046624004125 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1046624004126 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1046624004127 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1046624004128 active site 1046624004129 tetramer interface; other site 1046624004130 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1046624004131 trimer interface [polypeptide binding]; other site 1046624004132 Predicted membrane protein [Function unknown]; Region: COG4769 1046624004133 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1046624004134 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1046624004135 substrate binding pocket [chemical binding]; other site 1046624004136 chain length determination region; other site 1046624004137 substrate-Mg2+ binding site; other site 1046624004138 catalytic residues [active] 1046624004139 aspartate-rich region 1; other site 1046624004140 active site lid residues [active] 1046624004141 aspartate-rich region 2; other site 1046624004142 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1046624004143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624004144 S-adenosylmethionine binding site [chemical binding]; other site 1046624004145 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1046624004146 active site 1046624004147 dimer interface [polypeptide binding]; other site 1046624004148 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1046624004149 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1046624004150 heterodimer interface [polypeptide binding]; other site 1046624004151 active site 1046624004152 FMN binding site [chemical binding]; other site 1046624004153 homodimer interface [polypeptide binding]; other site 1046624004154 substrate binding site [chemical binding]; other site 1046624004155 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1046624004156 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1046624004157 FAD binding pocket [chemical binding]; other site 1046624004158 FAD binding motif [chemical binding]; other site 1046624004159 phosphate binding motif [ion binding]; other site 1046624004160 beta-alpha-beta structure motif; other site 1046624004161 NAD binding pocket [chemical binding]; other site 1046624004162 Iron coordination center [ion binding]; other site 1046624004163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624004165 putative substrate translocation pore; other site 1046624004166 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1046624004167 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1046624004168 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1046624004169 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1046624004170 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1046624004171 Repair protein; Region: Repair_PSII; pfam04536 1046624004172 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1046624004173 pseudouridine synthase; Region: TIGR00093 1046624004174 active site 1046624004175 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1046624004176 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1046624004177 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624004178 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1046624004179 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1046624004180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1046624004181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1046624004182 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1046624004183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1046624004184 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1046624004185 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1046624004186 IMP binding site; other site 1046624004187 dimer interface [polypeptide binding]; other site 1046624004188 interdomain contacts; other site 1046624004189 partial ornithine binding site; other site 1046624004190 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1046624004191 catalytic residues [active] 1046624004192 dimer interface [polypeptide binding]; other site 1046624004193 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1046624004194 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1046624004195 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1046624004196 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624004197 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1046624004198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624004199 motif II; other site 1046624004200 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1046624004201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1046624004202 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1046624004203 TraX protein; Region: TraX; cl05434 1046624004204 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1046624004205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624004206 Ligand Binding Site [chemical binding]; other site 1046624004207 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1046624004208 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1046624004209 active site 1046624004210 putative DNA-binding protein; Validated; Region: PRK00118 1046624004211 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1046624004212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624004213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624004214 active site 1046624004215 phosphorylation site [posttranslational modification] 1046624004216 intermolecular recognition site; other site 1046624004217 dimerization interface [polypeptide binding]; other site 1046624004218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624004219 DNA binding site [nucleotide binding] 1046624004220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624004221 dimer interface [polypeptide binding]; other site 1046624004222 phosphorylation site [posttranslational modification] 1046624004223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624004224 ATP binding site [chemical binding]; other site 1046624004225 Mg2+ binding site [ion binding]; other site 1046624004226 G-X-G motif; other site 1046624004227 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1046624004228 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1046624004229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1046624004230 DNA-binding site [nucleotide binding]; DNA binding site 1046624004231 UTRA domain; Region: UTRA; pfam07702 1046624004232 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1046624004233 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1046624004234 ligand binding site [chemical binding]; other site 1046624004235 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1046624004236 active site 1046624004237 catalytic motif [active] 1046624004238 Zn binding site [ion binding]; other site 1046624004239 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1046624004240 intersubunit interface [polypeptide binding]; other site 1046624004241 active site 1046624004242 catalytic residue [active] 1046624004243 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1046624004244 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1046624004245 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1046624004246 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1046624004247 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1046624004248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624004249 S-adenosylmethionine binding site [chemical binding]; other site 1046624004250 pantothenate kinase; Provisional; Region: PRK05439 1046624004251 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1046624004252 ATP-binding site [chemical binding]; other site 1046624004253 CoA-binding site [chemical binding]; other site 1046624004254 Mg2+-binding site [ion binding]; other site 1046624004255 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1046624004256 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1046624004257 Cation efflux family; Region: Cation_efflux; pfam01545 1046624004258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624004259 non-specific DNA binding site [nucleotide binding]; other site 1046624004260 salt bridge; other site 1046624004261 sequence-specific DNA binding site [nucleotide binding]; other site 1046624004262 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1046624004263 ParB-like nuclease domain; Region: ParBc; pfam02195 1046624004264 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1046624004265 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1046624004266 Active Sites [active] 1046624004267 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1046624004268 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1046624004269 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1046624004270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624004271 dimer interface [polypeptide binding]; other site 1046624004272 conserved gate region; other site 1046624004273 putative PBP binding loops; other site 1046624004274 ABC-ATPase subunit interface; other site 1046624004275 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1046624004276 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1046624004277 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1046624004278 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1046624004279 Walker A/P-loop; other site 1046624004280 ATP binding site [chemical binding]; other site 1046624004281 Q-loop/lid; other site 1046624004282 ABC transporter signature motif; other site 1046624004283 Walker B; other site 1046624004284 D-loop; other site 1046624004285 H-loop/switch region; other site 1046624004286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1046624004287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1046624004288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1046624004289 DNA-binding site [nucleotide binding]; DNA binding site 1046624004290 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1046624004291 TrkA-C domain; Region: TrkA_C; pfam02080 1046624004292 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1046624004293 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1046624004294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1046624004295 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1046624004296 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1046624004297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1046624004298 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1046624004299 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1046624004300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1046624004301 active site 1046624004302 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1046624004303 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1046624004304 beta-galactosidase; Region: BGL; TIGR03356 1046624004305 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1046624004306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1046624004307 active site turn [active] 1046624004308 phosphorylation site [posttranslational modification] 1046624004309 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1046624004310 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1046624004311 HPr interaction site; other site 1046624004312 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1046624004313 active site 1046624004314 phosphorylation site [posttranslational modification] 1046624004315 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1046624004316 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1046624004317 PRD domain; Region: PRD; pfam00874 1046624004318 PRD domain; Region: PRD; pfam00874 1046624004319 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1046624004320 substrate binding site [chemical binding]; other site 1046624004321 active site 1046624004322 catalytic residues [active] 1046624004323 heterodimer interface [polypeptide binding]; other site 1046624004324 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1046624004325 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1046624004326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624004327 catalytic residue [active] 1046624004328 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1046624004329 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1046624004330 active site 1046624004331 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1046624004332 active site 1046624004333 ribulose/triose binding site [chemical binding]; other site 1046624004334 phosphate binding site [ion binding]; other site 1046624004335 substrate (anthranilate) binding pocket [chemical binding]; other site 1046624004336 product (indole) binding pocket [chemical binding]; other site 1046624004337 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1046624004338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1046624004339 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1046624004340 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1046624004341 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1046624004342 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1046624004343 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1046624004344 glutamine binding [chemical binding]; other site 1046624004345 catalytic triad [active] 1046624004346 anthranilate synthase component I; Provisional; Region: PRK13570 1046624004347 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1046624004348 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1046624004349 Predicted membrane protein [Function unknown]; Region: COG3759 1046624004350 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1046624004351 dimer interface [polypeptide binding]; other site 1046624004352 FMN binding site [chemical binding]; other site 1046624004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624004354 S-adenosylmethionine binding site [chemical binding]; other site 1046624004355 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1046624004356 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1046624004357 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1046624004358 metal binding site 2 [ion binding]; metal-binding site 1046624004359 putative DNA binding helix; other site 1046624004360 metal binding site 1 [ion binding]; metal-binding site 1046624004361 dimer interface [polypeptide binding]; other site 1046624004362 structural Zn2+ binding site [ion binding]; other site 1046624004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1046624004364 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1046624004365 EamA-like transporter family; Region: EamA; pfam00892 1046624004366 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1046624004367 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1046624004368 DNA binding residues [nucleotide binding] 1046624004369 putative dimer interface [polypeptide binding]; other site 1046624004370 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1046624004371 classical (c) SDRs; Region: SDR_c; cd05233 1046624004372 NAD(P) binding site [chemical binding]; other site 1046624004373 active site 1046624004374 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1046624004375 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1046624004376 TPP-binding site; other site 1046624004377 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1046624004378 PYR/PP interface [polypeptide binding]; other site 1046624004379 dimer interface [polypeptide binding]; other site 1046624004380 TPP binding site [chemical binding]; other site 1046624004381 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1046624004382 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624004383 MarR family; Region: MarR; pfam01047 1046624004384 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1046624004385 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1046624004386 Cl binding site [ion binding]; other site 1046624004387 oligomer interface [polypeptide binding]; other site 1046624004388 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1046624004389 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1046624004390 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1046624004391 GMP synthase; Reviewed; Region: guaA; PRK00074 1046624004392 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1046624004393 AMP/PPi binding site [chemical binding]; other site 1046624004394 candidate oxyanion hole; other site 1046624004395 catalytic triad [active] 1046624004396 potential glutamine specificity residues [chemical binding]; other site 1046624004397 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1046624004398 ATP Binding subdomain [chemical binding]; other site 1046624004399 Dimerization subdomain; other site 1046624004400 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1046624004401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624004402 nucleotide binding site [chemical binding]; other site 1046624004403 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1046624004404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624004405 nucleotide binding site [chemical binding]; other site 1046624004406 butyrate kinase; Provisional; Region: PRK03011 1046624004407 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1046624004408 beta-galactosidase; Region: BGL; TIGR03356 1046624004409 Predicted integral membrane protein [Function unknown]; Region: COG5578 1046624004410 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1046624004411 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 1046624004412 putative active site [active] 1046624004413 FOG: PKD repeat [General function prediction only]; Region: COG3291 1046624004414 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1046624004415 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1046624004416 sugar binding site [chemical binding]; other site 1046624004417 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1046624004418 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1046624004419 Ca binding site [ion binding]; other site 1046624004420 active site 1046624004421 catalytic site [active] 1046624004422 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 1046624004423 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1046624004424 active site 1046624004425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1046624004426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1046624004427 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1046624004428 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1046624004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624004430 dimer interface [polypeptide binding]; other site 1046624004431 conserved gate region; other site 1046624004432 putative PBP binding loops; other site 1046624004433 ABC-ATPase subunit interface; other site 1046624004434 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1046624004435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624004436 dimer interface [polypeptide binding]; other site 1046624004437 conserved gate region; other site 1046624004438 putative PBP binding loops; other site 1046624004439 ABC-ATPase subunit interface; other site 1046624004440 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1046624004441 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1046624004442 active site 1046624004443 metal binding site [ion binding]; metal-binding site 1046624004444 homodimer interface [polypeptide binding]; other site 1046624004445 catalytic site [active] 1046624004446 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1046624004447 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1046624004448 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1046624004449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1046624004450 DNA-binding site [nucleotide binding]; DNA binding site 1046624004451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624004452 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1046624004453 ligand binding site [chemical binding]; other site 1046624004454 dimerization interface [polypeptide binding]; other site 1046624004455 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1046624004456 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1046624004457 putative phosphoketolase; Provisional; Region: PRK05261 1046624004458 XFP N-terminal domain; Region: XFP_N; pfam09364 1046624004459 XFP C-terminal domain; Region: XFP_C; pfam09363 1046624004460 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1046624004461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004462 putative substrate translocation pore; other site 1046624004463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004464 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1046624004465 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1046624004466 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1046624004467 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1046624004468 putative trimer interface [polypeptide binding]; other site 1046624004469 putative CoA binding site [chemical binding]; other site 1046624004470 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1046624004471 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1046624004472 inhibitor binding site; inhibition site 1046624004473 active site 1046624004474 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1046624004475 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1046624004476 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1046624004477 active site 1046624004478 catalytic residues [active] 1046624004479 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1046624004480 N- and C-terminal domain interface [polypeptide binding]; other site 1046624004481 D-xylulose kinase; Region: XylB; TIGR01312 1046624004482 active site 1046624004483 MgATP binding site [chemical binding]; other site 1046624004484 catalytic site [active] 1046624004485 metal binding site [ion binding]; metal-binding site 1046624004486 xylulose binding site [chemical binding]; other site 1046624004487 homodimer interface [polypeptide binding]; other site 1046624004488 xylose isomerase; Provisional; Region: PRK05474 1046624004489 xylose isomerase; Region: xylose_isom_A; TIGR02630 1046624004490 Cupin domain; Region: Cupin_2; pfam07883 1046624004491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1046624004492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1046624004493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1046624004494 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1046624004495 ATP-grasp domain; Region: ATP-grasp; pfam02222 1046624004496 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1046624004497 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1046624004498 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1046624004499 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1046624004500 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1046624004501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624004502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624004503 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1046624004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624004506 putative substrate translocation pore; other site 1046624004507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624004509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004510 putative substrate translocation pore; other site 1046624004511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004512 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1046624004513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624004514 motif II; other site 1046624004515 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1046624004516 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1046624004517 purine monophosphate binding site [chemical binding]; other site 1046624004518 dimer interface [polypeptide binding]; other site 1046624004519 putative catalytic residues [active] 1046624004520 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1046624004521 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1046624004522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624004523 active site 1046624004524 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1046624004525 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1046624004526 NADP binding site [chemical binding]; other site 1046624004527 putative substrate binding site [chemical binding]; other site 1046624004528 active site 1046624004529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624004530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624004531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1046624004532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1046624004533 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1046624004534 Walker A/P-loop; other site 1046624004535 ATP binding site [chemical binding]; other site 1046624004536 Q-loop/lid; other site 1046624004537 ABC transporter signature motif; other site 1046624004538 Walker B; other site 1046624004539 D-loop; other site 1046624004540 H-loop/switch region; other site 1046624004541 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1046624004542 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1046624004543 active site 1046624004544 substrate binding site [chemical binding]; other site 1046624004545 cosubstrate binding site; other site 1046624004546 catalytic site [active] 1046624004547 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1046624004548 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1046624004549 dimerization interface [polypeptide binding]; other site 1046624004550 putative ATP binding site [chemical binding]; other site 1046624004551 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1046624004552 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1046624004553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624004554 ATP binding site [chemical binding]; other site 1046624004555 putative Mg++ binding site [ion binding]; other site 1046624004556 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624004557 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1046624004558 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1046624004559 SEC-C motif; Region: SEC-C; pfam02810 1046624004560 Fic family protein [Function unknown]; Region: COG3177 1046624004561 Fic/DOC family; Region: Fic; pfam02661 1046624004562 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1046624004563 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1046624004564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624004565 S-adenosylmethionine binding site [chemical binding]; other site 1046624004566 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1046624004567 Clp amino terminal domain; Region: Clp_N; pfam02861 1046624004568 Clp amino terminal domain; Region: Clp_N; pfam02861 1046624004569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624004570 Walker A motif; other site 1046624004571 ATP binding site [chemical binding]; other site 1046624004572 Walker B motif; other site 1046624004573 arginine finger; other site 1046624004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624004575 Walker A motif; other site 1046624004576 ATP binding site [chemical binding]; other site 1046624004577 Walker B motif; other site 1046624004578 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1046624004579 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1046624004580 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1046624004581 active site 1046624004582 tetramer interface [polypeptide binding]; other site 1046624004583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624004584 active site 1046624004585 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1046624004586 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1046624004587 dimerization interface [polypeptide binding]; other site 1046624004588 ATP binding site [chemical binding]; other site 1046624004589 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1046624004590 dimerization interface [polypeptide binding]; other site 1046624004591 ATP binding site [chemical binding]; other site 1046624004592 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1046624004593 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1046624004594 putative active site [active] 1046624004595 catalytic triad [active] 1046624004596 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1046624004597 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1046624004598 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1046624004599 ATP binding site [chemical binding]; other site 1046624004600 active site 1046624004601 substrate binding site [chemical binding]; other site 1046624004602 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1046624004603 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1046624004604 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1046624004605 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1046624004606 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1046624004607 classical (c) SDRs; Region: SDR_c; cd05233 1046624004608 NAD(P) binding site [chemical binding]; other site 1046624004609 active site 1046624004610 putative transporter; Provisional; Region: PRK10504 1046624004611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004612 putative substrate translocation pore; other site 1046624004613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004614 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624004615 MarR family; Region: MarR_2; pfam12802 1046624004616 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1046624004617 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1046624004618 dimerization interface [polypeptide binding]; other site 1046624004619 active site 1046624004620 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1046624004621 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1046624004622 catalytic Zn binding site [ion binding]; other site 1046624004623 NAD(P) binding site [chemical binding]; other site 1046624004624 structural Zn binding site [ion binding]; other site 1046624004625 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1046624004626 Predicted membrane protein [Function unknown]; Region: COG4905 1046624004627 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1046624004628 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1046624004629 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1046624004630 active site 1046624004631 FMN binding site [chemical binding]; other site 1046624004632 substrate binding site [chemical binding]; other site 1046624004633 catalytic residues [active] 1046624004634 homodimer interface [polypeptide binding]; other site 1046624004635 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1046624004636 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1046624004637 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1046624004638 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1046624004639 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1046624004640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624004641 Walker A/P-loop; other site 1046624004642 ATP binding site [chemical binding]; other site 1046624004643 Q-loop/lid; other site 1046624004644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624004645 ABC transporter signature motif; other site 1046624004646 Walker B; other site 1046624004647 D-loop; other site 1046624004648 ABC transporter; Region: ABC_tran_2; pfam12848 1046624004649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1046624004650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624004651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624004652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1046624004653 dimerization interface [polypeptide binding]; other site 1046624004654 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1046624004655 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1046624004656 putative active site [active] 1046624004657 metal binding site [ion binding]; metal-binding site 1046624004658 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1046624004659 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1046624004660 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1046624004661 active site 1046624004662 NTP binding site [chemical binding]; other site 1046624004663 metal binding triad [ion binding]; metal-binding site 1046624004664 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1046624004665 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1046624004666 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1046624004667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1046624004668 Coenzyme A binding pocket [chemical binding]; other site 1046624004669 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1046624004670 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1046624004671 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1046624004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1046624004673 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1046624004674 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1046624004675 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1046624004676 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1046624004677 RimM N-terminal domain; Region: RimM; pfam01782 1046624004678 PRC-barrel domain; Region: PRC; pfam05239 1046624004679 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1046624004680 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1046624004681 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1046624004682 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1046624004683 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1046624004684 C-terminal domain interface [polypeptide binding]; other site 1046624004685 active site 1046624004686 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1046624004687 active site 1046624004688 N-terminal domain interface [polypeptide binding]; other site 1046624004689 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1046624004690 KH domain; Region: KH_4; pfam13083 1046624004691 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1046624004692 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1046624004693 homodimer interface [polypeptide binding]; other site 1046624004694 catalytic residues [active] 1046624004695 NAD binding site [chemical binding]; other site 1046624004696 substrate binding pocket [chemical binding]; other site 1046624004697 flexible flap; other site 1046624004698 putative acyltransferase; Provisional; Region: PRK05790 1046624004699 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1046624004700 dimer interface [polypeptide binding]; other site 1046624004701 active site 1046624004702 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1046624004703 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1046624004704 dimer interface [polypeptide binding]; other site 1046624004705 active site 1046624004706 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1046624004707 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1046624004708 active site 1046624004709 trimer interface [polypeptide binding]; other site 1046624004710 allosteric site; other site 1046624004711 active site lid [active] 1046624004712 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1046624004713 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1046624004714 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1046624004715 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1046624004716 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1046624004717 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1046624004718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624004719 non-specific DNA binding site [nucleotide binding]; other site 1046624004720 salt bridge; other site 1046624004721 sequence-specific DNA binding site [nucleotide binding]; other site 1046624004722 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1046624004723 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1046624004724 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624004725 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624004726 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624004727 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1046624004728 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1046624004729 GTP1/OBG; Region: GTP1_OBG; pfam01018 1046624004730 Obg GTPase; Region: Obg; cd01898 1046624004731 G1 box; other site 1046624004732 GTP/Mg2+ binding site [chemical binding]; other site 1046624004733 Switch I region; other site 1046624004734 G2 box; other site 1046624004735 G3 box; other site 1046624004736 Switch II region; other site 1046624004737 G4 box; other site 1046624004738 G5 box; other site 1046624004739 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1046624004740 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1046624004741 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1046624004742 Cell division protein FtsQ; Region: FtsQ; pfam03799 1046624004743 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1046624004744 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1046624004745 homodimer interface [polypeptide binding]; other site 1046624004746 active site 1046624004747 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1046624004748 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1046624004749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624004750 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1046624004751 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1046624004752 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1046624004753 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1046624004754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624004755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1046624004756 dimerization interface [polypeptide binding]; other site 1046624004757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624004758 dimer interface [polypeptide binding]; other site 1046624004759 phosphorylation site [posttranslational modification] 1046624004760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624004761 ATP binding site [chemical binding]; other site 1046624004762 Mg2+ binding site [ion binding]; other site 1046624004763 G-X-G motif; other site 1046624004764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624004765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624004766 active site 1046624004767 phosphorylation site [posttranslational modification] 1046624004768 intermolecular recognition site; other site 1046624004769 dimerization interface [polypeptide binding]; other site 1046624004770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624004771 DNA binding site [nucleotide binding] 1046624004772 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1046624004773 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1046624004774 conserved hypothetical protein; Region: TIGR02328 1046624004775 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1046624004776 CHAP domain; Region: CHAP; pfam05257 1046624004777 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1046624004778 phosphodiesterase YaeI; Provisional; Region: PRK11340 1046624004779 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1046624004780 putative active site [active] 1046624004781 putative metal binding site [ion binding]; other site 1046624004782 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1046624004783 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1046624004784 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1046624004785 catalytic site [active] 1046624004786 subunit interface [polypeptide binding]; other site 1046624004787 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1046624004788 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1046624004789 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1046624004790 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1046624004791 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1046624004792 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624004793 active site 1046624004794 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1046624004795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624004796 dimerization interface [polypeptide binding]; other site 1046624004797 putative DNA binding site [nucleotide binding]; other site 1046624004798 putative Zn2+ binding site [ion binding]; other site 1046624004799 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1046624004800 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1046624004801 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1046624004802 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1046624004803 putative catalytic cysteine [active] 1046624004804 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1046624004805 nucleotide binding site [chemical binding]; other site 1046624004806 homotetrameric interface [polypeptide binding]; other site 1046624004807 putative phosphate binding site [ion binding]; other site 1046624004808 putative allosteric binding site; other site 1046624004809 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1046624004810 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1046624004811 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1046624004812 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1046624004813 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1046624004814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624004815 Coenzyme A binding pocket [chemical binding]; other site 1046624004816 signal recognition particle protein; Provisional; Region: PRK10867 1046624004817 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1046624004818 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1046624004819 P loop; other site 1046624004820 GTP binding site [chemical binding]; other site 1046624004821 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1046624004822 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1046624004823 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1046624004824 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1046624004825 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1046624004826 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1046624004827 MgtC family; Region: MgtC; pfam02308 1046624004828 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1046624004829 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1046624004830 dimer interface [polypeptide binding]; other site 1046624004831 active site 1046624004832 catalytic residue [active] 1046624004833 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1046624004834 nudix motif; other site 1046624004835 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1046624004836 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1046624004837 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1046624004838 amphipathic channel; other site 1046624004839 Asn-Pro-Ala signature motifs; other site 1046624004840 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1046624004841 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1046624004842 TPP-binding site [chemical binding]; other site 1046624004843 dimer interface [polypeptide binding]; other site 1046624004844 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1046624004845 PYR/PP interface [polypeptide binding]; other site 1046624004846 dimer interface [polypeptide binding]; other site 1046624004847 TPP binding site [chemical binding]; other site 1046624004848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1046624004849 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1046624004850 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1046624004851 PRD domain; Region: PRD; pfam00874 1046624004852 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1046624004853 active site 1046624004854 P-loop; other site 1046624004855 phosphorylation site [posttranslational modification] 1046624004856 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1046624004857 active site 1046624004858 phosphorylation site [posttranslational modification] 1046624004859 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1046624004860 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1046624004861 active site 1046624004862 intersubunit interface [polypeptide binding]; other site 1046624004863 catalytic residue [active] 1046624004864 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1046624004865 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1046624004866 substrate binding site [chemical binding]; other site 1046624004867 ATP binding site [chemical binding]; other site 1046624004868 Glucuronate isomerase; Region: UxaC; pfam02614 1046624004869 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1046624004870 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1046624004871 active site 1046624004872 catalytic residues [active] 1046624004873 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1046624004874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004875 putative substrate translocation pore; other site 1046624004876 mannonate dehydratase; Provisional; Region: PRK03906 1046624004877 mannonate dehydratase; Region: uxuA; TIGR00695 1046624004878 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1046624004879 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1046624004880 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1046624004881 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1046624004882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1046624004883 DNA-binding site [nucleotide binding]; DNA binding site 1046624004884 FCD domain; Region: FCD; pfam07729 1046624004885 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1046624004886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624004887 putative substrate translocation pore; other site 1046624004888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1046624004889 DNA-binding site [nucleotide binding]; DNA binding site 1046624004890 RNA-binding motif; other site 1046624004891 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1046624004892 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1046624004893 active site 1046624004894 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1046624004895 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1046624004896 active site 1046624004897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624004898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624004899 Haemolysin XhlA; Region: XhlA; pfam10779 1046624004900 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cd07964 1046624004901 trimer interface [polypeptide binding]; other site 1046624004902 gp58-like protein; Region: Gp58; pfam07902 1046624004903 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1046624004904 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1046624004905 catalytic residue [active] 1046624004906 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1046624004907 Phage tail protein; Region: Phage_tail_3; pfam08813 1046624004908 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1046624004909 Phage capsid family; Region: Phage_capsid; pfam05065 1046624004910 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1046624004911 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1046624004912 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1046624004913 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1046624004914 hypothetical protein; Provisional; Region: PRK14553 1046624004915 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1046624004916 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1046624004917 Phage terminase large subunit; Region: Terminase_3; cl12054 1046624004918 Terminase-like family; Region: Terminase_6; pfam03237 1046624004919 Protein of unknown function (DUF722); Region: DUF722; pfam05263 1046624004920 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 1046624004921 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1046624004922 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 1046624004923 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1046624004924 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1046624004925 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1046624004926 dimer interface [polypeptide binding]; other site 1046624004927 ssDNA binding site [nucleotide binding]; other site 1046624004928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624004929 ERF superfamily; Region: ERF; pfam04404 1046624004930 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 1046624004931 Helix-turn-helix domain; Region: HTH_17; pfam12728 1046624004932 Phage anti-repressor protein [Transcription]; Region: COG3561 1046624004933 ORF6C domain; Region: ORF6C; pfam10552 1046624004934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1046624004935 non-specific DNA binding site [nucleotide binding]; other site 1046624004936 salt bridge; other site 1046624004937 sequence-specific DNA binding site [nucleotide binding]; other site 1046624004938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624004939 non-specific DNA binding site [nucleotide binding]; other site 1046624004940 salt bridge; other site 1046624004941 sequence-specific DNA binding site [nucleotide binding]; other site 1046624004942 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 1046624004943 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 1046624004944 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 1046624004945 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1046624004946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1046624004947 active site 1046624004948 DNA binding site [nucleotide binding] 1046624004949 Int/Topo IB signature motif; other site 1046624004950 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1046624004951 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1046624004952 ligand binding site [chemical binding]; other site 1046624004953 dimerization interface [polypeptide binding]; other site 1046624004954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1046624004955 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1046624004956 TM-ABC transporter signature motif; other site 1046624004957 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1046624004958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624004959 Walker A/P-loop; other site 1046624004960 ATP binding site [chemical binding]; other site 1046624004961 Q-loop/lid; other site 1046624004962 ABC transporter signature motif; other site 1046624004963 Walker B; other site 1046624004964 D-loop; other site 1046624004965 H-loop/switch region; other site 1046624004966 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1046624004967 D-ribose pyranase; Provisional; Region: PRK11797 1046624004968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1046624004969 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1046624004970 substrate binding site [chemical binding]; other site 1046624004971 dimer interface [polypeptide binding]; other site 1046624004972 ATP binding site [chemical binding]; other site 1046624004973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624004974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624004975 DNA binding site [nucleotide binding] 1046624004976 domain linker motif; other site 1046624004977 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1046624004978 dimerization interface [polypeptide binding]; other site 1046624004979 ligand binding site [chemical binding]; other site 1046624004980 adenylosuccinate lyase; Provisional; Region: PRK07492 1046624004981 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1046624004982 tetramer interface [polypeptide binding]; other site 1046624004983 active site 1046624004984 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1046624004985 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1046624004986 active site 1046624004987 catalytic residue [active] 1046624004988 dimer interface [polypeptide binding]; other site 1046624004989 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1046624004990 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1046624004991 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1046624004992 catalytic residues [active] 1046624004993 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 1046624004994 MutS domain III; Region: MutS_III; pfam05192 1046624004995 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1046624004996 Walker A/P-loop; other site 1046624004997 ATP binding site [chemical binding]; other site 1046624004998 Q-loop/lid; other site 1046624004999 ABC transporter signature motif; other site 1046624005000 Walker B; other site 1046624005001 D-loop; other site 1046624005002 H-loop/switch region; other site 1046624005003 Smr domain; Region: Smr; pfam01713 1046624005004 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1046624005005 Colicin V production protein; Region: Colicin_V; pfam02674 1046624005006 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1046624005007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624005008 catabolite control protein A; Region: ccpA; TIGR01481 1046624005009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624005010 DNA binding site [nucleotide binding] 1046624005011 domain linker motif; other site 1046624005012 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1046624005013 dimerization interface [polypeptide binding]; other site 1046624005014 effector binding site; other site 1046624005015 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1046624005016 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1046624005017 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1046624005018 active site 1046624005019 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 1046624005020 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1046624005021 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1046624005022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1046624005023 cell division protein GpsB; Provisional; Region: PRK14127 1046624005024 DivIVA domain; Region: DivI1A_domain; TIGR03544 1046624005025 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1046624005026 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1046624005027 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1046624005028 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1046624005029 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1046624005030 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1046624005031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624005032 active site 1046624005033 motif I; other site 1046624005034 motif II; other site 1046624005035 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1046624005036 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1046624005037 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1046624005038 Sugar specificity; other site 1046624005039 Pyrimidine base specificity; other site 1046624005040 ATP-binding site [chemical binding]; other site 1046624005041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1046624005042 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1046624005043 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 1046624005044 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1046624005045 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1046624005046 UbiA prenyltransferase family; Region: UbiA; pfam01040 1046624005047 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1046624005048 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1046624005049 Cl- selectivity filter; other site 1046624005050 Cl- binding residues [ion binding]; other site 1046624005051 pore gating glutamate residue; other site 1046624005052 dimer interface [polypeptide binding]; other site 1046624005053 H+/Cl- coupling transport residue; other site 1046624005054 TrkA-C domain; Region: TrkA_C; pfam02080 1046624005055 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1046624005056 Lactococcin-like family; Region: Lactococcin; pfam04369 1046624005057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624005058 non-specific DNA binding site [nucleotide binding]; other site 1046624005059 salt bridge; other site 1046624005060 sequence-specific DNA binding site [nucleotide binding]; other site 1046624005061 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624005062 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1046624005063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624005064 S-adenosylmethionine binding site [chemical binding]; other site 1046624005065 Predicted membrane protein [Function unknown]; Region: COG1511 1046624005066 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1046624005067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1046624005068 dimer interface [polypeptide binding]; other site 1046624005069 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1046624005070 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 1046624005071 beta-galactosidase; Region: BGL; TIGR03356 1046624005072 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1046624005073 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1046624005074 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1046624005075 TPP-binding site; other site 1046624005076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1046624005077 PYR/PP interface [polypeptide binding]; other site 1046624005078 dimer interface [polypeptide binding]; other site 1046624005079 TPP binding site [chemical binding]; other site 1046624005080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1046624005081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624005082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1046624005083 dimer interface [polypeptide binding]; other site 1046624005084 phosphorylation site [posttranslational modification] 1046624005085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624005086 ATP binding site [chemical binding]; other site 1046624005087 Mg2+ binding site [ion binding]; other site 1046624005088 G-X-G motif; other site 1046624005089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624005090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624005091 active site 1046624005092 phosphorylation site [posttranslational modification] 1046624005093 intermolecular recognition site; other site 1046624005094 dimerization interface [polypeptide binding]; other site 1046624005095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624005096 DNA binding site [nucleotide binding] 1046624005097 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624005098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624005099 DNA binding site [nucleotide binding] 1046624005100 domain linker motif; other site 1046624005101 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1046624005102 putative dimerization interface [polypeptide binding]; other site 1046624005103 putative ligand binding site [chemical binding]; other site 1046624005104 maltose phosphorylase; Provisional; Region: PRK13807 1046624005105 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1046624005106 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1046624005107 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1046624005108 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1046624005109 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1046624005110 Ca binding site [ion binding]; other site 1046624005111 active site 1046624005112 catalytic site [active] 1046624005113 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1046624005114 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1046624005115 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 1046624005116 Ca binding site [ion binding]; other site 1046624005117 active site 1046624005118 catalytic site [active] 1046624005119 maltose O-acetyltransferase; Provisional; Region: PRK10092 1046624005120 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1046624005121 active site 1046624005122 substrate binding site [chemical binding]; other site 1046624005123 trimer interface [polypeptide binding]; other site 1046624005124 CoA binding site [chemical binding]; other site 1046624005125 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1046624005126 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1046624005127 Ca binding site [ion binding]; other site 1046624005128 active site 1046624005129 catalytic site [active] 1046624005130 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1046624005131 homodimer interface [polypeptide binding]; other site 1046624005132 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1046624005133 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1046624005134 active site 1046624005135 homodimer interface [polypeptide binding]; other site 1046624005136 catalytic site [active] 1046624005137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1046624005138 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1046624005139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005140 dimer interface [polypeptide binding]; other site 1046624005141 conserved gate region; other site 1046624005142 putative PBP binding loops; other site 1046624005143 ABC-ATPase subunit interface; other site 1046624005144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1046624005145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005146 dimer interface [polypeptide binding]; other site 1046624005147 conserved gate region; other site 1046624005148 putative PBP binding loops; other site 1046624005149 ABC-ATPase subunit interface; other site 1046624005150 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1046624005151 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1046624005152 LssY C-terminus; Region: LssY_C; pfam14067 1046624005153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624005154 dimerization interface [polypeptide binding]; other site 1046624005155 putative DNA binding site [nucleotide binding]; other site 1046624005156 putative Zn2+ binding site [ion binding]; other site 1046624005157 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1046624005158 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1046624005159 putative active site [active] 1046624005160 putative FMN binding site [chemical binding]; other site 1046624005161 putative substrate binding site [chemical binding]; other site 1046624005162 putative catalytic residue [active] 1046624005163 carbamate kinase; Reviewed; Region: PRK12686 1046624005164 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1046624005165 putative substrate binding site [chemical binding]; other site 1046624005166 nucleotide binding site [chemical binding]; other site 1046624005167 nucleotide binding site [chemical binding]; other site 1046624005168 homodimer interface [polypeptide binding]; other site 1046624005169 agmatine deiminase; Provisional; Region: PRK13551 1046624005170 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1046624005171 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1046624005172 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1046624005173 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1046624005174 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1046624005175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1046624005176 DNA binding residues [nucleotide binding] 1046624005177 dimerization interface [polypeptide binding]; other site 1046624005178 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1046624005179 cytidylate kinase; Provisional; Region: cmk; PRK00023 1046624005180 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1046624005181 CMP-binding site; other site 1046624005182 The sites determining sugar specificity; other site 1046624005183 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1046624005184 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1046624005185 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1046624005186 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1046624005187 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1046624005188 active pocket/dimerization site; other site 1046624005189 active site 1046624005190 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1046624005191 active site 1046624005192 phosphorylation site [posttranslational modification] 1046624005193 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1046624005194 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1046624005195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 1046624005196 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1046624005197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 1046624005198 seryl-tRNA synthetase; Provisional; Region: PRK05431 1046624005199 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1046624005200 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1046624005201 dimer interface [polypeptide binding]; other site 1046624005202 active site 1046624005203 motif 1; other site 1046624005204 motif 2; other site 1046624005205 motif 3; other site 1046624005206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1046624005207 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1046624005208 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1046624005209 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1046624005210 Walker A/P-loop; other site 1046624005211 ATP binding site [chemical binding]; other site 1046624005212 Q-loop/lid; other site 1046624005213 ABC transporter signature motif; other site 1046624005214 Walker B; other site 1046624005215 D-loop; other site 1046624005216 H-loop/switch region; other site 1046624005217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624005218 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1046624005219 FeS/SAM binding site; other site 1046624005220 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1046624005221 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1046624005222 putative dimer interface [polypeptide binding]; other site 1046624005223 catalytic triad [active] 1046624005224 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624005225 catalytic core [active] 1046624005226 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1046624005227 PhoU domain; Region: PhoU; pfam01895 1046624005228 PhoU domain; Region: PhoU; pfam01895 1046624005229 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1046624005230 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1046624005231 Walker A/P-loop; other site 1046624005232 ATP binding site [chemical binding]; other site 1046624005233 Q-loop/lid; other site 1046624005234 ABC transporter signature motif; other site 1046624005235 Walker B; other site 1046624005236 D-loop; other site 1046624005237 H-loop/switch region; other site 1046624005238 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1046624005239 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1046624005240 Walker A/P-loop; other site 1046624005241 ATP binding site [chemical binding]; other site 1046624005242 Q-loop/lid; other site 1046624005243 ABC transporter signature motif; other site 1046624005244 Walker B; other site 1046624005245 D-loop; other site 1046624005246 H-loop/switch region; other site 1046624005247 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1046624005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005249 dimer interface [polypeptide binding]; other site 1046624005250 conserved gate region; other site 1046624005251 putative PBP binding loops; other site 1046624005252 ABC-ATPase subunit interface; other site 1046624005253 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1046624005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005255 dimer interface [polypeptide binding]; other site 1046624005256 conserved gate region; other site 1046624005257 putative PBP binding loops; other site 1046624005258 ABC-ATPase subunit interface; other site 1046624005259 PBP superfamily domain; Region: PBP_like_2; cl17296 1046624005260 PBP superfamily domain; Region: PBP_like_2; cl17296 1046624005261 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1046624005262 SmpB-tmRNA interface; other site 1046624005263 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1046624005264 catalytic triad [active] 1046624005265 oxyanion hole [active] 1046624005266 active site 1046624005267 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1046624005268 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1046624005269 motif 1; other site 1046624005270 active site 1046624005271 motif 2; other site 1046624005272 motif 3; other site 1046624005273 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1046624005274 DHHA1 domain; Region: DHHA1; pfam02272 1046624005275 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1046624005276 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1046624005277 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1046624005278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624005279 S-adenosylmethionine binding site [chemical binding]; other site 1046624005280 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1046624005281 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1046624005282 active site 1046624005283 Zn binding site [ion binding]; other site 1046624005284 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1046624005285 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1046624005286 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1046624005287 putative active site [active] 1046624005288 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1046624005289 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1046624005290 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1046624005291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624005292 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1046624005293 active site 1046624005294 motif I; other site 1046624005295 motif II; other site 1046624005296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1046624005297 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1046624005298 Cysteine-rich domain; Region: CCG; pfam02754 1046624005299 Cysteine-rich domain; Region: CCG; pfam02754 1046624005300 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1046624005301 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1046624005302 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1046624005303 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1046624005304 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1046624005305 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1046624005306 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1046624005307 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1046624005308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624005309 Zn2+ binding site [ion binding]; other site 1046624005310 Mg2+ binding site [ion binding]; other site 1046624005311 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1046624005312 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1046624005313 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1046624005314 AAA domain; Region: AAA_30; pfam13604 1046624005315 Family description; Region: UvrD_C_2; pfam13538 1046624005316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624005317 catalytic core [active] 1046624005318 prephenate dehydratase; Provisional; Region: PRK11898 1046624005319 Prephenate dehydratase; Region: PDT; pfam00800 1046624005320 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1046624005321 putative L-Phe binding site [chemical binding]; other site 1046624005322 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1046624005323 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1046624005324 ADP binding site [chemical binding]; other site 1046624005325 magnesium binding site [ion binding]; other site 1046624005326 putative shikimate binding site; other site 1046624005327 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1046624005328 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1046624005329 hinge; other site 1046624005330 active site 1046624005331 prephenate dehydrogenase; Validated; Region: PRK06545 1046624005332 prephenate dehydrogenase; Validated; Region: PRK08507 1046624005333 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1046624005334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1046624005335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624005336 ATP binding site [chemical binding]; other site 1046624005337 Mg2+ binding site [ion binding]; other site 1046624005338 G-X-G motif; other site 1046624005339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1046624005340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1046624005341 active site 1046624005342 phosphorylation site [posttranslational modification] 1046624005343 intermolecular recognition site; other site 1046624005344 dimerization interface [polypeptide binding]; other site 1046624005345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1046624005346 DNA binding site [nucleotide binding] 1046624005347 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1046624005348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624005349 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624005350 Walker A/P-loop; other site 1046624005351 ATP binding site [chemical binding]; other site 1046624005352 Q-loop/lid; other site 1046624005353 ABC transporter signature motif; other site 1046624005354 Walker B; other site 1046624005355 D-loop; other site 1046624005356 H-loop/switch region; other site 1046624005357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1046624005358 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1046624005359 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1046624005360 Tetramer interface [polypeptide binding]; other site 1046624005361 active site 1046624005362 FMN-binding site [chemical binding]; other site 1046624005363 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1046624005364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624005365 active site 1046624005366 motif I; other site 1046624005367 motif II; other site 1046624005368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1046624005369 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1046624005370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1046624005371 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1046624005372 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1046624005373 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1046624005374 active site 1046624005375 dimer interface [polypeptide binding]; other site 1046624005376 metal binding site [ion binding]; metal-binding site 1046624005377 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1046624005378 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1046624005379 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1046624005380 shikimate binding site; other site 1046624005381 NAD(P) binding site [chemical binding]; other site 1046624005382 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1046624005383 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1046624005384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1046624005385 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1046624005386 substrate binding pocket [chemical binding]; other site 1046624005387 membrane-bound complex binding site; other site 1046624005388 hinge residues; other site 1046624005389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1046624005390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1046624005391 substrate binding pocket [chemical binding]; other site 1046624005392 membrane-bound complex binding site; other site 1046624005393 hinge residues; other site 1046624005394 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1046624005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005396 dimer interface [polypeptide binding]; other site 1046624005397 conserved gate region; other site 1046624005398 putative PBP binding loops; other site 1046624005399 ABC-ATPase subunit interface; other site 1046624005400 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1046624005401 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1046624005402 Walker A/P-loop; other site 1046624005403 ATP binding site [chemical binding]; other site 1046624005404 Q-loop/lid; other site 1046624005405 ABC transporter signature motif; other site 1046624005406 Walker B; other site 1046624005407 D-loop; other site 1046624005408 H-loop/switch region; other site 1046624005409 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1046624005410 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1046624005411 gamma subunit interface [polypeptide binding]; other site 1046624005412 epsilon subunit interface [polypeptide binding]; other site 1046624005413 LBP interface [polypeptide binding]; other site 1046624005414 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1046624005415 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1046624005416 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1046624005417 alpha subunit interaction interface [polypeptide binding]; other site 1046624005418 Walker A motif; other site 1046624005419 ATP binding site [chemical binding]; other site 1046624005420 Walker B motif; other site 1046624005421 inhibitor binding site; inhibition site 1046624005422 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1046624005423 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1046624005424 core domain interface [polypeptide binding]; other site 1046624005425 delta subunit interface [polypeptide binding]; other site 1046624005426 epsilon subunit interface [polypeptide binding]; other site 1046624005427 F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056 1046624005428 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1046624005429 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1046624005430 beta subunit interaction interface [polypeptide binding]; other site 1046624005431 Walker A motif; other site 1046624005432 ATP binding site [chemical binding]; other site 1046624005433 Walker B motif; other site 1046624005434 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1046624005435 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1046624005436 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1046624005437 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1046624005438 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1046624005439 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1046624005440 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1046624005441 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 1046624005442 Predicted esterase [General function prediction only]; Region: COG0627 1046624005443 S-formylglutathione hydrolase; Region: PLN02442 1046624005444 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1046624005445 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1046624005446 Competence protein; Region: Competence; pfam03772 1046624005447 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1046624005448 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1046624005449 SLBB domain; Region: SLBB; pfam10531 1046624005450 comEA protein; Region: comE; TIGR01259 1046624005451 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1046624005452 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1046624005453 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1046624005454 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1046624005455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624005456 Walker A/P-loop; other site 1046624005457 ATP binding site [chemical binding]; other site 1046624005458 Q-loop/lid; other site 1046624005459 ABC transporter signature motif; other site 1046624005460 Walker B; other site 1046624005461 D-loop; other site 1046624005462 H-loop/switch region; other site 1046624005463 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1046624005464 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1046624005465 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1046624005466 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1046624005467 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1046624005468 transmembrane helices; other site 1046624005469 Putative transcription activator [Transcription]; Region: TenA; COG0819 1046624005470 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1046624005471 CHY zinc finger; Region: zf-CHY; pfam05495 1046624005472 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1046624005473 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1046624005474 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1046624005475 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1046624005476 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1046624005477 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 1046624005478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1046624005479 acyl-activating enzyme (AAE) consensus motif; other site 1046624005480 AMP binding site [chemical binding]; other site 1046624005481 active site 1046624005482 CoA binding site [chemical binding]; other site 1046624005483 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1046624005484 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1046624005485 dimer interface [polypeptide binding]; other site 1046624005486 active site 1046624005487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1046624005488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624005489 NAD(P) binding site [chemical binding]; other site 1046624005490 active site 1046624005491 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1046624005492 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1046624005493 FMN binding site [chemical binding]; other site 1046624005494 substrate binding site [chemical binding]; other site 1046624005495 putative catalytic residue [active] 1046624005496 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1046624005497 FeS assembly protein SufB; Region: sufB; TIGR01980 1046624005498 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1046624005499 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1046624005500 trimerization site [polypeptide binding]; other site 1046624005501 active site 1046624005502 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1046624005503 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1046624005504 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1046624005505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1046624005506 catalytic residue [active] 1046624005507 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1046624005508 FeS assembly protein SufD; Region: sufD; TIGR01981 1046624005509 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1046624005510 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1046624005511 Walker A/P-loop; other site 1046624005512 ATP binding site [chemical binding]; other site 1046624005513 Q-loop/lid; other site 1046624005514 ABC transporter signature motif; other site 1046624005515 Walker B; other site 1046624005516 D-loop; other site 1046624005517 H-loop/switch region; other site 1046624005518 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1046624005519 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1046624005520 Mg++ binding site [ion binding]; other site 1046624005521 putative catalytic motif [active] 1046624005522 substrate binding site [chemical binding]; other site 1046624005523 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1046624005524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1046624005525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1046624005526 Walker A/P-loop; other site 1046624005527 ATP binding site [chemical binding]; other site 1046624005528 Q-loop/lid; other site 1046624005529 ABC transporter signature motif; other site 1046624005530 Walker B; other site 1046624005531 D-loop; other site 1046624005532 H-loop/switch region; other site 1046624005533 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1046624005534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005535 dimer interface [polypeptide binding]; other site 1046624005536 conserved gate region; other site 1046624005537 putative PBP binding loops; other site 1046624005538 ABC-ATPase subunit interface; other site 1046624005539 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1046624005540 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1046624005541 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1046624005542 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1046624005543 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1046624005544 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1046624005545 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1046624005546 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1046624005547 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1046624005548 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1046624005549 G-loop; other site 1046624005550 DNA binding site [nucleotide binding] 1046624005551 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1046624005552 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1046624005553 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1046624005554 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1046624005555 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1046624005556 RPB1 interaction site [polypeptide binding]; other site 1046624005557 RPB10 interaction site [polypeptide binding]; other site 1046624005558 RPB11 interaction site [polypeptide binding]; other site 1046624005559 RPB3 interaction site [polypeptide binding]; other site 1046624005560 RPB12 interaction site [polypeptide binding]; other site 1046624005561 CodY GAF-like domain; Region: CodY; pfam06018 1046624005562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1046624005563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624005564 non-specific DNA binding site [nucleotide binding]; other site 1046624005565 salt bridge; other site 1046624005566 sequence-specific DNA binding site [nucleotide binding]; other site 1046624005567 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1046624005568 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1046624005569 active site 1046624005570 Zn binding site [ion binding]; other site 1046624005571 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1046624005572 active site 1046624005573 DNA binding site [nucleotide binding] 1046624005574 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1046624005575 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1046624005576 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1046624005577 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1046624005578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624005579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1046624005580 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1046624005581 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1046624005582 NAD binding site [chemical binding]; other site 1046624005583 substrate binding site [chemical binding]; other site 1046624005584 catalytic Zn binding site [ion binding]; other site 1046624005585 tetramer interface [polypeptide binding]; other site 1046624005586 structural Zn binding site [ion binding]; other site 1046624005587 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1046624005588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624005589 ATP binding site [chemical binding]; other site 1046624005590 putative Mg++ binding site [ion binding]; other site 1046624005591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624005592 nucleotide binding region [chemical binding]; other site 1046624005593 ATP-binding site [chemical binding]; other site 1046624005594 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1046624005595 HRDC domain; Region: HRDC; pfam00570 1046624005596 inner membrane transporter YjeM; Provisional; Region: PRK15238 1046624005597 peptidase T; Region: peptidase-T; TIGR01882 1046624005598 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1046624005599 metal binding site [ion binding]; metal-binding site 1046624005600 dimer interface [polypeptide binding]; other site 1046624005601 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1046624005602 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1046624005603 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1046624005604 DHH family; Region: DHH; pfam01368 1046624005605 DHHA2 domain; Region: DHHA2; pfam02833 1046624005606 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1046624005607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624005608 FeS/SAM binding site; other site 1046624005609 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1046624005610 Domain of unknown function DUF21; Region: DUF21; pfam01595 1046624005611 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1046624005612 Transporter associated domain; Region: CorC_HlyC; smart01091 1046624005613 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1046624005614 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1046624005615 putative nonsense mutation 1046624005616 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1046624005617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624005618 Ligand Binding Site [chemical binding]; other site 1046624005619 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1046624005620 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1046624005621 active site 1046624005622 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1046624005623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1046624005624 DNA binding residues [nucleotide binding] 1046624005625 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1046624005626 Phage capsid family; Region: Phage_capsid; pfam05065 1046624005627 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 1046624005628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624005629 non-specific DNA binding site [nucleotide binding]; other site 1046624005630 salt bridge; other site 1046624005631 sequence-specific DNA binding site [nucleotide binding]; other site 1046624005632 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1046624005633 Int/Topo IB signature motif; other site 1046624005634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1046624005635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624005636 Coenzyme A binding pocket [chemical binding]; other site 1046624005637 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1046624005638 putative uracil binding site [chemical binding]; other site 1046624005639 putative active site [active] 1046624005640 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1046624005641 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1046624005642 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1046624005643 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1046624005644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1046624005645 catalytic core [active] 1046624005646 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1046624005647 GIY-YIG motif/motif A; other site 1046624005648 putative active site [active] 1046624005649 putative metal binding site [ion binding]; other site 1046624005650 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1046624005651 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1046624005652 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1046624005653 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1046624005654 Thiamine pyrophosphokinase; Region: TPK; cd07995 1046624005655 active site 1046624005656 dimerization interface [polypeptide binding]; other site 1046624005657 thiamine binding site [chemical binding]; other site 1046624005658 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1046624005659 putative metal binding site [ion binding]; other site 1046624005660 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1046624005661 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1046624005662 putative dimer interface [polypeptide binding]; other site 1046624005663 putative anticodon binding site; other site 1046624005664 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1046624005665 homodimer interface [polypeptide binding]; other site 1046624005666 motif 1; other site 1046624005667 motif 2; other site 1046624005668 active site 1046624005669 motif 3; other site 1046624005670 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1046624005671 GIY-YIG motif/motif A; other site 1046624005672 aspartate aminotransferase; Provisional; Region: PRK05764 1046624005673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624005674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624005675 homodimer interface [polypeptide binding]; other site 1046624005676 catalytic residue [active] 1046624005677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1046624005678 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1046624005679 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1046624005680 active site 1046624005681 catalytic site [active] 1046624005682 substrate binding site [chemical binding]; other site 1046624005683 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1046624005684 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1046624005685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624005686 Ligand Binding Site [chemical binding]; other site 1046624005687 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1046624005688 Domain of unknown function DUF21; Region: DUF21; pfam01595 1046624005689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1046624005690 Transporter associated domain; Region: CorC_HlyC; smart01091 1046624005691 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1046624005692 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1046624005693 active site 1046624005694 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1046624005695 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1046624005696 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1046624005697 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1046624005698 peptide binding site [polypeptide binding]; other site 1046624005699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1046624005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005701 dimer interface [polypeptide binding]; other site 1046624005702 conserved gate region; other site 1046624005703 putative PBP binding loops; other site 1046624005704 ABC-ATPase subunit interface; other site 1046624005705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1046624005706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1046624005707 dimer interface [polypeptide binding]; other site 1046624005708 conserved gate region; other site 1046624005709 putative PBP binding loops; other site 1046624005710 ABC-ATPase subunit interface; other site 1046624005711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1046624005712 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1046624005713 Walker A/P-loop; other site 1046624005714 ATP binding site [chemical binding]; other site 1046624005715 Q-loop/lid; other site 1046624005716 ABC transporter signature motif; other site 1046624005717 Walker B; other site 1046624005718 D-loop; other site 1046624005719 H-loop/switch region; other site 1046624005720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1046624005721 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1046624005722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1046624005723 Walker A/P-loop; other site 1046624005724 ATP binding site [chemical binding]; other site 1046624005725 Q-loop/lid; other site 1046624005726 ABC transporter signature motif; other site 1046624005727 Walker B; other site 1046624005728 D-loop; other site 1046624005729 H-loop/switch region; other site 1046624005730 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1046624005731 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1046624005732 23S rRNA binding site [nucleotide binding]; other site 1046624005733 L21 binding site [polypeptide binding]; other site 1046624005734 L13 binding site [polypeptide binding]; other site 1046624005735 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1046624005736 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1046624005737 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1046624005738 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1046624005739 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1046624005740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624005741 motif II; other site 1046624005742 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1046624005743 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1046624005744 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1046624005745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1046624005746 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1046624005747 active site 1046624005748 metal binding site [ion binding]; metal-binding site 1046624005749 dimerization interface [polypeptide binding]; other site 1046624005750 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1046624005751 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1046624005752 active site 1046624005753 HIGH motif; other site 1046624005754 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1046624005755 KMSKS motif; other site 1046624005756 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1046624005757 tRNA binding surface [nucleotide binding]; other site 1046624005758 anticodon binding site; other site 1046624005759 Predicted integral membrane protein [Function unknown]; Region: COG3548 1046624005760 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1046624005761 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1046624005762 trimer interface [polypeptide binding]; other site 1046624005763 active site 1046624005764 substrate binding site [chemical binding]; other site 1046624005765 CoA binding site [chemical binding]; other site 1046624005766 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1046624005767 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1046624005768 trimer interface [polypeptide binding]; other site 1046624005769 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1046624005770 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1046624005771 RNase E interface [polypeptide binding]; other site 1046624005772 trimer interface [polypeptide binding]; other site 1046624005773 active site 1046624005774 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1046624005775 putative nucleic acid binding region [nucleotide binding]; other site 1046624005776 G-X-X-G motif; other site 1046624005777 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1046624005778 RNA binding site [nucleotide binding]; other site 1046624005779 domain interface; other site 1046624005780 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1046624005781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1046624005782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624005783 active site 1046624005784 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624005785 Ligand Binding Site [chemical binding]; other site 1046624005786 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1046624005787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1046624005788 catalytic residue [active] 1046624005789 Putative amino acid metabolism; Region: DUF1831; pfam08866 1046624005790 elongation factor Tu; Reviewed; Region: PRK00049 1046624005791 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1046624005792 G1 box; other site 1046624005793 GEF interaction site [polypeptide binding]; other site 1046624005794 GTP/Mg2+ binding site [chemical binding]; other site 1046624005795 Switch I region; other site 1046624005796 G2 box; other site 1046624005797 G3 box; other site 1046624005798 Switch II region; other site 1046624005799 G4 box; other site 1046624005800 G5 box; other site 1046624005801 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1046624005802 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1046624005803 Antibiotic Binding Site [chemical binding]; other site 1046624005804 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1046624005805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624005806 active site 1046624005807 HIGH motif; other site 1046624005808 nucleotide binding site [chemical binding]; other site 1046624005809 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1046624005810 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1046624005811 active site 1046624005812 KMSKS motif; other site 1046624005813 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1046624005814 tRNA binding surface [nucleotide binding]; other site 1046624005815 anticodon binding site; other site 1046624005816 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1046624005817 DivIVA protein; Region: DivIVA; pfam05103 1046624005818 DivIVA domain; Region: DivI1A_domain; TIGR03544 1046624005819 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1046624005820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1046624005821 YGGT family; Region: YGGT; pfam02325 1046624005822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1046624005823 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1046624005824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1046624005825 catalytic residue [active] 1046624005826 cell division protein FtsZ; Validated; Region: PRK09330 1046624005827 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1046624005828 nucleotide binding site [chemical binding]; other site 1046624005829 SulA interaction site; other site 1046624005830 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1046624005831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624005832 nucleotide binding site [chemical binding]; other site 1046624005833 Cell division protein FtsA; Region: FtsA; pfam14450 1046624005834 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1046624005835 EDD domain protein, DegV family; Region: DegV; TIGR00762 1046624005836 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1046624005837 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1046624005838 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1046624005839 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1046624005840 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1046624005841 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624005842 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624005843 active site 1046624005844 catalytic tetrad [active] 1046624005845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624005846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624005847 putative substrate translocation pore; other site 1046624005848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1046624005849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1046624005850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1046624005851 dimerization interface [polypeptide binding]; other site 1046624005852 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1046624005853 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1046624005854 DNA binding residues [nucleotide binding] 1046624005855 putative dimer interface [polypeptide binding]; other site 1046624005856 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1046624005857 trimer interface [polypeptide binding]; other site 1046624005858 active site 1046624005859 G bulge; other site 1046624005860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624005861 Zn2+ binding site [ion binding]; other site 1046624005862 Mg2+ binding site [ion binding]; other site 1046624005863 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1046624005864 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1046624005865 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1046624005866 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1046624005867 dimer interface [polypeptide binding]; other site 1046624005868 ADP-ribose binding site [chemical binding]; other site 1046624005869 active site 1046624005870 nudix motif; other site 1046624005871 metal binding site [ion binding]; metal-binding site 1046624005872 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1046624005873 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1046624005874 Substrate binding site; other site 1046624005875 Mg++ binding site; other site 1046624005876 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1046624005877 active site 1046624005878 substrate binding site [chemical binding]; other site 1046624005879 CoA binding site [chemical binding]; other site 1046624005880 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1046624005881 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1046624005882 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1046624005883 16S/18S rRNA binding site [nucleotide binding]; other site 1046624005884 S13e-L30e interaction site [polypeptide binding]; other site 1046624005885 25S rRNA binding site [nucleotide binding]; other site 1046624005886 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1046624005887 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1046624005888 active site 1046624005889 ATP binding site [chemical binding]; other site 1046624005890 substrate binding site [chemical binding]; other site 1046624005891 activation loop (A-loop); other site 1046624005892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1046624005893 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1046624005894 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1046624005895 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1046624005896 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1046624005897 active site 1046624005898 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1046624005899 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1046624005900 putative RNA binding site [nucleotide binding]; other site 1046624005901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624005902 S-adenosylmethionine binding site [chemical binding]; other site 1046624005903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1046624005904 Predicted membrane protein [Function unknown]; Region: COG2261 1046624005905 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1046624005906 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1046624005907 putative active site [active] 1046624005908 substrate binding site [chemical binding]; other site 1046624005909 putative cosubstrate binding site; other site 1046624005910 catalytic site [active] 1046624005911 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1046624005912 substrate binding site [chemical binding]; other site 1046624005913 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1046624005914 dimer interface [polypeptide binding]; other site 1046624005915 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1046624005916 nudix motif; other site 1046624005917 SnoaL-like domain; Region: SnoaL_2; pfam12680 1046624005918 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1046624005919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624005920 ATP binding site [chemical binding]; other site 1046624005921 putative Mg++ binding site [ion binding]; other site 1046624005922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624005923 nucleotide binding region [chemical binding]; other site 1046624005924 ATP-binding site [chemical binding]; other site 1046624005925 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1046624005926 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1046624005927 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1046624005928 catalytic site [active] 1046624005929 G-X2-G-X-G-K; other site 1046624005930 phosphodiesterase; Provisional; Region: PRK12704 1046624005931 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1046624005932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624005933 Zn2+ binding site [ion binding]; other site 1046624005934 Mg2+ binding site [ion binding]; other site 1046624005935 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1046624005936 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1046624005937 active site 1046624005938 trimer interface [polypeptide binding]; other site 1046624005939 allosteric site; other site 1046624005940 active site lid [active] 1046624005941 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1046624005942 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1046624005943 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1046624005944 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1046624005945 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1046624005946 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1046624005947 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1046624005948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624005949 S-adenosylmethionine binding site [chemical binding]; other site 1046624005950 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1046624005951 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1046624005952 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1046624005953 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1046624005954 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1046624005955 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1046624005956 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1046624005957 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1046624005958 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1046624005959 CHAP domain; Region: CHAP; pfam05257 1046624005960 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1046624005961 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1046624005962 intersubunit interface [polypeptide binding]; other site 1046624005963 active site 1046624005964 zinc binding site [ion binding]; other site 1046624005965 Na+ binding site [ion binding]; other site 1046624005966 Predicted membrane protein [Function unknown]; Region: COG2860 1046624005967 UPF0126 domain; Region: UPF0126; pfam03458 1046624005968 UPF0126 domain; Region: UPF0126; pfam03458 1046624005969 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1046624005970 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1046624005971 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1046624005972 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1046624005973 active site 1046624005974 dimer interface [polypeptide binding]; other site 1046624005975 motif 1; other site 1046624005976 motif 2; other site 1046624005977 motif 3; other site 1046624005978 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1046624005979 anticodon binding site; other site 1046624005980 ATP cone domain; Region: ATP-cone; pfam03477 1046624005981 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1046624005982 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1046624005983 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1046624005984 dimer interface [polypeptide binding]; other site 1046624005985 FMN binding site [chemical binding]; other site 1046624005986 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624005987 active site 1046624005988 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1046624005989 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1046624005990 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1046624005991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624005992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624005993 homodimer interface [polypeptide binding]; other site 1046624005994 catalytic residue [active] 1046624005995 cystathionine gamma-synthase; Reviewed; Region: PRK07269 1046624005996 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1046624005997 homodimer interface [polypeptide binding]; other site 1046624005998 substrate-cofactor binding pocket; other site 1046624005999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624006000 catalytic residue [active] 1046624006001 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 1046624006002 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1046624006003 proposed active site lysine [active] 1046624006004 conserved cys residue [active] 1046624006005 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1046624006006 nudix motif; other site 1046624006007 Predicted permeases [General function prediction only]; Region: COG0679 1046624006008 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1046624006009 active site 1046624006010 catalytic residues [active] 1046624006011 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1046624006012 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1046624006013 generic binding surface II; other site 1046624006014 generic binding surface I; other site 1046624006015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1046624006016 Zn2+ binding site [ion binding]; other site 1046624006017 Mg2+ binding site [ion binding]; other site 1046624006018 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1046624006019 RmuC family; Region: RmuC; pfam02646 1046624006020 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1046624006021 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1046624006022 substrate binding site [chemical binding]; other site 1046624006023 hexamer interface [polypeptide binding]; other site 1046624006024 metal binding site [ion binding]; metal-binding site 1046624006025 GTPase RsgA; Reviewed; Region: PRK00098 1046624006026 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1046624006027 RNA binding site [nucleotide binding]; other site 1046624006028 homodimer interface [polypeptide binding]; other site 1046624006029 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1046624006030 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1046624006031 GTP/Mg2+ binding site [chemical binding]; other site 1046624006032 G4 box; other site 1046624006033 G1 box; other site 1046624006034 Switch I region; other site 1046624006035 G2 box; other site 1046624006036 G3 box; other site 1046624006037 Switch II region; other site 1046624006038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1046624006039 3D domain; Region: 3D; cl01439 1046624006040 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1046624006041 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1046624006042 putative tRNA-binding site [nucleotide binding]; other site 1046624006043 B3/4 domain; Region: B3_4; pfam03483 1046624006044 tRNA synthetase B5 domain; Region: B5; smart00874 1046624006045 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1046624006046 dimer interface [polypeptide binding]; other site 1046624006047 motif 1; other site 1046624006048 motif 3; other site 1046624006049 motif 2; other site 1046624006050 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1046624006051 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1046624006052 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1046624006053 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1046624006054 dimer interface [polypeptide binding]; other site 1046624006055 motif 1; other site 1046624006056 active site 1046624006057 motif 2; other site 1046624006058 motif 3; other site 1046624006059 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 1046624006060 Predicted transcriptional regulators [Transcription]; Region: COG1695 1046624006061 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1046624006062 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1046624006063 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1046624006064 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1046624006065 putative active site [active] 1046624006066 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1046624006067 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1046624006068 Interdomain contacts; other site 1046624006069 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1046624006070 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1046624006071 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1046624006072 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1046624006073 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1046624006074 GDP-binding site [chemical binding]; other site 1046624006075 ACT binding site; other site 1046624006076 IMP binding site; other site 1046624006077 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1046624006078 Cadmium resistance transporter; Region: Cad; pfam03596 1046624006079 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1046624006080 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1046624006081 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1046624006082 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1046624006083 dimerization interface [polypeptide binding]; other site 1046624006084 domain crossover interface; other site 1046624006085 redox-dependent activation switch; other site 1046624006086 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1046624006087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1046624006088 NADP+ binding site [chemical binding]; other site 1046624006089 folate binding site [chemical binding]; other site 1046624006090 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1046624006091 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1046624006092 FMN binding site [chemical binding]; other site 1046624006093 active site 1046624006094 catalytic residues [active] 1046624006095 substrate binding site [chemical binding]; other site 1046624006096 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1046624006097 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006098 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006099 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1046624006100 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1046624006101 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006102 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006103 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1046624006104 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1046624006105 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006106 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1046624006107 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1046624006108 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1046624006109 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1046624006110 dimer interface [polypeptide binding]; other site 1046624006111 anticodon binding site; other site 1046624006112 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1046624006113 homodimer interface [polypeptide binding]; other site 1046624006114 motif 1; other site 1046624006115 active site 1046624006116 motif 2; other site 1046624006117 GAD domain; Region: GAD; pfam02938 1046624006118 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1046624006119 active site 1046624006120 motif 3; other site 1046624006121 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1046624006122 nucleotide binding site/active site [active] 1046624006123 HIT family signature motif; other site 1046624006124 catalytic residue [active] 1046624006125 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1046624006126 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1046624006127 dimer interface [polypeptide binding]; other site 1046624006128 motif 1; other site 1046624006129 active site 1046624006130 motif 2; other site 1046624006131 motif 3; other site 1046624006132 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1046624006133 anticodon binding site; other site 1046624006134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1046624006135 non-specific DNA binding site [nucleotide binding]; other site 1046624006136 salt bridge; other site 1046624006137 sequence-specific DNA binding site [nucleotide binding]; other site 1046624006138 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624006139 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1046624006140 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1046624006141 Helix-turn-helix domain; Region: HTH_25; pfam13413 1046624006142 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1046624006143 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1046624006144 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1046624006145 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1046624006146 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1046624006147 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 1046624006148 recF protein; Region: recf; TIGR00611 1046624006149 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1046624006150 Walker A/P-loop; other site 1046624006151 ATP binding site [chemical binding]; other site 1046624006152 Q-loop/lid; other site 1046624006153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624006154 ABC transporter signature motif; other site 1046624006155 Walker B; other site 1046624006156 D-loop; other site 1046624006157 H-loop/switch region; other site 1046624006158 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1046624006159 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1046624006160 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1046624006161 DNA binding residues [nucleotide binding] 1046624006162 putative dimer interface [polypeptide binding]; other site 1046624006163 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1046624006164 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1046624006165 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1046624006166 NAD binding site [chemical binding]; other site 1046624006167 homodimer interface [polypeptide binding]; other site 1046624006168 active site 1046624006169 substrate binding site [chemical binding]; other site 1046624006170 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1046624006171 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1046624006172 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1046624006173 galactokinase; Provisional; Region: PRK05322 1046624006174 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1046624006175 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1046624006176 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1046624006177 active site 1046624006178 catalytic residues [active] 1046624006179 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1046624006180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624006181 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624006182 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624006183 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624006184 putative active site [active] 1046624006185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1046624006186 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1046624006187 active site 1046624006188 catalytic tetrad [active] 1046624006189 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1046624006190 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1046624006191 active site 1046624006192 (T/H)XGH motif; other site 1046624006193 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1046624006194 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1046624006195 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1046624006196 NAD binding site [chemical binding]; other site 1046624006197 ligand binding site [chemical binding]; other site 1046624006198 catalytic site [active] 1046624006199 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1046624006200 Peptidase family U32; Region: Peptidase_U32; pfam01136 1046624006201 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1046624006202 Peptidase family U32; Region: Peptidase_U32; pfam01136 1046624006203 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 1046624006204 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1046624006205 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1046624006206 S-adenosylmethionine binding site [chemical binding]; other site 1046624006207 CutC family; Region: CutC; pfam03932 1046624006208 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1046624006209 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1046624006210 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1046624006211 Walker A/P-loop; other site 1046624006212 ATP binding site [chemical binding]; other site 1046624006213 Q-loop/lid; other site 1046624006214 ABC transporter signature motif; other site 1046624006215 Walker B; other site 1046624006216 D-loop; other site 1046624006217 H-loop/switch region; other site 1046624006218 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1046624006219 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1046624006220 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1046624006221 putative active site [active] 1046624006222 catalytic site [active] 1046624006223 putative metal binding site [ion binding]; other site 1046624006224 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1046624006225 HIT family signature motif; other site 1046624006226 catalytic residue [active] 1046624006227 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1046624006228 mRNA/rRNA interface [nucleotide binding]; other site 1046624006229 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1046624006230 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1046624006231 23S rRNA interface [nucleotide binding]; other site 1046624006232 L7/L12 interface [polypeptide binding]; other site 1046624006233 putative thiostrepton binding site; other site 1046624006234 L25 interface [polypeptide binding]; other site 1046624006235 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1046624006236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624006237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624006238 motif II; other site 1046624006239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1046624006240 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1046624006241 ligand binding site [chemical binding]; other site 1046624006242 flexible hinge region; other site 1046624006243 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1046624006244 putative switch regulator; other site 1046624006245 non-specific DNA interactions [nucleotide binding]; other site 1046624006246 DNA binding site [nucleotide binding] 1046624006247 sequence specific DNA binding site [nucleotide binding]; other site 1046624006248 putative cAMP binding site [chemical binding]; other site 1046624006249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1046624006250 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1046624006251 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1046624006252 S1 domain; Region: S1_2; pfam13509 1046624006253 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1046624006254 RNA binding site [nucleotide binding]; other site 1046624006255 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1046624006256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624006257 Coenzyme A binding pocket [chemical binding]; other site 1046624006258 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1046624006259 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1046624006260 hinge region; other site 1046624006261 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1046624006262 putative nucleotide binding site [chemical binding]; other site 1046624006263 uridine monophosphate binding site [chemical binding]; other site 1046624006264 homohexameric interface [polypeptide binding]; other site 1046624006265 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1046624006266 propionate/acetate kinase; Provisional; Region: PRK12379 1046624006267 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1046624006268 propionate/acetate kinase; Provisional; Region: PRK12379 1046624006269 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1046624006270 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1046624006271 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1046624006272 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1046624006273 G1 box; other site 1046624006274 putative GEF interaction site [polypeptide binding]; other site 1046624006275 GTP/Mg2+ binding site [chemical binding]; other site 1046624006276 Switch I region; other site 1046624006277 G2 box; other site 1046624006278 G3 box; other site 1046624006279 Switch II region; other site 1046624006280 G4 box; other site 1046624006281 G5 box; other site 1046624006282 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1046624006283 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1046624006284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624006285 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1046624006286 Walker A/P-loop; other site 1046624006287 ATP binding site [chemical binding]; other site 1046624006288 Q-loop/lid; other site 1046624006289 ABC transporter signature motif; other site 1046624006290 Walker B; other site 1046624006291 D-loop; other site 1046624006292 H-loop/switch region; other site 1046624006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1046624006294 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1046624006295 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 1046624006296 LytTr DNA-binding domain; Region: LytTR; pfam04397 1046624006297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1046624006298 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1046624006299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1046624006300 nucleotide binding site [chemical binding]; other site 1046624006301 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1046624006302 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1046624006303 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1046624006304 dimerization interface [polypeptide binding]; other site 1046624006305 DPS ferroxidase diiron center [ion binding]; other site 1046624006306 ion pore; other site 1046624006307 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1046624006308 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1046624006309 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1046624006310 active site 1046624006311 DNA polymerase IV; Validated; Region: PRK02406 1046624006312 DNA binding site [nucleotide binding] 1046624006313 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1046624006314 putative deacylase active site [active] 1046624006315 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1046624006316 transaminase; Validated; Region: PRK07324 1046624006317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1046624006318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624006319 homodimer interface [polypeptide binding]; other site 1046624006320 catalytic residue [active] 1046624006321 carbamate kinase; Reviewed; Region: PRK12686 1046624006322 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1046624006323 putative substrate binding site [chemical binding]; other site 1046624006324 nucleotide binding site [chemical binding]; other site 1046624006325 nucleotide binding site [chemical binding]; other site 1046624006326 homodimer interface [polypeptide binding]; other site 1046624006327 carbamate kinase; Reviewed; Region: PRK12686 1046624006328 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1046624006329 putative substrate binding site [chemical binding]; other site 1046624006330 nucleotide binding site [chemical binding]; other site 1046624006331 nucleotide binding site [chemical binding]; other site 1046624006332 homodimer interface [polypeptide binding]; other site 1046624006333 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1046624006334 ornithine carbamoyltransferase; Validated; Region: PRK02102 1046624006335 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1046624006336 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1046624006337 arginine deiminase; Provisional; Region: PRK01388 1046624006338 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1046624006339 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1046624006340 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1046624006341 active site 1046624006342 HIGH motif; other site 1046624006343 KMSK motif region; other site 1046624006344 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1046624006345 tRNA binding surface [nucleotide binding]; other site 1046624006346 anticodon binding site; other site 1046624006347 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1046624006348 arginine repressor; Region: argR_whole; TIGR01529 1046624006349 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1046624006350 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1046624006351 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1046624006352 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1046624006353 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1046624006354 SWIM zinc finger; Region: SWIM; pfam04434 1046624006355 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1046624006356 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1046624006357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624006358 ATP binding site [chemical binding]; other site 1046624006359 putative Mg++ binding site [ion binding]; other site 1046624006360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624006361 nucleotide binding region [chemical binding]; other site 1046624006362 ATP-binding site [chemical binding]; other site 1046624006363 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1046624006364 metal ion-dependent adhesion site (MIDAS); other site 1046624006365 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1046624006366 domain interaction interfaces [polypeptide binding]; other site 1046624006367 Cna protein B-type domain; Region: Cna_B; pfam05738 1046624006368 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1046624006369 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1046624006370 PYR/PP interface [polypeptide binding]; other site 1046624006371 dimer interface [polypeptide binding]; other site 1046624006372 tetramer interface [polypeptide binding]; other site 1046624006373 TPP binding site [chemical binding]; other site 1046624006374 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1046624006375 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1046624006376 TPP-binding site [chemical binding]; other site 1046624006377 Beta-lactamase; Region: Beta-lactamase; pfam00144 1046624006378 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1046624006379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1046624006380 CAAX protease self-immunity; Region: Abi; pfam02517 1046624006381 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1046624006382 amphipathic channel; other site 1046624006383 Asn-Pro-Ala signature motifs; other site 1046624006384 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1046624006385 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1046624006386 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1046624006387 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1046624006388 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1046624006389 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1046624006390 catalytic triad [active] 1046624006391 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1046624006392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1046624006393 substrate binding pocket [chemical binding]; other site 1046624006394 membrane-bound complex binding site; other site 1046624006395 hinge residues; other site 1046624006396 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1046624006397 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1046624006398 active site 1046624006399 HIGH motif; other site 1046624006400 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1046624006401 active site 1046624006402 KMSKS motif; other site 1046624006403 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1046624006404 Isochorismatase family; Region: Isochorismatase; pfam00857 1046624006405 catalytic triad [active] 1046624006406 conserved cis-peptide bond; other site 1046624006407 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1046624006408 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1046624006409 active site 1046624006410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1046624006411 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1046624006412 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1046624006413 Predicted transcriptional regulators [Transcription]; Region: COG1695 1046624006414 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1046624006415 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1046624006416 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1046624006417 putative active site [active] 1046624006418 Predicted membrane protein [Function unknown]; Region: COG3619 1046624006419 DNA repair protein RadA; Provisional; Region: PRK11823 1046624006420 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1046624006421 Walker A motif/ATP binding site; other site 1046624006422 ATP binding site [chemical binding]; other site 1046624006423 Walker B motif; other site 1046624006424 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1046624006425 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1046624006426 metal-binding site [ion binding] 1046624006427 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1046624006428 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1046624006429 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1046624006430 alphaNTD homodimer interface [polypeptide binding]; other site 1046624006431 alphaNTD - beta interaction site [polypeptide binding]; other site 1046624006432 alphaNTD - beta' interaction site [polypeptide binding]; other site 1046624006433 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1046624006434 30S ribosomal protein S11; Validated; Region: PRK05309 1046624006435 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1046624006436 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1046624006437 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1046624006438 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1046624006439 rRNA binding site [nucleotide binding]; other site 1046624006440 predicted 30S ribosome binding site; other site 1046624006441 adenylate kinase; Reviewed; Region: adk; PRK00279 1046624006442 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1046624006443 AMP-binding site [chemical binding]; other site 1046624006444 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1046624006445 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1046624006446 SecY translocase; Region: SecY; pfam00344 1046624006447 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1046624006448 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1046624006449 23S rRNA binding site [nucleotide binding]; other site 1046624006450 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1046624006451 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1046624006452 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1046624006453 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1046624006454 5S rRNA interface [nucleotide binding]; other site 1046624006455 L27 interface [polypeptide binding]; other site 1046624006456 23S rRNA interface [nucleotide binding]; other site 1046624006457 L5 interface [polypeptide binding]; other site 1046624006458 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1046624006459 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1046624006460 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1046624006461 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1046624006462 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1046624006463 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1046624006464 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1046624006465 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1046624006466 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1046624006467 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1046624006468 RNA binding site [nucleotide binding]; other site 1046624006469 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1046624006470 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1046624006471 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1046624006472 23S rRNA interface [nucleotide binding]; other site 1046624006473 putative translocon interaction site; other site 1046624006474 signal recognition particle (SRP54) interaction site; other site 1046624006475 L23 interface [polypeptide binding]; other site 1046624006476 trigger factor interaction site; other site 1046624006477 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1046624006478 23S rRNA interface [nucleotide binding]; other site 1046624006479 5S rRNA interface [nucleotide binding]; other site 1046624006480 putative antibiotic binding site [chemical binding]; other site 1046624006481 L25 interface [polypeptide binding]; other site 1046624006482 L27 interface [polypeptide binding]; other site 1046624006483 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1046624006484 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1046624006485 G-X-X-G motif; other site 1046624006486 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1046624006487 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1046624006488 putative translocon binding site; other site 1046624006489 protein-rRNA interface [nucleotide binding]; other site 1046624006490 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1046624006491 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1046624006492 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1046624006493 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1046624006494 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1046624006495 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1046624006496 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1046624006497 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1046624006498 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1046624006499 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1046624006500 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1046624006501 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1046624006502 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1046624006503 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1046624006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1046624006505 catalytic residue [active] 1046624006506 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1046624006507 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1046624006508 putative homodimer interface [polypeptide binding]; other site 1046624006509 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1046624006510 heterodimer interface [polypeptide binding]; other site 1046624006511 homodimer interface [polypeptide binding]; other site 1046624006512 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1046624006513 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1046624006514 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1046624006515 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1046624006516 catalytic triad [active] 1046624006517 catalytic triad [active] 1046624006518 oxyanion hole [active] 1046624006519 Transglycosylase; Region: Transgly; pfam00912 1046624006520 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1046624006521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1046624006522 Predicted membrane protein [Function unknown]; Region: COG2323 1046624006523 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1046624006524 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1046624006525 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1046624006526 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1046624006527 active site 1046624006528 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1046624006529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1046624006530 ABC-ATPase subunit interface; other site 1046624006531 dimer interface [polypeptide binding]; other site 1046624006532 putative PBP binding regions; other site 1046624006533 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1046624006534 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1046624006535 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1046624006536 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1046624006537 metal binding site [ion binding]; metal-binding site 1046624006538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1046624006539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624006540 putative DNA binding site [nucleotide binding]; other site 1046624006541 putative Zn2+ binding site [ion binding]; other site 1046624006542 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1046624006543 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1046624006544 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1046624006545 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1046624006546 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1046624006547 Type II/IV secretion system protein; Region: T2SE; pfam00437 1046624006548 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1046624006549 Walker A motif; other site 1046624006550 ATP binding site [chemical binding]; other site 1046624006551 Walker B motif; other site 1046624006552 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1046624006553 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 1046624006554 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1046624006555 generic binding surface II; other site 1046624006556 generic binding surface I; other site 1046624006557 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1046624006558 generic binding surface II; other site 1046624006559 generic binding surface I; other site 1046624006560 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1046624006561 active site 1046624006562 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1046624006563 active site 1046624006564 catalytic site [active] 1046624006565 substrate binding site [chemical binding]; other site 1046624006566 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1046624006567 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1046624006568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1046624006569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1046624006570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1046624006571 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1046624006572 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1046624006573 dimer interface [polypeptide binding]; other site 1046624006574 motif 1; other site 1046624006575 active site 1046624006576 motif 2; other site 1046624006577 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1046624006578 putative deacylase active site [active] 1046624006579 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1046624006580 active site 1046624006581 motif 3; other site 1046624006582 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1046624006583 anticodon binding site; other site 1046624006584 RIP metalloprotease RseP; Region: TIGR00054 1046624006585 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1046624006586 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1046624006587 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1046624006588 protein binding site [polypeptide binding]; other site 1046624006589 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1046624006590 putative substrate binding region [chemical binding]; other site 1046624006591 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1046624006592 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1046624006593 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1046624006594 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1046624006595 catalytic residue [active] 1046624006596 putative FPP diphosphate binding site; other site 1046624006597 putative FPP binding hydrophobic cleft; other site 1046624006598 dimer interface [polypeptide binding]; other site 1046624006599 putative IPP diphosphate binding site; other site 1046624006600 Preprotein translocase subunit; Region: YajC; cl00806 1046624006601 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1046624006602 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1046624006603 active site 1046624006604 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1046624006605 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1046624006606 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1046624006607 protein binding site [polypeptide binding]; other site 1046624006608 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1046624006609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1046624006610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1046624006611 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1046624006612 putative ADP-binding pocket [chemical binding]; other site 1046624006613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1046624006614 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1046624006615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624006616 S-adenosylmethionine binding site [chemical binding]; other site 1046624006617 DNA polymerase I; Provisional; Region: PRK05755 1046624006618 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1046624006619 active site 1046624006620 metal binding site 1 [ion binding]; metal-binding site 1046624006621 putative 5' ssDNA interaction site; other site 1046624006622 metal binding site 3; metal-binding site 1046624006623 metal binding site 2 [ion binding]; metal-binding site 1046624006624 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1046624006625 putative DNA binding site [nucleotide binding]; other site 1046624006626 putative metal binding site [ion binding]; other site 1046624006627 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1046624006628 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1046624006629 active site 1046624006630 DNA binding site [nucleotide binding] 1046624006631 catalytic site [active] 1046624006632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1046624006633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1046624006634 DNA binding site [nucleotide binding] 1046624006635 domain linker motif; other site 1046624006636 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1046624006637 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1046624006638 elongation factor Ts; Provisional; Region: tsf; PRK09377 1046624006639 UBA/TS-N domain; Region: UBA; pfam00627 1046624006640 Elongation factor TS; Region: EF_TS; pfam00889 1046624006641 Elongation factor TS; Region: EF_TS; pfam00889 1046624006642 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1046624006643 rRNA interaction site [nucleotide binding]; other site 1046624006644 S8 interaction site; other site 1046624006645 putative laminin-1 binding site; other site 1046624006646 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1046624006647 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1046624006648 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1046624006649 putative catalytic cysteine [active] 1046624006650 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1046624006651 putative active site [active] 1046624006652 metal binding site [ion binding]; metal-binding site 1046624006653 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1046624006654 dimer interface [polypeptide binding]; other site 1046624006655 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1046624006656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624006657 FeS/SAM binding site; other site 1046624006658 Helix-turn-helix domain; Region: HTH_19; pfam12844 1046624006659 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624006660 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1046624006661 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1046624006662 protein binding site [polypeptide binding]; other site 1046624006663 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1046624006664 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 1046624006665 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1046624006666 active site 1046624006667 (T/H)XGH motif; other site 1046624006668 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1046624006669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624006670 S-adenosylmethionine binding site [chemical binding]; other site 1046624006671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624006672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624006673 putative substrate translocation pore; other site 1046624006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624006675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624006676 putative substrate translocation pore; other site 1046624006677 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1046624006678 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1046624006679 active site 1046624006680 dimer interface [polypeptide binding]; other site 1046624006681 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1046624006682 dimer interface [polypeptide binding]; other site 1046624006683 active site 1046624006684 Flagellin N-methylase; Region: FliB; pfam03692 1046624006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624006686 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1046624006687 NAD(P) binding site [chemical binding]; other site 1046624006688 active site 1046624006689 Predicted transcriptional regulators [Transcription]; Region: COG1733 1046624006690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1046624006691 dimerization interface [polypeptide binding]; other site 1046624006692 putative DNA binding site [nucleotide binding]; other site 1046624006693 putative Zn2+ binding site [ion binding]; other site 1046624006694 Casein kinase II regulatory subunit; Region: CK_II_beta; cl02099 1046624006695 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1046624006696 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1046624006697 active site 1046624006698 HIGH motif; other site 1046624006699 nucleotide binding site [chemical binding]; other site 1046624006700 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1046624006701 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1046624006702 active site 1046624006703 KMSKS motif; other site 1046624006704 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1046624006705 tRNA binding surface [nucleotide binding]; other site 1046624006706 anticodon binding site; other site 1046624006707 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1046624006708 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1046624006709 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1046624006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1046624006711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1046624006712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1046624006713 Coenzyme A binding pocket [chemical binding]; other site 1046624006714 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1046624006715 B3/4 domain; Region: B3_4; pfam03483 1046624006716 TRAM domain; Region: TRAM; pfam01938 1046624006717 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1046624006718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1046624006719 S-adenosylmethionine binding site [chemical binding]; other site 1046624006720 legume lectins; Region: lectin_L-type; cd01951 1046624006721 homotetramer interaction site [polypeptide binding]; other site 1046624006722 carbohydrate binding site [chemical binding]; other site 1046624006723 metal binding site [ion binding]; metal-binding site 1046624006724 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1046624006725 MucBP domain; Region: MucBP; pfam06458 1046624006726 MucBP domain; Region: MucBP; pfam06458 1046624006727 MucBP domain; Region: MucBP; pfam06458 1046624006728 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1046624006729 recombination regulator RecX; Provisional; Region: recX; PRK14135 1046624006730 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1046624006731 GntP family permease; Region: GntP_permease; pfam02447 1046624006732 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1046624006733 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1046624006734 N- and C-terminal domain interface [polypeptide binding]; other site 1046624006735 active site 1046624006736 catalytic site [active] 1046624006737 metal binding site [ion binding]; metal-binding site 1046624006738 carbohydrate binding site [chemical binding]; other site 1046624006739 ATP binding site [chemical binding]; other site 1046624006740 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1046624006741 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1046624006742 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1046624006743 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1046624006744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1046624006745 putative active site [active] 1046624006746 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1046624006747 phosphodiesterase YaeI; Provisional; Region: PRK11340 1046624006748 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1046624006749 putative active site [active] 1046624006750 putative metal binding site [ion binding]; other site 1046624006751 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1046624006752 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1046624006753 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1046624006754 dimer interface [polypeptide binding]; other site 1046624006755 ssDNA binding site [nucleotide binding]; other site 1046624006756 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624006757 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1046624006758 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1046624006759 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1046624006760 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1046624006761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624006762 Walker A motif; other site 1046624006763 ATP binding site [chemical binding]; other site 1046624006764 Walker B motif; other site 1046624006765 arginine finger; other site 1046624006766 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1046624006767 Phosphotransferase enzyme family; Region: APH; pfam01636 1046624006768 substrate binding site [chemical binding]; other site 1046624006769 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1046624006770 hypothetical protein; Provisional; Region: PRK07248 1046624006771 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1046624006772 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1046624006773 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1046624006774 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1046624006775 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1046624006776 DNA binding residues [nucleotide binding] 1046624006777 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1046624006778 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1046624006779 active site 1046624006780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1046624006781 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1046624006782 Walker A/P-loop; other site 1046624006783 ATP binding site [chemical binding]; other site 1046624006784 Q-loop/lid; other site 1046624006785 ABC transporter signature motif; other site 1046624006786 Walker B; other site 1046624006787 D-loop; other site 1046624006788 H-loop/switch region; other site 1046624006789 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1046624006790 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1046624006791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1046624006792 Walker A motif; other site 1046624006793 ATP binding site [chemical binding]; other site 1046624006794 Walker B motif; other site 1046624006795 arginine finger; other site 1046624006796 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1046624006797 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1046624006798 RuvA N terminal domain; Region: RuvA_N; pfam01330 1046624006799 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1046624006800 helix-hairpin-helix signature motif; other site 1046624006801 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1046624006802 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1046624006803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1046624006804 ATP binding site [chemical binding]; other site 1046624006805 Mg2+ binding site [ion binding]; other site 1046624006806 G-X-G motif; other site 1046624006807 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1046624006808 ATP binding site [chemical binding]; other site 1046624006809 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1046624006810 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1046624006811 MutS domain I; Region: MutS_I; pfam01624 1046624006812 MutS domain II; Region: MutS_II; pfam05188 1046624006813 MutS domain III; Region: MutS_III; pfam05192 1046624006814 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1046624006815 Walker A/P-loop; other site 1046624006816 ATP binding site [chemical binding]; other site 1046624006817 Q-loop/lid; other site 1046624006818 ABC transporter signature motif; other site 1046624006819 Walker B; other site 1046624006820 D-loop; other site 1046624006821 H-loop/switch region; other site 1046624006822 Predicted membrane protein [Function unknown]; Region: COG4550 1046624006823 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1046624006824 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1046624006825 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1046624006826 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1046624006827 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1046624006828 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1046624006829 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1046624006830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624006831 active site 1046624006832 motif I; other site 1046624006833 motif II; other site 1046624006834 chaperone protein DnaJ; Provisional; Region: PRK14276 1046624006835 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1046624006836 HSP70 interaction site [polypeptide binding]; other site 1046624006837 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1046624006838 substrate binding site [polypeptide binding]; other site 1046624006839 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1046624006840 Zn binding sites [ion binding]; other site 1046624006841 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1046624006842 substrate binding site [polypeptide binding]; other site 1046624006843 dimer interface [polypeptide binding]; other site 1046624006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1046624006845 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1046624006846 aspartate racemase; Region: asp_race; TIGR00035 1046624006847 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1046624006848 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1046624006849 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1046624006850 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1046624006851 active site 1046624006852 dimer interface [polypeptide binding]; other site 1046624006853 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1046624006854 Ligand Binding Site [chemical binding]; other site 1046624006855 Molecular Tunnel; other site 1046624006856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1046624006857 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1046624006858 Surface antigen [General function prediction only]; Region: COG3942 1046624006859 CHAP domain; Region: CHAP; pfam05257 1046624006860 rod shape-determining protein MreD; Region: MreD; pfam04093 1046624006861 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1046624006862 rod shape-determining protein MreC; Region: MreC; pfam04085 1046624006863 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1046624006864 nudix motif; other site 1046624006865 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1046624006866 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1046624006867 active site 1046624006868 dimer interface [polypeptide binding]; other site 1046624006869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1046624006870 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1046624006871 ligand binding site [chemical binding]; other site 1046624006872 flexible hinge region; other site 1046624006873 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1046624006874 putative switch regulator; other site 1046624006875 non-specific DNA interactions [nucleotide binding]; other site 1046624006876 DNA binding site [nucleotide binding] 1046624006877 sequence specific DNA binding site [nucleotide binding]; other site 1046624006878 putative cAMP binding site [chemical binding]; other site 1046624006879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1046624006880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1046624006881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1046624006882 Ligand Binding Site [chemical binding]; other site 1046624006883 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1046624006884 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1046624006885 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1046624006886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1046624006887 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1046624006888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1046624006889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624006890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624006891 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1046624006892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1046624006893 RNA binding surface [nucleotide binding]; other site 1046624006894 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1046624006895 active site 1046624006896 uracil binding [chemical binding]; other site 1046624006897 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1046624006898 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1046624006899 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1046624006900 G1 box; other site 1046624006901 GTP/Mg2+ binding site [chemical binding]; other site 1046624006902 Switch I region; other site 1046624006903 G2 box; other site 1046624006904 Switch II region; other site 1046624006905 G3 box; other site 1046624006906 G4 box; other site 1046624006907 G5 box; other site 1046624006908 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1046624006909 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1046624006910 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1046624006911 generic binding surface II; other site 1046624006912 ssDNA binding site; other site 1046624006913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1046624006914 ATP binding site [chemical binding]; other site 1046624006915 putative Mg++ binding site [ion binding]; other site 1046624006916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1046624006917 nucleotide binding region [chemical binding]; other site 1046624006918 ATP-binding site [chemical binding]; other site 1046624006919 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1046624006920 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1046624006921 PhnA protein; Region: PhnA; pfam03831 1046624006922 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1046624006923 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1046624006924 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1046624006925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1046624006926 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1046624006927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1046624006928 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1046624006929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1046624006930 motif II; other site 1046624006931 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1046624006932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1046624006933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1046624006934 oxidoreductase; Provisional; Region: PRK06196 1046624006935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1046624006936 NAD(P) binding site [chemical binding]; other site 1046624006937 active site 1046624006938 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1046624006939 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1046624006940 23S rRNA interface [nucleotide binding]; other site 1046624006941 L3 interface [polypeptide binding]; other site 1046624006942 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1046624006943 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1046624006944 FtsX-like permease family; Region: FtsX; pfam02687 1046624006945 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1046624006946 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1046624006947 Walker A/P-loop; other site 1046624006948 ATP binding site [chemical binding]; other site 1046624006949 Q-loop/lid; other site 1046624006950 ABC transporter signature motif; other site 1046624006951 Walker B; other site 1046624006952 D-loop; other site 1046624006953 H-loop/switch region; other site 1046624006954 ribonuclease HIII; Provisional; Region: PRK00996 1046624006955 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1046624006956 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1046624006957 RNA/DNA hybrid binding site [nucleotide binding]; other site 1046624006958 active site 1046624006959 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1046624006960 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1046624006961 Catalytic site [active] 1046624006962 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1046624006963 pur operon repressor; Provisional; Region: PRK09213 1046624006964 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1046624006965 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1046624006966 active site 1046624006967 elongation factor G; Reviewed; Region: PRK00007 1046624006968 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1046624006969 G1 box; other site 1046624006970 putative GEF interaction site [polypeptide binding]; other site 1046624006971 GTP/Mg2+ binding site [chemical binding]; other site 1046624006972 Switch I region; other site 1046624006973 G2 box; other site 1046624006974 G3 box; other site 1046624006975 Switch II region; other site 1046624006976 G4 box; other site 1046624006977 G5 box; other site 1046624006978 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1046624006979 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1046624006980 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1046624006981 30S ribosomal protein S7; Validated; Region: PRK05302 1046624006982 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1046624006983 S17 interaction site [polypeptide binding]; other site 1046624006984 S8 interaction site; other site 1046624006985 16S rRNA interaction site [nucleotide binding]; other site 1046624006986 streptomycin interaction site [chemical binding]; other site 1046624006987 23S rRNA interaction site [nucleotide binding]; other site 1046624006988 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1046624006989 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1046624006990 Beta-lactamase; Region: Beta-lactamase; cl17358 1046624006991 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1046624006992 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1046624006993 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1046624006994 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1046624006995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1046624006996 FeS/SAM binding site; other site