-- dump date 20140619_125613 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_266157.1 15671983 1113599 358..1725 1 NC_002662.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1725 dnaA 1113599 dnaA Lactococcus lactis subsp. lactis Il1403 chromosomal replication initiation protein NP_266157.1 358 D 272623 CDS NP_266158.1 15671984 1113600 1882..3024 1 NC_002662.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3024 dnaN 1113600 dnaN Lactococcus lactis subsp. lactis Il1403 DNA polymerase III subunit beta NP_266158.1 1882 D 272623 CDS NP_266159.1 15671985 1113601 3130..6429 1 NC_002662.1 evidence experimental PMID:9435243; exonuclease is specifically blocked by the lactococcal Chi site (5'-GCGCGTG-3'); RexAB-mediated recombination stimulated approximately 27-fold by lactococcal Chi; subunit B of ATP-dependent exonuclease 6429 rexB 1113601 rexB Lactococcus lactis subsp. lactis Il1403 subunit B of ATP-dependent exonuclease NP_266159.1 3130 D 272623 CDS NP_266160.1 15671986 1113602 6422..10033 1 NC_002662.1 ATP-dependent exonuclease subunit a 10033 rexA 1113602 rexA Lactococcus lactis subsp. lactis Il1403 ATP-dependent exonuclease subunit a NP_266160.1 6422 D 272623 CDS NP_835283.1 30023968 1113603 10070..10270 1 NC_002662.1 hypothetical protein 10270 1113603 L200000 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835283.1 10070 D 272623 CDS NP_266161.1 15671987 1113604 complement(10280..10837) 1 NC_002662.1 belongs to the PBSX(XRE) family of transcription regulators; transcriptional regulator 10837 yabA 1113604 yabA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266161.1 10280 R 272623 CDS NP_266162.1 15671988 1113605 11119..12234 1 NC_002662.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 12234 yyaL 1113605 yyaL Lactococcus lactis subsp. lactis Il1403 GTP-dependent nucleic acid-binding protein EngD NP_266162.1 11119 D 272623 CDS NP_266163.1 15671989 1113606 12346..12669 1 NC_002662.1 belongs to the PBSX(XRE) family of transcription regulators; transcriptional regulator 12669 yabB 1113606 yabB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266163.1 12346 D 272623 CDS NP_266164.1 15671990 1113607 12924..13268 1 NC_002662.1 hypothetical protein 13268 yabC 1113607 yabC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266164.1 12924 D 272623 CDS NP_266165.1 15671991 1113608 13281..15272 1 NC_002662.1 hypothetical protein 15272 yabD 1113608 yabD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266165.1 13281 D 272623 CDS NP_266166.1 15671992 1113609 15274..15909 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 15909 yabE 1113609 yabE Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266166.1 15274 D 272623 CDS NP_266167.1 15671993 1113610 16110..16580 1 NC_002662.1 hypothetical protein 16580 yabF 1113610 yabF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266167.1 16110 D 272623 CDS NP_266168.1 15671994 1113611 16598..17164 1 NC_002662.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 17164 pth 1113611 pth Lactococcus lactis subsp. lactis Il1403 peptidyl-tRNA hydrolase NP_266168.1 16598 D 272623 CDS NP_266169.1 15671995 1113612 17165..20650 1 NC_002662.1 transcription-repair coupling factor 20650 mfd 1113612 mfd Lactococcus lactis subsp. lactis Il1403 transcription-repair coupling factor NP_266169.1 17165 D 272623 CDS NP_266170.1 15671996 1113613 20810..21280 1 NC_002662.1 hypothetical protein 21280 yacI 1113613 yacI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266170.1 20810 D 272623 CDS NP_266171.1 15671997 1113614 21351..21668 1 NC_002662.1 hypothetical protein 21668 yacB 1113614 yacB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266171.1 21351 D 272623 CDS NP_266172.1 15671998 1113615 21697..22071 1 NC_002662.1 similar to cell division protein DivIC of Bacillus subtilis; in Bacillus subtilis required for activation of genes expressed under the control of the sigma E and sigma F; hypothetical protein 22071 yacC 1113615 yacC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266172.1 21697 D 272623 CDS NP_266173.1 15671999 1113616 22071..22394 1 NC_002662.1 similar to Bacillus subtilis hypothetical 14.2 kDa protein; hypothetical protein 22394 yacD 1113616 yacD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266173.1 22071 D 272623 CDS NP_266174.1 15672000 1113617 22532..23881 1 NC_002662.1 hypothetical protein 23881 yacG 1113617 yacG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266174.1 22532 D 272623 CDS NP_266175.1 15672001 1113618 23878..25149 1 NC_002662.1 cell cycle protein; hypothetical protein 25149 mesJ 1113618 mesJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266175.1 23878 D 272623 CDS NP_266176.1 15672002 1113619 25130..25681 1 NC_002662.1 evidence experimental PMID:1465108; hypoxanthine phosphoribosyltransferase 25681 hpt 1113619 hpt Lactococcus lactis subsp. lactis Il1403 hypoxanthine phosphoribosyltransferase NP_266176.1 25130 D 272623 CDS NP_266177.1 15672003 1113620 25887..27974 1 NC_002662.1 cell division protein; evidence experimental PMID:8000529; hypothetical protein 27974 ftsH 1113620 ftsH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266177.1 25887 D 272623 CDS NP_266178.1 15672004 1113621 30922..32859 1 NC_002662.1 LysR-family regulator; probable regulator of mtl operon; LysR family transcriptional regulator 32859 mtlR 1113621 mtlR Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_266178.1 30922 D 272623 CDS NP_266179.1 15672005 1113622 32907..33338 1 NC_002662.1 transport and binding protein; PTS system; PTS system mannitol-specific transporter subunit IIA 33338 mtlF 1113622 mtlF Lactococcus lactis subsp. lactis Il1403 PTS system mannitol-specific transporter subunit IIA NP_266179.1 32907 D 272623 CDS NP_266180.1 15672006 1113623 33476..34633 1 NC_002662.1 energy metabolism; mannitol-1-phosphate 5-dehydrogenase 34633 mtlD 1113623 mtlD Lactococcus lactis subsp. lactis Il1403 mannitol-1-phosphate 5-dehydrogenase NP_266180.1 33476 D 272623 CDS NP_266181.1 15672007 1113624 complement(35516..35839) 1 NC_002662.1 similar to bacterial sigma factors; prophage ps1 protein 01 35839 ps101 1113624 ps101 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 01 NP_266181.1 35516 R 272623 CDS NP_266182.1 15672008 1113625 complement(35864..36274) 1 NC_002662.1 similar to a hypothetical protein of Lactococcus lactis subsp. cremoris S114 Y11901; prophage ps1 protein 02 36274 ps102 1113625 ps102 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 02 NP_266182.1 35864 R 272623 CDS NP_266183.1 15672009 1113626 complement(36271..36714) 1 NC_002662.1 prophage ps1 protein 03; essential for phage DNA maturation and packaging; terminase subunit 36714 ps103 1113626 ps103 Lactococcus lactis subsp. lactis Il1403 terminase subunit NP_266183.1 36271 R 272623 CDS NP_266184.1 15672010 1113627 complement(36847..37428) 1 NC_002662.1 prophage ps1 protein 04 37428 ps104 1113627 ps104 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 04 NP_266184.1 36847 R 272623 CDS NP_266185.1 15672011 1113628 complement(37664..39292) 1 NC_002662.1 prophage ps1 protein 05; similar to primase of Streptococcus thermophilus bacteriophage DT1; DNA primase 39292 ps105 1113628 ps105 Lactococcus lactis subsp. lactis Il1403 DNA primase NP_266185.1 37664 R 272623 CDS NP_266186.1 15672012 1113629 complement(39303..40097) 1 NC_002662.1 similar to Orf1 of Streptococcus thermophilus bacteriophage SFi18; prophage ps1 protein 06 40097 ps106 1113629 ps106 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 06 NP_266186.1 39303 R 272623 CDS NP_266187.1 15672013 1113630 complement(40101..40430) 1 NC_002662.1 prophage ps1 protein 07 40430 ps107 1113630 ps107 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 07 NP_266187.1 40101 R 272623 CDS NP_835284.1 30023969 1113631 complement(40417..40611) 1 NC_002662.1 prophage ps2 protein 12 40611 1113631 L200001 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 12 NP_835284.1 40417 R 272623 CDS NP_266188.1 15672014 1113632 complement(40608..40862) 1 NC_002662.1 prophage ps1 protein 08 40862 ps108 1113632 ps108 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 08 NP_266188.1 40608 R 272623 CDS NP_266189.1 15672015 1113633 complement(40859..41098) 1 NC_002662.1 prophage ps1 protein 09 41098 ps109 1113633 ps109 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 09 NP_266189.1 40859 R 272623 CDS NP_266190.1 15672016 1113634 complement(41141..41422) 1 NC_002662.1 prophage ps1 protein 10 41422 ps110 1113634 ps110 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 10 NP_266190.1 41141 R 272623 CDS NP_266191.1 15672017 1113635 complement(41419..41670) 1 NC_002662.1 PBSX(XRE) family of transcription regulators; prophage ps1 protein 11 41670 ps111 1113635 ps111 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 11 NP_266191.1 41419 R 272623 CDS NP_266192.1 15672018 1113636 complement(41667..42188) 1 NC_002662.1 similar to a DNA polymerase of Neurospora crassa mitochondrion plasmid maranhar; prophage ps1 protein 12 42188 ps112 1113636 ps112 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 12 NP_266192.1 41667 R 272623 CDS NP_266193.1 15672019 1113637 complement(42192..42386) 1 NC_002662.1 prophage ps1 protein 13 42386 ps113 1113637 ps113 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 13 NP_266193.1 42192 R 272623 CDS NP_266194.1 15672020 1113638 complement(42462..43202) 1 NC_002662.1 similar to Rha protein of Escherichia coli phage phi-80; prophage ps1 protein 14 43202 ps114 1113638 ps114 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 14 NP_266194.1 42462 R 272623 CDS NP_835285.1 30023970 1113639 complement(43231..43407) 1 NC_002662.1 bacteriophage bIL310 repressor 43407 1113639 L200002 Lactococcus lactis subsp. lactis Il1403 bacteriophage bIL310 repressor NP_835285.1 43231 R 272623 CDS NP_266195.1 15672021 1113640 43689..44075 1 NC_002662.1 transcription regulator; similar to Rad protein of Lactobacillus bacteriophage phi adh; prophage ps1 protein 15 44075 ps115 1113640 ps115 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 15 NP_266195.1 43689 D 272623 CDS NP_266196.1 15672022 1113641 44085..44639 1 NC_002662.1 prophage ps1 protein 16 44639 ps116 1113641 ps116 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 16 NP_266196.1 44085 D 272623 CDS NP_266197.1 15672023 1113642 44750..44980 1 NC_002662.1 prophage ps1 protein 17 44980 ps117 1113642 ps117 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 17 NP_266197.1 44750 D 272623 CDS NP_266198.1 15672024 1113643 45053..45247 1 NC_002662.1 hypothetical protein 45247 ps118 1113643 ps118 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266198.1 45053 D 272623 CDS NP_266199.1 15672025 1113644 45399..45641 1 NC_002662.1 prophage ps1 protein 19 45641 ps119 1113644 ps119 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 19 NP_266199.1 45399 D 272623 CDS NP_266200.1 15672026 1113645 45777..46001 1 NC_002662.1 prophage ps1 protein 20 46001 ps120 1113645 ps120 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 20 NP_266200.1 45777 D 272623 CDS NP_835286.1 30023971 1113646 46648..46794 1 NC_002662.1 hypothetical protein 46794 1113646 L200003 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835286.1 46648 D 272623 CDS NP_266201.1 15672027 1113647 47370..47585 1 NC_002662.1 prophage ps1 protein 21 47585 ps121 1113647 ps121 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 21 NP_266201.1 47370 D 272623 CDS NP_835287.1 30023972 1113648 47702..47866 1 NC_002662.1 bacteriophage bIL310 Orf3 47866 1113648 L200004 Lactococcus lactis subsp. lactis Il1403 bacteriophage bIL310 Orf3 NP_835287.1 47702 D 272623 CDS NP_266202.1 15672028 1113649 47988..48293 1 NC_002662.1 similar to lactococcin A immunity protein; prophage ps1 protein 22 48293 ps122 1113649 ps122 Lactococcus lactis subsp. lactis Il1403 prophage ps1 protein 22 NP_266202.1 47988 D 272623 CDS NP_266203.1 15672029 1113650 48543..49727 1 NC_002662.1 prophage ps1 protein 23; integrase 49727 ps123 1113650 ps123 Lactococcus lactis subsp. lactis Il1403 integrase NP_266203.1 48543 D 272623 CDS NP_266204.1 15672030 1113651 50180..50629 1 NC_002662.1 paralogous to yfhA; hypothetical protein 50629 yafE 1113651 yafE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266204.1 50180 D 272623 CDS NP_266205.1 15672031 1113652 50706..50948 1 NC_002662.1 hypothetical protein 50948 yafF 1113652 yafF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266205.1 50706 D 272623 CDS NP_266206.1 15672032 1113653 complement(51029..52411) 1 NC_002662.1 transport and binding protein, anions; similar to several sulfate transporters; sulfate transporter 52411 yafB 1113653 yafB Lactococcus lactis subsp. lactis Il1403 sulfate transporter NP_266206.1 51029 R 272623 CDS NP_266208.1 15672034 1113655 53161..53844 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; IS1077A transposase 53844 1113655 L0466 Lactococcus lactis subsp. lactis Il1403 IS1077A transposase NP_266208.1 53161 D 272623 CDS NP_266209.1 15672035 1113656 complement(53900..54661) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904A 54661 tra904A 1113656 tra904A Lactococcus lactis subsp. lactis Il1403 transposase of IS904A NP_266209.1 53900 R 272623 CDS NP_266210.1 15672036 1113657 complement(54757..55047) 1 NC_002662.1 transposon related function; hypothetical protein 55047 yafI 1113657 yafI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266210.1 54757 R 272623 CDS NP_266211.1 15672037 1113658 complement(55126..55389) 1 NC_002662.1 similar to hypothetical protein YvdB from Bacillus subtilis; hypothetical protein 55389 yafJ 1113658 yafJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266211.1 55126 R 272623 CDS NP_266212.1 15672038 1113659 55599..56120 1 NC_002662.1 hypothetical protein 56120 yafC 1113659 yafC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266212.1 55599 D 272623 CDS NP_266213.1 15672039 1113660 56584..57759 1 NC_002662.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 57759 araT 1113660 araT Lactococcus lactis subsp. lactis Il1403 aromatic amino acid aminotransferase NP_266213.1 56584 D 272623 CDS NP_266214.1 15672040 1113661 57858..58613 1 NC_002662.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 58613 recO 1113661 recO Lactococcus lactis subsp. lactis Il1403 DNA repair protein RecO NP_266214.1 57858 D 272623 CDS NP_266215.1 15672041 1113662 complement(58971..60389) 1 NC_002662.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 60389 pdhD 1113662 pdhD Lactococcus lactis subsp. lactis Il1403 dihydrolipoamide dehydrogenase NP_266215.1 58971 R 272623 CDS NP_266216.1 15672042 1113663 complement(60583..62181) 1 NC_002662.1 pyruvate dehydrogenase; dihydrolipoamide acetyltransferase component of PDH complex 62181 pdhC 1113663 pdhC Lactococcus lactis subsp. lactis Il1403 dihydrolipoamide acetyltransferase component of PDH complex NP_266216.1 60583 R 272623 CDS NP_266217.1 15672043 1113664 complement(62174..63154) 1 NC_002662.1 pyruvate dehydrogenase; PDH E1 component subunit beta 63154 pdhB 1113664 pdhB Lactococcus lactis subsp. lactis Il1403 PDH E1 component subunit beta NP_266217.1 62174 R 272623 CDS NP_266218.1 15672044 1113665 complement(63157..64281) 1 NC_002662.1 pyruvate dehydrogenase; PDH E1 component subunit alpha 64281 pdhA 1113665 pdhA Lactococcus lactis subsp. lactis Il1403 PDH E1 component subunit alpha NP_266218.1 63157 R 272623 CDS NP_266219.1 15672045 1113666 complement(64370..65371) 1 NC_002662.1 lipoate-protein ligase 65371 lplL 1113666 lplL Lactococcus lactis subsp. lactis Il1403 lipoate-protein ligase NP_266219.1 64370 R 272623 CDS NP_266220.1 15672046 1113667 complement(65571..66416) 1 NC_002662.1 similar to glycerophosphoryl diester phosphodiesterases; hypothetical protein 66416 yagA 1113667 yagA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266220.1 65571 R 272623 CDS NP_266221.1 15672047 1113668 complement(66497..67147) 1 NC_002662.1 exists in AT rich gram positives and in archae; hypothetical protein 67147 yagB 1113668 yagB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266221.1 66497 R 272623 CDS NP_266222.1 15672048 1113669 complement(67264..68289) 1 NC_002662.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 68289 trpS 1113669 trpS Lactococcus lactis subsp. lactis Il1403 tryptophanyl-tRNA synthetase II NP_266222.1 67264 R 272623 CDS NP_266223.1 15672049 1113670 68791..69228 1 NC_002662.1 adaptations and atypical conditions; similar to osmotically inducible protein OsmC of Escherichia coli; osmotically inducible protein 69228 osmC 1113670 osmC Lactococcus lactis subsp. lactis Il1403 osmotically inducible protein NP_266223.1 68791 D 272623 CDS NP_266224.1 15672050 1113671 69389..70702 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 70702 yagE 1113671 yagE Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_266224.1 69389 D 272623 CDS NP_266225.1 15672051 1113672 70762..71112 1 NC_002662.1 hypothetical protein 71112 yahC 1113672 yahC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266225.1 70762 D 272623 CDS NP_266226.1 15672052 1113673 complement(71171..72166) 1 NC_002662.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 72166 plsX 1113673 plsX Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphate acyltransferase PlsX NP_266226.1 71171 R 272623 CDS NP_266227.1 15672053 1113674 complement(72269..73081) 1 NC_002662.1 hypothetical protein 73081 yahA 1113674 yahA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266227.1 72269 R 272623 CDS NP_266228.1 15672054 1113675 complement(73207..74844) 1 NC_002662.1 transport and binding protein; contains two ATP binding domains; ABC transporter ATP-binding protein 74844 yahG 1113675 yahG Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266228.1 73207 R 272623 CDS NP_266229.1 15672055 1113676 complement(75972..77252) 1 NC_002662.1 O-acetylhomoserine sulfhydrylase 77252 cysD 1113676 cysD Lactococcus lactis subsp. lactis Il1403 O-acetylhomoserine sulfhydrylase NP_266229.1 75972 R 272623 CDS NP_266230.1 15672056 1113677 complement(77479..78312) 1 NC_002662.1 aerobic energy metabolism; short-chain type dehydrogenase 78312 yahI 1113677 yahI Lactococcus lactis subsp. lactis Il1403 short-chain type dehydrogenase NP_266230.1 77479 R 272623 CDS NP_266231.1 15672057 1113678 78713..79180 1 NC_002662.1 hypothetical protein 79180 yahB 1113678 yahB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266231.1 78713 D 272623 CDS NP_835288.1 30023973 1113679 79309..79506 1 NC_002662.1 hypothetical protein 79506 1113679 L200005 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835288.1 79309 D 272623 CDS NP_266232.1 15672058 1113680 79537..80157 1 NC_002662.1 hypothetical protein 80157 yahD 1113680 yahD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266232.1 79537 D 272623 CDS NP_266233.1 15672059 1113681 80208..81377 1 NC_002662.1 hypothetical protein 81377 yaiA 1113681 yaiA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266233.1 80208 D 272623 CDS NP_266234.1 15672060 1113682 81388..81978 1 NC_002662.1 hypothetical protein 81978 yaiB 1113682 yaiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266234.1 81388 D 272623 CDS NP_266235.1 15672061 1113683 82576..84723 1 NC_002662.1 lactococcin A ABC transporter ATP-binding protein/permease 84723 lcnC 1113683 lcnC Lactococcus lactis subsp. lactis Il1403 lactococcin A ABC transporter ATP-binding protein/permease NP_266235.1 82576 D 272623 CDS NP_266236.1 15672062 1113684 84738..86159 1 NC_002662.1 evidence experimental PMID:8633867; transport and binding protein; multidrug resistance; in the strain diacetylactis WM4 involved in secretion of lactococcin A; HlyD family of secretion proteins; lactococcin A ABC transporter permease 86159 lcnD 1113684 lcnD Lactococcus lactis subsp. lactis Il1403 lactococcin A ABC transporter permease NP_266236.1 84738 D 272623 CDS NP_266237.1 15672063 1113685 86620..87072 1 NC_002662.1 transport and binding protein; transporter 87072 yaiE 1113685 yaiE Lactococcus lactis subsp. lactis Il1403 transporter NP_266237.1 86620 D 272623 CDS NP_266238.1 15672064 1113686 87111..87767 1 NC_002662.1 hypothetical protein 87767 yaiF 1113686 yaiF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266238.1 87111 D 272623 CDS NP_266239.1 15672065 1113687 complement(87870..88151) 1 NC_002662.1 hypothetical protein 88151 yaiI 1113687 yaiI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266239.1 87870 R 272623 CDS NP_835289.1 30023974 1113688 complement(88161..88313) 1 NC_002662.1 hypothetical protein 88313 yaiJ 1113688 yaiJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835289.1 88161 R 272623 CDS NP_266240.1 15672066 1113689 88652..88870 1 NC_002662.1 similar to LcnD of Lactococcus lactis; hypothetical protein 88870 yaiG 1113689 yaiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266240.1 88652 D 272623 CDS NP_266241.1 15672067 1113690 89117..89827 1 NC_002662.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653; hypothetical protein 89827 yaiH 1113690 yaiH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266241.1 89117 D 272623 CDS NP_266242.1 15672068 1113691 90253..90705 1 NC_002662.1 transport and binding protein; similar to several membrane proteins; transporter 90705 yajA 1113691 yajA Lactococcus lactis subsp. lactis Il1403 transporter NP_266242.1 90253 D 272623 CDS NP_266243.1 15672069 1113692 complement(91052..91891) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981A 91891 tra981A 1113692 tra981A Lactococcus lactis subsp. lactis Il1403 transposase of IS981A NP_266243.1 91052 R 272623 CDS NP_266244.1 15672070 1113693 complement(91903..92163) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 92163 yajE 1113693 yajE Lactococcus lactis subsp. lactis Il1403 transposase NP_266244.1 91903 R 272623 CDS NP_266245.1 15672071 1113694 complement(92200..92805) 1 NC_002662.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653; hypothetical protein 92805 yajF 1113694 yajF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266245.1 92200 R 272623 CDS YP_008998699.1 574739638 18245207 complement(93031..93621) 1 NC_002662.1 transposase 93621 18245207 L92205a Lactococcus lactis subsp. lactis Il1403 transposase YP_008998699.1 93031 R 272623 CDS NP_266246.1 15672072 1113696 complement(93882..94142) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 94142 yajG 1113696 yajG Lactococcus lactis subsp. lactis Il1403 transposase NP_266246.1 93882 R 272623 CDS NP_266247.1 15672073 1113697 94253..94621 1 NC_002662.1 hypothetical protein 94621 yajB 1113697 yajB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266247.1 94253 D 272623 CDS NP_266248.1 15672074 1113698 complement(94841..95143) 1 NC_002662.1 hypothetical protein 95143 yajH 1113698 yajH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266248.1 94841 R 272623 CDS NP_266249.1 15672075 1113699 complement(95879..96028) 1 NC_002662.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 96028 rpmG 1113699 rpmG Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L33 NP_266249.1 95879 R 272623 CDS NP_266250.1 15672076 1113700 complement(96058..96231) 1 NC_002662.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 96231 rpmF 1113700 rpmF Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L32 NP_266250.1 96058 R 272623 CDS NP_266251.1 15672077 1113701 96595..98376 1 NC_002662.1 transort and binding protein, cations; cation transport ATPase family (E1-E2 ATPase); cadmium efflux ATPase 98376 cadA 1113701 cadA Lactococcus lactis subsp. lactis Il1403 cadmium efflux ATPase NP_266251.1 96595 D 272623 CDS NP_266252.1 15672078 1113702 complement(98429..99214) 1 NC_002662.1 chromosome partitioning protein 99214 parA 1113702 parA Lactococcus lactis subsp. lactis Il1403 chromosome partitioning protein NP_266252.1 98429 R 272623 CDS NP_266253.1 15672079 1113703 complement(99269..100528) 1 NC_002662.1 recombination factor protein RarA 100528 cshA 1113703 cshA Lactococcus lactis subsp. lactis Il1403 recombination factor protein RarA NP_266253.1 99269 R 272623 CDS NP_266254.1 15672080 1113704 complement(100572..101060) 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; acetyl transferase 101060 ybaH 1113704 ybaH Lactococcus lactis subsp. lactis Il1403 acetyl transferase NP_266254.1 100572 R 272623 CDS NP_266255.1 15672081 1113705 101212..101679 1 NC_002662.1 hypothetical protein 101679 ybaA 1113705 ybaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266255.1 101212 D 272623 CDS NP_266256.1 15672082 1113706 101709..103262 1 NC_002662.1 transport and binding protein; contains two ATP binding domains; ABC transporter ATP-binding protein 103262 ybaB 1113706 ybaB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266256.1 101709 D 272623 CDS NP_266257.1 15672083 1113707 103393..103677 1 NC_002662.1 hypothetical protein 103677 ybaC 1113707 ybaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266257.1 103393 D 272623 CDS NP_266258.1 15672084 1113708 103715..104203 1 NC_002662.1 hypothetical protein 104203 ybaD 1113708 ybaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266258.1 103715 D 272623 CDS NP_266259.1 15672085 1113709 104221..105174 1 NC_002662.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 105174 prmA 1113709 prmA Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L11 methyltransferase NP_266259.1 104221 D 272623 CDS NP_266260.1 15672086 1113710 105274..106026 1 NC_002662.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 106026 ybaF 1113710 ybaF Lactococcus lactis subsp. lactis Il1403 16S ribosomal RNA methyltransferase RsmE NP_266260.1 105274 D 272623 CDS NP_266261.1 15672087 1113711 106055..107011 1 NC_002662.1 hypothetical protein 107011 ybaG 1113711 ybaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266261.1 106055 D 272623 CDS NP_266262.1 15672088 1113712 107212..109434 1 NC_002662.1 general regulatory function; ppGpp synthetase I 109434 relA 1113712 relA Lactococcus lactis subsp. lactis Il1403 ppGpp synthetase I NP_266262.1 107212 D 272623 CDS NP_266263.1 15672089 1113713 complement(109450..110385) 1 NC_002662.1 glycosyltransferase family 2; glycosyl transferase 110385 ybaI 1113713 ybaI Lactococcus lactis subsp. lactis Il1403 glycosyl transferase NP_266263.1 109450 R 272623 CDS NP_266264.1 15672090 1113714 110576..111031 1 NC_002662.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 111031 ybbA 1113714 ybbA Lactococcus lactis subsp. lactis Il1403 D-tyrosyl-tRNA(Tyr) deacylase NP_266264.1 110576 D 272623 CDS NP_266265.1 15672091 1113715 111024..112019 1 NC_002662.1 hypothetical protein 112019 ybbB 1113715 ybbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266265.1 111024 D 272623 CDS NP_266266.1 15672092 1113716 112022..112645 1 NC_002662.1 hypothetical protein 112645 ybbC 1113716 ybbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266266.1 112022 D 272623 CDS NP_266267.1 15672093 1113717 112785..114194 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many cationic amino acid transporters; cationic amino acid transporter 114194 ctrA 1113717 ctrA Lactococcus lactis subsp. lactis Il1403 cationic amino acid transporter NP_266267.1 112785 D 272623 CDS NP_266268.1 15672094 1113718 114343..114984 1 NC_002662.1 hypothetical protein 114984 ybbE 1113718 ybbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266268.1 114343 D 272623 CDS NP_266269.1 15672095 1113719 complement(115022..115513) 1 NC_002662.1 MarR-family regulator; transcriptional regulator 115513 rmaD 1113719 rmaD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266269.1 115022 R 272623 CDS NP_266270.1 15672096 1113720 complement(115548..116192) 1 NC_002662.1 converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP; probable NAD(P)H dehydrogenase; ACP phosphodiesterase 116192 acpD 1113720 acpD Lactococcus lactis subsp. lactis Il1403 ACP phosphodiesterase NP_266270.1 115548 R 272623 CDS NP_266271.1 15672097 1113721 116366..118963 1 NC_002662.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 118963 secA 1113721 secA Lactococcus lactis subsp. lactis Il1403 preprotein translocase subunit SecA NP_266271.1 116366 D 272623 CDS NP_266272.1 15672098 1113722 119092..120129 1 NC_002662.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 120129 aroF 1113722 aroF Lactococcus lactis subsp. lactis Il1403 phospho-2-dehydro-3-deoxyheptonate aldolase NP_266272.1 119092 D 272623 CDS NP_266273.1 15672099 1113723 120380..120646 1 NC_002662.1 transport and binding protein; PTS system; phosphocarrier protein HPr 120646 ptsH 1113723 ptsH Lactococcus lactis subsp. lactis Il1403 phosphocarrier protein HPr NP_266273.1 120380 D 272623 CDS NP_266274.1 15672100 1113724 120649..122376 1 NC_002662.1 transport and binding protein; PTS system; PTS system enzyme I; phosphoenolpyruvate-protein phosphotransferase 122376 ptsI 1113724 ptsI Lactococcus lactis subsp. lactis Il1403 phosphoenolpyruvate-protein phosphotransferase NP_266274.1 120649 D 272623 CDS NP_266275.1 15672101 1113725 122491..122805 1 NC_002662.1 hypothetical protein 122805 ybcC 1113725 ybcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266275.1 122491 D 272623 CDS NP_266276.1 15672102 1113726 complement(122846..123145) 1 NC_002662.1 hypothetical protein 123145 ybcG 1113726 ybcG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266276.1 122846 R 272623 CDS NP_266277.1 15672103 1113727 complement(123533..124468) 1 NC_002662.1 hypothetical protein 124468 ybcH 1113727 ybcH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266277.1 123533 R 272623 CDS NP_266278.1 15672104 1113728 124677..125030 1 NC_002662.1 chaperones; SugE protein 125030 sugE 1113728 sugE Lactococcus lactis subsp. lactis Il1403 SugE protein NP_266278.1 124677 D 272623 CDS NP_266279.1 15672105 1113729 125152..126315 1 NC_002662.1 multidrug resistance; multidrug efflux transporter 126315 blt 1113729 blt Lactococcus lactis subsp. lactis Il1403 multidrug efflux transporter NP_266279.1 125152 D 272623 CDS NP_266280.2 30023975 1113730 126757..127950 1 NC_002662.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 127950 argG 1113730 argG Lactococcus lactis subsp. lactis Il1403 argininosuccinate synthase NP_266280.2 126757 D 272623 CDS NP_266281.1 15672107 1113731 127981..129360 1 NC_002662.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 129360 argH 1113731 argH Lactococcus lactis subsp. lactis Il1403 argininosuccinate lyase NP_266281.1 127981 D 272623 CDS NP_266282.1 15672108 1113732 complement(129376..130572) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to PmrA of Streptococcus pneumoniae; multidrug resistance efflux pump 130572 pmrB 1113732 pmrB Lactococcus lactis subsp. lactis Il1403 multidrug resistance efflux pump NP_266282.1 129376 R 272623 CDS NP_266283.1 15672109 1113733 130767..131342 1 NC_002662.1 similar to Escherichia coli tetracycline repressor protein; transcriptional regulator 131342 ybdA 1113733 ybdA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266283.1 130767 D 272623 CDS NP_266284.1 15672110 1113734 131494..131847 1 NC_002662.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 131847 rnpA 1113734 rnpA Lactococcus lactis subsp. lactis Il1403 ribonuclease P NP_266284.1 131494 D 272623 CDS NP_266285.1 15672111 1113735 131844..132653 1 NC_002662.1 similar to SpoIIIJ protein of Bacillus subtilis; attached to membrane by a lipid anchor; hypothetical protein 132653 ybdC 1113735 ybdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266285.1 131844 D 272623 CDS NP_266286.1 15672112 1113736 132742..133656 1 NC_002662.1 similar to spoIIIJ-associated protein Jag protein from differenr species; hypothetical protein 133656 ybdD 1113736 ybdD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266286.1 132742 D 272623 CDS NP_266287.1 15672113 1113737 133788..133922 1 NC_002662.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 133922 rpmH 1113737 rpmH Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L34 NP_266287.1 133788 D 272623 CDS NP_266288.1 15672114 1113739 135110..135430 1 NC_002662.1 belongs to the PBSX(XRE) family of transcription regulators; transcriptional regulator 135430 ybdG 1113739 ybdG Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266288.1 135110 D 272623 CDS NP_266289.1 15672115 1113740 135561..135788 1 NC_002662.1 hypothetical protein 135788 ybdH 1113740 ybdH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266289.1 135561 D 272623 CDS NP_266290.1 15672116 1113741 135966..136511 1 NC_002662.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653; hypothetical protein 136511 ybdI 1113741 ybdI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266290.1 135966 D 272623 CDS NP_266291.1 15672117 1113742 136564..137244 1 NC_002662.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653; hypothetical protein 137244 ybdJ 1113742 ybdJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266291.1 136564 D 272623 CDS NP_266292.1 15672118 1113743 137413..137703 1 NC_002662.1 transposon related function; hypothetical protein 137703 ybdK 1113743 ybdK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266292.1 137413 D 272623 CDS NP_266293.1 15672119 1113744 137799..138560 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904B 138560 tra904B 1113744 tra904B Lactococcus lactis subsp. lactis Il1403 transposase of IS904B NP_266293.1 137799 D 272623 CDS NP_266294.1 15672120 1113745 138617..139174 1 NC_002662.1 transposon related function; hypothetical protein 139174 ybdL 1113745 ybdL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266294.1 138617 D 272623 CDS NP_266295.1 15672121 1113746 139171..139989 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; IS1077B transposase 139989 tra1077B 1113746 tra1077B Lactococcus lactis subsp. lactis Il1403 IS1077B transposase NP_266295.1 139171 D 272623 CDS NP_266296.1 15672122 1113747 complement(140045..140806) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904C 140806 tra904C 1113747 tra904C Lactococcus lactis subsp. lactis Il1403 transposase of IS904C NP_266296.1 140045 R 272623 CDS NP_266297.1 15672123 1113748 complement(140902..141192) 1 NC_002662.1 transposon related function; hypothetical protein 141192 ybeG 1113748 ybeG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266297.1 140902 R 272623 CDS NP_266298.1 15672124 1113749 141497..141763 1 NC_002662.1 hypothetical protein 141763 ybeA 1113749 ybeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266298.1 141497 D 272623 CDS NP_266299.1 15672125 1113750 141835..142194 1 NC_002662.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 142194 ybeB 1113750 ybeB Lactococcus lactis subsp. lactis Il1403 Holliday junction resolvase-like protein NP_266299.1 141835 D 272623 CDS NP_266300.1 15672126 1113751 142347..142670 1 NC_002662.1 similar to YrzB of Bacillus subtilis; hypothetical protein 142670 ybeC 1113751 ybeC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266300.1 142347 D 272623 CDS NP_266301.1 15672127 1113752 complement(142701..143252) 1 NC_002662.1 hypothetical protein 143252 ybeH 1113752 ybeH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266301.1 142701 R 272623 CDS NP_266302.1 15672128 1113753 complement(143347..144132) 1 NC_002662.1 aerobic energy metabolism; short-chain dehydrogenases/reductases family; carbonyl reductase 144132 cbr 1113753 cbr Lactococcus lactis subsp. lactis Il1403 carbonyl reductase NP_266302.1 143347 R 272623 CDS NP_266303.1 15672129 1113754 complement(144152..144397) 1 NC_002662.1 hypothetical protein 144397 ybeI 1113754 ybeI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266303.1 144152 R 272623 CDS NP_266304.1 15672130 1113755 complement(144407..145192) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; short-chain dehydrogenase/reductase family; oxidoreductase 145192 dltE 1113755 dltE Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266304.1 144407 R 272623 CDS NP_266305.1 15672131 1113756 145304..145849 1 NC_002662.1 TetR/AcrR family of transcription regulators; transcriptional regulator 145849 ybeD 1113756 ybeD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266305.1 145304 D 272623 CDS NP_266306.1 15672132 1113758 complement(148003..148323) 1 NC_002662.1 hypothetical protein 148323 ybeM 1113758 ybeM Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266306.1 148003 R 272623 CDS NP_266307.1 15672133 1113759 148795..154746 1 NC_002662.1 hypothetical protein 154746 ybeF 1113759 ybeF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266307.1 148795 D 272623 CDS NP_266308.1 15672134 1113760 complement(155375..156523) 1 NC_002662.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 156523 tgt 1113760 tgt Lactococcus lactis subsp. lactis Il1403 queuine tRNA-ribosyltransferase NP_266308.1 155375 R 272623 CDS NP_266309.1 15672135 1113761 156715..157407 1 NC_002662.1 hypothetical protein 157407 ybfA 1113761 ybfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266309.1 156715 D 272623 CDS NP_266310.1 15672136 1113762 complement(157468..158649) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to several quinolene resistance proteins NorA; transporter 158649 ybfD 1113762 ybfD Lactococcus lactis subsp. lactis Il1403 transporter NP_266310.1 157468 R 272623 CDS NP_266311.1 15672137 1113763 complement(158830..159267) 1 NC_002662.1 hypothetical protein 159267 ybfE 1113763 ybfE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266311.1 158830 R 272623 CDS NP_266312.1 15672138 1113764 159402..160193 1 NC_002662.1 similar to streptodornase (DNAse) from Streptococcus pyogenes; hypothetical protein 160193 ybfB 1113764 ybfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266312.1 159402 D 272623 CDS NP_266313.1 15672139 1113765 160358..160567 1 NC_002662.1 hypothetical protein 160567 ybfC 1113765 ybfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266313.1 160358 D 272623 CDS NP_266314.1 15672140 1113766 160579..160818 1 NC_002662.1 hypothetical protein 160818 ybgA 1113766 ybgA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266314.1 160579 D 272623 CDS NP_266315.1 15672141 1113767 161014..162597 1 NC_002662.1 hypothetical protein 162597 ybgB 1113767 ybgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266315.1 161014 D 272623 CDS NP_266316.1 15672142 1113768 162666..163880 1 NC_002662.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 163880 aspC 1113768 aspC Lactococcus lactis subsp. lactis Il1403 aminotransferase AlaT NP_266316.1 162666 D 272623 CDS NP_266317.1 15672143 1113769 164033..164821 1 NC_002662.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 164821 codY 1113769 codY Lactococcus lactis subsp. lactis Il1403 transcriptional repressor CodY NP_266317.1 164033 D 272623 CDS NP_266318.1 15672144 1113770 165330..165635 1 NC_002662.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 165635 gatC 1113770 gatC Lactococcus lactis subsp. lactis Il1403 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_266318.1 165330 D 272623 CDS NP_266319.1 15672145 1113771 165635..167095 1 NC_002662.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 167095 gatA 1113771 gatA Lactococcus lactis subsp. lactis Il1403 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_266319.1 165635 D 272623 CDS NP_266320.1 15672146 1113772 167099..167701 1 NC_002662.1 similar to several MutT-like proteins; hypothetical protein 167701 ybgD 1113772 ybgD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266320.1 167099 D 272623 CDS NP_266321.2 30023976 1113773 167741..169174 1 NC_002662.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 169174 gatB 1113773 gatB Lactococcus lactis subsp. lactis Il1403 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_266321.2 167741 D 272623 CDS NP_266322.1 15672148 1113774 169398..170897 1 NC_002662.1 similar to 6-aminohexanoate-cyclic-dimer hydrolase of Flavobacterium sp.; amidase 170897 ybgE 1113774 ybgE Lactococcus lactis subsp. lactis Il1403 amidase NP_266322.1 169398 D 272623 CDS NP_266323.1 15672149 1113775 complement(170979..172319) 1 NC_002662.1 damage-inducible protein; adaptations and atypical conditions; similar to DinF protein from Streptococcus pneumoniae; DinF 172319 dinF 1113775 dinF Lactococcus lactis subsp. lactis Il1403 DinF NP_266323.1 170979 R 272623 CDS NP_266324.1 15672150 1113776 complement(172501..172698) 1 NC_002662.1 adaptations and atypical conditions; cold-shock (CSD) family; cold shock protein E 172698 cspE 1113776 cspE Lactococcus lactis subsp. lactis Il1403 cold shock protein E NP_266324.1 172501 R 272623 CDS NP_266325.1 15672151 1113777 172816..173349 1 NC_002662.1 similar to 5-formyltetrahydrofolate cyclo-ligase; hypothetical protein 173349 ybhA 1113777 ybhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266325.1 172816 D 272623 CDS NP_266326.1 15672152 1113778 173339..174031 1 NC_002662.1 hypothetical protein 174031 ybhB 1113778 ybhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266326.1 173339 D 272623 CDS NP_266327.1 15672153 1113779 174131..174562 1 NC_002662.1 hypothetical protein 174562 ybhC 1113779 ybhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266327.1 174131 D 272623 CDS NP_266328.1 15672154 1113780 174953..176005 1 NC_002662.1 hypothetical protein 176005 ybhD 1113780 ybhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266328.1 174953 D 272623 CDS NP_266329.1 15672155 1113781 176338..177432 1 NC_002662.1 similar to outer surface protein of Borrelia burgdorferi; hypothetical protein 177432 ybhE 1113781 ybhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266329.1 176338 D 272623 CDS NP_266330.1 15672156 1113782 177530..179014 1 NC_002662.1 transport and binding protein; PTS system; PTS system cellobiose-specific transporter subunit IIC 179014 celB 1113782 celB Lactococcus lactis subsp. lactis Il1403 PTS system cellobiose-specific transporter subunit IIC NP_266330.1 177530 D 272623 CDS NP_835290.1 30023977 1113783 179139..179345 1 NC_002662.1 hypothetical protein 179345 1113783 L200010 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835290.1 179139 D 272623 CDS NP_266331.1 15672157 1113784 179668..181104 1 NC_002662.1 energy metabolism, sugars; beta-glucosidase A 181104 bglS 1113784 bglS Lactococcus lactis subsp. lactis Il1403 beta-glucosidase A NP_266331.1 179668 D 272623 CDS NP_266332.1 15672158 1113785 181168..181620 1 NC_002662.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 181620 dut 1113785 dut Lactococcus lactis subsp. lactis Il1403 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_266332.1 181168 D 272623 CDS NP_266333.1 15672159 1113786 181873..183216 1 NC_002662.1 similar to several 5'-nucleotidases; hypothetical protein 183216 ybiB 1113786 ybiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266333.1 181873 D 272623 CDS NP_266334.1 15672160 1113787 183231..183986 1 NC_002662.1 similar to YutD of Bacillus subtilis; hypothetical protein 183986 ybiC 1113787 ybiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266334.1 183231 D 272623 CDS NP_266335.1 15672161 1113788 184180..185277 1 NC_002662.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 185277 ybiD 1113788 ybiD Lactococcus lactis subsp. lactis Il1403 ribosomal RNA large subunit methyltransferase N NP_266335.1 184180 D 272623 CDS NP_266336.1 15672162 1113789 185523..186134 1 NC_002662.1 aerobic energy metabolism; similar to different oxidoreductases; oxidoreductase 186134 ybiE 1113789 ybiE Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266336.1 185523 D 272623 CDS NP_266337.1 15672163 1113790 186285..187265 1 NC_002662.1 prenyl transferase 187265 preA 1113790 preA Lactococcus lactis subsp. lactis Il1403 prenyl transferase NP_266337.1 186285 D 272623 CDS NP_266338.1 15672164 1113791 187459..188364 1 NC_002662.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 188364 ybiG 1113791 ybiG Lactococcus lactis subsp. lactis Il1403 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_266338.1 187459 D 272623 CDS NP_266342.1 15672168 1113795 complement(189816..190016) 1 NC_002662.1 hypothetical protein 190016 ybiK 1113795 ybiK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266342.1 189816 R 272623 CDS NP_266343.1 15672169 1113796 complement(190003..192132) 1 NC_002662.1 transport and binding protein, cations; GTP-driven transporter of ferrous ion; ferrous ion transport protein B 192132 feoB 1113796 feoB Lactococcus lactis subsp. lactis Il1403 ferrous ion transport protein B NP_266343.1 190003 R 272623 CDS NP_266344.2 30023978 1113797 complement(192234..192710) 1 NC_002662.1 transport and binding protein, cations; ferrous ion transport protein A 192710 feoA 1113797 feoA Lactococcus lactis subsp. lactis Il1403 ferrous ion transport protein A NP_266344.2 192234 R 272623 CDS NP_266345.1 15672171 1113798 193029..193457 1 NC_002662.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 193457 ybjA 1113798 ybjA Lactococcus lactis subsp. lactis Il1403 methionine sulfoxide reductase B NP_266345.1 193029 D 272623 CDS NP_266346.2 30023979 1113799 complement(193587..195251) 1 NC_002662.1 similar to hypothetical protein YloV from Bacillus subtilis; probable kinase related to hydroxyacetone kinase, evidenced by COGnitor; hypothetical protein 195251 ybjJ 1113799 ybjJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266346.2 193587 R 272623 CDS NP_266347.1 15672173 1113800 complement(195251..195619) 1 NC_002662.1 similar to Asp23 protein of Bacillus subtilis encoded by yloU gene; conserved hypothetical akaline shock protein; hypothetical protein 195619 ybjK 1113800 ybjK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266347.1 195251 R 272623 CDS NP_266348.1 15672174 1113801 complement(195892..196086) 1 NC_002662.1 required for 70S ribosome assembly; 50S ribosomal protein L28 196086 rpmB 1113801 rpmB Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L28 NP_266348.1 195892 R 272623 CDS NP_266349.1 15672175 1113802 196222..196881 1 NC_002662.1 hypothetical protein 196881 ybjB 1113802 ybjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266349.1 196222 D 272623 CDS NP_266350.1 15672176 1113803 197074..197943 1 NC_002662.1 sugar-nucleotide biosynthesis and interconversions; glucose-1-phosphate thymidylyltransferase 197943 rmlA 1113803 rmlA Lactococcus lactis subsp. lactis Il1403 glucose-1-phosphate thymidylyltransferase NP_266350.1 197074 D 272623 CDS NP_266351.1 15672177 1113804 197991..198281 1 NC_002662.1 hypothetical protein 198281 ybjD 1113804 ybjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266351.1 197991 D 272623 CDS NP_266352.1 15672178 1113805 198350..198943 1 NC_002662.1 sugar-nucleotide biosynthesis and interconversions; dTDP-4-keto-6-deoxyglucose-3,5-epimerase 198943 cpsM 1113805 cpsM Lactococcus lactis subsp. lactis Il1403 dTDP-4-keto-6-deoxyglucose-3,5-epimerase NP_266352.1 198350 D 272623 CDS NP_266353.1 15672179 1113806 198943..199197 1 NC_002662.1 hypothetical protein 199197 ybjF 1113806 ybjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266353.1 198943 D 272623 CDS NP_266354.1 15672180 1113807 199239..200288 1 NC_002662.1 sugar-nucleotide biosynthesis and interconversions; dTDP-glucose 4,6-dehydratase 200288 rmlB 1113807 rmlB Lactococcus lactis subsp. lactis Il1403 dTDP-glucose 4,6-dehydratase NP_266354.1 199239 D 272623 CDS NP_266355.1 15672181 1113808 200377..201276 1 NC_002662.1 sugar-nucleotide biosynthesis and interconversions; dTDP-4-dehydrorhamnose reductase 201276 rmlC 1113808 rmlC Lactococcus lactis subsp. lactis Il1403 dTDP-4-dehydrorhamnose reductase NP_266355.1 200377 D 272623 CDS NP_266356.1 15672182 1113809 201410..202618 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; rhamnosyltransferase 202618 rgpA 1113809 rgpA Lactococcus lactis subsp. lactis Il1403 rhamnosyltransferase NP_266356.1 201410 D 272623 CDS NP_266357.1 15672183 1113810 202608..203567 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; rhamnosyltransferase 203567 rgpB 1113810 rgpB Lactococcus lactis subsp. lactis Il1403 rhamnosyltransferase NP_266357.1 202608 D 272623 CDS NP_266358.1 15672184 1113811 203548..204357 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; probably involved in side chain formation of rhamnose-glucose polysaccharide; polysaccharide ABC transporter permease 204357 rgpC 1113811 rgpC Lactococcus lactis subsp. lactis Il1403 polysaccharide ABC transporter permease NP_266358.1 203548 D 272623 CDS NP_266359.1 15672185 1113812 204357..205553 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; probably involved in side chain formation of rhamnose-glucose polysaccharide; polysaccharide ABC transporter ATP-binding protein 205553 rgpD 1113812 rgpD Lactococcus lactis subsp. lactis Il1403 polysaccharide ABC transporter ATP-binding protein NP_266359.1 204357 D 272623 CDS NP_266360.1 15672186 1113813 205546..205866 1 NC_002662.1 hypothetical protein 205866 ycaF 1113813 ycaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266360.1 205546 D 272623 CDS NP_266361.1 15672187 1113814 205908..206900 1 NC_002662.1 hypothetical protein 206900 ycaG 1113814 ycaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266361.1 205908 D 272623 CDS NP_266362.1 15672188 1113815 206916..207890 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; probably involved in side chain formation of rhamnose-glucose polysaccharide; glycosyltransferase 207890 rgpE 1113815 rgpE Lactococcus lactis subsp. lactis Il1403 glycosyltransferase NP_266362.1 206916 D 272623 CDS NP_266363.1 15672189 1113816 207900..209669 1 NC_002662.1 polysaccharide biosynthesis protein 209669 rgpF 1113816 rgpF Lactococcus lactis subsp. lactis Il1403 polysaccharide biosynthesis protein NP_266363.1 207900 D 272623 CDS NP_266364.1 15672190 1113817 209672..211216 1 NC_002662.1 hypothetical protein 211216 ycbA 1113817 ycbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266364.1 209672 D 272623 CDS NP_266365.1 15672191 1113818 211306..212031 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; glycosyltransferase 212031 ycbB 1113818 ycbB Lactococcus lactis subsp. lactis Il1403 glycosyltransferase NP_266365.1 211306 D 272623 CDS NP_266366.1 15672192 1113819 212028..212399 1 NC_002662.1 hypothetical protein 212399 ycbC 1113819 ycbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266366.1 212028 D 272623 CDS NP_266367.1 15672193 1113820 212383..213324 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; UDP-glucose 4-epimerase 213324 ycbD 1113820 ycbD Lactococcus lactis subsp. lactis Il1403 UDP-glucose 4-epimerase NP_266367.1 212383 D 272623 CDS NP_266368.1 15672194 1113821 213324..214751 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; polysaccharide biosynthesis export protein 214751 ycbK 1113821 ycbK Lactococcus lactis subsp. lactis Il1403 polysaccharide biosynthesis export protein NP_266368.1 213324 D 272623 CDS NP_266369.1 15672195 1113822 214748..215887 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; LPS biosynthesis protein 215887 ycbF 1113822 ycbF Lactococcus lactis subsp. lactis Il1403 LPS biosynthesis protein NP_266369.1 214748 D 272623 CDS NP_266370.1 15672196 1113823 215887..216723 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to Cps19aG protein in LPS gene claster of Streptococcus pneumoniae; LPS biosynthesis protein 216723 ycbG 1113823 ycbG Lactococcus lactis subsp. lactis Il1403 LPS biosynthesis protein NP_266370.1 215887 D 272623 CDS NP_266371.1 15672197 1113824 216713..217714 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to many glucosyl or galactosyl transferases involved in polysaccharide biosynthesis; sugar transferase 217714 ycbH 1113824 ycbH Lactococcus lactis subsp. lactis Il1403 sugar transferase NP_266371.1 216713 D 272623 CDS NP_266372.1 15672198 1113825 217716..218573 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to glycosyl transferases; sugar transferase 218573 ycbI 1113825 ycbI Lactococcus lactis subsp. lactis Il1403 sugar transferase NP_266372.1 217716 D 272623 CDS NP_266373.1 15672199 1113826 218600..219826 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to glycerol diester phosphodiesterases; LPS biosynthesis protein 219826 ycbJ 1113826 ycbJ Lactococcus lactis subsp. lactis Il1403 LPS biosynthesis protein NP_266373.1 218600 D 272623 CDS NP_266374.1 15672200 1113827 219837..220265 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; glycerol-3-phosphate cytidiltransferase 220265 tagD1 1113827 tagD1 Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphate cytidiltransferase NP_266374.1 219837 D 272623 CDS NP_266375.1 15672201 1113828 complement(220391..220903) 1 NC_002662.1 hypothetical protein 220903 yccB 1113828 yccB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266375.1 220391 R 272623 CDS NP_266376.1 15672202 1113829 221285..222766 1 NC_002662.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 222766 guaB 1113829 guaB Lactococcus lactis subsp. lactis Il1403 inosine 5'-monophosphate dehydrogenase NP_266376.1 221285 D 272623 CDS NP_266377.1 15672203 1113830 222972..224117 1 NC_002662.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 224117 yqeL 1113830 yqeL Lactococcus lactis subsp. lactis Il1403 GTP-binding protein YqeH NP_266377.1 222972 D 272623 CDS NP_266379.2 30023980 1113832 224764..226008 1 NC_002662.1 GTP-binding protein; counterpart of YnbA of Bacillus subtilis and HflX of Escherichia coli; hypothetical protein 226008 hflX 1113832 hflX Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266379.2 224764 D 272623 CDS NP_266380.2 30023981 1113833 226054..226368 1 NC_002662.1 hypothetical protein 226368 yccF 1113833 yccF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266380.2 226054 D 272623 CDS NP_266381.1 15672207 1113834 226415..227014 1 NC_002662.1 hypothetical protein 227014 yccG 1113834 yccG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266381.1 226415 D 272623 CDS NP_266382.1 15672208 1113835 227007..227597 1 NC_002662.1 hypothetical protein 227597 yccH 1113835 yccH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266382.1 227007 D 272623 CDS NP_266383.1 15672209 1113836 227643..228068 1 NC_002662.1 hypothetical protein 228068 yccI 1113836 yccI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266383.1 227643 D 272623 CDS NP_266384.1 15672210 1113837 228234..228593 1 NC_002662.1 hypothetical protein 228593 yccJ 1113837 yccJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266384.1 228234 D 272623 CDS NP_266385.1 15672211 1113838 228693..229427 1 NC_002662.1 hypothetical protein 229427 yccK 1113838 yccK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266385.1 228693 D 272623 CDS NP_266386.1 15672212 1113839 229477..230646 1 NC_002662.1 similar to YlbM protein of Bacillus subtilis; hypothetical protein 230646 yccL 1113839 yccL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266386.1 229477 D 272623 CDS NP_266387.1 15672213 1113840 230717..231142 1 NC_002662.1 similar to BacF protein from Enterococcus faecalis pheromone-responsive conjugative plasmid pPD1; hypothetical protein 231142 ycdA 1113840 ycdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266387.1 230717 D 272623 CDS NP_266388.1 15672214 1113841 231298..232014 1 NC_002662.1 similar to YeeN from E. coli; hypothetical protein 232014 ycdB 1113841 ycdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266388.1 231298 D 272623 CDS NP_266389.1 15672215 1113842 232081..232722 1 NC_002662.1 hypothetical protein 232722 ycdC 1113842 ycdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266389.1 232081 D 272623 CDS NP_266390.1 15672216 1113843 232719..233378 1 NC_002662.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 233378 ung 1113843 ung Lactococcus lactis subsp. lactis Il1403 uracil-DNA glycosylase NP_266390.1 232719 D 272623 CDS NP_266393.1 15672219 1113846 234472..235017 1 NC_002662.1 similar to tetR-family transcription regulators; transcriptional regulator 235017 ycdF 1113846 ycdF Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266393.1 234472 D 272623 CDS NP_266394.1 15672220 1113847 complement(235128..236588) 1 NC_002662.1 transport and binding protein; similar to several multidrug resistance proteins; transporter 236588 ycdH 1113847 ycdH Lactococcus lactis subsp. lactis Il1403 transporter NP_266394.1 235128 R 272623 CDS NP_266395.1 15672221 1113848 236778..237140 1 NC_002662.1 MerR family of transcription regulators; transcriptional regulator 237140 rmeC 1113848 rmeC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266395.1 236778 D 272623 CDS NP_266396.1 15672222 1113849 237226..237402 1 NC_002662.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 237402 rpsU 1113849 rpsU Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S21 NP_266396.1 237226 D 272623 CDS NP_266397.1 15672223 1113850 237609..240020 1 NC_002662.1 similar to YpiL and YigE; hypothetical protein 240020 ycdJ 1113850 ycdJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266397.1 237609 D 272623 CDS NP_266398.1 15672224 1113851 240032..240631 1 NC_002662.1 similar to Y39C12A.3 protein of Caenorhabditis elegans; similar to YceC, YihA and YpiF; hypothetical protein 240631 yceA 1113851 yceA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266398.1 240032 D 272623 CDS NP_266399.1 15672225 1113853 241256..241705 1 NC_002662.1 hypothetical protein 241705 yceD 1113853 yceD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266399.1 241256 D 272623 CDS NP_266400.1 15672226 1113854 241794..242606 1 NC_002662.1 hypothetical protein 242606 yceE 1113854 yceE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266400.1 241794 D 272623 CDS NP_266401.1 15672227 1113855 242796..243992 1 NC_002662.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 243992 pgk 1113855 pgk Lactococcus lactis subsp. lactis Il1403 phosphoglycerate kinase NP_266401.1 242796 D 272623 CDS NP_266402.2 30023982 1113856 244069..245055 1 NC_002662.1 similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone; DhaKLM operon coactivator DhaQ 245055 dhaK 1113856 dhaK Lactococcus lactis subsp. lactis Il1403 DhaKLM operon coactivator DhaQ NP_266402.2 244069 D 272623 CDS NP_266403.2 30023983 1113857 complement(245056..245598) 1 NC_002662.1 helix-turn-helix from TetR family; similar to Y07639; hypothetical protein 245598 yceG 1113857 yceG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266403.2 245056 R 272623 CDS NP_266404.2 30023984 1113858 245692..246690 1 NC_002662.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 246690 dhaL 1113858 dhaL Lactococcus lactis subsp. lactis Il1403 dihydroxyacetone kinase subunit DhaK NP_266404.2 245692 D 272623 CDS NP_266405.1 15672231 1113859 246700..247278 1 NC_002662.1 anaerobic energy metabolism; similar to the C-terminal part of dihydroxyacetone kinase from Citrobacter freundii; dihydroxyacetone kinase 247278 dhaM 1113859 dhaM Lactococcus lactis subsp. lactis Il1403 dihydroxyacetone kinase NP_266405.1 246700 D 272623 CDS NP_266406.1 15672232 1113860 247275..247646 1 NC_002662.1 hypothetical protein 247646 yceJ 1113860 yceJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266406.1 247275 D 272623 CDS NP_266407.1 15672233 1113861 247656..248372 1 NC_002662.1 transport and binding protein; carbohydrates, organic alcohols and acids; glycerol uptake facilitator 248372 glpF1 1113861 glpF1 Lactococcus lactis subsp. lactis Il1403 glycerol uptake facilitator NP_266407.1 247656 D 272623 CDS NP_266408.1 15672234 1113862 complement(248411..249790) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; similar to dipeptidase PepD of Lactobacillus helveticus; dipeptidase 249790 pepDA 1113862 pepDA Lactococcus lactis subsp. lactis Il1403 dipeptidase NP_266408.1 248411 R 272623 CDS NP_266409.1 15672235 1113863 249968..250615 1 NC_002662.1 TetR/AcrR family of transcription regulators; transcriptional regulator 250615 ycfA 1113863 ycfA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266409.1 249968 D 272623 CDS NP_266410.1 15672236 1113864 250701..251447 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 251447 ycfB 1113864 ycfB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266410.1 250701 D 272623 CDS NP_266411.1 15672237 1113865 251444..252586 1 NC_002662.1 transport and binding protein; ABC transporter permease 252586 ycfC 1113865 ycfC Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266411.1 251444 D 272623 CDS NP_266412.1 15672238 1113866 252684..253853 1 NC_002662.1 UPF0064 family; similar to YwbD of Bacillus subtilis; hypothetical protein 253853 ycfD 1113866 ycfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266412.1 252684 D 272623 CDS NP_266413.1 15672239 1113867 254043..255965 1 NC_002662.1 gluconeogenesis; similar to fructose-1,6-bisphosphatase of Bacillus subtilis; fructose-1,6-bisphosphatase 255965 fbp 1113867 fbp Lactococcus lactis subsp. lactis Il1403 fructose-1,6-bisphosphatase NP_266413.1 254043 D 272623 CDS NP_266414.1 15672240 1113868 complement(256200..257471) 1 NC_002662.1 similar to YtfP of Bacillus subtilis; hypothetical protein 257471 ycfF 1113868 ycfF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266414.1 256200 R 272623 CDS NP_266415.1 15672241 1113869 257612..258439 1 NC_002662.1 UPF0031 family; hypothetical protein 258439 ycfG 1113869 ycfG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266415.1 257612 D 272623 CDS NP_266416.1 15672242 1113870 258588..259001 1 NC_002662.1 hypothetical protein 259001 ycfH 1113870 ycfH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266416.1 258588 D 272623 CDS NP_266417.1 15672243 1113871 259172..261007 1 NC_002662.1 transport and binding protein; contains two ATP binding domains; ABC transporter ATP-binding protein 261007 ycfI 1113871 ycfI Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266417.1 259172 D 272623 CDS NP_266420.1 15672246 1113874 262977..263630 1 NC_002662.1 hypothetical protein 263630 ycgC 1113874 ycgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266420.1 262977 D 272623 CDS NP_266421.2 30023985 1113875 complement(263676..264695) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 264695 ycgD 1113875 ycgD Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266421.2 263676 R 272623 CDS NP_266422.1 15672248 1113876 complement(265021..265497) 1 NC_002662.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 265497 ycgE 1113876 ycgE Lactococcus lactis subsp. lactis Il1403 S-ribosylhomocysteinase NP_266422.1 265021 R 272623 CDS NP_266423.1 15672249 1113877 265711..266175 1 NC_002662.1 hypothetical protein 266175 ycgF 1113877 ycgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266423.1 265711 D 272623 CDS NP_266424.1 15672250 1113878 266240..267085 1 NC_002662.1 aerobic energy metabolism; aldo/keto reductase family; oxidoreductase 267085 ycgG 1113878 ycgG Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266424.1 266240 D 272623 CDS NP_266425.1 15672251 1113879 267248..267763 1 NC_002662.1 similar to nicotinamidase or pyrazinamidase from Mycobacterium smegmatis; amidase 267763 ycgH 1113879 ycgH Lactococcus lactis subsp. lactis Il1403 amidase NP_266425.1 267248 D 272623 CDS NP_266426.1 15672252 1113880 267882..268430 1 NC_002662.1 hypothetical protein 268430 ycgI 1113880 ycgI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266426.1 267882 D 272623 CDS NP_266427.1 15672253 1113881 268427..268711 1 NC_002662.1 hypothetical protein 268711 ycgJ 1113881 ycgJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266427.1 268427 D 272623 CDS NP_266428.1 15672254 1113882 complement(268750..270069) 1 NC_002662.1 cell wall hydrolase; muramidase-2 like protein in Enterococcus faecalis; in Enterococcus faecalis a mutant in this gene has no effect on virulence in mouse models; Listeria monocytogenes MurA in involved in general autolysis; contains an N-terminal muramid; autolysin 270069 acmA 1113882 acmA Lactococcus lactis subsp. lactis Il1403 autolysin NP_266428.1 268750 R 272623 CDS NP_266429.1 15672255 1113883 270413..272656 1 NC_002662.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 272656 nrdD 1113883 nrdD Lactococcus lactis subsp. lactis Il1403 anaerobic ribonucleoside triphosphate reductase NP_266429.1 270413 D 272623 CDS NP_266430.1 15672256 1113884 272670..273269 1 NC_002662.1 salvage of nucleosides and nucleotides; anaerobic ribonucleoside-triphosphate reductase activating protein 273269 nrdG 1113884 nrdG Lactococcus lactis subsp. lactis Il1403 anaerobic ribonucleoside-triphosphate reductase activating protein NP_266430.1 272670 D 272623 CDS NP_266431.1 15672257 1113885 complement(273378..273884) 1 NC_002662.1 hypothetical protein 273884 ychC 1113885 ychC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266431.1 273378 R 272623 CDS NP_266432.1 15672258 1113886 274176..275444 1 NC_002662.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 275444 eno 1113886 eno Lactococcus lactis subsp. lactis Il1403 phosphopyruvate hydratase NP_266432.1 274176 D 272623 CDS NP_266433.1 15672259 1113887 275743..276576 1 NC_002662.1 with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 276576 cbiO 1113887 cbiO Lactococcus lactis subsp. lactis Il1403 cobalt transporter ATP-binding subunit NP_266433.1 275743 D 272623 CDS NP_266434.1 15672260 1113888 276762..277628 1 NC_002662.1 with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 277628 cbiO 1113888 cbiO Lactococcus lactis subsp. lactis Il1403 cobalt transporter ATP-binding subunit NP_266434.1 276762 D 272623 CDS NP_266435.1 15672261 1113889 277628..278428 1 NC_002662.1 transport and binding protein; ABC transporter permease 278428 ychF 1113889 ychF Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266435.1 277628 D 272623 CDS NP_266436.1 15672262 1113890 278452..279063 1 NC_002662.1 similar to bacterocin transport accessory protein Bta of Streptococcus pneumoniae; maybe a part of trasport system ychDEF; hypothetical protein 279063 ychG 1113890 ychG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266436.1 278452 D 272623 CDS NP_266437.1 15672263 1113891 279273..280043 1 NC_002662.1 similar to acetyltransferases; acetyltransferase 280043 ychH 1113891 ychH Lactococcus lactis subsp. lactis Il1403 acetyltransferase NP_266437.1 279273 D 272623 CDS NP_266438.1 15672264 1113892 280180..281334 1 NC_002662.1 energy metabolism, amino acids and amines; similar to several hippurate hydrolases and amino acid amidohydrolases; may be a peptidase.; amino acid amidohydrolase 281334 yciA 1113892 yciA Lactococcus lactis subsp. lactis Il1403 amino acid amidohydrolase NP_266438.1 280180 D 272623 CDS NP_266439.1 15672265 1113893 281456..282574 1 NC_002662.1 endo-1,4-beta-xylanase D 282574 xynD 1113893 xynD Lactococcus lactis subsp. lactis Il1403 endo-1,4-beta-xylanase D NP_266439.1 281456 D 272623 CDS NP_266440.1 15672266 1113894 283758..284369 1 NC_002662.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 284369 rpsD 1113894 rpsD Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S4 NP_266440.1 283758 D 272623 CDS NP_266441.1 15672267 1113895 284496..286634 1 NC_002662.1 similar to ydcI of Bacillus subtilis; contains has S1 motif; similar to tex (toxin expression regulator) genes; hypothetical protein 286634 yciC 1113895 yciC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266441.1 284496 D 272623 CDS NP_266442.1 15672268 1113896 286731..287174 1 NC_002662.1 similar to adenylate kinase; hypothetical protein 287174 yciD 1113896 yciD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266442.1 286731 D 272623 CDS NP_266443.1 15672269 1113897 287447..288505 1 NC_002662.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 288505 add 1113897 add Lactococcus lactis subsp. lactis Il1403 adenosine deaminase NP_266443.1 287447 D 272623 CDS NP_266444.1 15672270 1113898 complement(288537..288755) 1 NC_002662.1 hypothetical protein 288755 yciF 1113898 yciF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266444.1 288537 R 272623 CDS NP_266445.1 15672271 1113899 complement(288792..289205) 1 NC_002662.1 hypothetical protein 289205 yciG 1113899 yciG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266445.1 288792 R 272623 CDS NP_266446.1 15672272 1113900 complement(289409..291091) 1 NC_002662.1 hypothetical protein 291091 yciH 1113900 yciH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266446.1 289409 R 272623 CDS NP_266447.1 15672273 1113901 complement(291264..291494) 1 NC_002662.1 similar to ykzG Bacillus subtilis; hypothetical protein 291494 ycjA 1113901 ycjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266447.1 291264 R 272623 CDS NP_266448.1 15672274 1113902 291804..292529 1 NC_002662.1 hypothetical protein 292529 ycjB 1113902 ycjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266448.1 291804 D 272623 CDS NP_266449.1 15672275 1113903 292483..293052 1 NC_002662.1 ribosomal proteins; synthesis and modification; similar to several ribosomal-protein-alanine N-acetyltransferases; acetyltransferase 293052 ycjC 1113903 ycjC Lactococcus lactis subsp. lactis Il1403 acetyltransferase NP_266449.1 292483 D 272623 CDS NP_266450.1 15672276 1113904 293057..293527 1 NC_002662.1 ribosomal proteins; synthesis and modification; similar to different ribosomal-protein-alanine acetyltransferases; acetyltransferase 293527 ycjD 1113904 ycjD Lactococcus lactis subsp. lactis Il1403 acetyltransferase NP_266450.1 293057 D 272623 CDS NP_266451.1 15672277 1113905 293530..294570 1 NC_002662.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 294570 gcp 1113905 gcp Lactococcus lactis subsp. lactis Il1403 DNA-binding/iron metalloprotein/AP endonuclease NP_266451.1 293530 D 272623 CDS NP_266452.1 15672278 1113906 294570..294770 1 NC_002662.1 hypothetical protein 294770 ycjF 1113906 ycjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266452.1 294570 D 272623 CDS NP_266453.1 15672279 1113907 complement(294964..295101) 1 NC_002662.1 hypothetical protein 295101 ycjG 1113907 ycjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266453.1 294964 R 272623 CDS NP_266454.1 15672280 1113908 complement(295201..295989) 1 NC_002662.1 hypothetical protein 295989 ycjH 1113908 ycjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266454.1 295201 R 272623 CDS NP_266455.1 15672281 1113909 296289..297338 1 NC_002662.1 hypothetical protein 297338 ycjI 1113909 ycjI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266455.1 296289 D 272623 CDS NP_266456.1 15672282 1113910 297457..298197 1 NC_002662.1 transport and binding protein, anions; phosphonate ABC transporter ATP-binding protein 298197 phnC 1113910 phnC Lactococcus lactis subsp. lactis Il1403 phosphonate ABC transporter ATP-binding protein NP_266456.1 297457 D 272623 CDS NP_266457.1 15672283 1113911 298198..299010 1 NC_002662.1 transport and binding protein, anions; phosphonate ABC transporter permease 299010 phnB 1113911 phnB Lactococcus lactis subsp. lactis Il1403 phosphonate ABC transporter permease NP_266457.1 298198 D 272623 CDS NP_266458.1 15672284 1113912 299025..299834 1 NC_002662.1 transport and binding protein, anions; phosphonate ABC transporter permease 299834 phnE 1113912 phnE Lactococcus lactis subsp. lactis Il1403 phosphonate ABC transporter permease NP_266458.1 299025 D 272623 CDS NP_266459.1 15672285 1113913 299840..301399 1 NC_002662.1 nucleotide and nucleoside interconversions; similar to nucleotide phosphodiesterases and UDP-sugar hydrolases; phosphatase 301399 ycjM 1113913 ycjM Lactococcus lactis subsp. lactis Il1403 phosphatase NP_266459.1 299840 D 272623 CDS NP_266460.1 15672286 1113914 301726..302208 1 NC_002662.1 adaptations and atypical conditions; antioxidant activity; may remove peroidases or hydrogen peroxide; TPX/TAGD family; thiol peroxidase 302208 tpx 1113914 tpx Lactococcus lactis subsp. lactis Il1403 thiol peroxidase NP_266460.1 301726 D 272623 CDS NP_266461.1 15672287 1113915 302381..304921 1 NC_002662.1 evidence experimental PMID:1352755; degradation of proteins, peptides, and glycopeptides; aminopeptidase N 304921 pepN 1113915 pepN Lactococcus lactis subsp. lactis Il1403 aminopeptidase N NP_266461.1 302381 D 272623 CDS NP_266462.1 15672288 1113916 complement(304960..306153) 1 NC_002662.1 multidrug resistance; similar to NapC protein from Enterococcus hirae; similar to many tetracycline resistance efflux proteins of class H; multidrug-efflux transporter 306153 napC 1113916 napC Lactococcus lactis subsp. lactis Il1403 multidrug-efflux transporter NP_266462.1 304960 R 272623 CDS NP_266463.1 15672289 1113917 complement(306480..306959) 1 NC_002662.1 similar to NapB protein of Enterococcus hirae; MarR family transcriptional regulator 306959 napB 1113917 napB Lactococcus lactis subsp. lactis Il1403 MarR family transcriptional regulator NP_266463.1 306480 R 272623 CDS NP_266464.1 15672290 1113918 complement(306956..308233) 1 NC_002662.1 transort and binding protein, cations; similar to several cation efflux system proteins; cation transporter 308233 ydaE 1113918 ydaE Lactococcus lactis subsp. lactis Il1403 cation transporter NP_266464.1 306956 R 272623 CDS NP_266465.1 15672291 1113919 308509..308859 1 NC_002662.1 hypothetical protein 308859 ydaF 1113919 ydaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266465.1 308509 D 272623 CDS NP_266466.1 15672292 1113920 309171..310892 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 310892 ydaG 1113920 ydaG Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_266466.1 309171 D 272623 CDS NP_266467.1 15672293 1113921 310896..312890 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 312890 ydbA 1113921 ydbA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_266467.1 310896 D 272623 CDS NP_266468.1 15672294 1113922 313067..314332 1 NC_002662.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 314332 murA1 1113922 murA1 Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_266468.1 313067 D 272623 CDS NP_266469.1 15672295 1113923 314378..314596 1 NC_002662.1 hypothetical protein 314596 ydbC 1113923 ydbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266469.1 314378 D 272623 CDS NP_266470.2 30023986 1113924 complement(314623..314961) 1 NC_002662.1 hypothetical protein 314961 ydbD 1113924 ydbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266470.2 314623 R 272623 CDS NP_266471.1 15672297 1113925 complement(315003..315551) 1 NC_002662.1 similar to BioY protein precursor of Bacillus sphaericus; hypothetical protein 315551 ydbE 1113925 ydbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266471.1 315003 R 272623 CDS NP_266472.1 15672298 1113926 complement(315662..316138) 1 NC_002662.1 regulatory funcion; similar to EbsC regulator of Enterococcus faecalis; transcriptional regulator 316138 ydbF 1113926 ydbF Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266472.1 315662 R 272623 CDS NP_266473.1 15672299 1113927 complement(316202..316777) 1 NC_002662.1 hypothetical protein 316777 ydbH 1113927 ydbH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266473.1 316202 R 272623 CDS NP_266474.1 15672300 1113928 317479..318339 1 NC_002662.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins; outer membrane lipoprotein 318339 plpA 1113928 plpA Lactococcus lactis subsp. lactis Il1403 outer membrane lipoprotein NP_266474.1 317479 D 272623 CDS NP_266475.1 15672301 1113929 318483..319343 1 NC_002662.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins; outer membrane lipoprotein 319343 plpB 1113929 plpB Lactococcus lactis subsp. lactis Il1403 outer membrane lipoprotein NP_266475.1 318483 D 272623 CDS NP_266476.1 15672302 1113930 319460..320320 1 NC_002662.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins; outer membrane lipoprotein 320320 plpC 1113930 plpC Lactococcus lactis subsp. lactis Il1403 outer membrane lipoprotein NP_266476.1 319460 D 272623 CDS NP_266477.1 15672303 1113931 320339..321199 1 NC_002662.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins; outer membrane lipoprotein 321199 plpD 1113931 plpD Lactococcus lactis subsp. lactis Il1403 outer membrane lipoprotein NP_266477.1 320339 D 272623 CDS NP_266478.1 15672304 1113932 321303..322409 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter ATP binding protein 322409 ydcB 1113932 ydcB Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter ATP binding protein NP_266478.1 321303 D 272623 CDS NP_266479.1 15672305 1113933 322409..323104 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter permease 323104 ydcC 1113933 ydcC Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter permease NP_266479.1 322409 D 272623 CDS NP_266480.1 15672306 1113934 323152..323700 1 NC_002662.1 hypothetical protein 323700 ydcD 1113934 ydcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266480.1 323152 D 272623 CDS NP_266481.1 15672307 1113935 323809..325506 1 NC_002662.1 transport and binding protein; contains two ATP-binding domains; ABC transporter ATP-binding protein 325506 ydcE 1113935 ydcE Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266481.1 323809 D 272623 CDS NP_266482.1 15672308 1113936 325499..326320 1 NC_002662.1 transport and binding protein; ABC transporter permease 326320 ydcF 1113936 ydcF Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266482.1 325499 D 272623 CDS NP_266483.1 15672309 1113937 326483..326776 1 NC_002662.1 PBSX(XRE) family of transcription regulators; transcriptional regulator 326776 ydcG 1113937 ydcG Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266483.1 326483 D 272623 CDS NP_266484.1 15672310 1113939 327472..328422 1 NC_002662.1 transort and binding protein, cations; ferrichrome ABC transporter permease 328422 fhuB 1113939 fhuB Lactococcus lactis subsp. lactis Il1403 ferrichrome ABC transporter permease NP_266484.1 327472 D 272623 CDS NP_266485.1 15672311 1113940 328424..329362 1 NC_002662.1 transort and binding protein, cations; ferrichrome ABC transporter permease 329362 fhuG 1113940 fhuG Lactococcus lactis subsp. lactis Il1403 ferrichrome ABC transporter permease NP_266485.1 328424 D 272623 CDS NP_266486.1 15672312 1113941 329447..330388 1 NC_002662.1 ferrichrome ABC transporter substrate binding protein 330388 fhuD 1113941 fhuD Lactococcus lactis subsp. lactis Il1403 ferrichrome ABC transporter substrate binding protein NP_266486.1 329447 D 272623 CDS NP_266487.1 15672313 1113942 330450..331355 1 NC_002662.1 LysR-family regulators; probably cotranscribed with other fhu genes; fhu operon transcription regulator 331355 fhuR 1113942 fhuR Lactococcus lactis subsp. lactis Il1403 fhu operon transcription regulator NP_266487.1 330450 D 272623 CDS NP_266488.1 15672314 1113943 complement(331413..332594) 1 NC_002662.1 transport and binding protein; transporter 332594 yddA 1113943 yddA Lactococcus lactis subsp. lactis Il1403 transporter NP_266488.1 331413 R 272623 CDS NP_266489.1 15672315 1113944 complement(332607..333425) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 333425 yddB 1113944 yddB Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266489.1 332607 R 272623 CDS NP_266490.1 15672316 1113945 333567..333914 1 NC_002662.1 hypothetical protein 333914 yddC 1113945 yddC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266490.1 333567 D 272623 CDS NP_266491.1 15672317 1113946 333940..334332 1 NC_002662.1 hypothetical protein 334332 yddD 1113946 yddD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266491.1 333940 D 272623 CDS NP_266492.1 15672318 1113947 334509..335210 1 NC_002662.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 335210 gpmA 1113947 gpmA Lactococcus lactis subsp. lactis Il1403 phosphoglyceromutase NP_266492.1 334509 D 272623 CDS NP_266493.1 15672319 1113948 335384..335947 1 NC_002662.1 cellular processes, detoxification; directly reduces organic hydroperoxides; Probably induced by heat shock, salt stress, oxidative stress and glucose limitation; general stress protein; alkyl hydroperoxide reductase 335947 ahpC 1113948 ahpC Lactococcus lactis subsp. lactis Il1403 alkyl hydroperoxide reductase NP_266493.1 335384 D 272623 CDS NP_266494.1 15672320 1113949 336014..337543 1 NC_002662.1 cellular processes, detoxification; protects the cell against DNA damage by alkyl hydroperoxides; similar to NADH peroxidase nox-1 of Streptococcus mutans; alkyl hydroperoxide reductase 337543 ahpF 1113949 ahpF Lactococcus lactis subsp. lactis Il1403 alkyl hydroperoxide reductase NP_266494.1 336014 D 272623 CDS NP_266495.1 15672321 1113950 337709..339874 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; penicillin-binding protein 2B 339874 pbp2B 1113950 pbp2B Lactococcus lactis subsp. lactis Il1403 penicillin-binding protein 2B NP_266495.1 337709 D 272623 CDS NP_266496.1 15672322 1113951 340013..340609 1 NC_002662.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 340609 recR 1113951 recR Lactococcus lactis subsp. lactis Il1403 recombination protein RecR NP_266496.1 340013 D 272623 CDS NP_266497.1 15672323 1113952 340726..341775 1 NC_002662.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 341775 ddl 1113952 ddl Lactococcus lactis subsp. lactis Il1403 D-alanyl-alanine synthetase A NP_266497.1 340726 D 272623 CDS NP_266498.1 15672324 1113953 341850..343172 1 NC_002662.1 cell envelope murein sacculus and peptidoglycan; MURCDEF family; D-Ala-D-Ala adding enzyme 343172 murF 1113953 murF Lactococcus lactis subsp. lactis Il1403 D-Ala-D-Ala adding enzyme NP_266498.1 341850 D 272623 CDS NP_266499.1 15672325 1113954 343342..344994 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter substrate binding protein 344994 optS 1113954 optS Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter substrate binding protein NP_266499.1 343342 D 272623 CDS NP_266500.1 15672326 1113955 345303..346940 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter substrate binding protein 346940 optA 1113955 optA Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter substrate binding protein NP_266500.1 345303 D 272623 CDS NP_266501.1 15672327 1113956 347018..347929 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter permease 347929 optB 1113956 optB Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter permease NP_266501.1 347018 D 272623 CDS NP_266502.1 15672328 1113957 347945..348976 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter permease 348976 optC 1113957 optC Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter permease NP_266502.1 347945 D 272623 CDS NP_266503.1 15672329 1113958 348979..350028 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter ATP binding protein 350028 optD 1113958 optD Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter ATP binding protein NP_266503.1 348979 D 272623 CDS NP_266504.1 15672330 1113959 350025..350966 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter ATP binding protein 350966 optF 1113959 optF Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter ATP binding protein NP_266504.1 350025 D 272623 CDS NP_266505.1 15672331 1113960 351198..352769 1 NC_002662.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 352769 prfC 1113960 prfC Lactococcus lactis subsp. lactis Il1403 peptide chain release factor 3 NP_266505.1 351198 D 272623 CDS NP_266506.1 15672332 1113961 353033..354676 1 NC_002662.1 RNA processing; ATP-dependent RNA-binding protein with helicase activity; similar to DEAD box family helicases; ATP-dependent RNA helicase 354676 rheA 1113961 rheA Lactococcus lactis subsp. lactis Il1403 ATP-dependent RNA helicase NP_266506.1 353033 D 272623 CDS NP_266507.1 15672333 1113962 355047..355958 1 NC_002662.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 355958 era 1113962 era Lactococcus lactis subsp. lactis Il1403 GTP-binding protein Era NP_266507.1 355047 D 272623 CDS NP_266508.1 15672334 1113963 356055..357647 1 NC_002662.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 357647 asnB 1113963 asnB Lactococcus lactis subsp. lactis Il1403 asparagine synthetase B NP_266508.1 356055 D 272623 CDS NP_266509.1 15672335 1113964 357841..358659 1 NC_002662.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 358659 mutM 1113964 mutM Lactococcus lactis subsp. lactis Il1403 formamidopyrimidine-DNA glycosylase NP_266509.1 357841 D 272623 CDS NP_266510.1 15672336 1113965 358813..359976 1 NC_002662.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 359976 recA 1113965 recA Lactococcus lactis subsp. lactis Il1403 recombinase A NP_266510.1 358813 D 272623 CDS NP_266511.1 15672337 1113966 complement(359989..361362) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 361362 ydgB 1113966 ydgB Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_266511.1 359989 R 272623 CDS NP_266512.1 15672338 1113967 complement(361431..362810) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 362810 ydgC 1113967 ydgC Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_266512.1 361431 R 272623 CDS NP_266513.1 15672339 1113968 362957..363337 1 NC_002662.1 similar to YlbF protein of Bacillus subtilis; involved in competence and sporulation development; hypothetical protein 363337 ydgD 1113968 ydgD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266513.1 362957 D 272623 CDS NP_266514.1 15672340 1113969 363312..363638 1 NC_002662.1 similar to hypothetical YlbG protein of Bacillus subtilis; hypothetical protein 363638 ydgE 1113969 ydgE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266514.1 363312 D 272623 CDS NP_266515.1 15672341 1113970 363868..364386 1 NC_002662.1 hypothetical protein 364386 ydgG 1113970 ydgG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266515.1 363868 D 272623 CDS NP_266516.1 15672342 1113971 complement(364451..365044) 1 NC_002662.1 similar to hypothetical YjbK protein Bacillus subtilis; hypothetical protein 365044 ydgF 1113971 ydgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266516.1 364451 R 272623 CDS NP_266517.1 15672343 1113972 365261..365905 1 NC_002662.1 similar to YoaT protein of Bacillus subtilis; hypothetical protein 365905 ydgH 1113972 ydgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266517.1 365261 D 272623 CDS NP_266518.2 30023987 1113973 366093..366752 1 NC_002662.1 similar to YjbM protein of Bacillus subtilis; GTP pyrophosphokinase 366752 ydgI 1113973 ydgI Lactococcus lactis subsp. lactis Il1403 GTP pyrophosphokinase NP_266518.2 366093 D 272623 CDS NP_266519.1 15672345 1113974 366739..367551 1 NC_002662.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 367551 ppnK 1113974 ppnK Lactococcus lactis subsp. lactis Il1403 inorganic polyphosphate/ATP-NAD kinase NP_266519.1 366739 D 272623 CDS NP_266520.1 15672346 1113975 367551..368432 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; family 2 of pseudouridine synthases; pseudouridine synthase 368432 rluE 1113975 rluE Lactococcus lactis subsp. lactis Il1403 pseudouridine synthase NP_266520.1 367551 D 272623 CDS NP_266521.1 15672347 1113976 complement(368474..369304) 1 NC_002662.1 translation; protein modification; peptidyl-prolyl cis-trans isomerase 369304 ppiA 1113976 ppiA Lactococcus lactis subsp. lactis Il1403 peptidyl-prolyl cis-trans isomerase NP_266521.1 368474 R 272623 CDS NP_266522.1 15672348 1113977 369615..371048 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; there is another lysine specific permease LysP; lysine specific permease 371048 lysQ 1113977 lysQ Lactococcus lactis subsp. lactis Il1403 lysine specific permease NP_266522.1 369615 D 272623 CDS NP_266523.1 15672349 1113978 371163..371975 1 NC_002662.1 hypothetical protein 371975 ydhB 1113978 ydhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266523.1 371163 D 272623 CDS NP_266524.1 15672350 1113979 371975..372952 1 NC_002662.1 similar to hypothetical protein TP0796 Treponema pallidum; hypothetical protein 372952 ydhC 1113979 ydhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266524.1 371975 D 272623 CDS NP_266525.1 15672351 1113980 373134..373424 1 NC_002662.1 transposon related function; hypothetical protein 373424 ydhD 1113980 ydhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266525.1 373134 D 272623 CDS NP_266526.1 15672352 1113981 373520..374281 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904D 374281 tra904D 1113981 tra904D Lactococcus lactis subsp. lactis Il1403 transposase of IS904D NP_266526.1 373520 D 272623 CDS NP_266527.1 15672353 1113982 374338..374895 1 NC_002662.1 transposon related function; hypothetical protein 374895 ydhE 1113982 ydhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266527.1 374338 D 272623 CDS NP_266528.1 15672354 1113983 374892..375710 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; IS1077C transposase 375710 tra1077C 1113983 tra1077C Lactococcus lactis subsp. lactis Il1403 IS1077C transposase NP_266528.1 374892 D 272623 CDS NP_266529.1 15672355 1113984 complement(375784..377268) 1 NC_002662.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 377268 lysS 1113984 lysS Lactococcus lactis subsp. lactis Il1403 lysyl-tRNA synthetase NP_266529.1 375784 R 272623 CDS NP_266530.1 15672356 1113985 complement(377467..378285) 1 NC_002662.1 LysR-family regulators; LysR family transcriptional regulator 378285 rlrG 1113985 rlrG Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_266530.1 377467 R 272623 CDS NP_266531.1 15672357 1113986 378449..379444 1 NC_002662.1 hypothetical protein 379444 ydhF 1113986 ydhF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266531.1 378449 D 272623 CDS NP_266532.1 15672358 1113987 complement(379657..380601) 1 NC_002662.1 glycolysis; similar to malate dehydrogenase; L-lactate dehydrogenase 380601 ldhB 1113987 ldhB Lactococcus lactis subsp. lactis Il1403 L-lactate dehydrogenase NP_266532.1 379657 R 272623 CDS NP_266533.1 15672359 1113988 complement(380895..381716) 1 NC_002662.1 LysR-family regulators; LysR family transcriptional regulator 381716 rlrD 1113988 rlrD Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_266533.1 380895 R 272623 CDS NP_266534.1 15672360 1113989 381871..382845 1 NC_002662.1 similar to exfoliative toxin A; transport and binding protein; tellurite resistance protein or related permease; permease 382845 ydiA 1113989 ydiA Lactococcus lactis subsp. lactis Il1403 permease NP_266534.1 381871 D 272623 CDS NP_266535.1 15672361 1113990 383134..384354 1 NC_002662.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 384354 ydiB 1113990 ydiB Lactococcus lactis subsp. lactis Il1403 thiamine biosynthesis protein ThiI NP_266535.1 383134 D 272623 CDS NP_266536.1 15672362 1113991 384568..385971 1 NC_002662.1 transport and binding protein; multidrug resistance; efflux pump antibiotic resistance protein 385971 ydiC 1113991 ydiC Lactococcus lactis subsp. lactis Il1403 efflux pump antibiotic resistance protein NP_266536.1 384568 D 272623 CDS NP_266537.1 15672363 1113992 386132..386737 1 NC_002662.1 fatty acid and phospholipid metabolism; ACP phosphodiesterase 386737 ydiD 1113992 ydiD Lactococcus lactis subsp. lactis Il1403 ACP phosphodiesterase NP_266537.1 386132 D 272623 CDS NP_266538.1 15672364 1113993 386834..387268 1 NC_002662.1 hypothetical protein 387268 ydiE 1113993 ydiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266538.1 386834 D 272623 CDS NP_266539.1 15672365 1113994 complement(387304..389346) 1 NC_002662.1 transort and binding protein, cations; Na+/H+ antiporter 389346 ydiF 1113994 ydiF Lactococcus lactis subsp. lactis Il1403 Na+/H+ antiporter NP_266539.1 387304 R 272623 CDS NP_266540.1 15672366 1113995 complement(389437..389907) 1 NC_002662.1 hypothetical protein 389907 ydiG 1113995 ydiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266540.1 389437 R 272623 CDS NP_266541.1 15672367 1113996 complement(390031..391290) 1 NC_002662.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 391290 tyrS 1113996 tyrS Lactococcus lactis subsp. lactis Il1403 tyrosyl-tRNA synthetase NP_266541.1 390031 R 272623 CDS NP_266542.1 15672368 1113997 391435..393840 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; penicillin-binding protein 1B 393840 pbp1B 1113997 pbp1B Lactococcus lactis subsp. lactis Il1403 penicillin-binding protein 1B NP_266542.1 391435 D 272623 CDS NP_266543.1 15672369 1113998 complement(393898..394965) 1 NC_002662.1 evidence experimental PMID:8535515; degradation of proteins, peptides, and glycopeptides; glutamyl aminopeptidase 394965 pepA 1113998 pepA Lactococcus lactis subsp. lactis Il1403 glutamyl aminopeptidase NP_266543.1 393898 R 272623 CDS NP_266544.1 15672370 1113999 395161..395352 1 NC_002662.1 hypothetical protein 395352 ydjB 1113999 ydjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266544.1 395161 D 272623 CDS NP_266545.1 15672371 1114000 395394..395711 1 NC_002662.1 thioredoxin, glutaredoxin, and glutathione; similar to the thioredoxin H-type from plants; thioredoxin H-type 395711 trxH 1114000 trxH Lactococcus lactis subsp. lactis Il1403 thioredoxin H-type NP_266545.1 395394 D 272623 CDS NP_266546.1 15672372 1114001 395797..396423 1 NC_002662.1 similar to YtpR of Bacillus subtilis and phenylalanine tRNA ligase; hypothetical protein 396423 ydjD 1114001 ydjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266546.1 395797 D 272623 CDS NP_266547.1 15672373 1114002 396586..397926 1 NC_002662.1 aerobic energy metabolism; NADH oxidase 397926 noxE 1114002 noxE Lactococcus lactis subsp. lactis Il1403 NADH oxidase NP_266547.1 396586 D 272623 CDS NP_266548.1 15672374 1114003 398016..398405 1 NC_002662.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 398405 ssbA 1114003 ssbA Lactococcus lactis subsp. lactis Il1403 single-stranded DNA-binding protein NP_266548.1 398016 D 272623 CDS NP_266549.1 15672375 1114004 398525..398809 1 NC_002662.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 398809 groES 1114004 groES Lactococcus lactis subsp. lactis Il1403 co-chaperonin GroES NP_266549.1 398525 D 272623 CDS NP_266550.1 15672376 1114005 398897..400525 1 NC_002662.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 400525 groEL 1114005 groEL Lactococcus lactis subsp. lactis Il1403 chaperonin GroEL NP_266550.1 398897 D 272623 CDS NP_266551.1 15672377 1114006 complement(400571..401383) 1 NC_002662.1 similar to yycJ Bacillus subtilis; hypothetical protein 401383 yeaA 1114006 yeaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266551.1 400571 R 272623 CDS NP_266552.1 15672378 1114007 complement(401554..402996) 1 NC_002662.1 evidence experimental PMID:9172368; two-component systems; sensor protein kinase 402996 kinC 1114007 kinC Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_266552.1 401554 R 272623 CDS NP_266553.1 15672379 1114008 complement(402989..403690) 1 NC_002662.1 evidence experimental PMID:10708382; two-component systems; involved in acid stress resistance development; two-component system regulator 403690 llrC 1114008 llrC Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_266553.1 402989 R 272623 CDS NP_266554.1 15672380 1114009 403868..404503 1 NC_002662.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 404503 tmk 1114009 tmk Lactococcus lactis subsp. lactis Il1403 thymidylate kinase NP_266554.1 403868 D 272623 CDS NP_266555.1 15672381 1114010 404636..405496 1 NC_002662.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 405496 holB 1114010 holB Lactococcus lactis subsp. lactis Il1403 DNA polymerase III subunit delta' NP_266555.1 404636 D 272623 CDS NP_266556.1 15672382 1114011 405548..406330 1 NC_002662.1 hypothetical protein 406330 yeaC 1114011 yeaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266556.1 405548 D 272623 CDS NP_266557.1 15672383 1114012 406323..406649 1 NC_002662.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 406649 yeaD 1114012 yeaD Lactococcus lactis subsp. lactis Il1403 DNA replication intiation control protein YabA NP_266557.1 406323 D 272623 CDS NP_266558.2 30023988 1114013 406649..407524 1 NC_002662.1 hypothetical protein 407524 yeaE 1114013 yeaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266558.2 406649 D 272623 CDS NP_266559.1 15672385 1114014 complement(407601..407792) 1 NC_002662.1 hypothetical protein 407792 yeaF 1114014 yeaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266559.1 407601 R 272623 CDS NP_266560.1 15672386 1114015 complement(407855..408787) 1 NC_002662.1 fatty acid and phospholipid metabolism; mevalonate kinase 408787 yeaG 1114015 yeaG Lactococcus lactis subsp. lactis Il1403 mevalonate kinase NP_266560.1 407855 R 272623 CDS NP_266561.1 15672387 1114016 409093..410049 1 NC_002662.1 fatty acid and phospholipid metabolism; diphosphomevalonate decarboxylase 410049 yeaH 1114016 yeaH Lactococcus lactis subsp. lactis Il1403 diphosphomevalonate decarboxylase NP_266561.1 409093 D 272623 CDS NP_266562.1 15672388 1114017 410036..411025 1 NC_002662.1 fatty acid and phospholipid metabolism; mevalonate kinase 411025 yebA 1114017 yebA Lactococcus lactis subsp. lactis Il1403 mevalonate kinase NP_266562.1 410036 D 272623 CDS NP_266563.1 15672389 1114018 411078..412121 1 NC_002662.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 412121 yebB 1114018 yebB Lactococcus lactis subsp. lactis Il1403 isopentenyl pyrophosphate isomerase NP_266563.1 411078 D 272623 CDS NP_266564.1 15672390 1114019 412279..412899 1 NC_002662.1 evidence experimental PMID:7665513; cellular processes, detoxification; superoxide dismutase 412899 sodA 1114019 sodA Lactococcus lactis subsp. lactis Il1403 superoxide dismutase NP_266564.1 412279 D 272623 CDS NP_266565.1 15672391 1114020 413148..415502 1 NC_002662.1 adaptations and atypical conditions; peptide utilization during carbon starvation; carbon starvation protein 415502 cstA 1114020 cstA Lactococcus lactis subsp. lactis Il1403 carbon starvation protein NP_266565.1 413148 D 272623 CDS NP_266566.1 15672392 1114021 415804..417144 1 NC_002662.1 RNA processing; ATP-dependent RNA-binding protein with helicase activity; similar to other DEAD box family helicases; ATP-dependent RNA helicase 417144 rheB 1114021 rheB Lactococcus lactis subsp. lactis Il1403 ATP-dependent RNA helicase NP_266566.1 415804 D 272623 CDS NP_266567.1 15672393 1114022 417148..417732 1 NC_002662.1 hypothetical protein 417732 yebE 1114022 yebE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266567.1 417148 D 272623 CDS NP_266568.1 15672394 1114023 417888..418634 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 418634 yebF 1114023 yebF Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266568.1 417888 D 272623 CDS NP_266569.1 15672395 1114024 418876..419202 1 NC_002662.1 transport and binding protein; PTS system; PTS system cellobiose-specific transporter subunit IIB 419202 ptcB 1114024 ptcB Lactococcus lactis subsp. lactis Il1403 PTS system cellobiose-specific transporter subunit IIB NP_266569.1 418876 D 272623 CDS NP_266570.1 15672396 1114025 419287..419637 1 NC_002662.1 transport and binding protein; PTS system; PTS system cellobiose-specific transporter subunit IIA 419637 ptcA 1114025 ptcA Lactococcus lactis subsp. lactis Il1403 PTS system cellobiose-specific transporter subunit IIA NP_266570.1 419287 D 272623 CDS NP_266571.1 15672397 1114026 419728..420459 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 420459 yecA 1114026 yecA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266571.1 419728 D 272623 CDS NP_835291.1 30023989 1114027 420751..420945 1 NC_002662.1 hypothetical protein 420945 1114027 L200013 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835291.1 420751 D 272623 CDS NP_266572.1 15672398 1114028 420905..422074 1 NC_002662.1 transport and binding protein; PTS system; PTS system cellobiose-specific transporter subunit IIC 422074 ptcC 1114028 ptcC Lactococcus lactis subsp. lactis Il1403 PTS system cellobiose-specific transporter subunit IIC NP_266572.1 420905 D 272623 CDS NP_266573.1 15672399 1114029 422156..423592 1 NC_002662.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 423592 celA 1114029 celA Lactococcus lactis subsp. lactis Il1403 6-phospho-beta-glucosidase NP_266573.1 422156 D 272623 CDS NP_266574.1 15672400 1114030 423878..424159 1 NC_002662.1 hypothetical protein 424159 yecD 1114030 yecD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266574.1 423878 D 272623 CDS NP_266575.1 15672401 1114031 424521..426485 1 NC_002662.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 426485 ligA 1114031 ligA Lactococcus lactis subsp. lactis Il1403 NAD-dependent DNA ligase LigA NP_266575.1 424521 D 272623 CDS NP_266576.1 15672402 1114032 426638..427666 1 NC_002662.1 similar to YegS from E. coli; lipid kinase 427666 yecE 1114032 yecE Lactococcus lactis subsp. lactis Il1403 lipid kinase NP_266576.1 426638 D 272623 CDS NP_266577.1 15672403 1114033 427883..429019 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; multiple sugar ABC transporter ATP-binding protein 429019 msmK 1114033 msmK Lactococcus lactis subsp. lactis Il1403 multiple sugar ABC transporter ATP-binding protein NP_266577.1 427883 D 272623 CDS NP_266578.1 15672404 1114034 429327..432899 1 NC_002662.1 electron transport; oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin which reduces nitrogenase; pyruvate-flavodoxin oxidoreductase 432899 nifJ 1114034 nifJ Lactococcus lactis subsp. lactis Il1403 pyruvate-flavodoxin oxidoreductase NP_266578.1 429327 D 272623 CDS NP_266579.1 15672405 1114035 433205..434083 1 NC_002662.1 hypothetical protein 434083 yedA 1114035 yedA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266579.1 433205 D 272623 CDS NP_266580.1 15672406 1114036 435077..436435 1 NC_002662.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 436435 glmM 1114036 glmM Lactococcus lactis subsp. lactis Il1403 phosphoglucosamine mutase NP_266580.1 435077 D 272623 CDS NP_266581.1 15672407 1114037 complement(436511..437227) 1 NC_002662.1 GntR family transcriptional regulator 437227 rgrA 1114037 rgrA Lactococcus lactis subsp. lactis Il1403 GntR family transcriptional regulator NP_266581.1 436511 R 272623 CDS NP_266582.1 15672408 1114038 437338..437823 1 NC_002662.1 similar to C part of PTS protein; hypothetical protein 437823 yedE 1114038 yedE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266582.1 437338 D 272623 CDS NP_266583.2 30023990 1114039 437921..439525 1 NC_002662.1 transport and binding protein; PTS system; PTS system beta-glucoside-specific transporter subunit IIABC 439525 yedF 1114039 yedF Lactococcus lactis subsp. lactis Il1403 PTS system beta-glucoside-specific transporter subunit IIABC NP_266583.2 437921 D 272623 CDS NP_266584.1 15672410 1114040 439593..441902 1 NC_002662.1 similar to Lactococcus lactis ATCC 19435 protein Y18267; hypothetical protein 441902 yeeA 1114040 yeeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266584.1 439593 D 272623 CDS NP_266585.1 15672411 1114041 442048..442713 1 NC_002662.1 evidence experimental PMID:9084169; glycolysis; beta-phosphoglucomutase 442713 pgmB 1114041 pgmB Lactococcus lactis subsp. lactis Il1403 beta-phosphoglucomutase NP_266585.1 442048 D 272623 CDS NP_266586.1 15672412 1114042 complement(442772..443578) 1 NC_002662.1 energy metabolism, sugars; similar to beta-1,4-D-xylanase of Butyrivibrio fibrisolvens; sugar hydrolase 443578 yeeB 1114042 yeeB Lactococcus lactis subsp. lactis Il1403 sugar hydrolase NP_266586.1 442772 R 272623 CDS NP_266587.1 15672413 1114043 443651..444346 1 NC_002662.1 hypothetical protein 444346 yeeC 1114043 yeeC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266587.1 443651 D 272623 CDS NP_266588.1 15672414 1114044 444288..444488 1 NC_002662.1 hypothetical protein 444488 yeeD 1114044 yeeD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266588.1 444288 D 272623 CDS NP_266589.1 15672415 1114045 444575..445000 1 NC_002662.1 hypothetical protein 445000 yeeE 1114045 yeeE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266589.1 444575 D 272623 CDS NP_266590.1 15672416 1114046 444997..445515 1 NC_002662.1 hypothetical protein 445515 yeeF 1114046 yeeF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266590.1 444997 D 272623 CDS NP_266591.1 15672417 1114047 445619..447004 1 NC_002662.1 belongs to LytR family; transcriptional regulator 447004 yeeG 1114047 yeeG Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266591.1 445619 D 272623 CDS NP_266592.1 15672418 1114048 complement(447236..448369) 1 NC_002662.1 prophage pi1 protein 01; similar to integrase of Lactococcus lactis phage BK5-T; integrase 448369 pi101 1114048 pi101 Lactococcus lactis subsp. lactis Il1403 integrase NP_266592.1 447236 R 272623 CDS NP_266593.1 15672419 1114049 complement(448492..449070) 1 NC_002662.1 similar to orf3 of Lactococcus lactis phage TP901-1; prophage pi1 protein 02 449070 pi102 1114049 pi102 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 02 NP_266593.1 448492 R 272623 CDS NP_266594.1 15672420 1114050 complement(449154..449990) 1 NC_002662.1 transcription regulator; evidence experimental PMID:8730874; similar to the repressor protein Rro of Lactococcus lactis phage r1t. cI type regulator; prophage pi1 protein 03 449990 pi103 1114050 pi103 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 03 NP_266594.1 449154 R 272623 CDS NP_266595.1 15672421 1114051 450207..450389 1 NC_002662.1 transcription regulator; similar to BK5-T phage repressor protein Cro; prophage pi1 protein 04 450389 pi104 1114051 pi104 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 04 NP_266595.1 450207 D 272623 CDS NP_266596.1 15672422 1114052 450421..450654 1 NC_002662.1 prophage pi1 protein 05 450654 pi105 1114052 pi105 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 05 NP_266596.1 450421 D 272623 CDS NP_266597.1 15672423 1114053 450763..450912 1 NC_002662.1 prophage pi1 protein 06 450912 pi106 1114053 pi106 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 06 NP_266597.1 450763 D 272623 CDS NP_266598.1 15672424 1114054 451007..451414 1 NC_002662.1 similar to tec gene product of bacteriophage r1t; prophage pi1 protein 07 451414 pi107 1114054 pi107 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 07 NP_266598.1 451007 D 272623 CDS NP_266599.1 15672425 1114055 451426..452181 1 NC_002662.1 similar to orf5 of the phage r1t; prophage pi1 protein 08 452181 pi108 1114055 pi108 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 08 NP_266599.1 451426 D 272623 CDS NP_266600.1 15672426 1114056 452194..452523 1 NC_002662.1 similar to orf6 of bacteriophage r1t; prophage pi1 protein 09 452523 pi109 1114056 pi109 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 09 NP_266600.1 452194 D 272623 CDS NP_835292.1 30023991 1114057 452524..452694 1 NC_002662.1 hypothetical protein 452694 1114057 L200014 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835292.1 452524 D 272623 CDS NP_266601.1 15672427 1114058 452738..452911 1 NC_002662.1 transcription regulator; similar to orf8 of bacteriophage r1t, similar to Cro repressor protein of the phage BK5-T; prophage pi1 protein 10 452911 pi110 1114058 pi110 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 10 NP_266601.1 452738 D 272623 CDS NP_266602.1 15672428 1114059 453010..453816 1 NC_002662.1 prophage pi1 protein 11; similar to a recombinase of the Listeria monocytogenes bacteriophage A118; recombinase 453816 pi111 1114059 pi111 Lactococcus lactis subsp. lactis Il1403 recombinase NP_266602.1 453010 D 272623 CDS NP_266603.1 15672429 1114060 453816..454592 1 NC_002662.1 prophage pi1 protein 12 454592 pi112 1114060 pi112 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 12 NP_266603.1 453816 D 272623 CDS NP_266604.2 30023992 1114061 454820..455596 1 NC_002662.1 prophage pi1 protein 13; similar to a replisome organiser protein Rep2009 of the bacteriophage Tuc2009; replisome organizer 455596 pi113 1114061 pi113 Lactococcus lactis subsp. lactis Il1403 replisome organizer NP_266604.2 454820 D 272623 CDS NP_266605.2 30023993 1114062 455606..456490 1 NC_002662.1 prophage pi1 protein 14; similar to the orf12 of the phage r1t; functional equivalent to DnaC of Escherichia coli or DnaI of Bacillus subtilis, which are required for chromosomal replication; DNA replication protein 456490 pi114 1114062 pi114 Lactococcus lactis subsp. lactis Il1403 DNA replication protein NP_266605.2 455606 D 272623 CDS NP_835293.1 30023994 1114063 456487..456651 1 NC_002662.1 similar to bacteriophage bIL309 Orf16; hypothetical protein 456651 1114063 L200015 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835293.1 456487 D 272623 CDS NP_266606.1 15672432 1114064 456575..457051 1 NC_002662.1 prophage pi1 protein 15 457051 pi115 1114064 pi115 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 15 NP_266606.1 456575 D 272623 CDS NP_835294.1 30023995 1114065 457159..457323 1 NC_002662.1 similar to bacteriophage bIL309 Orf18; hypothetical protein 457323 1114065 L200016 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835294.1 457159 D 272623 CDS NP_266607.1 15672433 1114066 457298..457660 1 NC_002662.1 similar to orf18 of bacteriophage r1t; prophage pi1 protein 16 457660 pi116 1114066 pi116 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 16 NP_266607.1 457298 D 272623 CDS NP_266608.1 15672434 1114067 457854..458060 1 NC_002662.1 prophage pi1 protein 17 458060 pi117 1114067 pi117 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 17 NP_266608.1 457854 D 272623 CDS NP_266609.1 15672435 1114068 458053..458325 1 NC_002662.1 prophage pi1 protein 18 458325 pi118 1114068 pi118 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 18 NP_266609.1 458053 D 272623 CDS NP_266610.1 15672436 1114069 458322..458876 1 NC_002662.1 similar to orf24 of the bacteriophage Tuc2009; prophage pi1 protein 19 458876 pi119 1114069 pi119 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 19 NP_266610.1 458322 D 272623 CDS NP_266611.1 15672437 1114070 458873..459292 1 NC_002662.1 prophage pi1 protein 16; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t; deoxyuridine 5'-triphosphate nucleotidohydrolase 459292 pi120 1114070 pi120 Lactococcus lactis subsp. lactis Il1403 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_266611.1 458873 D 272623 CDS NP_266612.1 15672438 1114071 459292..459582 1 NC_002662.1 prophage pi1 protein 21 459582 pi121 1114071 pi121 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 21 NP_266612.1 459292 D 272623 CDS NP_266613.1 15672439 1114072 459579..459743 1 NC_002662.1 similar to orf17 of bacteriophage o1205; prophage pi1 protein 22 459743 pi122 1114072 pi122 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 22 NP_266613.1 459579 D 272623 CDS NP_835295.1 30023996 1114073 459792..459935 1 NC_002662.1 similar to bacteriophage bIL309 Orf27; hypothetical protein 459935 1114073 L200017 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835295.1 459792 D 272623 CDS NP_266614.1 15672440 1114074 459932..460114 1 NC_002662.1 similar to orfx from lactococcal bacteriophage 712; prophage pi1 protein 23 460114 pi123 1114074 pi123 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 23 NP_266614.1 459932 D 272623 CDS NP_835296.1 30023997 1114075 460181..460288 1 NC_002662.1 hypothetical protein 460288 1114075 L200018 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835296.1 460181 D 272623 CDS NP_266615.1 15672441 1114076 460296..460481 1 NC_002662.1 prophage pi1 protein 24 460481 pi124 1114076 pi124 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 24 NP_266615.1 460296 D 272623 CDS NP_266616.1 15672442 1114077 complement(460534..460743) 1 NC_002662.1 prophage pi1 protein 25 460743 pi125 1114077 pi125 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 25 NP_266616.1 460534 R 272623 CDS NP_266617.1 15672443 1114078 460956..461249 1 NC_002662.1 similar to orf4 of abiN locus from Lactococcus lactis S114 accession number Y11901; prophage pi1 protein 26 461249 pi126 1114078 pi126 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 26 NP_266617.1 460956 D 272623 CDS NP_266618.1 15672444 1114079 461360..461605 1 NC_002662.1 similar to Orf20 of S.thermophilus bacteriophage o1205; prophage pi1 protein 27 461605 pi127 1114079 pi127 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 27 NP_266618.1 461360 D 272623 CDS NP_266619.1 15672445 1114080 461650..462039 1 NC_002662.1 similar to orf4 of abiN locus from Lactococcus lactis S114 accession number Y11901; prophage pi1 protein 28 462039 pi128 1114080 pi128 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 28 NP_266619.1 461650 D 272623 CDS NP_266620.1 15672446 1114081 462041..462439 1 NC_002662.1 similar to the 64 protein (GP64) from Mycobacteriophage l5; prophage pi1 protein 29 462439 pi129 1114081 pi129 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 29 NP_266620.1 462041 D 272623 CDS NP_266621.1 15672447 1114082 462436..462588 1 NC_002662.1 prophage pi1 protein 30 462588 pi130 1114082 pi130 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 30 NP_266621.1 462436 D 272623 CDS NP_266622.1 15672448 1114083 462765..463187 1 NC_002662.1 similar to orf6 of abiN locus from Lactococcus lactis S114 accession number Y11901; prophage pi1 protein 31 463187 pi131 1114083 pi131 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 31 NP_266622.1 462765 D 272623 CDS NP_266623.2 30023998 1114084 463425..463928 1 NC_002662.1 prophage pi1 protein 32 463928 pi132 1114084 pi132 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 32 NP_266623.2 463425 D 272623 CDS NP_266624.1 15672450 1114085 464045..464497 1 NC_002662.1 prophage pi1 protein 33; similar to small subunit (orf152 gp) of terminase from Streptococcus thermophilus bacteriophage Sfi21; terminase small subunit 464497 pi133 1114085 pi133 Lactococcus lactis subsp. lactis Il1403 terminase small subunit NP_266624.1 464045 D 272623 CDS NP_266625.1 15672451 1114086 464497..466311 1 NC_002662.1 prophage pi1 protein 34; similar to large subunit (orf623 gp) of terminase from Streptococcus thermophilus bacteriophage Sfi21; terminase large subunit 466311 pi134 1114086 pi134 Lactococcus lactis subsp. lactis Il1403 terminase large subunit NP_266625.1 464497 D 272623 CDS NP_835297.1 30023999 1114087 466320..466484 1 NC_002662.1 similar to bacteriophage bIL309 Orf40; hypothetical protein 466484 1114087 L200019 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835297.1 466320 D 272623 CDS NP_266626.1 15672452 1114088 466481..467560 1 NC_002662.1 similar to a hypothetical protein of Lactobacillus bacteriophage phi adh accession number AJ131519; prophage pi1 protein 35 467560 pi135 1114088 pi135 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 35 NP_266626.1 466481 D 272623 CDS NP_266627.1 15672453 1114089 467560..468147 1 NC_002662.1 prophage pi1 protein 36; similar to orf26 of Bacillus subtilis bacteriophage phi-105; prohead protease 468147 pi136 1114089 pi136 Lactococcus lactis subsp. lactis Il1403 prohead protease NP_266627.1 467560 D 272623 CDS NP_266628.1 15672454 1114090 468137..469450 1 NC_002662.1 prophage pi1 protein 37; similar to orf27 of Bacillus subtilis bacteriophage phi-105, encoding capsid protein; capsid protein 469450 pi137 1114090 pi137 Lactococcus lactis subsp. lactis Il1403 capsid protein NP_266628.1 468137 D 272623 CDS NP_266629.1 15672455 1114091 469461..469766 1 NC_002662.1 prophage pi1 protein 38 469766 pi138 1114091 pi138 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 38 NP_266629.1 469461 D 272623 CDS NP_266630.1 15672456 1114092 469753..470088 1 NC_002662.1 similar to head-tail joining protein (orf10) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 39 470088 pi139 1114092 pi139 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 39 NP_266630.1 469753 D 272623 CDS NP_266631.1 15672457 1114093 470085..470570 1 NC_002662.1 tail component; similar to tail component protein (Orf11) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 40 470570 pi140 1114093 pi140 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 40 NP_266631.1 470085 D 272623 CDS NP_266632.1 15672458 1114094 470567..470962 1 NC_002662.1 tail component; similar to a tail component protein (Orf12) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 41 470962 pi141 1114094 pi141 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 41 NP_266632.1 470567 D 272623 CDS NP_266633.1 15672459 1114095 470964..471569 1 NC_002662.1 prophage pi1 protein 42; similar to small major structural protein of Streptococcus thermophilus phage phi7201 accession number AF001793); small major structural protein 471569 pi142 1114095 pi142 Lactococcus lactis subsp. lactis Il1403 small major structural protein NP_266633.1 470964 D 272623 CDS NP_266634.1 15672460 1114096 471629..471973 1 NC_002662.1 prophage pi1 protein 43 471973 pi143 1114096 pi143 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 43 NP_266634.1 471629 D 272623 CDS NP_266635.1 15672461 1114097 472143..475982 1 NC_002662.1 tail component; similar to tail component protein (Orf15) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 44 475982 pi144 1114097 pi144 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 44 NP_266635.1 472143 D 272623 CDS NP_266636.1 15672462 1114098 475985..477520 1 NC_002662.1 tail component; similar to tail component protein (Orf17) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 45 477520 pi145 1114098 pi145 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 45 NP_266636.1 475985 D 272623 CDS NP_266637.1 15672463 1114099 477520..481845 1 NC_002662.1 tail component; similar to tail-host specificity protein (Orf18) of Streptococcus thermophilus bacteriophage DT1; prophage pi1 protein 46 481845 pi146 1114099 pi146 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 46 NP_266637.1 477520 D 272623 CDS NP_266638.1 15672464 1114100 481865..482191 1 NC_002662.1 hypothetical protein 482191 pi147 1114100 pi147 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266638.1 481865 D 272623 CDS NP_266639.1 15672465 1114101 482178..482465 1 NC_002662.1 similar to holin of Staphylococcus aureus bacteriophage phi PVL, similar to orf95 of Lactococcus lactis phage BK5-T; prophage pi1 protein 48 482465 pi148 1114101 pi148 Lactococcus lactis subsp. lactis Il1403 prophage pi1 protein 48 NP_266639.1 482178 D 272623 CDS NP_266640.1 15672466 1114102 482465..483244 1 NC_002662.1 prophage pi1 protein 49; similar to orf259 of Lactococcus lactis phage BK5-T; muramidase 483244 pi149 1114102 pi149 Lactococcus lactis subsp. lactis Il1403 muramidase NP_266640.1 482465 D 272623 CDS NP_266641.1 15672467 1114103 complement(483349..483552) 1 NC_002662.1 hypothetical protein 483552 yeiD 1114103 yeiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266641.1 483349 R 272623 CDS NP_266642.1 15672468 1114104 484226..484987 1 NC_002662.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 484987 truA 1114104 truA Lactococcus lactis subsp. lactis Il1403 tRNA pseudouridine synthase A NP_266642.1 484226 D 272623 CDS NP_266643.1 15672469 1114105 485020..485808 1 NC_002662.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 485808 thiD2 1114105 thiD2 Lactococcus lactis subsp. lactis Il1403 phosphomethylpyrimidine kinase NP_266643.1 485020 D 272623 CDS NP_266644.1 15672470 1114106 485857..486348 1 NC_002662.1 hypothetical protein 486348 yeiE 1114106 yeiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266644.1 485857 D 272623 CDS NP_266645.1 15672471 1114107 486329..486871 1 NC_002662.1 similar to YwlG protein from Bacillus subtilis; hypothetical protein 486871 yeiF 1114107 yeiF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266645.1 486329 D 272623 CDS NP_266646.1 15672472 1114108 486872..488008 1 NC_002662.1 energy metabolism; similar to several amino acid aminotransferases; YeiG 488008 yeiG 1114108 yeiG Lactococcus lactis subsp. lactis Il1403 YeiG NP_266646.1 486872 D 272623 CDS NP_266647.1 15672473 1114109 488243..489850 1 NC_002662.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 489850 pyrG 1114109 pyrG Lactococcus lactis subsp. lactis Il1403 CTP synthetase NP_266647.1 488243 D 272623 CDS NP_266648.1 15672474 1114111 complement(490934..491806) 1 NC_002662.1 hypothetical protein 491806 yejC 1114111 yejC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266648.1 490934 R 272623 CDS NP_266649.1 15672475 1114112 complement(492452..492931) 1 NC_002662.1 hypothetical protein 492931 yejD 1114112 yejD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266649.1 492452 R 272623 CDS YP_008998700.1 574739634 1114114 complement(493469..494122) 1 NC_002662.1 deoxynucleoside kinase 494122 dukA 1114114 dukA Lactococcus lactis subsp. lactis Il1403 deoxynucleoside kinase YP_008998700.1 493469 R 272623 CDS NP_266652.1 15672478 1114115 494602..497784 1 NC_002662.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 497784 dnaE 1114115 dnaE Lactococcus lactis subsp. lactis Il1403 DNA polymerase III DnaE NP_266652.1 494602 D 272623 CDS NP_266653.1 15672479 1114116 complement(497815..498468) 1 NC_002662.1 cell killing; hemolysin like protein 498468 hly 1114116 hly Lactococcus lactis subsp. lactis Il1403 hemolysin like protein NP_266653.1 497815 R 272623 CDS NP_266654.1 15672480 1114117 498649..499506 1 NC_002662.1 similar to DegV of Bacillus subtilis; hypothetical protein 499506 yejH 1114117 yejH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266654.1 498649 D 272623 CDS NP_266655.2 30024000 1114118 499499..500359 1 NC_002662.1 hypothetical protein 500359 yejI 1114118 yejI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266655.2 499499 D 272623 CDS NP_266656.1 15672482 1114119 500356..501567 1 NC_002662.1 similar to glycosyl hyrolases; hypothetical protein 501567 yejJ 1114119 yejJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266656.1 500356 D 272623 CDS NP_266657.1 15672483 1114120 501577..502233 1 NC_002662.1 hypothetical protein 502233 yfaA 1114120 yfaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266657.1 501577 D 272623 CDS NP_266658.1 15672484 1114121 502338..502613 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; HU like DNA-binding protein 502613 hslA 1114121 hslA Lactococcus lactis subsp. lactis Il1403 HU like DNA-binding protein NP_266658.1 502338 D 272623 CDS NP_266659.1 15672485 1114122 complement(502723..503871) 1 NC_002662.1 prophage ps2 protein 01; integrase 503871 ps201 1114122 ps201 Lactococcus lactis subsp. lactis Il1403 integrase NP_266659.1 502723 R 272623 CDS NP_266660.1 15672486 1114123 complement(503995..504486) 1 NC_002662.1 prophage ps2 protein 02 504486 ps202 1114123 ps202 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 02 NP_266660.1 503995 R 272623 CDS NP_266661.1 15672487 1114124 complement(504540..504836) 1 NC_002662.1 prophage ps2 protein 03 504836 ps203 1114124 ps203 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 03 NP_266661.1 504540 R 272623 CDS NP_266662.1 15672488 1114125 complement(504883..505470) 1 NC_002662.1 similar to gp17v protein of Escherichia coli bacteriophage KVP40; prophage ps2 protein 04 505470 ps204 1114125 ps204 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 04 NP_266662.1 504883 R 272623 CDS NP_266663.1 15672489 1114126 complement(505482..505850) 1 NC_002662.1 prophage ps2 protein 05; similar to Rad protein of Lactobacillus bacteriophage phi adh; transcription repressor 505850 ps205 1114126 ps205 Lactococcus lactis subsp. lactis Il1403 transcription repressor NP_266663.1 505482 R 272623 CDS NP_266664.1 15672490 1114127 506144..506335 1 NC_002662.1 similar to Orf65a of Lactobacillus bacteriophage phi adh; prophage ps2 protein 06 506335 ps206 1114127 ps206 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 06 NP_266664.1 506144 D 272623 CDS NP_266665.1 15672491 1114128 506351..506611 1 NC_002662.1 prophage ps2 protein 07; similar to excisionase of Streptococcus pneumoniae transposon Tn5252; excisionase 506611 ps207 1114128 ps207 Lactococcus lactis subsp. lactis Il1403 excisionase NP_266665.1 506351 D 272623 CDS NP_266666.1 15672492 1114129 506770..506964 1 NC_002662.1 prophage ps2 protein 08 506964 ps208 1114129 ps208 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 08 NP_266666.1 506770 D 272623 CDS NP_266667.1 15672493 1114130 506969..507394 1 NC_002662.1 prophage ps2 protein 09 507394 ps209 1114130 ps209 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 09 NP_266667.1 506969 D 272623 CDS NP_266668.1 15672494 1114131 507429..507668 1 NC_002662.1 prophage ps2 protein 10 507668 ps210 1114131 ps210 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 10 NP_266668.1 507429 D 272623 CDS NP_266669.1 15672495 1114132 507665..507919 1 NC_002662.1 prophage ps2 protein 11 507919 ps211 1114132 ps211 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 11 NP_266669.1 507665 D 272623 CDS NP_266670.1 15672496 1114133 507916..508110 1 NC_002662.1 prophage ps2 protein 12 508110 ps212 1114133 ps212 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 12 NP_266670.1 507916 D 272623 CDS NP_266671.1 15672497 1114134 508097..508423 1 NC_002662.1 prophage ps2 protein 13 508423 ps213 1114134 ps213 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 13 NP_266671.1 508097 D 272623 CDS NP_266672.1 15672498 1114135 508431..509009 1 NC_002662.1 prophage ps2 protein 14 509009 ps214 1114135 ps214 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 14 NP_266672.1 508431 D 272623 CDS NP_266673.1 15672499 1114136 509002..510444 1 NC_002662.1 similar to Orf11 of Staphlococcus aureus transposon Tn557; prophage ps2 protein 15 510444 ps215 1114136 ps215 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 15 NP_266673.1 509002 D 272623 CDS NP_266674.1 15672500 1114137 510596..511180 1 NC_002662.1 prophage ps2 protein 16 511180 ps216 1114137 ps216 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 16 NP_266674.1 510596 D 272623 CDS NP_266675.1 15672501 1114138 511357..511542 1 NC_002662.1 hypothetical protein 511542 yfbB 1114138 yfbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266675.1 511357 D 272623 CDS NP_266676.1 15672502 1114139 511569..512177 1 NC_002662.1 prophage ps2 protein 18 512177 ps218 1114139 ps218 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 18 NP_266676.1 511569 D 272623 CDS NP_266677.1 15672503 1114140 512186..512776 1 NC_002662.1 similar to Orf26 of Bacillus subtilis bacteriophage phi-105; prophage ps2 protein 19 512776 ps219 1114140 ps219 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 19 NP_266677.1 512186 D 272623 CDS NP_266678.1 15672504 1114141 512992..513321 1 NC_002662.1 prophage ps2 protein 20 513321 ps220 1114141 ps220 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 20 NP_266678.1 512992 D 272623 CDS NP_266679.1 15672505 1114142 513422..513742 1 NC_002662.1 prophage ps2 protein 21 513742 ps221 1114142 ps221 Lactococcus lactis subsp. lactis Il1403 prophage ps2 protein 21 NP_266679.1 513422 D 272623 CDS NP_266680.1 15672506 1114143 complement(514066..514338) 1 NC_002662.1 hypothetical protein 514338 yfbG 1114143 yfbG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266680.1 514066 R 272623 CDS NP_266681.1 15672507 1114144 514455..514676 1 NC_002662.1 hypothetical protein 514676 yfbH 1114144 yfbH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266681.1 514455 D 272623 CDS NP_266682.1 15672508 1114145 514845..515333 1 NC_002662.1 hypothetical protein 515333 yfbI 1114145 yfbI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266682.1 514845 D 272623 CDS NP_266683.1 15672509 1114146 515299..515865 1 NC_002662.1 hypothetical protein 515865 yfbJ 1114146 yfbJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266683.1 515299 D 272623 CDS NP_266684.1 15672510 1114147 516184..516366 1 NC_002662.1 hypothetical protein 516366 yfbK 1114147 yfbK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266684.1 516184 D 272623 CDS NP_266685.1 15672511 1114148 517114..517314 1 NC_002662.1 adaptations and atypical conditions; cold-shock domain family (CSD); cold shock protein D 517314 cspD 1114148 cspD Lactococcus lactis subsp. lactis Il1403 cold shock protein D NP_266685.1 517114 D 272623 CDS NP_266686.1 15672512 1114149 complement(517855..518352) 1 NC_002662.1 regulatory function; transcriptional regulator 518352 yfbM 1114149 yfbM Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266686.1 517855 R 272623 CDS NP_266687.1 15672513 1114150 518499..519008 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; 6-O-methylguanine DNA methyltransferase 519008 ogt 1114150 ogt Lactococcus lactis subsp. lactis Il1403 6-O-methylguanine DNA methyltransferase NP_266687.1 518499 D 272623 CDS NP_266688.1 15672514 1114151 519022..519582 1 NC_002662.1 methylphosphotriester-DNA alkyltransferase 519582 adaA 1114151 adaA Lactococcus lactis subsp. lactis Il1403 methylphosphotriester-DNA alkyltransferase NP_266688.1 519022 D 272623 CDS NP_266689.1 15672515 1114152 519676..520485 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 520485 yfcA 1114152 yfcA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266689.1 519676 D 272623 CDS NP_266690.1 15672516 1114153 520482..521207 1 NC_002662.1 transport and binding protein; ABC transporter permease 521207 yfcB 1114153 yfcB Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266690.1 520482 D 272623 CDS NP_266691.1 15672517 1114154 521270..521728 1 NC_002662.1 hypothetical protein 521728 yfcC 1114154 yfcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266691.1 521270 D 272623 CDS NP_266692.1 15672518 1114155 521725..522102 1 NC_002662.1 hypothetical protein 522102 yfcD 1114155 yfcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266692.1 521725 D 272623 CDS NP_266693.1 15672519 1114156 522216..523361 1 NC_002662.1 energy metabolism, electron transport; similar to NifZ of Bacillus subtilis; cysteine sulfinate desulfinase/cysteine desulfurase, evidenced by COGnitor; pyridoxal-phosphate dependent aminotransferase 523361 nifZ 1114156 nifZ Lactococcus lactis subsp. lactis Il1403 pyridoxal-phosphate dependent aminotransferase NP_266693.1 522216 D 272623 CDS NP_266694.1 15672520 1114157 523468..524346 1 NC_002662.1 hypothetical protein 524346 yfcF 1114157 yfcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266694.1 523468 D 272623 CDS NP_266695.1 15672521 1114158 complement(524403..526052) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; probably a substrate binding protein of an oligopeptide or aminoacid ABC transporter; peptide-binding protein 526052 yfcG 1114158 yfcG Lactococcus lactis subsp. lactis Il1403 peptide-binding protein NP_266695.1 524403 R 272623 CDS NP_266696.1 15672522 1114159 complement(526263..527195) 1 NC_002662.1 serine family; cysteine synthase 527195 cysM 1114159 cysM Lactococcus lactis subsp. lactis Il1403 cysteine synthase NP_266696.1 526263 R 272623 CDS NP_266697.1 15672523 1114160 527413..528498 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis; N-acetylmuramidase 528498 acmD 1114160 acmD Lactococcus lactis subsp. lactis Il1403 N-acetylmuramidase NP_266697.1 527413 D 272623 CDS NP_266698.1 15672524 1114161 complement(528537..529169) 1 NC_002662.1 hypothetical protein 529169 yfcI 1114161 yfcI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266698.1 528537 R 272623 CDS NP_266699.1 15672525 1114162 complement(529170..531164) 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; penicillin-binding protein 1A 531164 ponA 1114162 ponA Lactococcus lactis subsp. lactis Il1403 penicillin-binding protein 1A NP_266699.1 529170 R 272623 CDS NP_266700.1 15672526 1114163 complement(531232..531873) 1 NC_002662.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 531873 recU 1114163 recU Lactococcus lactis subsp. lactis Il1403 Holliday junction-specific endonuclease NP_266700.1 531232 R 272623 CDS NP_266701.1 15672527 1114164 531954..532478 1 NC_002662.1 hypothetical protein 532478 yfdB 1114164 yfdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266701.1 531954 D 272623 CDS NP_266702.1 15672528 1114165 532638..533024 1 NC_002662.1 hypothetical protein 533024 yfdC 1114165 yfdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266702.1 532638 D 272623 CDS NP_266703.1 15672529 1114166 533116..533397 1 NC_002662.1 similar to YktA protein of Bacillus subtilis; hypothetical protein 533397 yfdD 1114166 yfdD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266703.1 533116 D 272623 CDS NP_266704.2 30024001 1114167 533381..534142 1 NC_002662.1 similar to myo-inositol monophosphatases; hypothetical protein 534142 yfdE 1114167 yfdE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266704.2 533381 D 272623 CDS NP_266705.1 15672531 1114168 534233..535516 1 NC_002662.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 535516 murA2 1114168 murA2 Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_266705.1 534233 D 272623 CDS NP_266706.1 15672532 1114169 535516..535710 1 NC_002662.1 hypothetical protein 535710 yfdG 1114169 yfdG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266706.1 535516 D 272623 CDS NP_266707.1 15672533 1114170 535867..537150 1 NC_002662.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 537150 tig 1114170 tig Lactococcus lactis subsp. lactis Il1403 trigger factor NP_266707.1 535867 D 272623 CDS NP_266708.1 15672534 1114171 544010..545923 1 NC_002662.1 synthesizes RNA primers at the replication forks; DNA primase 545923 dnaG 1114171 dnaG Lactococcus lactis subsp. lactis Il1403 DNA primase NP_266708.1 544010 D 272623 CDS NP_266709.1 15672535 1114172 546000..547343 1 NC_002662.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 547343 rpoD 1114172 rpoD Lactococcus lactis subsp. lactis Il1403 RNA polymerase sigma factor RpoD NP_266709.1 546000 D 272623 CDS NP_266710.1 15672536 1114173 547458..548201 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 548201 yfeA 1114173 yfeA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266710.1 547458 D 272623 CDS NP_266711.1 15672537 1114174 548432..549733 1 NC_002662.1 transport and binding protein, carbohydrates, organic alcohols and acids; similar to Lactococcus lactishexose phosphate transport in Accession Number X71493; glycerol-3-phosphatase transporter 549733 glpT 1114174 glpT Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphatase transporter NP_266711.1 548432 D 272623 CDS NP_266712.1 15672538 1114175 550016..550354 1 NC_002662.1 hypothetical protein 550354 yffA 1114175 yffA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266712.1 550016 D 272623 CDS NP_266713.1 15672539 1114176 550405..552651 1 NC_002662.1 evidence experimental PMID:10094684; adaptations and atypical conditions; CLPC subfamily; ATP-dependent protease ATP-binding subunit 552651 clpE 1114176 clpE Lactococcus lactis subsp. lactis Il1403 ATP-dependent protease ATP-binding subunit NP_266713.1 550405 D 272623 CDS NP_266714.1 15672540 1114177 complement(553073..553543) 1 NC_002662.1 hypothetical protein 553543 yffB 1114177 yffB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266714.1 553073 R 272623 CDS NP_266715.1 15672541 1114178 553716..554729 1 NC_002662.1 evidence experimental PMID:7773380; glycolysis; glyceraldehyde 3-phosphate dehydrogenase 554729 gapA 1114178 gapA Lactococcus lactis subsp. lactis Il1403 glyceraldehyde 3-phosphate dehydrogenase NP_266715.1 553716 D 272623 CDS NP_266716.1 15672542 1114179 complement(554872..555507) 1 NC_002662.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 555507 def 1114179 def Lactococcus lactis subsp. lactis Il1403 peptide deformylase NP_266716.1 554872 R 272623 CDS NP_266717.1 15672543 1114180 555661..556116 1 NC_002662.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 556116 yffD 1114180 yffD Lactococcus lactis subsp. lactis Il1403 dinucleoside polyphosphate hydrolase NP_266717.1 555661 D 272623 CDS NP_266718.1 15672544 1114181 556127..558205 1 NC_002662.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 558205 uvrB 1114181 uvrB Lactococcus lactis subsp. lactis Il1403 excinuclease ABC subunit B NP_266718.1 556127 D 272623 CDS NP_266719.1 15672545 1114182 558401..559210 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; glutamate or arginine ABC transporter substrate binding protein 559210 gltS 1114182 gltS Lactococcus lactis subsp. lactis Il1403 glutamate or arginine ABC transporter substrate binding protein NP_266719.1 558401 D 272623 CDS NP_266720.1 15672546 1114183 559225..560343 1 NC_002662.1 glutamate family; fifth step in arginine biosynthesis; acetylornithine deacetylase 560343 argE 1114183 argE Lactococcus lactis subsp. lactis Il1403 acetylornithine deacetylase NP_266720.1 559225 D 272623 CDS NP_266721.1 15672547 1114184 complement(560411..560866) 1 NC_002662.1 fatty acid and phospholipid metabolism; (3R)-hydroxymyristoyl-ACP dehydratase 560866 fabZ1 1114184 fabZ1 Lactococcus lactis subsp. lactis Il1403 (3R)-hydroxymyristoyl-ACP dehydratase NP_266721.1 560411 R 272623 CDS NP_266722.1 15672548 1114185 561142..561894 1 NC_002662.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 561894 fabI 1114185 fabI Lactococcus lactis subsp. lactis Il1403 enoyl-ACP reductase NP_266722.1 561142 D 272623 CDS NP_266723.1 15672549 1114186 562156..562563 1 NC_002662.1 hypothetical protein 562563 yfgC 1114186 yfgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266723.1 562156 D 272623 CDS NP_266724.1 15672550 1114188 563253..564173 1 NC_002662.1 transport and binding protein; ABC transporter permease 564173 yfgF 1114188 yfgF Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266724.1 563253 D 272623 CDS NP_266725.1 15672551 1114189 complement(564298..565221) 1 NC_002662.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 565221 yfgG 1114189 yfgG Lactococcus lactis subsp. lactis Il1403 OxaA-like protein precursor NP_266725.1 564298 R 272623 CDS NP_266726.1 15672552 1114190 complement(565435..566193) 1 NC_002662.1 hypothetical protein 566193 yfgH 1114190 yfgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266726.1 565435 R 272623 CDS NP_266727.1 15672553 1114191 complement(566288..566878) 1 NC_002662.1 similar to several membrane proteins; hypothetical protein 566878 yfgL 1114191 yfgL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266727.1 566288 R 272623 CDS NP_266728.1 15672554 1114192 complement(566895..567431) 1 NC_002662.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 567431 dfpA 1114192 dfpA Lactococcus lactis subsp. lactis Il1403 phosphopantothenoylcysteine decarboxylase NP_266728.1 566895 R 272623 CDS NP_266729.1 15672555 1114193 complement(567424..568119) 1 NC_002662.1 biosynthesis of cofactors; prosthetic groups, and carriers; apparently the middle part of the protein; probably involved in pantothenate metabolism; phosphopantothenate--cysteine ligase 568119 dfpB 1114193 dfpB Lactococcus lactis subsp. lactis Il1403 phosphopantothenate--cysteine ligase NP_266729.1 567424 R 272623 CDS NP_266730.1 15672556 1114194 complement(568265..568450) 1 NC_002662.1 central intermediary metabolism; 4-oxalocrotonate tautomerase 568450 xylH 1114194 xylH Lactococcus lactis subsp. lactis Il1403 4-oxalocrotonate tautomerase NP_266730.1 568265 R 272623 CDS NP_266731.1 15672557 1114195 568648..570975 1 NC_002662.1 transort and binding protein, cations; cation-transporting ATPase 570975 yfgQ 1114195 yfgQ Lactococcus lactis subsp. lactis Il1403 cation-transporting ATPase NP_266731.1 568648 D 272623 CDS NP_266732.1 15672558 1114196 570988..571431 1 NC_002662.1 paralogous to yafE; hypothetical protein 571431 yfhA 1114196 yfhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266732.1 570988 D 272623 CDS NP_266733.1 15672559 1114197 571538..572470 1 NC_002662.1 hypothetical protein 572470 yfhB 1114197 yfhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266733.1 571538 D 272623 CDS NP_266734.1 15672560 1114198 572714..573307 1 NC_002662.1 hypothetical protein 573307 yfhC 1114198 yfhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266734.1 572714 D 272623 CDS NP_266735.1 15672561 1114199 573505..573987 1 NC_002662.1 carotenoid biosynthetic protein CrtK 573987 crtK 1114199 crtK Lactococcus lactis subsp. lactis Il1403 carotenoid biosynthetic protein CrtK NP_266735.1 573505 D 272623 CDS NP_266736.1 15672562 1114200 574106..574507 1 NC_002662.1 hypothetical protein 574507 yfhF 1114200 yfhF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266736.1 574106 D 272623 CDS NP_266737.1 15672563 1114201 574511..576307 1 NC_002662.1 hypothetical protein 576307 yfhG 1114201 yfhG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266737.1 574511 D 272623 CDS NP_266738.1 15672564 1114202 576304..577077 1 NC_002662.1 hypothetical protein 577077 yfhH 1114202 yfhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266738.1 576304 D 272623 CDS NP_266739.1 15672565 1114203 577224..577586 1 NC_002662.1 hypothetical protein 577586 yfhI 1114203 yfhI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266739.1 577224 D 272623 CDS NP_266740.1 15672566 1114204 577706..578074 1 NC_002662.1 hypothetical protein 578074 yfhJ 1114204 yfhJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266740.1 577706 D 272623 CDS NP_266741.1 15672567 1114205 578303..578587 1 NC_002662.1 hypothetical protein 578587 yfhK 1114205 yfhK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266741.1 578303 D 272623 CDS NP_266742.1 15672568 1114206 complement(578890..579588) 1 NC_002662.1 hypothetical protein 579588 yfhL 1114206 yfhL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266742.1 578890 R 272623 CDS NP_266743.1 15672569 1114207 complement(579746..580126) 1 NC_002662.1 hypothetical protein 580126 yfiA 1114207 yfiA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266743.1 579746 R 272623 CDS NP_266744.1 15672570 1114208 complement(580086..581552) 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; evidence experimental PMID:9097419; involved in UV protection and mutagenesis; may modify DNA replication machinery to allow bypass through a damaged template; UmuC 581552 umuC 1114208 umuC Lactococcus lactis subsp. lactis Il1403 UmuC NP_266744.1 580086 R 272623 CDS NP_266745.1 15672571 1114209 complement(582008..582541) 1 NC_002662.1 hypothetical protein 582541 yfiC 1114209 yfiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266745.1 582008 R 272623 CDS NP_266746.1 15672572 1114210 582842..583351 1 NC_002662.1 hypothetical protein 583351 yfiD 1114210 yfiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266746.1 582842 D 272623 CDS NP_266747.1 15672573 1114211 complement(583404..583835) 1 NC_002662.1 MarR-family regulators; transcriptional regulator 583835 rmaJ 1114211 rmaJ Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266747.1 583404 R 272623 CDS NP_266748.1 15672574 1114212 583936..584349 1 NC_002662.1 hypothetical protein 584349 yfiE 1114212 yfiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266748.1 583936 D 272623 CDS NP_266749.1 15672575 1114213 584876..585445 1 NC_002662.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 585445 yfiG 1114213 yfiG Lactococcus lactis subsp. lactis Il1403 thymidine kinase NP_266749.1 584876 D 272623 CDS NP_266750.1 15672576 1114214 585501..585944 1 NC_002662.1 hypothetical protein 585944 yfiH 1114214 yfiH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266750.1 585501 D 272623 CDS NP_266751.1 15672577 1114215 585962..587035 1 NC_002662.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 587035 prfA 1114215 prfA Lactococcus lactis subsp. lactis Il1403 peptide chain release factor 1 NP_266751.1 585962 D 272623 CDS NP_266752.1 15672578 1114216 587035..587562 1 NC_002662.1 hypothetical protein 587562 yfiI 1114216 yfiI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266752.1 587035 D 272623 CDS NP_266753.1 15672579 1114217 587730..588380 1 NC_002662.1 electron transport; NADPH-flavin oxidoreductase 588380 yfiJ 1114217 yfiJ Lactococcus lactis subsp. lactis Il1403 NADPH-flavin oxidoreductase NP_266753.1 587730 D 272623 CDS NP_266754.1 15672580 1114218 588486..589298 1 NC_002662.1 heme and porphyrin; may be involved in the oxidation of protoporphyrinogen into protoporphyrin IX; protoporphyrinogen oxidase 589298 hemK 1114218 hemK Lactococcus lactis subsp. lactis Il1403 protoporphyrinogen oxidase NP_266754.1 588486 D 272623 CDS NP_266755.1 15672581 1114219 589332..589796 1 NC_002662.1 probably an acetyltransferase; hypothetical protein 589796 yfiL 1114219 yfiL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266755.1 589332 D 272623 CDS NP_266756.1 15672582 1114220 589901..590713 1 NC_002662.1 hypothetical protein 590713 yfjA 1114220 yfjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266756.1 589901 D 272623 CDS NP_266757.1 15672583 1114221 590943..592190 1 NC_002662.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 592190 glyA 1114221 glyA Lactococcus lactis subsp. lactis Il1403 serine hydroxymethyltransferase NP_266757.1 590943 D 272623 CDS NP_266758.1 15672584 1114222 592351..592953 1 NC_002662.1 transposon related function; similar to Orf14 of Enterococcus faecalis transposon Tn916; transposon-related protein 592953 yfjB 1114222 yfjB Lactococcus lactis subsp. lactis Il1403 transposon-related protein NP_266758.1 592351 D 272623 CDS NP_266759.1 15672585 1114223 593080..594177 1 NC_002662.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 594177 serC 1114223 serC Lactococcus lactis subsp. lactis Il1403 phosphoserine aminotransferase NP_266759.1 593080 D 272623 CDS NP_266760.1 15672586 1114224 594174..595370 1 NC_002662.1 serine family; similar to N-terminal part of SerA; D-3-phosphoglycerate dehydrogenase 595370 serA 1114224 serA Lactococcus lactis subsp. lactis Il1403 D-3-phosphoglycerate dehydrogenase NP_266760.1 594174 D 272623 CDS NP_266761.1 15672587 1114225 595394..596044 1 NC_002662.1 serine family; phosphoserine phosphatase 596044 serB 1114225 serB Lactococcus lactis subsp. lactis Il1403 phosphoserine phosphatase NP_266761.1 595394 D 272623 CDS NP_266762.1 15672588 1114226 complement(596163..596456) 1 NC_002662.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 596456 yfjC 1114226 yfjC Lactococcus lactis subsp. lactis Il1403 acylphosphatase NP_266762.1 596163 R 272623 CDS NP_266763.1 15672589 1114227 596779..597537 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; tRNA/rRNA methyltransferase 597537 yfjD 1114227 yfjD Lactococcus lactis subsp. lactis Il1403 tRNA/rRNA methyltransferase NP_266763.1 596779 D 272623 CDS NP_266764.2 30024002 1114228 complement(597682..598125) 1 NC_002662.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 598125 yfjE 1114228 yfjE Lactococcus lactis subsp. lactis Il1403 flavodoxin NP_266764.2 597682 R 272623 CDS NP_266765.1 15672591 1114229 complement(598274..599779) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to many multidrug resistance transporters; membrane-bound transport protein 599779 yfjF 1114229 yfjF Lactococcus lactis subsp. lactis Il1403 membrane-bound transport protein NP_266765.1 598274 R 272623 CDS NP_266768.1 15672594 1114232 600904..601758 1 NC_002662.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 601758 pepM 1114232 pepM Lactococcus lactis subsp. lactis Il1403 methionine aminopeptidase NP_266768.1 600904 D 272623 CDS NP_266769.1 15672595 1114233 601790..602683 1 NC_002662.1 probably tRNA-processing ribonuclease; similar to ribonuclease BN; evidenced by COGnitor; hypothetical protein 602683 ygaB 1114233 ygaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266769.1 601790 D 272623 CDS NP_266770.1 15672596 1114234 complement(602814..603260) 1 NC_002662.1 hypothetical protein 603260 ygaC 1114234 ygaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266770.1 602814 R 272623 CDS NP_266771.1 15672597 1114235 603398..604129 1 NC_002662.1 hypothetical protein 604129 ygaD 1114235 ygaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266771.1 603398 D 272623 CDS NP_266772.1 15672598 1114236 604161..604436 1 NC_002662.1 hypothetical protein 604436 ygaE 1114236 ygaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266772.1 604161 D 272623 CDS NP_266773.1 15672599 1114237 604542..604718 1 NC_002662.1 hypothetical protein 604718 ygaF 1114237 ygaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266773.1 604542 D 272623 CDS NP_266774.1 15672600 1114238 604822..605751 1 NC_002662.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 605751 ptsK 1114238 ptsK Lactococcus lactis subsp. lactis Il1403 HPr kinase/phosphorylase NP_266774.1 604822 D 272623 CDS NP_266775.1 15672601 1114239 605815..606600 1 NC_002662.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 606600 lgt 1114239 lgt Lactococcus lactis subsp. lactis Il1403 prolipoprotein diacylglyceryl transferase NP_266775.1 605815 D 272623 CDS NP_266776.1 15672602 1114240 606768..607187 1 NC_002662.1 similar to a tropomyosin-related protein STRP from Saccharomyces cerevisiae; hypothetical protein 607187 ygaI 1114240 ygaI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266776.1 606768 D 272623 CDS NP_266777.1 15672603 1114241 607217..607780 1 NC_002662.1 hypothetical protein 607780 ygaJ 1114241 ygaJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266777.1 607217 D 272623 CDS NP_266778.1 15672604 1114242 607913..609331 1 NC_002662.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 609331 gnd 1114242 gnd Lactococcus lactis subsp. lactis Il1403 6-phosphogluconate dehydrogenase NP_266778.1 607913 D 272623 CDS NP_266779.1 15672605 1114243 609512..611524 1 NC_002662.1 transort and binding protein, cations; potassium uptake protein 611524 kupA 1114243 kupA Lactococcus lactis subsp. lactis Il1403 potassium uptake protein NP_266779.1 609512 D 272623 CDS NP_266780.1 15672606 1114244 611749..613764 1 NC_002662.1 transort and binding protein, cations; potassium uptake protein 613764 kupB 1114244 kupB Lactococcus lactis subsp. lactis Il1403 potassium uptake protein NP_266780.1 611749 D 272623 CDS NP_266781.1 15672607 1114245 614196..614861 1 NC_002662.1 similar to YqfU of Bacillus subtilis; hypothetical protein 614861 ygbB 1114245 ygbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266781.1 614196 D 272623 CDS NP_266782.1 15672608 1114246 614999..615883 1 NC_002662.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 615883 miaA 1114246 miaA Lactococcus lactis subsp. lactis Il1403 tRNA delta(2)-isopentenylpyrophosphate transferase NP_266782.1 614999 D 272623 CDS NP_266783.1 15672609 1114247 615966..616634 1 NC_002662.1 hypothetical protein 616634 ygbD 1114247 ygbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266783.1 615966 D 272623 CDS NP_266784.1 15672610 1114248 616805..617701 1 NC_002662.1 probably membrane protease subunit; evidenced by COGnitor; hypothetical protein 617701 ygbE 1114248 ygbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266784.1 616805 D 272623 CDS NP_266785.1 15672611 1114249 618076..618336 1 NC_002662.1 hypothetical protein 618336 ygbF 1114249 ygbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266785.1 618076 D 272623 CDS NP_266786.1 15672612 1114250 618694..619617 1 NC_002662.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 619617 ygbG 1114250 ygbG Lactococcus lactis subsp. lactis Il1403 ribonuclease Z NP_266786.1 618694 D 272623 CDS NP_266787.1 15672613 1114251 619610..620311 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 620311 ygcA 1114251 ygcA Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266787.1 619610 D 272623 CDS NP_266788.1 15672614 1114252 620478..622706 1 NC_002662.1 ssDNA-specific exonuclease RecJ 622706 recJ 1114252 recJ Lactococcus lactis subsp. lactis Il1403 ssDNA-specific exonuclease RecJ NP_266788.1 620478 D 272623 CDS NP_266789.1 15672615 1114253 622784..623341 1 NC_002662.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 623341 apt 1114253 apt Lactococcus lactis subsp. lactis Il1403 adenine phosphoribosyltransferase NP_266789.1 622784 D 272623 CDS NP_266790.1 15672616 1114254 623557..624120 1 NC_002662.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 624120 rpoE 1114254 rpoE Lactococcus lactis subsp. lactis Il1403 DNA-directed RNA polymerase subunit delta NP_266790.1 623557 D 272623 CDS NP_266791.1 15672617 1114255 624257..625909 1 NC_002662.1 similar to YrrL of Bacillus subtilis; hypothetical protein 625909 ygcC 1114255 ygcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266791.1 624257 D 272623 CDS NP_266792.1 15672618 1114256 625972..626442 1 NC_002662.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 626442 greA 1114256 greA Lactococcus lactis subsp. lactis Il1403 transcription elongation factor GreA NP_266792.1 625972 D 272623 CDS NP_266793.1 15672619 1114257 complement(626561..627322) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase; transposase of IS904E 627322 tra904E 1114257 tra904E Lactococcus lactis subsp. lactis Il1403 transposase of IS904E NP_266793.1 626561 R 272623 CDS NP_266794.1 15672620 1114258 complement(627418..627708) 1 NC_002662.1 transposon related function; hypothetical protein 627708 ygcD 1114258 ygcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266794.1 627418 R 272623 CDS NP_266795.1 15672621 1114259 complement(627782..628465) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase; IS1077D transposase 628465 tra1077D 1114259 tra1077D Lactococcus lactis subsp. lactis Il1403 IS1077D transposase NP_266795.1 627782 R 272623 CDS NP_266796.1 15672622 1114260 complement(628597..629154) 1 NC_002662.1 transposon related function; hypothetical protein 629154 ygcE 1114260 ygcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266796.1 628597 R 272623 CDS NP_266797.1 15672623 1114261 629354..629809 1 NC_002662.1 transctiptional regulator; adaptations and atypical conditions; regulator of class III stress genes (clpC, clpP); hypothetical protein 629809 ctsR 1114261 ctsR Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266797.1 629354 D 272623 CDS NP_266798.1 15672624 1114262 629799..632249 1 NC_002662.1 evidence experimental PMID:10094684; adaptations and atypical conditions; CLPC subfamily; ATP-dependent protease ATP-binding subunit 632249 clpC 1114262 clpC Lactococcus lactis subsp. lactis Il1403 ATP-dependent protease ATP-binding subunit NP_266798.1 629799 D 272623 CDS NP_266799.1 15672625 1114263 632384..632941 1 NC_002662.1 hypothetical protein 632941 ygdA 1114263 ygdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266799.1 632384 D 272623 CDS NP_266800.1 15672626 1114264 633126..634427 1 NC_002662.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 634427 eno 1114264 eno Lactococcus lactis subsp. lactis Il1403 phosphopyruvate hydratase NP_266800.1 633126 D 272623 CDS NP_266801.1 15672627 1114265 634512..635450 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; integrase-recombinase 635450 xerD 1114265 xerD Lactococcus lactis subsp. lactis Il1403 integrase-recombinase NP_266801.1 634512 D 272623 CDS NP_266802.1 15672628 1114266 635723..636490 1 NC_002662.1 hypothetical protein 636490 ygdC 1114266 ygdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266802.1 635723 D 272623 CDS NP_266803.1 15672629 1114267 637078..637218 1 NC_002662.1 hypothetical protein 637218 ygdD 1114267 ygdD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266803.1 637078 D 272623 CDS NP_266804.1 15672630 1114268 637534..637716 1 NC_002662.1 hypothetical protein 637716 ygdF 1114268 ygdF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266804.1 637534 D 272623 CDS NP_266805.1 15672631 1114269 637738..638907 1 NC_002662.1 hypothetical protein 638907 ygdE 1114269 ygdE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266805.1 637738 D 272623 CDS NP_266806.1 15672632 1114271 640780..643767 1 NC_002662.1 type I restriction enzyme R protein 643767 hsdR 1114271 hsdR Lactococcus lactis subsp. lactis Il1403 type I restriction enzyme R protein NP_266806.1 640780 D 272623 CDS NP_266807.1 15672633 1114272 643807..645354 1 NC_002662.1 type I restriction enzyme M protein 645354 hsdM 1114272 hsdM Lactococcus lactis subsp. lactis Il1403 type I restriction enzyme M protein NP_266807.1 643807 D 272623 CDS NP_266808.1 15672634 1114273 645351..646574 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; evidence experimental PMID:9593305; subunit S dictates DNA sequence specificity; type I restriction enzyme specificity protein 646574 hsdS 1114273 hsdS Lactococcus lactis subsp. lactis Il1403 type I restriction enzyme specificity protein NP_266808.1 645351 D 272623 CDS NP_835298.1 30024003 1114274 646595..646720 1 NC_002662.1 hypothetical protein 646720 1114274 L200023 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835298.1 646595 D 272623 CDS NP_266809.1 15672635 1114275 646698..647777 1 NC_002662.1 hypothetical protein 647777 ygeA 1114275 ygeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266809.1 646698 D 272623 CDS NP_266810.1 15672636 1114276 647939..648208 1 NC_002662.1 hypothetical protein 648208 ygeB 1114276 ygeB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266810.1 647939 D 272623 CDS NP_266811.1 15672637 1114277 648543..648710 1 NC_002662.1 hypothetical protein 648710 ygeC 1114277 ygeC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266811.1 648543 D 272623 CDS NP_266812.1 15672638 1114278 648976..649746 1 NC_002662.1 hypothetical protein 649746 ygeD 1114278 ygeD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266812.1 648976 D 272623 CDS NP_266813.1 15672639 1114279 complement(650157..650996) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function. related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981C 650996 tra981C 1114279 tra981C Lactococcus lactis subsp. lactis Il1403 transposase of IS981C NP_266813.1 650157 R 272623 CDS NP_266814.1 15672640 1114280 complement(651008..651175) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 651175 ygfF 1114280 ygfF Lactococcus lactis subsp. lactis Il1403 transposase NP_266814.1 651008 R 272623 CDS NP_835299.1 30024004 1114281 651422..651511 1 NC_002662.1 hypothetical protein 651511 1114281 L200024 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835299.1 651422 D 272623 CDS NP_835300.1 30024005 1114282 651800..651895 1 NC_002662.1 hypothetical protein 651895 1114282 L200025 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835300.1 651800 D 272623 CDS NP_266815.1 15672641 1114283 complement(652010..652681) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 652681 ygfA 1114283 ygfA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_266815.1 652010 R 272623 CDS NP_266816.1 15672642 1114284 complement(652684..653757) 1 NC_002662.1 transport and binding protein; ABC transporter permease 653757 ygfB 1114284 ygfB Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_266816.1 652684 R 272623 CDS NP_266817.1 15672643 1114285 complement(653769..654338) 1 NC_002662.1 TetR/AcrR family of transcription regulators; transcriptional regulator 654338 ygfC 1114285 ygfC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266817.1 653769 R 272623 CDS NP_266818.1 15672644 1114286 complement(654526..656049) 1 NC_002662.1 fatty acid and phospholipid metabolism; long-chain acyl-CoA synthetase 656049 fadD 1114286 fadD Lactococcus lactis subsp. lactis Il1403 long-chain acyl-CoA synthetase NP_266818.1 654526 R 272623 CDS NP_266819.1 15672645 1114287 656294..657157 1 NC_002662.1 transort and binding protein; cations; divalent cation transport-related protein 657157 ygfE 1114287 ygfE Lactococcus lactis subsp. lactis Il1403 divalent cation transport-related protein NP_266819.1 656294 D 272623 CDS NP_266820.1 15672646 1114288 657418..659781 1 NC_002662.1 evidence experimental PMID:9294449; energy metabolism; fermentation; pyruvate-formate lyase 659781 pfl 1114288 pfl Lactococcus lactis subsp. lactis Il1403 pyruvate-formate lyase NP_266820.1 657418 D 272623 CDS NP_266821.1 15672647 1114289 659913..660572 1 NC_002662.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 660572 coaE 1114289 coaE Lactococcus lactis subsp. lactis Il1403 dephospho-CoA kinase NP_266821.1 659913 D 272623 CDS NP_266822.1 15672648 1114290 660575..661792 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to PmrA of Streptococcus pneumoniae; multidrug resistance efflux pump 661792 pmrA 1114290 pmrA Lactococcus lactis subsp. lactis Il1403 multidrug resistance efflux pump NP_266822.1 660575 D 272623 CDS NP_266823.1 15672649 1114291 661789..661935 1 NC_002662.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 661935 rpmG 1114291 rpmG Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L33 NP_266823.1 661789 D 272623 CDS NP_266824.1 15672650 1114292 662276..663538 1 NC_002662.1 cell division protein; similar to cell division protein FtsW of Enterococcus hirae; FtsW1 663538 ftsW1 1114292 ftsW1 Lactococcus lactis subsp. lactis Il1403 FtsW1 NP_266824.1 662276 D 272623 CDS NP_266825.1 15672651 1114293 663644..667057 1 NC_002662.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 667057 pycA 1114293 pycA Lactococcus lactis subsp. lactis Il1403 pyruvate carboxylase NP_266825.1 663644 D 272623 CDS NP_266826.2 161723238 1114294 667208..668506 1 NC_002662.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 668506 gltA 1114294 gltA Lactococcus lactis subsp. lactis Il1403 citrate synthase NP_266826.2 667208 D 272623 CDS NP_266827.1 15672653 1114295 668503..671049 1 NC_002662.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 671049 citB 1114295 citB Lactococcus lactis subsp. lactis Il1403 aconitate hydratase NP_266827.1 668503 D 272623 CDS NP_266828.1 15672654 1114296 671070..672308 1 NC_002662.1 TCA cycle; glutamate synthesis; isocitrate dehydrogenase 672308 icd 1114296 icd Lactococcus lactis subsp. lactis Il1403 isocitrate dehydrogenase NP_266828.1 671070 D 272623 CDS NP_266829.1 15672655 1114297 complement(672374..672973) 1 NC_002662.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 672973 clpP 1114297 clpP Lactococcus lactis subsp. lactis Il1403 ATP-dependent Clp protease proteolytic subunit NP_266829.1 672374 R 272623 CDS NP_266830.1 15672656 1114298 673194..673700 1 NC_002662.1 hypothetical protein 673700 yghB 1114298 yghB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266830.1 673194 D 272623 CDS NP_266831.1 15672657 1114299 673860..674258 1 NC_002662.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 674258 spxA 1114299 spxA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator Spx NP_266831.1 673860 D 272623 CDS NP_266832.1 15672658 1114300 complement(674640..675608) 1 NC_002662.1 hypothetical protein 675608 yghD 1114300 yghD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266832.1 674640 R 272623 CDS NP_266833.1 15672659 1114301 complement(675656..675853) 1 NC_002662.1 hypothetical protein 675853 yghE 1114301 yghE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266833.1 675656 R 272623 CDS NP_266834.1 15672660 1114302 676147..678903 1 NC_002662.1 transort and binding protein, cations; cation-transporting ATPase 678903 pacL 1114302 pacL Lactococcus lactis subsp. lactis Il1403 cation-transporting ATPase NP_266834.1 676147 D 272623 CDS NP_266835.1 15672661 1114303 679391..680422 1 NC_002662.1 hypothetical protein 680422 yghG 1114303 yghG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266835.1 679391 D 272623 CDS NP_266836.1 15672662 1114304 680427..681491 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaA of Staphylococcus epidermidis; glycosyl transferase family protein 681491 icaA 1114304 icaA Lactococcus lactis subsp. lactis Il1403 glycosyl transferase family protein NP_266836.1 680427 D 272623 CDS NP_266837.1 15672663 1114305 681575..682522 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983A 682522 tra983A 1114305 tra983A Lactococcus lactis subsp. lactis Il1403 transposase of IS983A NP_266837.1 681575 D 272623 CDS NP_266838.1 15672664 1114306 682537..683367 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaB of Staphylococcus epidermidis; intercellular adhesion protein 683367 icaB 1114306 icaB Lactococcus lactis subsp. lactis Il1403 intercellular adhesion protein NP_266838.1 682537 D 272623 CDS NP_266839.1 15672665 1114307 683394..683639 1 NC_002662.1 similar to peptidoglycan bound protein; hypothetical protein 683639 ygiC 1114307 ygiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266839.1 683394 D 272623 CDS NP_266840.1 15672666 1114308 683636..684646 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; mediates attachement of cells to collagen containing substrates; collagen adhesin 684646 icaC 1114308 icaC Lactococcus lactis subsp. lactis Il1403 collagen adhesin NP_266840.1 683636 D 272623 CDS NP_266841.1 15672667 1114310 complement(686532..686849) 1 NC_002662.1 probably ATPase with chaperone activity, ATP-binding domain, evidenced by COGnitor; hypothetical protein 686849 ygiG 1114310 ygiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266841.1 686532 R 272623 CDS NP_266842.1 15672668 1114311 complement(686804..687118) 1 NC_002662.1 hypothetical protein 687118 ygiH 1114311 ygiH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266842.1 686804 R 272623 CDS NP_266843.1 15672669 1114312 687395..688168 1 NC_002662.1 hydrolase of PHP superfamily; hypothetical protein 688168 ygiI 1114312 ygiI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266843.1 687395 D 272623 CDS NP_266844.1 15672670 1114313 688206..688739 1 NC_002662.1 similar to Listeria monocytogenes FlaR; hypothetical protein 688739 ygiJ 1114313 ygiJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266844.1 688206 D 272623 CDS NP_266845.1 15672671 1114314 688717..689337 1 NC_002662.1 hypothetical protein 689337 ygiK 1114314 ygiK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266845.1 688717 D 272623 CDS NP_266846.1 15672672 1114315 689448..690332 1 NC_002662.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 690332 ksgA 1114315 ksgA Lactococcus lactis subsp. lactis Il1403 dimethyladenosine transferase NP_266846.1 689448 D 272623 CDS NP_266847.1 15672673 1114316 690433..691491 1 NC_002662.1 evidence experimental PMID:9797327; degradation of proteins, peptides, and glycopeptides; aminopeptidase P 691491 pepP 1114316 pepP Lactococcus lactis subsp. lactis Il1403 aminopeptidase P NP_266847.1 690433 D 272623 CDS NP_266848.1 15672674 1114317 691623..692180 1 NC_002662.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 692180 efp 1114317 efp Lactococcus lactis subsp. lactis Il1403 elongation factor P NP_266848.1 691623 D 272623 CDS NP_266849.1 15672675 1114318 692276..692728 1 NC_002662.1 hypothetical protein 692728 ygjB 1114318 ygjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266849.1 692276 D 272623 CDS NP_266850.1 15672676 1114319 692721..693692 1 NC_002662.1 transcription termination protein; RNA synthesis, modification, and DNA transcription; hypothetical protein 693692 nusB 1114319 nusB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266850.1 692721 D 272623 CDS NP_266853.1 15672679 1114322 696013..697155 1 NC_002662.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 697155 glgC 1114322 glgC Lactococcus lactis subsp. lactis Il1403 glucose-1-phosphate adenylyltransferase NP_266853.1 696013 D 272623 CDS NP_266854.1 15672680 1114323 697145..698284 1 NC_002662.1 central intermediary metabolism; subunit of ADP-glucose pyrophosphorylase; glucose-1-phosphate adenylyltransferase 698284 glgD 1114323 glgD Lactococcus lactis subsp. lactis Il1403 glucose-1-phosphate adenylyltransferase NP_266854.1 697145 D 272623 CDS NP_266855.1 15672681 1114324 698361..699812 1 NC_002662.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 699812 glgA 1114324 glgA Lactococcus lactis subsp. lactis Il1403 glycogen synthase NP_266855.1 698361 D 272623 CDS NP_266856.1 15672682 1114325 699901..702303 1 NC_002662.1 central intermediary metabolism; glycogen phosphorylase 702303 glgP 1114325 glgP Lactococcus lactis subsp. lactis Il1403 glycogen phosphorylase NP_266856.1 699901 D 272623 CDS NP_266857.1 15672683 1114326 702393..704195 1 NC_002662.1 degradation of polysaccharides; amylopullulanase 704195 apu 1114326 apu Lactococcus lactis subsp. lactis Il1403 amylopullulanase NP_266857.1 702393 D 272623 CDS NP_266858.1 15672684 1114327 704421..705914 1 NC_002662.1 evidence experimental PMID:8157671; transport and binding protein; amino acids, peptides and amines; di-/tripeptide transporter 705914 dtpT 1114327 dtpT Lactococcus lactis subsp. lactis Il1403 di-/tripeptide transporter NP_266858.1 704421 D 272623 CDS NP_266859.1 15672685 1114328 706695..707642 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983B 707642 tra983B 1114328 tra983B Lactococcus lactis subsp. lactis Il1403 transposase of IS983B NP_266859.1 706695 D 272623 CDS NP_266860.1 15672686 1114329 707710..709185 1 NC_002662.1 energy metabolism; electron transport; cytochrome D ubiquinol oxidase subunit I 709185 cydA 1114329 cydA Lactococcus lactis subsp. lactis Il1403 cytochrome D ubiquinol oxidase subunit I NP_266860.1 707710 D 272623 CDS NP_266861.1 15672687 1114330 709185..710180 1 NC_002662.1 energy metabolism; electron transport; cytochrome D ubiquinol oxidase subunit II 710180 cydB 1114330 cydB Lactococcus lactis subsp. lactis Il1403 cytochrome D ubiquinol oxidase subunit II NP_266861.1 709185 D 272623 CDS NP_266862.2 30024006 1114331 710487..712376 1 NC_002662.1 transport and binding protein; multidrug resistance; involved in the cytochrome D branch of aerobic respiration; MDR subfamily; cytochrome D ABC transporter ATP-binding protein/permease 712376 cydC 1114331 cydC Lactococcus lactis subsp. lactis Il1403 cytochrome D ABC transporter ATP-binding protein/permease NP_266862.2 710487 D 272623 CDS NP_266863.1 15672689 1114332 712348..714069 1 NC_002662.1 transport and binding protein; multidrug resistance; involved in the cytochrome D branch of aerobic respiration; MDR subfamily; cytochrome D ABC transporter ATP-binding protein/permease 714069 cydD 1114332 cydD Lactococcus lactis subsp. lactis Il1403 cytochrome D ABC transporter ATP-binding protein/permease NP_266863.1 712348 D 272623 CDS NP_266864.1 15672690 1114333 714363..715238 1 NC_002662.1 MarR-family regulators; belongs to the MarR family; transcriptional regulator 715238 rmaB 1114333 rmaB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266864.1 714363 D 272623 CDS NP_266865.1 15672691 1114334 715264..715752 1 NC_002662.1 hypothetical protein 715752 yhbE 1114334 yhbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266865.1 715264 D 272623 CDS NP_266866.1 15672692 1114335 715779..716453 1 NC_002662.1 similar to several proteins from eukaryotes; hypothetical protein 716453 yhbF 1114335 yhbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266866.1 715779 D 272623 CDS NP_266867.1 15672693 1114336 716555..718309 1 NC_002662.1 evidence experimental PMID:8855237; transport and binding protein; multidrug resistance; multidrug resistance ABC transporter ATP-binding protein/permease 718309 lmrA 1114336 lmrA Lactococcus lactis subsp. lactis Il1403 multidrug resistance ABC transporter ATP-binding protein/permease NP_266867.1 716555 D 272623 CDS NP_266868.1 15672694 1114337 complement(718328..718939) 1 NC_002662.1 hypothetical protein 718939 yhbH 1114337 yhbH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266868.1 718328 R 272623 CDS NP_266869.1 15672695 1114338 complement(719010..719654) 1 NC_002662.1 phosphorus compounds; complements a phoA mutation in Escherichia coli; alkaline phosphatase 719654 apl 1114338 apl Lactococcus lactis subsp. lactis Il1403 alkaline phosphatase NP_266869.1 719010 R 272623 CDS NP_266870.1 15672696 1114339 complement(719869..721863) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 721863 yhcA 1114339 yhcA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_266870.1 719869 R 272623 CDS NP_266871.1 15672697 1114340 complement(721971..722189) 1 NC_002662.1 similar to hypothetical protein MJ1230 of Methanococcus jannaschii; hypothetical protein 722189 yhcC 1114340 yhcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266871.1 721971 R 272623 CDS NP_266872.1 15672698 1114341 722399..723061 1 NC_002662.1 hypothetical protein 723061 yhcB 1114341 yhcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266872.1 722399 D 272623 CDS NP_266873.1 15672699 1114342 complement(723093..724079) 1 NC_002662.1 energy metabolism; electron transport; quinone oxidoreductase 724079 qor 1114342 qor Lactococcus lactis subsp. lactis Il1403 quinone oxidoreductase NP_266873.1 723093 R 272623 CDS NP_266874.1 15672700 1114343 724247..725356 1 NC_002662.1 probably methionine synthase II, evidenced by COGnitor; hypothetical protein 725356 yhcE 1114343 yhcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266874.1 724247 D 272623 CDS NP_266875.1 15672701 1114344 725482..726234 1 NC_002662.1 probably metal-dependent hydrolase, evidenced by COGnitor; hypothetical protein 726234 yhcG 1114344 yhcG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266875.1 725482 D 272623 CDS NP_266876.1 15672702 1114345 726222..727160 1 NC_002662.1 probably protein phosphatase, evidenced by COGnitor; hypothetical protein 727160 yhcH 1114345 yhcH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266876.1 726222 D 272623 CDS NP_266877.1 15672703 1114346 727161..727628 1 NC_002662.1 probably amino acid deaminase, evidenced by COGnitor; hypothetical protein 727628 yhcI 1114346 yhcI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266877.1 727161 D 272623 CDS NP_266878.1 15672704 1114347 complement(728130..728969) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function. related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981D 728969 tra981D 1114347 tra981D Lactococcus lactis subsp. lactis Il1403 transposase of IS981D NP_266878.1 728130 R 272623 CDS NP_266879.1 15672705 1114348 complement(728981..729241) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 729241 yhcJ 1114348 yhcJ Lactococcus lactis subsp. lactis Il1403 transposase NP_266879.1 728981 R 272623 CDS NP_835301.1 30024007 1114349 729346..729459 1 NC_002662.1 hypothetical protein 729459 1114349 L200027 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835301.1 729346 D 272623 CDS NP_266880.1 15672706 1114350 729487..730284 1 NC_002662.1 similar to C-terminal parts of alpha-glucosidases from differenr species; hypothetical protein 730284 yhcK 1114350 yhcK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266880.1 729487 D 272623 CDS NP_266881.1 15672707 1114351 730327..731367 1 NC_002662.1 LacI-family regulators; LacI family transcriptional regulator 731367 rliC 1114351 rliC Lactococcus lactis subsp. lactis Il1403 LacI family transcriptional regulator NP_266881.1 730327 D 272623 CDS NP_266882.1 15672708 1114352 complement(731368..731784) 1 NC_002662.1 similar to ComAB (YuxO) protein of Bacillus subtilis; hypothetical protein 731784 yhdA 1114352 yhdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266882.1 731368 R 272623 CDS NP_266883.1 15672709 1114353 complement(731781..732884) 1 NC_002662.1 menaquinone and ubiquinone; probably involved in menaquinone biosynthesis; racemase 732884 yhdB 1114353 yhdB Lactococcus lactis subsp. lactis Il1403 racemase NP_266883.1 731781 R 272623 CDS NP_266884.2 30024008 1114354 complement(732881..734236) 1 NC_002662.1 menaquinone and ubiquinone; O-succinylbenzoic acid--CoA ligase 734236 menE 1114354 menE Lactococcus lactis subsp. lactis Il1403 O-succinylbenzoic acid--CoA ligase NP_266884.2 732881 R 272623 CDS NP_266885.1 15672711 1114355 complement(734363..735205) 1 NC_002662.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 735205 menB 1114355 menB Lactococcus lactis subsp. lactis Il1403 naphthoate synthase NP_266885.1 734363 R 272623 CDS NP_266886.1 15672712 1114356 complement(735592..736407) 1 NC_002662.1 menaquinone and ubiquinone; counterpart of Bacillus subtilis YtxM; YtxM-like protein 736407 menX 1114356 menX Lactococcus lactis subsp. lactis Il1403 YtxM-like protein NP_266886.1 735592 R 272623 CDS NP_266887.1 15672713 1114357 complement(736397..738079) 1 NC_002662.1 menaquinone and ubiquinone; 2-oxoglutarate decarboxylase 738079 menD 1114357 menD Lactococcus lactis subsp. lactis Il1403 2-oxoglutarate decarboxylase NP_266887.1 736397 R 272623 CDS NP_266888.1 15672714 1114358 complement(738133..739347) 1 NC_002662.1 menaquinone and ubiquinone; menaquinone-specific isochorismate synthase 739347 menF 1114358 menF Lactococcus lactis subsp. lactis Il1403 menaquinone-specific isochorismate synthase NP_266888.1 738133 R 272623 CDS NP_266889.1 15672715 1114359 739685..740266 1 NC_002662.1 ribosomal proteins: synthesis and modification; acetyl transferase 740266 yhdC 1114359 yhdC Lactococcus lactis subsp. lactis Il1403 acetyl transferase NP_266889.1 739685 D 272623 CDS NP_266890.1 15672716 1114360 740273..741553 1 NC_002662.1 similar to YtoI of Bacillus subtilis; hypothetical protein 741553 yheA 1114360 yheA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266890.1 740273 D 272623 CDS NP_266891.1 15672717 1114361 741571..742494 1 NC_002662.1 similar to YtqI of Bacillus subtilis; hypothetical protein 742494 yheB 1114361 yheB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266891.1 741571 D 272623 CDS NP_266892.1 15672718 1114362 complement(742698..743669) 1 NC_002662.1 energy metabolism, amino acids and amines; L-asparaginase 743669 ansB 1114362 ansB Lactococcus lactis subsp. lactis Il1403 L-asparaginase NP_266892.1 742698 R 272623 CDS NP_266893.1 15672719 1114363 743861..745249 1 NC_002662.1 hypothetical protein 745249 yheD 1114363 yheD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266893.1 743861 D 272623 CDS NP_266894.1 15672720 1114364 745339..745683 1 NC_002662.1 hypothetical protein 745683 yheE 1114364 yheE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266894.1 745339 D 272623 CDS NP_266895.1 15672721 1114365 745742..747253 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to flotillin; flotillin-like protein 747253 floL 1114365 floL Lactococcus lactis subsp. lactis Il1403 flotillin-like protein NP_266895.1 745742 D 272623 CDS NP_266896.1 15672722 1114366 complement(747291..748643) 1 NC_002662.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 748643 thrA 1114366 thrA Lactococcus lactis subsp. lactis Il1403 aspartate kinase NP_266896.1 747291 R 272623 CDS NP_266897.1 15672723 1114367 complement(748873..749739) 1 NC_002662.1 probably phosphoesterase, evidenced by COGnitor; hypothetical protein 749739 yheG 1114367 yheG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266897.1 748873 R 272623 CDS NP_266898.1 15672724 1114368 complement(749729..750205) 1 NC_002662.1 MarR-family regulators; MarR family transcriptional regulator 750205 rmaA 1114368 rmaA Lactococcus lactis subsp. lactis Il1403 MarR family transcriptional regulator NP_266898.1 749729 R 272623 CDS NP_266899.1 15672725 1114369 750333..751001 1 NC_002662.1 Similar to phosphoglucomutases and phosphoglycolate phosphatases from different species; hypothetical protein 751001 yhfA 1114369 yhfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266899.1 750333 D 272623 CDS NP_266900.1 15672726 1114370 751095..753059 1 NC_002662.1 similar to YybT of Bacillus subtilis; hypothetical protein 753059 yhfB 1114370 yhfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266900.1 751095 D 272623 CDS NP_266901.1 15672727 1114371 753056..753508 1 NC_002662.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 753508 rplI 1114371 rplI Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L9 NP_266901.1 753056 D 272623 CDS NP_266902.1 15672728 1114372 753514..754881 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; corresponds to the dnaC gene from Bacillus subtilis; replicative DNA helicase 754881 dnaC 1114372 dnaC Lactococcus lactis subsp. lactis Il1403 replicative DNA helicase NP_266902.1 753514 D 272623 CDS NP_266903.1 15672729 1114373 755076..755333 1 NC_002662.1 hypothetical protein 755333 yhfC 1114373 yhfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266903.1 755076 D 272623 CDS NP_266904.1 15672730 1114374 755402..756175 1 NC_002662.1 similar to YtmP of Bacillus subtilis; hypothetical protein 756175 yhfD 1114374 yhfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266904.1 755402 D 272623 CDS NP_266905.1 15672731 1114375 756296..756949 1 NC_002662.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 756949 trmB 1114375 trmB Lactococcus lactis subsp. lactis Il1403 tRNA (guanine-N(7)-)-methyltransferase NP_266905.1 756296 D 272623 CDS NP_266906.1 15672732 1114376 757068..757514 1 NC_002662.1 transcriptional regulator NrdR 757514 nrdR 1114376 nrdR Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NrdR NP_266906.1 757068 D 272623 CDS NP_835302.1 30024009 1114377 complement(757501..757836) 1 NC_002662.1 hypothetical protein 757836 1114377 L200028 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835302.1 757501 R 272623 CDS NP_266907.1 15672733 1114378 757902..759077 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; replication protein; counterpart to the Bacillus subtilis DnaB protein, based on sequence similarity and chromosomal position; hypothetical protein 759077 dnaB 1114378 dnaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266907.1 757902 D 272623 CDS NP_266908.1 15672734 1114379 759077..759958 1 NC_002662.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 759958 dnaI 1114379 dnaI Lactococcus lactis subsp. lactis Il1403 primosomal protein DnaI NP_266908.1 759077 D 272623 CDS NP_266909.1 15672735 1114380 759951..760679 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 760679 yhgA 1114380 yhgA Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_266909.1 759951 D 272623 CDS NP_266910.1 15672736 1114381 760781..761296 1 NC_002662.1 similar to YisX of Bacillus subtilis; hypothetical protein 761296 yhgB 1114381 yhgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266910.1 760781 D 272623 CDS NP_266911.1 15672737 1114382 761403..762713 1 NC_002662.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 762713 engA 1114382 engA Lactococcus lactis subsp. lactis Il1403 GTP-binding protein EngA NP_266911.1 761403 D 272623 CDS NP_266912.1 15672738 1114383 762819..763631 1 NC_002662.1 similar to positive regulator GadR of Lactococcus lactis; transcriptional regulator 763631 yhgC 1114383 yhgC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266912.1 762819 D 272623 CDS NP_266913.1 15672739 1114384 764114..767656 1 NC_002662.1 hypothetical protein 767656 yhgD 1114384 yhgD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266913.1 764114 D 272623 CDS NP_266914.1 15672740 1114385 767788..769632 1 NC_002662.1 hypothetical protein 769632 yhgE 1114385 yhgE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266914.1 767788 D 272623 CDS NP_266915.1 15672741 1114386 769694..770992 1 NC_002662.1 similar to fimbria-associated protein from Actinomyces naeslundii; integral membrane protein; hypothetical protein 770992 yhhA 1114386 yhhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266915.1 769694 D 272623 CDS NP_266916.1 15672742 1114387 770979..771704 1 NC_002662.1 hypothetical protein 771704 yhhB 1114387 yhhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266916.1 770979 D 272623 CDS NP_266917.1 15672743 1114388 complement(771778..772476) 1 NC_002662.1 integral membrane protein; hypothetical protein 772476 yhhC 1114388 yhhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266917.1 771778 R 272623 CDS NP_266918.1 15672744 1114389 complement(772495..772899) 1 NC_002662.1 similar to PH1801 of Pyrococcus horikoshii.; hypothetical protein 772899 yhhD 1114389 yhhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266918.1 772495 R 272623 CDS NP_266919.1 15672745 1114390 773172..773645 1 NC_002662.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 773645 yhhE 1114390 yhhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266919.1 773172 D 272623 CDS NP_266920.1 15672746 1114391 773810..774958 1 NC_002662.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 774958 nusA 1114391 nusA Lactococcus lactis subsp. lactis Il1403 transcription elongation factor NusA NP_266920.1 773810 D 272623 CDS NP_266921.1 15672747 1114392 775124..775450 1 NC_002662.1 hypothetical protein 775450 yhhG 1114392 yhhG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266921.1 775124 D 272623 CDS NP_266922.1 15672748 1114393 775453..775758 1 NC_002662.1 ribosomal proteins; synthesis and modification; similar to YlxQ of Bacillus subtilis, supposed to be a ribosomal protein. Located close to the genes implicated in protein biosynthesis.; hypothetical protein 775758 ylxQ 1114393 ylxQ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266922.1 775453 D 272623 CDS NP_266923.1 15672749 1114394 775779..778613 1 NC_002662.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 778613 infB 1114394 infB Lactococcus lactis subsp. lactis Il1403 translation initiation factor IF-2 NP_266923.1 775779 D 272623 CDS NP_266924.1 15672750 1114395 778883..779242 1 NC_002662.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 779242 rbfA 1114395 rbfA Lactococcus lactis subsp. lactis Il1403 ribosome-binding factor A NP_266924.1 778883 D 272623 CDS NP_266925.1 15672751 1114396 779421..780368 1 NC_002662.1 mannose-6-phosphate isomerase 780368 pmi 1114396 pmi Lactococcus lactis subsp. lactis Il1403 mannose-6-phosphate isomerase NP_266925.1 779421 D 272623 CDS NP_266926.1 15672752 1114397 780787..781227 1 NC_002662.1 MarR-family regulator; MarR family transcriptional regulator 781227 rmaG 1114397 rmaG Lactococcus lactis subsp. lactis Il1403 MarR family transcriptional regulator NP_266926.1 780787 D 272623 CDS NP_266927.1 15672753 1114398 781227..782204 1 NC_002662.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 782204 fabH 1114398 fabH Lactococcus lactis subsp. lactis Il1403 3-oxoacyl-ACP synthase NP_266927.1 781227 D 272623 CDS NP_266928.1 15672754 1114399 782371..782592 1 NC_002662.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 782592 acpP 1114399 acpP Lactococcus lactis subsp. lactis Il1403 acyl carrier protein NP_266928.1 782371 D 272623 CDS NP_266929.1 15672755 1114400 782872..783798 1 NC_002662.1 fatty acid and phospholipid metabolism; ACP S-malonyltransferase 783798 fabD 1114400 fabD Lactococcus lactis subsp. lactis Il1403 ACP S-malonyltransferase NP_266929.1 782872 D 272623 CDS NP_266930.1 15672756 1114401 783884..784615 1 NC_002662.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 784615 fabG 1114401 fabG Lactococcus lactis subsp. lactis Il1403 3-ketoacyl-ACP reductase NP_266930.1 783884 D 272623 CDS NP_266931.1 15672757 1114402 784656..785885 1 NC_002662.1 fatty acid and phospholipid metabolism; 3-oxoacyl-ACP synthase 785885 fabF 1114402 fabF Lactococcus lactis subsp. lactis Il1403 3-oxoacyl-ACP synthase NP_266931.1 784656 D 272623 CDS NP_266932.1 15672758 1114403 785892..786359 1 NC_002662.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 786359 accB 1114403 accB Lactococcus lactis subsp. lactis Il1403 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_266932.1 785892 D 272623 CDS NP_266933.1 15672759 1114404 786486..786920 1 NC_002662.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 786920 fabZ 1114404 fabZ Lactococcus lactis subsp. lactis Il1403 (3R)-hydroxymyristoyl-ACP dehydratase NP_266933.1 786486 D 272623 CDS NP_266934.1 15672760 1114405 787314..788681 1 NC_002662.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 788681 accC 1114405 accC Lactococcus lactis subsp. lactis Il1403 acetyl-CoA carboxylase biotin carboxylase subunit NP_266934.1 787314 D 272623 CDS NP_266935.1 15672761 1114406 788767..789633 1 NC_002662.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 789633 accD 1114406 accD Lactococcus lactis subsp. lactis Il1403 acetyl-CoA carboxylase subunit beta NP_266935.1 788767 D 272623 CDS NP_266936.1 15672762 1114407 789626..790408 1 NC_002662.1 fatty acid and phospholipid metabolism; acetyl-CoA carboxylase carboxyl transferase subunit alpha 790408 accA 1114407 accA Lactococcus lactis subsp. lactis Il1403 acetyl-CoA carboxylase carboxyl transferase subunit alpha NP_266936.1 789626 D 272623 CDS NP_266937.1 15672763 1114408 790537..791679 1 NC_002662.1 catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine; cystathionine gamma-synthase 791679 metB2 1114408 metB2 Lactococcus lactis subsp. lactis Il1403 cystathionine gamma-synthase NP_266937.1 790537 D 272623 CDS NP_266938.1 15672764 1114409 791894..792814 1 NC_002662.1 serine family; there is another potential cysteine synthase cysM in the genome; cysteine synthase 792814 cysK 1114409 cysK Lactococcus lactis subsp. lactis Il1403 cysteine synthase NP_266938.1 791894 D 272623 CDS NP_266939.1 15672765 1114410 793043..793282 1 NC_002662.1 hypothetical protein 793282 yhjA 1114410 yhjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266939.1 793043 D 272623 CDS NP_266940.1 15672766 1114411 793339..793716 1 NC_002662.1 hypothetical protein 793716 yhjB 1114411 yhjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266940.1 793339 D 272623 CDS NP_266941.1 15672767 1114412 793727..794035 1 NC_002662.1 hypothetical protein 794035 yhjC 1114412 yhjC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266941.1 793727 D 272623 CDS NP_266942.1 15672768 1114413 794032..795675 1 NC_002662.1 aerobic energy metabolism; NADH oxidase 795675 noxC 1114413 noxC Lactococcus lactis subsp. lactis Il1403 NADH oxidase NP_266942.1 794032 D 272623 CDS NP_266943.1 15672769 1114414 795702..795956 1 NC_002662.1 similar to YrkD of Bacillus subtilis; hypothetical protein 795956 yhjE 1114414 yhjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266943.1 795702 D 272623 CDS NP_266944.1 15672770 1114415 796032..796382 1 NC_002662.1 hypothetical protein 796382 yhjF 1114415 yhjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266944.1 796032 D 272623 CDS NP_266945.1 15672771 1114416 complement(796549..797292) 1 NC_002662.1 DeoR-family regulators; transcriptional regulator 797292 rdrA 1114416 rdrA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266945.1 796549 R 272623 CDS NP_266946.1 15672772 1114417 complement(797386..797949) 1 NC_002662.1 ribosomal proteins: synthesis and modification; acetyl transferase 797949 yhjG 1114417 yhjG Lactococcus lactis subsp. lactis Il1403 acetyl transferase NP_266946.1 797386 R 272623 CDS NP_266947.1 15672773 1114418 complement(798032..799036) 1 NC_002662.1 degradation of DNA; AP/EXOA family of DNA repair enzymes; exodeoxyribonuclease A 799036 exoA 1114418 exoA Lactococcus lactis subsp. lactis Il1403 exodeoxyribonuclease A NP_266947.1 798032 R 272623 CDS NP_266948.1 15672774 1114419 799071..801059 1 NC_002662.1 amino acyl tRNA synthetases; methyonyl-tRNA synthetase 801059 metS 1114419 metS Lactococcus lactis subsp. lactis Il1403 methyonyl-tRNA synthetase NP_266948.1 799071 D 272623 CDS NP_266949.1 15672775 1114420 801265..801504 1 NC_002662.1 hypothetical protein 801504 yiaA 1114420 yiaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266949.1 801265 D 272623 CDS NP_266950.1 15672776 1114421 801521..802252 1 NC_002662.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 802252 fabG 1114421 fabG Lactococcus lactis subsp. lactis Il1403 3-ketoacyl-ACP reductase NP_266950.1 801521 D 272623 CDS NP_266951.1 15672777 1114422 802593..803165 1 NC_002662.1 hypothetical protein 803165 yiaC 1114422 yiaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266951.1 802593 D 272623 CDS NP_266952.1 15672778 1114423 803269..803901 1 NC_002662.1 similar to YwnB protein of Bacillus subtilis; probably nucleoside-diphosphate-sugar epimerase, evidenced by COGnitor; NADH-flavin reductase 803901 yiaD 1114423 yiaD Lactococcus lactis subsp. lactis Il1403 NADH-flavin reductase NP_266952.1 803269 D 272623 CDS NP_266953.1 15672779 1114424 804041..805063 1 NC_002662.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 805063 argC 1114424 argC Lactococcus lactis subsp. lactis Il1403 N-acetyl-gamma-glutamyl-phosphate reductase NP_266953.1 804041 D 272623 CDS NP_266954.1 15672780 1114425 805075..806265 1 NC_002662.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 806265 argJ 1114425 argJ Lactococcus lactis subsp. lactis Il1403 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase NP_266954.1 805075 D 272623 CDS NP_266955.1 15672781 1114426 806278..807411 1 NC_002662.1 glutamate family; acetylornithine aminotransferase 807411 argD 1114426 argD Lactococcus lactis subsp. lactis Il1403 acetylornithine aminotransferase NP_266955.1 806278 D 272623 CDS NP_266956.1 15672782 1114427 807408..808259 1 NC_002662.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 808259 argB 1114427 argB Lactococcus lactis subsp. lactis Il1403 acetylglutamate kinase NP_266956.1 807408 D 272623 CDS NP_266957.1 15672783 1114428 808287..809288 1 NC_002662.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 809288 argF 1114428 argF Lactococcus lactis subsp. lactis Il1403 ornithine carbamoyltransferase NP_266957.1 808287 D 272623 CDS NP_266958.1 15672784 1114429 809461..810156 1 NC_002662.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 810156 rnc 1114429 rnc Lactococcus lactis subsp. lactis Il1403 ribonuclease III NP_266958.1 809461 D 272623 CDS NP_266961.1 15672787 1114432 813912..816080 1 NC_002662.1 hypothetical protein 816080 yibC 1114432 yibC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266961.1 813912 D 272623 CDS NP_266962.1 15672788 1114433 816171..816581 1 NC_002662.1 hypothetical protein 816581 yibD 1114433 yibD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266962.1 816171 D 272623 CDS NP_266963.1 15672789 1114434 816609..817790 1 NC_002662.1 hypothetical protein 817790 yibE 1114434 yibE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266963.1 816609 D 272623 CDS NP_266964.1 15672790 1114435 817787..818548 1 NC_002662.1 hypothetical protein 818548 yibF 1114435 yibF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266964.1 817787 D 272623 CDS NP_266965.1 15672791 1114436 complement(818598..819938) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 819938 yibG 1114436 yibG Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_266965.1 818598 R 272623 CDS NP_266966.1 15672792 1114437 820452..822542 1 NC_002662.1 hypothetical protein 822542 yicA 1114437 yicA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266966.1 820452 D 272623 CDS NP_266967.1 15672793 1114438 822669..823478 1 NC_002662.1 hypothetical protein 823478 yicB 1114438 yicB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266967.1 822669 D 272623 CDS NP_266968.1 15672794 1114439 823488..824039 1 NC_002662.1 integral membrane protein; hypothetical protein 824039 yicC 1114439 yicC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266968.1 823488 D 272623 CDS NP_266969.1 15672795 1114440 824101..825480 1 NC_002662.1 cell division protein; hypothetical protein 825480 ftsY 1114440 ftsY Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266969.1 824101 D 272623 CDS NP_266970.1 15672796 1114441 825656..826630 1 NC_002662.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 826630 prsA 1114441 prsA Lactococcus lactis subsp. lactis Il1403 ribose-phosphate pyrophosphokinase NP_266970.1 825656 D 272623 CDS NP_266971.1 15672797 1114442 826703..827374 1 NC_002662.1 hypothetical protein 827374 yicE 1114442 yicE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266971.1 826703 D 272623 CDS NP_266972.1 15672798 1114443 827445..829934 1 NC_002662.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 829934 leuS 1114443 leuS Lactococcus lactis subsp. lactis Il1403 leucyl-tRNA synthetase NP_266972.1 827445 D 272623 CDS NP_266973.1 15672799 1114444 830200..830955 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 830955 yidA 1114444 yidA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266973.1 830200 D 272623 CDS NP_266974.1 15672800 1114445 831369..832787 1 NC_002662.1 transport and binding protein; PTS system; PTS system cellobiose-specific transporter subunit IIC 832787 yidB 1114445 yidB Lactococcus lactis subsp. lactis Il1403 PTS system cellobiose-specific transporter subunit IIC NP_266974.1 831369 D 272623 CDS NP_266975.1 15672801 1114446 832872..834233 1 NC_002662.1 energy metabolism, Sugars; beta-glucosidase family; beta-glucosidase 834233 yidC 1114446 yidC Lactococcus lactis subsp. lactis Il1403 beta-glucosidase NP_266975.1 832872 D 272623 CDS NP_266976.1 15672802 1114447 834485..835288 1 NC_002662.1 adaptations and atypical conditions; belongs to chloro/bromoperoxidase family.; non-heme chloride peroxidase 835288 cpo 1114447 cpo Lactococcus lactis subsp. lactis Il1403 non-heme chloride peroxidase NP_266976.1 834485 D 272623 CDS NP_266977.1 15672803 1114448 835448..835810 1 NC_002662.1 hypothetical protein 835810 yidE 1114448 yidE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266977.1 835448 D 272623 CDS NP_266978.1 15672804 1114449 complement(835893..836654) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904F 836654 tra904F 1114449 tra904F Lactococcus lactis subsp. lactis Il1403 transposase of IS904F NP_266978.1 835893 R 272623 CDS NP_266979.1 15672805 1114450 complement(836750..837040) 1 NC_002662.1 transposon related function; hypothetical protein 837040 yidF 1114450 yidF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266979.1 836750 R 272623 CDS NP_266980.1 15672806 1114451 complement(837114..837932) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase; IS1077E transposase 837932 tra1077E 1114451 tra1077E Lactococcus lactis subsp. lactis Il1403 IS1077E transposase NP_266980.1 837114 R 272623 CDS NP_266981.1 15672807 1114452 complement(837929..838486) 1 NC_002662.1 transposon related function; hypothetical protein 838486 yidG 1114452 yidG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266981.1 837929 R 272623 CDS NP_266982.1 15672808 1114453 838561..838851 1 NC_002662.1 transposon related function; hypothetical protein 838851 yidH 1114453 yidH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266982.1 838561 D 272623 CDS NP_266983.1 15672809 1114454 838947..839708 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904G 839708 tra904G 1114454 tra904G Lactococcus lactis subsp. lactis Il1403 transposase of IS904G NP_266983.1 838947 D 272623 CDS NP_266984.1 15672810 1114455 839911..841170 1 NC_002662.1 aerobic energy metabolism; NADH dehydrogenase 841170 noxA 1114455 noxA Lactococcus lactis subsp. lactis Il1403 NADH dehydrogenase NP_266984.1 839911 D 272623 CDS NP_266985.1 15672811 1114456 841314..843317 1 NC_002662.1 aerobic energy metabolism; NADH dehydrogenase 843317 noxB 1114456 noxB Lactococcus lactis subsp. lactis Il1403 NADH dehydrogenase NP_266985.1 841314 D 272623 CDS NP_266986.1 15672812 1114457 843431..844102 1 NC_002662.1 energy metabolism, amino acids and amines; gluconeogenesis; produces pyruvate; beta-subunit of L-serine dehydratase 844102 sdaB 1114457 sdaB Lactococcus lactis subsp. lactis Il1403 beta-subunit of L-serine dehydratase NP_266986.1 843431 D 272623 CDS NP_266987.1 15672813 1114458 844122..844985 1 NC_002662.1 energy metabolism, amino acids and amines; gluconeogenesis; produces pyruvate; alpha-subuni L-serine dehydratase 844985 sdaA 1114458 sdaA Lactococcus lactis subsp. lactis Il1403 alpha-subuni L-serine dehydratase NP_266987.1 844122 D 272623 CDS NP_266988.1 15672814 1114459 845106..845561 1 NC_002662.1 general regulatory function; transcriptional regulator 845561 copR 1114459 copR Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_266988.1 845106 D 272623 CDS NP_266989.1 15672815 1114460 845577..845777 1 NC_002662.1 transport and binding protein, cations; similar to N-part of many mercuric reductases; probably involved in cation transport, because of the visinity of corresponding genes; mercuric reductase 845777 yieF 1114460 yieF Lactococcus lactis subsp. lactis Il1403 mercuric reductase NP_266989.1 845577 D 272623 CDS NP_266990.1 15672816 1114461 845963..848125 1 NC_002662.1 transort and binding protein, cations; copper/potassium-transporting ATPase 848125 copA 1114461 copA Lactococcus lactis subsp. lactis Il1403 copper/potassium-transporting ATPase NP_266990.1 845963 D 272623 CDS NP_266991.1 15672817 1114462 complement(848313..850964) 1 NC_002662.1 identified also as transmembrane protein Tmp5. similar to YfhO of Bacillus subtilis; hypothetical protein 850964 yieH 1114462 yieH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266991.1 848313 R 272623 CDS NP_266992.1 15672818 1114463 complement(851035..851820) 1 NC_002662.1 hypothetical protein 851820 yifA 1114463 yifA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_266992.1 851035 R 272623 CDS NP_266993.1 15672819 1114464 852072..853226 1 NC_002662.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 853226 mnmA 1114464 mnmA Lactococcus lactis subsp. lactis Il1403 tRNA-specific 2-thiouridylase MnmA NP_266993.1 852072 D 272623 CDS NP_266994.1 15672820 1114465 853437..854663 1 NC_002662.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 854663 rpsA 1114465 rpsA Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S1 NP_266994.1 853437 D 272623 CDS NP_266995.1 15672821 1114466 854814..855530 1 NC_002662.1 salvage of nucleosides and nucleotides; uridine phosphorylase 855530 udp 1114466 udp Lactococcus lactis subsp. lactis Il1403 uridine phosphorylase NP_266995.1 854814 D 272623 CDS NP_266996.1 15672822 1114468 856467..858473 1 NC_002662.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 858473 uvrC 1114468 uvrC Lactococcus lactis subsp. lactis Il1403 excinuclease ABC subunit C NP_266996.1 856467 D 272623 CDS NP_266997.1 15672823 1114469 858637..859800 1 NC_002662.1 A/G-specific adenine glycosylase 859800 mutY 1114469 mutY Lactococcus lactis subsp. lactis Il1403 A/G-specific adenine glycosylase NP_266997.1 858637 D 272623 CDS NP_266998.1 15672824 1114470 859866..861284 1 NC_002662.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 861284 pepV 1114470 pepV Lactococcus lactis subsp. lactis Il1403 dipeptidase PepV NP_266998.1 859866 D 272623 CDS NP_266999.1 15672825 1114471 861387..861746 1 NC_002662.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 861746 acpS 1114471 acpS Lactococcus lactis subsp. lactis Il1403 4'-phosphopantetheinyl transferase NP_266999.1 861387 D 272623 CDS NP_267000.1 15672826 1114472 861791..862894 1 NC_002662.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 862894 alr 1114472 alr Lactococcus lactis subsp. lactis Il1403 alanine racemase NP_267000.1 861791 D 272623 CDS NP_267001.1 15672827 1114473 863010..863438 1 NC_002662.1 hypothetical protein 863438 yigC 1114473 yigC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267001.1 863010 D 272623 CDS NP_267002.1 15672828 1114474 863576..864883 1 NC_002662.1 thioredoxin, glutaredoxin, and glutathione; glutathione reductase 864883 gshR 1114474 gshR Lactococcus lactis subsp. lactis Il1403 glutathione reductase NP_267002.1 863576 D 272623 CDS NP_267003.1 15672829 1114475 865009..865926 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; maybe involved in osmoprotection; substrate can be also proline or glycine; choline ABC transporter ATP binding protein 865926 choQ 1114475 choQ Lactococcus lactis subsp. lactis Il1403 choline ABC transporter ATP binding protein NP_267003.1 865009 D 272623 CDS NP_267004.1 15672830 1114476 865923..867425 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; maybe involved in osmoprotection; substrate can be also proline or glycine; permease and substrate binding functions are in the same protein; choline ABC transporter permease and substrate binding protein 867425 choS 1114476 choS Lactococcus lactis subsp. lactis Il1403 choline ABC transporter permease and substrate binding protein NP_267004.1 865923 D 272623 CDS NP_835303.1 30024010 1114477 867714..869597 1 NC_002662.1 hypothetical protein 869597 1114477 L200030 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835303.1 867714 D 272623 CDS NP_267005.1 15672831 1114478 870129..870722 1 NC_002662.1 hypothetical protein 870722 yihA 1114478 yihA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267005.1 870129 D 272623 CDS NP_267006.1 15672832 1114479 870719..871171 1 NC_002662.1 hypothetical protein 871171 yihB 1114479 yihB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267006.1 870719 D 272623 CDS NP_267007.1 15672833 1114480 complement(871221..873308) 1 NC_002662.1 transort and binding protein, cations; copper-potassium transporting ATPase B 873308 copB 1114480 copB Lactococcus lactis subsp. lactis Il1403 copper-potassium transporting ATPase B NP_267007.1 871221 R 272623 CDS NP_267008.1 15672834 1114481 873509..876700 1 NC_002662.1 hypothetical protein 876700 yihD 1114481 yihD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267008.1 873509 D 272623 CDS NP_267009.1 15672835 1114482 876830..877714 1 NC_002662.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 877714 folD 1114482 folD Lactococcus lactis subsp. lactis Il1403 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_267009.1 876830 D 272623 CDS NP_267010.1 15672836 1114483 877881..879134 1 NC_002662.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 879134 xseA 1114483 xseA Lactococcus lactis subsp. lactis Il1403 exodeoxyribonuclease VII large subunit NP_267010.1 877881 D 272623 CDS NP_267011.1 15672837 1114484 879134..879373 1 NC_002662.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 879373 xseB 1114484 xseB Lactococcus lactis subsp. lactis Il1403 exodeoxyribonuclease VII small subunit NP_267011.1 879134 D 272623 CDS NP_267012.1 15672838 1114485 879522..880679 1 NC_002662.1 hypothetical protein 880679 yihF 1114485 yihF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267012.1 879522 D 272623 CDS NP_267013.1 15672839 1114486 880761..881618 1 NC_002662.1 menaquinone and ubiquinone; side chain synthesis, also isoprenoid, carotenoid biosynthesis; belongs to a family that groups together FFP synthetase, GGPP synthetase and hexaprenyl pyrophosphate synthetase; farnesyl diphosphate synthase 881618 ispA 1114486 ispA Lactococcus lactis subsp. lactis Il1403 farnesyl diphosphate synthase NP_267013.1 880761 D 272623 CDS NP_267014.1 15672840 1114487 881773..882504 1 NC_002662.1 hemolysin-like protein; similar to hemolysin A; hypothetical protein 882504 yiiB 1114487 yiiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267014.1 881773 D 272623 CDS NP_267015.1 15672841 1114488 882501..882947 1 NC_002662.1 similar to several AhrC proteins from different species; transcriptional regulator 882947 ahrC 1114488 ahrC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267015.1 882501 D 272623 CDS NP_267016.1 15672842 1114489 883095..884762 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; may be involved in recombinational repair of damaged DNA; DNA repair protein RecN 884762 recN 1114489 recN Lactococcus lactis subsp. lactis Il1403 DNA repair protein RecN NP_267016.1 883095 D 272623 CDS NP_267017.1 15672843 1114490 884881..885111 1 NC_002662.1 hypothetical protein 885111 yiiD 1114490 yiiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267017.1 884881 D 272623 CDS NP_267018.1 15672844 1114491 885488..886054 1 NC_002662.1 hypothetical protein 886054 yiiE 1114491 yiiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267018.1 885488 D 272623 CDS NP_267019.1 15672845 1114492 886152..886673 1 NC_002662.1 transport and binding protein; transporter 886673 yiiF 1114492 yiiF Lactococcus lactis subsp. lactis Il1403 transporter NP_267019.1 886152 D 272623 CDS NP_267020.1 15672846 1114493 886696..887634 1 NC_002662.1 hypothetical protein 887634 yiiG 1114493 yiiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267020.1 886696 D 272623 CDS NP_267021.1 15672847 1114494 887854..888807 1 NC_002662.1 S-adenosyl-methyltransferase MraW 888807 mraW 1114494 mraW Lactococcus lactis subsp. lactis Il1403 S-adenosyl-methyltransferase MraW NP_267021.1 887854 D 272623 CDS NP_267022.1 15672848 1114495 888965..889345 1 NC_002662.1 membrane protein; hypothetical protein 889345 yiiI 1114495 yiiI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267022.1 888965 D 272623 CDS NP_267023.1 15672849 1114496 889342..891633 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; penicillin-binding protein 891633 pbpX 1114496 pbpX Lactococcus lactis subsp. lactis Il1403 penicillin-binding protein NP_267023.1 889342 D 272623 CDS NP_267024.1 15672850 1114497 891698..892687 1 NC_002662.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 892687 mraY 1114497 mraY Lactococcus lactis subsp. lactis Il1403 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_267024.1 891698 D 272623 CDS NP_267025.1 15672851 1114498 892887..893165 1 NC_002662.1 hypothetical protein 893165 yijB 1114498 yijB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267025.1 892887 D 272623 CDS NP_267026.1 15672852 1114499 893298..894818 1 NC_002662.1 transport and binding protein; ABC transporter permease 894818 yijC 1114499 yijC Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_267026.1 893298 D 272623 CDS NP_267028.1 15672854 1114502 895741..896616 1 NC_002662.1 evidence experimental PMID:2498286; LysR-family regulators; malolactic fermentation system transcription activator 896616 mleR 1114502 mleR Lactococcus lactis subsp. lactis Il1403 malolactic fermentation system transcription activator NP_267028.1 895741 D 272623 CDS NP_267029.1 15672855 1114503 896856..897530 1 NC_002662.1 similar to YwaC of Bacillus subtilis; hypothetical protein 897530 yijE 1114503 yijE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267029.1 896856 D 272623 CDS NP_267030.1 15672856 1114504 897638..898015 1 NC_002662.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 898015 rplS 1114504 rplS Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L19 NP_267030.1 897638 D 272623 CDS NP_267031.1 15672857 1114505 898311..898820 1 NC_002662.1 hypothetical protein 898820 yijF 1114505 yijF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267031.1 898311 D 272623 CDS NP_267032.1 15672858 1114506 898813..900141 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaA of Staphylococcus epidermidis; glycosyl transferase family protein 900141 yijG 1114506 yijG Lactococcus lactis subsp. lactis Il1403 glycosyl transferase family protein NP_267032.1 898813 D 272623 CDS NP_267033.1 15672859 1114507 900367..900903 1 NC_002662.1 hypothetical protein 900903 yijH 1114507 yijH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267033.1 900367 D 272623 CDS NP_267034.1 15672860 1114508 901102..901833 1 NC_002662.1 transport and binding protein; nucleosides, purines and pyrimidines; nicotinamide mononucleotide transporter 901833 pnuC2 1114508 pnuC2 Lactococcus lactis subsp. lactis Il1403 nicotinamide mononucleotide transporter NP_267034.1 901102 D 272623 CDS NP_267035.1 15672861 1114509 902361..902786 1 NC_002662.1 hypothetical protein 902786 yjaB 1114509 yjaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267035.1 902361 D 272623 CDS NP_267036.1 15672862 1114510 902908..903255 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; HU-like DNA-binding protein 903255 hslB 1114510 hslB Lactococcus lactis subsp. lactis Il1403 HU-like DNA-binding protein NP_267036.1 902908 D 272623 CDS NP_267037.1 15672863 1114511 complement(903327..903860) 1 NC_002662.1 belongs to TetR/AcrR family; transcriptional regulator 903860 yjaD 1114511 yjaD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267037.1 903327 R 272623 CDS NP_267038.1 15672864 1114512 904024..906423 1 NC_002662.1 transmembrane protein, similar to phage infection protein Pip; hypothetical protein 906423 yjaE 1114512 yjaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267038.1 904024 D 272623 CDS NP_267039.1 15672865 1114513 906609..906941 1 NC_002662.1 probably aromatic ring hydroxylating enzyme, evidenced by COGnitor; hypothetical protein 906941 yjaF 1114513 yjaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267039.1 906609 D 272623 CDS NP_267040.1 15672866 1114514 907791..908990 1 NC_002662.1 cell division protein; similar to cell division protein FtsW of Enterococcus hirae; hypothetical protein 908990 ftsW2 1114514 ftsW2 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267040.1 907791 D 272623 CDS NP_267044.1 15672870 1114518 910421..910690 1 NC_002662.1 30S ribosomal protein S14 910690 rpsN2 1114518 rpsN2 Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S14 NP_267044.1 910421 D 272623 CDS NP_267045.1 15672871 1114519 910856..911485 1 NC_002662.1 hypothetical protein 911485 yjbB 1114519 yjbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267045.1 910856 D 272623 CDS NP_267046.1 15672872 1114520 911482..912480 1 NC_002662.1 evidence experimental PMID:9172368; two-component system; sensor protein kinase 912480 kinD 1114520 kinD Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267046.1 911482 D 272623 CDS NP_267047.1 15672873 1114521 912508..913137 1 NC_002662.1 evidence experimental PMID:10708382; two-component system; involved in salt and osmotic stress resistance development; two-component system regulator 913137 llrD 1114521 llrD Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267047.1 912508 D 272623 CDS NP_267048.1 15672874 1114522 913208..914014 1 NC_002662.1 hypothetical protein 914014 yjbC 1114522 yjbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267048.1 913208 D 272623 CDS NP_267049.1 15672875 1114523 914117..914707 1 NC_002662.1 translation; protein modification; peptidyl-prolyl cis-trans isomerase 914707 ppiB 1114523 ppiB Lactococcus lactis subsp. lactis Il1403 peptidyl-prolyl cis-trans isomerase NP_267049.1 914117 D 272623 CDS NP_267050.1 15672876 1114524 914709..915140 1 NC_002662.1 adaptations and atypical conditions; polyribonucleotide nucleotidyltransferase; general stress protein GSP13 915140 yjbE 1114524 yjbE Lactococcus lactis subsp. lactis Il1403 general stress protein GSP13 NP_267050.1 914709 D 272623 CDS NP_267051.1 15672877 1114525 915137..915742 1 NC_002662.1 hypothetical protein 915742 yjbF 1114525 yjbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267051.1 915137 D 272623 CDS NP_267052.1 15672878 1114526 915962..917206 1 NC_002662.1 cell division; similar to rod-shape determining proteins from different species; rod-shape determining protein 917206 rodA 1114526 rodA Lactococcus lactis subsp. lactis Il1403 rod-shape determining protein NP_267052.1 915962 D 272623 CDS NP_267053.2 30024012 1114527 917431..918501 1 NC_002662.1 energy metabolism; fermentation; 2,3-butanediol dehydrogenase 918501 butB 1114527 butB Lactococcus lactis subsp. lactis Il1403 2,3-butanediol dehydrogenase NP_267053.2 917431 D 272623 CDS NP_267054.1 15672880 1114528 918527..919288 1 NC_002662.1 fermentation; acetoin reductase 919288 butA 1114528 butA Lactococcus lactis subsp. lactis Il1403 acetoin reductase NP_267054.1 918527 D 272623 CDS NP_267055.1 15672881 1114529 919808..921349 1 NC_002662.1 transport and binding protein; contains two ATP binding domains; ABC transporter ATP-binding protein 921349 yjcA 1114529 yjcA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267055.1 919808 D 272623 CDS NP_267056.1 15672882 1114530 921766..923388 1 NC_002662.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 923388 mleS 1114530 mleS Lactococcus lactis subsp. lactis Il1403 malate dehydrogenase NP_267056.1 921766 D 272623 CDS NP_267057.1 15672883 1114531 923403..924680 1 NC_002662.1 evidence experimental PMID:8405453; transport and binding protein; carbohydrates, organic alcohols and acids; malate transporter 924680 mleP 1114531 mleP Lactococcus lactis subsp. lactis Il1403 malate transporter NP_267057.1 923403 D 272623 CDS NP_267058.1 15672884 1114532 924977..925909 1 NC_002662.1 hypothetical protein 925909 yjcD 1114532 yjcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267058.1 924977 D 272623 CDS NP_267059.1 15672885 1114533 925990..927081 1 NC_002662.1 hypothetical protein 927081 yjcE 1114533 yjcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267059.1 925990 D 272623 CDS NP_267060.1 15672886 1114534 927135..927782 1 NC_002662.1 hypothetical protein 927782 yjcF 1114534 yjcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267060.1 927135 D 272623 CDS NP_267061.1 15672887 1114535 927935..929890 1 NC_002662.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 929890 gyrB 1114535 gyrB Lactococcus lactis subsp. lactis Il1403 DNA gyrase subunit B NP_267061.1 927935 D 272623 CDS NP_267062.1 15672888 1114536 930397..931134 1 NC_002662.1 hypothetical protein 931134 yjdA 1114536 yjdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267062.1 930397 D 272623 CDS NP_267063.1 15672889 1114537 931316..931921 1 NC_002662.1 hypothetical protein 931921 yjdB 1114537 yjdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267063.1 931316 D 272623 CDS NP_267064.1 15672890 1114538 932070..932534 1 NC_002662.1 MarR-family regulators; transcriptional regulator 932534 rmaH 1114538 rmaH Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267064.1 932070 D 272623 CDS NP_267065.1 15672891 1114539 932527..934071 1 NC_002662.1 transport and binding protein; multidrug resistance protein 934071 yjdE 1114539 yjdE Lactococcus lactis subsp. lactis Il1403 multidrug resistance protein NP_267065.1 932527 D 272623 CDS NP_267066.1 15672892 1114540 934071..934790 1 NC_002662.1 hypothetical protein 934790 yjdF 1114540 yjdF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267066.1 934071 D 272623 CDS NP_267067.1 15672893 1114541 935545..935880 1 NC_002662.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000; transcriptional regulator 935880 tagR 1114541 tagR Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267067.1 935545 D 272623 CDS NP_267068.1 15672894 1114542 935988..936896 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to EpsL protein of exopolysaccharide biosynthesis operons of S.thermophilus and l.lactis NIZO B35; exopolysaccharide biosynthesis protein 936896 tagL 1114542 tagL Lactococcus lactis subsp. lactis Il1403 exopolysaccharide biosynthesis protein NP_267068.1 935988 D 272623 CDS NP_267069.1 15672895 1114543 936920..937204 1 NC_002662.1 hypothetical protein 937204 yjdI 1114543 yjdI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267069.1 936920 D 272623 CDS NP_267070.1 15672896 1114544 937270..937692 1 NC_002662.1 transort and binding protein, cations; potassium channel protein 937692 yjdJ 1114544 yjdJ Lactococcus lactis subsp. lactis Il1403 potassium channel protein NP_267070.1 937270 D 272623 CDS NP_267071.1 15672897 1114545 937689..939089 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; teichoic acid ABC transporter ATP binding protein 939089 tagH 1114545 tagH Lactococcus lactis subsp. lactis Il1403 teichoic acid ABC transporter ATP binding protein NP_267071.1 937689 D 272623 CDS NP_267072.1 15672898 1114546 939089..939898 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; teichoic acid ABC transporter permease 939898 tagG 1114546 tagG Lactococcus lactis subsp. lactis Il1403 teichoic acid ABC transporter permease NP_267072.1 939089 D 272623 CDS NP_267073.1 15672899 1114547 939920..941362 1 NC_002662.1 hypothetical protein 941362 yjeA 1114547 yjeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267073.1 939920 D 272623 CDS NP_267074.1 15672900 1114548 941343..944234 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; teichoic acid biosynthesis protein 944234 tagZ 1114548 tagZ Lactococcus lactis subsp. lactis Il1403 teichoic acid biosynthesis protein NP_267074.1 941343 D 272623 CDS NP_267075.1 15672901 1114549 944247..944801 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; teichoic acid biosynthesis protein 944801 tagY 1114549 tagY Lactococcus lactis subsp. lactis Il1403 teichoic acid biosynthesis protein NP_267075.1 944247 D 272623 CDS NP_267076.1 15672902 1114550 944794..946425 1 NC_002662.1 hypothetical protein 946425 yjeD 1114550 yjeD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267076.1 944794 D 272623 CDS NP_267077.1 15672903 1114551 946470..948893 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; teichoic acid biosynthesis protein 948893 tagX 1114551 tagX Lactococcus lactis subsp. lactis Il1403 teichoic acid biosynthesis protein NP_267077.1 946470 D 272623 CDS NP_267078.1 15672904 1114552 948942..949673 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; lipopolysaccharide biosynthesis protein 949673 yjeF 1114552 yjeF Lactococcus lactis subsp. lactis Il1403 lipopolysaccharide biosynthesis protein NP_267078.1 948942 D 272623 CDS NP_267079.1 15672905 1114553 949844..950833 1 NC_002662.1 hypothetical protein 950833 yjeG 1114553 yjeG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267079.1 949844 D 272623 CDS NP_267080.1 15672906 1114554 950851..951291 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; glycerol-3-phosphate cytidyltransferase 951291 tagD2 1114554 tagD2 Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphate cytidyltransferase NP_267080.1 950851 D 272623 CDS NP_267081.1 15672907 1114555 951328..951759 1 NC_002662.1 hypothetical protein 951759 yjfB 1114555 yjfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267081.1 951328 D 272623 CDS NP_267082.1 15672908 1114556 951780..952967 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; teichoic acid biosynthesis protein F 952967 tagF 1114556 tagF Lactococcus lactis subsp. lactis Il1403 teichoic acid biosynthesis protein F NP_267082.1 951780 D 272623 CDS NP_267083.1 15672909 1114557 952957..954072 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; teichoic acid biosynthesis protein B 954072 tagB 1114557 tagB Lactococcus lactis subsp. lactis Il1403 teichoic acid biosynthesis protein B NP_267083.1 952957 D 272623 CDS NP_267084.1 15672910 1114558 954083..955003 1 NC_002662.1 LytR family; transcriptional regulator 955003 yjfE 1114558 yjfE Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267084.1 954083 D 272623 CDS NP_267085.1 15672911 1114559 955189..956424 1 NC_002662.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 956424 deoB 1114559 deoB Lactococcus lactis subsp. lactis Il1403 phosphopentomutase NP_267085.1 955189 D 272623 CDS NP_267086.1 15672912 1114560 956480..956749 1 NC_002662.1 hypothetical protein 956749 yjfG 1114560 yjfG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267086.1 956480 D 272623 CDS NP_267087.1 15672913 1114561 956820..957524 1 NC_002662.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 957524 deoD 1114561 deoD Lactococcus lactis subsp. lactis Il1403 purine nucleoside phosphorylase NP_267087.1 956820 D 272623 CDS NP_267088.1 15672914 1114562 957642..958589 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983C 958589 tra983C 1114562 tra983C Lactococcus lactis subsp. lactis Il1403 transposase of IS983C NP_267088.1 957642 D 272623 CDS NP_267089.1 15672915 1114563 958745..959191 1 NC_002662.1 hypothetical protein 959191 yjfI 1114563 yjfI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267089.1 958745 D 272623 CDS NP_267090.1 15672916 1114564 959275..959601 1 NC_002662.1 hypothetical protein 959601 yjfJ 1114564 yjfJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267090.1 959275 D 272623 CDS NP_267091.1 15672917 1114565 959757..961424 1 NC_002662.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 961424 fhs 1114565 fhs Lactococcus lactis subsp. lactis Il1403 formate--tetrahydrofolate ligase NP_267091.1 959757 D 272623 CDS NP_267092.1 15672918 1114566 961533..962126 1 NC_002662.1 probably cell wall-associated hydrolase, evidenced by COGnitor; hypothetical protein 962126 yjgB 1114566 yjgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267092.1 961533 D 272623 CDS NP_267093.1 15672919 1114567 962264..963109 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter substrate binding protein 963109 yjgC 1114567 yjgC Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter substrate binding protein NP_267093.1 962264 D 272623 CDS NP_267094.1 15672920 1114568 963377..964264 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter permease 964264 yjgD 1114568 yjgD Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter permease NP_267094.1 963377 D 272623 CDS NP_267095.1 15672921 1114569 964276..965028 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter ATP binding protein 965028 yjgE 1114569 yjgE Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter ATP binding protein NP_267095.1 964276 D 272623 CDS NP_835305.1 30024013 1114570 965033..965257 1 NC_002662.1 hypothetical protein 965257 1114570 L200032 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835305.1 965033 D 272623 CDS NP_267096.1 15672922 1114571 965452..966378 1 NC_002662.1 thioredoxin, glutaredoxin, and glutathione; cofactor FAD flavoprotein; pyridine nucleotide-disulfide oxidoreductase class-II.; thioredoxin reductase 966378 trxB1 1114571 trxB1 Lactococcus lactis subsp. lactis Il1403 thioredoxin reductase NP_267096.1 965452 D 272623 CDS NP_267097.1 15672923 1114572 966520..966768 1 NC_002662.1 protein and peptide secretion; involved in protein export; early event of protein translocation; preprotein translocase subunit SecG 966768 secG 1114572 secG Lactococcus lactis subsp. lactis Il1403 preprotein translocase subunit SecG NP_267097.1 966520 D 272623 CDS NP_267098.1 15672924 1114573 967019..969472 1 NC_002662.1 degradation of RNA; ribonuclease II (RNB) family; ribonuclease 969472 vacB1 1114573 vacB1 Lactococcus lactis subsp. lactis Il1403 ribonuclease NP_267098.1 967019 D 272623 CDS NP_267099.1 15672925 1114574 969491..970078 1 NC_002662.1 probably amidase, evidenced by COGnitor; hypothetical protein 970078 yjgF 1114574 yjgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267099.1 969491 D 272623 CDS NP_267100.1 15672926 1114575 970158..971216 1 NC_002662.1 hypothetical protein 971216 yjhA 1114575 yjhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267100.1 970158 D 272623 CDS NP_267101.1 15672927 1114576 complement(971242..972183) 1 NC_002662.1 similar to 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Bacillus subtilis; hypothetical protein 972183 yjhB 1114576 yjhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267101.1 971242 R 272623 CDS NP_267102.1 15672928 1114577 972337..972600 1 NC_002662.1 ACT domain-containing protein; hypothetical protein 972600 yjhC 1114577 yjhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267102.1 972337 D 272623 CDS NP_267103.1 15672929 1114578 972717..974054 1 NC_002662.1 similar to MJ1665 protein of Methanococcus jannaschii.; hypothetical protein 974054 yjhD 1114578 yjhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267103.1 972717 D 272623 CDS NP_267104.1 15672930 1114579 974154..974633 1 NC_002662.1 hypothetical protein 974633 yjhE 1114579 yjhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267104.1 974154 D 272623 CDS NP_267105.1 15672931 1114580 974701..975396 1 NC_002662.1 glycolysis; phosphoglycerate mutase 975396 yjhF 1114580 yjhF Lactococcus lactis subsp. lactis Il1403 phosphoglycerate mutase NP_267105.1 974701 D 272623 CDS NP_267106.1 15672932 1114581 975393..976139 1 NC_002662.1 murein sacculus and peptidoglycan; in Enterococcus faecalis corresponding enzyme mediates vancomycin resistance; D-alanyl-D-alanine carboxypeptidase 976139 dacB 1114581 dacB Lactococcus lactis subsp. lactis Il1403 D-alanyl-D-alanine carboxypeptidase NP_267106.1 975393 D 272623 CDS NP_267107.1 15672933 1114582 976153..976557 1 NC_002662.1 hypothetical protein 976557 yjhH 1114582 yjhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267107.1 976153 D 272623 CDS NP_267108.1 15672934 1114583 976778..977821 1 NC_002662.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 977821 hrcA 1114583 hrcA Lactococcus lactis subsp. lactis Il1403 heat-inducible transcription repressor NP_267108.1 976778 D 272623 CDS NP_267109.1 15672935 1114584 977851..978390 1 NC_002662.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 978390 grpE 1114584 grpE Lactococcus lactis subsp. lactis Il1403 heat shock protein GrpE NP_267109.1 977851 D 272623 CDS NP_267110.1 15672936 1114585 978463..980286 1 NC_002662.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 980286 dnaK 1114585 dnaK Lactococcus lactis subsp. lactis Il1403 molecular chaperone DnaK NP_267110.1 978463 D 272623 CDS NP_267111.1 15672937 1114586 980498..982261 1 NC_002662.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; myosin-cross-reactive antigen 982261 mycA 1114586 mycA Lactococcus lactis subsp. lactis Il1403 myosin-cross-reactive antigen NP_267111.1 980498 D 272623 CDS NP_267112.1 15672938 1114587 982328..983467 1 NC_002662.1 energy metabolism, amino acids and amines; similar to several hippurate hydrolases and amino acid amidohydrolases; may be a peptidase; amino acid aminohydrolase 983467 yjiB 1114587 yjiB Lactococcus lactis subsp. lactis Il1403 amino acid aminohydrolase NP_267112.1 982328 D 272623 CDS NP_267113.1 15672939 1114588 983589..984290 1 NC_002662.1 evidence experimental PMID:2120234; DeoR-family regulator; repressor of the lactose catabolism operon; galactose 6-phosphate is the inducer; lactose transport regulator 984290 lacR 1114588 lacR Lactococcus lactis subsp. lactis Il1403 lactose transport regulator NP_267113.1 983589 D 272623 CDS NP_267114.1 15672940 1114589 984374..985291 1 NC_002662.1 galactose metabolism; tagatose-6-phosphate kinase 985291 lacC 1114589 lacC Lactococcus lactis subsp. lactis Il1403 tagatose-6-phosphate kinase NP_267114.1 984374 D 272623 CDS NP_267115.2 30024014 1114590 985291..987195 1 NC_002662.1 transport and binding protein; PTS system; PTS system fructose-specific transporter subunit IIBC 987195 fruA 1114590 fruA Lactococcus lactis subsp. lactis Il1403 PTS system fructose-specific transporter subunit IIBC NP_267115.2 985291 D 272623 CDS NP_267116.1 15672942 1114591 987282..988727 1 NC_002662.1 membranes, lipoproteins, and porin; affects resistance to gyrase inhibitor novobiocin; condensationof two molecules of phosphatidylglycerol; cardiolipin synthase 988727 clsA 1114591 clsA Lactococcus lactis subsp. lactis Il1403 cardiolipin synthase NP_267116.1 987282 D 272623 CDS NP_267117.1 15672943 1114592 988807..989694 1 NC_002662.1 similar to YvcJ of Bacillus subtilis; hypothetical protein 989694 yjiE 1114592 yjiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267117.1 988807 D 272623 CDS NP_267118.1 15672944 1114593 989691..990674 1 NC_002662.1 similar to YvcK of Bacillus subtilis; hypothetical protein 990674 yjiF 1114593 yjiF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267118.1 989691 D 272623 CDS NP_267119.1 15672945 1114594 990778..991695 1 NC_002662.1 similar to YvcL of Bacillus subtilis; hypothetical protein 991695 yjjA 1114594 yjjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267119.1 990778 D 272623 CDS NP_267120.1 15672946 1114595 complement(991739..992296) 1 NC_002662.1 similar to tetR-family transcription regulators; transcriptional regulator 992296 yjjB 1114595 yjjB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267120.1 991739 R 272623 CDS NP_267121.1 15672947 1114596 992452..993330 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 993330 yjjC 1114596 yjjC Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267121.1 992452 D 272623 CDS NP_267122.1 15672948 1114597 993341..994963 1 NC_002662.1 transport and binding protein; ABC transporter permease 994963 yjjD 1114597 yjjD Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_267122.1 993341 D 272623 CDS NP_267123.1 15672949 1114598 995105..995476 1 NC_002662.1 hypothetical protein 995476 yjjE 1114598 yjjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267123.1 995105 D 272623 CDS NP_267124.1 15672950 1114599 995620..996414 1 NC_002662.1 transport and binding protein; transporter 996414 yjjF 1114599 yjjF Lactococcus lactis subsp. lactis Il1403 transporter NP_267124.1 995620 D 272623 CDS NP_267125.1 15672951 1114600 complement(996445..996975) 1 NC_002662.1 similar to hypothetical YgaC protein from Bacillus subtilis; hypothetical protein 996975 yjjG 1114600 yjjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267125.1 996445 R 272623 CDS YP_008998701.1 574739639 18245213 complement(997140..997310) 1 NC_002662.1 phosphohydrolase 997310 18245213 L196207a Lactococcus lactis subsp. lactis Il1403 phosphohydrolase YP_008998701.1 997140 R 272623 CDS NP_267126.1 15672952 1114601 complement(997314..998045) 1 NC_002662.1 hypothetical protein 998045 yjjH 1114601 yjjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267126.1 997314 R 272623 CDS NP_267127.1 15672953 1114602 998162..999259 1 NC_002662.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 999259 prfB 1114602 prfB Lactococcus lactis subsp. lactis Il1403 peptide chain release factor 2 NP_267127.1 998162 D 272623 CDS NP_267128.1 15672954 1114603 999586..1000278 1 NC_002662.1 cell division; cell-division ATP-binding protein 1000278 ftsE 1114603 ftsE Lactococcus lactis subsp. lactis Il1403 cell-division ATP-binding protein NP_267128.1 999586 D 272623 CDS NP_267129.1 15672955 1114604 1000271..1001206 1 NC_002662.1 cell division; cell division protein 1001206 ftsX 1114604 ftsX Lactococcus lactis subsp. lactis Il1403 cell division protein NP_267129.1 1000271 D 272623 CDS NP_267130.1 15672956 1114605 complement(1001308..1002285) 1 NC_002662.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1002285 nrdF 1114605 nrdF Lactococcus lactis subsp. lactis Il1403 ribonucleotide-diphosphate reductase subunit beta NP_267130.1 1001308 R 272623 CDS NP_267131.1 15672957 1114606 complement(1002635..1004803) 1 NC_002662.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1004803 nrdE 1114606 nrdE Lactococcus lactis subsp. lactis Il1403 ribonucleotide-diphosphate reductase subunit alpha NP_267131.1 1002635 R 272623 CDS NP_267132.1 15672958 1114607 complement(1004939..1005361) 1 NC_002662.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1005361 nrdI 1114607 nrdI Lactococcus lactis subsp. lactis Il1403 ribonucleotide reductase stimulatory protein NP_267132.1 1004939 R 272623 CDS NP_267133.1 15672959 1114608 complement(1005363..1005539) 1 NC_002662.1 glutaredoxin-like protein; energy metabolism, electron transport; electron transport system for ribonucleotide reductase system NrdEF; NrdH 1005539 ndrH 1114608 ndrH Lactococcus lactis subsp. lactis Il1403 NrdH NP_267133.1 1005363 R 272623 CDS NP_267134.1 15672960 1114609 complement(1005755..1006396) 1 NC_002662.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 1006396 ykaC 1114609 ykaC Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphate acyltransferase PlsY NP_267134.1 1005755 R 272623 CDS NP_267135.1 15672961 1114610 1006671..1008605 1 NC_002662.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1008605 parE 1114610 parE Lactococcus lactis subsp. lactis Il1403 DNA topoisomerase IV subunit B NP_267135.1 1006671 D 272623 CDS NP_267136.1 15672962 1114611 1008810..1009016 1 NC_002662.1 hypothetical protein 1009016 ykaE 1114611 ykaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267136.1 1008810 D 272623 CDS NP_267137.1 15672963 1114612 1009013..1009348 1 NC_002662.1 hypothetical protein 1009348 ykaF 1114612 ykaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267137.1 1009013 D 272623 CDS NP_267138.1 15672964 1114613 1009341..1010174 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; exhibits 3' to 5' exonuclease activity; DNA polymerase III subunit epsilon 1010174 dnaQ 1114613 dnaQ Lactococcus lactis subsp. lactis Il1403 DNA polymerase III subunit epsilon NP_267138.1 1009341 D 272623 CDS NP_267139.1 15672965 1114614 1010171..1010620 1 NC_002662.1 hypothetical protein 1010620 ykbA 1114614 ykbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267139.1 1010171 D 272623 CDS NP_267140.1 15672966 1114615 1010895..1013369 1 NC_002662.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1013369 parC 1114615 parC Lactococcus lactis subsp. lactis Il1403 DNA topoisomerase IV subunit A NP_267140.1 1010895 D 272623 CDS NP_267141.1 15672967 1114616 complement(1013395..1014300) 1 NC_002662.1 hypothetical protein 1014300 ykbB 1114616 ykbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267141.1 1013395 R 272623 CDS NP_267142.1 15672968 1114617 1014515..1017796 1 NC_002662.1 hypothetical protein 1017796 ykbC 1114617 ykbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267142.1 1014515 D 272623 CDS NP_267143.1 15672969 1114618 1017796..1018389 1 NC_002662.1 hypothetical protein 1018389 ykbD 1114618 ykbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267143.1 1017796 D 272623 CDS NP_267144.1 15672970 1114619 1018394..1018945 1 NC_002662.1 hypothetical protein 1018945 ykbE 1114619 ykbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267144.1 1018394 D 272623 CDS NP_267145.1 15672971 1114620 1019058..1019720 1 NC_002662.1 hypothetical protein 1019720 ykbF 1114620 ykbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267145.1 1019058 D 272623 CDS NP_267146.1 15672972 1114621 1019770..1020381 1 NC_002662.1 hypothetical protein 1020381 ykcA 1114621 ykcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267146.1 1019770 D 272623 CDS NP_267147.1 15672973 1114622 1020378..1021055 1 NC_002662.1 hypothetical protein 1021055 ykcB 1114622 ykcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267147.1 1020378 D 272623 CDS NP_267148.1 15672974 1114623 1021071..1021496 1 NC_002662.1 hypothetical protein 1021496 ykcC 1114623 ykcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267148.1 1021071 D 272623 CDS NP_267149.1 15672975 1114624 1022028..1023116 1 NC_002662.1 riboflavin and cobalamin; converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinone 5'-phosphate; riboflavin-specific deaminase 1023116 ribG 1114624 ribG Lactococcus lactis subsp. lactis Il1403 riboflavin-specific deaminase NP_267149.1 1022028 D 272623 CDS NP_267150.1 15672976 1114625 1023116..1023766 1 NC_002662.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1023766 ribB 1114625 ribB Lactococcus lactis subsp. lactis Il1403 riboflavin synthase subunit alpha NP_267150.1 1023116 D 272623 CDS NP_267151.1 15672977 1114626 1023775..1024971 1 NC_002662.1 riboflavin and cobalamin; GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase 1024971 ribA 1114626 ribA Lactococcus lactis subsp. lactis Il1403 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_267151.1 1023775 D 272623 CDS NP_267152.1 15672978 1114627 1024999..1025463 1 NC_002662.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1025463 ribH 1114627 ribH Lactococcus lactis subsp. lactis Il1403 6,7-dimethyl-8-ribityllumazine synthase NP_267152.1 1024999 D 272623 CDS NP_267153.1 15672979 1114628 1025566..1026018 1 NC_002662.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1026018 lspA 1114628 lspA Lactococcus lactis subsp. lactis Il1403 lipoprotein signal peptidase NP_267153.1 1025566 D 272623 CDS NP_267154.1 15672980 1114629 1026079..1026984 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; responsible for synthesis of pseudouridine from uracil-2650 in 23S ribosomal RNA; belongs to family two of pseudouridine synthases; ribosomal large subunit pseudouridine synthase D 1026984 rluD 1114629 rluD Lactococcus lactis subsp. lactis Il1403 ribosomal large subunit pseudouridine synthase D NP_267154.1 1026079 D 272623 CDS NP_267155.1 15672981 1114630 1027131..1027574 1 NC_002662.1 hypothetical protein 1027574 ykcE 1114630 ykcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267155.1 1027131 D 272623 CDS NP_267156.1 15672982 1114631 1027714..1029315 1 NC_002662.1 hypothetical protein 1029315 ykcF 1114631 ykcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267156.1 1027714 D 272623 CDS NP_267157.1 15672983 1114632 1029339..1030295 1 NC_002662.1 hypothetical protein 1030295 ykcG 1114632 ykcG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267157.1 1029339 D 272623 CDS NP_267158.1 15672984 1114633 1030421..1031107 1 NC_002662.1 evidence experimental PMID:10708382; two-component system; involved in phosphatase expression; two-component system regulator 1031107 llrE 1114633 llrE Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267158.1 1030421 D 272623 CDS NP_267159.1 15672985 1114634 1031127..1031642 1 NC_002662.1 hypothetical protein 1031642 ykdA 1114634 ykdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267159.1 1031127 D 272623 CDS NP_267160.1 15672986 1114635 1031646..1032971 1 NC_002662.1 evidence experimental PMID:9172368; two-component systems; sensor protein kinase 1032971 kinE 1114635 kinE Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267160.1 1031646 D 272623 CDS NP_267161.1 15672987 1114636 1032978..1033634 1 NC_002662.1 probably phosphatase, evidenced by COGnitor; hypothetical protein 1033634 ykdB 1114636 ykdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267161.1 1032978 D 272623 CDS NP_267162.1 15672988 1114637 1033815..1035632 1 NC_002662.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1035632 glmS 1114637 glmS Lactococcus lactis subsp. lactis Il1403 glucosamine--fructose-6-phosphate aminotransferase NP_267162.1 1033815 D 272623 CDS NP_267163.1 15672989 1114638 1035763..1036443 1 NC_002662.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1036443 radC 1114638 radC Lactococcus lactis subsp. lactis Il1403 DNA repair protein RadC NP_267163.1 1035763 D 272623 CDS NP_267164.1 15672990 1114639 complement(1036642..1037766) 1 NC_002662.1 prophage pi2 protein 01; similar to integrase of Lactococcus lactis phage BK5-T; integrase 1037766 pi201 1114639 pi201 Lactococcus lactis subsp. lactis Il1403 integrase NP_267164.1 1036642 R 272623 CDS NP_267165.1 15672991 1114640 complement(1037889..1038434) 1 NC_002662.1 similar to Orf3 of bacteriophage TP901-1; prophage pi2 protein 02 1038434 pi202 1114640 pi202 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 02 NP_267165.1 1037889 R 272623 CDS NP_267166.1 15672992 1114641 complement(1038491..1038928) 1 NC_002662.1 similar to Orf2 of bacteriophage TP901-1; prophage pi2 protein 03 1038928 pi203 1114641 pi203 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 03 NP_267166.1 1038491 R 272623 CDS NP_267167.1 15672993 1114642 complement(1038925..1039467) 1 NC_002662.1 prophage pi2 protein 04; similar to Orf4 of bacteriophage TP901-1; cI-like repressor 1039467 pi204 1114642 pi204 Lactococcus lactis subsp. lactis Il1403 cI-like repressor NP_267167.1 1038925 R 272623 CDS NP_267168.1 15672994 1114643 1039635..1039853 1 NC_002662.1 similar to Orf5 of bacteriophage TP901-1; prophage pi2 protein 05 1039853 pi205 1114643 pi205 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 05 NP_267168.1 1039635 D 272623 CDS NP_267169.1 15672995 1114644 1039890..1040633 1 NC_002662.1 similar to Orf6 of bacteriophage TP901-1; prophage pi2 protein 06 1040633 pi206 1114644 pi206 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 06 NP_267169.1 1039890 D 272623 CDS NP_267170.1 15672996 1114645 1040646..1040981 1 NC_002662.1 similar to Orf111 of bacteriophage BK5-T; prophage pi2 protein 07 1040981 pi207 1114645 pi207 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 07 NP_267170.1 1040646 D 272623 CDS NP_835341.1 30024015 1114646 1041119..1041313 1 NC_002662.1 similar to prophage pi3 protein 53; hypothetical protein 1041313 1114646 L200033 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835341.1 1041119 D 272623 CDS NP_267171.1 15672997 1114647 complement(1041310..1041585) 1 NC_002662.1 similar to Orf10 of bacteriophage Tuc2009; prophage pi2 protein 08 1041585 pi208 1114647 pi208 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 08 NP_267171.1 1041310 R 272623 CDS NP_267172.1 15672998 1114648 1041688..1041903 1 NC_002662.1 similar to Orf71 of bacteriophage phi31; prophage pi2 protein 09 1041903 pi209 1114648 pi209 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 09 NP_267172.1 1041688 D 272623 CDS NP_267173.1 15672999 1114649 1042019..1042537 1 NC_002662.1 similar to Orf13 of bacteriophage Tuc2009; prophage pi2 protein 10 1042537 pi210 1114649 pi210 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 10 NP_267173.1 1042019 D 272623 CDS NP_267174.1 15673000 1114650 1042546..1043169 1 NC_002662.1 prophage pi2 protein 11; similar to topoisomerase I of bacteriophage Tuc2009; topoisomerase 1043169 pi211 1114650 pi211 Lactococcus lactis subsp. lactis Il1403 topoisomerase NP_267174.1 1042546 D 272623 CDS NP_267175.1 15673001 1114651 1043169..1043621 1 NC_002662.1 prophage pi2 protein 12; single strand binding protein 1043621 pi212 1114651 pi212 Lactococcus lactis subsp. lactis Il1403 single strand binding protein NP_267175.1 1043169 D 272623 CDS NP_267176.1 15673002 1114652 1043761..1044528 1 NC_002662.1 prophage pi2 protein 13; similar to Rep2009 of bacteriophage Tuc2009; replisome organizer 1044528 pi213 1114652 pi213 Lactococcus lactis subsp. lactis Il1403 replisome organizer NP_267176.1 1043761 D 272623 CDS NP_267177.1 15673003 1114653 1044528..1045253 1 NC_002662.1 similar to Orf17 of bacteriophage Tuc2009; hypothetical protein 1045253 pi214 1114653 pi214 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267177.1 1044528 D 272623 CDS NP_267178.1 15673004 1114654 1045250..1045639 1 NC_002662.1 similar to Orf19 of bacteriophage Tuc2009; prophage pi2 protein 15 1045639 pi215 1114654 pi215 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 15 NP_267178.1 1045250 D 272623 CDS NP_267179.1 15673005 1114655 1045642..1045836 1 NC_002662.1 similar to Orf15 of bacteriophage r1t; prophage pi2 protein 16 1045836 pi216 1114655 pi216 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 16 NP_267179.1 1045642 D 272623 CDS NP_835306.1 30024016 1114656 1045817..1046068 1 NC_002662.1 similar to prophage pi3 protein 43; hypothetical protein 1046068 1114656 L200034 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835306.1 1045817 D 272623 CDS NP_267180.1 15673006 1114657 1046180..1046446 1 NC_002662.1 prophage pi2 protein 17 1046446 pi217 1114657 pi217 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 17 NP_267180.1 1046180 D 272623 CDS NP_835342.1 30024017 1114658 1046468..1046647 1 NC_002662.1 similar to prophage pi3 protein 41; hypothetical protein 1046647 1114658 L200035 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835342.1 1046468 D 272623 CDS NP_267181.1 15673007 1114659 1046637..1047206 1 NC_002662.1 similar to Orf22 of bacteriophage Tuc2009; prophage pi2 protein 18 1047206 pi218 1114659 pi218 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 18 NP_267181.1 1046637 D 272623 CDS NP_835343.1 30024018 1114660 1047400..1047606 1 NC_002662.1 similar to prophage pi1 protein 17; hypothetical protein 1047606 1114660 L200036 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835343.1 1047400 D 272623 CDS NP_267182.1 15673008 1114661 1047599..1047871 1 NC_002662.1 prophage pi2 protein 19 1047871 pi219 1114661 pi219 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 19 NP_267182.1 1047599 D 272623 CDS NP_267183.1 15673009 1114662 1047868..1048422 1 NC_002662.1 similar to Orf24 of bacteriophage Tuc2009; prophage pi2 protein 20 1048422 pi220 1114662 pi220 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 20 NP_267183.1 1047868 D 272623 CDS NP_267184.1 15673010 1114663 1048419..1048838 1 NC_002662.1 prophage pi2 protein 21; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t; deoxyuridine 5'-triphosphate nucleotidohydrolase 1048838 pi221 1114663 pi221 Lactococcus lactis subsp. lactis Il1403 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_267184.1 1048419 D 272623 CDS NP_267185.1 15673011 1114664 1048841..1049338 1 NC_002662.1 prophage pi2 protein 22 1049338 pi222 1114664 pi222 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 22 NP_267185.1 1048841 D 272623 CDS NP_267186.1 15673012 1114665 1049328..1049675 1 NC_002662.1 prophage pi2 protein 23 1049675 pi223 1114665 pi223 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 23 NP_267186.1 1049328 D 272623 CDS NP_835307.1 30024019 1114666 1049697..1049861 1 NC_002662.1 similar to bacteriophage bIL285 Orf31; hypothetical protein 1049861 1114666 L200037 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835307.1 1049697 D 272623 CDS NP_835308.1 30024020 1114667 1049908..1050093 1 NC_002662.1 similar to bacteriophage bIL285 Orf32; hypothetical protein 1050093 1114667 L200038 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835308.1 1049908 D 272623 CDS NP_835309.1 30024021 1114668 1050135..1050308 1 NC_002662.1 similar to bacteriophage bIL285 Orf33; hypothetical protein 1050308 1114668 L200039 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835309.1 1050135 D 272623 CDS NP_267187.1 15673013 1114669 1050309..1050608 1 NC_002662.1 prophage pi2 protein 24 1050608 pi224 1114669 pi224 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 24 NP_267187.1 1050309 D 272623 CDS NP_835310.1 30024022 1114670 1050605..1050787 1 NC_002662.1 similar to bacteriophage bIL285 Orf35; hypothetical protein 1050787 1114670 L200040 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835310.1 1050605 D 272623 CDS NP_267188.1 15673014 1114671 complement(1050725..1050988) 1 NC_002662.1 prophage pi2 protein 25 1050988 pi225 1114671 pi225 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 25 NP_267188.1 1050725 R 272623 CDS NP_267189.1 15673015 1114672 1051151..1051444 1 NC_002662.1 similar to Lactococcus lactis S114 hypothetical protein accession number Y11901; prophage pi2 protein 26 1051444 pi226 1114672 pi226 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 26 NP_267189.1 1051151 D 272623 CDS NP_267190.1 15673016 1114673 1051522..1051923 1 NC_002662.1 prophage pi2 protein 27 1051923 pi227 1114673 pi227 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 27 NP_267190.1 1051522 D 272623 CDS NP_267191.2 574739633 1114674 1052187..1052486 1 NC_002662.1 HNH endonuclease 1052486 pi228 1114674 pi228 Lactococcus lactis subsp. lactis Il1403 HNH endonuclease NP_267191.2 1052187 D 272623 CDS NP_267192.1 15673018 1114675 1052578..1052946 1 NC_002662.1 prophage pi2 protein 29 1052946 pi229 1114675 pi229 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 29 NP_267192.1 1052578 D 272623 CDS NP_267193.1 15673019 1114676 1052930..1054708 1 NC_002662.1 prophage pi2 protein 30; similar to Orf22 of bacteriophage phi-105; terminase 1054708 pi230 1114676 pi230 Lactococcus lactis subsp. lactis Il1403 terminase NP_267193.1 1052930 D 272623 CDS NP_267194.1 15673020 1114677 1054722..1055927 1 NC_002662.1 prophage pi2 protein 31 1055927 pi231 1114677 pi231 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 31 NP_267194.1 1054722 D 272623 CDS NP_267195.1 15673021 1114678 1055942..1056538 1 NC_002662.1 similar to Orf26 of bacteriophage phi-105; prophage pi2 protein 32 1056538 pi232 1114678 pi232 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 32 NP_267195.1 1055942 D 272623 CDS NP_267196.1 15673022 1114679 1056510..1057703 1 NC_002662.1 prophage pi2 protein 33; similar to capsid protein of S.aureus bacteriophage phi PVL; capsid protein 1057703 pi233 1114679 pi233 Lactococcus lactis subsp. lactis Il1403 capsid protein NP_267196.1 1056510 D 272623 CDS NP_267197.1 15673023 1114680 1057758..1058615 1 NC_002662.1 prophage pi2 protein 34 1058615 pi234 1114680 pi234 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 34 NP_267197.1 1057758 D 272623 CDS NP_267198.1 15673024 1114681 1058608..1058889 1 NC_002662.1 prophage pi2 protein 35 1058889 pi235 1114681 pi235 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 35 NP_267198.1 1058608 D 272623 CDS NP_267199.1 15673025 1114682 1058876..1059193 1 NC_002662.1 prophage pi2 protein 36 1059193 pi236 1114682 pi236 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 36 NP_267199.1 1058876 D 272623 CDS NP_267200.1 15673026 1114683 1059183..1059554 1 NC_002662.1 prophage pi2 protein 37 1059554 pi237 1114683 pi237 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 37 NP_267200.1 1059183 D 272623 CDS NP_267201.1 15673027 1114684 1059551..1059868 1 NC_002662.1 prophage pi2 protein 38 1059868 pi238 1114684 pi238 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 38 NP_267201.1 1059551 D 272623 CDS NP_267202.1 15673028 1114685 1059886..1060494 1 NC_002662.1 similar to Orf34 of Bacillus subtilis bacteriophage phi-105; prophage pi2 protein 39 1060494 pi239 1114685 pi239 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 39 NP_267202.1 1059886 D 272623 CDS NP_267203.1 15673029 1114686 1060504..1060863 1 NC_002662.1 prophage pi2 protein 40 1060863 pi240 1114686 pi240 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 40 NP_267203.1 1060504 D 272623 CDS NP_267204.1 15673030 1114687 1060890..1061066 1 NC_002662.1 prophage pi2 protein 41 1061066 pi241 1114687 pi241 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 41 NP_267204.1 1060890 D 272623 CDS NP_267205.1 15673031 1114688 1061080..1063341 1 NC_002662.1 similar to protein l16 of bacteriophage bil170; prophage pi2 protein 42 1063341 pi242 1114688 pi242 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 42 NP_267205.1 1061080 D 272623 CDS NP_267206.1 15673032 1114689 1063342..1064091 1 NC_002662.1 similar to Orf247 of Lactobacillus gasseri bacteriophage phi adh; prophage pi2 protein 43 1064091 pi243 1114689 pi243 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 43 NP_267206.1 1063342 D 272623 CDS NP_267207.1 15673033 1114690 1064088..1066772 1 NC_002662.1 similar to a part of hypothetical protein BB0262 of Borrelia burgdorferi; prophage pi2 protein 44 1066772 pi244 1114690 pi244 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 44 NP_267207.1 1064088 D 272623 CDS NP_267208.1 15673034 1114691 1066785..1068386 1 NC_002662.1 prophage pi2 protein 45 1068386 pi245 1114691 pi245 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 45 NP_267208.1 1066785 D 272623 CDS NP_267209.1 15673035 1114692 1068379..1069209 1 NC_002662.1 prophage pi2 protein 46 1069209 pi246 1114692 pi246 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 46 NP_267209.1 1068379 D 272623 CDS NP_267210.1 15673036 1114693 1069268..1069675 1 NC_002662.1 prophage pi2 protein 47 1069675 pi247 1114693 pi247 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 47 NP_267210.1 1069268 D 272623 CDS NP_267211.1 15673037 1114694 1069662..1070000 1 NC_002662.1 prophage pi2 protein 48 1070000 pi248 1114694 pi248 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 48 NP_267211.1 1069662 D 272623 CDS NP_267212.1 15673038 1114695 1070002..1070229 1 NC_002662.1 prophage pi2 protein 49 1070229 pi249 1114695 pi249 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 49 NP_267212.1 1070002 D 272623 CDS NP_267213.1 15673039 1114696 1070255..1070479 1 NC_002662.1 similar to Orf75 of Lactococcus lactis phage BK5-T; prophage pi2 protein 50 1070479 pi250 1114696 pi250 Lactococcus lactis subsp. lactis Il1403 prophage pi2 protein 50 NP_267213.1 1070255 D 272623 CDS NP_267216.1 15673042 1114699 complement(1072170..1072709) 1 NC_002662.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 1072709 ykhD 1114699 ykhD Lactococcus lactis subsp. lactis Il1403 redox-sensing transcriptional repressor Rex NP_267216.1 1072170 R 272623 CDS NP_267217.1 15673043 1114700 1072934..1073326 1 NC_002662.1 hypothetical protein 1073326 ykhE 1114700 ykhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267217.1 1072934 D 272623 CDS NP_267218.1 15673044 1114701 1073504..1075411 1 NC_002662.1 transport and binding protein. contains two ATP binding domains; ABC transporter ATP-binding protein 1075411 ykhF 1114701 ykhF Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267218.1 1073504 D 272623 CDS NP_267219.1 15673045 1114702 1075600..1076400 1 NC_002662.1 hypothetical protein 1076400 ykhG 1114702 ykhG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267219.1 1075600 D 272623 CDS NP_267220.1 15673046 1114703 1076402..1076767 1 NC_002662.1 hypothetical protein 1076767 ykhH 1114703 ykhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267220.1 1076402 D 272623 CDS NP_267221.1 15673047 1114704 complement(1077255..1077581) 1 NC_002662.1 hypothetical protein 1077581 ykhJ 1114704 ykhJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267221.1 1077255 R 272623 CDS NP_835311.1 30024023 1114705 1077283..1077468 1 NC_002662.1 hypothetical protein 1077468 1114705 L200041 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835311.1 1077283 D 272623 CDS NP_267222.1 15673048 1114706 1077643..1078500 1 NC_002662.1 similar to positive regulator GadR of Lactococcus lactis; transcriptional regulator 1078500 ykhI 1114706 ykhI Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267222.1 1077643 D 272623 CDS NP_267223.1 15673049 1114707 1078747..1079478 1 NC_002662.1 hypothetical protein 1079478 ykhK 1114707 ykhK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267223.1 1078747 D 272623 CDS NP_267224.1 15673050 1114708 1080700..1081329 1 NC_002662.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1081329 pyrE 1114708 pyrE Lactococcus lactis subsp. lactis Il1403 orotate phosphoribosyltransferase NP_267224.1 1080700 D 272623 CDS NP_267225.1 15673051 1114709 1081430..1082755 1 NC_002662.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1082755 pyrC 1114709 pyrC Lactococcus lactis subsp. lactis Il1403 dihydroorotase NP_267225.1 1081430 D 272623 CDS NP_267226.1 15673052 1114710 1083162..1083830 1 NC_002662.1 component of primosome; hypothetical protein 1083830 dnaD 1114710 dnaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267226.1 1083162 D 272623 CDS NP_267227.1 15673053 1114711 1083852..1084508 1 NC_002662.1 degradation of DNA; endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate; endonuclease III 1084508 nth 1114711 nth Lactococcus lactis subsp. lactis Il1403 endonuclease III NP_267227.1 1083852 D 272623 CDS NP_267228.1 15673054 1114712 1084501..1085193 1 NC_002662.1 hypothetical protein 1085193 ykiC 1114712 ykiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267228.1 1084501 D 272623 CDS NP_267229.1 15673055 1114713 1085190..1085963 1 NC_002662.1 hypothetical protein 1085963 ykiD 1114713 ykiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267229.1 1085190 D 272623 CDS NP_267230.1 15673056 1114714 complement(1086002..1086367) 1 NC_002662.1 hypothetical protein 1086367 ykiE 1114714 ykiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267230.1 1086002 R 272623 CDS NP_267231.1 15673057 1114715 complement(1086489..1087304) 1 NC_002662.1 hypothetical protein 1087304 ykiF 1114715 ykiF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267231.1 1086489 R 272623 CDS NP_267232.1 15673058 1114716 complement(1087351..1088712) 1 NC_002662.1 hypothetical protein 1088712 ykiG 1114716 ykiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267232.1 1087351 R 272623 CDS NP_267233.1 15673059 1114717 1088881..1089288 1 NC_002662.1 hypothetical protein 1089288 ykiH 1114717 ykiH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267233.1 1088881 D 272623 CDS NP_267234.1 15673060 1114718 1089281..1090456 1 NC_002662.1 hypothetical protein 1090456 ykiI 1114718 ykiI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267234.1 1089281 D 272623 CDS NP_267235.1 15673061 1114719 1090626..1090940 1 NC_002662.1 ribosomal proteins; synthesis and modification; binds 23S rRNA in presence of protein L20; L21P family of ribosomal proteins; 50S ribosomal protein L21 1090940 rplU 1114719 rplU Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L21 NP_267235.1 1090626 D 272623 CDS NP_267236.1 15673062 1114720 1090943..1091278 1 NC_002662.1 hypothetical protein 1091278 ykjA 1114720 ykjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267236.1 1090943 D 272623 CDS NP_267237.1 15673063 1114721 1091280..1091564 1 NC_002662.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1091564 rpmA 1114721 rpmA Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L27 NP_267237.1 1091280 D 272623 CDS NP_267240.1 15673066 1114724 1093130..1094098 1 NC_002662.1 adaptations and atypical conditions; phosphate starvation inducible protein 1094098 phoL 1114724 phoL Lactococcus lactis subsp. lactis Il1403 phosphate starvation inducible protein NP_267240.1 1093130 D 272623 CDS NP_267241.1 15673067 1114725 1094156..1094635 1 NC_002662.1 probably ADP-ribose pyrophosphatase or mutT, evidenced by COGnitor; hypothetical protein 1094635 ykjE 1114725 ykjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267241.1 1094156 D 272623 CDS NP_267242.1 15673068 1114726 1094787..1095275 1 NC_002662.1 metalloprotease 1095275 ykjF 1114726 ykjF Lactococcus lactis subsp. lactis Il1403 metalloprotease NP_267242.1 1094787 D 272623 CDS NP_267243.1 15673069 1114727 1095259..1095714 1 NC_002662.1 diacylglycerol kinase 1095714 dgkA 1114727 dgkA Lactococcus lactis subsp. lactis Il1403 diacylglycerol kinase NP_267243.1 1095259 D 272623 CDS NP_267244.1 15673070 1114728 1095728..1096306 1 NC_002662.1 hypothetical protein 1096306 ykjH 1114728 ykjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267244.1 1095728 D 272623 CDS NP_267245.1 15673071 1114729 complement(1096340..1096990) 1 NC_002662.1 competence protein; transformation; ATP-dependent RNA/DNA helicase involved in DNA transport; hypothetical protein 1096990 comFC 1114729 comFC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267245.1 1096340 R 272623 CDS NP_267246.1 15673072 1114730 complement(1096987..1098309) 1 NC_002662.1 competence protein; transformation; ATP-dependent RNA/DNA helicase involved in DNA transport; protein ComFA 1098309 comFA 1114730 comFA Lactococcus lactis subsp. lactis Il1403 protein ComFA NP_267246.1 1096987 R 272623 CDS NP_267247.1 15673073 1114731 1098366..1098995 1 NC_002662.1 hypothetical protein 1098995 ykjI 1114731 ykjI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267247.1 1098366 D 272623 CDS NP_267248.1 15673074 1114732 1099129..1099626 1 NC_002662.1 similar to teicoplanin resistance protein of transposon Tn1546 of Enterococcus faecium; hypothetical protein 1099626 ykjJ 1114732 ykjJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267248.1 1099129 D 272623 CDS NP_267249.1 15673075 1114733 1099674..1100693 1 NC_002662.1 integral membrane protein; hypothetical protein 1100693 ykjK 1114733 ykjK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267249.1 1099674 D 272623 CDS NP_267250.1 15673076 1114734 1100803..1101555 1 NC_002662.1 nucleotide and nucleoside interconversions; nucleotidase 1101555 nucA 1114734 nucA Lactococcus lactis subsp. lactis Il1403 nucleotidase NP_267250.1 1100803 D 272623 CDS NP_267251.1 15673077 1114735 1101840..1102793 1 NC_002662.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1102793 glyQ 1114735 glyQ Lactococcus lactis subsp. lactis Il1403 glycyl-tRNA synthetase subunit alpha NP_267251.1 1101840 D 272623 CDS NP_267252.1 15673078 1114736 1102793..1104814 1 NC_002662.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1104814 glyS 1114736 glyS Lactococcus lactis subsp. lactis Il1403 glycyl-tRNA synthetase subunit beta NP_267252.1 1102793 D 272623 CDS NP_267253.1 15673079 1114737 1104925..1105167 1 NC_002662.1 hypothetical protein 1105167 ylaC 1114737 ylaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267253.1 1104925 D 272623 CDS NP_267254.1 15673080 1114738 1105378..1106589 1 NC_002662.1 hypothetical protein 1106589 ylaD 1114738 ylaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267254.1 1105378 D 272623 CDS NP_267255.1 15673081 1114739 complement(1106612..1107199) 1 NC_002662.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1107199 nadD 1114739 nadD Lactococcus lactis subsp. lactis Il1403 nicotinic acid mononucleotide adenylyltransferase NP_267255.1 1106612 R 272623 CDS NP_267256.1 15673082 1114740 1107724..1109211 1 NC_002662.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1109211 ylaF 1114740 ylaF Lactococcus lactis subsp. lactis Il1403 nicotinate phosphoribosyltransferase NP_267256.1 1107724 D 272623 CDS NP_267257.1 15673083 1114741 1109208..1109696 1 NC_002662.1 hypothetical protein 1109696 ylaG 1114741 ylaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267257.1 1109208 D 272623 CDS NP_267258.1 15673084 1114742 1109757..1110581 1 NC_002662.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1110581 nadE 1114742 nadE Lactococcus lactis subsp. lactis Il1403 NAD synthetase NP_267258.1 1109757 D 272623 CDS NP_267259.1 15673085 1114743 1110709..1111410 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 1111410 ylbA 1114743 ylbA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267259.1 1110709 D 272623 CDS NP_267260.1 15673086 1114744 1111404..1114094 1 NC_002662.1 transport and binding protein; ABC transporter permease 1114094 ylbB 1114744 ylbB Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_267260.1 1111404 D 272623 CDS NP_267261.1 15673087 1114745 complement(1114170..1114955) 1 NC_002662.1 riboflavin and cobalamin; similar to cobyric acid synthase CobQ of Heliobacillus mobilis, cobalamin biosynthesis pathway; cobyric acid synthase 1114955 cobQ 1114745 cobQ Lactococcus lactis subsp. lactis Il1403 cobyric acid synthase NP_267261.1 1114170 R 272623 CDS NP_267262.1 15673088 1114746 complement(1114956..1116305) 1 NC_002662.1 similar to UDP-N-acetylmuramyl tripeptide synthetase MurC of Heliobacillus mobilis; hypothetical protein 1116305 ylbD 1114746 ylbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267262.1 1114956 R 272623 CDS NP_267263.1 15673089 1114747 1116416..1117081 1 NC_002662.1 fermentation; converts acetolactate into actoin or diacetyl; alpha-acetolactate decarboxylase 1117081 aldC 1114747 aldC Lactococcus lactis subsp. lactis Il1403 alpha-acetolactate decarboxylase NP_267263.1 1116416 D 272623 CDS NP_267264.1 15673090 1114748 1117368..1119191 1 NC_002662.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1119191 lepA 1114748 lepA Lactococcus lactis subsp. lactis Il1403 GTP-binding protein LepA NP_267264.1 1117368 D 272623 CDS NP_267265.1 15673091 1114749 1119258..1119893 1 NC_002662.1 anaerobic energy metabolism; similar to YhfK of Bacillus subtilis and to several hypothetical proteins; oxidoreductase 1119893 ylbE 1114749 ylbE Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267265.1 1119258 D 272623 CDS NP_267266.1 15673092 1114750 1120067..1121533 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid permease 1121533 ylcA 1114750 ylcA Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_267266.1 1120067 D 272623 CDS NP_267267.1 15673093 1114751 1121779..1124268 1 NC_002662.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1124268 gyrA 1114751 gyrA Lactococcus lactis subsp. lactis Il1403 DNA gyrase subunit A NP_267267.1 1121779 D 272623 CDS NP_267268.1 15673094 1114752 1124352..1125437 1 NC_002662.1 thiamine biosynthesis lipoprotein 1125437 apbE 1114752 apbE Lactococcus lactis subsp. lactis Il1403 thiamine biosynthesis lipoprotein NP_267268.1 1124352 D 272623 CDS NP_267269.1 15673095 1114753 1125438..1126301 1 NC_002662.1 probably an integral membrane protein; hypothetical protein 1126301 ylcC 1114753 ylcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267269.1 1125438 D 272623 CDS NP_267270.1 15673096 1114754 1126413..1127852 1 NC_002662.1 hypothetical protein 1127852 ylcD 1114754 ylcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267270.1 1126413 D 272623 CDS NP_267271.1 15673097 1114755 1127867..1128148 1 NC_002662.1 hypothetical protein 1128148 ylcE 1114755 ylcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267271.1 1127867 D 272623 CDS NP_267272.1 15673098 1114756 1128168..1129412 1 NC_002662.1 hypothetical protein 1129412 ylcF 1114756 ylcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267272.1 1128168 D 272623 CDS NP_267273.1 15673099 1114757 1129534..1132299 1 NC_002662.1 probably an integral membrane protein; C-part similar to lysyl tRNA synthetase; hypothetical protein 1132299 ylcG 1114757 ylcG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267273.1 1129534 D 272623 CDS NP_267274.1 15673100 1114758 1132286..1132915 1 NC_002662.1 hypothetical protein 1132915 yldA 1114758 yldA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267274.1 1132286 D 272623 CDS NP_267275.1 15673101 1114759 complement(1132860..1133636) 1 NC_002662.1 hypothetical protein 1133636 yldB 1114759 yldB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267275.1 1132860 R 272623 CDS NP_267276.1 15673102 1114760 1133793..1136069 1 NC_002662.1 UvrD subfamily of helicases; ATP-dependent helicase PcrA 1136069 pcrA 1114760 pcrA Lactococcus lactis subsp. lactis Il1403 ATP-dependent helicase PcrA NP_267276.1 1133793 D 272623 CDS NP_267277.1 15673103 1114761 1136089..1136556 1 NC_002662.1 MutT; mutator protein 1136556 mutX 1114761 mutX Lactococcus lactis subsp. lactis Il1403 mutator protein NP_267277.1 1136089 D 272623 CDS NP_267278.1 15673104 1114762 1136602..1137174 1 NC_002662.1 hydrolysis of the deoxyribose N-glycosidc bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions; DNA-3-methyladenine glycosidase I 1137174 tag 1114762 tag Lactococcus lactis subsp. lactis Il1403 DNA-3-methyladenine glycosidase I NP_267278.1 1136602 D 272623 CDS NP_267279.1 15673105 1114763 1137252..1137710 1 NC_002662.1 hypothetical protein 1137710 yldC 1114763 yldC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267279.1 1137252 D 272623 CDS NP_267280.1 15673106 1114764 1137875..1139383 1 NC_002662.1 Reduces fumarate to succinate in anaerobic bacterial respiration; fumarate reductase flavoprotein subunit 1139383 frdC 1114764 frdC Lactococcus lactis subsp. lactis Il1403 fumarate reductase flavoprotein subunit NP_267280.1 1137875 D 272623 CDS NP_267281.1 15673107 1114765 1139554..1140246 1 NC_002662.1 hypothetical protein 1140246 yldE 1114765 yldE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267281.1 1139554 D 272623 CDS NP_267282.1 15673108 1114766 1140387..1141376 1 NC_002662.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1141376 truB 1114766 truB Lactococcus lactis subsp. lactis Il1403 tRNA pseudouridine synthase B NP_267282.1 1140387 D 272623 CDS NP_267283.1 15673109 1114767 1141407..1142309 1 NC_002662.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1142309 ribC 1114767 ribC Lactococcus lactis subsp. lactis Il1403 bifunctional riboflavin kinase/FMN adenylyltransferase NP_267283.1 1141407 D 272623 CDS NP_267284.1 15673110 1114768 1142407..1143378 1 NC_002662.1 glycolysis; L-lactate dehydrogenase 1143378 ldhX 1114768 ldhX Lactococcus lactis subsp. lactis Il1403 L-lactate dehydrogenase NP_267284.1 1142407 D 272623 CDS NP_267285.1 15673111 1114769 1143537..1144598 1 NC_002662.1 surface protein; hypothetical protein 1144598 yleB 1114769 yleB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267285.1 1143537 D 272623 CDS NP_267286.1 15673112 1114770 1144591..1145484 1 NC_002662.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 1145484 murQ 1114770 murQ Lactococcus lactis subsp. lactis Il1403 N-acetylmuramic acid 6-phosphate etherase NP_267286.1 1144591 D 272623 CDS NP_267287.1 15673113 1114771 1145519..1146883 1 NC_002662.1 transport and binding protein; PTS system; PTS system sucrose-specific transporter subunit IIBC 1146883 yleD 1114771 yleD Lactococcus lactis subsp. lactis Il1403 PTS system sucrose-specific transporter subunit IIBC NP_267287.1 1145519 D 272623 CDS NP_267288.1 15673114 1114772 1146884..1147471 1 NC_002662.1 transport and binding protein; PTS system; similar to beta-glucoside-specific PTS system IIABC component; hypothetical protein 1147471 yleE 1114772 yleE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267288.1 1146884 D 272623 CDS NP_267289.1 15673115 1114773 1147533..1148384 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 1148384 yleF 1114773 yleF Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267289.1 1147533 D 272623 CDS NP_267290.1 15673116 1114774 1148515..1149273 1 NC_002662.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1149273 tpiA 1114774 tpiA Lactococcus lactis subsp. lactis Il1403 triosephosphate isomerase NP_267290.1 1148515 D 272623 CDS NP_267291.1 15673117 1114775 1149436..1150407 1 NC_002662.1 drug and analog sensitivity; penicillin acylase 1150407 pacA 1114775 pacA Lactococcus lactis subsp. lactis Il1403 penicillin acylase NP_267291.1 1149436 D 272623 CDS NP_267292.1 15673118 1114776 1150456..1151043 1 NC_002662.1 hypothetical protein 1151043 ylfA 1114776 ylfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267292.1 1150456 D 272623 CDS NP_267293.1 15673119 1114777 1151258..1152595 1 NC_002662.1 hypothetical protein 1152595 ylfB 1114777 ylfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267293.1 1151258 D 272623 CDS NP_267294.1 15673120 1114778 1152577..1153104 1 NC_002662.1 hypothetical protein 1153104 ylfC 1114778 ylfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267294.1 1152577 D 272623 CDS NP_267295.1 15673121 1114779 1153284..1154423 1 NC_002662.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1154423 hemN 1114779 hemN Lactococcus lactis subsp. lactis Il1403 coproporphyrinogen III oxidase NP_267295.1 1153284 D 272623 CDS NP_267296.1 15673122 1114780 1154470..1155285 1 NC_002662.1 hypothetical protein 1155285 ylfD 1114780 ylfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267296.1 1154470 D 272623 CDS NP_267297.1 15673123 1114781 1155388..1155831 1 NC_002662.1 2'-deoxyribonucleotide metabolism; dCMP deaminase 1155831 dcdA 1114781 dcdA Lactococcus lactis subsp. lactis Il1403 dCMP deaminase NP_267297.1 1155388 D 272623 CDS NP_267299.1 15673125 1114784 1156705..1157478 1 NC_002662.1 amino sugars; N-acetylglucosamine catabolic protein 1157478 ylfH 1114784 ylfH Lactococcus lactis subsp. lactis Il1403 N-acetylglucosamine catabolic protein NP_267299.1 1156705 D 272623 CDS NP_267300.1 15673126 1114785 1157581..1158198 1 NC_002662.1 hypothetical protein 1158198 ylfI 1114785 ylfI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267300.1 1157581 D 272623 CDS NP_267301.1 15673127 1114786 1158457..1159446 1 NC_002662.1 purine ribonucleotide biosynthesis; similar also to inosine-5'-monophosphate dehydrogenases; maintains the intracellular balance of A and G nucleotides; guanosine 5'-monophosphate oxidoreductase 1159446 guaC 1114786 guaC Lactococcus lactis subsp. lactis Il1403 guanosine 5'-monophosphate oxidoreductase NP_267301.1 1158457 D 272623 CDS NP_267302.1 15673128 1114787 1159718..1160311 1 NC_002662.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1160311 xpt 1114787 xpt Lactococcus lactis subsp. lactis Il1403 xanthine phosphoribosyltransferase NP_267302.1 1159718 D 272623 CDS NP_267303.1 15673129 1114788 1160360..1161664 1 NC_002662.1 transport and binding protein; nucleosides, purines and pyrimidines; xanthine/uracil permease 1161664 pbuX 1114788 pbuX Lactococcus lactis subsp. lactis Il1403 xanthine/uracil permease NP_267303.1 1160360 D 272623 CDS NP_267304.1 15673130 1114789 complement(1161693..1162106) 1 NC_002662.1 hypothetical protein 1162106 ylgB 1114789 ylgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267304.1 1161693 R 272623 CDS NP_267305.1 15673131 1114790 complement(1162226..1162735) 1 NC_002662.1 hypothetical protein 1162735 ylgC 1114790 ylgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267305.1 1162226 R 272623 CDS NP_267306.1 15673132 1114791 1163134..1163640 1 NC_002662.1 evidence experimental PMID:7574597; folic acid; dihydropholate reductase 1163640 dfrA 1114791 dfrA Lactococcus lactis subsp. lactis Il1403 dihydropholate reductase NP_267306.1 1163134 D 272623 CDS NP_835313.1 30024025 1114792 1163637..1163807 1 NC_002662.1 hypothetical protein 1163807 1114792 L200043 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835313.1 1163637 D 272623 CDS NP_267307.1 15673133 1114793 1163884..1165119 1 NC_002662.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1165119 clpX 1114793 clpX Lactococcus lactis subsp. lactis Il1403 ATP-dependent protease ATP-binding subunit ClpX NP_267307.1 1163884 D 272623 CDS NP_267308.1 15673134 1114794 1165116..1165703 1 NC_002662.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1165703 engB 1114794 engB Lactococcus lactis subsp. lactis Il1403 ribosome biogenesis GTP-binding protein YsxC NP_267308.1 1165116 D 272623 CDS NP_267309.1 15673135 1114795 1165757..1166107 1 NC_002662.1 folic acid; dihydroneopterin aldolase 1166107 folB 1114795 folB Lactococcus lactis subsp. lactis Il1403 dihydroneopterin aldolase NP_267309.1 1165757 D 272623 CDS NP_267310.1 15673136 1114796 1166187..1167236 1 NC_002662.1 GTP-CH-I; folic acid; GTP cyclohydrolase I 1167236 folE 1114796 folE Lactococcus lactis subsp. lactis Il1403 GTP cyclohydrolase I NP_267310.1 1166187 D 272623 CDS NP_267311.1 15673137 1114797 1167233..1168306 1 NC_002662.1 folic acid; dihydropteroate synthase 1168306 folP 1114797 folP Lactococcus lactis subsp. lactis Il1403 dihydropteroate synthase NP_267311.1 1167233 D 272623 CDS NP_267312.1 15673138 1114798 1168309..1168806 1 NC_002662.1 hypothetical protein 1168806 ylgG 1114798 ylgG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267312.1 1168309 D 272623 CDS NP_267313.1 15673139 1114799 1168825..1170108 1 NC_002662.1 folic aci; folylpolyglutamate synthase 1170108 folC 1114799 folC Lactococcus lactis subsp. lactis Il1403 folylpolyglutamate synthase NP_267313.1 1168825 D 272623 CDS NP_267314.1 15673140 1114800 1170238..1170876 1 NC_002662.1 nucleotide and nucleoside interconversions; heterodimer of a deoxyadenosine and a deoxyguanosine kinase; deoxynucleoside kinase 1170876 dukB 1114800 dukB Lactococcus lactis subsp. lactis Il1403 deoxynucleoside kinase NP_267314.1 1170238 D 272623 CDS NP_267315.1 15673141 1114801 1171053..1172339 1 NC_002662.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1172339 hom 1114801 hom Lactococcus lactis subsp. lactis Il1403 homoserine dehydrogenase NP_267315.1 1171053 D 272623 CDS NP_267316.1 15673142 1114802 1172344..1173234 1 NC_002662.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1173234 thrB 1114802 thrB Lactococcus lactis subsp. lactis Il1403 homoserine kinase NP_267316.1 1172344 D 272623 CDS NP_267317.1 15673143 1114803 1173488..1174087 1 NC_002662.1 hypothetical protein 1174087 ylhB 1114803 ylhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267317.1 1173488 D 272623 CDS NP_267318.1 15673144 1114804 1174130..1175029 1 NC_002662.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1175029 murB 1114804 murB Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylenolpyruvoylglucosamine reductase NP_267318.1 1174130 D 272623 CDS NP_267319.1 15673145 1114805 1175681..1176967 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; spermidine/putrescine ABC transporter ATP-binding protein 1176967 potA 1114805 potA Lactococcus lactis subsp. lactis Il1403 spermidine/putrescine ABC transporter ATP-binding protein NP_267319.1 1175681 D 272623 CDS NP_267320.1 15673146 1114806 1176964..1177752 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; spermidine/putrescine ABC transporter permease 1177752 potB 1114806 potB Lactococcus lactis subsp. lactis Il1403 spermidine/putrescine ABC transporter permease NP_267320.1 1176964 D 272623 CDS NP_267321.1 15673147 1114807 1177754..1178554 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; spermidine/putrescine ABC transporter permease 1178554 potC 1114807 potC Lactococcus lactis subsp. lactis Il1403 spermidine/putrescine ABC transporter permease NP_267321.1 1177754 D 272623 CDS NP_267322.1 15673148 1114808 1178602..1179669 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; spermidine/putrescine ABC transporter substrate binding protein 1179669 potD 1114808 potD Lactococcus lactis subsp. lactis Il1403 spermidine/putrescine ABC transporter substrate binding protein NP_267322.1 1178602 D 272623 CDS NP_267323.1 15673149 1114809 1180044..1180904 1 NC_002662.1 general regulatory function; positive transcription regulator 1180904 yliA 1114809 yliA Lactococcus lactis subsp. lactis Il1403 positive transcription regulator NP_267323.1 1180044 D 272623 CDS NP_267324.1 15673150 1114810 1181003..1183261 1 NC_002662.1 probably Fe-S oxidoreductase, evidenced by COGnitor; hypothetical protein 1183261 yliB 1114810 yliB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267324.1 1181003 D 272623 CDS NP_267327.1 15673153 1114813 1184767..1185156 1 NC_002662.1 hypothetical protein 1185156 yliE 1114813 yliE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267327.1 1184767 D 272623 CDS NP_267328.1 15673154 1114814 1185119..1185682 1 NC_002662.1 hypothetical protein 1185682 yliF 1114814 yliF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267328.1 1185119 D 272623 CDS NP_267329.1 15673155 1114815 1186321..1186668 1 NC_002662.1 hypothetical protein 1186668 yliG 1114815 yliG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267329.1 1186321 D 272623 CDS NP_267330.1 15673156 1114816 1187132..1188595 1 NC_002662.1 membranes, lipoproteins, and porinsl affects resistance to gyrace inhibitor novobiocin; condensation of two molecules of phosphattidylglycerol; cardiolipin synthase 1188595 clsB 1114816 clsB Lactococcus lactis subsp. lactis Il1403 cardiolipin synthase NP_267330.1 1187132 D 272623 CDS NP_267331.1 15673157 1114818 complement(1191722..1192318) 1 NC_002662.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1192318 yljB 1114818 yljB Lactococcus lactis subsp. lactis Il1403 N-acetylmannosamine-6-phosphate 2-epimerase NP_267331.1 1191722 R 272623 CDS NP_267332.1 15673158 1114819 1192577..1193398 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 1193398 yljC 1114819 yljC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267332.1 1192577 D 272623 CDS NP_267333.1 15673159 1114820 1193685..1193930 1 NC_002662.1 hypothetical protein 1193930 yljD 1114820 yljD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267333.1 1193685 D 272623 CDS NP_267334.1 15673160 1114821 1194125..1195507 1 NC_002662.1 probably a SAM-dependent RNA methyltransferase, evidenced by COGnitor; hypothetical protein 1195507 yljE 1114821 yljE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267334.1 1194125 D 272623 CDS NP_267335.1 15673161 1114822 1195544..1197151 1 NC_002662.1 hypothetical protein 1197151 yljF 1114822 yljF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267335.1 1195544 D 272623 CDS NP_267336.1 15673162 1114823 1197153..1197773 1 NC_002662.1 probably a methylase, involved in menaquinone biosynthesis, evidenced by COGnitor; hypothetical protein 1197773 yljG 1114823 yljG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267336.1 1197153 D 272623 CDS NP_267337.1 15673163 1114824 1197839..1198045 1 NC_002662.1 hypothetical protein 1198045 yljH 1114824 yljH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267337.1 1197839 D 272623 CDS NP_267338.1 15673164 1114825 1198070..1199011 1 NC_002662.1 transport and binding protein; permease 1199011 yljI 1114825 yljI Lactococcus lactis subsp. lactis Il1403 permease NP_267338.1 1198070 D 272623 CDS NP_267339.1 15673165 1114826 1199039..1200295 1 NC_002662.1 hypothetical protein 1200295 yljJ 1114826 yljJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267339.1 1199039 D 272623 CDS NP_267340.1 15673166 1114827 1200450..1202114 1 NC_002662.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase 1202114 als 1114827 als Lactococcus lactis subsp. lactis Il1403 acetolactate synthase NP_267340.1 1200450 D 272623 CDS NP_267341.1 15673167 1114828 complement(1202315..1202488) 1 NC_002662.1 hypothetical protein 1202488 ymaB 1114828 ymaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267341.1 1202315 R 272623 CDS NP_267342.1 15673168 1114829 1203477..1204619 1 NC_002662.1 fermentation; malate oxidoreductase 1204619 mae 1114829 mae Lactococcus lactis subsp. lactis Il1403 malate oxidoreductase NP_267342.1 1203477 D 272623 CDS NP_267343.1 15673169 1114831 complement(1205754..1206683) 1 NC_002662.1 DeoR-family regulators; citrate lyase regulator 1206683 citR 1114831 citR Lactococcus lactis subsp. lactis Il1403 citrate lyase regulator NP_267343.1 1205754 R 272623 CDS NP_267344.1 15673170 1114832 1206765..1207805 1 NC_002662.1 TCA cycle; acetate-SH-citrate lyase ligase 1207805 citC 1114832 citC Lactococcus lactis subsp. lactis Il1403 acetate-SH-citrate lyase ligase NP_267344.1 1206765 D 272623 CDS NP_267345.1 15673171 1114833 1207795..1208085 1 NC_002662.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 1208085 citD 1114833 citD Lactococcus lactis subsp. lactis Il1403 citrate lyase subunit gamma NP_267345.1 1207795 D 272623 CDS NP_267346.1 15673172 1114834 1208087..1209001 1 NC_002662.1 TCA cycle; citrate lyase subunit beta 1209001 citE 1114834 citE Lactococcus lactis subsp. lactis Il1403 citrate lyase subunit beta NP_267346.1 1208087 D 272623 CDS NP_267347.1 15673173 1114835 1208991..1210529 1 NC_002662.1 TCA cycle; citrate lyase subunit alpha 1210529 citF 1114835 citF Lactococcus lactis subsp. lactis Il1403 citrate lyase subunit alpha NP_267347.1 1208991 D 272623 CDS YP_008998702.1 574739635 18245216 1210526..1211104 1 NC_002662.1 apo-citrate lyase 1211104 18245216 L0042a Lactococcus lactis subsp. lactis Il1403 apo-citrate lyase YP_008998702.1 1210526 D 272623 CDS YP_008998703.1 574739636 18245225 1211094..1211918 1 NC_002662.1 triphosphoribosyl-dephospho-CoA synthase 1211918 18245225 L0042b Lactococcus lactis subsp. lactis Il1403 triphosphoribosyl-dephospho-CoA synthase YP_008998703.1 1211094 D 272623 CDS NP_267348.1 15673174 1114838 1213089..1213409 1 NC_002662.1 hypothetical protein 1213409 ymbC 1114838 ymbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267348.1 1213089 D 272623 CDS NP_267349.1 15673175 1114839 1213381..1213527 1 NC_002662.1 hypothetical protein 1213527 ymbD 1114839 ymbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267349.1 1213381 D 272623 CDS NP_835314.1 30024026 1114840 1215335..1216084 1 NC_002662.1 similar to protease; hypothetical protein 1216084 ymbH 1114840 ymbH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835314.1 1215335 D 272623 CDS NP_267351.1 15673177 1114841 complement(1216209..1217048) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981E 1217048 tra981E 1114841 tra981E Lactococcus lactis subsp. lactis Il1403 transposase of IS981E NP_267351.1 1216209 R 272623 CDS NP_267352.1 15673178 1114842 complement(1217060..1217320) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 1217320 ymbI 1114842 ymbI Lactococcus lactis subsp. lactis Il1403 transposase NP_267352.1 1217060 R 272623 CDS NP_267353.1 15673179 1114843 1217351..1219600 1 NC_002662.1 hypothetical protein 1219600 ymbJ 1114843 ymbJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267353.1 1217351 D 272623 CDS NP_267354.1 15673180 1114844 1219654..1219971 1 NC_002662.1 hypothetical protein 1219971 ymbK 1114844 ymbK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267354.1 1219654 D 272623 CDS NP_267355.1 15673181 1114845 1219968..1220498 1 NC_002662.1 hypothetical protein 1220498 ymcA 1114845 ymcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267355.1 1219968 D 272623 CDS NP_267356.1 15673182 1114846 1220495..1221142 1 NC_002662.1 hypothetical protein 1221142 ymcB 1114846 ymcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267356.1 1220495 D 272623 CDS NP_267357.1 15673183 1114847 1221037..1221600 1 NC_002662.1 hypothetical protein 1221600 ymcC 1114847 ymcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267357.1 1221037 D 272623 CDS NP_267358.1 15673184 1114848 1221637..1221897 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 1221897 ymcD 1114848 ymcD Lactococcus lactis subsp. lactis Il1403 transposase NP_267358.1 1221637 D 272623 CDS NP_835315.1 30024027 1114849 1223001..1223219 1 NC_002662.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000; hypothetical protein 1223219 ymcE 1114849 ymcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835315.1 1223001 D 272623 CDS NP_267359.1 15673185 1114850 1223254..1224270 1 NC_002662.1 hypothetical protein 1224270 ymcF 1114850 ymcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267359.1 1223254 D 272623 CDS NP_267360.1 15673186 1114851 1224836..1226011 1 NC_002662.1 evidence experimental PMID:8195098; transposon related function; transposase of IS905 1226011 tra905 1114851 tra905 Lactococcus lactis subsp. lactis Il1403 transposase of IS905 NP_267360.1 1224836 D 272623 CDS NP_267361.1 15673187 1114852 1226204..1228201 1 NC_002662.1 degradation of RNA; ribonuclease II (RNB) family; ribonuclease 1228201 vacB2 1114852 vacB2 Lactococcus lactis subsp. lactis Il1403 ribonuclease NP_267361.1 1226204 D 272623 CDS NP_267362.1 15673188 1114853 1228672..1229754 1 NC_002662.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1229754 hisC 1114853 hisC Lactococcus lactis subsp. lactis Il1403 histidinol-phosphate aminotransferase NP_267362.1 1228672 D 272623 CDS NP_267363.1 15673189 1114854 1229867..1230727 1 NC_002662.1 ATP phosphoribosyltransferase regulatory subunit 1230727 hisZ 1114854 hisZ Lactococcus lactis subsp. lactis Il1403 ATP phosphoribosyltransferase regulatory subunit NP_267363.1 1229867 D 272623 CDS NP_267364.1 15673190 1114855 1230720..1231262 1 NC_002662.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase catalytic subunit 1231262 hisG 1114855 hisG Lactococcus lactis subsp. lactis Il1403 ATP phosphoribosyltransferase catalytic subunit NP_267364.1 1230720 D 272623 CDS NP_267365.1 15673191 1114856 1231329..1232624 1 NC_002662.1 evidence experimental PMID:1400209; histidine family; histidinol dehydrogenase 1232624 hisD 1114856 hisD Lactococcus lactis subsp. lactis Il1403 histidinol dehydrogenase NP_267365.1 1231329 D 272623 CDS NP_267366.1 15673192 1114858 1233461..1234063 1 NC_002662.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1234063 hisB 1114858 hisB Lactococcus lactis subsp. lactis Il1403 imidazoleglycerol-phosphate dehydratase NP_267366.1 1233461 D 272623 CDS NP_267367.1 15673193 1114859 1234060..1234848 1 NC_002662.1 drug and analog sensitivity; kanamycin kinase 1234848 ymdC 1114859 ymdC Lactococcus lactis subsp. lactis Il1403 kanamycin kinase NP_267367.1 1234060 D 272623 CDS NP_267368.1 15673194 1114860 1234887..1235495 1 NC_002662.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1235495 hisH 1114860 hisH Lactococcus lactis subsp. lactis Il1403 imidazole glycerol phosphate synthase subunit HisH NP_267368.1 1234887 D 272623 CDS NP_267369.1 15673195 1114861 1235496..1236215 1 NC_002662.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1236215 hisA 1114861 hisA Lactococcus lactis subsp. lactis Il1403 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_267369.1 1235496 D 272623 CDS NP_267370.1 15673196 1114862 1236205..1236984 1 NC_002662.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1236984 hisF 1114862 hisF Lactococcus lactis subsp. lactis Il1403 imidazole glycerol phosphate synthase subunit HisF NP_267370.1 1236205 D 272623 CDS NP_267371.1 15673197 1114863 1236981..1237619 1 NC_002662.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 1237619 hisI 1114863 hisI Lactococcus lactis subsp. lactis Il1403 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase NP_267371.1 1236981 D 272623 CDS NP_267372.1 15673198 1114864 1237620..1238429 1 NC_002662.1 histidine family; histidinol phosphatase 1238429 hisK 1114864 hisK Lactococcus lactis subsp. lactis Il1403 histidinol phosphatase NP_267372.1 1237620 D 272623 CDS NP_267373.1 15673199 1114865 complement(1238443..1239402) 1 NC_002662.1 hypothetical protein 1239402 ymdE 1114865 ymdE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267373.1 1238443 R 272623 CDS NP_267374.1 15673200 1114867 1241356..1242318 1 NC_002662.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1242318 leuB 1114867 leuB Lactococcus lactis subsp. lactis Il1403 3-isopropylmalate dehydrogenase NP_267374.1 1241356 D 272623 CDS NP_267375.1 15673201 1114868 complement(1242353..1242775) 1 NC_002662.1 hypothetical protein 1242775 ymeA 1114868 ymeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267375.1 1242353 R 272623 CDS NP_267376.1 15673202 1114869 1242879..1244261 1 NC_002662.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1244261 leuC 1114869 leuC Lactococcus lactis subsp. lactis Il1403 isopropylmalate isomerase large subunit NP_267376.1 1242879 D 272623 CDS NP_267377.1 15673203 1114870 1244281..1244856 1 NC_002662.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1244856 leuD 1114870 leuD Lactococcus lactis subsp. lactis Il1403 isopropylmalate isomerase small subunit NP_267377.1 1244281 D 272623 CDS NP_267378.2 30024028 1114871 1244870..1245649 1 NC_002662.1 transport and binding protein; branched chain amino acid biosynthesis operon; ABC transporter ATP-binding protein 1245649 ymeB 1114871 ymeB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267378.2 1244870 D 272623 CDS NP_267379.1 15673205 1114872 1245771..1247483 1 NC_002662.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1247483 ilvD 1114872 ilvD Lactococcus lactis subsp. lactis Il1403 dihydroxy-acid dehydratase NP_267379.1 1245771 D 272623 CDS NP_267380.1 15673206 1114873 1247599..1249221 1 NC_002662.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 1249221 ilvB 1114873 ilvB Lactococcus lactis subsp. lactis Il1403 acetolactate synthase catalytic subunit NP_267380.1 1247599 D 272623 CDS NP_267381.1 15673207 1114874 1249214..1249690 1 NC_002662.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 1249690 ilvH 1114874 ilvH Lactococcus lactis subsp. lactis Il1403 acetolactate synthase 3 regulatory subunit NP_267381.1 1249214 D 272623 CDS NP_267382.1 15673208 1114875 1249736..1250758 1 NC_002662.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 1250758 ilvC 1114875 ilvC Lactococcus lactis subsp. lactis Il1403 ketol-acid reductoisomerase NP_267382.1 1249736 D 272623 CDS NP_267383.1 15673209 1114876 1250814..1252064 1 NC_002662.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1252064 ilvA 1114876 ilvA Lactococcus lactis subsp. lactis Il1403 threonine dehydratase NP_267383.1 1250814 D 272623 CDS NP_267384.1 15673210 1114877 1252180..1252890 1 NC_002662.1 evidence experimental PMID:8779600; fermentation; converts acetolactate into acetoin;may be a mechanism for controlling the internal pH of cells in stationary phase; alpha-acetolactate decarboxylase 1252890 aldB 1114877 aldB Lactococcus lactis subsp. lactis Il1403 alpha-acetolactate decarboxylase NP_267384.1 1252180 D 272623 CDS NP_267385.1 15673211 1114878 1252931..1253311 1 NC_002662.1 regulatory protein; general regulatory function; AldR 1253311 aldR 1114878 aldR Lactococcus lactis subsp. lactis Il1403 AldR NP_267385.1 1252931 D 272623 CDS NP_267386.1 15673212 1114880 1254565..1256697 1 NC_002662.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1256697 topA 1114880 topA Lactococcus lactis subsp. lactis Il1403 DNA topoisomerase I NP_267386.1 1254565 D 272623 CDS NP_267387.1 15673213 1114881 1256769..1258112 1 NC_002662.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 1258112 gidC 1114881 gidC Lactococcus lactis subsp. lactis Il1403 tRNA (uracil-5-)-methyltransferase Gid NP_267387.1 1256769 D 272623 CDS NP_267388.1 15673214 1114882 complement(1258157..1259227) 1 NC_002662.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1259227 xerS 1114882 xerS Lactococcus lactis subsp. lactis Il1403 site-specific tyrosine recombinase XerS NP_267388.1 1258157 R 272623 CDS NP_267391.1 15673217 1114884 1261619..1263337 1 NC_002662.1 hypothetical protein 1263337 ymgC 1114884 ymgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267391.1 1261619 D 272623 CDS NP_267392.1 15673218 1114885 1263405..1264316 1 NC_002662.1 LysR-family regulator; LysR family transcriptional regulator 1264316 rlrA 1114885 rlrA Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_267392.1 1263405 D 272623 CDS NP_267393.1 15673219 1114886 complement(1264586..1265515) 1 NC_002662.1 evidence experimental PMID:7744873; aspartate family; component of sucrose-nisin transposon Tn5306; N5-carboxyethyl-ornithine synthase 1265515 ceo 1114886 ceo Lactococcus lactis subsp. lactis Il1403 N5-carboxyethyl-ornithine synthase NP_267393.1 1264586 R 272623 CDS NP_267394.1 15673220 1114887 complement(1265554..1265733) 1 NC_002662.1 similar to C-part of 37 kD protein from sucrose-nisin transposon Tn5306; hypothetical protein 1265733 ymgF 1114887 ymgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267394.1 1265554 R 272623 CDS NP_267395.1 15673221 1114888 complement(1265891..1266442) 1 NC_002662.1 similar to a 20 kD protein from sucrose-nisin transposon Tn5306; hypothetical protein 1266442 ymgG 1114888 ymgG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267395.1 1265891 R 272623 CDS NP_267396.1 15673222 1114889 complement(1266463..1266651) 1 NC_002662.1 similar to a 6-kDa protein from sucrose-nisin transposon Tn5306; hypothetical protein 1266651 ymgH 1114889 ymgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267396.1 1266463 R 272623 CDS NP_267397.1 15673223 1114890 complement(1266661..1267221) 1 NC_002662.1 hypothetical protein 1267221 ymgI 1114890 ymgI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267397.1 1266661 R 272623 CDS NP_267398.1 15673224 1114891 complement(1267256..1267498) 1 NC_002662.1 similar to YdaS of Bacillus subtilis; hypothetical protein 1267498 ymgJ 1114891 ymgJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267398.1 1267256 R 272623 CDS NP_267399.1 15673225 1114892 1267992..1268834 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1268834 ymgK 1114892 ymgK Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267399.1 1267992 D 272623 CDS NP_267400.1 15673226 1114893 complement(1269307..1270044) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; glycerol utilization pathway; glycerol uptake facilitator 1270044 glpF2 1114893 glpF2 Lactococcus lactis subsp. lactis Il1403 glycerol uptake facilitator NP_267400.1 1269307 R 272623 CDS NP_267401.1 15673227 1114894 complement(1270095..1271924) 1 NC_002662.1 anaerobic energy metabolism; glycerol utilization pathway; glycerol-3-phosphate dehydrogenase 1271924 glpD 1114894 glpD Lactococcus lactis subsp. lactis Il1403 glycerol-3-phosphate dehydrogenase NP_267401.1 1270095 R 272623 CDS NP_267402.1 15673228 1114895 complement(1271961..1273457) 1 NC_002662.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1273457 glpK 1114895 glpK Lactococcus lactis subsp. lactis Il1403 glycerol kinase NP_267402.1 1271961 R 272623 CDS NP_267403.1 15673229 1114896 complement(1273826..1275292) 1 NC_002662.1 hypothetical protein 1275292 ymhA 1114896 ymhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267403.1 1273826 R 272623 CDS NP_267404.1 15673230 1114897 complement(1275416..1276255) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981G 1276255 tra981G 1114897 tra981G Lactococcus lactis subsp. lactis Il1403 transposase of IS981G NP_267404.1 1275416 R 272623 CDS NP_267405.1 15673231 1114898 complement(1276267..1276527) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 1276527 ymhB 1114898 ymhB Lactococcus lactis subsp. lactis Il1403 transposase NP_267405.1 1276267 R 272623 CDS NP_267406.1 15673232 1114899 complement(1276583..1277206) 1 NC_002662.1 hypothetical protein 1277206 ymhC 1114899 ymhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267406.1 1276583 R 272623 CDS NP_267407.1 15673233 1114900 1277443..1278918 1 NC_002662.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1278918 amyL 1114900 amyL Lactococcus lactis subsp. lactis Il1403 alpha-amylase NP_267407.1 1277443 D 272623 CDS NP_267408.1 15673234 1114901 complement(1278985..1280136) 1 NC_002662.1 anaerobic energy metabolism; L-lactate utilization gene; L-lactate oxidase 1280136 lctO 1114901 lctO Lactococcus lactis subsp. lactis Il1403 L-lactate oxidase NP_267408.1 1278985 R 272623 CDS NP_267409.1 15673235 1114902 complement(1280370..1281392) 1 NC_002662.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1281392 aroH 1114902 aroH Lactococcus lactis subsp. lactis Il1403 phospho-2-dehydro-3-deoxyheptonate aldolase NP_267409.1 1280370 R 272623 CDS NP_267410.1 15673236 1114903 complement(1281756..1282607) 1 NC_002662.1 aspartate family; 5,10-methylenetetrahydrofolate reductase 1282607 metF 1114903 metF Lactococcus lactis subsp. lactis Il1403 5,10-methylenetetrahydrofolate reductase NP_267410.1 1281756 R 272623 CDS NP_267411.2 30024031 1114904 complement(1282597..1284870) 1 NC_002662.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1284870 metE 1114904 metE Lactococcus lactis subsp. lactis Il1403 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_267411.2 1282597 R 272623 CDS NP_267412.1 15673238 1114905 complement(1285022..1285675) 1 NC_002662.1 general regulatory function; metalloregulator 1285675 ymiA 1114905 ymiA Lactococcus lactis subsp. lactis Il1403 metalloregulator NP_267412.1 1285022 R 272623 CDS NP_267413.1 15673239 1114906 complement(1285769..1288501) 1 NC_002662.1 transort and binding protein, cations; cation-transporting P-ATPase 1288501 mgtA 1114906 mgtA Lactococcus lactis subsp. lactis Il1403 cation-transporting P-ATPase NP_267413.1 1285769 R 272623 CDS NP_267414.1 15673240 1114907 complement(1288984..1290270) 1 NC_002662.1 D-alanine transfer protein 1290270 dltD 1114907 dltD Lactococcus lactis subsp. lactis Il1403 D-alanine transfer protein NP_267414.1 1288984 R 272623 CDS NP_267415.1 15673241 1114908 complement(1290260..1290499) 1 NC_002662.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 1290499 dltC 1114908 dltC Lactococcus lactis subsp. lactis Il1403 D-alanine--poly(phosphoribitol) ligase subunit 2 NP_267415.1 1290260 R 272623 CDS NP_267416.1 15673242 1114909 complement(1290542..1291765) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; may be involved in transport of activated D-alanine through the membrane; peptidoglycan biosynthesis protein 1291765 dltB 1114909 dltB Lactococcus lactis subsp. lactis Il1403 peptidoglycan biosynthesis protein NP_267416.1 1290542 R 272623 CDS NP_267417.1 15673243 1114910 complement(1291765..1293264) 1 NC_002662.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 1293264 dltA 1114910 dltA Lactococcus lactis subsp. lactis Il1403 D-alanine--poly(phosphoribitol) ligase subunit 1 NP_267417.1 1291765 R 272623 CDS NP_267418.1 15673244 1114911 complement(1293610..1294257) 1 NC_002662.1 thiamin-phosphate pyrophosphorylase 1294257 thiE 1114911 thiE Lactococcus lactis subsp. lactis Il1403 thiamin-phosphate pyrophosphorylase NP_267418.1 1293610 R 272623 CDS NP_267419.1 15673245 1114912 complement(1294247..1295050) 1 NC_002662.1 thiamine; also functions in a salvage pathway; phosphomethylpyrimidine kinase 1295050 thiD1 1114912 thiD1 Lactococcus lactis subsp. lactis Il1403 phosphomethylpyrimidine kinase NP_267419.1 1294247 R 272623 CDS NP_267420.1 15673246 1114913 complement(1295064..1295816) 1 NC_002662.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 1295816 thiM 1114913 thiM Lactococcus lactis subsp. lactis Il1403 hydroxyethylthiazole kinase NP_267420.1 1295064 R 272623 CDS NP_267421.1 15673247 1114914 complement(1296101..1298575) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; glycosyltransferase, probably involved in cell wall biogenesis, evidenced by COGnitor; glycosyl transferase family protein 1298575 ymjE 1114914 ymjE Lactococcus lactis subsp. lactis Il1403 glycosyl transferase family protein NP_267421.1 1296101 R 272623 CDS NP_267422.1 15673248 1114915 complement(1298565..1299653) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; UDP-N-acetylglucosamine 2-epimerase 1299653 ymjF 1114915 ymjF Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylglucosamine 2-epimerase NP_267422.1 1298565 R 272623 CDS NP_267424.1 15673250 1114917 complement(1300979..1301344) 1 NC_002662.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1301344 rplL 1114917 rplL Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L7/L12 NP_267424.1 1300979 R 272623 CDS NP_267425.1 15673251 1114918 complement(1301414..1301929) 1 NC_002662.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1301929 rplJ 1114918 rplJ Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L10 NP_267425.1 1301414 R 272623 CDS NP_267426.1 15673252 1114919 complement(1302151..1302339) 1 NC_002662.1 hypothetical protein 1302339 ynaA 1114919 ynaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267426.1 1302151 R 272623 CDS NP_267427.1 15673253 1114920 complement(1302355..1303113) 1 NC_002662.1 general regulatory function; transcriptional regulator 1303113 ynaB 1114920 ynaB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267427.1 1302355 R 272623 CDS NP_267428.1 15673254 1114921 complement(1303234..1305060) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 1305060 ynaC 1114921 ynaC Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_267428.1 1303234 R 272623 CDS NP_267429.1 15673255 1114922 complement(1305044..1306861) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 1306861 ynaD 1114922 ynaD Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_267429.1 1305044 R 272623 CDS NP_267430.2 30024032 1114923 complement(1307010..1307630) 1 NC_002662.1 hypothetical protein 1307630 ynaE 1114923 ynaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267430.2 1307010 R 272623 CDS NP_267431.2 30024033 1114924 complement(1307979..1308698) 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; synthesis of pseudouridine from uracil-2650 in 23S ribosomal RNA; family 1 of pseudouridine synthases; pseudouridine synthase 1308698 rluB 1114924 rluB Lactococcus lactis subsp. lactis Il1403 pseudouridine synthase NP_267431.2 1307979 R 272623 CDS NP_267432.2 30024034 1114925 complement(1308685..1309251) 1 NC_002662.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1309251 scpB 1114925 scpB Lactococcus lactis subsp. lactis Il1403 segregation and condensation protein B NP_267432.2 1308685 R 272623 CDS NP_267433.1 15673259 1114926 complement(1309244..1309972) 1 NC_002662.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1309972 scpA 1114926 scpA Lactococcus lactis subsp. lactis Il1403 segregation and condensation protein A NP_267433.1 1309244 R 272623 CDS NP_267434.2 30024035 1114927 complement(1310002..1310718) 1 NC_002662.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1310718 xerD 1114927 xerD Lactococcus lactis subsp. lactis Il1403 site-specific tyrosine recombinase XerD NP_267434.2 1310002 R 272623 CDS NP_267435.1 15673261 1114928 complement(1310696..1311157) 1 NC_002662.1 hypothetical protein 1311157 ynbB 1114928 ynbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267435.1 1310696 R 272623 CDS NP_267436.1 15673262 1114929 complement(1311188..1311691) 1 NC_002662.1 hypothetical protein 1311691 ynbC 1114929 ynbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267436.1 1311188 R 272623 CDS NP_267439.1 15673265 1114932 complement(1313315..1313554) 1 NC_002662.1 hypothetical protein 1313554 ynbE 1114932 ynbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267439.1 1313315 R 272623 CDS NP_267440.1 15673266 1114933 complement(1313706..1314965) 1 NC_002662.1 aspartate family; diaminopimelate decarboxylase 1314965 lysA 1114933 lysA Lactococcus lactis subsp. lactis Il1403 diaminopimelate decarboxylase NP_267440.1 1313706 R 272623 CDS NP_267441.1 15673267 1114934 complement(1315082..1316521) 1 NC_002662.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 1316521 gltD 1114934 gltD Lactococcus lactis subsp. lactis Il1403 glutamate synthase subunit beta NP_267441.1 1315082 R 272623 CDS NP_267442.1 15673268 1114935 complement(1316521..1320981) 1 NC_002662.1 glutamate family; nitrogen metabolism; brings together nitrogen and carbon metabolism; glutamate synthase large subunit 1320981 gltB 1114935 gltB Lactococcus lactis subsp. lactis Il1403 glutamate synthase large subunit NP_267442.1 1316521 R 272623 CDS NP_267443.1 15673269 1114936 1321150..1321761 1 NC_002662.1 sugars; acetyltransferase 1321761 yncA 1114936 yncA Lactococcus lactis subsp. lactis Il1403 acetyltransferase NP_267443.1 1321150 D 272623 CDS NP_267444.1 15673270 1114937 complement(1321794..1322816) 1 NC_002662.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1322816 bcaT 1114937 bcaT Lactococcus lactis subsp. lactis Il1403 branched-chain amino acid aminotransferase NP_267444.1 1321794 R 272623 CDS NP_267445.1 15673271 1114938 1322977..1323723 1 NC_002662.1 integral membrane protein; hypothetical protein 1323723 yncB 1114938 yncB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267445.1 1322977 D 272623 CDS NP_267446.1 15673272 1114939 complement(1323836..1325236) 1 NC_002662.1 evidence experimental PMID:9484886; energy metabolism, amino acids and amines; glutamate decarboxylase 1325236 gadB 1114939 gadB Lactococcus lactis subsp. lactis Il1403 glutamate decarboxylase NP_267446.1 1323836 R 272623 CDS NP_267447.1 15673273 1114940 complement(1325256..1326767) 1 NC_002662.1 evidence experimental PMID:9484886; transport and binding protein; amino acids, peptides and amines; glutamate-gamma-aminobutyrate 1326767 gadC 1114940 gadC Lactococcus lactis subsp. lactis Il1403 glutamate-gamma-aminobutyrate NP_267447.1 1325256 R 272623 CDS NP_267448.1 15673274 1114941 complement(1326911..1327741) 1 NC_002662.1 evidence experimental PMID:9484886; activates chloride dependent transcription of gadCB ,homologous to the activator Rgg from Streptococcus gordonii.; positive regulator 1327741 gadR 1114941 gadR Lactococcus lactis subsp. lactis Il1403 positive regulator NP_267448.1 1326911 R 272623 CDS NP_267449.1 15673275 1114942 complement(1328294..1329070) 1 NC_002662.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1329070 rnhB 1114942 rnhB Lactococcus lactis subsp. lactis Il1403 ribonuclease HII NP_267449.1 1328294 R 272623 CDS NP_267450.1 15673276 1114943 complement(1329206..1330054) 1 NC_002662.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1330054 rbgA 1114943 rbgA Lactococcus lactis subsp. lactis Il1403 ribosomal biogenesis GTPase NP_267450.1 1329206 R 272623 CDS NP_267451.1 15673277 1114944 complement(1330278..1330823) 1 NC_002662.1 hypothetical protein 1330823 yndA 1114944 yndA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267451.1 1330278 R 272623 CDS NP_267452.1 15673278 1114945 complement(1330915..1331664) 1 NC_002662.1 hypothetical protein 1331664 yndB 1114945 yndB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267452.1 1330915 R 272623 CDS NP_267453.1 15673279 1114946 1331842..1332603 1 NC_002662.1 DeoR-family regulator; transcriptional regulator 1332603 rdrB 1114946 rdrB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267453.1 1331842 D 272623 CDS NP_267456.1 15673282 1114949 complement(1334047..1334574) 1 NC_002662.1 hypothetical protein 1334574 yndE 1114949 yndE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267456.1 1334047 R 272623 CDS NP_267457.1 15673283 1114950 complement(1334649..1336610) 1 NC_002662.1 similar to internalin of Listeria monocytogenes; membrane protein; hypothetical protein 1336610 yndF 1114950 yndF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267457.1 1334649 R 272623 CDS NP_267458.1 15673284 1114951 complement(1336910..1337914) 1 NC_002662.1 transort and binding protein, cations; metal ABC transporter substrate binding protein 1337914 yndG 1114951 yndG Lactococcus lactis subsp. lactis Il1403 metal ABC transporter substrate binding protein NP_267458.1 1336910 R 272623 CDS NP_267459.1 15673285 1114952 1337988..1338935 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983D 1338935 tra983D 1114952 tra983D Lactococcus lactis subsp. lactis Il1403 transposase of IS983D NP_267459.1 1337988 D 272623 CDS NP_267460.1 15673286 1114953 complement(1338895..1340268) 1 NC_002662.1 energy metabolism, amino acids and amines; indole-3-pyruvate decarboxylase 1340268 ipd 1114953 ipd Lactococcus lactis subsp. lactis Il1403 indole-3-pyruvate decarboxylase NP_267460.1 1338895 R 272623 CDS NP_267461.1 15673287 1114954 1340403..1340873 1 NC_002662.1 MarR-family regulator; transcriptional regulator 1340873 rmaF 1114954 rmaF Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267461.1 1340403 D 272623 CDS NP_267462.1 15673288 1114955 1340924..1341745 1 NC_002662.1 LysR-family regulator; LysR family transcriptional regulator 1341745 rlrC 1114955 rlrC Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_267462.1 1340924 D 272623 CDS NP_267463.1 15673289 1114956 complement(1341786..1342559) 1 NC_002662.1 hypothetical protein 1342559 yneB 1114956 yneB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267463.1 1341786 R 272623 CDS NP_267464.1 15673290 1114957 complement(1342666..1342863) 1 NC_002662.1 hypothetical protein 1342863 yneC 1114957 yneC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267464.1 1342666 R 272623 CDS NP_267465.1 15673291 1114958 1343087..1343899 1 NC_002662.1 aerobic energy metabolism; short chain dehydrogenase 1343899 yneD 1114958 yneD Lactococcus lactis subsp. lactis Il1403 short chain dehydrogenase NP_267465.1 1343087 D 272623 CDS NP_267466.1 15673292 1114959 1343916..1344890 1 NC_002662.1 AraC-family regulator; similar to OruR of Pseudomonas aeruginosa.; transcriptional regulator 1344890 yneE 1114959 yneE Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267466.1 1343916 D 272623 CDS NP_267467.1 15673293 1114960 1345039..1345575 1 NC_002662.1 hypothetical protein 1345575 yneF 1114960 yneF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267467.1 1345039 D 272623 CDS NP_267468.1 15673294 1114961 complement(1345631..1345954) 1 NC_002662.1 hypothetical protein 1345954 yneG 1114961 yneG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267468.1 1345631 R 272623 CDS NP_267469.2 30024036 1114962 complement(1346013..1346384) 1 NC_002662.1 hypothetical protein 1346384 yneH 1114962 yneH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267469.2 1346013 R 272623 CDS NP_267470.1 15673296 1114963 complement(1346573..1348459) 1 NC_002662.1 folic acid; folate biosynthesis pathway; para-aminobenzoate synthase component I 1348459 pabB 1114963 pabB Lactococcus lactis subsp. lactis Il1403 para-aminobenzoate synthase component I NP_267470.1 1346573 R 272623 CDS NP_267471.1 15673297 1114964 complement(1348464..1349045) 1 NC_002662.1 folic acid; folate biosynthesis pathway; para-aminobenzoate synthase component II 1349045 pabA 1114964 pabA Lactococcus lactis subsp. lactis Il1403 para-aminobenzoate synthase component II NP_267471.1 1348464 R 272623 CDS NP_267472.1 15673298 1114965 complement(1349213..1350154) 1 NC_002662.1 transport and binding protein, cations; belongs to streptococcal LraI protein family, involved on adherence to extracellular matrix, important factor in the pathogenesis and infection; manganese ABC transporter substrate binding protein 1350154 mtsA 1114965 mtsA Lactococcus lactis subsp. lactis Il1403 manganese ABC transporter substrate binding protein NP_267472.1 1349213 R 272623 CDS NP_267473.1 15673299 1114966 complement(1350147..1350992) 1 NC_002662.1 transort and binding protein, cations; manganese ABC transporter permease 1350992 mtsC 1114966 mtsC Lactococcus lactis subsp. lactis Il1403 manganese ABC transporter permease NP_267473.1 1350147 R 272623 CDS NP_267474.1 15673300 1114967 complement(1351000..1351713) 1 NC_002662.1 transort and binding protein, cations; manganese ABC transporter ATP binding protein 1351713 mtsB 1114967 mtsB Lactococcus lactis subsp. lactis Il1403 manganese ABC transporter ATP binding protein NP_267474.1 1351000 R 272623 CDS NP_267475.1 15673301 1114968 1351988..1352401 1 NC_002662.1 hypothetical protein 1352401 ynfC 1114968 ynfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267475.1 1351988 D 272623 CDS NP_267476.1 15673302 1114969 complement(1352482..1352715) 1 NC_002662.1 hypothetical protein 1352715 ynfD 1114969 ynfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267476.1 1352482 R 272623 CDS NP_267477.1 15673303 1114970 complement(1352843..1355983) 1 NC_002662.1 degradation of DNA; affects genetic recombination and the variability of DNA palindromes; may have nuclease activity related to RecBCD; ATP-dependent dsDNA exonuclease 1355983 sbcC 1114970 sbcC Lactococcus lactis subsp. lactis Il1403 ATP-dependent dsDNA exonuclease NP_267477.1 1352843 R 272623 CDS NP_267478.1 15673304 1114971 complement(1355986..1357158) 1 NC_002662.1 degradation of DNA; probably involved in genetic recombination; exonuclease 1357158 sbcD 1114971 sbcD Lactococcus lactis subsp. lactis Il1403 exonuclease NP_267478.1 1355986 R 272623 CDS NP_267479.1 15673305 1114972 complement(1357310..1358248) 1 NC_002662.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 1358248 panE 1114972 panE Lactococcus lactis subsp. lactis Il1403 2-dehydropantoate 2-reductase NP_267479.1 1357310 R 272623 CDS NP_267480.1 15673306 1114973 complement(1358448..1358867) 1 NC_002662.1 hypothetical protein 1358867 ynfG 1114973 ynfG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267480.1 1358448 R 272623 CDS NP_267481.1 15673307 1114974 complement(1359619..1361796) 1 NC_002662.1 hypothetical protein 1361796 ynfH 1114974 ynfH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267481.1 1359619 R 272623 CDS NP_267482.1 15673308 1114975 complement(1362143..1362586) 1 NC_002662.1 hypothetical protein 1362586 yngA 1114975 yngA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267482.1 1362143 R 272623 CDS NP_267483.1 15673309 1114976 1362894..1364516 1 NC_002662.1 transport and binding protein; similar to fibronectin-binding proteins of Streptococci; fibronectin-binding protein 1364516 yngB 1114976 yngB Lactococcus lactis subsp. lactis Il1403 fibronectin-binding protein NP_267483.1 1362894 D 272623 CDS NP_267484.1 15673310 1114978 1365549..1367069 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar ABC transporter ATP binding protein 1367069 yngE 1114978 yngE Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter ATP binding protein NP_267484.1 1365549 D 272623 CDS NP_267485.1 15673311 1114979 1367062..1368156 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar ABC transporter permease 1368156 yngF 1114979 yngF Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter permease NP_267485.1 1367062 D 272623 CDS NP_267486.1 15673312 1114980 1368153..1369106 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar ABC transporter permease 1369106 yngG 1114980 yngG Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter permease NP_267486.1 1368153 D 272623 CDS NP_267487.1 15673313 1114981 complement(1369224..1370201) 1 NC_002662.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1370201 ldh 1114981 ldh Lactococcus lactis subsp. lactis Il1403 L-lactate dehydrogenase NP_267487.1 1369224 R 272623 CDS NP_267488.1 15673314 1114982 complement(1370319..1371827) 1 NC_002662.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1371827 pyk 1114982 pyk Lactococcus lactis subsp. lactis Il1403 pyruvate kinase NP_267488.1 1370319 R 272623 CDS NP_267489.1 15673315 1114983 complement(1371915..1372937) 1 NC_002662.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1372937 pfkA 1114983 pfkA Lactococcus lactis subsp. lactis Il1403 6-phosphofructokinase NP_267489.1 1371915 R 272623 CDS NP_267490.1 15673316 1114984 complement(1373039..1373314) 1 NC_002662.1 hypothetical protein 1373314 ynhA 1114984 ynhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267490.1 1373039 R 272623 CDS NP_267491.1 15673317 1114985 complement(1373323..1374471) 1 NC_002662.1 amino sugars; N-acetylglucosamine-6-phosphate deacetylase 1374471 nagA 1114985 nagA Lactococcus lactis subsp. lactis Il1403 N-acetylglucosamine-6-phosphate deacetylase NP_267491.1 1373323 R 272623 CDS NP_267492.1 15673318 1114986 complement(1374644..1375822) 1 NC_002662.1 similar to YaaN of Bacillus subtilis; hypothetical protein 1375822 ynhC 1114986 ynhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267492.1 1374644 R 272623 CDS NP_267493.1 15673319 1114987 complement(1375967..1376593) 1 NC_002662.1 similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein; hypothetical protein 1376593 ynhD 1114987 ynhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267493.1 1375967 R 272623 CDS NP_267494.1 15673320 1114988 1376785..1377810 1 NC_002662.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1377810 gpsA 1114988 gpsA Lactococcus lactis subsp. lactis Il1403 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_267494.1 1376785 D 272623 CDS NP_267495.1 15673321 1114989 1377854..1378795 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; hyaluronate synthesis pathway; UTP-glucose-1-phosphate uridylyltransferase 1378795 hasC 1114989 hasC Lactococcus lactis subsp. lactis Il1403 UTP-glucose-1-phosphate uridylyltransferase NP_267495.1 1377854 D 272623 CDS NP_267496.1 15673322 1114990 1378866..1379273 1 NC_002662.1 contains signal peptide; hypothetical protein 1379273 ynhH 1114990 ynhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267496.1 1378866 D 272623 CDS NP_267497.1 15673323 1114991 1379270..1379800 1 NC_002662.1 hypothetical protein 1379800 ynhI 1114991 ynhI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267497.1 1379270 D 272623 CDS NP_267498.1 15673324 1114992 1379791..1380750 1 NC_002662.1 heptaprenyl diphosphate synthase component II 1380750 ispB 1114992 ispB Lactococcus lactis subsp. lactis Il1403 heptaprenyl diphosphate synthase component II NP_267498.1 1379791 D 272623 CDS NP_267499.1 15673325 1114993 1380747..1381463 1 NC_002662.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1381463 gidB 1114993 gidB Lactococcus lactis subsp. lactis Il1403 16S rRNA methyltransferase GidB NP_267499.1 1380747 D 272623 CDS NP_267500.1 15673326 1114994 complement(1381693..1381944) 1 NC_002662.1 similar to cytochrome oxidase subunit III; hypothetical protein 1381944 yniC 1114994 yniC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267500.1 1381693 R 272623 CDS NP_267501.1 15673327 1114995 complement(1381946..1382659) 1 NC_002662.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1382659 pyrF 1114995 pyrF Lactococcus lactis subsp. lactis Il1403 orotidine 5'-phosphate decarboxylase NP_267501.1 1381946 R 272623 CDS NP_267502.1 15673328 1114996 complement(1382809..1383744) 1 NC_002662.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 1383744 pydB 1114996 pydB Lactococcus lactis subsp. lactis Il1403 dihydroorotate dehydrogenase 1B NP_267502.1 1382809 R 272623 CDS NP_267503.1 15673329 1114997 complement(1383817..1384605) 1 NC_002662.1 pyrimidine ribonucleotide biosynthesis; dihydroorotate dehydrogenase electron transfer subunit 1384605 pyrZ 1114997 pyrZ Lactococcus lactis subsp. lactis Il1403 dihydroorotate dehydrogenase electron transfer subunit NP_267503.1 1383817 R 272623 CDS NP_267504.1 15673330 1114998 complement(1385072..1386436) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to LmrB of Bacillus subtilis; drug-export protein 1386436 yniG 1114998 yniG Lactococcus lactis subsp. lactis Il1403 drug-export protein NP_267504.1 1385072 R 272623 CDS NP_267505.2 30024037 1114999 1386813..1388024 1 NC_002662.1 hypothetical protein 1388024 yniH 1114999 yniH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267505.2 1386813 D 272623 CDS NP_267506.1 15673332 1115000 1388184..1389323 1 NC_002662.1 hypothetical protein 1389323 yniI 1115000 yniI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267506.1 1388184 D 272623 CDS NP_267507.1 15673333 1115001 1389320..1390105 1 NC_002662.1 hypothetical protein 1390105 yniJ 1115001 yniJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267507.1 1389320 D 272623 CDS NP_267508.1 15673334 1115002 complement(1390135..1390692) 1 NC_002662.1 pseudouridine synthase 1390692 rluC 1115002 rluC Lactococcus lactis subsp. lactis Il1403 pseudouridine synthase NP_267508.1 1390135 R 272623 CDS NP_267509.1 15673335 1115003 complement(1391010..1391336) 1 NC_002662.1 hypothetical protein 1391336 ynjB 1115003 ynjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267509.1 1391010 R 272623 CDS NP_267510.1 15673336 1115004 complement(1391305..1392174) 1 NC_002662.1 hypothetical protein 1392174 ynjC 1115004 ynjC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267510.1 1391305 R 272623 CDS NP_267511.1 15673337 1115005 complement(1392252..1393064) 1 NC_002662.1 hypothetical protein 1393064 ynjD 1115005 ynjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267511.1 1392252 R 272623 CDS NP_267512.1 15673338 1115006 complement(1393039..1393383) 1 NC_002662.1 hypothetical protein 1393383 ynjE 1115006 ynjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267512.1 1393039 R 272623 CDS NP_267513.1 15673339 1115007 complement(1393430..1394434) 1 NC_002662.1 hypothetical protein 1394434 ynjF 1115007 ynjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267513.1 1393430 R 272623 CDS NP_267514.1 15673340 1115008 complement(1394446..1395546) 1 NC_002662.1 hypothetical protein 1395546 ynjG 1115008 ynjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267514.1 1394446 R 272623 CDS NP_267515.1 15673341 1115009 1395697..1396644 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983E 1396644 tra983E 1115009 tra983E Lactococcus lactis subsp. lactis Il1403 transposase of IS983E NP_267515.1 1395697 D 272623 CDS NP_267516.1 15673342 1115010 complement(1396604..1397011) 1 NC_002662.1 hypothetical protein 1397011 ynjH 1115010 ynjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267516.1 1396604 R 272623 CDS NP_267517.1 15673343 1115011 complement(1397062..1397496) 1 NC_002662.1 hypothetical protein 1397496 ynjI 1115011 ynjI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267517.1 1397062 R 272623 CDS NP_267518.1 15673344 1115012 complement(1397509..1398090) 1 NC_002662.1 hypothetical protein 1398090 ynjJ 1115012 ynjJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267518.1 1397509 R 272623 CDS NP_267519.1 15673345 1115013 complement(1398287..1401481) 1 NC_002662.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1401481 carB 1115013 carB Lactococcus lactis subsp. lactis Il1403 carbamoyl phosphate synthase large subunit NP_267519.1 1398287 R 272623 CDS NP_267520.2 30024038 1115014 complement(1401793..1402266) 1 NC_002662.1 thioredoxin, glutaredoxin, and glutathione; cellular metabolism or defense processes; glutathione peroxidase 1402266 gpo 1115014 gpo Lactococcus lactis subsp. lactis Il1403 glutathione peroxidase NP_267520.2 1401793 R 272623 CDS NP_267521.1 15673347 1115015 1402449..1403078 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis; similar to Orf39 of Bacillus subtilis bacteriophage phi-105; N-acetylmuramidase 1403078 acmC 1115015 acmC Lactococcus lactis subsp. lactis Il1403 N-acetylmuramidase NP_267521.1 1402449 D 272623 CDS NP_267522.1 15673348 1115016 complement(1403120..1405756) 1 NC_002662.1 transort and binding protein, cations; cation-transporting ATPase 1405756 yoaB 1115016 yoaB Lactococcus lactis subsp. lactis Il1403 cation-transporting ATPase NP_267522.1 1403120 R 272623 CDS NP_267523.1 15673349 1115017 complement(1406014..1406739) 1 NC_002662.1 hypothetical protein 1406739 yoaD 1115017 yoaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267523.1 1406014 R 272623 CDS NP_267524.1 15673350 1115018 complement(1406957..1407526) 1 NC_002662.1 similar to a hydrophobic protein of Lactobacillus fermentum accession number U97348; hypothetical protein 1407526 yoaF 1115018 yoaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267524.1 1406957 R 272623 CDS NP_267525.1 15673351 1115019 complement(1407667..1408482) 1 NC_002662.1 hypothetical protein 1408482 yoaG 1115019 yoaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267525.1 1407667 R 272623 CDS NP_267526.1 15673352 1115020 1408993..1409535 1 NC_002662.1 similar to unknown protein MTH1490 of Methanobacterium thermoautotrophicum; hypothetical protein 1409535 yoaH 1115020 yoaH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267526.1 1408993 D 272623 CDS NP_267527.1 15673353 1115021 1409731..1410489 1 NC_002662.1 similar to hypothetical membrane protein LaaN; hypothetical protein 1410489 yoaI 1115021 yoaI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267527.1 1409731 D 272623 CDS NP_835318.1 30024039 1115022 complement(1410555..1410908) 1 NC_002662.1 hypothetical protein 1410908 1115022 L200054 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835318.1 1410555 R 272623 CDS NP_267528.1 15673354 1115023 complement(1411005..1411433) 1 NC_002662.1 hypothetical protein 1411433 yobA 1115023 yobA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267528.1 1411005 R 272623 CDS NP_267529.1 15673355 1115024 complement(1411744..1412145) 1 NC_002662.1 adaptations and atypical conditions; arsenate reductase 1412145 arsC 1115024 arsC Lactococcus lactis subsp. lactis Il1403 arsenate reductase NP_267529.1 1411744 R 272623 CDS NP_267530.1 15673356 1115025 1412261..1412443 1 NC_002662.1 hypothetical protein 1412443 yobC 1115025 yobC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267530.1 1412261 D 272623 CDS NP_267531.1 15673357 1115026 complement(1414112..1414642) 1 NC_002662.1 similar to orf258 of Lactococcus lactis phage BK5-T; prophage pi3 protein 01 1414642 pi301 1115026 pi301 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 01 NP_267531.1 1414112 R 272623 CDS NP_267532.1 15673358 1115027 1414831..1415064 1 NC_002662.1 prophage pi3 protein 02 1415064 pi302 1115027 pi302 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 02 NP_267532.1 1414831 D 272623 CDS NP_267533.1 15673359 1115028 complement(1415364..1415534) 1 NC_002662.1 prophage pi3 protein 03 1415534 pi303 1115028 pi303 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 03 NP_267533.1 1415364 R 272623 CDS NP_267534.1 15673360 1115029 1415811..1416014 1 NC_002662.1 prophage pi3 protein 04 1416014 pi304 1115029 pi304 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 04 NP_267534.1 1415811 D 272623 CDS NP_267535.1 15673361 1115030 complement(1416048..1416827) 1 NC_002662.1 prophage pi3 protein 05; similar to Orf259 of Lactococcus lactis phage BK5-T; muramidase 1416827 pi305 1115030 pi305 Lactococcus lactis subsp. lactis Il1403 muramidase NP_267535.1 1416048 R 272623 CDS NP_267536.1 15673362 1115031 complement(1416827..1417126) 1 NC_002662.1 prophage pi3 protein 06; similar to Orf95 of Lactococcus lactis phage BK5-T; holin 1417126 pi306 1115031 pi306 Lactococcus lactis subsp. lactis Il1403 holin NP_267536.1 1416827 R 272623 CDS NP_267537.1 15673363 1115032 complement(1417152..1418714) 1 NC_002662.1 similar to Orf47 of bacteriophage r1t; prophage pi3 protein 07 1418714 pi307 1115032 pi307 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 07 NP_267537.1 1417152 R 272623 CDS NP_267538.1 15673364 1115033 complement(1418726..1418950) 1 NC_002662.1 similar to Orf75 of Lactococcus lactis phage BK5-T; prophage pi3 protein 08 1418950 pi308 1115033 pi308 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 08 NP_267538.1 1418726 R 272623 CDS NP_267539.1 15673365 1115034 complement(1418970..1421402) 1 NC_002662.1 similar to Orf1904 of Lactococcus lactis phage BK5-T; prophage pi3 protein 09 1421402 pi309 1115034 pi309 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 09 NP_267539.1 1418970 R 272623 CDS NP_267540.1 15673366 1115035 complement(1421380..1421553) 1 NC_002662.1 similar to Orf44 of Streptococcus thermophilus bacteriophage phi o1205; prophage pi3 protein 10 1421553 pi310 1115035 pi310 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 10 NP_267540.1 1421380 R 272623 CDS NP_267541.1 15673367 1115036 complement(1421553..1422674) 1 NC_002662.1 similar to gp373 of Streptococcus thermophilus bacteriophage sfi11; prophage pi3 protein 11 1422674 pi311 1115036 pi311 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 11 NP_267541.1 1421553 R 272623 CDS NP_267542.1 15673368 1115037 complement(1422690..1424477) 1 NC_002662.1 similar to Orf1904 of Lactococcus lactis phage BK5-T; prophage pi3 protein 12 1424477 pi312 1115037 pi312 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 12 NP_267542.1 1422690 R 272623 CDS NP_267543.1 15673369 1115038 complement(1424477..1426012) 1 NC_002662.1 tail component; similar to tail component protein Orf17 of Streptococcus thermophilus bacteriophage DT1; prophage pi3 protein 13 1426012 pi313 1115038 pi313 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 13 NP_267543.1 1424477 R 272623 CDS NP_267544.1 15673370 1115039 complement(1426015..1430937) 1 NC_002662.1 similar to minor capsid protein of Lactobacillus temperate phage phi g1e; prophage pi3 protein 14 1430937 pi314 1115039 pi314 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 14 NP_267544.1 1426015 R 272623 CDS NP_267545.1 15673371 1115040 complement(1431162..1431581) 1 NC_002662.1 tail component; similar to Orf14 encoding a tail component protein of Streptococcus thermophilus bacteriophage DT1; prophage pi3 protein 16 1431581 pi316 1115040 pi316 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 16 NP_267545.1 1431162 R 272623 CDS NP_267546.1 15673372 1115041 complement(1431726..1432319) 1 NC_002662.1 prophage pi3 protein 17; similar to major tail protein of Streptococcus thermophilus bacteriophage DT1; major tail protein 1432319 pi317 1115041 pi317 Lactococcus lactis subsp. lactis Il1403 major tail protein NP_267546.1 1431726 R 272623 CDS NP_267547.1 15673373 1115042 complement(1432350..1432745) 1 NC_002662.1 tail component; similar to Orf12 encoding a tail component protein of Streptococcus thermophilus bacteriophage DT1; prophage pi3 protein 18 1432745 pi318 1115042 pi318 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 18 NP_267547.1 1432350 R 272623 CDS NP_267548.1 15673374 1115043 complement(1432742..1433248) 1 NC_002662.1 tail component; similar to 18K protein of Leuconostoc oenos phage L10; prophage pi3 protein 19 1433248 pi319 1115043 pi319 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 19 NP_267548.1 1432742 R 272623 CDS NP_267549.1 15673375 1115044 complement(1433250..1433600) 1 NC_002662.1 prophage pi3 protein 20; similar to head-tail joining protein of Streptococcus thermophilus bacteriophage DT1; head-tail joining protein 1433600 pi320 1115044 pi320 Lactococcus lactis subsp. lactis Il1403 head-tail joining protein NP_267549.1 1433250 R 272623 CDS NP_267550.1 15673376 1115045 complement(1433575..1433898) 1 NC_002662.1 similar to a hypothetical protein of Lactococcus lactis phage BK5-T; prophage pi3 protein 21 1433898 pi321 1115045 pi321 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 21 NP_267550.1 1433575 R 272623 CDS NP_267551.1 15673377 1115046 complement(1433914..1435140) 1 NC_002662.1 prophage pi3 protein 22; similar to major head protein precursor of Streptococcus thermophilus bacteriophage Sfi21; major head protein precursor 1435140 pi322 1115046 pi322 Lactococcus lactis subsp. lactis Il1403 major head protein precursor NP_267551.1 1433914 R 272623 CDS NP_267552.1 15673378 1115047 complement(1435152..1435859) 1 NC_002662.1 prophage pi3 protein 23; ATP dependent Clp protease 1435859 pi323 1115047 pi323 Lactococcus lactis subsp. lactis Il1403 ATP dependent Clp protease NP_267552.1 1435152 R 272623 CDS NP_267553.1 15673379 1115048 complement(1435902..1437080) 1 NC_002662.1 similar to orf387 gp of Streptococcus thermophilus bacteriophage Sfi19; prophage pi3 protein 24 1437080 pi324 1115048 pi324 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 24 NP_267553.1 1435902 R 272623 CDS NP_267554.1 15673380 1115049 complement(1437077..1437286) 1 NC_002662.1 prophage pi3 protein 25; similar to head-tail joining protein of Streptococcus thermophilus bacteriophage DT1; head-tail joining protein 1437286 pi325 1115049 pi325 Lactococcus lactis subsp. lactis Il1403 head-tail joining protein NP_267554.1 1437077 R 272623 CDS NP_267555.1 15673381 1115050 complement(1437255..1439228) 1 NC_002662.1 prophage pi3 protein 26; similar to terminase large subunit of Streptococcus thermophilus bacteriophage Sfi21; terminase large subunit 1439228 pi326 1115050 pi326 Lactococcus lactis subsp. lactis Il1403 terminase large subunit NP_267555.1 1437255 R 272623 CDS NP_267556.1 15673382 1115051 complement(1439215..1439688) 1 NC_002662.1 prophage pi3 protein 27; similar to terminase small subunit of Streptococcus thermophilus bacteriophage Sfi21; terminase small subunit 1439688 pi327 1115051 pi327 Lactococcus lactis subsp. lactis Il1403 terminase small subunit NP_267556.1 1439215 R 272623 CDS NP_267557.1 15673383 1115052 complement(1439817..1440332) 1 NC_002662.1 similar to orf170 of Streptococcus thermophilus bacteriophage Sfi19; prophage pi3 protein 28 1440332 pi328 1115052 pi328 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 28 NP_267557.1 1439817 R 272623 CDS NP_267558.1 15673384 1115053 complement(1440334..1440639) 1 NC_002662.1 prophage pi3 protein 29 1440639 pi329 1115053 pi329 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 29 NP_267558.1 1440334 R 272623 CDS NP_267559.1 15673385 1115054 complement(1440787..1441209) 1 NC_002662.1 similar to a hypothetical protein of Lactococcus lactis accession number Y11901); prophage pi3 protein 30 1441209 pi330 1115054 pi330 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 30 NP_267559.1 1440787 R 272623 CDS NP_267560.1 15673386 1115055 complement(1441287..1441646) 1 NC_002662.1 prophage pi3 protein 31 1441646 pi331 1115055 pi331 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 31 NP_267560.1 1441287 R 272623 CDS NP_835319.1 30024040 1115056 complement(1441771..1441926) 1 NC_002662.1 similar to bacteriophage bIL286 Orf34; hypothetical protein 1441926 1115056 L200055 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835319.1 1441771 R 272623 CDS NP_835320.1 30024041 1115057 complement(1441934..1442041) 1 NC_002662.1 hypothetical protein 1442041 1115057 L200056 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835320.1 1441934 R 272623 CDS NP_267561.1 15673387 1115058 complement(1442107..1442301) 1 NC_002662.1 similar to orfX of bacteriophage 712 accession number AF087814; prophage pi3 protein 32 1442301 pi332 1115058 pi332 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 32 NP_267561.1 1442107 R 272623 CDS NP_835321.1 30024042 1115059 complement(1442298..1442441) 1 NC_002662.1 similar to bacteriophage bIL309 Orf27; hypothetical protein 1442441 1115059 L200057 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835321.1 1442298 R 272623 CDS NP_267562.1 15673388 1115060 complement(1442460..1442795) 1 NC_002662.1 similar to Orf29 of the Lactococcus lactis lytic bacteriophage sk1; prophage pi3 protein 33 1442795 pi333 1115060 pi333 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 33 NP_267562.1 1442460 R 272623 CDS NP_267563.1 15673389 1115061 complement(1442817..1443161) 1 NC_002662.1 similar to Orf21 of bacteriophage r1t; prophage pi3 protein 34 1443161 pi334 1115061 pi334 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 34 NP_267563.1 1442817 R 272623 CDS NP_267564.1 15673390 1115062 complement(1443165..1443584) 1 NC_002662.1 prophage pi3 protein 35; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t; deoxyuridine 5'-triphosphate nucleotidohydrolase 1443584 pi335 1115062 pi335 Lactococcus lactis subsp. lactis Il1403 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_267564.1 1443165 R 272623 CDS NP_267565.1 15673391 1115063 complement(1443581..1443868) 1 NC_002662.1 prophage pi3 protein 36 1443868 pi336 1115063 pi336 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 36 NP_267565.1 1443581 R 272623 CDS NP_267566.1 15673392 1115064 complement(1443865..1444521) 1 NC_002662.1 similar to Orf19 of bacteriophage r1t; prophage pi3 protein 37 1444521 pi337 1115064 pi337 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 37 NP_267566.1 1443865 R 272623 CDS NP_267567.1 15673393 1115065 complement(1444493..1444852) 1 NC_002662.1 similar to hypothetical protein 2 of bacteriophage T5; prophage pi3 protein 38 1444852 pi338 1115065 pi338 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 38 NP_267567.1 1444493 R 272623 CDS NP_267568.1 15673394 1115066 complement(1444861..1445370) 1 NC_002662.1 prophage pi3 protein 39 1445370 pi339 1115066 pi339 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 39 NP_267568.1 1444861 R 272623 CDS NP_267569.1 15673395 1115067 complement(1445385..1445957) 1 NC_002662.1 similar to Orf18 of bacteriophage r1t; prophage pi3 protein 40 1445957 pi340 1115067 pi340 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 40 NP_267569.1 1445385 R 272623 CDS NP_267570.1 15673396 1115068 complement(1445947..1446126) 1 NC_002662.1 similar to Orf17 of bacteriophage r1t; prophage pi3 protein 41 1446126 pi341 1115068 pi341 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 41 NP_267570.1 1445947 R 272623 CDS NP_267571.1 15673397 1115069 complement(1446148..1446438) 1 NC_002662.1 prophage pi3 protein 42 1446438 pi342 1115069 pi342 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 42 NP_267571.1 1446148 R 272623 CDS NP_267572.1 15673398 1115070 complement(1446550..1446789) 1 NC_002662.1 similar to Orf16 of bacteriophage r1t; prophage pi3 protein 43 1446789 pi343 1115070 pi343 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 43 NP_267572.1 1446550 R 272623 CDS NP_267573.1 15673399 1115071 complement(1446782..1447276) 1 NC_002662.1 similar to Orf15 of bacteriophage r1t; prophage pi3 protein 44 1447276 pi344 1115071 pi344 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 44 NP_267573.1 1446782 R 272623 CDS NP_267574.1 15673400 1115072 complement(1447273..1447647) 1 NC_002662.1 prophage pi3 protein 45 1447647 pi345 1115072 pi345 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 45 NP_267574.1 1447273 R 272623 CDS NP_835322.1 30024043 1115073 complement(1447628..1447801) 1 NC_002662.1 hypothetical protein 1447801 1115073 L200058 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835322.1 1447628 R 272623 CDS NP_267575.1 15673401 1115074 complement(1447798..1448682) 1 NC_002662.1 prophage pi3 protein 46; similar to the orf12 of the phage r1t; similar to DnaC of Escherichia coli or DnaI of Bacillus subtilis, which are required for chromosomal replication; DNA replication protein 1448682 pi346 1115074 pi346 Lactococcus lactis subsp. lactis Il1403 DNA replication protein NP_267575.1 1447798 R 272623 CDS NP_267576.1 15673402 1115075 complement(1448692..1449531) 1 NC_002662.1 prophage pi3 protein 47; similar to Rep2009 of bacteriophage Tuc2009; replisome organizer protein 1449531 pi347 1115075 pi347 Lactococcus lactis subsp. lactis Il1403 replisome organizer protein NP_267576.1 1448692 R 272623 CDS NP_267577.1 15673403 1115076 complement(1449659..1450084) 1 NC_002662.1 prophage pi3 protein 48; single strand binding helix destabilising protein 1450084 pi348 1115076 pi348 Lactococcus lactis subsp. lactis Il1403 single strand binding helix destabilising protein NP_267577.1 1449659 R 272623 CDS NP_267578.1 15673404 1115077 complement(1450077..1450835) 1 NC_002662.1 prophage pi3 protein 49 1450835 pi349 1115077 pi349 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 49 NP_267578.1 1450077 R 272623 CDS NP_267579.1 15673405 1115078 complement(1450844..1451239) 1 NC_002662.1 similar to Orf10 of bacteriophage TP901-1; prophage pi3 protein 50 1451239 pi350 1115078 pi350 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 50 NP_267579.1 1450844 R 272623 CDS NP_267580.1 15673406 1115079 complement(1451354..1451569) 1 NC_002662.1 similar to Orf71 of Lactococcus bacteriophage phi31; prophage pi3 protein 51 1451569 pi351 1115079 pi351 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 51 NP_267580.1 1451354 R 272623 CDS NP_267581.1 15673407 1115080 1451672..1451947 1 NC_002662.1 similar to Orf10 of bacteriophage Tuc2009; prophage pi3 protein 52 1451947 pi352 1115080 pi352 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 52 NP_267581.1 1451672 D 272623 CDS NP_267582.1 15673408 1115081 complement(1451944..1452138) 1 NC_002662.1 similar to Orf113 of Lactococcus lactis phage BK5-T; prophage pi3 protein 53 1452138 pi353 1115081 pi353 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 53 NP_267582.1 1451944 R 272623 CDS NP_267583.1 15673409 1115082 complement(1452281..1452571) 1 NC_002662.1 prophage pi3 protein 54 1452571 pi354 1115082 pi354 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 54 NP_267583.1 1452281 R 272623 CDS NP_267584.1 15673410 1115083 complement(1452584..1453294) 1 NC_002662.1 prophage pi3 protein 55; similar to P1-antirepressor homolog of Streptococcus thermophilus bacteriophage TP-J34; antirepressor 1453294 pi355 1115083 pi355 Lactococcus lactis subsp. lactis Il1403 antirepressor NP_267584.1 1452584 R 272623 CDS NP_267585.1 15673411 1115084 complement(1453308..1453547) 1 NC_002662.1 prophage pi3 protein 56; similar to cro-like repressor of Streptococcus thermophilus bacteriophage Sfi21; Cro-like repressor 1453547 pi356 1115084 pi356 Lactococcus lactis subsp. lactis Il1403 Cro-like repressor NP_267585.1 1453308 R 272623 CDS NP_267586.1 15673412 1115085 1453713..1454234 1 NC_002662.1 prophage pi3 protein 57; similar to repressor of Lactobacillus casei bacteriophage A2; cI-like repressor 1454234 pi357 1115085 pi357 Lactococcus lactis subsp. lactis Il1403 cI-like repressor NP_267586.1 1453713 D 272623 CDS NP_267587.1 15673413 1115086 1454244..1454831 1 NC_002662.1 prophage pi3 protein 58 1454831 pi358 1115086 pi358 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 58 NP_267587.1 1454244 D 272623 CDS NP_267588.1 15673414 1115087 1454896..1455747 1 NC_002662.1 prophage pi3 protein 59 1455747 pi359 1115087 pi359 Lactococcus lactis subsp. lactis Il1403 prophage pi3 protein 59 NP_267588.1 1454896 D 272623 CDS NP_267589.1 15673415 1115088 1455870..1456949 1 NC_002662.1 prophage pi3 protein 60; integrase 1456949 pi360 1115088 pi360 Lactococcus lactis subsp. lactis Il1403 integrase NP_267589.1 1455870 D 272623 CDS NP_267590.1 15673416 1115089 complement(1457654..1457989) 1 NC_002662.1 similar to YlxM of Bacillus subtilis; DNA-binding protein 1457989 yofM 1115089 yofM Lactococcus lactis subsp. lactis Il1403 DNA-binding protein NP_267590.1 1457654 R 272623 CDS NP_267591.1 15673417 1115090 1458173..1458883 1 NC_002662.1 evidence experimental PMID:10708382; two-component systems; two-component system regulator 1458883 llrB 1115090 llrB Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267591.1 1458173 D 272623 CDS NP_267592.1 15673418 1115091 1458873..1460426 1 NC_002662.1 evidence experimental PMID:9172368; two-component systems; sensor protein kinase 1460426 kinB 1115091 kinB Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267592.1 1458873 D 272623 CDS NP_835323.1 30024044 1115092 1460604..1460966 1 NC_002662.1 similar to Lactococcus lactis TcsBorf2; in the same operon as lrrB and kinB; hypothetical protein 1460966 yogA 1115092 yogA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835323.1 1460604 D 272623 CDS NP_267593.1 15673419 1115093 complement(1460974..1461681) 1 NC_002662.1 GntR-family regulator; probably ranscriptional regulator of acetyl-CoA synthesis (by the vicinity of corresponding genes); GntR family transcriptional regulator 1461681 rgrB 1115093 rgrB Lactococcus lactis subsp. lactis Il1403 GntR family transcriptional regulator NP_267593.1 1460974 R 272623 CDS NP_267594.1 15673420 1115094 complement(1461873..1462925) 1 NC_002662.1 membranes, lipoproteins, and porins; attached to membrane by a lipid anchor; BMP family of lipoproteins; basic membrane protein A 1462925 bmpA 1115094 bmpA Lactococcus lactis subsp. lactis Il1403 basic membrane protein A NP_267594.1 1461873 R 272623 CDS NP_267595.1 15673421 1115095 complement(1463184..1463576) 1 NC_002662.1 salvage of nucleosides and nucleotides; cytidine deaminase 1463576 cdd 1115095 cdd Lactococcus lactis subsp. lactis Il1403 cytidine deaminase NP_267595.1 1463184 R 272623 CDS NP_267596.1 15673422 1115096 complement(1463563..1464225) 1 NC_002662.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1464225 deoC 1115096 deoC Lactococcus lactis subsp. lactis Il1403 deoxyribose-phosphate aldolase NP_267596.1 1463563 R 272623 CDS NP_267597.1 15673423 1115097 complement(1464238..1464426) 1 NC_002662.1 hypothetical protein 1464426 yogE 1115097 yogE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267597.1 1464238 R 272623 CDS NP_267598.1 15673424 1115098 complement(1464428..1465720) 1 NC_002662.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 1465720 pdp 1115098 pdp Lactococcus lactis subsp. lactis Il1403 pyrimidine-nucleoside phosphorylase NP_267598.1 1464428 R 272623 CDS NP_267599.1 15673425 1115099 complement(1465751..1466353) 1 NC_002662.1 SAM-dependent methyltransferase, evidenced by COGnitor; hypothetical protein 1466353 yogG 1115099 yogG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267599.1 1465751 R 272623 CDS NP_267600.1 15673426 1115100 1466541..1467461 1 NC_002662.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1467461 coaA 1115100 coaA Lactococcus lactis subsp. lactis Il1403 pantothenate kinase NP_267600.1 1466541 D 272623 CDS NP_267601.1 15673427 1115101 complement(1467528..1467959) 1 NC_002662.1 phosphate-starvation-inducible protein PsiE 1467959 yogI 1115101 yogI Lactococcus lactis subsp. lactis Il1403 phosphate-starvation-inducible protein PsiE NP_267601.1 1467528 R 272623 CDS NP_267602.1 15673428 1115102 complement(1468013..1468957) 1 NC_002662.1 transort and binding protein, cations; cation transporter 1468957 yogJ 1115102 yogJ Lactococcus lactis subsp. lactis Il1403 cation transporter NP_267602.1 1468013 R 272623 CDS NP_267603.1 15673429 1115103 complement(1469252..1469554) 1 NC_002662.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000; transcriptional regulator 1469554 yogL 1115103 yogL Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267603.1 1469252 R 272623 CDS NP_267604.1 15673430 1115104 complement(1469635..1470177) 1 NC_002662.1 hypothetical protein 1470177 yogM 1115104 yogM Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267604.1 1469635 R 272623 CDS NP_267605.1 15673431 1115106 1471753..1472319 1 NC_002662.1 belongs to TetR/AcrR family; transcriptional regulator 1472319 yohC 1115106 yohC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267605.1 1471753 D 272623 CDS NP_267606.1 15673432 1115107 complement(1472367..1472537) 1 NC_002662.1 hypothetical protein 1472537 yohD 1115107 yohD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267606.1 1472367 R 272623 CDS NP_267607.1 15673433 1115108 complement(1472729..1474450) 1 NC_002662.1 evidence experimental PMID:10515910; transport and binding protein; amino acids, peptides and amines. involved in osmoprotection. Permease and substrate binding functions are in the same protein; betaine ABC transporter permease and substrate binding protein 1474450 busAB 1115108 busAB Lactococcus lactis subsp. lactis Il1403 betaine ABC transporter permease and substrate binding protein NP_267607.1 1472729 R 272623 CDS NP_267608.1 15673434 1115109 complement(1474447..1475673) 1 NC_002662.1 evidence experimental PMID:10515910; transport and binding protein; amino acids, peptides and amines. involved in osmoprotection; betaine ABC transporter ATP binding protein 1475673 busAA 1115109 busAA Lactococcus lactis subsp. lactis Il1403 betaine ABC transporter ATP binding protein NP_267608.1 1474447 R 272623 CDS NP_267609.1 15673435 1115110 complement(1475885..1476505) 1 NC_002662.1 GntR-family regulators; similar to fatty acid responsive regulator of Escherichia coli; probably an osmotic shock responce regulator from vicinity of corresponding genes; GntR family transcriptional regulator 1476505 busR 1115110 busR Lactococcus lactis subsp. lactis Il1403 GntR family transcriptional regulator NP_267609.1 1475885 R 272623 CDS NP_267610.1 15673436 1115111 complement(1476721..1478346) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; lipopolysaccharide biosynthesis protein 1478346 yohH 1115111 yohH Lactococcus lactis subsp. lactis Il1403 lipopolysaccharide biosynthesis protein NP_267610.1 1476721 R 272623 CDS NP_267611.1 15673437 1115112 complement(1478370..1479890) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; lipopolysaccharide biosynthesis protein 1479890 yohJ 1115112 yohJ Lactococcus lactis subsp. lactis Il1403 lipopolysaccharide biosynthesis protein NP_267611.1 1478370 R 272623 CDS NP_267612.1 15673438 1115113 complement(1479930..1483202) 1 NC_002662.1 hypothetical protein 1483202 yoiA 1115113 yoiA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267612.1 1479930 R 272623 CDS NP_267613.1 15673439 1115114 complement(1483349..1484296) 1 NC_002662.1 hypothetical protein 1484296 yoiB 1115114 yoiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267613.1 1483349 R 272623 CDS NP_267614.1 15673440 1115115 complement(1484512..1488837) 1 NC_002662.1 hypothetical protein 1488837 yoiC 1115115 yoiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267614.1 1484512 R 272623 CDS NP_267615.1 15673441 1115116 complement(1489446..1490882) 1 NC_002662.1 energy metabolism, sugars; beta-glucosidase 1490882 bglH 1115116 bglH Lactococcus lactis subsp. lactis Il1403 beta-glucosidase NP_267615.1 1489446 R 272623 CDS NP_267616.1 15673442 1115117 complement(1490930..1492840) 1 NC_002662.1 transport and binding protein; PTS system; PTS system beta-glucoside-specific transporter subunit IIABC 1492840 ptbA 1115117 ptbA Lactococcus lactis subsp. lactis Il1403 PTS system beta-glucoside-specific transporter subunit IIABC NP_267616.1 1490930 R 272623 CDS NP_267617.1 15673443 1115118 complement(1492982..1493791) 1 NC_002662.1 evidence experimental PMID:8083160; BglG-family regulator; beta-glucoside operon antiterminator 1493791 bglR 1115118 bglR Lactococcus lactis subsp. lactis Il1403 beta-glucoside operon antiterminator NP_267617.1 1492982 R 272623 CDS NP_267618.1 15673444 1115119 complement(1493956..1494717) 1 NC_002662.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1494717 trpA 1115119 trpA Lactococcus lactis subsp. lactis Il1403 tryptophan synthase subunit alpha NP_267618.1 1493956 R 272623 CDS NP_267619.1 15673445 1115120 complement(1494714..1495922) 1 NC_002662.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1495922 trpB 1115120 trpB Lactococcus lactis subsp. lactis Il1403 tryptophan synthase subunit beta NP_267619.1 1494714 R 272623 CDS NP_267622.1 15673448 1115123 complement(1496508..1497563) 1 NC_002662.1 evidence experimental PMID:1400208; aromatic amino-acid family; phosphorybosyl-anthranilate isomerase 1497563 trpF 1115123 trpF Lactococcus lactis subsp. lactis Il1403 phosphorybosyl-anthranilate isomerase NP_267622.1 1496508 R 272623 CDS NP_267623.1 15673449 1115124 complement(1497553..1498347) 1 NC_002662.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; Indole-3-glycerol phosphate synthase 1498347 trpC 1115124 trpC Lactococcus lactis subsp. lactis Il1403 Indole-3-glycerol phosphate synthase NP_267623.1 1497553 R 272623 CDS NP_267624.2 30024045 1115125 complement(1498394..1499401) 1 NC_002662.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1499401 trpD 1115125 trpD Lactococcus lactis subsp. lactis Il1403 anthranilate phosphoribosyltransferase NP_267624.2 1498394 R 272623 CDS NP_267625.1 15673451 1115126 complement(1499391..1499987) 1 NC_002662.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1499987 trpG 1115126 trpG Lactococcus lactis subsp. lactis Il1403 anthranilate synthase component II NP_267625.1 1499391 R 272623 CDS NP_267626.1 15673452 1115127 complement(1500112..1501482) 1 NC_002662.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1501482 trpE 1115127 trpE Lactococcus lactis subsp. lactis Il1403 anthranilate synthase component I NP_267626.1 1500112 R 272623 CDS NP_267627.1 15673453 1115128 complement(1501940..1502299) 1 NC_002662.1 hypothetical protein 1502299 ypaA 1115128 ypaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267627.1 1501940 R 272623 CDS NP_267628.1 15673454 1115129 complement(1502314..1503384) 1 NC_002662.1 MarR-family regulator; N-terminal part similar to the MarR family of transcription regulators; C-terminal part similar to NAD(P)H nitroreductases; transcriptional regulator 1503384 rmaC 1115129 rmaC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267628.1 1502314 R 272623 CDS NP_267629.1 15673455 1115130 complement(1503498..1504241) 1 NC_002662.1 SAM-dependent methyltransferase, evidenced by COGnitor; hypothetical protein 1504241 ypaC 1115130 ypaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267629.1 1503498 R 272623 CDS NP_267630.1 15673456 1115131 complement(1504317..1504997) 1 NC_002662.1 hypothetical protein 1504997 ypaD 1115131 ypaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267630.1 1504317 R 272623 CDS NP_267631.1 15673457 1115132 complement(1504997..1505686) 1 NC_002662.1 hypothetical protein 1505686 ypaE 1115132 ypaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267631.1 1504997 R 272623 CDS NP_267632.1 15673458 1115133 1505812..1506198 1 NC_002662.1 general regulatory function; ferric uptake regulator 1506198 fur 1115133 fur Lactococcus lactis subsp. lactis Il1403 ferric uptake regulator NP_267632.1 1505812 D 272623 CDS NP_267633.1 15673459 1115134 1506344..1506691 1 NC_002662.1 hypothetical protein 1506691 ypaG 1115134 ypaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267633.1 1506344 D 272623 CDS NP_267634.1 15673460 1115135 1506887..1507774 1 NC_002662.1 hypothetical protein 1507774 ypaH 1115135 ypaH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267634.1 1506887 D 272623 CDS NP_267635.1 15673461 1115136 complement(1507815..1508249) 1 NC_002662.1 MerR family of transcription regulators; transcriptional regulator 1508249 rmeB 1115136 rmeB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267635.1 1507815 R 272623 CDS NP_267636.2 30024046 1115137 1508326..1509057 1 NC_002662.1 aerobic energy metabolism; short-chain dehydrogenase, evidenced by COGnitor; oxidoreductase 1509057 ypaI 1115137 ypaI Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267636.2 1508326 D 272623 CDS NP_267637.1 15673463 1115138 complement(1509163..1510962) 1 NC_002662.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1510962 dxsA 1115138 dxsA Lactococcus lactis subsp. lactis Il1403 1-deoxy-D-xylulose-5-phosphate synthase NP_267637.1 1509163 R 272623 CDS NP_267638.1 15673464 1115139 complement(1511212..1511631) 1 NC_002662.1 MarR-family regulator; MarR family transcriptional regulator 1511631 rmaE 1115139 rmaE Lactococcus lactis subsp. lactis Il1403 MarR family transcriptional regulator NP_267638.1 1511212 R 272623 CDS NP_267639.1 15673465 1115140 1511813..1512718 1 NC_002662.1 transport and binding protein, cations; similar to several magnesium and cobalt transporters; cationic transporter 1512718 ypbB 1115140 ypbB Lactococcus lactis subsp. lactis Il1403 cationic transporter NP_267639.1 1511813 D 272623 CDS NP_267640.1 15673466 1115141 1512823..1514202 1 NC_002662.1 hypothetical protein 1514202 ypbC 1115141 ypbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267640.1 1512823 D 272623 CDS NP_267641.1 15673467 1115142 complement(1514246..1515991) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar transport symporter 1515991 ypbD 1115142 ypbD Lactococcus lactis subsp. lactis Il1403 sugar transport symporter NP_267641.1 1514246 R 272623 CDS NP_267642.1 15673468 1115143 complement(1516220..1517761) 1 NC_002662.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1517761 guaA 1115143 guaA Lactococcus lactis subsp. lactis Il1403 GMP synthase NP_267642.1 1516220 R 272623 CDS NP_267643.1 15673469 1115144 complement(1517970..1518845) 1 NC_002662.1 energy metabolism, sugars; similar to the sacK encoded fructokinase of Lactococcus lactis cremoris NZ9800; fructokinase 1518845 scrK 1115144 scrK Lactococcus lactis subsp. lactis Il1403 fructokinase NP_267643.1 1517970 R 272623 CDS NP_267644.1 15673470 1115145 complement(1518948..1519829) 1 NC_002662.1 energy metabolism, sugars; similar to different sugar kinases; sugar kinase 1519829 ypbG 1115145 ypbG Lactococcus lactis subsp. lactis Il1403 sugar kinase NP_267644.1 1518948 R 272623 CDS NP_267645.1 15673471 1115146 complement(1519866..1521293) 1 NC_002662.1 energy metabolism, sugars; cellulose degradation pathway; beta-glucosidase 1521293 ypcA 1115146 ypcA Lactococcus lactis subsp. lactis Il1403 beta-glucosidase NP_267645.1 1519866 R 272623 CDS NP_267646.1 15673472 1115147 complement(1521323..1521931) 1 NC_002662.1 hypothetical protein 1521931 ypcB 1115147 ypcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267646.1 1521323 R 272623 CDS NP_267649.1 15673475 1115150 complement(1524880..1526427) 1 NC_002662.1 degradation of polysaccharides; alpha 1-6-glucosidase 1526427 dexB 1115150 dexB Lactococcus lactis subsp. lactis Il1403 alpha 1-6-glucosidase NP_267649.1 1524880 R 272623 CDS NP_267650.1 15673476 1115151 complement(1526420..1527397) 1 NC_002662.1 degradation of polysaccharides; similar to lacto-N-biosidase precursor of Streptomyces sp, the enzyme, which releases lacto-N-biose from oligosaccharides; lacto-N-biosidase 1527397 lnbA 1115151 lnbA Lactococcus lactis subsp. lactis Il1403 lacto-N-biosidase NP_267650.1 1526420 R 272623 CDS NP_267651.1 15673477 1115152 complement(1527475..1528926) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; attached to the membrance by a lipid anchor; sugar ABC transporter substrate binding protein 1528926 ypcG 1115152 ypcG Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter substrate binding protein NP_267651.1 1527475 R 272623 CDS NP_267652.1 15673478 1115153 complement(1529029..1529949) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar ABC transporter permease 1529949 ypcH 1115153 ypcH Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter permease NP_267652.1 1529029 R 272623 CDS NP_267653.1 15673479 1115154 complement(1530005..1530937) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; sugar ABC transporter substrate binding protein 1530937 ypdA 1115154 ypdA Lactococcus lactis subsp. lactis Il1403 sugar ABC transporter substrate binding protein NP_267653.1 1530005 R 272623 CDS NP_267654.1 15673480 1115155 complement(1530934..1533633) 1 NC_002662.1 similar to different alpha-mannosidases; sugar hydrolase 1533633 ypdB 1115155 ypdB Lactococcus lactis subsp. lactis Il1403 sugar hydrolase NP_267654.1 1530934 R 272623 CDS NP_267655.1 15673481 1115156 complement(1533668..1534963) 1 NC_002662.1 hypothetical protein 1534963 ypdC 1115156 ypdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267655.1 1533668 R 272623 CDS NP_267656.1 15673482 1115157 1535202..1536239 1 NC_002662.1 LacI-family regulators; regulator of a polysacharide utilization operon. Highest similarity to L-arabinose utilization regulators from bacilli; transcriptional regulator 1536239 rliB 1115157 rliB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267656.1 1535202 D 272623 CDS NP_267657.1 15673483 1115158 1536236..1538389 1 NC_002662.1 sugars; similar to alpha-1,2-mannosidase of Bacillus sp. M-90; sugar hydrolase 1538389 ypdD 1115158 ypdD Lactococcus lactis subsp. lactis Il1403 sugar hydrolase NP_267657.1 1536236 D 272623 CDS NP_267658.1 15673484 1115159 complement(1538482..1540950) 1 NC_002662.1 phosphoketolase 1540950 ptk 1115159 ptk Lactococcus lactis subsp. lactis Il1403 phosphoketolase NP_267658.1 1538482 R 272623 CDS NP_267659.1 15673485 1115160 complement(1541108..1542409) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; D-xylose proton-symporter 1542409 xylT 1115160 xylT Lactococcus lactis subsp. lactis Il1403 D-xylose proton-symporter NP_267659.1 1541108 R 272623 CDS NP_267660.1 15673486 1115161 complement(1542578..1543180) 1 NC_002662.1 sugars; acetyltransferase in xylose utilization operon; acetyltransferase 1543180 xylX 1115161 xylX Lactococcus lactis subsp. lactis Il1403 acetyltransferase NP_267660.1 1542578 R 272623 CDS NP_267661.1 15673487 1115162 complement(1543238..1544917) 1 NC_002662.1 sugars; intracellular xylan-degrading enzyme; beta-1,4-xylosidase 1544917 xynB 1115162 xynB Lactococcus lactis subsp. lactis Il1403 beta-1,4-xylosidase NP_267661.1 1543238 R 272623 CDS NP_267662.2 30024047 1115163 complement(1544942..1546426) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; xylose utilization; sodium:galactosidase symporter family; xyloside transporter 1546426 xynT 1115163 xynT Lactococcus lactis subsp. lactis Il1403 xyloside transporter NP_267662.2 1544942 R 272623 CDS NP_267663.1 15673489 1115164 complement(1546480..1547484) 1 NC_002662.1 sugars; xylose utilization; may act on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; aldose 1-epimerase 1547484 xylM 1115164 xylM Lactococcus lactis subsp. lactis Il1403 aldose 1-epimerase NP_267663.1 1546480 R 272623 CDS NP_267664.1 15673490 1115165 complement(1547487..1548992) 1 NC_002662.1 sugars; xylose utilization; xylulose kinase 1548992 xylB 1115165 xylB Lactococcus lactis subsp. lactis Il1403 xylulose kinase NP_267664.1 1547487 R 272623 CDS NP_267665.1 15673491 1115166 complement(1549053..1550372) 1 NC_002662.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1550372 xylA 1115166 xylA Lactococcus lactis subsp. lactis Il1403 xylose isomerase NP_267665.1 1549053 R 272623 CDS NP_267666.1 15673492 1115167 1550477..1551460 1 NC_002662.1 AraC-family regulators; xylose operon regulator 1551460 xylR 1115167 xylR Lactococcus lactis subsp. lactis Il1403 xylose operon regulator NP_267666.1 1550477 D 272623 CDS NP_267667.1 15673493 1115168 complement(1551581..1552630) 1 NC_002662.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1552630 purK 1115168 purK Lactococcus lactis subsp. lactis Il1403 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_267667.1 1551581 R 272623 CDS NP_267668.1 15673494 1115169 complement(1552738..1553223) 1 NC_002662.1 evidence experimental PMID:9797284; catalytic subunit; sixth step in de novo purine biosynthesis; phosphoribosylaminoimidazole carboxylase 1553223 purE 1115169 purE Lactococcus lactis subsp. lactis Il1403 phosphoribosylaminoimidazole carboxylase NP_267668.1 1552738 R 272623 CDS NP_267669.1 15673495 1115170 complement(1553256..1554497) 1 NC_002662.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1554497 purD 1115170 purD Lactococcus lactis subsp. lactis Il1403 phosphoribosylamine--glycine ligase NP_267669.1 1553256 R 272623 CDS NP_267670.1 15673496 1115171 1554850..1555476 1 NC_002662.1 TerR/AcrR family; transcriptional regulator 1555476 ypfD 1115171 ypfD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267670.1 1554850 D 272623 CDS NP_267671.1 15673497 1115172 1555588..1556535 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983F 1556535 tra983F 1115172 tra983F Lactococcus lactis subsp. lactis Il1403 transposase of IS983F NP_267671.1 1555588 D 272623 CDS NP_267672.1 15673498 1115173 1556660..1558048 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to many multidrug resistance transporters; transporter 1558048 ypfE 1115173 ypfE Lactococcus lactis subsp. lactis Il1403 transporter NP_267672.1 1556660 D 272623 CDS NP_267673.1 15673499 1115174 complement(1558092..1558784) 1 NC_002662.1 similar to a hypothetical protein YfnB of Bacillus subtilis; hypothetical protein 1558784 ypfF 1115174 ypfF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267673.1 1558092 R 272623 CDS NP_267674.1 15673500 1115175 complement(1558961..1560517) 1 NC_002662.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1560517 purH 1115175 purH Lactococcus lactis subsp. lactis Il1403 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_267674.1 1558961 R 272623 CDS NP_267675.1 15673501 1115176 complement(1560693..1561235) 1 NC_002662.1 purine biosynthesis or salvage; hypoxanthine-guanine phosphoribosyltransferase 1561235 hprT 1115176 hprT Lactococcus lactis subsp. lactis Il1403 hypoxanthine-guanine phosphoribosyltransferase NP_267675.1 1560693 R 272623 CDS NP_267676.1 15673502 1115177 complement(1561372..1562409) 1 NC_002662.1 aerobic energy metabolism; similar to many reductases involved in flavonoid metabolism in plants; nucleoside-diphosphate-sugar epimerase, evidenced by COGnitor; oxidoreductase 1562409 ypgB 1115177 ypgB Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267676.1 1561372 R 272623 CDS NP_267677.1 15673503 1115178 1562540..1563070 1 NC_002662.1 general regulatory function; transcriptional regulator 1563070 ypgC 1115178 ypgC Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267677.1 1562540 D 272623 CDS NP_267678.1 15673504 1115179 complement(1563121..1564710) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein/permease 1564710 ypgD 1115179 ypgD Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein/permease NP_267678.1 1563121 R 272623 CDS NP_267679.1 15673505 1115180 complement(1564877..1565425) 1 NC_002662.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1565425 purN 1115180 purN Lactococcus lactis subsp. lactis Il1403 phosphoribosylglycinamide formyltransferase NP_267679.1 1564877 R 272623 CDS NP_267680.1 15673506 1115181 complement(1565453..1566469) 1 NC_002662.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1566469 purM 1115181 purM Lactococcus lactis subsp. lactis Il1403 phosphoribosylaminoimidazole synthetase NP_267680.1 1565453 R 272623 CDS NP_267681.1 15673507 1115182 complement(1566658..1569261) 1 NC_002662.1 evidence experimental PMID:10094684; adaptations and atypical conditions; ATPase subunit of intracellular ATP-dependent protease; ClpB protein 1569261 clpB 1115182 clpB Lactococcus lactis subsp. lactis Il1403 ClpB protein NP_267681.1 1566658 R 272623 CDS NP_267682.1 15673508 1115183 1569495..1570835 1 NC_002662.1 hypothetical protein 1570835 ypgH 1115183 ypgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267682.1 1569495 D 272623 CDS NP_267683.1 15673509 1115184 complement(1570868..1571491) 1 NC_002662.1 aerobic energy metabolism; similar to NADH dehydrogenase of Aquifex aeolicus; NADH dehydrogenase 1571491 yphA 1115184 yphA Lactococcus lactis subsp. lactis Il1403 NADH dehydrogenase NP_267683.1 1570868 R 272623 CDS NP_267684.1 15673510 1115185 complement(1571601..1573100) 1 NC_002662.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1573100 purF 1115185 purF Lactococcus lactis subsp. lactis Il1403 amidophosphoribosyltransferase NP_267684.1 1571601 R 272623 CDS NP_267685.1 15673511 1115186 complement(1573215..1574060) 1 NC_002662.1 aerobic energy metabolism; similar to many hypothetical oxidoreductases; oxidoreductase 1574060 yphC 1115186 yphC Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267685.1 1573215 R 272623 CDS NP_267686.1 15673512 1115187 complement(1574172..1576391) 1 NC_002662.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 1576391 purL 1115187 purL Lactococcus lactis subsp. lactis Il1403 phosphoribosylformylglycinamidine synthase II NP_267686.1 1574172 R 272623 CDS NP_267687.1 15673513 1115188 complement(1576611..1577282) 1 NC_002662.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 1577282 purQ 1115188 purQ Lactococcus lactis subsp. lactis Il1403 phosphoribosylformylglycinamidine synthase I NP_267687.1 1576611 R 272623 CDS NP_267688.1 15673514 1115189 complement(1577282..1577545) 1 NC_002662.1 similar to YexA of Bacillus subtilis; hypothetical protein 1577545 yphF 1115189 yphF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267688.1 1577282 R 272623 CDS NP_267689.1 15673515 1115190 complement(1577601..1578311) 1 NC_002662.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 1578311 purC 1115190 purC Lactococcus lactis subsp. lactis Il1403 phosphoribosylaminoimidazolesuccinocarboxamide synthase NP_267689.1 1577601 R 272623 CDS NP_267690.1 15673516 1115191 complement(1578455..1578856) 1 NC_002662.1 similar to TM1010 of Thermotoga maritima; hypothetical protein 1578856 yphH 1115191 yphH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267690.1 1578455 R 272623 CDS NP_267691.1 15673517 1115192 complement(1578872..1579165) 1 NC_002662.1 hypothetical protein 1579165 yphI 1115192 yphI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267691.1 1578872 R 272623 CDS NP_267692.1 15673518 1115193 complement(1579184..1579492) 1 NC_002662.1 similar to C-terminal part of several 4-carboxymuconolactone decarboxylases; hypothetical protein 1579492 yphJ 1115193 yphJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267692.1 1579184 R 272623 CDS NP_267693.1 15673519 1115194 complement(1579528..1579896) 1 NC_002662.1 hypothetical protein 1579896 yphK 1115194 yphK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267693.1 1579528 R 272623 CDS NP_267694.1 15673520 1115195 complement(1579911..1580663) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1580663 ypiA 1115195 ypiA Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267694.1 1579911 R 272623 CDS NP_267695.1 15673521 1115196 complement(1580887..1582260) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to several multidrug resistance proteins; transporter 1582260 ypiB 1115196 ypiB Lactococcus lactis subsp. lactis Il1403 transporter NP_267695.1 1580887 R 272623 CDS NP_267696.1 15673522 1115197 complement(1582257..1582703) 1 NC_002662.1 MarR-family regulators; transcriptional regulator 1582703 rmaI 1115197 rmaI Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267696.1 1582257 R 272623 CDS NP_267697.1 15673523 1115198 complement(1582810..1583649) 1 NC_002662.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1583649 thyA 1115198 thyA Lactococcus lactis subsp. lactis Il1403 thymidylate synthase NP_267697.1 1582810 R 272623 CDS NP_267698.1 15673524 1115199 complement(1583745..1584197) 1 NC_002662.1 hypothetical protein 1584197 ypiE 1115199 ypiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267698.1 1583745 R 272623 CDS NP_267699.1 15673525 1115201 complement(1584827..1585399) 1 NC_002662.1 hypothetical protein 1585399 ypiH 1115201 ypiH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267699.1 1584827 R 272623 CDS NP_835324.1 30024048 1115202 complement(1585482..1585781) 1 NC_002662.1 hypothetical protein 1585781 1115202 L200062 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835324.1 1585482 R 272623 CDS NP_267700.1 15673526 1115203 complement(1585849..1586688) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981H 1586688 tra981H 1115203 tra981H Lactococcus lactis subsp. lactis Il1403 transposase of IS981H NP_267700.1 1585849 R 272623 CDS NP_267701.1 15673527 1115204 complement(1586700..1586960) 1 NC_002662.1 transposon related function; similar to orf1 of IS981; transposase 1586960 ypiI 1115204 ypiI Lactococcus lactis subsp. lactis Il1403 transposase NP_267701.1 1586700 R 272623 CDS NP_267702.1 15673528 1115205 complement(1586997..1587314) 1 NC_002662.1 hypothetical protein 1587314 ypiJ 1115205 ypiJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267702.1 1586997 R 272623 CDS NP_267703.1 15673529 1115206 complement(1587265..1587912) 1 NC_002662.1 hypothetical protein 1587912 ypiK 1115206 ypiK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267703.1 1587265 R 272623 CDS NP_267704.1 15673530 1115207 complement(1587916..1590348) 1 NC_002662.1 similar to YcdJ and YigE; hypothetical protein 1590348 ypiL 1115207 ypiL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267704.1 1587916 R 272623 CDS NP_267705.1 15673531 1115208 complement(1590528..1591574) 1 NC_002662.1 aerobic energy metabolism; similar to several alcohol dehydrogenases; dehydrogenase 1591574 ypjA 1115208 ypjA Lactococcus lactis subsp. lactis Il1403 dehydrogenase NP_267705.1 1590528 R 272623 CDS NP_267706.1 15673532 1115209 complement(1591686..1591955) 1 NC_002662.1 hypothetical protein 1591955 ypjB 1115209 ypjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267706.1 1591686 R 272623 CDS NP_267707.1 15673533 1115210 complement(1592015..1592722) 1 NC_002662.1 hypothetical protein 1592722 ypjC 1115210 ypjC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267707.1 1592015 R 272623 CDS NP_267708.1 15673534 1115211 complement(1592839..1593774) 1 NC_002662.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 1593774 pydA 1115211 pydA Lactococcus lactis subsp. lactis Il1403 dihydroorotate dehydrogenase 1A NP_267708.1 1592839 R 272623 CDS NP_267709.1 15673535 1115212 1593915..1594466 1 NC_002662.1 translation protein modification; involved in posttranslational protein modification; peptide methionine sulfoxide reductase 1594466 pmsX 1115212 pmsX Lactococcus lactis subsp. lactis Il1403 peptide methionine sulfoxide reductase NP_267709.1 1593915 D 272623 CDS NP_267710.1 15673536 1115213 complement(1594476..1595450) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1595450 ypjF 1115213 ypjF Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267710.1 1594476 R 272623 CDS NP_267711.1 15673537 1115214 complement(1595665..1597536) 1 NC_002662.1 transport and binding protein. contains two ATP binding domains; ABC transporter ATP-binding protein 1597536 ypjG 1115214 ypjG Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267711.1 1595665 R 272623 CDS NP_267712.1 15673538 1115216 complement(1598735..1599811) 1 NC_002662.1 aerobic energy metabolism; similar to several glycerol dehydrogenases; oxidoreductase 1599811 ypjH 1115216 ypjH Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267712.1 1598735 R 272623 CDS NP_267713.1 15673539 1115217 complement(1599914..1600459) 1 NC_002662.1 hypothetical protein 1600459 ypjI 1115217 ypjI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267713.1 1599914 R 272623 CDS NP_267714.1 15673540 1115218 complement(1600574..1601998) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; similar to dipeptidase PepD of Lactobacillus helveticus; dipeptidase 1601998 pepDB 1115218 pepDB Lactococcus lactis subsp. lactis Il1403 dipeptidase NP_267714.1 1600574 R 272623 CDS NP_267715.2 30024049 1115219 complement(1602114..1603310) 1 NC_002662.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1603310 papL 1115219 papL Lactococcus lactis subsp. lactis Il1403 tRNA CCA-pyrophosphorylase NP_267715.2 1602114 R 272623 CDS NP_267716.1 15673542 1115220 complement(1603530..1604066) 1 NC_002662.1 hypothetical protein 1604066 yqaB 1115220 yqaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267716.1 1603530 R 272623 CDS NP_267717.1 15673543 1115221 complement(1604115..1604897) 1 NC_002662.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1604897 dapB 1115221 dapB Lactococcus lactis subsp. lactis Il1403 dihydrodipicolinate reductase NP_267717.1 1604115 R 272623 CDS NP_267718.1 15673544 1115222 complement(1604998..1605843) 1 NC_002662.1 similar to DegV of Bacillus subtilis; hypothetical protein 1605843 yqaC 1115222 yqaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267718.1 1604998 R 272623 CDS NP_267719.1 15673545 1115223 complement(1605861..1606253) 1 NC_002662.1 hypothetical protein 1606253 yqaD 1115223 yqaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267719.1 1605861 R 272623 CDS NP_267720.2 30024050 1115224 complement(1606379..1607122) 1 NC_002662.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1607122 trmD 1115224 trmD Lactococcus lactis subsp. lactis Il1403 tRNA (guanine-N(1)-)-methyltransferase NP_267720.2 1606379 R 272623 CDS NP_267721.1 15673547 1115225 complement(1607127..1607642) 1 NC_002662.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1607642 rimM 1115225 rimM Lactococcus lactis subsp. lactis Il1403 16S rRNA-processing protein RimM NP_267721.1 1607127 R 272623 CDS NP_267722.1 15673548 1115226 complement(1607814..1608641) 1 NC_002662.1 probably hydrolase, lysophospholipase, evidenced by COGnitor; hypothetical protein 1608641 yqaG 1115226 yqaG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267722.1 1607814 R 272623 CDS NP_267723.1 15673549 1115227 complement(1608782..1609726) 1 NC_002662.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1609726 hemH 1115227 hemH Lactococcus lactis subsp. lactis Il1403 ferrochelatase NP_267723.1 1608782 R 272623 CDS NP_267724.1 15673550 1115228 complement(1609988..1610227) 1 NC_002662.1 hypothetical protein 1610227 yqbA 1115228 yqbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267724.1 1609988 R 272623 CDS NP_267725.1 15673551 1115229 complement(1610323..1610595) 1 NC_002662.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1610595 rpsP 1115229 rpsP Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S16 NP_267725.1 1610323 R 272623 CDS NP_267726.1 15673552 1115230 complement(1610684..1611916) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; hydroxymethylglutaryl-CoA reductase 1611916 mvaA 1115230 mvaA Lactococcus lactis subsp. lactis Il1403 hydroxymethylglutaryl-CoA reductase NP_267726.1 1610684 R 272623 CDS NP_267727.1 15673553 1115231 complement(1611996..1613135) 1 NC_002662.1 fatty acid and phospholipid metabolism; acetyl coenzyme A acetyltransferase 1613135 thiL 1115231 thiL Lactococcus lactis subsp. lactis Il1403 acetyl coenzyme A acetyltransferase NP_267727.1 1611996 R 272623 CDS NP_267728.1 15673554 1115232 1613444..1614598 1 NC_002662.1 fatty acid and phospholipid metabolism; potentially involved in some intermediate steps for the synthesis of a polyketide molecule which may be involved in secondary metabolism; hydroxymethylglutaryl-CoA synthase 1614598 hmcM 1115232 hmcM Lactococcus lactis subsp. lactis Il1403 hydroxymethylglutaryl-CoA synthase NP_267728.1 1613444 D 272623 CDS NP_267729.1 15673555 1115233 complement(1614659..1615366) 1 NC_002662.1 amino sugars; similar to glucosamine-6-P isomerase of Bacillus subtilis; glucosamine-6-P isomerase 1615366 nagB 1115233 nagB Lactococcus lactis subsp. lactis Il1403 glucosamine-6-P isomerase NP_267729.1 1614659 R 272623 CDS NP_267730.1 15673556 1115234 complement(1615518..1616480) 1 NC_002662.1 hypothetical protein 1616480 yqbF 1115234 yqbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267730.1 1615518 R 272623 CDS NP_267731.1 15673557 1115235 1616777..1617814 1 NC_002662.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1617814 queA 1115235 queA Lactococcus lactis subsp. lactis Il1403 S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_267731.1 1616777 D 272623 CDS NP_267732.1 15673558 1115236 complement(1617891..1618202) 1 NC_002662.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000; transcriptional regulator 1618202 yqbH 1115236 yqbH Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267732.1 1617891 R 272623 CDS NP_267735.1 15673561 1115239 complement(1619579..1624528) 1 NC_002662.1 similar to leucine-rich proteins; hypothetical protein 1624528 yqbK 1115239 yqbK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267735.1 1619579 R 272623 CDS NP_267736.1 15673562 1115240 complement(1624565..1625320) 1 NC_002662.1 hypothetical protein 1625320 yqcA 1115240 yqcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267736.1 1624565 R 272623 CDS NP_267737.1 15673563 1115241 complement(1625358..1626116) 1 NC_002662.1 hypothetical protein 1626116 yqcB 1115241 yqcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267737.1 1625358 R 272623 CDS NP_267738.1 15673564 1115242 complement(1626154..1626585) 1 NC_002662.1 hypothetical protein 1626585 yqcC 1115242 yqcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267738.1 1626154 R 272623 CDS NP_267739.1 15673565 1115243 complement(1626973..1627818) 1 NC_002662.1 hypothetical protein 1627818 yqcD 1115243 yqcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267739.1 1626973 R 272623 CDS NP_267740.1 15673566 1115244 complement(1627879..1627974) 1 NC_002662.1 hypothetical protein 1627974 yqcE 1115244 yqcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267740.1 1627879 R 272623 CDS NP_267741.1 15673567 1115245 1628791..1629408 1 NC_002662.1 hypothetical protein 1629408 yqcF 1115245 yqcF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267741.1 1628791 D 272623 CDS NP_267742.1 15673568 1115246 complement(1629422..1629592) 1 NC_002662.1 hypothetical protein 1629592 yqcG 1115246 yqcG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267742.1 1629422 R 272623 CDS NP_267743.2 161723237 1115247 complement(1629620..1630927) 1 NC_002662.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1630927 obgE 1115247 obgE Lactococcus lactis subsp. lactis Il1403 GTPase ObgE NP_267743.2 1629620 R 272623 CDS NP_267744.1 15673570 1115248 complement(1631083..1632261) 1 NC_002662.1 cell division protein; required for initiation of cell division; hypothetical protein 1632261 ftsQ 1115248 ftsQ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267744.1 1631083 R 272623 CDS NP_267745.1 15673571 1115249 complement(1632262..1633335) 1 NC_002662.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 1633335 murG 1115249 murG Lactococcus lactis subsp. lactis Il1403 UDP diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase NP_267745.1 1632262 R 272623 CDS NP_267746.1 15673572 1115250 complement(1633545..1634897) 1 NC_002662.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1634897 murD 1115250 murD Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_267746.1 1633545 R 272623 CDS NP_267747.1 15673573 1115251 complement(1635388..1635729) 1 NC_002662.1 nitrogen regulatory protein P-II 1635729 glnB 1115251 glnB Lactococcus lactis subsp. lactis Il1403 nitrogen regulatory protein P-II NP_267747.1 1635388 R 272623 CDS NP_267748.1 15673574 1115252 complement(1635861..1637102) 1 NC_002662.1 ammonium transporter 1637102 amtB 1115252 amtB Lactococcus lactis subsp. lactis Il1403 ammonium transporter NP_267748.1 1635861 R 272623 CDS NP_267749.1 15673575 1115253 complement(1637285..1638760) 1 NC_002662.1 evidence experimental PMID:9172368; two-component systems; sensor protein kinase 1638760 kinA 1115253 kinA Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267749.1 1637285 R 272623 CDS NP_267750.1 15673576 1115254 complement(1638768..1639460) 1 NC_002662.1 evidence experimental PMID:10708382; two-component systems; involved in arginine metabolism regulation; essential for acid stress resistance development.; two-component system regulator 1639460 llrA 1115254 llrA Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267750.1 1638768 R 272623 CDS NP_267751.1 15673577 1115255 complement(1639616..1640146) 1 NC_002662.1 hypothetical protein 1640146 yqdA 1115255 yqdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267751.1 1639616 R 272623 CDS NP_267752.1 15673578 1115256 complement(1640277..1640522) 1 NC_002662.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1640522 rpmE2 1115256 rpmE2 Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L31 NP_267752.1 1640277 R 272623 CDS NP_267753.1 15673579 1115257 complement(1640678..1641109) 1 NC_002662.1 hypothetical protein 1641109 yqeA 1115257 yqeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267753.1 1640678 R 272623 CDS NP_267754.1 15673580 1115258 complement(1641224..1641586) 1 NC_002662.1 hypothetical protein 1641586 yqeB 1115258 yqeB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267754.1 1641224 R 272623 CDS NP_267755.1 15673581 1115259 complement(1642071..1642592) 1 NC_002662.1 hypothetical protein 1642592 yqeC 1115259 yqeC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267755.1 1642071 R 272623 CDS NP_267756.1 15673582 1115260 complement(1642662..1643498) 1 NC_002662.1 probably a phosphohydrolase, evidenced by COGnitor; hypothetical protein 1643498 yqeD 1115260 yqeD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267756.1 1642662 R 272623 CDS NP_267757.1 15673583 1115261 complement(1644117..1645190) 1 NC_002662.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1645190 carA 1115261 carA Lactococcus lactis subsp. lactis Il1403 carbamoyl phosphate synthase small subunit NP_267757.1 1644117 R 272623 CDS NP_267758.1 15673584 1115262 complement(1645253..1646185) 1 NC_002662.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1646185 pyrB 1115262 pyrB Lactococcus lactis subsp. lactis Il1403 aspartate carbamoyltransferase catalytic subunit NP_267758.1 1645253 R 272623 CDS NP_267759.1 15673585 1115263 complement(1646369..1647661) 1 NC_002662.1 transport and binding protein; nucleosides, purines and pyrimidines; uracil permease 1647661 pyrP 1115263 pyrP Lactococcus lactis subsp. lactis Il1403 uracil permease NP_267759.1 1646369 R 272623 CDS NP_267760.1 15673586 1115264 complement(1647756..1648277) 1 NC_002662.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1648277 pyrR 1115264 pyrR Lactococcus lactis subsp. lactis Il1403 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase NP_267760.1 1647756 R 272623 CDS NP_267761.1 15673587 1115265 complement(1648538..1649236) 1 NC_002662.1 hypothetical protein 1649236 yqeH 1115265 yqeH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267761.1 1648538 R 272623 CDS NP_267762.1 15673588 1115266 1649332..1649631 1 NC_002662.1 ArsR family; transcriptional regulator 1649631 rarA 1115266 rarA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267762.1 1649332 D 272623 CDS NP_267763.1 15673589 1115267 1649621..1650535 1 NC_002662.1 transort and binding protein, cations; cation transport protein 1650535 yqeI 1115267 yqeI Lactococcus lactis subsp. lactis Il1403 cation transport protein NP_267763.1 1649621 D 272623 CDS NP_267764.1 15673590 1115268 complement(1650618..1651859) 1 NC_002662.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1651859 proA 1115268 proA Lactococcus lactis subsp. lactis Il1403 gamma-glutamyl phosphate reductase NP_267764.1 1650618 R 272623 CDS NP_267765.1 15673591 1115269 complement(1651877..1652689) 1 NC_002662.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1652689 proB 1115269 proB Lactococcus lactis subsp. lactis Il1403 gamma-glutamyl kinase NP_267765.1 1651877 R 272623 CDS NP_267766.1 15673592 1115270 complement(1652819..1654291) 1 NC_002662.1 hypothetical protein 1654291 yqfA 1115270 yqfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267766.1 1652819 R 272623 CDS NP_267767.1 15673593 1115271 complement(1654291..1654530) 1 NC_002662.1 hypothetical protein 1654530 yqfB 1115271 yqfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267767.1 1654291 R 272623 CDS NP_267768.1 15673594 1115272 complement(1654657..1654983) 1 NC_002662.1 hypothetical protein 1654983 yqfC 1115272 yqfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267768.1 1654657 R 272623 CDS NP_267769.1 15673595 1115273 complement(1654970..1655677) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid permease 1655677 yqfD 1115273 yqfD Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_267769.1 1654970 R 272623 CDS NP_267770.1 15673596 1115274 1655850..1656425 1 NC_002662.1 hypothetical protein 1656425 yqfE 1115274 yqfE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267770.1 1655850 D 272623 CDS NP_267771.1 15673597 1115275 1656507..1657049 1 NC_002662.1 polyamine biosynthesis; regulates polyamine concentraion by their degradation; spermidine acetyltransferase 1657049 yqfF 1115275 yqfF Lactococcus lactis subsp. lactis Il1403 spermidine acetyltransferase NP_267771.1 1656507 D 272623 CDS NP_267772.1 15673598 1115276 complement(1657076..1658632) 1 NC_002662.1 protein and peptide secretion; SRP family of GTP-binding proteins; signal recognition particle protein 1658632 ffh 1115276 ffh Lactococcus lactis subsp. lactis Il1403 signal recognition particle protein NP_267772.1 1657076 R 272623 CDS NP_267773.1 15673599 1115277 complement(1658711..1661929) 1 NC_002662.1 probably induced by the competence induction factor; hypothetical protein 1661929 yqfG 1115277 yqfG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267773.1 1658711 R 272623 CDS NP_267774.1 15673600 1115278 complement(1661978..1663690) 1 NC_002662.1 hypothetical protein 1663690 yqgA 1115278 yqgA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267774.1 1661978 R 272623 CDS NP_267775.1 15673601 1115279 1664040..1664711 1 NC_002662.1 transort and binding protein, cations; cation transport ATPase 1664711 yqgG 1115279 yqgG Lactococcus lactis subsp. lactis Il1403 cation transport ATPase NP_267775.1 1664040 D 272623 CDS NP_267776.1 15673602 1115280 complement(1664751..1665644) 1 NC_002662.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1665644 dapA 1115280 dapA Lactococcus lactis subsp. lactis Il1403 dihydrodipicolinate synthase NP_267776.1 1664751 R 272623 CDS NP_267777.1 15673603 1115281 complement(1665985..1666440) 1 NC_002662.1 Probably ADP-ribose pyrophosphatase or mutT, evidenced by COGnitor; hypothetical protein 1666440 yqgC 1115281 yqgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267777.1 1665985 R 272623 CDS NP_267778.1 15673604 1115282 complement(1666451..1667527) 1 NC_002662.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1667527 asd 1115282 asd Lactococcus lactis subsp. lactis Il1403 aspartate-semialdehyde dehydrogenase NP_267778.1 1666451 R 272623 CDS NP_267779.1 15673605 1115283 complement(1667622..1668485) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; similar to glycerol uptake facilitator GlpF of Bacillus subtilis; belongs to the transmembrane channel Mip family; transporter 1668485 yqgE 1115283 yqgE Lactococcus lactis subsp. lactis Il1403 transporter NP_267779.1 1667622 R 272623 CDS NP_267780.1 15673606 1115284 complement(1668857..1669111) 1 NC_002662.1 hypothetical protein 1669111 yqgF 1115284 yqgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267780.1 1668857 R 272623 CDS NP_267781.1 15673607 1115285 complement(1669206..1671182) 1 NC_002662.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1671182 tkt 1115285 tkt Lactococcus lactis subsp. lactis Il1403 transketolase NP_267781.1 1669206 R 272623 CDS NP_267782.1 15673608 1115286 complement(1671413..1672054) 1 NC_002662.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1672054 kdgA 1115286 kdgA Lactococcus lactis subsp. lactis Il1403 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_267782.1 1671413 R 272623 CDS NP_267783.1 15673609 1115287 complement(1672057..1673007) 1 NC_002662.1 Entner-Doudoroff pathway; glucuronate utilization pathway; 2-dehydro-3-deoxygluconokinase 1673007 kdgK 1115287 kdgK Lactococcus lactis subsp. lactis Il1403 2-dehydro-3-deoxygluconokinase NP_267783.1 1672057 R 272623 CDS NP_267784.1 15673610 1115288 complement(1673004..1674422) 1 NC_002662.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 1674422 uxaC 1115288 uxaC Lactococcus lactis subsp. lactis Il1403 glucuronate isomerase NP_267784.1 1673004 R 272623 CDS NP_267785.1 15673611 1115289 complement(1674419..1675312) 1 NC_002662.1 hypothetical protein 1675312 yqhA 1115289 yqhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267785.1 1674419 R 272623 CDS NP_267786.1 15673612 1115290 complement(1675372..1676898) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; transporter in glucuronate utilization pathway; Na-galactoside symporter 1676898 uxuT 1115290 uxuT Lactococcus lactis subsp. lactis Il1403 Na-galactoside symporter NP_267786.1 1675372 R 272623 CDS NP_267787.1 15673613 1115291 complement(1677084..1678160) 1 NC_002662.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 1678160 uxuA 1115291 uxuA Lactococcus lactis subsp. lactis Il1403 mannonate dehydratase NP_267787.1 1677084 R 272623 CDS NP_267788.1 15673614 1115292 complement(1678399..1680033) 1 NC_002662.1 sugars; glucuronate utilization pathway; fructuronate reductase 1680033 uxuB 1115292 uxuB Lactococcus lactis subsp. lactis Il1403 fructuronate reductase NP_267788.1 1678399 R 272623 CDS NP_267789.1 15673615 1115293 1680202..1680885 1 NC_002662.1 probably regulates uronic acid metabolism; GntR family transcriptional regulator 1680885 kdgR 1115293 kdgR Lactococcus lactis subsp. lactis Il1403 GntR family transcriptional regulator NP_267789.1 1680202 D 272623 CDS NP_267790.1 15673616 1115294 complement(1680931..1682361) 1 NC_002662.1 transport and binding protein; multidrug resistance; belongs to the major facilitator family, also know as drug resistance translocase family; multidrug transporter 1682361 yqiA 1115294 yqiA Lactococcus lactis subsp. lactis Il1403 multidrug transporter NP_267790.1 1680931 R 272623 CDS NP_267791.1 15673617 1115295 complement(1682562..1683536) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; ribose ABC transporter substrate binding protein 1683536 rbsB 1115295 rbsB Lactococcus lactis subsp. lactis Il1403 ribose ABC transporter substrate binding protein NP_267791.1 1682562 R 272623 CDS NP_267792.1 15673618 1115296 complement(1683548..1684489) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; ribose ABC transporter permease 1684489 rbsC 1115296 rbsC Lactococcus lactis subsp. lactis Il1403 ribose ABC transporter permease NP_267792.1 1683548 R 272623 CDS NP_267793.1 15673619 1115297 complement(1684492..1685970) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; ribose ABC transporter ATP binding protein 1685970 rbsA 1115297 rbsA Lactococcus lactis subsp. lactis Il1403 ribose ABC transporter ATP binding protein NP_267793.1 1684492 R 272623 CDS NP_267794.1 15673620 1115298 complement(1685989..1686387) 1 NC_002662.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 1686387 rbsD 1115298 rbsD Lactococcus lactis subsp. lactis Il1403 D-ribose pyranase NP_267794.1 1685989 R 272623 CDS NP_267795.1 15673621 1115299 complement(1686409..1687311) 1 NC_002662.1 energy metabolism, sugars; ribokinase 1687311 rbsK 1115299 rbsK Lactococcus lactis subsp. lactis Il1403 ribokinase NP_267795.1 1686409 R 272623 CDS NP_267796.1 15673622 1115300 complement(1687322..1688305) 1 NC_002662.1 LacI-family regulators; ribose operon repressor 1688305 rbsR 1115300 rbsR Lactococcus lactis subsp. lactis Il1403 ribose operon repressor NP_267796.1 1687322 R 272623 CDS NP_267797.1 15673623 1115301 complement(1688439..1689734) 1 NC_002662.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1689734 purB 1115301 purB Lactococcus lactis subsp. lactis Il1403 adenylosuccinate lyase NP_267797.1 1688439 R 272623 CDS NP_267798.1 15673624 1115302 complement(1689931..1690611) 1 NC_002662.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1690611 aroD 1115302 aroD Lactococcus lactis subsp. lactis Il1403 3-dehydroquinate dehydratase NP_267798.1 1689931 R 272623 CDS NP_267799.1 15673625 1115303 complement(1690874..1691077) 1 NC_002662.1 hypothetical protein 1691077 yqjA 1115303 yqjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267799.1 1690874 R 272623 CDS NP_267800.1 15673626 1115304 complement(1691321..1691635) 1 NC_002662.1 thioredoxin 1691635 trxA 1115304 trxA Lactococcus lactis subsp. lactis Il1403 thioredoxin NP_267800.1 1691321 R 272623 CDS NP_267801.1 15673627 1115305 complement(1691732..1694062) 1 NC_002662.1 DNA mismatch repair protein; hypothetical protein 1694062 mutS 1115305 mutS Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267801.1 1691732 R 272623 CDS NP_267802.1 15673628 1115306 complement(1694107..1694667) 1 NC_002662.1 similar to YshB of Bacillus subtilis; hypothetical protein 1694667 yqjB 1115306 yqjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267802.1 1694107 R 272623 CDS NP_267803.1 15673629 1115307 complement(1694827..1695792) 1 NC_002662.1 thioredoxin, glutaredoxin, and glutathione; cofactor FAD flavoprotein; pyridine nucleotide-disulfide oxidoreductase class-II; thioredoxin reductase 1695792 trxB2 1115307 trxB2 Lactococcus lactis subsp. lactis Il1403 thioredoxin reductase NP_267803.1 1694827 R 272623 CDS NP_267804.1 15673630 1115308 complement(1695930..1696928) 1 NC_002662.1 evidence experimental PMID:9922238; LacI-family regulators; catabolite control protein A 1696928 ccpA 1115308 ccpA Lactococcus lactis subsp. lactis Il1403 catabolite control protein A NP_267804.1 1695930 R 272623 CDS NP_267805.1 15673631 1115309 1697143..1698231 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; proline dipeptidase 1698231 pepQ 1115309 pepQ Lactococcus lactis subsp. lactis Il1403 proline dipeptidase NP_267805.1 1697143 D 272623 CDS NP_267806.1 15673632 1115310 complement(1698360..1700366) 1 NC_002662.1 hypothetical protein 1700366 yqjD 1115310 yqjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267806.1 1698360 R 272623 CDS NP_267807.1 15673633 1115311 complement(1700514..1701668) 1 NC_002662.1 hypothetical protein 1701668 yqjE 1115311 yqjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267807.1 1700514 R 272623 CDS NP_267808.1 15673634 1115312 complement(1701739..1701903) 1 NC_002662.1 hypothetical protein 1701903 yraA 1115312 yraA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267808.1 1701739 R 272623 CDS NP_267809.1 15673635 1115313 complement(1702302..1702688) 1 NC_002662.1 hypothetical protein 1702688 yraB 1115313 yraB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267809.1 1702302 R 272623 CDS NP_267810.1 15673636 1115314 complement(1702742..1703746) 1 NC_002662.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1703746 holA 1115314 holA Lactococcus lactis subsp. lactis Il1403 DNA polymerase III subunit delta NP_267810.1 1702742 R 272623 CDS NP_267811.1 15673637 1115315 complement(1703753..1704241) 1 NC_002662.1 hypothetical protein 1704241 yraD 1115315 yraD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267811.1 1703753 R 272623 CDS NP_267812.1 15673638 1115316 complement(1704238..1706529) 1 NC_002662.1 cell division protein; required for chromosome segregation and septum formation; may be involved in peptidoglycan synthesis or modification; hypothetical protein 1706529 ftsK 1115316 ftsK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267812.1 1704238 R 272623 CDS NP_267813.1 15673639 1115317 1706745..1707476 1 NC_002662.1 hypothetical protein 1707476 yraE 1115317 yraE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267813.1 1706745 D 272623 CDS NP_267814.1 15673640 1115318 complement(1707521..1707913) 1 NC_002662.1 hypothetical protein 1707913 yraF 1115318 yraF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267814.1 1707521 R 272623 CDS NP_267815.1 15673641 1115319 complement(1708048..1709028) 1 NC_002662.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1709028 eutD 1115319 eutD Lactococcus lactis subsp. lactis Il1403 phosphotransacetylase NP_267815.1 1708048 R 272623 CDS NP_267816.1 15673642 1115320 complement(1709245..1709865) 1 NC_002662.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1709865 udk 1115320 udk Lactococcus lactis subsp. lactis Il1403 uridine kinase NP_267816.1 1709245 R 272623 CDS NP_267817.1 15673643 1115321 1710163..1711143 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1711143 yrbA 1115321 yrbA Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267817.1 1710163 D 272623 CDS NP_267818.1 15673644 1115322 complement(1711410..1712009) 1 NC_002662.1 hypothetical protein 1712009 yrbB 1115322 yrbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267818.1 1711410 R 272623 CDS NP_267819.1 15673645 1115323 1712667..1713626 1 NC_002662.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1713626 yrbC 1115323 yrbC Lactococcus lactis subsp. lactis Il1403 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_267819.1 1712667 D 272623 CDS NP_267820.1 15673646 1115324 complement(1713651..1715189) 1 NC_002662.1 hypothetical protein 1715189 yrbD 1115324 yrbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267820.1 1713651 R 272623 CDS NP_267821.1 15673647 1115325 complement(1715358..1715591) 1 NC_002662.1 hypothetical protein 1715591 yrbE 1115325 yrbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267821.1 1715358 R 272623 CDS NP_267822.1 15673648 1115326 complement(1715613..1715882) 1 NC_002662.1 hypothetical protein 1715882 yrbF 1115326 yrbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267822.1 1715613 R 272623 CDS NP_267823.1 15673649 1115327 complement(1715912..1716553) 1 NC_002662.1 hypothetical protein 1716553 yrbG 1115327 yrbG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267823.1 1715912 R 272623 CDS NP_267824.1 15673650 1115328 complement(1716550..1716855) 1 NC_002662.1 hypothetical protein 1716855 yrbH 1115328 yrbH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267824.1 1716550 R 272623 CDS NP_267825.1 15673651 1115329 complement(1717007..1717840) 1 NC_002662.1 similar to positive regulator GadR of Lactococcus lactis; transcriptional regulator 1717840 yrbI 1115329 yrbI Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267825.1 1717007 R 272623 CDS NP_267826.1 15673652 1115331 complement(1718713..1721418) 1 NC_002662.1 evidence experimental PMID:8366036; transmembrane protein; phage infection protein 1721418 pip 1115331 pip Lactococcus lactis subsp. lactis Il1403 phage infection protein NP_267826.1 1718713 R 272623 CDS NP_267827.1 15673653 1115332 complement(1721677..1723110) 1 NC_002662.1 required for arbutin uptake and metabolism; 6-phospho-beta-glucosidase 1723110 arb 1115332 arb Lactococcus lactis subsp. lactis Il1403 6-phospho-beta-glucosidase NP_267827.1 1721677 R 272623 CDS NP_267828.1 15673654 1115333 complement(1723233..1723499) 1 NC_002662.1 similar to YtjA of Bacillus subtilis; hypothetical protein 1723499 yrcB 1115333 yrcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267828.1 1723233 R 272623 CDS NP_267829.1 15673655 1115334 complement(1723616..1725358) 1 NC_002662.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1725358 dxsB 1115334 dxsB Lactococcus lactis subsp. lactis Il1403 1-deoxy-D-xylulose-5-phosphate synthase NP_267829.1 1723616 R 272623 CDS NP_267830.1 15673656 1115335 complement(1725506..1726876) 1 NC_002662.1 two-component systems; sensor protein kinase 1726876 kinF 1115335 kinF Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267830.1 1725506 R 272623 CDS NP_267831.1 15673657 1115336 complement(1726969..1727646) 1 NC_002662.1 evidence experimental PMID:10708382; two-component systems; involved in oxidative stress resistance development; two-component system regulator 1727646 llrF 1115336 llrF Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267831.1 1726969 R 272623 CDS NP_267832.1 15673658 1115337 complement(1727815..1728789) 1 NC_002662.1 LacI-family regulators; transcriptional regulator 1728789 rliA 1115337 rliA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267832.1 1727815 R 272623 CDS NP_267833.1 15673659 1115338 complement(1728942..1731197) 1 NC_002662.1 central intermediary metabolism; maltose phosphorylase 1731197 mapA 1115338 mapA Lactococcus lactis subsp. lactis Il1403 maltose phosphorylase NP_267833.1 1728942 R 272623 CDS NP_267834.1 15673660 1115339 complement(1731220..1732857) 1 NC_002662.1 degradation of polysaccharides; alpha-glucosidase 1732857 agl 1115339 agl Lactococcus lactis subsp. lactis Il1403 alpha-glucosidase NP_267834.1 1731220 R 272623 CDS NP_267835.1 15673661 1115340 complement(1732900..1734474) 1 NC_002662.1 degradation of polysaccharides; alpha-amylase 1734474 amyY 1115340 amyY Lactococcus lactis subsp. lactis Il1403 alpha-amylase NP_267835.1 1732900 R 272623 CDS NP_267836.1 15673662 1115341 complement(1734464..1735075) 1 NC_002662.1 energy metabolism, sugars; maltose O-acetyltransferase 1735075 maa 1115341 maa Lactococcus lactis subsp. lactis Il1403 maltose O-acetyltransferase NP_267836.1 1734464 R 272623 CDS NP_267837.1 15673663 1115342 complement(1735096..1736721) 1 NC_002662.1 degradation of polysaccharides; oligo-1,6-glucosidase 1736721 dexA 1115342 dexA Lactococcus lactis subsp. lactis Il1403 oligo-1,6-glucosidase NP_267837.1 1735096 R 272623 CDS NP_267838.1 15673664 1115343 complement(1736928..1738682) 1 NC_002662.1 degradation of polysaccharides; neopullulanase 1738682 dexC 1115343 dexC Lactococcus lactis subsp. lactis Il1403 neopullulanase NP_267838.1 1736928 R 272623 CDS NP_267839.1 15673665 1115344 1739050..1740282 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; maltose ABC transporter substrate binding protein 1740282 malE 1115344 malE Lactococcus lactis subsp. lactis Il1403 maltose ABC transporter substrate binding protein NP_267839.1 1739050 D 272623 CDS NP_267840.1 15673666 1115345 1740354..1741712 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; maltose ABC transporter permease 1741712 malF 1115345 malF Lactococcus lactis subsp. lactis Il1403 maltose ABC transporter permease NP_267840.1 1740354 D 272623 CDS NP_267841.1 15673667 1115346 1741716..1742573 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; maltose ABC transporter permease 1742573 malG 1115346 malG Lactococcus lactis subsp. lactis Il1403 maltose ABC transporter permease NP_267841.1 1741716 D 272623 CDS NP_267842.1 15673668 1115347 1742733..1743728 1 NC_002662.1 hypothetical protein 1743728 yreA 1115347 yreA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267842.1 1742733 D 272623 CDS NP_267843.1 15673669 1115348 1743734..1744678 1 NC_002662.1 hypothetical protein 1744678 yreB 1115348 yreB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267843.1 1743734 D 272623 CDS NP_267844.1 15673670 1115349 1744680..1745237 1 NC_002662.1 hypothetical protein 1745237 yreC 1115349 yreC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267844.1 1744680 D 272623 CDS NP_267845.1 15673671 1115350 complement(1745270..1745806) 1 NC_002662.1 hypothetical protein 1745806 yreD 1115350 yreD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267845.1 1745270 R 272623 CDS NP_835325.1 30024051 1115351 complement(1745916..1746191) 1 NC_002662.1 hypothetical protein 1746191 1115351 L200065 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835325.1 1745916 R 272623 CDS NP_267846.1 15673672 1115352 1746412..1747098 1 NC_002662.1 hypothetical protein 1747098 yreE 1115352 yreE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267846.1 1746412 D 272623 CDS NP_267847.1 15673673 1115353 complement(1747150..1747989) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981I 1747989 tra981I 1115353 tra981I Lactococcus lactis subsp. lactis Il1403 transposase of IS981I NP_267847.1 1747150 R 272623 CDS NP_267848.1 15673674 1115354 complement(1748001..1748261) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 1748261 yrdA 1115354 yrdA Lactococcus lactis subsp. lactis Il1403 transposase NP_267848.1 1748001 R 272623 CDS NP_267849.1 15673675 1115355 1748664..1749278 1 NC_002662.1 hypothetical protein 1749278 yrdB 1115355 yrdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267849.1 1748664 D 272623 CDS NP_835326.1 30024052 1115356 1749401..1750033 1 NC_002662.1 similar to internalin; hypothetical protein 1750033 yreF 1115356 yreF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835326.1 1749401 D 272623 CDS NP_267850.1 15673676 1115357 1750127..1750429 1 NC_002662.1 ArsR family of transcription regulators; transcriptional regulator 1750429 yrfA 1115357 yrfA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267850.1 1750127 D 272623 CDS NP_267851.1 15673677 1115358 1750521..1751696 1 NC_002662.1 aerobic energy metabolism; NADH-dependent oxidoreductase 1751696 yrfB 1115358 yrfB Lactococcus lactis subsp. lactis Il1403 NADH-dependent oxidoreductase NP_267851.1 1750521 D 272623 CDS NP_267852.1 15673678 1115359 complement(1752008..1752955) 1 NC_002662.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1752955 arcC3 1115359 arcC3 Lactococcus lactis subsp. lactis Il1403 carbamate kinase NP_267852.1 1752008 R 272623 CDS NP_267853.1 15673679 1115360 complement(1752980..1754080) 1 NC_002662.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 1754080 yrfC 1115360 yrfC Lactococcus lactis subsp. lactis Il1403 agmatine deiminase NP_267853.1 1752980 R 272623 CDS NP_267854.1 15673680 1115361 1754225..1755172 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983G 1755172 tra983G 1115361 tra983G Lactococcus lactis subsp. lactis Il1403 transposase of IS983G NP_267854.1 1754225 D 272623 CDS NP_267855.1 15673681 1115362 complement(1755132..1756532) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid antiporter 1756532 yrfD 1115362 yrfD Lactococcus lactis subsp. lactis Il1403 amino acid antiporter NP_267855.1 1755132 R 272623 CDS NP_267856.1 15673682 1115363 complement(1756548..1757570) 1 NC_002662.1 catalyzes the formation of putrescine from carbamoyl-putrescine during agmatine degradation; putrescine carbamoyltransferase 1757570 otcA 1115363 otcA Lactococcus lactis subsp. lactis Il1403 putrescine carbamoyltransferase NP_267856.1 1756548 R 272623 CDS NP_267857.1 15673683 1115364 complement(1757804..1758790) 1 NC_002662.1 two-component systems; two-component system regulator 1758790 llrH 1115364 llrH Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267857.1 1757804 R 272623 CDS NP_267858.1 15673684 1115365 complement(1758958..1760361) 1 NC_002662.1 LytR family; probably a signal transducer for the regulator LrrH; transcriptional regulator 1760361 yrfE 1115365 yrfE Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267858.1 1758958 R 272623 CDS NP_267859.1 15673685 1115366 complement(1760439..1761101) 1 NC_002662.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1761101 cmk 1115366 cmk Lactococcus lactis subsp. lactis Il1403 cytidylate kinase NP_267859.1 1760439 R 272623 CDS NP_267860.1 15673686 1115367 complement(1761183..1761701) 1 NC_002662.1 hypothetical protein 1761701 yrgA 1115367 yrgA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267860.1 1761183 R 272623 CDS NP_267861.1 15673687 1115368 1761748..1761951 1 NC_002662.1 energy metabolism; electron transport; iron sulfur protein that transfers electrons in a variety of metabolic reactions; ferredoxin 1761951 fer 1115368 fer Lactococcus lactis subsp. lactis Il1403 ferredoxin NP_267861.1 1761748 D 272623 CDS NP_267862.1 15673688 1115369 1762221..1763210 1 NC_002662.1 transport and binding protein; PTS system; PTS system mannose-specific transporter subunit IIAB 1763210 ptnAB 1115369 ptnAB Lactococcus lactis subsp. lactis Il1403 PTS system mannose-specific transporter subunit IIAB NP_267862.1 1762221 D 272623 CDS NP_267863.1 15673689 1115370 1763289..1764101 1 NC_002662.1 transport and binding protein; PTS system; PTS system mannose-specific transporter subunit IIC 1764101 ptnC 1115370 ptnC Lactococcus lactis subsp. lactis Il1403 PTS system mannose-specific transporter subunit IIC NP_267863.1 1763289 D 272623 CDS NP_267864.1 15673690 1115371 1764120..1765043 1 NC_002662.1 transport and binding protein; PTS system; PTS system mannose-specific transporter subunit IID 1765043 ptnD 1115371 ptnD Lactococcus lactis subsp. lactis Il1403 PTS system mannose-specific transporter subunit IID NP_267864.1 1764120 D 272623 CDS NP_267865.1 15673691 1115372 1765185..1765568 1 NC_002662.1 hypothetical protein 1765568 yrgE 1115372 yrgE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267865.1 1765185 D 272623 CDS NP_267866.1 15673692 1115373 complement(1765593..1766288) 1 NC_002662.1 hypothetical protein 1766288 yrgF 1115373 yrgF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267866.1 1765593 R 272623 CDS NP_267867.1 15673693 1115374 1766438..1766809 1 NC_002662.1 hypothetical protein 1766809 yrgG 1115374 yrgG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267867.1 1766438 D 272623 CDS NP_267868.1 15673694 1115375 1767193..1768464 1 NC_002662.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1768464 serS 1115375 serS Lactococcus lactis subsp. lactis Il1403 seryl-tRNA synthetase NP_267868.1 1767193 D 272623 CDS NP_267869.1 15673695 1115376 1768653..1769627 1 NC_002662.1 hypothetical protein 1769627 yrgH 1115376 yrgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267869.1 1768653 D 272623 CDS NP_267870.1 15673696 1115377 1769649..1770218 1 NC_002662.1 hypothetical protein 1770218 yrgI 1115377 yrgI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267870.1 1769649 D 272623 CDS NP_267871.1 15673697 1115378 complement(1770313..1770966) 1 NC_002662.1 general regulatory function; phosphate transport system regulator 1770966 phoU 1115378 phoU Lactococcus lactis subsp. lactis Il1403 phosphate transport system regulator NP_267871.1 1770313 R 272623 CDS NP_267872.1 15673698 1115379 complement(1771129..1771890) 1 NC_002662.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1771890 pstA 1115379 pstA Lactococcus lactis subsp. lactis Il1403 phosphate transporter ATP-binding protein NP_267872.1 1771129 R 272623 CDS NP_267873.1 15673699 1115380 complement(1772056..1772865) 1 NC_002662.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1772865 pstB 1115380 pstB Lactococcus lactis subsp. lactis Il1403 phosphate transporter ATP-binding protein NP_267873.1 1772056 R 272623 CDS NP_267874.1 15673700 1115381 complement(1772899..1773792) 1 NC_002662.1 transport and binding protein, anions; phosphate ABC transporter permease 1773792 pstC 1115381 pstC Lactococcus lactis subsp. lactis Il1403 phosphate ABC transporter permease NP_267874.1 1772899 R 272623 CDS NP_267875.1 15673701 1115382 complement(1773792..1774715) 1 NC_002662.1 transport and binding protein, anions; phosphate ABC transporter permease 1774715 pstD 1115382 pstD Lactococcus lactis subsp. lactis Il1403 phosphate ABC transporter permease NP_267875.1 1773792 R 272623 CDS NP_267876.1 15673702 1115383 complement(1774836..1775687) 1 NC_002662.1 transport and binding protein, anions; identical to lipoprotein Nlp1 of Lactococcus lactis; phosphate ABC transporter substrate-binding protein 1775687 pstE 1115383 pstE Lactococcus lactis subsp. lactis Il1403 phosphate ABC transporter substrate-binding protein NP_267876.1 1774836 R 272623 CDS NP_267877.1 15673703 1115384 complement(1776034..1776930) 1 NC_002662.1 transport and binding protein, anions; similar to lipoprotein Nlp1 from Lactococcus lactis; phosphate ABC transporter substrate-binding protein 1776930 pstF 1115384 pstF Lactococcus lactis subsp. lactis Il1403 phosphate ABC transporter substrate-binding protein NP_267877.1 1776034 R 272623 CDS NP_267878.1 15673704 1115385 complement(1777208..1777675) 1 NC_002662.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1777675 smpB 1115385 smpB Lactococcus lactis subsp. lactis Il1403 SsrA-binding protein NP_267878.1 1777208 R 272623 CDS NP_267879.1 15673705 1115386 complement(1777707..1778282) 1 NC_002662.1 hypothetical protein 1778282 yrhH 1115386 yrhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267879.1 1777707 R 272623 CDS NP_267880.1 15673706 1115387 complement(1778369..1780987) 1 NC_002662.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1780987 alaS 1115387 alaS Lactococcus lactis subsp. lactis Il1403 alanyl-tRNA synthetase NP_267880.1 1778369 R 272623 CDS NP_267881.1 15673707 1115388 complement(1781253..1782179) 1 NC_002662.1 maturation protein 1782179 pmpA 1115388 pmpA Lactococcus lactis subsp. lactis Il1403 maturation protein NP_267881.1 1781253 R 272623 CDS NP_267882.1 15673708 1115389 complement(1782333..1783016) 1 NC_002662.1 SAM-dependent methyltransferase, evidenced by COGnitor; hypothetical protein 1783016 yriA 1115389 yriA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267882.1 1782333 R 272623 CDS NP_267883.1 15673709 1115390 complement(1783019..1784824) 1 NC_002662.1 evidence experimental PMID:7798200; degradation of proteins, peptides, and glycopeptides; hydrolyzes peptides containing between 7 and 17 amino acids with a rather wide specificity; peptidase family M3 (zinc metalloprotease); oligoendopeptidase F 1784824 pepF 1115390 pepF Lactococcus lactis subsp. lactis Il1403 oligoendopeptidase F NP_267883.1 1783019 R 272623 CDS NP_267884.1 15673710 1115391 complement(1784887..1785876) 1 NC_002662.1 competence protein; transformation; similar to CoiA protein in Streptococcus pneumoniae needed for competence development; CoiA 1785876 coiA 1115391 coiA Lactococcus lactis subsp. lactis Il1403 CoiA NP_267884.1 1784887 R 272623 CDS NP_267885.1 15673711 1115392 complement(1785950..1787035) 1 NC_002662.1 hypothetical protein 1787035 yriB 1115392 yriB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267885.1 1785950 R 272623 CDS NP_267886.1 15673712 1115393 complement(1787197..1788045) 1 NC_002662.1 hypothetical protein 1788045 yriC 1115393 yriC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267886.1 1787197 R 272623 CDS NP_267887.1 15673713 1115394 complement(1788237..1789658) 1 NC_002662.1 xanthine/uracil/vitamin C permease 1789658 yriD 1115394 yriD Lactococcus lactis subsp. lactis Il1403 xanthine/uracil/vitamin C permease NP_267887.1 1788237 R 272623 CDS NP_267888.1 15673714 1115395 1789965..1790801 1 NC_002662.1 hypothetical protein 1790801 yrjA 1115395 yrjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267888.1 1789965 D 272623 CDS NP_267889.1 15673715 1115396 1790982..1791752 1 NC_002662.1 aerobic energy metabolism; similar to different oxido-reductases; oxidoreductase 1791752 yrjB 1115396 yrjB Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267889.1 1790982 D 272623 CDS NP_267890.1 15673716 1115397 1791762..1793234 1 NC_002662.1 aerobic energy metabolism; similar to several iron-binding oxidase subunit proteins; iron-binding oxidase subunit 1793234 yrjC 1115397 yrjC Lactococcus lactis subsp. lactis Il1403 iron-binding oxidase subunit NP_267890.1 1791762 D 272623 CDS NP_267891.1 15673717 1115398 1793237..1793920 1 NC_002662.1 hypothetical protein 1793920 yrjD 1115398 yrjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267891.1 1793237 D 272623 CDS NP_267892.1 15673718 1115399 complement(1793995..1794708) 1 NC_002662.1 transport and binding protein; similar to several permeases; transport permease 1794708 yrjE 1115399 yrjE Lactococcus lactis subsp. lactis Il1403 transport permease NP_267892.1 1793995 R 272623 CDS NP_267893.1 15673719 1115400 complement(1794821..1795735) 1 NC_002662.1 hypothetical protein 1795735 yrjF 1115400 yrjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267893.1 1794821 R 272623 CDS NP_267894.1 15673720 1115401 complement(1795892..1796404) 1 NC_002662.1 hypothetical protein 1796404 yrjG 1115401 yrjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267894.1 1795892 R 272623 CDS NP_267895.1 15673721 1115402 1796737..1796970 1 NC_002662.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1796970 rpsT 1115402 rpsT Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S20 NP_267895.1 1796737 D 272623 CDS NP_267896.1 15673722 1115403 complement(1797064..1799568) 1 NC_002662.1 exodeoxyribonuclease V subunit alpha 1799568 recD 1115403 recD Lactococcus lactis subsp. lactis Il1403 exodeoxyribonuclease V subunit alpha NP_267896.1 1797064 R 272623 CDS NP_267897.1 15673723 1115404 complement(1799565..1800158) 1 NC_002662.1 glycolysis; similar to phosphoglycerate mutases or 6-phosphofructo-2-kinases; phosphoglycerate mutase 1800158 yrjI 1115404 yrjI Lactococcus lactis subsp. lactis Il1403 phosphoglycerate mutase NP_267897.1 1799565 R 272623 CDS NP_267898.1 15673724 1115405 complement(1800161..1801000) 1 NC_002662.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1801000 pheA 1115405 pheA Lactococcus lactis subsp. lactis Il1403 prephenate dehydratase NP_267898.1 1800161 R 272623 CDS NP_267899.1 15673725 1115406 complement(1801002..1801490) 1 NC_002662.1 evidence experimental PMID:7823907; aromatic amino-acid family; shikimate kinase 1801490 aroK 1115406 aroK Lactococcus lactis subsp. lactis Il1403 shikimate kinase NP_267899.1 1801002 R 272623 CDS NP_267900.1 15673726 1115407 complement(1801514..1802806) 1 NC_002662.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1802806 aroA 1115407 aroA Lactococcus lactis subsp. lactis Il1403 3-phosphoshikimate 1-carboxyvinyltransferase NP_267900.1 1801514 R 272623 CDS NP_267901.1 15673727 1115408 complement(1802927..1803991) 1 NC_002662.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1803991 tyrA 1115408 tyrA Lactococcus lactis subsp. lactis Il1403 prephenate dehydrogenase NP_267901.1 1802927 R 272623 CDS NP_267902.1 15673728 1115409 complement(1803994..1804869) 1 NC_002662.1 two-component systems; sensor protein kinase 1804869 kinG 1115409 kinG Lactococcus lactis subsp. lactis Il1403 sensor protein kinase NP_267902.1 1803994 R 272623 CDS NP_267903.1 15673729 1115410 complement(1804856..1805527) 1 NC_002662.1 two-component systems; two-component system regulator 1805527 llrG 1115410 llrG Lactococcus lactis subsp. lactis Il1403 two-component system regulator NP_267903.1 1804856 R 272623 CDS NP_267904.1 15673730 1115411 complement(1805530..1806594) 1 NC_002662.1 hypothetical protein 1806594 ysaA 1115411 ysaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267904.1 1805530 R 272623 CDS NP_267905.1 15673731 1115412 complement(1806775..1808778) 1 NC_002662.1 transport and binding protein; probably the same function as YtsD of Bacillus subtilis; ABC transporter permease and substrate binding protein 1808778 ysaB 1115412 ysaB Lactococcus lactis subsp. lactis Il1403 ABC transporter permease and substrate binding protein NP_267905.1 1806775 R 272623 CDS NP_267906.1 15673732 1115413 complement(1808771..1809550) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 1809550 ysaC 1115413 ysaC Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267906.1 1808771 R 272623 CDS NP_267907.1 15673733 1115414 complement(1809739..1810098) 1 NC_002662.1 hypothetical protein 1810098 ysaD 1115414 ysaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267907.1 1809739 R 272623 CDS NP_267908.1 15673734 1115415 complement(1810217..1811383) 1 NC_002662.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1811383 aroC 1115415 aroC Lactococcus lactis subsp. lactis Il1403 chorismate synthase NP_267908.1 1810217 R 272623 CDS NP_267909.1 15673735 1115416 complement(1811414..1812010) 1 NC_002662.1 hypothetical protein 1812010 ysbA 1115416 ysbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267909.1 1811414 R 272623 CDS NP_267910.1 15673736 1115417 complement(1812015..1812614) 1 NC_002662.1 similar to YktB of Bacillus subtilis; hypothetical protein 1812614 ysbB 1115417 ysbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267910.1 1812015 R 272623 CDS NP_267911.1 15673737 1115418 complement(1812726..1813649) 1 NC_002662.1 hypothetical protein 1813649 ysbC 1115418 ysbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267911.1 1812726 R 272623 CDS NP_267912.1 15673738 1115419 complement(1813760..1814830) 1 NC_002662.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1814830 aroB 1115419 aroB Lactococcus lactis subsp. lactis Il1403 3-dehydroquinate synthase NP_267912.1 1813760 R 272623 CDS NP_267913.1 15673739 1115420 complement(1814827..1815687) 1 NC_002662.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1815687 aroE 1115420 aroE Lactococcus lactis subsp. lactis Il1403 shikimate 5-dehydrogenase NP_267913.1 1814827 R 272623 CDS NP_267914.1 15673740 1115421 complement(1815855..1816511) 1 NC_002662.1 hypothetical protein 1816511 ysbD 1115421 ysbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267914.1 1815855 R 272623 CDS NP_267915.1 15673741 1115422 1816892..1819036 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; N-terimal 500 aa is substrate binding, and the C-terminal is permease domain; glutamine ABC transporter permease and substrate binding protein 1819036 glnP 1115422 glnP Lactococcus lactis subsp. lactis Il1403 glutamine ABC transporter permease and substrate binding protein NP_267915.1 1816892 D 272623 CDS NP_267916.1 15673742 1115423 1819052..1819795 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; glutamine ABC transporter ATP-binding protein 1819795 glnQ 1115423 glnQ Lactococcus lactis subsp. lactis Il1403 glutamine ABC transporter ATP-binding protein NP_267916.1 1819052 D 272623 CDS NP_267917.1 15673743 1115424 complement(1819904..1821823) 1 NC_002662.1 hypothetical protein 1821823 yscA 1115424 yscA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267917.1 1819904 R 272623 CDS NP_267918.1 15673744 1115425 complement(1821845..1822486) 1 NC_002662.1 hypothetical protein 1822486 yscB 1115425 yscB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267918.1 1821845 R 272623 CDS NP_267919.1 15673745 1115426 complement(1822602..1823027) 1 NC_002662.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1823027 atpC 1115426 atpC Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit epsilon NP_267919.1 1822602 R 272623 CDS NP_267920.1 15673746 1115427 complement(1823212..1824621) 1 NC_002662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1824621 atpD 1115427 atpD Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit beta NP_267920.1 1823212 R 272623 CDS NP_267921.1 15673747 1115428 complement(1824754..1825623) 1 NC_002662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1825623 atpG 1115428 atpG Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit gamma NP_267921.1 1824754 R 272623 CDS NP_267922.1 15673748 1115429 complement(1825639..1827141) 1 NC_002662.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1827141 atpA 1115429 atpA Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit alpha NP_267922.1 1825639 R 272623 CDS NP_267923.1 15673749 1115430 complement(1827328..1827855) 1 NC_002662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1827855 atpH 1115430 atpH Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit delta NP_267923.1 1827328 R 272623 CDS NP_267924.1 15673750 1115431 complement(1827857..1828363) 1 NC_002662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1828363 atpF 1115431 atpF Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit B NP_267924.1 1827857 R 272623 CDS NP_267925.2 30024053 1115432 complement(1828378..1829091) 1 NC_002662.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1829091 atpB 1115432 atpB Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit A NP_267925.2 1828378 R 272623 CDS NP_267926.1 15674249 1115433 complement(1829136..1829351) 1 NC_002662.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1829351 atpE 1115433 atpE Lactococcus lactis subsp. lactis Il1403 F0F1 ATP synthase subunit C NP_267926.1 1829136 R 272623 CDS NP_267928.1 15673753 1115435 complement(1829535..1830311) 1 NC_002662.1 fatty acid and phospholipid metabolism; lipase 1830311 yscE 1115435 yscE Lactococcus lactis subsp. lactis Il1403 lipase NP_267928.1 1829535 R 272623 CDS NP_267929.1 15673754 1115436 complement(1830596..1832806) 1 NC_002662.1 competence protein; transformation; required for internalisation of transforming DNA, but is dispensable for DNA binding.; hypothetical protein 1832806 comEC 1115436 comEC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267929.1 1830596 R 272623 CDS NP_267930.1 15673755 1115437 complement(1832787..1833434) 1 NC_002662.1 competence protein; DNA receptor during transformation; membrane protein; hypothetical protein 1833434 comEA 1115437 comEA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267930.1 1832787 R 272623 CDS NP_267931.1 15673756 1115438 complement(1833494..1834855) 1 NC_002662.1 transport and binding protein; ABC transporter permease 1834855 ysdA 1115438 ysdA Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_267931.1 1833494 R 272623 CDS NP_267932.1 15673757 1115439 complement(1834852..1835784) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 1835784 ysdB 1115439 ysdB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267932.1 1834852 R 272623 CDS NP_267933.1 15673758 1115440 complement(1835889..1836287) 1 NC_002662.1 hypothetical protein 1836287 ysdC 1115440 ysdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267933.1 1835889 R 272623 CDS NP_267934.1 15673759 1115441 complement(1836391..1836954) 1 NC_002662.1 drug and analog sensitivity; acyltransferase 1836954 bar 1115441 bar Lactococcus lactis subsp. lactis Il1403 acyltransferase NP_267934.1 1836391 R 272623 CDS NP_267935.1 15673760 1115442 complement(1837127..1838305) 1 NC_002662.1 transort and binding protein, cations; cation transporter 1838305 ysdE 1115442 ysdE Lactococcus lactis subsp. lactis Il1403 cation transporter NP_267935.1 1837127 R 272623 CDS NP_267936.1 15673761 1115443 complement(1838686..1839342) 1 NC_002662.1 transcription regulator; in Bacillus subtilis production of several extracellular degradative enzymes at the transcription level, probably by interfering with DegS and DegU, which are required from this effect; TenA protein 1839342 tenA 1115443 tenA Lactococcus lactis subsp. lactis Il1403 TenA protein NP_267936.1 1838686 R 272623 CDS NP_835327.1 30024054 1115444 complement(1839378..1839683) 1 NC_002662.1 hypothetical protein 1839683 1115444 L200067 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835327.1 1839378 R 272623 CDS NP_267937.1 15673762 1115445 complement(1839700..1840671) 1 NC_002662.1 bifunctional protein; biotin-(acetyl-CoA carboxylase) ligase; biotin operon repressor 1840671 birA1 1115445 birA1 Lactococcus lactis subsp. lactis Il1403 biotin operon repressor NP_267937.1 1839700 R 272623 CDS NP_267938.1 15673763 1115446 complement(1840677..1841246) 1 NC_002662.1 hypothetical protein 1841246 yseA 1115446 yseA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267938.1 1840677 R 272623 CDS NP_267939.1 15673764 1115447 1841391..1842632 1 NC_002662.1 hypothetical protein 1842632 yseB 1115447 yseB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267939.1 1841391 D 272623 CDS NP_267940.1 15673765 1115448 1842622..1843770 1 NC_002662.1 fatty acid and phospholipid metabolism; acetyl coenzyme A acetyltransferase 1843770 fadA 1115448 fadA Lactococcus lactis subsp. lactis Il1403 acetyl coenzyme A acetyltransferase NP_267940.1 1842622 D 272623 CDS NP_267941.1 15673766 1115449 1843755..1844117 1 NC_002662.1 hypothetical protein 1844117 yseC 1115449 yseC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267941.1 1843755 D 272623 CDS NP_267942.1 15673767 1115450 1844092..1844385 1 NC_002662.1 hypothetical protein 1844385 yseD 1115450 yseD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267942.1 1844092 D 272623 CDS NP_267943.1 15673768 1115451 1844382..1845128 1 NC_002662.1 fatty acid and phospholipid metabolism; 3-oxoacyl-ACP reductase 1845128 fabG2 1115451 fabG2 Lactococcus lactis subsp. lactis Il1403 3-oxoacyl-ACP reductase NP_267943.1 1844382 D 272623 CDS NP_267944.1 15673769 1115452 1845151..1845996 1 NC_002662.1 energy metabolism; fermentation; similar to 2-nitropropane dioxygenase; 2-nitropropane dioxygenase 1845996 yseE 1115452 yseE Lactococcus lactis subsp. lactis Il1403 2-nitropropane dioxygenase NP_267944.1 1845151 D 272623 CDS NP_267945.1 15673770 1115453 complement(1846137..1847549) 1 NC_002662.1 hypothetical protein 1847549 yseF 1115453 yseF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267945.1 1846137 R 272623 CDS NP_267946.2 30024055 1115454 complement(1847783..1848241) 1 NC_002662.1 energy metabolism; electron transport; involved in Fe-S cluster formation; hypothetical protein 1848241 nifU 1115454 nifU Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267946.2 1847783 R 272623 CDS NP_267947.1 15673772 1115455 complement(1848357..1848839) 1 NC_002662.1 hypothetical protein 1848839 yseH 1115455 yseH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267947.1 1848357 R 272623 CDS NP_267948.1 15673773 1115456 complement(1848841..1850058) 1 NC_002662.1 selenocysteine lyase, evidenced by COGnitor; similar to YurW of Bacillus subtilis; hypothetical protein 1850058 yseI 1115456 yseI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267948.1 1848841 R 272623 CDS NP_267949.1 15673774 1115457 complement(1850058..1851314) 1 NC_002662.1 hypothetical protein 1851314 ysfA 1115457 ysfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267949.1 1850058 R 272623 CDS NP_267950.1 15673775 1115458 complement(1851452..1852222) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 1852222 ysfB 1115458 ysfB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_267950.1 1851452 R 272623 CDS NP_267951.1 15673776 1115459 complement(1852397..1853728) 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to TagO of Bacillus subtilis involved in teichoic acid linkage unit synthesis; polysacharide biosynthesis protein 1853728 ysfC 1115459 ysfC Lactococcus lactis subsp. lactis Il1403 polysacharide biosynthesis protein NP_267951.1 1852397 R 272623 CDS NP_267952.1 15673777 1115460 complement(1853731..1854432) 1 NC_002662.1 similar to MecA protein from Bacillus; regulatory protein 1854432 ysfD 1115460 ysfD Lactococcus lactis subsp. lactis Il1403 regulatory protein NP_267952.1 1853731 R 272623 CDS NP_267953.1 15673778 1115461 complement(1854562..1855296) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; glutamate ABC transporter ATP-binding protein 1855296 gltQ 1115461 gltQ Lactococcus lactis subsp. lactis Il1403 glutamate ABC transporter ATP-binding protein NP_267953.1 1854562 R 272623 CDS NP_267954.1 15673779 1115462 complement(1855296..1855982) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; glutamate ABC transporter permease 1855982 gltP 1115462 gltP Lactococcus lactis subsp. lactis Il1403 glutamate ABC transporter permease NP_267954.1 1855296 R 272623 CDS NP_267955.1 15673780 1115463 complement(1856130..1857038) 1 NC_002662.1 similar to YtlR of Bacillus subtilis; transcriptional regulator 1857038 ysfG 1115463 ysfG Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267955.1 1856130 R 272623 CDS NP_267956.1 15673781 1115464 complement(1857183..1860779) 1 NC_002662.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1860779 rpoC 1115464 rpoC Lactococcus lactis subsp. lactis Il1403 DNA-directed RNA polymerase subunit beta' NP_267956.1 1857183 R 272623 CDS NP_267957.1 15673782 1115465 complement(1860915..1864505) 1 NC_002662.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1864505 rpoB 1115465 rpoB Lactococcus lactis subsp. lactis Il1403 DNA-directed RNA polymerase subunit beta NP_267957.1 1860915 R 272623 CDS NP_267958.1 15673783 1115466 complement(1864771..1865379) 1 NC_002662.1 CodY family of transcription regulators; transcriptional regulator 1865379 codZ 1115466 codZ Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267958.1 1864771 R 272623 CDS NP_267959.1 15673784 1115467 1865612..1866286 1 NC_002662.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000; transcriptional regulator 1866286 ysgA 1115467 ysgA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_267959.1 1865612 D 272623 CDS NP_267960.1 15673785 1115468 1866399..1868282 1 NC_002662.1 evidence experimental PMID:8244921; degradation of proteins, peptides, and glycopeptides; neutral endopeptidase 1868282 pepO 1115468 pepO Lactococcus lactis subsp. lactis Il1403 neutral endopeptidase NP_267960.1 1866399 D 272623 CDS NP_267961.1 15673786 1115469 complement(1868336..1868641) 1 NC_002662.1 hypothetical protein 1868641 ysgB 1115469 ysgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267961.1 1868336 R 272623 CDS NP_267962.1 15673787 1115470 complement(1868710..1870383) 1 NC_002662.1 hypothetical protein 1870383 ysgC 1115470 ysgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267962.1 1868710 R 272623 CDS NP_267963.1 15673788 1115471 1870593..1872044 1 NC_002662.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1872044 murE 1115471 murE Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_267963.1 1870593 D 272623 CDS NP_267964.1 15673789 1115472 complement(1872404..1873426) 1 NC_002662.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1873426 adhA 1115472 adhA Lactococcus lactis subsp. lactis Il1403 alcohol dehydrogenase NP_267964.1 1872404 R 272623 CDS NP_267965.1 15673790 1115473 1873622..1875400 1 NC_002662.1 ATP-dependent DNA helicase; transformation; probably a part of the competence regulon; ATP-dependent DNA helicase RecQ 1875400 recQ 1115473 recQ Lactococcus lactis subsp. lactis Il1403 ATP-dependent DNA helicase RecQ NP_267965.1 1873622 D 272623 CDS NP_267966.2 30024056 1115474 complement(1875436..1876962) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 1876962 yshA 1115474 yshA Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_267966.2 1875436 R 272623 CDS NP_267967.1 15673792 1115475 complement(1877242..1878483) 1 NC_002662.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1878483 pepT 1115475 pepT Lactococcus lactis subsp. lactis Il1403 peptidase T NP_267967.1 1877242 R 272623 CDS NP_267968.1 15673793 1115476 complement(1878512..1879309) 1 NC_002662.1 hypothetical protein 1879309 yshB 1115476 yshB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267968.1 1878512 R 272623 CDS NP_267969.1 15673794 1115477 complement(1879309..1880253) 1 NC_002662.1 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 1880253 yshC 1115477 yshC Lactococcus lactis subsp. lactis Il1403 manganese-dependent inorganic pyrophosphatase NP_267969.1 1879309 R 272623 CDS NP_267970.1 15673795 1115478 complement(1880457..1881251) 1 NC_002662.1 pyruvate-formate lyase activating enzyme 1881251 pflA 1115478 pflA Lactococcus lactis subsp. lactis Il1403 pyruvate-formate lyase activating enzyme NP_267970.1 1880457 R 272623 CDS NP_267971.1 15673796 1115479 complement(1881457..1882806) 1 NC_002662.1 transport and binding protein; transporter 1882806 ysiA 1115479 ysiA Lactococcus lactis subsp. lactis Il1403 transporter NP_267971.1 1881457 R 272623 CDS NP_267972.1 15673797 1115480 complement(1882927..1884042) 1 NC_002662.1 transport and binding protein; permease 1884042 ysiB 1115480 ysiB Lactococcus lactis subsp. lactis Il1403 permease NP_267972.1 1882927 R 272623 CDS NP_267973.1 15673798 1115481 1884191..1884634 1 NC_002662.1 probably acyltransferase, evidenced by COGnitor; hypothetical protein 1884634 ysiC 1115481 ysiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267973.1 1884191 D 272623 CDS NP_267974.1 15673799 1115482 complement(1884712..1885293) 1 NC_002662.1 similar to HI0220.2 of Haemophilus influenzae Rd; hypothetical protein 1885293 ysiD 1115482 ysiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267974.1 1884712 R 272623 CDS NP_267975.1 15673800 1115483 complement(1885624..1888446) 1 NC_002662.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1888446 uvrA 1115483 uvrA Lactococcus lactis subsp. lactis Il1403 excinuclease ABC subunit A NP_267975.1 1885624 R 272623 CDS NP_267976.1 15673801 1115484 complement(1888525..1889163) 1 NC_002662.1 hypothetical protein 1889163 ysiE 1115484 ysiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267976.1 1888525 R 272623 CDS NP_267977.1 15673802 1115485 1889232..1889756 1 NC_002662.1 riboflavin and cobalamin; similar to phosphoglycerate mutases; alpha-ribazole-5'-phosphate phosphatase 1889756 cobC 1115485 cobC Lactococcus lactis subsp. lactis Il1403 alpha-ribazole-5'-phosphate phosphatase NP_267977.1 1889232 D 272623 CDS NP_267978.1 15673803 1115486 1889753..1890067 1 NC_002662.1 similar to YazA of Bacillus subtilis; hypothetical protein 1890067 ysiG 1115486 ysiG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267978.1 1889753 D 272623 CDS NP_267979.1 15673804 1115487 complement(1890081..1891430) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases; amino acid permease 1891430 ysjA 1115487 ysjA Lactococcus lactis subsp. lactis Il1403 amino acid permease NP_267979.1 1890081 R 272623 CDS NP_267980.1 15673805 1115488 complement(1891913..1892830) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1892830 ysjB 1115488 ysjB Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_267980.1 1891913 R 272623 CDS NP_267981.1 15673806 1115489 complement(1892862..1893497) 1 NC_002662.1 similar to YloS protein of Bacillus subtilis; hypothetical protein 1893497 ysjC 1115489 ysjC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267981.1 1892862 R 272623 CDS NP_267982.1 15673807 1115490 complement(1893494..1893841) 1 NC_002662.1 hypothetical protein 1893841 ysjD 1115490 ysjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267982.1 1893494 R 272623 CDS NP_267983.1 15673808 1115491 complement(1893866..1894297) 1 NC_002662.1 hypothetical protein 1894297 ysjE 1115491 ysjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267983.1 1893866 R 272623 CDS NP_267984.1 15673809 1115492 1894511..1895050 1 NC_002662.1 hypothetical protein 1895050 ysjF 1115492 ysjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267984.1 1894511 D 272623 CDS NP_267985.1 15673810 1115493 complement(1895088..1896431) 1 NC_002662.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1896431 asnC 1115493 asnC Lactococcus lactis subsp. lactis Il1403 asparaginyl-tRNA synthetase NP_267985.1 1895088 R 272623 CDS NP_267986.1 15673811 1115494 complement(1896479..1896790) 1 NC_002662.1 hypothetical protein 1896790 ysjG 1115494 ysjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267986.1 1896479 R 272623 CDS NP_267987.1 15673812 1115495 complement(1896787..1897968) 1 NC_002662.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1897968 aspB 1115495 aspB Lactococcus lactis subsp. lactis Il1403 aspartate aminotransferase NP_267987.1 1896787 R 272623 CDS NP_267988.1 15673813 1115496 complement(1897965..1898408) 1 NC_002662.1 hypothetical protein 1898408 ysjH 1115496 ysjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267988.1 1897965 R 272623 CDS NP_267989.1 15673814 1115497 complement(1898543..1900927) 1 NC_002662.1 ATP-dependent helicase; DNA replication, restriction, modification, recombination, and repair; helicase involved in DNA repair and perhaps also replication; DinG 1900927 dinG 1115497 dinG Lactococcus lactis subsp. lactis Il1403 DinG NP_267989.1 1898543 R 272623 CDS NP_267990.1 15673815 1115498 1901147..1901584 1 NC_002662.1 hypothetical protein 1901584 ytaA 1115498 ytaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267990.1 1901147 D 272623 CDS NP_267991.1 15673816 1115499 complement(1901638..1902930) 1 NC_002662.1 transport and binding protein; similar to CBS domain-containing proteins; hypothetical protein 1902930 ytaB 1115499 ytaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_267991.1 1901638 R 272623 CDS NP_267992.1 15673817 1115500 complement(1903070..1904071) 1 NC_002662.1 drug and analog sensitivity; penicillin acylase 1904071 pacB 1115500 pacB Lactococcus lactis subsp. lactis Il1403 penicillin acylase NP_267992.1 1903070 R 272623 CDS NP_267993.1 15673818 1115501 complement(1904143..1904889) 1 NC_002662.1 translation; protein modification; tyrosine phosphatase 1904889 ytaD 1115501 ytaD Lactococcus lactis subsp. lactis Il1403 tyrosine phosphatase NP_267993.1 1904143 R 272623 CDS NP_267994.1 15673819 1115502 complement(1905092..1906894) 1 NC_002662.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter substrate binding protein 1906894 oppA 1115502 oppA Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter substrate binding protein NP_267994.1 1905092 R 272623 CDS NP_267995.1 15673820 1115503 complement(1906999..1907883) 1 NC_002662.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter permease 1907883 oppC 1115503 oppC Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter permease NP_267995.1 1906999 R 272623 CDS NP_267996.1 15673821 1115504 complement(1907893..1908852) 1 NC_002662.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter permease 1908852 oppB 1115504 oppB Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter permease NP_267996.1 1907893 R 272623 CDS NP_267997.1 15673822 1115505 complement(1908833..1909792) 1 NC_002662.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter ATP binding protein 1909792 oppF 1115505 oppF Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter ATP binding protein NP_267997.1 1908833 R 272623 CDS NP_267998.1 15673823 1115506 complement(1909789..1910805) 1 NC_002662.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines; oligopeptide ABC transporter ATP binding protein 1910805 oppD 1115506 oppD Lactococcus lactis subsp. lactis Il1403 oligopeptide ABC transporter ATP binding protein NP_267998.1 1909789 R 272623 CDS NP_267999.1 15673824 1115507 complement(1911031..1911390) 1 NC_002662.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1911390 rplT 1115507 rplT Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L20 NP_267999.1 1911031 R 272623 CDS NP_268000.1 15673825 1115508 complement(1911552..1911752) 1 NC_002662.1 ribosomal proteins; synthesis and modification; L35P family of ribosomal proteins; 50S ribosomal protein L35 1911752 rpmI 1115508 rpmI Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L35 NP_268000.1 1911552 R 272623 CDS NP_268001.1 15673826 1115509 complement(1911881..1912375) 1 NC_002662.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1912375 infC 1115509 infC Lactococcus lactis subsp. lactis Il1403 translation initiation factor IF-3 NP_268001.1 1911881 R 272623 CDS NP_268002.1 15673827 1115510 1912985..1913533 1 NC_002662.1 hypothetical protein 1913533 ytbA 1115510 ytbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268002.1 1912985 D 272623 CDS NP_268003.1 15673828 1115511 complement(1913544..1914248) 1 NC_002662.1 hypothetical protein 1914248 ytbB 1115511 ytbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268003.1 1913544 R 272623 CDS NP_268004.1 15673829 1115512 complement(1914418..1916295) 1 NC_002662.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 1916295 gidA 1115512 gidA Lactococcus lactis subsp. lactis Il1403 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_268004.1 1914418 R 272623 CDS NP_268005.1 15673830 1115513 complement(1916668..1917243) 1 NC_002662.1 hypothetical protein 1917243 ytbC 1115513 ytbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268005.1 1916668 R 272623 CDS NP_268006.1 15673831 1115514 complement(1917376..1917744) 1 NC_002662.1 hypothetical protein 1917744 ytbD 1115514 ytbD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268006.1 1917376 R 272623 CDS NP_268007.1 15673832 1115515 complement(1917860..1918261) 1 NC_002662.1 similar to YazC of Bacillus subtilis; hypothetical protein 1918261 ytbE 1115515 ytbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268007.1 1917860 R 272623 CDS NP_268008.1 15673833 1115516 complement(1918254..1919600) 1 NC_002662.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1919600 cysS 1115516 cysS Lactococcus lactis subsp. lactis Il1403 cysteinyl-tRNA synthetase NP_268008.1 1918254 R 272623 CDS NP_268009.1 15673834 1115517 complement(1919613..1920206) 1 NC_002662.1 hypothetical protein 1920206 ytcA 1115517 ytcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268009.1 1919613 R 272623 CDS NP_268010.1 15673835 1115518 complement(1920220..1920819) 1 NC_002662.1 serine family; serine acetyltransferase 1920819 cysE 1115518 cysE Lactococcus lactis subsp. lactis Il1403 serine acetyltransferase NP_268010.1 1920220 R 272623 CDS NP_268011.1 15673836 1115519 complement(1920926..1921696) 1 NC_002662.1 hypothetical protein 1921696 ytcB 1115519 ytcB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268011.1 1920926 R 272623 CDS NP_268012.1 15673837 1115520 complement(1921905..1924226) 1 NC_002662.1 degradation of RNA; polynucleotide phosphorylase/polyadenylase 1924226 pnpA 1115520 pnpA Lactococcus lactis subsp. lactis Il1403 polynucleotide phosphorylase/polyadenylase NP_268012.1 1921905 R 272623 CDS NP_268013.1 15673838 1115521 complement(1924510..1925655) 1 NC_002662.1 hypothetical protein 1925655 ytcC 1115521 ytcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268013.1 1924510 R 272623 CDS NP_268014.1 15673839 1115522 1926020..1926985 1 NC_002662.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1926985 prsB 1115522 prsB Lactococcus lactis subsp. lactis Il1403 ribose-phosphate pyrophosphokinase NP_268014.1 1926020 D 272623 CDS NP_268015.1 15673840 1115523 complement(1927107..1927538) 1 NC_002662.1 hypothetical protein 1927538 ytcD 1115523 ytcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268015.1 1927107 R 272623 CDS NP_268016.1 15673841 1115524 1927778..1928905 1 NC_002662.1 energy metabolism, electron transport; similar to YrvO of Bacillus subtilis; cysteine sulfinate desulfinase/cysteine desulfurase, evidenced by COGnitor; pyridoxal-phosphate dependent aminotransferase 1928905 nifS 1115524 nifS Lactococcus lactis subsp. lactis Il1403 pyridoxal-phosphate dependent aminotransferase NP_268016.1 1927778 D 272623 CDS NP_268017.1 15673842 1115525 1928929..1929273 1 NC_002662.1 hypothetical protein 1929273 ytcE 1115525 ytcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268017.1 1928929 D 272623 CDS NP_268018.1 15673843 1115526 complement(1929364..1930551) 1 NC_002662.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1930551 tuf 1115526 tuf Lactococcus lactis subsp. lactis Il1403 elongation factor Tu NP_268018.1 1929364 R 272623 CDS NP_268019.1 15673844 1115527 1930794..1930976 1 NC_002662.1 hypothetical protein 1930976 ytdA 1115527 ytdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268019.1 1930794 D 272623 CDS NP_268020.1 15673845 1115528 complement(1931209..1934007) 1 NC_002662.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1934007 ileS 1115528 ileS Lactococcus lactis subsp. lactis Il1403 isoleucyl-tRNA synthetase NP_268020.1 1931209 R 272623 CDS NP_268021.1 15673846 1115529 complement(1934323..1935249) 1 NC_002662.1 similar to cell division protein DivIVA of Bacillus subtilis; hypothetical protein 1935249 ytdB 1115529 ytdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268021.1 1934323 R 272623 CDS NP_268022.1 15673847 1115530 complement(1935306..1936097) 1 NC_002662.1 similar to YlmH of Bacillus subtilis; hypothetical protein 1936097 ytdC 1115530 ytdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268022.1 1935306 R 272623 CDS NP_268023.1 15673848 1115531 complement(1936094..1936369) 1 NC_002662.1 similar to YlmG of Bacillus subtilis; hypothetical protein 1936369 ytdD 1115531 ytdD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268023.1 1936094 R 272623 CDS NP_268024.1 15673849 1115532 complement(1936369..1936959) 1 NC_002662.1 similar to YlmF of Bacillus subtilis; hypothetical protein 1936959 ytdE 1115532 ytdE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268024.1 1936369 R 272623 CDS NP_268025.1 15673850 1115533 complement(1936993..1937670) 1 NC_002662.1 similar to YlmE of Bacillus subtilis; hypothetical protein 1937670 ytdF 1115533 ytdF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268025.1 1936993 R 272623 CDS NP_268026.1 15673851 1115534 complement(1937674..1938927) 1 NC_002662.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1938927 ftsZ 1115534 ftsZ Lactococcus lactis subsp. lactis Il1403 cell division protein FtsZ NP_268026.1 1937674 R 272623 CDS NP_268027.1 15673852 1115535 complement(1938958..1940328) 1 NC_002662.1 cell division protein; hypothetical protein 1940328 ftsA 1115535 ftsA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268027.1 1938958 R 272623 CDS NP_268028.1 15673853 1115536 complement(1940489..1941358) 1 NC_002662.1 similar to YitS protein from Bacillus subtilis.; hypothetical protein 1941358 yteA 1115536 yteA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268028.1 1940489 R 272623 CDS NP_268029.1 15673854 1115537 complement(1941471..1942199) 1 NC_002662.1 tRNA modification; methylates guanosine-18 in various tRNAS; tRNA-guanosine methyltransferase 1942199 trmH 1115537 trmH Lactococcus lactis subsp. lactis Il1403 tRNA-guanosine methyltransferase NP_268029.1 1941471 R 272623 CDS NP_268030.2 30024057 1115538 complement(1942345..1943463) 1 NC_002662.1 similar to oxidoreductases; hypothetical protein 1943463 yteB 1115538 yteB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268030.2 1942345 R 272623 CDS NP_268031.1 15673856 1115539 complement(1943594..1944439) 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 1944439 yteC 1115539 yteC Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_268031.1 1943594 R 272623 CDS NP_268032.1 15673857 1115540 complement(1944451..1945779) 1 NC_002662.1 transport and binding protein; transmembrane efflux protein 1945779 yteD 1115540 yteD Lactococcus lactis subsp. lactis Il1403 transmembrane efflux protein NP_268032.1 1944451 R 272623 CDS NP_268033.1 15673858 1115541 complement(1945945..1946823) 1 NC_002662.1 LysR-family regulator; LysR family transcriptional regulator 1946823 rlrB 1115541 rlrB Lactococcus lactis subsp. lactis Il1403 LysR family transcriptional regulator NP_268033.1 1945945 R 272623 CDS NP_268034.1 15673859 1115542 complement(1946839..1947243) 1 NC_002662.1 MerR family of transcription regulators; transcriptional regulator 1947243 rmeA 1115542 rmeA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268034.1 1946839 R 272623 CDS NP_268035.1 15673860 1115543 complement(1947325..1948635) 1 NC_002662.1 evidence experimental PMID:8439160; degradation of proteins, peptides, and glycopeptides; aminopeptidase C 1948635 pepC 1115543 pepC Lactococcus lactis subsp. lactis Il1403 aminopeptidase C NP_268035.1 1947325 R 272623 CDS NP_268036.1 15673861 1115544 complement(1948764..1949357) 1 NC_002662.1 hypothetical protein 1949357 yteE 1115544 yteE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268036.1 1948764 R 272623 CDS NP_268037.2 30024058 1115545 complement(1949415..1950095) 1 NC_002662.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1950095 pfs 1115545 pfs Lactococcus lactis subsp. lactis Il1403 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_268037.2 1949415 R 272623 CDS NP_268038.1 15673863 1115546 complement(1950128..1950406) 1 NC_002662.1 hypothetical protein 1950406 ytfA 1115546 ytfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268038.1 1950128 R 272623 CDS NP_268039.1 15673864 1115547 complement(1950399..1950983) 1 NC_002662.1 hypothetical protein 1950983 ytfB 1115547 ytfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268039.1 1950399 R 272623 CDS NP_268040.1 15673865 1115548 complement(1951088..1952464) 1 NC_002662.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1952464 glmU 1115548 glmU Lactococcus lactis subsp. lactis Il1403 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_268040.1 1951088 R 272623 CDS NP_268041.1 15673866 1115549 1952692..1953480 1 NC_002662.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 1953480 proC 1115549 proC Lactococcus lactis subsp. lactis Il1403 pyrroline-5-carboxylate reductase NP_268041.1 1952692 D 272623 CDS NP_268042.1 15673867 1115550 complement(1953555..1954502) 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983H 1954502 tra983H 1115550 tra983H Lactococcus lactis subsp. lactis Il1403 transposase of IS983H NP_268042.1 1953555 R 272623 CDS NP_268043.1 15673868 1115551 complement(1954639..1954908) 1 NC_002662.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1954908 rpsO 1115551 rpsO Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S15 NP_268043.1 1954639 R 272623 CDS NP_268044.1 15673869 1115552 complement(1955090..1956973) 1 NC_002662.1 translation; protein modification; serine/threonine protein kinase 1956973 pknB 1115552 pknB Lactococcus lactis subsp. lactis Il1403 serine/threonine protein kinase NP_268044.1 1955090 R 272623 CDS NP_268045.2 30024059 1115553 complement(1956973..1957749) 1 NC_002662.1 translation; protein modification; serine/threonine phosphatase 1957749 pppL 1115553 pppL Lactococcus lactis subsp. lactis Il1403 serine/threonine phosphatase NP_268045.2 1956973 R 272623 CDS NP_268046.1 15673871 1115554 complement(1957830..1959104) 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; similar to RNA-binding Sun protein of Bacillus subtilis, predicted to be rRNA methylase; rRNA methylase 1959104 sunL 1115554 sunL Lactococcus lactis subsp. lactis Il1403 rRNA methylase NP_268046.1 1957830 R 272623 CDS NP_268047.1 15673872 1115555 complement(1959303..1959809) 1 NC_002662.1 similar to a 20 kD protein from sucrose-nisin transposon Tn5306; hypothetical protein 1959809 ytgH 1115555 ytgH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268047.1 1959303 R 272623 CDS YP_008998704.1 574739637 18245220 complement(1959830..1960018) 1 NC_002662.1 membrane protein; hypothetical protein 1960018 18245220 L142734a Lactococcus lactis subsp. lactis Il1403 hypothetical protein YP_008998704.1 1959830 R 272623 CDS NP_268048.1 15673873 1115556 complement(1960029..1960589) 1 NC_002662.1 hypothetical protein 1960589 ytgA 1115556 ytgA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268048.1 1960029 R 272623 CDS NP_268049.1 15673874 1115557 complement(1960617..1960859) 1 NC_002662.1 hypothetical protein 1960859 ytgB 1115557 ytgB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268049.1 1960617 R 272623 CDS NP_268050.1 15673875 1115558 complement(1961034..1961993) 1 NC_002662.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1961993 fmt 1115558 fmt Lactococcus lactis subsp. lactis Il1403 methionyl-tRNA formyltransferase NP_268050.1 1961034 R 272623 CDS NP_268051.2 30024060 1115559 complement(1961990..1962454) 1 NC_002662.1 hypothetical protein 1962454 yteG 1115559 yteG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268051.2 1961990 R 272623 CDS NP_268052.1 15673877 1115560 complement(1962420..1962941) 1 NC_002662.1 similar to ADP-ribose pyrophosphatase or MutT protein of Bacillus subtilis; hypothetical protein 1962941 ytgC 1115560 ytgC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268052.1 1962420 R 272623 CDS NP_268053.1 15673878 1115561 complement(1962954..1963328) 1 NC_002662.1 hypothetical protein 1963328 ytgD 1115561 ytgD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268053.1 1962954 R 272623 CDS NP_268054.1 15673879 1115562 complement(1963387..1965726) 1 NC_002662.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1965726 priA 1115562 priA Lactococcus lactis subsp. lactis Il1403 primosome assembly protein PriA NP_268054.1 1963387 R 272623 CDS NP_268055.1 15673880 1115563 complement(1965865..1966218) 1 NC_002662.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1966218 ytgE 1115563 ytgE Lactococcus lactis subsp. lactis Il1403 DNA-directed RNA polymerase subunit omega NP_268055.1 1965865 R 272623 CDS NP_268056.1 15673881 1115564 complement(1966398..1967015) 1 NC_002662.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1967015 gmk 1115564 gmk Lactococcus lactis subsp. lactis Il1403 guanylate kinase NP_268056.1 1966398 R 272623 CDS NP_268057.1 15673882 1115565 complement(1967163..1968758) 1 NC_002662.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP; phosphodiesterase 1968758 ytgF 1115565 ytgF Lactococcus lactis subsp. lactis Il1403 phosphodiesterase NP_268057.1 1967163 R 272623 CDS NP_268058.1 15673883 1115566 complement(1968989..1969702) 1 NC_002662.1 6-phosphogluconolactonase 1969702 ytgG 1115566 ytgG Lactococcus lactis subsp. lactis Il1403 6-phosphogluconolactonase NP_268058.1 1968989 R 272623 CDS NP_835328.1 30024061 1115567 complement(1969807..1969941) 1 NC_002662.1 simialr to carboxy terminus of S-adenosylmethionine synthetase; hypothetical protein 1969941 1115567 L200068 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835328.1 1969807 R 272623 CDS NP_268059.1 15673884 1115568 complement(1969978..1971177) 1 NC_002662.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1971177 metK 1115568 metK Lactococcus lactis subsp. lactis Il1403 S-adenosylmethionine synthetase NP_268059.1 1969978 R 272623 CDS NP_268060.1 15673885 1115570 1972948..1973700 1 NC_002662.1 COG says Biotin-(acetyl-CoA carboxylase) ligase; bifunctional biotin-[acetylCoA carboxylase] synthetase/ DNA-binding transcriptional repressor 1973700 birA2 1115570 birA2 Lactococcus lactis subsp. lactis Il1403 bifunctional biotin-[acetylCoA carboxylase] synthetase/ DNA-binding transcriptional repressor NP_268060.1 1972948 D 272623 CDS NP_268061.1 15673886 1115571 complement(1973807..1974271) 1 NC_002662.1 similar to YvlC protein of Bacillus subtilis; probably stress-responsive transcription regulator, evidenced by COGnitor; hypothetical protein 1974271 ythA 1115571 ythA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268061.1 1973807 R 272623 CDS NP_268062.1 15673887 1115572 complement(1974300..1974503) 1 NC_002662.1 similar to YvlC protein of Bacillus subtilis; probably stress-responsive transcription regulator, evidenced by COGnitor; hypothetical protein 1974503 ythB 1115572 ythB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268062.1 1974300 R 272623 CDS NP_268063.1 15673888 1115573 complement(1974565..1975680) 1 NC_002662.1 similar to YvlB of Bacillus subtilis; hypothetical protein 1975680 ythC 1115573 ythC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268063.1 1974565 R 272623 CDS NP_268064.1 15673889 1115574 complement(1975894..1977321) 1 NC_002662.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis; N-acetylmuramoyl-L-alanine amidase 1977321 acmB 1115574 acmB Lactococcus lactis subsp. lactis Il1403 N-acetylmuramoyl-L-alanine amidase NP_268064.1 1975894 R 272623 CDS NP_268065.1 15673890 1115575 complement(1977927..1978874) 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983I 1978874 tra983I 1115575 tra983I Lactococcus lactis subsp. lactis Il1403 transposase of IS983I NP_268065.1 1977927 R 272623 CDS NP_268066.1 15673891 1115576 complement(1979402..1980298) 1 NC_002662.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 1980298 fbaA 1115576 fbaA Lactococcus lactis subsp. lactis Il1403 fructose-bisphosphate aldolase NP_268066.1 1979402 R 272623 CDS NP_268067.1 15673892 1115577 complement(1986364..1987023) 1 NC_002662.1 hypothetical protein 1987023 ytiA 1115577 ytiA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268067.1 1986364 R 272623 CDS NP_268068.1 15673893 1115578 complement(1987130..1989070) 1 NC_002662.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1989070 thrS 1115578 thrS Lactococcus lactis subsp. lactis Il1403 threonyl-tRNA synthetase NP_268068.1 1987130 R 272623 CDS NP_268069.1 15673894 1115579 complement(1989614..1989931) 1 NC_002662.1 hypothetical protein 1989931 ytjA 1115579 ytjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268069.1 1989614 R 272623 CDS NP_268070.1 15673895 1115581 complement(1991357..1991965) 1 NC_002662.1 hypothetical protein 1991965 ytjD 1115581 ytjD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268070.1 1991357 R 272623 CDS NP_268071.1 15673896 1115582 complement(1992107..1992742) 1 NC_002662.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1992742 upp 1115582 upp Lactococcus lactis subsp. lactis Il1403 uracil phosphoribosyltransferase NP_268071.1 1992107 R 272623 CDS NP_268072.1 15673897 1115583 complement(1992968..1994107) 1 NC_002662.1 transort and binding protein, cations; Na+/H+ antiporter 1994107 nah 1115583 nah Lactococcus lactis subsp. lactis Il1403 Na+/H+ antiporter NP_268072.1 1992968 R 272623 CDS NP_268073.1 15673898 1115584 complement(1994162..1995325) 1 NC_002662.1 energy metabolism, amino acids and amines; belongs to class-II of pyridoxal-phosphate-dependent aminotransferases; MALY/PATB subfamily; probably methionine specific aminotransferase; aminotransferase 1995325 ytjE 1115584 ytjE Lactococcus lactis subsp. lactis Il1403 aminotransferase NP_268073.1 1994162 R 272623 CDS NP_268074.1 15673899 1115585 complement(1995572..1996660) 1 NC_002662.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1996660 metB1 1115585 metB1 Lactococcus lactis subsp. lactis Il1403 cystathionine gamma-synthase NP_268074.1 1995572 R 272623 CDS NP_268075.1 15673900 1115586 complement(1996691..1997656) 1 NC_002662.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1997656 metA 1115586 metA Lactococcus lactis subsp. lactis Il1403 homoserine O-succinyltransferase NP_268075.1 1996691 R 272623 CDS NP_268076.1 15673901 1115587 complement(1997806..1998366) 1 NC_002662.1 hypothetical protein 1998366 ytjF 1115587 ytjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268076.1 1997806 R 272623 CDS NP_268078.1 15673903 1115589 complement(1999580..2000287) 1 NC_002662.1 hypothetical protein 2000287 ytjH 1115589 ytjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268078.1 1999580 R 272623 CDS NP_268079.1 15673904 1115590 complement(2000601..2001545) 1 NC_002662.1 similar to CMP-binding-factor 1 of S.aureus; hypothetical protein 2001545 yuaA 1115590 yuaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268079.1 2000601 R 272623 CDS NP_268080.1 15673905 1115591 complement(2001792..2003096) 1 NC_002662.1 hypothetical protein 2003096 yuaB 1115591 yuaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268080.1 2001792 R 272623 CDS NP_268081.1 15673906 1115592 complement(2003188..2003838) 1 NC_002662.1 pentose phosphate pathway; ribulose-phosphate 3-epimerase 2003838 rpe 1115592 rpe Lactococcus lactis subsp. lactis Il1403 ribulose-phosphate 3-epimerase NP_268081.1 2003188 R 272623 CDS NP_268082.1 15673907 1115593 complement(2003897..2004154) 1 NC_002662.1 hypothetical protein 2004154 yuaC 1115593 yuaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268082.1 2003897 R 272623 CDS NP_268083.1 15673908 1115594 complement(2004383..2005306) 1 NC_002662.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 2005306 yuaD 1115594 yuaD Lactococcus lactis subsp. lactis Il1403 ribosome-associated GTPase NP_268083.1 2004383 R 272623 CDS NP_268084.2 30024062 1115595 complement(2005366..2006430) 1 NC_002662.1 similar to extracellular protein Exp1 precursor; hypothetical protein 2006430 yuaE 1115595 yuaE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268084.2 2005366 R 272623 CDS NP_268085.1 15673910 1115596 complement(2006657..2009050) 1 NC_002662.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2009050 pheT 1115596 pheT Lactococcus lactis subsp. lactis Il1403 phenylalanyl-tRNA synthetase subunit beta NP_268085.1 2006657 R 272623 CDS NP_268086.1 15673911 1115597 complement(2009087..2010127) 1 NC_002662.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2010127 pheS 1115597 pheS Lactococcus lactis subsp. lactis Il1403 phenylalanyl-tRNA synthetase subunit alpha NP_268086.1 2009087 R 272623 CDS NP_268087.1 15673912 1115598 2010581..2011114 1 NC_002662.1 energy metabolism, amino acids and amines; specificity of the enzyme is not clearly defined; phenolic acid decarboxylase 2011114 pdc 1115598 pdc Lactococcus lactis subsp. lactis Il1403 phenolic acid decarboxylase NP_268087.1 2010581 D 272623 CDS NP_268088.1 15673913 1115599 2011426..2012373 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983J 2012373 tra983J 1115599 tra983J Lactococcus lactis subsp. lactis Il1403 transposase of IS983J NP_268088.1 2011426 D 272623 CDS NP_268089.1 15673914 1115600 complement(2013685..2014605) 1 NC_002662.1 prophage ps3 protein 01 2014605 ps301 1115600 ps301 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 01 NP_268089.1 2013685 R 272623 CDS NP_268090.1 15673915 1115601 complement(2014617..2014913) 1 NC_002662.1 prophage ps3 protein 02 2014913 ps302 1115601 ps302 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 02 NP_268090.1 2014617 R 272623 CDS NP_268091.1 15673916 1115602 complement(2015102..2015281) 1 NC_002662.1 prophage ps3 protein 03 2015281 ps303 1115602 ps303 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 03 NP_268091.1 2015102 R 272623 CDS NP_268092.1 15673917 1115603 complement(2015473..2015703) 1 NC_002662.1 prophage ps3 protein 04 2015703 ps304 1115603 ps304 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 04 NP_268092.1 2015473 R 272623 CDS NP_268093.1 15673918 1115604 complement(2015846..2016352) 1 NC_002662.1 prophage ps3 protein 05 2016352 ps305 1115604 ps305 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 05 NP_268093.1 2015846 R 272623 CDS NP_835329.1 30024063 1115605 complement(2016511..2016648) 1 NC_002662.1 similar to bacteriophage bIL311 Orf16; hypothetical protein 2016648 1115605 L200071 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835329.1 2016511 R 272623 CDS NP_268094.1 15673919 1115606 2016951..2017898 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983K 2017898 tra983K 1115606 tra983K Lactococcus lactis subsp. lactis Il1403 transposase of IS983K NP_268094.1 2016951 D 272623 CDS NP_268095.1 15673920 1115607 complement(2017986..2018348) 1 NC_002662.1 prophage ps3 protein 06 2018348 ps306 1115607 ps306 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 06 NP_268095.1 2017986 R 272623 CDS NP_268096.1 15673921 1115608 complement(2018365..2018937) 1 NC_002662.1 prophage ps3 protein 07 2018937 ps307 1115608 ps307 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 07 NP_268096.1 2018365 R 272623 CDS NP_268097.1 15673922 1115609 complement(2019099..2019305) 1 NC_002662.1 prophage ps3 protein 08 2019305 ps308 1115609 ps308 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 08 NP_268097.1 2019099 R 272623 CDS NP_268098.1 15673923 1115610 complement(2019324..2019506) 1 NC_002662.1 prophage ps3 protein 09 2019506 ps309 1115610 ps309 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 09 NP_268098.1 2019324 R 272623 CDS NP_268099.1 15673924 1115611 complement(2019875..2020189) 1 NC_002662.1 prophage ps3 protein 10 2020189 ps310 1115611 ps310 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 10 NP_268099.1 2019875 R 272623 CDS NP_268100.1 15673925 1115612 complement(2020102..2021571) 1 NC_002662.1 similar to a bacteriophage resistance protein from Lactococcus lactis; prophage ps3 protein 11 2021571 ps311 1115612 ps311 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 11 NP_268100.1 2020102 R 272623 CDS NP_268101.1 15673926 1115613 complement(2021582..2021851) 1 NC_002662.1 prophage ps3 protein 12 2021851 ps312 1115613 ps312 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 12 NP_268101.1 2021582 R 272623 CDS NP_835330.1 30024064 1115614 complement(2021848..2022000) 1 NC_002662.1 similar to bacteriophage bIL311 Orf7; hypothetical protein 2022000 1115614 L200072 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835330.1 2021848 R 272623 CDS NP_835331.1 30024065 1115615 complement(2022088..2022252) 1 NC_002662.1 similar to bacteriophage bIL311 Orf6; hypothetical protein 2022252 1115615 L200073 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835331.1 2022088 R 272623 CDS NP_835332.1 30024066 1115616 complement(2022254..2022424) 1 NC_002662.1 similar to bacteriophage bIL311 Orf5; hypothetical protein 2022424 1115616 L200074 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835332.1 2022254 R 272623 CDS NP_835333.1 30024067 1115617 complement(2022504..2022629) 1 NC_002662.1 similar to bacteriophage bIL311 Orf4; hypothetical protein 2022629 1115617 L200075 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835333.1 2022504 R 272623 CDS NP_268102.1 15673927 1115618 complement(2022663..2023178) 1 NC_002662.1 prophage ps3 protein 13 2023178 ps313 1115618 ps313 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 13 NP_268102.1 2022663 R 272623 CDS NP_268103.1 15673928 1115619 complement(2023293..2023499) 1 NC_002662.1 transcription regulator; similar to cro-like repressor of bacteriophage phig1e; prophage ps3 protein 14 2023499 ps314 1115619 ps314 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 14 NP_268103.1 2023293 R 272623 CDS NP_268104.1 15673929 1115620 2023648..2024355 1 NC_002662.1 prophage ps3 protein 15 2024355 ps315 1115620 ps315 Lactococcus lactis subsp. lactis Il1403 prophage ps3 protein 15 NP_268104.1 2023648 D 272623 CDS NP_268105.1 15673930 1115621 2024436..2025635 1 NC_002662.1 prophage ps3 protein 16; integrase 2025635 ps316 1115621 ps316 Lactococcus lactis subsp. lactis Il1403 integrase NP_268105.1 2024436 D 272623 CDS NP_268106.1 15673931 1115622 2025839..2026378 1 NC_002662.1 probably transcription regulator, evidenced by COGnitor; hypothetical protein 2026378 yucF 1115622 yucF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268106.1 2025839 D 272623 CDS NP_268107.1 15673932 1115623 2026545..2028023 1 NC_002662.1 degradation of polysaccharides; hydrolysis of the beta-1,4 linkages of N-acetyl-D-glucosamine polymers of chitin; chitinase 2028023 chiA 1115623 chiA Lactococcus lactis subsp. lactis Il1403 chitinase NP_268107.1 2026545 D 272623 CDS NP_268108.1 15673933 1115624 2028043..2028705 1 NC_002662.1 central intermediary metabolism; degradation of polysaccharides; probably a secreted chitinase; chitin binding protein 2028705 yucG 1115624 yucG Lactococcus lactis subsp. lactis Il1403 chitin binding protein NP_268108.1 2028043 D 272623 CDS NP_268109.1 15673934 1115625 complement(2028748..2030040) 1 NC_002662.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 2030040 purA 1115625 purA Lactococcus lactis subsp. lactis Il1403 adenylosuccinate synthetase NP_268109.1 2028748 R 272623 CDS NP_268110.1 15673935 1115626 complement(2030313..2030933) 1 NC_002662.1 transport and binding protein; transporter 2030933 yudA 1115626 yudA Lactococcus lactis subsp. lactis Il1403 transporter NP_268110.1 2030313 R 272623 CDS NP_835334.1 30024068 1115627 complement(2031192..2031350) 1 NC_002662.1 similar to bacteriophage bIL310 Orf3; hypothetical protein 2031350 1115627 L200076 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835334.1 2031192 R 272623 CDS NP_268111.1 15673936 1115628 complement(2031520..2031987) 1 NC_002662.1 hypothetical protein 2031987 yudB 1115628 yudB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268111.1 2031520 R 272623 CDS NP_268112.1 15673937 1115629 complement(2032053..2032730) 1 NC_002662.1 hypothetical protein 2032730 yudC 1115629 yudC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268112.1 2032053 R 272623 CDS NP_268113.1 15673938 1115630 complement(2032821..2033324) 1 NC_002662.1 hypothetical protein 2033324 yudD 1115630 yudD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268113.1 2032821 R 272623 CDS NP_268114.1 15673939 1115631 complement(2033404..2033655) 1 NC_002662.1 hypothetical protein 2033655 yudE 1115631 yudE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268114.1 2033404 R 272623 CDS NP_268115.1 15673940 1115632 complement(2033751..2034074) 1 NC_002662.1 hypothetical protein 2034074 yudF 1115632 yudF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268115.1 2033751 R 272623 CDS NP_268116.2 30024069 1115633 2034313..2035179 1 NC_002662.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2035179 hslO 1115633 hslO Lactococcus lactis subsp. lactis Il1403 Hsp33-like chaperonin NP_268116.2 2034313 D 272623 CDS NP_268117.1 15673942 1115634 2035234..2035755 1 NC_002662.1 dihydrofolate reductase, evidenced by COGnitor; hypothetical protein 2035755 yudH 1115634 yudH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268117.1 2035234 D 272623 CDS NP_268118.1 15673943 1115635 2035883..2036887 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 2036887 yudI 1115635 yudI Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_268118.1 2035883 D 272623 CDS NP_268119.1 15673944 1115636 complement(2037253..2038137) 1 NC_002662.1 similar to YpjC protein of Bacillus subtilis; hypothetical protein 2038137 yudJ 1115636 yudJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268119.1 2037253 R 272623 CDS NP_268120.1 15673945 1115637 complement(2038287..2039135) 1 NC_002662.1 similar to YpjC protein of Bacillus subtilis; hypothetical protein 2039135 yudK 1115637 yudK Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268120.1 2038287 R 272623 CDS NP_268121.1 15673946 1115638 complement(2039261..2040103) 1 NC_002662.1 similar to YitT protein of Bacillus subtilis; hypothetical protein 2040103 yudL 1115638 yudL Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268121.1 2039261 R 272623 CDS NP_268122.1 15673947 1115639 complement(2040170..2041942) 1 NC_002662.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2041942 aspS 1115639 aspS Lactococcus lactis subsp. lactis Il1403 aspartyl-tRNA synthetase NP_268122.1 2040170 R 272623 CDS NP_268124.1 15673949 1115641 complement(2042397..2043689) 1 NC_002662.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2043689 hisS 1115641 hisS Lactococcus lactis subsp. lactis Il1403 histidyl-tRNA synthetase NP_268124.1 2042397 R 272623 CDS NP_268125.1 15673950 1115642 complement(2044002..2045162) 1 NC_002662.1 similar to positive regulator GadR of Lactococcus lactis; hypothetical protein 2045162 yueB 1115642 yueB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268125.1 2044002 R 272623 CDS NP_268126.1 15673951 1115643 complement(2045406..2045981) 1 NC_002662.1 hypothetical protein 2045981 yueC 1115643 yueC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268126.1 2045406 R 272623 CDS NP_268127.1 15673952 1115644 complement(2046241..2046813) 1 NC_002662.1 membranes, lipoproteins, and porins; catalyzes the committed step to the synthesis of the acidic phospholipids; integral membrance protein; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2046813 pgsA 1115644 pgsA Lactococcus lactis subsp. lactis Il1403 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_268127.1 2046241 R 272623 CDS NP_268128.1 15673953 1115645 complement(2046854..2047750) 1 NC_002662.1 hypothetical protein 2047750 yueD 1115645 yueD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268128.1 2046854 R 272623 CDS NP_268129.1 15673954 1115646 complement(2047962..2049194) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; similar to different proteases; protease 2049194 yueE 1115646 yueE Lactococcus lactis subsp. lactis Il1403 protease NP_268129.1 2047962 R 272623 CDS NP_268130.1 15673955 1115647 complement(2049235..2050491) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; similar to several proteases; protease 2050491 yueF 1115647 yueF Lactococcus lactis subsp. lactis Il1403 protease NP_268130.1 2049235 R 272623 CDS NP_268131.1 15673956 1115648 2050719..2051081 1 NC_002662.1 hypothetical protein 2051081 yufA 1115648 yufA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268131.1 2050719 D 272623 CDS NP_268132.1 15673957 1115649 2051081..2052157 1 NC_002662.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2052157 recF 1115649 recF Lactococcus lactis subsp. lactis Il1403 recombination protein F NP_268132.1 2051081 D 272623 CDS NP_268133.1 15673958 1115650 complement(2052244..2052612) 1 NC_002662.1 central intermediary metabolism; third step in the catabolism of protocatechuate to succinate and acetyl-CoA in the beta-ketoadipate pathway; gamma-carboxymuconolactone decarboxylase 2052612 pcaC 1115650 pcaC Lactococcus lactis subsp. lactis Il1403 gamma-carboxymuconolactone decarboxylase NP_268133.1 2052244 R 272623 CDS NP_268134.1 15673959 1115651 2052690..2053067 1 NC_002662.1 MerR family of transcription regulators; transcriptional regulator 2053067 rmeD 1115651 rmeD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268134.1 2052690 D 272623 CDS NP_268135.1 15673960 1115652 complement(2053080..2054024) 1 NC_002662.1 hypothetical protein 2054024 yufC 1115652 yufC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268135.1 2053080 R 272623 CDS NP_268136.1 15673961 1115653 complement(2054147..2055127) 1 NC_002662.1 galactose metabolism; UDP-glucose 4-epimerase 2055127 galE 1115653 galE Lactococcus lactis subsp. lactis Il1403 UDP-glucose 4-epimerase NP_268136.1 2054147 R 272623 CDS NP_268137.2 30024070 1115654 complement(2055179..2058175) 1 NC_002662.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 2058175 lacZ 1115654 lacZ Lactococcus lactis subsp. lactis Il1403 beta-D-galactosidase NP_268137.2 2055179 R 272623 CDS NP_268139.1 15673964 1115657 complement(2058844..2060325) 1 NC_002662.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 2060325 galT 1115657 galT Lactococcus lactis subsp. lactis Il1403 galactose-1-phosphate uridylyltransferase NP_268139.1 2058844 R 272623 CDS NP_268140.1 15673965 1115658 complement(2060499..2061698) 1 NC_002662.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 2061698 galK 1115658 galK Lactococcus lactis subsp. lactis Il1403 galactokinase NP_268140.1 2060499 R 272623 CDS NP_268141.1 15673966 1115659 complement(2061725..2062744) 1 NC_002662.1 galactose metabolism; aldose 1-epimerase 2062744 galM 1115659 galM Lactococcus lactis subsp. lactis Il1403 aldose 1-epimerase NP_268141.1 2061725 R 272623 CDS NP_268142.1 15673967 1115661 complement(2064540..2065274) 1 NC_002662.1 RpiR family of transcription regulators; transcriptional regulator 2065274 yugA 1115661 yugA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268142.1 2064540 R 272623 CDS NP_268143.1 15673968 1115662 2065403..2066266 1 NC_002662.1 aerobic energy metabolism; oxidoreductase 2066266 yugB 1115662 yugB Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_268143.1 2065403 D 272623 CDS NP_268144.1 15673969 1115663 complement(2066475..2067614) 1 NC_002662.1 NadR family of transcription regulators; transcriptional regulator 2067614 nadR 1115663 nadR Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268144.1 2066475 R 272623 CDS NP_268145.1 15673970 1115664 complement(2067601..2068578) 1 NC_002662.1 aerobic energy metabolism; dehydrogenase 2068578 yugC 1115664 yugC Lactococcus lactis subsp. lactis Il1403 dehydrogenase NP_268145.1 2067601 R 272623 CDS NP_268146.1 15673971 1115665 complement(2068776..2070068) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; protease 2070068 yugD 1115665 yugD Lactococcus lactis subsp. lactis Il1403 protease NP_268146.1 2068776 R 272623 CDS NP_268147.1 15673972 1115666 complement(2070324..2070491) 1 NC_002662.1 hypothetical protein 2070491 yuhA 1115666 yuhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268147.1 2070324 R 272623 CDS NP_268148.1 15673973 1115667 complement(2070628..2071551) 1 NC_002662.1 degradation of proteins, peptides, and glycopeptides; protease 2071551 yuhB 1115667 yuhB Lactococcus lactis subsp. lactis Il1403 protease NP_268148.1 2070628 R 272623 CDS NP_268149.1 15673974 1115668 2071772..2072053 1 NC_002662.1 hypothetical protein 2072053 yuhC 1115668 yuhC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268149.1 2071772 D 272623 CDS NP_268150.1 15673975 1115669 complement(2072076..2072897) 1 NC_002662.1 probably a SAM-dependent RNA methyltransferase, evidenced by COGnitor; hypothetical protein 2072897 yuhD 1115669 yuhD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268150.1 2072076 R 272623 CDS NP_268151.1 15673976 1115670 2073015..2073641 1 NC_002662.1 hypothetical protein 2073641 yuhE 1115670 yuhE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268151.1 2073015 D 272623 CDS NP_268152.1 15673977 1115671 complement(2073681..2074700) 1 NC_002662.1 transport and binding protein; similar to EcsB of Bacillus subtilis involved in the control of levels of exoamylase and other exoenzymes; ABC transporter permease 2074700 ecsB 1115671 ecsB Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_268152.1 2073681 R 272623 CDS NP_268153.1 15673978 1115672 complement(2074693..2075463) 1 NC_002662.1 transport and binding protein; similar to EcsA of Bacillus subtilis controlling levels of exoamylase and other exoenzymes; ABC transporter ATP-binding protein 2075463 ecsA 1115672 ecsA Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_268153.1 2074693 R 272623 CDS NP_268154.1 15673979 1115673 complement(2075482..2077335) 1 NC_002662.1 hypothetical protein 2077335 yuhH 1115673 yuhH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268154.1 2075482 R 272623 CDS NP_268155.1 15673980 1115674 2077566..2077967 1 NC_002662.1 hypothetical protein 2077967 yuhI 1115674 yuhI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268155.1 2077566 D 272623 CDS NP_268156.1 15673981 1115675 2077980..2078201 1 NC_002662.1 hypothetical protein 2078201 yuhJ 1115675 yuhJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268156.1 2077980 D 272623 CDS NP_268157.1 15673982 1115676 complement(2078636..2079325) 1 NC_002662.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 2079325 rplA 1115676 rplA Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L1 NP_268157.1 2078636 R 272623 CDS NP_268158.1 15673983 1115677 complement(2079621..2080046) 1 NC_002662.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 2080046 rplK 1115677 rplK Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L11 NP_268158.1 2079621 R 272623 CDS NP_268159.1 15673984 1115678 2080271..2082148 1 NC_002662.1 transport and binding protein, cations; similar to cadmium resistance protein of Lactococcus lactis; metal transporting ATPase 2082148 yuiA 1115678 yuiA Lactococcus lactis subsp. lactis Il1403 metal transporting ATPase NP_268159.1 2080271 D 272623 CDS NP_268160.1 15673985 1115679 2082212..2082880 1 NC_002662.1 CRP/FNR family of transcription regulators; transcriptional regulator 2082880 rcfA 1115679 rcfA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268160.1 2082212 D 272623 CDS NP_268161.1 15673986 1115680 2083063..2084010 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983L 2084010 tra983L 1115680 tra983L Lactococcus lactis subsp. lactis Il1403 transposase of IS983L NP_268161.1 2083063 D 272623 CDS NP_268162.1 15673987 1115681 complement(2084031..2084240) 1 NC_002662.1 similar to YozE of Bacillus subtilis; hypothetical protein 2084240 yuiB 1115681 yuiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268162.1 2084031 R 272623 CDS NP_268163.1 15673988 1115682 complement(2084276..2084794) 1 NC_002662.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 2084794 pmsR 1115682 pmsR Lactococcus lactis subsp. lactis Il1403 methionine sulfoxide reductase A NP_268163.1 2084276 R 272623 CDS NP_268164.1 15673989 1115683 complement(2084969..2085826) 1 NC_002662.1 similar to YitL protein of Bacillus subtilis; hypothetical protein 2085826 yuiC 1115683 yuiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268164.1 2084969 R 272623 CDS NP_268165.1 15673990 1115684 complement(2085872..2086330) 1 NC_002662.1 hypothetical protein 2086330 yuiD 1115684 yuiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268165.1 2085872 R 272623 CDS NP_268166.1 15673991 1115685 complement(2086423..2086980) 1 NC_002662.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 2086980 frr 1115685 frr Lactococcus lactis subsp. lactis Il1403 ribosome recycling factor NP_268166.1 2086423 R 272623 CDS NP_268167.1 15673992 1115686 complement(2087192..2087908) 1 NC_002662.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 2087908 pyrH 1115686 pyrH Lactococcus lactis subsp. lactis Il1403 uridylate kinase NP_268167.1 2087192 R 272623 CDS NP_268168.1 15673993 1115687 complement(2087993..2088445) 1 NC_002662.1 hypothetical protein 2088445 yuiE 1115687 yuiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268168.1 2087993 R 272623 CDS NP_268169.1 15673994 1115688 complement(2088579..2089766) 1 NC_002662.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2089766 ackA2 1115688 ackA2 Lactococcus lactis subsp. lactis Il1403 acetate kinase NP_268169.1 2088579 R 272623 CDS NP_268170.1 15673995 1115689 complement(2089923..2091110) 1 NC_002662.1 fermentation; first of two steps in the conversion of acetate to acetyl-CoA; acetate kinase 2091110 ackA1 1115689 ackA1 Lactococcus lactis subsp. lactis Il1403 acetate kinase NP_268170.1 2089923 R 272623 CDS NP_268171.1 15673996 1115690 complement(2091305..2092243) 1 NC_002662.1 hypothetical protein 2092243 yujA 1115690 yujA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268171.1 2091305 R 272623 CDS NP_268172.1 15673997 1115691 complement(2092679..2094520) 1 NC_002662.1 GTP-binding protein; BipA; hypothetical protein 2094520 typA 1115691 typA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268172.1 2092679 R 272623 CDS NP_268173.1 15673998 1115692 complement(2094699..2095157) 1 NC_002662.1 hypothetical protein 2095157 yujB 1115692 yujB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268173.1 2094699 R 272623 CDS NP_268174.1 15673999 1115693 complement(2095173..2095946) 1 NC_002662.1 hypothetical protein 2095946 yujC 1115693 yujC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268174.1 2095173 R 272623 CDS NP_268175.1 15674000 1115694 complement(2096283..2096909) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 2096909 yujD 1115694 yujD Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_268175.1 2096283 R 272623 CDS NP_268176.1 15674001 1115695 complement(2096910..2098892) 1 NC_002662.1 hypothetical protein 2098892 yujE 1115695 yujE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268176.1 2096910 R 272623 CDS NP_268177.1 15674002 1115696 complement(2098896..2099222) 1 NC_002662.1 hypothetical protein 2099222 yujF 1115696 yujF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268177.1 2098896 R 272623 CDS NP_268178.1 15674003 1115697 complement(2099522..2100250) 1 NC_002662.1 hypothetical protein 2100250 yujG 1115697 yujG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268178.1 2099522 R 272623 CDS NP_268179.1 15674004 1115698 2100443..2100664 1 NC_002662.1 hypothetical protein 2100664 yvaA 1115698 yvaA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268179.1 2100443 D 272623 CDS NP_268180.1 15674005 1115699 2100698..2101669 1 NC_002662.1 energy metabolism, sugars; glucokinase 2101669 glk 1115699 glk Lactococcus lactis subsp. lactis Il1403 glucokinase NP_268180.1 2100698 D 272623 CDS NP_268181.1 15674006 1115700 2101672..2102058 1 NC_002662.1 hypothetical protein 2102058 yvaB 1115700 yvaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268181.1 2101672 D 272623 CDS NP_268182.1 15674007 1115701 complement(2102141..2102587) 1 NC_002662.1 adaptations and atypical conditions; known in other bacteria also as starvation-inducible DNA-binding protein Dps; non-heme iron-binding ferritin 2102587 dpsA 1115701 dpsA Lactococcus lactis subsp. lactis Il1403 non-heme iron-binding ferritin NP_268182.1 2102141 R 272623 CDS NP_268183.1 15674008 1115702 complement(2102725..2103564) 1 NC_002662.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1; transposase of IS981J 2103564 tra981J 1115702 tra981J Lactococcus lactis subsp. lactis Il1403 transposase of IS981J NP_268183.1 2102725 R 272623 CDS NP_268184.1 15674009 1115703 complement(2103576..2103836) 1 NC_002662.1 transposon related function; orf1 of IS981; transposase 2103836 yuiI 1115703 yuiI Lactococcus lactis subsp. lactis Il1403 transposase NP_268184.1 2103576 R 272623 CDS NP_268185.1 15674010 1115704 2103981..2104646 1 NC_002662.1 transformation; required for processind and membrane assembling of ComG proteins.; type 4 prepilin-like protein specific leader peptidase 2104646 comC 1115704 comC Lactococcus lactis subsp. lactis Il1403 type 4 prepilin-like protein specific leader peptidase NP_268185.1 2103981 D 272623 CDS NP_268186.1 15674011 1115705 complement(2104597..2105688) 1 NC_002662.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 2105688 dinP 1115705 dinP Lactococcus lactis subsp. lactis Il1403 DNA polymerase IV NP_268186.1 2104597 R 272623 CDS NP_268187.1 15674012 1115706 complement(2105767..2106258) 1 NC_002662.1 hypothetical protein 2106258 yvaD 1115706 yvaD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268187.1 2105767 R 272623 CDS NP_268188.1 15674013 1115707 complement(2106337..2107830) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; arginine/ornitine antiporter 2107830 arcD2 1115707 arcD2 Lactococcus lactis subsp. lactis Il1403 arginine/ornitine antiporter NP_268188.1 2106337 R 272623 CDS NP_268189.1 15674014 1115708 complement(2108022..2109152) 1 NC_002662.1 associated with arginine deiminase pathway genes; probably functions in arginine catabolism; transaminase 2109152 arcT 1115708 arcT Lactococcus lactis subsp. lactis Il1403 transaminase NP_268189.1 2108022 R 272623 CDS NP_268190.1 15674015 1115709 complement(2109416..2110360) 1 NC_002662.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2110360 arcC2 1115709 arcC2 Lactococcus lactis subsp. lactis Il1403 carbamate kinase NP_268190.1 2109416 R 272623 CDS NP_268191.1 15674016 1115710 complement(2110392..2111336) 1 NC_002662.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2111336 arcC1 1115710 arcC1 Lactococcus lactis subsp. lactis Il1403 carbamate kinase NP_268191.1 2110392 R 272623 CDS NP_268192.1 15674017 1115711 complement(2111456..2112928) 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; arginine/ornitine antiporter 2112928 arcD1 1115711 arcD1 Lactococcus lactis subsp. lactis Il1403 arginine/ornitine antiporter NP_268192.1 2111456 R 272623 CDS NP_268193.1 15674018 1115712 complement(2113059..2114123) 1 NC_002662.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2114123 arcB 1115712 arcB Lactococcus lactis subsp. lactis Il1403 ornithine carbamoyltransferase NP_268193.1 2113059 R 272623 CDS NP_268194.1 15674019 1115713 complement(2114307..2115539) 1 NC_002662.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2115539 arcA 1115713 arcA Lactococcus lactis subsp. lactis Il1403 arginine deiminase NP_268194.1 2114307 R 272623 CDS NP_268195.1 15674020 1115714 complement(2115841..2117535) 1 NC_002662.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2117535 argS 1115714 argS Lactococcus lactis subsp. lactis Il1403 arginyl-tRNA synthetase NP_268195.1 2115841 R 272623 CDS NP_268196.1 15674021 1115715 2117603..2118061 1 NC_002662.1 regulator of arginine degradation pathway; arginine catabolic regulator 2118061 argR 1115715 argR Lactococcus lactis subsp. lactis Il1403 arginine catabolic regulator NP_268196.1 2117603 D 272623 CDS NP_268197.2 161723236 1115716 complement(2118244..2119575) 1 NC_002662.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 2119575 murC 1115716 murC Lactococcus lactis subsp. lactis Il1403 UDP-N-acetylmuramate--L-alanine ligase NP_268197.2 2118244 R 272623 CDS NP_268198.1 15674023 1115717 complement(2119778..2120371) 1 NC_002662.1 hypothetical protein 2120371 yvcA 1115717 yvcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268198.1 2119778 R 272623 CDS NP_268199.1 15674024 1115718 complement(2120587..2123691) 1 NC_002662.1 DNA replication, restriction, modification, recombination, and repair; SWI/SNF family helicase 2123691 snf 1115718 snf Lactococcus lactis subsp. lactis Il1403 SWI/SNF family helicase NP_268199.1 2120587 R 272623 CDS NP_268200.1 15674025 1115719 complement(2123945..2128297) 1 NC_002662.1 hypothetical protein 2128297 yvcC 1115719 yvcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268200.1 2123945 R 272623 CDS NP_268201.1 15674026 1115720 complement(2128720..2130423) 1 NC_002662.1 aerobic energy metabolism; pyruvate oxidase 2130423 poxL 1115720 poxL Lactococcus lactis subsp. lactis Il1403 pyruvate oxidase NP_268201.1 2128720 R 272623 CDS NP_268202.1 15674027 1115721 complement(2130620..2131606) 1 NC_002662.1 hypothetical protein 2131606 yvdA 1115721 yvdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268202.1 2130620 R 272623 CDS NP_268203.1 15674028 1115722 complement(2131679..2132458) 1 NC_002662.1 hypothetical protein 2132458 yvdB 1115722 yvdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268203.1 2131679 R 272623 CDS NP_268204.1 15674029 1115723 2132812..2133597 1 NC_002662.1 hypothetical protein 2133597 yvdC 1115723 yvdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268204.1 2132812 D 272623 CDS NP_268205.1 15674030 1115724 complement(2133640..2134509) 1 NC_002662.1 transport and binding protein, carbohydrates; organic alcohols and acids; similar to glycerol uptake facilitator GlpF of Bacillus subtilis; transmembrance channel MIP family; transporter 2134509 yvdD 1115724 yvdD Lactococcus lactis subsp. lactis Il1403 transporter NP_268205.1 2133640 R 272623 CDS NP_268206.1 15674031 1115725 2134681..2136972 1 NC_002662.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 2136972 pepXP 1115725 pepXP Lactococcus lactis subsp. lactis Il1403 x-prolyl-dipeptidyl aminopeptidase NP_268206.1 2134681 D 272623 CDS NP_268207.1 15674032 1115726 2136974..2137684 1 NC_002662.1 hypothetical protein 2137684 yvdE 1115726 yvdE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268207.1 2136974 D 272623 CDS NP_268208.1 15674033 1115727 2137834..2138676 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; amino acid ABC transporter substrate binding protein 2138676 yvdF 1115727 yvdF Lactococcus lactis subsp. lactis Il1403 amino acid ABC transporter substrate binding protein NP_268208.1 2137834 D 272623 CDS NP_268209.1 15674034 1115728 complement(2138764..2139897) 1 NC_002662.1 pyridine nucleotides; may be mercuric reductase; pyridine nucleotide-disulfide oxidoreductase 2139897 yvdG 1115728 yvdG Lactococcus lactis subsp. lactis Il1403 pyridine nucleotide-disulfide oxidoreductase NP_268209.1 2138764 R 272623 CDS NP_835336.1 30024072 1115729 complement(2139894..2140088) 1 NC_002662.1 hypothetical protein 2140088 1115729 L200079 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_835336.1 2139894 R 272623 CDS NP_268210.1 15674035 1115730 complement(2140195..2141646) 1 NC_002662.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2141646 gltX 1115730 gltX Lactococcus lactis subsp. lactis Il1403 glutamyl-tRNA synthetase NP_268210.1 2140195 R 272623 CDS NP_268211.1 15674036 1115731 complement(2141810..2142340) 1 NC_002662.1 probably amidase, evidenced by COGnitor; hypothetical protein 2142340 yveA 1115731 yveA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268211.1 2141810 R 272623 CDS NP_268212.1 15674037 1115732 complement(2142439..2143362) 1 NC_002662.1 hypothetical protein 2143362 yveB 1115732 yveB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268212.1 2142439 R 272623 CDS NP_268213.1 15674038 1115733 2143591..2144085 1 NC_002662.1 hypothetical protein 2144085 yveC 1115733 yveC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268213.1 2143591 D 272623 CDS NP_268214.1 15674039 1115734 complement(2144177..2144500) 1 NC_002662.1 hypothetical protein 2144500 yveD 1115734 yveD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268214.1 2144177 R 272623 CDS NP_268215.1 15674040 1115735 complement(2144487..2144834) 1 NC_002662.1 hypothetical protein 2144834 yveE 1115735 yveE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268215.1 2144487 R 272623 CDS NP_268216.1 15674041 1115736 complement(2144821..2145183) 1 NC_002662.1 hypothetical protein 2145183 yveF 1115736 yveF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268216.1 2144821 R 272623 CDS NP_268217.1 15674042 1115737 complement(2145303..2145932) 1 NC_002662.1 hypothetical protein 2145932 yveG 1115737 yveG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268217.1 2145303 R 272623 CDS NP_268218.1 15674043 1115738 complement(2145997..2147082) 1 NC_002662.1 hypothetical protein 2147082 yveH 1115738 yveH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268218.1 2145997 R 272623 CDS NP_268219.1 15674044 1115739 complement(2147273..2148220) 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983M 2148220 tra983M 1115739 tra983M Lactococcus lactis subsp. lactis Il1403 transposase of IS983M NP_268219.1 2147273 R 272623 CDS NP_268220.1 15674045 1115740 2148393..2149079 1 NC_002662.1 hypothetical protein 2149079 yveI 1115740 yveI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268220.1 2148393 D 272623 CDS NP_268221.1 15674046 1115741 complement(2149123..2150484) 1 NC_002662.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 2150484 radA 1115741 radA Lactococcus lactis subsp. lactis Il1403 DNA repair protein RadA NP_268221.1 2149123 R 272623 CDS NP_268222.1 15674047 1115742 complement(2150646..2150873) 1 NC_002662.1 hypothetical protein 2150873 yvfA 1115742 yvfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268222.1 2150646 R 272623 CDS NP_268223.1 15674048 1115743 complement(2151172..2151339) 1 NC_002662.1 hypothetical protein 2151339 yvfB 1115743 yvfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268223.1 2151172 R 272623 CDS NP_268224.1 15674049 1115744 complement(2151688..2152068) 1 NC_002662.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 2152068 rplQ 1115744 rplQ Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L17 NP_268224.1 2151688 R 272623 CDS NP_268225.1 15674050 1115745 complement(2152087..2153025) 1 NC_002662.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2153025 rpoA 1115745 rpoA Lactococcus lactis subsp. lactis Il1403 DNA-directed RNA polymerase subunit alpha NP_268225.1 2152087 R 272623 CDS NP_268226.1 15674051 1115746 complement(2153073..2153456) 1 NC_002662.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2153456 rpsK 1115746 rpsK Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S11 NP_268226.1 2153073 R 272623 CDS NP_268227.1 15674052 1115747 complement(2153477..2153842) 1 NC_002662.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2153842 rpsM 1115747 rpsM Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S13 NP_268227.1 2153477 R 272623 CDS NP_268228.1 15674053 1115748 complement(2153860..2153976) 1 NC_002662.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2153976 rpmJ 1115748 rpmJ Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L36 NP_268228.1 2153860 R 272623 CDS NP_268229.1 15674054 1115749 complement(2154030..2154248) 1 NC_002662.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2154248 infA 1115749 infA Lactococcus lactis subsp. lactis Il1403 translation initiation factor IF-1 NP_268229.1 2154030 R 272623 CDS NP_268230.1 15674055 1115750 complement(2154611..2155372) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904H 2155372 tra904H 1115750 tra904H Lactococcus lactis subsp. lactis Il1403 transposase of IS904H NP_268230.1 2154611 R 272623 CDS NP_268231.1 15674056 1115751 complement(2155468..2155758) 1 NC_002662.1 trasposon related functions; hypothetical protein 2155758 yvfD 1115751 yvfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268231.1 2155468 R 272623 CDS NP_268232.1 15674057 1115752 complement(2155831..2156649) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; IS1077F transposase 2156649 tra1077F 1115752 tra1077F Lactococcus lactis subsp. lactis Il1403 IS1077F transposase NP_268232.1 2155831 R 272623 CDS NP_268233.1 15674058 1115753 complement(2156646..2157203) 1 NC_002662.1 transposon related function; hypothetical protein 2157203 yvfC 1115753 yvfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268233.1 2156646 R 272623 CDS NP_268234.1 15674059 1115754 complement(2157280..2157927) 1 NC_002662.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 2157927 adk 1115754 adk Lactococcus lactis subsp. lactis Il1403 adenylate kinase NP_268234.1 2157280 R 272623 CDS NP_268235.1 15674060 1115755 complement(2158067..2159386) 1 NC_002662.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2159386 secY 1115755 secY Lactococcus lactis subsp. lactis Il1403 preprotein translocase subunit SecY NP_268235.1 2158067 R 272623 CDS NP_268236.1 15674061 1115756 complement(2159464..2159907) 1 NC_002662.1 late assembly protein; 50S ribosomal protein L15 2159907 rplO 1115756 rplO Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L15 NP_268236.1 2159464 R 272623 CDS NP_268237.1 15674062 1115757 complement(2160182..2160361) 1 NC_002662.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2160361 rpmD 1115757 rpmD Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L30 NP_268237.1 2160182 R 272623 CDS NP_268238.1 15674063 1115758 complement(2160372..2160878) 1 NC_002662.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2160878 rpsE 1115758 rpsE Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S5 NP_268238.1 2160372 R 272623 CDS NP_268239.1 15674064 1115759 complement(2160897..2161244) 1 NC_002662.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2161244 rplR 1115759 rplR Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L18 NP_268239.1 2160897 R 272623 CDS NP_268240.1 15674065 1115760 complement(2161460..2161996) 1 NC_002662.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2161996 rplF 1115760 rplF Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L6 NP_268240.1 2161460 R 272623 CDS NP_268241.1 15674066 1115761 complement(2162213..2162611) 1 NC_002662.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2162611 rpsH 1115761 rpsH Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S8 NP_268241.1 2162213 R 272623 CDS NP_268242.1 15674067 1115762 complement(2162827..2163411) 1 NC_002662.1 hypothetical protein 2163411 yvgA 1115762 yvgA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268242.1 2162827 R 272623 CDS NP_268243.1 15674068 1115763 complement(2163562..2163747) 1 NC_002662.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 2163747 rpsN 1115763 rpsN Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S14 NP_268243.1 2163562 R 272623 CDS NP_268244.1 15674069 1115764 complement(2163766..2164308) 1 NC_002662.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2164308 rplE 1115764 rplE Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L5 NP_268244.1 2163766 R 272623 CDS NP_268245.1 15674070 1115765 complement(2164328..2164633) 1 NC_002662.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2164633 rplX 1115765 rplX Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L24 NP_268245.1 2164328 R 272623 CDS NP_268246.1 15674071 1115766 complement(2164767..2165135) 1 NC_002662.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 2165135 rplN 1115766 rplN Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L14 NP_268246.1 2164767 R 272623 CDS NP_268247.1 15674072 1115767 complement(2165158..2165418) 1 NC_002662.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2165418 rpsQ 1115767 rpsQ Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S17 NP_268247.1 2165158 R 272623 CDS NP_268248.1 15674073 1115768 complement(2165439..2165648) 1 NC_002662.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2165648 rpmC 1115768 rpmC Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L29 NP_268248.1 2165439 R 272623 CDS NP_268249.1 15674074 1115769 complement(2165648..2166061) 1 NC_002662.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2166061 rplP 1115769 rplP Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L16 NP_268249.1 2165648 R 272623 CDS NP_268250.1 15674075 1115770 complement(2166065..2166718) 1 NC_002662.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2166718 rpsC 1115770 rpsC Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S3 NP_268250.1 2166065 R 272623 CDS NP_268251.1 15674076 1115771 complement(2166731..2167078) 1 NC_002662.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2167078 rplV 1115771 rplV Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L22 NP_268251.1 2166731 R 272623 CDS NP_268252.1 15674077 1115772 complement(2167094..2167372) 1 NC_002662.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 2167372 rpsS 1115772 rpsS Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S19 NP_268252.1 2167094 R 272623 CDS NP_268253.1 15674078 1115773 complement(2167532..2168362) 1 NC_002662.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 2168362 rplB 1115773 rplB Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L2 NP_268253.1 2167532 R 272623 CDS NP_268254.1 15674079 1115774 complement(2168378..2168671) 1 NC_002662.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 2168671 rplW 1115774 rplW Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L23 NP_268254.1 2168378 R 272623 CDS NP_268255.1 15674080 1115775 complement(2168671..2169297) 1 NC_002662.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 2169297 rplD 1115775 rplD Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L4 NP_268255.1 2168671 R 272623 CDS NP_268256.1 15674081 1115776 complement(2169323..2169946) 1 NC_002662.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 2169946 rplC 1115776 rplC Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L3 NP_268256.1 2169323 R 272623 CDS NP_268257.1 15674082 1115777 complement(2169965..2170273) 1 NC_002662.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 2170273 rpsJ 1115777 rpsJ Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S10 NP_268257.1 2169965 R 272623 CDS NP_268258.1 15674083 1115778 2170586..2170954 1 NC_002662.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 2170954 mscL 1115778 mscL Lactococcus lactis subsp. lactis Il1403 large-conductance mechanosensitive channel NP_268258.1 2170586 D 272623 CDS NP_268259.1 15674084 1115779 complement(2170994..2172196) 1 NC_002662.1 similar to MATE efflux family transporter proteins; hypothetical protein 2172196 yvhA 1115779 yvhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268259.1 2170994 R 272623 CDS NP_268260.1 15674085 1115780 complement(2172280..2173770) 1 NC_002662.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 2173770 thrC 1115780 thrC Lactococcus lactis subsp. lactis Il1403 threonine synthase NP_268260.1 2172280 R 272623 CDS NP_268261.1 15674086 1115781 complement(2173872..2174429) 1 NC_002662.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 2174429 nusG 1115781 nusG Lactococcus lactis subsp. lactis Il1403 transcription antitermination protein NusG NP_268261.1 2173872 R 272623 CDS NP_268262.1 15674087 1115782 complement(2174627..2174821) 1 NC_002662.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 2174821 secE 1115782 secE Lactococcus lactis subsp. lactis Il1403 preprotein translocase subunit SecE NP_268262.1 2174627 R 272623 CDS NP_268263.1 15674088 1115783 complement(2174932..2175081) 1 NC_002662.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 2175081 rpmG 1115783 rpmG Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L33 NP_268263.1 2174932 R 272623 CDS NP_268264.1 15674089 1115784 complement(2175122..2176939) 1 NC_002662.1 hypothetical protein 2176939 yvhB 1115784 yvhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268264.1 2175122 R 272623 CDS NP_268265.1 15674090 1115785 complement(2177041..2179272) 1 NC_002662.1 murein sacculus and peptidoglycan; penicillin-binding protein 2a 2179272 pbp2A 1115785 pbp2A Lactococcus lactis subsp. lactis Il1403 penicillin-binding protein 2a NP_268265.1 2177041 R 272623 CDS NP_268266.1 15674091 1115786 complement(2179581..2180216) 1 NC_002662.1 hypothetical protein 2180216 yviA 1115786 yviA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268266.1 2179581 R 272623 CDS NP_268267.1 15674092 1115787 complement(2180233..2180664) 1 NC_002662.1 hypothetical protein 2180664 yviB 1115787 yviB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268267.1 2180233 R 272623 CDS NP_268268.1 15674093 1115788 complement(2180778..2181155) 1 NC_002662.1 energy metabolism, electron transport; FMN-binding protein 2181155 yviC 1115788 yviC Lactococcus lactis subsp. lactis Il1403 FMN-binding protein NP_268268.1 2180778 R 272623 CDS NP_268269.1 15674094 1115789 2181360..2182226 1 NC_002662.1 pseudouridine synthase 2182226 rluA 1115789 rluA Lactococcus lactis subsp. lactis Il1403 pseudouridine synthase NP_268269.1 2181360 D 272623 CDS NP_268270.1 15674095 1115790 complement(2182265..2183074) 1 NC_002662.1 transort and binding protein, cations; zinc ABC transporter permease 2183074 zitP 1115790 zitP Lactococcus lactis subsp. lactis Il1403 zinc ABC transporter permease NP_268270.1 2182265 R 272623 CDS NP_268271.1 15674096 1115791 complement(2183067..2183804) 1 NC_002662.1 transort and binding protein, cations; zinc ABC transporter ATP binding protein 2183804 zitQ 1115791 zitQ Lactococcus lactis subsp. lactis Il1403 zinc ABC transporter ATP binding protein NP_268271.1 2183067 R 272623 CDS NP_268272.1 15674097 1115792 complement(2183981..2184823) 1 NC_002662.1 transort and binding protein, cations; zinc ABC transporter substrate binding protein 2184823 zitS 1115792 zitS Lactococcus lactis subsp. lactis Il1403 zinc ABC transporter substrate binding protein NP_268272.1 2183981 R 272623 CDS NP_268273.1 15674098 1115793 complement(2184820..2185257) 1 NC_002662.1 MarR-family regulators; similar to AdcR repressor of adc locus, affecting competence in Streptococcus pneumoniae; zinc transport transcription regulator 2185257 zitR 1115793 zitR Lactococcus lactis subsp. lactis Il1403 zinc transport transcription regulator NP_268273.1 2184820 R 272623 CDS NP_268274.1 15674099 1115794 complement(2185338..2185622) 1 NC_002662.1 hypothetical protein 2185622 yviH 1115794 yviH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268274.1 2185338 R 272623 CDS NP_268275.1 15674100 1115795 complement(2185661..2186047) 1 NC_002662.1 hypothetical protein 2186047 yviI 1115795 yviI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268275.1 2185661 R 272623 CDS NP_268276.1 15674101 1115796 complement(2186070..2186366) 1 NC_002662.1 hypothetical protein 2186366 yviJ 1115796 yviJ Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268276.1 2186070 R 272623 CDS NP_268277.1 15674102 1115797 complement(2186338..2186769) 1 NC_002662.1 competence protein; transformation; required for the assembly of the competence membrane machinery; protein ComGD 2186769 comGD 1115797 comGD Lactococcus lactis subsp. lactis Il1403 protein ComGD NP_268277.1 2186338 R 272623 CDS NP_268278.1 15674103 1115798 complement(2186729..2187112) 1 NC_002662.1 competence protein; transformation; required for the assembly of the competence membrane machinery; protein ComGC 2187112 comGC 1115798 comGC Lactococcus lactis subsp. lactis Il1403 protein ComGC NP_268278.1 2186729 R 272623 CDS NP_268279.1 15674104 1115799 complement(2187126..2188199) 1 NC_002662.1 competence protein; transformation; required for the assembly of the competence membrane machinery; PULE/OUTE/EXEE/XPSE/XCPR family; protein ComGB 2188199 comGB 1115799 comGB Lactococcus lactis subsp. lactis Il1403 protein ComGB NP_268279.1 2187126 R 272623 CDS NP_268280.1 15674105 1115800 complement(2188093..2189031) 1 NC_002662.1 competence protein; transformation required for the assembly of the competence membrane machinery; PULE/OUTE/EXEE/XPSE/XCPR family; protein ComGA 2189031 comGA 1115800 comGA Lactococcus lactis subsp. lactis Il1403 protein ComGA NP_268280.1 2188093 R 272623 CDS NP_268281.1 15674106 1115801 complement(2189151..2194127) 1 NC_002662.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 2194127 polC 1115801 polC Lactococcus lactis subsp. lactis Il1403 DNA polymerase III PolC NP_268281.1 2189151 R 272623 CDS NP_268282.1 15674107 1115802 complement(2194240..2194776) 1 NC_002662.1 hypothetical protein 2194776 yvjA 1115802 yvjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268282.1 2194240 R 272623 CDS NP_268283.1 15674108 1115803 complement(2194782..2196113) 1 NC_002662.1 aerobic energy metabolism; NADH oxidase 2196113 noxD 1115803 noxD Lactococcus lactis subsp. lactis Il1403 NADH oxidase NP_268283.1 2194782 R 272623 CDS NP_268284.1 15674109 1115804 complement(2196129..2197979) 1 NC_002662.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2197979 proS 1115804 proS Lactococcus lactis subsp. lactis Il1403 prolyl-tRNA synthetase NP_268284.1 2196129 R 272623 CDS NP_268285.1 15674110 1115805 complement(2198049..2199335) 1 NC_002662.1 hypothetical protein 2199335 yvjB 1115805 yvjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268285.1 2198049 R 272623 CDS NP_268286.1 15674111 1115806 complement(2199354..2200157) 1 NC_002662.1 membranes, lipoproteins, and porins; integral membrance protein; phosphatidate cytidylyltransferase 2200157 cdsA 1115806 cdsA Lactococcus lactis subsp. lactis Il1403 phosphatidate cytidylyltransferase NP_268286.1 2199354 R 272623 CDS NP_268287.1 15674112 1115807 complement(2200157..2200891) 1 NC_002662.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 2200891 uppS 1115807 uppS Lactococcus lactis subsp. lactis Il1403 UDP pyrophosphate synthase NP_268287.1 2200157 R 272623 CDS NP_268288.1 15674113 1115808 complement(2201263..2201595) 1 NC_002662.1 hypothetical protein 2201595 ywaB 1115808 ywaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268288.1 2201263 R 272623 CDS NP_268291.2 30024073 1115811 complement(2202406..2202885) 1 NC_002662.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2202885 ywaE 1115811 ywaE Lactococcus lactis subsp. lactis Il1403 rRNA large subunit methyltransferase NP_268291.2 2202406 R 272623 CDS NP_268292.1 15674117 1115812 complement(2202924..2203871) 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983N 2203871 tra983N 1115812 tra983N Lactococcus lactis subsp. lactis Il1403 transposase of IS983N NP_268292.1 2202924 R 272623 CDS NP_268293.1 15674118 1115813 2204341..2205567 1 NC_002662.1 evidence experimental PMID:10712686; degradation of proteins, peptides, and glycopeptides. this protease is responsible for degradation of secreted hybrid proteins; exported serine protease 2205567 htrA 1115813 htrA Lactococcus lactis subsp. lactis Il1403 exported serine protease NP_268293.1 2204341 D 272623 CDS NP_268294.1 15674119 1115814 2205693..2206691 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; similar to CpoA of Streptococcus pneumoniae, supposed to be involved in lipopolysaccharide core biosynthesis; glycosyltransferase 2206691 ywaF 1115814 ywaF Lactococcus lactis subsp. lactis Il1403 glycosyltransferase NP_268294.1 2205693 D 272623 CDS NP_268295.1 15674120 1115815 2206817..2208157 1 NC_002662.1 surface polysaccharides, lipopolysaccharides and antigens; lipopolysaccharide biosynthesis protein 2208157 ywaG 1115815 ywaG Lactococcus lactis subsp. lactis Il1403 lipopolysaccharide biosynthesis protein NP_268295.1 2206817 D 272623 CDS NP_268296.1 15674121 1115816 2208265..2208489 1 NC_002662.1 hypothetical protein 2208489 ywaH 1115816 ywaH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268296.1 2208265 D 272623 CDS NP_268297.1 15674122 1115817 2208631..2209635 1 NC_002662.1 hypothetical protein 2209635 ywaI 1115817 ywaI Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268297.1 2208631 D 272623 CDS NP_268298.1 15674123 1115818 complement(2209676..2210428) 1 NC_002662.1 hypothetical protein 2210428 ywbA 1115818 ywbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268298.1 2209676 R 272623 CDS NP_268299.1 15674124 1115819 complement(2210775..2213408) 1 NC_002662.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 2213408 polA 1115819 polA Lactococcus lactis subsp. lactis Il1403 DNA polymerase I NP_268299.1 2210775 R 272623 CDS NP_268300.1 15674125 1115820 2213646..2214455 1 NC_002662.1 hypothetical protein 2214455 ywbB 1115820 ywbB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268300.1 2213646 D 272623 CDS NP_268301.1 15674126 1115821 2214455..2214865 1 NC_002662.1 LacI-family regulators; probably the N-terminal part of rliD, interrupted by transposon insertion; transcriptional regulator 2214865 rliDA 1115821 rliDA Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268301.1 2214455 D 272623 CDS NP_268302.1 15674127 1115822 complement(2214945..2215706) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase; transposase of IS904I 2215706 tra904I 1115822 tra904I Lactococcus lactis subsp. lactis Il1403 transposase of IS904I NP_268302.1 2214945 R 272623 CDS NP_268303.1 15674128 1115823 complement(2215802..2216092) 1 NC_002662.1 transposon related function; hypothetical protein 2216092 yvjF 1115823 yvjF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268303.1 2215802 R 272623 CDS NP_268304.1 15674129 1115824 complement(2216165..2216983) 1 NC_002662.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase; IS1077G transposase 2216983 tra1077G 1115824 tra1077G Lactococcus lactis subsp. lactis Il1403 IS1077G transposase NP_268304.1 2216165 R 272623 CDS NP_268305.1 15674130 1115825 complement(2216980..2217537) 1 NC_002662.1 transposon related function; hypothetical protein 2217537 ywbC 1115825 ywbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268305.1 2216980 R 272623 CDS NP_268306.1 15674131 1115826 2217579..2218112 1 NC_002662.1 LacI-family regulators; probably the C-terminal part of rliD, interrupted by transposon insertion; transcriptional regulator 2218112 rliDB 1115826 rliDB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268306.1 2217579 D 272623 CDS NP_268307.1 15674132 1115827 complement(2223528..2223956) 1 NC_002662.1 competence regulator; transformation; similar to ComX1 from Streptococcus pneumoniae. Probably a sigma factor, involved in regulation of competence; protein ComX 2223956 comX 1115827 comX Lactococcus lactis subsp. lactis Il1403 protein ComX NP_268307.1 2223528 R 272623 CDS NP_268308.1 15674133 1115828 complement(2224277..2226007) 1 NC_002662.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 2226007 ezrA 1115828 ezrA Lactococcus lactis subsp. lactis Il1403 septation ring formation regulator EzrA NP_268308.1 2224277 R 272623 CDS NP_268309.1 15674134 1115829 complement(2226193..2227221) 1 NC_002662.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2227221 tsf 1115829 tsf Lactococcus lactis subsp. lactis Il1403 elongation factor Ts NP_268309.1 2226193 R 272623 CDS NP_268310.1 15674135 1115830 complement(2227343..2228110) 1 NC_002662.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2228110 rpsB 1115830 rpsB Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S2 NP_268310.1 2227343 R 272623 CDS NP_268311.1 15674136 1115831 2228469..2229494 1 NC_002662.1 similar to YkbG of Bacillus subtilis; hypothetical protein 2229494 ywcC 1115831 ywcC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268311.1 2228469 D 272623 CDS NP_268312.1 15674137 1115832 2229727..2232438 1 NC_002662.1 evidence experimental PMID:9620952; energy metabolism; fermentation; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 2232438 adhE 1115832 adhE Lactococcus lactis subsp. lactis Il1403 bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_268312.1 2229727 D 272623 CDS NP_268313.1 15674138 1115833 complement(2232776..2233273) 1 NC_002662.1 hypothetical protein 2233273 ywdA 1115833 ywdA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268313.1 2232776 R 272623 CDS NP_268314.1 15674139 1115834 complement(2233260..2233469) 1 NC_002662.1 hypothetical protein 2233469 ywdB 1115834 ywdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268314.1 2233260 R 272623 CDS NP_268315.1 15674140 1115835 complement(2233466..2234293) 1 NC_002662.1 hypothetical protein 2234293 ywdC 1115835 ywdC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268315.1 2233466 R 272623 CDS NP_268316.1 15674141 1115836 complement(2234286..2236409) 1 NC_002662.1 hypothetical protein 2236409 ywdD 1115836 ywdD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268316.1 2234286 R 272623 CDS NP_268317.1 15674142 1115837 complement(2236512..2237369) 1 NC_002662.1 general regulatory function; transcriptional regulator 2237369 ywdE 1115837 ywdE Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268317.1 2236512 R 272623 CDS NP_268318.1 15674143 1115838 complement(2237490..2238518) 1 NC_002662.1 hypothetical protein 2238518 ywdF 1115838 ywdF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268318.1 2237490 R 272623 CDS NP_268319.1 15674144 1115839 complement(2238505..2239002) 1 NC_002662.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2239002 coaD 1115839 coaD Lactococcus lactis subsp. lactis Il1403 phosphopantetheine adenylyltransferase NP_268319.1 2238505 R 272623 CDS NP_268320.1 15674145 1115840 complement(2239050..2239616) 1 NC_002662.1 N6-adenine-specific methylase, evidenced by COGnitor; similar to type II DNA modification methyltransferase; hypothetical protein 2239616 ywdG 1115840 ywdG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268320.1 2239050 R 272623 CDS NP_268321.1 15674146 1115841 complement(2239760..2240980) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to the integral membrane protein LmrP from Lactococcus lactis; membrane protein 2240980 yweA 1115841 yweA Lactococcus lactis subsp. lactis Il1403 membrane protein NP_268321.1 2239760 R 272623 CDS NP_268322.1 15674147 1115842 complement(2241064..2242290) 1 NC_002662.1 integral membrane protein; transport and binding protein; multidrug resistance; there is no connection with the lmrA gene; LmrP 2242290 lmrP 1115842 lmrP Lactococcus lactis subsp. lactis Il1403 LmrP NP_268322.1 2241064 R 272623 CDS NP_268323.1 15674148 1115843 2242478..2242972 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; RNA polymerase ECF sigma factor 2242972 sigX 1115843 sigX Lactococcus lactis subsp. lactis Il1403 RNA polymerase ECF sigma factor NP_268323.1 2242478 D 272623 CDS NP_268324.1 15674149 1115844 2242996..2244102 1 NC_002662.1 hypothetical protein 2244102 yweB 1115844 yweB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268324.1 2242996 D 272623 CDS NP_268325.1 15674150 1115845 complement(2244198..2245544) 1 NC_002662.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 2245544 pgi 1115845 pgi Lactococcus lactis subsp. lactis Il1403 glucose-6-phosphate isomerase NP_268325.1 2244198 R 272623 CDS NP_268326.1 15674151 1115846 2245888..2246394 1 NC_002662.1 hypothetical protein 2246394 yweC 1115846 yweC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268326.1 2245888 D 272623 CDS NP_268327.1 15674152 1115847 complement(2246428..2247273) 1 NC_002662.1 hypothetical protein 2247273 yweD 1115847 yweD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268327.1 2246428 R 272623 CDS NP_268328.1 15674153 1115848 2247500..2247778 1 NC_002662.1 hypothetical protein 2247778 yweE 1115848 yweE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268328.1 2247500 D 272623 CDS NP_268329.1 15674154 1115849 2247891..2248223 1 NC_002662.1 hypothetical protein 2248223 yweF 1115849 yweF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268329.1 2247891 D 272623 CDS NP_268330.1 15674155 1115850 complement(2248267..2250909) 1 NC_002662.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 2250909 valS 1115850 valS Lactococcus lactis subsp. lactis Il1403 valyl-tRNA synthetase NP_268330.1 2248267 R 272623 CDS NP_268331.1 15674156 1115851 complement(2251165..2251821) 1 NC_002662.1 hypothetical protein 2251821 ywfA 1115851 ywfA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268331.1 2251165 R 272623 CDS NP_268332.1 15674157 1115852 complement(2252098..2252346) 1 NC_002662.1 hypothetical protein 2252346 ywfB 1115852 ywfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268332.1 2252098 R 272623 CDS NP_268333.1 15674158 1115853 complement(2252385..2252729) 1 NC_002662.1 hypothetical protein 2252729 ywfC 1115853 ywfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268333.1 2252385 R 272623 CDS NP_268334.1 15674159 1115854 complement(2252730..2253239) 1 NC_002662.1 hypothetical protein 2253239 ywfD 1115854 ywfD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268334.1 2252730 R 272623 CDS NP_268335.1 15674160 1115855 complement(2253394..2254101) 1 NC_002662.1 hypothetical protein 2254101 ywfE 1115855 ywfE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268335.1 2253394 R 272623 CDS NP_268336.1 15674161 1115856 complement(2254433..2255974) 1 NC_002662.1 hypothetical protein 2255974 ywfF 1115856 ywfF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268336.1 2254433 R 272623 CDS NP_268337.1 15674162 1115857 complement(2256203..2258983) 1 NC_002662.1 hypothetical protein 2258983 ywfG 1115857 ywfG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268337.1 2256203 R 272623 CDS NP_268338.1 15674163 1115858 complement(2259052..2259525) 1 NC_002662.1 hypothetical protein 2259525 ywfH 1115858 ywfH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268338.1 2259052 R 272623 CDS NP_268339.1 15674164 1115859 2259811..2260623 1 NC_002662.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2260623 recX 1115859 recX Lactococcus lactis subsp. lactis Il1403 recombination regulator RecX NP_268339.1 2259811 D 272623 CDS NP_268340.1 15674165 1115861 complement(2267576..2268523) 1 NC_002662.1 transposon related function; belongs to the IS30 family of transposase; transposase of IS983O 2268523 tra983O 1115861 tra983O Lactococcus lactis subsp. lactis Il1403 transposase of IS983O NP_268340.1 2267576 R 272623 CDS NP_268341.1 15674166 1115862 complement(2268572..2270131) 1 NC_002662.1 energy metabolism, sugars; gluconate kinase 2270131 gntK 1115862 gntK Lactococcus lactis subsp. lactis Il1403 gluconate kinase NP_268341.1 2268572 R 272623 CDS NP_268342.1 15674167 1115863 complement(2270252..2271160) 1 NC_002662.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 2271160 gntZ 1115863 gntZ Lactococcus lactis subsp. lactis Il1403 6-phosphogluconate dehydrogenase NP_268342.1 2270252 R 272623 CDS NP_268343.1 15674168 1115864 2271521..2272369 1 NC_002662.1 RpiR family of transcription regulators; probably involved in gnt operon regulation; transcriptional regulator 2272369 gntR 1115864 gntR Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268343.1 2271521 D 272623 CDS NP_268344.1 15674169 1115865 2272407..2272715 1 NC_002662.1 hypothetical protein 2272715 ywhA 1115865 ywhA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268344.1 2272407 D 272623 CDS NP_268345.1 15674170 1115866 complement(2272789..2273562) 1 NC_002662.1 probably a phosphohydrolase, evidenced by COGnitor; hypothetical protein 2273562 ywhB 1115866 ywhB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268345.1 2272789 R 272623 CDS NP_268346.1 15674171 1115867 complement(2273762..2274007) 1 NC_002662.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 2274007 rpsR 1115867 rpsR Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S18 NP_268346.1 2273762 R 272623 CDS NP_268347.1 15674172 1115868 complement(2274181..2274681) 1 NC_002662.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 2274681 ssbB 1115868 ssbB Lactococcus lactis subsp. lactis Il1403 single-stranded DNA-binding protein NP_268347.1 2274181 R 272623 CDS NP_268348.1 15674173 1115869 complement(2274711..2275004) 1 NC_002662.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 2275004 rpsF 1115869 rpsF Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S6 NP_268348.1 2274711 R 272623 CDS NP_268349.1 15674174 1115870 complement(2275196..2276050) 1 NC_002662.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 2276050 uppP 1115870 uppP Lactococcus lactis subsp. lactis Il1403 UDP pyrophosphate phosphatase NP_268349.1 2275196 R 272623 CDS NP_268350.1 15674175 1115871 2276518..2278038 1 NC_002662.1 transport and binding protein; amino acids, peptides and amines; there is another lysine specific permease LysQ; lysine specific permease 2278038 lysP 1115871 lysP Lactococcus lactis subsp. lactis Il1403 lysine specific permease NP_268350.1 2276518 D 272623 CDS NP_268351.1 15674176 1115872 complement(2278073..2279731) 1 NC_002662.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 2279731 dnaH 1115872 dnaH Lactococcus lactis subsp. lactis Il1403 DNA polymerase III subunits gamma and tau NP_268351.1 2278073 R 272623 CDS NP_268352.1 15674177 1115873 complement(2279780..2280421) 1 NC_002662.1 hypothetical protein 2280421 ywiA 1115873 ywiA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268352.1 2279780 R 272623 CDS NP_268353.1 15674178 1115874 complement(2280453..2280941) 1 NC_002662.1 hypothetical protein 2280941 ywiB 1115874 ywiB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268353.1 2280453 R 272623 CDS NP_268354.1 15674179 1115875 2281025..2281297 1 NC_002662.1 similar to N-terminal part of chorismate mutases from several species; hypothetical protein 2281297 ywiC 1115875 ywiC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268354.1 2281025 D 272623 CDS NP_268355.1 15674180 1115876 complement(2281386..2281832) 1 NC_002662.1 hypothetical protein 2281832 ywiD 1115876 ywiD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268355.1 2281386 R 272623 CDS NP_268356.1 15674181 1115877 2282050..2282250 1 NC_002662.1 hypothetical protein 2282250 ywiE 1115877 ywiE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268356.1 2282050 D 272623 CDS NP_268357.1 15674182 1115878 complement(2282309..2283649) 1 NC_002662.1 glutamate family; glutamine synthetase 2283649 glnA 1115878 glnA Lactococcus lactis subsp. lactis Il1403 glutamine synthetase NP_268357.1 2282309 R 272623 CDS NP_268358.2 30024074 1115879 complement(2283711..2284076) 1 NC_002662.1 MerR family of transcription regulators; glutamine synthetase 2284076 glnR 1115879 glnR Lactococcus lactis subsp. lactis Il1403 glutamine synthetase NP_268358.2 2283711 R 272623 CDS NP_268359.1 15674184 1115880 complement(2284177..2284614) 1 NC_002662.1 protein modification; tyrosine phosphatase 2284614 ptpL 1115880 ptpL Lactococcus lactis subsp. lactis Il1403 tyrosine phosphatase NP_268359.1 2284177 R 272623 CDS NP_268360.1 15674185 1115881 complement(2285027..2285644) 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 2285644 ywiG 1115881 ywiG Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_268360.1 2285027 R 272623 CDS NP_268361.1 15674186 1115882 complement(2285641..2286825) 1 NC_002662.1 transport and binding protein; ABC transporter permease 2286825 ywiH 1115882 ywiH Lactococcus lactis subsp. lactis Il1403 ABC transporter permease NP_268361.1 2285641 R 272623 CDS NP_268362.1 15674187 1115883 complement(2287402..2288286) 1 NC_002662.1 similar to a positive regulator GadR from Lactococcus lactis; transcriptional regulator 2288286 ywiI 1115883 ywiI Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268362.1 2287402 R 272623 CDS NP_268363.1 15674188 1115884 complement(2288423..2289397) 1 NC_002662.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2289397 ruvB 1115884 ruvB Lactococcus lactis subsp. lactis Il1403 Holliday junction DNA helicase RuvB NP_268363.1 2288423 R 272623 CDS NP_268364.1 15674189 1115885 complement(2289550..2290143) 1 NC_002662.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2290143 ruvA 1115885 ruvA Lactococcus lactis subsp. lactis Il1403 Holliday junction DNA helicase RuvA NP_268364.1 2289550 R 272623 CDS NP_268365.1 15674190 1115886 complement(2290256..2292343) 1 NC_002662.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 2292343 mutL 1115886 mutL Lactococcus lactis subsp. lactis Il1403 DNA mismatch repair protein NP_268365.1 2290256 R 272623 CDS NP_268366.1 15674191 1115887 complement(2292355..2293050) 1 NC_002662.1 hypothetical protein 2293050 ywjA 1115887 ywjA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268366.1 2292355 R 272623 CDS NP_268367.1 15674192 1115888 complement(2293165..2295687) 1 NC_002662.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2295687 hexA 1115888 hexA Lactococcus lactis subsp. lactis Il1403 DNA mismatch repair protein MutS NP_268367.1 2293165 R 272623 CDS NP_268368.1 15674193 1115889 complement(2295881..2296228) 1 NC_002662.1 hypothetical protein 2296228 ywjB 1115889 ywjB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268368.1 2295881 R 272623 CDS NP_268369.1 15674194 1115890 complement(2296386..2296484) 1 NC_002662.1 hypothetical protein 2296484 ywjC 1115890 ywjC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268369.1 2296386 R 272623 CDS NP_268370.1 15674195 1115891 complement(2296597..2296905) 1 NC_002662.1 PBSX(XRE) family of transcription regulators; transcriptional regulator 2296905 ywjD 1115891 ywjD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268370.1 2296597 R 272623 CDS NP_268371.1 15674196 1115892 2297032..2297985 1 NC_002662.1 hypothetical protein 2297985 ywjE 1115892 ywjE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268371.1 2297032 D 272623 CDS NP_268372.1 15674197 1115893 complement(2298168..2299049) 1 NC_002662.1 energy metabolism, amino acids and amines; 3-hydroxyisobutyrate dehydrogenase 2299049 ywjF 1115893 ywjF Lactococcus lactis subsp. lactis Il1403 3-hydroxyisobutyrate dehydrogenase NP_268372.1 2298168 R 272623 CDS NP_268373.1 15674198 1115894 complement(2299091..2299411) 1 NC_002662.1 hypothetical protein 2299411 ywjG 1115894 ywjG Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268373.1 2299091 R 272623 CDS NP_268374.1 15674199 1115895 complement(2299656..2300033) 1 NC_002662.1 hypothetical protein 2300033 ywjH 1115895 ywjH Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268374.1 2299656 R 272623 CDS NP_268375.1 15674200 1115896 complement(2300033..2300884) 1 NC_002662.1 transport and binding protein; permease 2300884 yxaA 1115896 yxaA Lactococcus lactis subsp. lactis Il1403 permease NP_268375.1 2300033 R 272623 CDS NP_268376.1 15674201 1115897 2301070..2301249 1 NC_002662.1 hypothetical protein 2301249 yxaB 1115897 yxaB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268376.1 2301070 D 272623 CDS NP_268377.1 15674202 1115898 2301320..2302831 1 NC_002662.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2302831 zwf 1115898 zwf Lactococcus lactis subsp. lactis Il1403 glucose-6-phosphate 1-dehydrogenase NP_268377.1 2301320 D 272623 CDS NP_268378.1 15674203 1115899 complement(2303023..2303550) 1 NC_002662.1 hypothetical protein 2303550 yxaC 1115899 yxaC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268378.1 2303023 R 272623 CDS NP_268379.1 15674204 1115900 2303692..2305140 1 NC_002662.1 glucosyltransferase-S 2305140 pspA 1115900 pspA Lactococcus lactis subsp. lactis Il1403 glucosyltransferase-S NP_268379.1 2303692 D 272623 CDS NP_268380.1 15674205 1115901 complement(2305195..2306646) 1 NC_002662.1 glucosyltransferase-S 2306646 pspB 1115901 pspB Lactococcus lactis subsp. lactis Il1403 glucosyltransferase-S NP_268380.1 2305195 R 272623 CDS NP_268381.1 15674206 1115902 complement(2307231..2308370) 1 NC_002662.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 2308370 dnaJ 1115902 dnaJ Lactococcus lactis subsp. lactis Il1403 chaperone protein DnaJ NP_268381.1 2307231 R 272623 CDS NP_268382.1 15674207 1115903 complement(2308550..2309227) 1 NC_002662.1 hypothetical protein 2309227 yxaF 1115903 yxaF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268382.1 2308550 R 272623 CDS NP_268383.1 15674208 1115904 complement(2309217..2309939) 1 NC_002662.1 evidence experimental PMID:1907199; murein sacculus and peptidoglycan; provides D-aspartate, which plays a role of cross-bridge during peptidoglycan network formation; aspartate racemase 2309939 racD 1115904 racD Lactococcus lactis subsp. lactis Il1403 aspartate racemase NP_268383.1 2309217 R 272623 CDS NP_268384.1 15674209 1115905 complement(2309971..2311197) 1 NC_002662.1 probably carbamoylphosphate synthase large subunit, evidenced by COGnitor; hypothetical protein 2311197 yxbA 1115905 yxbA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268384.1 2309971 R 272623 CDS NP_268385.1 15674210 1115906 complement(2311209..2313086) 1 NC_002662.1 aspartate family; asparagine synthetase 2313086 asnH 1115906 asnH Lactococcus lactis subsp. lactis Il1403 asparagine synthetase NP_268385.1 2311209 R 272623 CDS NP_268386.1 15674211 1115907 complement(2313209..2314579) 1 NC_002662.1 evidence experimental PMID:2123812; secreted 45 kDa precursor; hypothetical protein 2314579 usp45 1115907 usp45 Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268386.1 2313209 R 272623 CDS NP_268387.1 15674212 1115908 complement(2314683..2315210) 1 NC_002662.1 murein sacculus and peptidoglycan; involved in formation of the shape of the cell; may contribute to regulation of formation of penicillin-binding proteins; cell shape determining protein 2315210 mreD 1115908 mreD Lactococcus lactis subsp. lactis Il1403 cell shape determining protein NP_268387.1 2314683 R 272623 CDS NP_268388.1 15674213 1115909 complement(2315300..2316175) 1 NC_002662.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2316175 mreC 1115909 mreC Lactococcus lactis subsp. lactis Il1403 rod shape-determining protein MreC NP_268388.1 2315300 R 272623 CDS NP_268389.1 15674214 1115910 2316468..2316908 1 NC_002662.1 hypothetical protein 2316908 yxbC 1115910 yxbC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268389.1 2316468 D 272623 CDS NP_268390.1 15674215 1115911 complement(2316936..2317610) 1 NC_002662.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2317610 rpiA 1115911 rpiA Lactococcus lactis subsp. lactis Il1403 ribose-5-phosphate isomerase A NP_268390.1 2316936 R 272623 CDS NP_268391.1 15674216 1115912 complement(2317694..2318380) 1 NC_002662.1 CRP/FNR family of transcription regulators; transcriptional regulator 2318380 rcfB 1115912 rcfB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268391.1 2317694 R 272623 CDS NP_268392.1 15674217 1115913 complement(2318463..2319683) 1 NC_002662.1 transport and binding protein; multidrug resistance; similar to quinolon resistance protein NorA from difference species; transporter 2319683 yxbD 1115913 yxbD Lactococcus lactis subsp. lactis Il1403 transporter NP_268392.1 2318463 R 272623 CDS NP_268393.1 15674218 1115914 complement(2319746..2320183) 1 NC_002662.1 hypothetical protein 2320183 yxbE 1115914 yxbE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268393.1 2319746 R 272623 CDS NP_268394.1 15674219 1115915 complement(2320203..2320406) 1 NC_002662.1 hypothetical protein 2320406 yxbF 1115915 yxbF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268394.1 2320203 R 272623 CDS NP_268395.1 15674220 1115916 complement(2320666..2324976) 1 NC_002662.1 similar to activator of (R)-2-hydroxyglutaryl-CoA dehydratase of Acidaminococcus fermentans; hypothetical protein 2324976 yxcA 1115916 yxcA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268395.1 2320666 R 272623 CDS NP_268396.1 15674221 1115917 2325385..2325999 1 NC_002662.1 belongs to TetR/AcrR family; transcriptional regulator 2325999 yxcB 1115917 yxcB Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268396.1 2325385 D 272623 CDS NP_268397.1 15674222 1115918 complement(2326078..2326899) 1 NC_002662.1 RNA synthesis, modification, and DNA transcription; formation of pseudouridine from uracil-516 in 16S rRNA; family 1 of pseudouridine synthases and rluC; ribosomal small subunit pseudouridine synthase A 2326899 rsuA 1115918 rsuA Lactococcus lactis subsp. lactis Il1403 ribosomal small subunit pseudouridine synthase A NP_268397.1 2326078 R 272623 CDS NP_268398.1 15674223 1115919 complement(2326902..2327624) 1 NC_002662.1 similar to P50 adhesin of Mycoplasma hominisadhesins; probably a surface protein; hypothetical protein 2327624 yxcD 1115919 yxcD Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268398.1 2326902 R 272623 CDS NP_268399.1 15674224 1115920 2327749..2329116 1 NC_002662.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 2329116 trmE 1115920 trmE Lactococcus lactis subsp. lactis Il1403 tRNA modification GTPase TrmE NP_268399.1 2327749 D 272623 CDS NP_268400.1 15674225 1115921 complement(2329167..2329913) 1 NC_002662.1 hypothetical protein 2329913 yxcE 1115921 yxcE Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268400.1 2329167 R 272623 CDS NP_268401.1 15674226 1115922 complement(2329913..2331913) 1 NC_002662.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2331913 recG 1115922 recG Lactococcus lactis subsp. lactis Il1403 ATP-dependent DNA helicase RecG NP_268401.1 2329913 R 272623 CDS NP_268402.1 15674227 1115923 complement(2332051..2332395) 1 NC_002662.1 transport and binding protein, anions; alkylphosphonate uptake protein 2332395 phnA 1115923 phnA Lactococcus lactis subsp. lactis Il1403 alkylphosphonate uptake protein NP_268402.1 2332051 R 272623 CDS NP_268403.1 15674228 1115924 complement(2332466..2333476) 1 NC_002662.1 glycolysis; glyceraldehyde 3-phosphate dehydrogenase 2333476 gapB 1115924 gapB Lactococcus lactis subsp. lactis Il1403 glyceraldehyde 3-phosphate dehydrogenase NP_268403.1 2332466 R 272623 CDS NP_268404.1 15674229 1115925 complement(2333756..2334277) 1 NC_002662.1 hypothetical protein 2334277 yxdB 1115925 yxdB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268404.1 2333756 R 272623 CDS NP_268405.1 15674230 1115926 2334405..2337098 1 NC_002662.1 transort and binding protein; cations; cation-transporting ATPase 2337098 yxdC 1115926 yxdC Lactococcus lactis subsp. lactis Il1403 cation-transporting ATPase NP_268405.1 2334405 D 272623 CDS NP_268406.1 15674231 1115927 complement(2337140..2337613) 1 NC_002662.1 general regulatory function; transcriptional regulator 2337613 yxdD 1115927 yxdD Lactococcus lactis subsp. lactis Il1403 transcriptional regulator NP_268406.1 2337140 R 272623 CDS NP_268407.1 15674232 1115928 2337792..2338811 1 NC_002662.1 aerobic energy metabolism; similar to different oxidoreductases; oxidoreductase 2338811 yxdE 1115928 yxdE Lactococcus lactis subsp. lactis Il1403 oxidoreductase NP_268407.1 2337792 D 272623 CDS NP_268408.1 15674233 1115929 2339285..2339818 1 NC_002662.1 hypothetical protein 2339818 yxdF 1115929 yxdF Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268408.1 2339285 D 272623 CDS NP_268409.1 15674234 1115930 2339842..2340297 1 NC_002662.1 transport and binding protein; transporter 2340297 yxdG 1115930 yxdG Lactococcus lactis subsp. lactis Il1403 transporter NP_268409.1 2339842 D 272623 CDS NP_268410.1 15674235 1115931 complement(2346315..2346707) 1 NC_002662.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 2346707 rpsI 1115931 rpsI Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S9 NP_268410.1 2346315 R 272623 CDS NP_268411.1 15674236 1115932 complement(2346727..2347173) 1 NC_002662.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 2347173 rplM 1115932 rplM Lactococcus lactis subsp. lactis Il1403 50S ribosomal protein L13 NP_268411.1 2346727 R 272623 CDS NP_268412.1 15674237 1115933 2347540..2348613 1 NC_002662.1 hypothetical protein 2348613 yxeA 1115933 yxeA Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268412.1 2347540 D 272623 CDS NP_268413.1 15674238 1115934 2348622..2349293 1 NC_002662.1 transport and binding protein; ABC transporter ATP-binding protein 2349293 yxeB 1115934 yxeB Lactococcus lactis subsp. lactis Il1403 ABC transporter ATP-binding protein NP_268413.1 2348622 D 272623 CDS NP_268414.1 15674239 1115935 2349438..2350316 1 NC_002662.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 2350316 rnhA 1115935 rnhA Lactococcus lactis subsp. lactis Il1403 ribonuclease HIII NP_268414.1 2349438 D 272623 CDS NP_268415.1 15674240 1115936 2350328..2350954 1 NC_002662.1 protein and peptide secretion; signal peptidase I 2350954 sipL 1115936 sipL Lactococcus lactis subsp. lactis Il1403 signal peptidase I NP_268415.1 2350328 D 272623 CDS NP_268416.1 15674241 1115937 complement(2351004..2351819) 1 NC_002662.1 general regulatory function; pur operon repressor 2351819 purR 1115937 purR Lactococcus lactis subsp. lactis Il1403 pur operon repressor NP_268416.1 2351004 R 272623 CDS NP_268417.1 15674242 1115938 complement(2352170..2354299) 1 NC_002662.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 2354299 fusA 1115938 fusA Lactococcus lactis subsp. lactis Il1403 elongation factor G NP_268417.1 2352170 R 272623 CDS NP_268418.1 15674243 1115939 complement(2354564..2355031) 1 NC_002662.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 2355031 rpsG 1115939 rpsG Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S7 NP_268418.1 2354564 R 272623 CDS NP_268419.1 15674244 1115940 complement(2355050..2355463) 1 NC_002662.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 2355463 rpsL 1115940 rpsL Lactococcus lactis subsp. lactis Il1403 30S ribosomal protein S12 NP_268419.1 2355050 R 272623 CDS NP_268420.1 15674245 1115941 2355791..2357098 1 NC_002662.1 murein sacculus and peptidoglycan; final stages in peptidoglycan synthesis; peptidase family S11, also know as D-alanyl-D-alanine carboxypeptidase 1 family; D-alanyl-D-alanine carboxypeptidase 2357098 dacA 1115941 dacA Lactococcus lactis subsp. lactis Il1403 D-alanyl-D-alanine carboxypeptidase NP_268420.1 2355791 D 272623 CDS NP_268421.1 15674246 1115942 complement(2357172..2358059) 1 NC_002662.1 transport and binding protein; similar to several membrane proteins; transporter 2358059 yxfA 1115942 yxfA Lactococcus lactis subsp. lactis Il1403 transporter NP_268421.1 2357172 R 272623 CDS NP_268422.1 15674247 1115943 complement(2358185..2358775) 1 NC_002662.1 similar to YtqB of Bacillus subtilis; probably SAM-dependent methyltransferase, evidence by COGnitor; hypothetical protein 2358775 yxfB 1115943 yxfB Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268422.1 2358185 R 272623 CDS NP_268423.1 15674248 1115944 complement(2358906..2359847) 1 NC_002662.1 hypothetical protein 2359847 yxfC 1115944 yxfC Lactococcus lactis subsp. lactis Il1403 hypothetical protein NP_268423.1 2358906 R 272623 CDS