-- dump date 20140619_125613 -- class Genbank::CDS -- table cds_note -- id note NP_266157.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_266158.1 binds the polymerase to DNA and acts as a sliding clamp NP_266159.1 evidence experimental PMID:9435243; exonuclease is specifically blocked by the lactococcal Chi site (5'-GCGCGTG-3'); RexAB-mediated recombination stimulated approximately 27-fold by lactococcal Chi NP_266161.1 belongs to the PBSX(XRE) family of transcription regulators NP_266162.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_266163.1 belongs to the PBSX(XRE) family of transcription regulators NP_266166.1 transport and binding protein NP_266168.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_266172.1 similar to cell division protein DivIC of Bacillus subtilis; in Bacillus subtilis required for activation of genes expressed under the control of the sigma E and sigma F NP_266173.1 similar to Bacillus subtilis hypothetical 14.2 kDa protein NP_266175.1 cell cycle protein NP_266176.1 evidence experimental PMID:1465108 NP_266177.1 cell division protein; evidence experimental PMID:8000529 NP_266178.1 LysR-family regulator; probable regulator of mtl operon NP_266179.1 transport and binding protein; PTS system NP_266180.1 energy metabolism NP_266181.1 similar to bacterial sigma factors NP_266182.1 similar to a hypothetical protein of Lactococcus lactis subsp. cremoris S114 Y11901 NP_266183.1 prophage ps1 protein 03; essential for phage DNA maturation and packaging NP_266185.1 prophage ps1 protein 05; similar to primase of Streptococcus thermophilus bacteriophage DT1 NP_266186.1 similar to Orf1 of Streptococcus thermophilus bacteriophage SFi18 NP_266191.1 PBSX(XRE) family of transcription regulators NP_266192.1 similar to a DNA polymerase of Neurospora crassa mitochondrion plasmid maranhar NP_266194.1 similar to Rha protein of Escherichia coli phage phi-80 NP_266195.1 transcription regulator; similar to Rad protein of Lactobacillus bacteriophage phi adh NP_266202.1 similar to lactococcin A immunity protein NP_266203.1 prophage ps1 protein 23 NP_266204.1 paralogous to yfhA NP_266206.1 transport and binding protein, anions; similar to several sulfate transporters NP_266208.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266209.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266210.1 transposon related function NP_266211.1 similar to hypothetical protein YvdB from Bacillus subtilis NP_266213.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci NP_266214.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA NP_266215.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_266216.1 pyruvate dehydrogenase NP_266217.1 pyruvate dehydrogenase NP_266218.1 pyruvate dehydrogenase NP_266220.1 similar to glycerophosphoryl diester phosphodiesterases NP_266221.1 exists in AT rich gram positives and in archae NP_266222.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_266223.1 adaptations and atypical conditions; similar to osmotically inducible protein OsmC of Escherichia coli NP_266224.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_266226.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_266228.1 transport and binding protein; contains two ATP binding domains NP_266230.1 aerobic energy metabolism NP_266236.1 evidence experimental PMID:8633867; transport and binding protein; multidrug resistance; in the strain diacetylactis WM4 involved in secretion of lactococcin A; HlyD family of secretion proteins NP_266237.1 transport and binding protein NP_266240.1 similar to LcnD of Lactococcus lactis NP_266241.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653 NP_266242.1 transport and binding protein; similar to several membrane proteins NP_266243.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_266244.1 transposon related function; orf1 of IS981 NP_266245.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653 NP_266246.1 transposon related function; orf1 of IS981 NP_266249.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_266250.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_266251.1 transort and binding protein, cations; cation transport ATPase family (E1-E2 ATPase) NP_266254.1 DNA replication, restriction, modification, recombination, and repair NP_266256.1 transport and binding protein; contains two ATP binding domains NP_266259.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_266260.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_266262.1 general regulatory function NP_266263.1 glycosyltransferase family 2 NP_266264.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_266267.1 transport and binding protein; amino acids, peptides and amines; similar to many cationic amino acid transporters NP_266269.1 MarR-family regulator NP_266270.1 converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP; probable NAD(P)H dehydrogenase NP_266271.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_266272.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive NP_266273.1 transport and binding protein; PTS system NP_266274.1 transport and binding protein; PTS system; PTS system enzyme I NP_266278.1 chaperones NP_266279.1 multidrug resistance NP_266280.2 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming NP_266281.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_266282.1 transport and binding protein; multidrug resistance; similar to PmrA of Streptococcus pneumoniae NP_266283.1 similar to Escherichia coli tetracycline repressor protein NP_266284.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_266285.1 similar to SpoIIIJ protein of Bacillus subtilis; attached to membrane by a lipid anchor NP_266286.1 similar to spoIIIJ-associated protein Jag protein from differenr species NP_266287.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_266288.1 belongs to the PBSX(XRE) family of transcription regulators NP_266290.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653 NP_266291.1 similar to OrfX from AbiG region of plasmid pCI750 from Lactococcus lactis subsp. cremoris UC653 NP_266292.1 transposon related function NP_266293.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266294.1 transposon related function NP_266295.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266296.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266297.1 transposon related function NP_266299.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_266300.1 similar to YrzB of Bacillus subtilis NP_266302.1 aerobic energy metabolism; short-chain dehydrogenases/reductases family NP_266304.1 surface polysaccharides, lipopolysaccharides and antigens; short-chain dehydrogenase/reductase family NP_266305.1 TetR/AcrR family of transcription regulators NP_266308.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_266310.1 transport and binding protein; multidrug resistance; similar to several quinolene resistance proteins NorA NP_266312.1 similar to streptodornase (DNAse) from Streptococcus pyogenes NP_266316.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor NP_266317.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor NP_266318.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_266319.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_266320.1 similar to several MutT-like proteins NP_266321.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_266322.1 similar to 6-aminohexanoate-cyclic-dimer hydrolase of Flavobacterium sp. NP_266323.1 damage-inducible protein; adaptations and atypical conditions; similar to DinF protein from Streptococcus pneumoniae NP_266324.1 adaptations and atypical conditions; cold-shock (CSD) family NP_266325.1 similar to 5-formyltetrahydrofolate cyclo-ligase NP_266329.1 similar to outer surface protein of Borrelia burgdorferi NP_266330.1 transport and binding protein; PTS system NP_266331.1 energy metabolism, sugars NP_266332.1 catalyzes the formation of dUMP from dUTP NP_266333.1 similar to several 5'-nucleotidases NP_266334.1 similar to YutD of Bacillus subtilis NP_266335.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_266336.1 aerobic energy metabolism; similar to different oxidoreductases NP_266338.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_266343.1 transport and binding protein, cations; GTP-driven transporter of ferrous ion NP_266344.2 transport and binding protein, cations NP_266345.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_266346.2 similar to hypothetical protein YloV from Bacillus subtilis; probable kinase related to hydroxyacetone kinase, evidenced by COGnitor NP_266347.1 similar to Asp23 protein of Bacillus subtilis encoded by yloU gene; conserved hypothetical akaline shock protein NP_266348.1 required for 70S ribosome assembly NP_266350.1 sugar-nucleotide biosynthesis and interconversions NP_266352.1 sugar-nucleotide biosynthesis and interconversions NP_266354.1 sugar-nucleotide biosynthesis and interconversions NP_266355.1 sugar-nucleotide biosynthesis and interconversions NP_266356.1 surface polysaccharides, lipopolysaccharides and antigens NP_266357.1 surface polysaccharides, lipopolysaccharides and antigens NP_266358.1 transport and binding protein, carbohydrates; organic alcohols and acids; probably involved in side chain formation of rhamnose-glucose polysaccharide NP_266359.1 transport and binding protein, carbohydrates; organic alcohols and acids; probably involved in side chain formation of rhamnose-glucose polysaccharide NP_266362.1 surface polysaccharides, lipopolysaccharides and antigens; probably involved in side chain formation of rhamnose-glucose polysaccharide NP_266365.1 surface polysaccharides, lipopolysaccharides and antigens NP_266367.1 surface polysaccharides, lipopolysaccharides and antigens NP_266368.1 surface polysaccharides, lipopolysaccharides and antigens NP_266369.1 surface polysaccharides, lipopolysaccharides and antigens NP_266370.1 surface polysaccharides, lipopolysaccharides and antigens; similar to Cps19aG protein in LPS gene claster of Streptococcus pneumoniae NP_266371.1 surface polysaccharides, lipopolysaccharides and antigens; similar to many glucosyl or galactosyl transferases involved in polysaccharide biosynthesis NP_266372.1 surface polysaccharides, lipopolysaccharides and antigens; similar to glycosyl transferases NP_266373.1 surface polysaccharides, lipopolysaccharides and antigens; similar to glycerol diester phosphodiesterases NP_266374.1 surface polysaccharides, lipopolysaccharides and antigens NP_266376.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_266377.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis NP_266379.2 GTP-binding protein; counterpart of YnbA of Bacillus subtilis and HflX of Escherichia coli NP_266386.1 similar to YlbM protein of Bacillus subtilis NP_266387.1 similar to BacF protein from Enterococcus faecalis pheromone-responsive conjugative plasmid pPD1 NP_266388.1 similar to YeeN from E. coli NP_266390.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_266393.1 similar to tetR-family transcription regulators NP_266394.1 transport and binding protein; similar to several multidrug resistance proteins NP_266395.1 MerR family of transcription regulators NP_266396.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_266397.1 similar to YpiL and YigE NP_266398.1 similar to Y39C12A.3 protein of Caenorhabditis elegans; similar to YceC, YihA and YpiF NP_266401.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_266402.2 similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone NP_266403.2 helix-turn-helix from TetR family; similar to Y07639 NP_266404.2 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase NP_266405.1 anaerobic energy metabolism; similar to the C-terminal part of dihydroxyacetone kinase from Citrobacter freundii NP_266407.1 transport and binding protein; carbohydrates, organic alcohols and acids NP_266408.1 degradation of proteins, peptides, and glycopeptides; similar to dipeptidase PepD of Lactobacillus helveticus NP_266409.1 TetR/AcrR family of transcription regulators NP_266410.1 transport and binding protein NP_266411.1 transport and binding protein NP_266412.1 UPF0064 family; similar to YwbD of Bacillus subtilis NP_266413.1 gluconeogenesis; similar to fructose-1,6-bisphosphatase of Bacillus subtilis NP_266414.1 similar to YtfP of Bacillus subtilis NP_266415.1 UPF0031 family NP_266417.1 transport and binding protein; contains two ATP binding domains NP_266421.2 aerobic energy metabolism NP_266422.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_266424.1 aerobic energy metabolism; aldo/keto reductase family NP_266425.1 similar to nicotinamidase or pyrazinamidase from Mycobacterium smegmatis NP_266428.1 cell wall hydrolase; muramidase-2 like protein in Enterococcus faecalis; in Enterococcus faecalis a mutant in this gene has no effect on virulence in mouse models; Listeria monocytogenes MurA in involved in general autolysis; contains an N-terminal muramid NP_266429.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_266430.1 salvage of nucleosides and nucleotides NP_266432.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_266433.1 with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene NP_266434.1 with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene NP_266435.1 transport and binding protein NP_266436.1 similar to bacterocin transport accessory protein Bta of Streptococcus pneumoniae; maybe a part of trasport system ychDEF NP_266437.1 similar to acetyltransferases NP_266438.1 energy metabolism, amino acids and amines; similar to several hippurate hydrolases and amino acid amidohydrolases; may be a peptidase. NP_266440.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_266441.1 similar to ydcI of Bacillus subtilis; contains has S1 motif; similar to tex (toxin expression regulator) genes NP_266442.1 similar to adenylate kinase NP_266443.1 catalyzes the formation of inosine from adenosine NP_266447.1 similar to ykzG Bacillus subtilis NP_266449.1 ribosomal proteins; synthesis and modification; similar to several ribosomal-protein-alanine N-acetyltransferases NP_266450.1 ribosomal proteins; synthesis and modification; similar to different ribosomal-protein-alanine acetyltransferases NP_266451.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_266456.1 transport and binding protein, anions NP_266457.1 transport and binding protein, anions NP_266458.1 transport and binding protein, anions NP_266459.1 nucleotide and nucleoside interconversions; similar to nucleotide phosphodiesterases and UDP-sugar hydrolases NP_266460.1 adaptations and atypical conditions; antioxidant activity; may remove peroidases or hydrogen peroxide; TPX/TAGD family NP_266461.1 evidence experimental PMID:1352755; degradation of proteins, peptides, and glycopeptides NP_266462.1 multidrug resistance; similar to NapC protein from Enterococcus hirae; similar to many tetracycline resistance efflux proteins of class H NP_266463.1 similar to NapB protein of Enterococcus hirae NP_266464.1 transort and binding protein, cations; similar to several cation efflux system proteins NP_266466.1 transport and binding protein NP_266467.1 transport and binding protein NP_266468.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_266471.1 similar to BioY protein precursor of Bacillus sphaericus NP_266472.1 regulatory funcion; similar to EbsC regulator of Enterococcus faecalis NP_266474.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins NP_266475.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins NP_266476.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins NP_266477.1 membranes, lipoproteins, and porins; attached to the outer membrance by a lipid anchor; NLPA family of lipoproteins NP_266478.1 transport and binding protein; amino acids, peptides and amines NP_266479.1 transport and binding protein; amino acids, peptides and amines NP_266481.1 transport and binding protein; contains two ATP-binding domains NP_266482.1 transport and binding protein NP_266483.1 PBSX(XRE) family of transcription regulators NP_266484.1 transort and binding protein, cations NP_266485.1 transort and binding protein, cations NP_266487.1 LysR-family regulators; probably cotranscribed with other fhu genes NP_266488.1 transport and binding protein NP_266489.1 aerobic energy metabolism NP_266492.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_266493.1 cellular processes, detoxification; directly reduces organic hydroperoxides; Probably induced by heat shock, salt stress, oxidative stress and glucose limitation; general stress protein NP_266494.1 cellular processes, detoxification; protects the cell against DNA damage by alkyl hydroperoxides; similar to NADH peroxidase nox-1 of Streptococcus mutans NP_266495.1 cell envelope, murein sacculus and peptidoglycan NP_266496.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_266497.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_266498.1 cell envelope murein sacculus and peptidoglycan; MURCDEF family NP_266499.1 transport and binding protein; amino acids, peptides and amines NP_266500.1 transport and binding protein; amino acids, peptides and amines NP_266501.1 transport and binding protein; amino acids, peptides and amines NP_266502.1 transport and binding protein; amino acids, peptides and amines NP_266503.1 transport and binding protein; amino acids, peptides and amines NP_266504.1 transport and binding protein; amino acids, peptides and amines NP_266505.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_266506.1 RNA processing; ATP-dependent RNA-binding protein with helicase activity; similar to DEAD box family helicases NP_266507.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_266508.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP NP_266509.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_266510.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_266511.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_266512.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_266513.1 similar to YlbF protein of Bacillus subtilis; involved in competence and sporulation development NP_266514.1 similar to hypothetical YlbG protein of Bacillus subtilis NP_266516.1 similar to hypothetical YjbK protein Bacillus subtilis NP_266517.1 similar to YoaT protein of Bacillus subtilis NP_266518.2 similar to YjbM protein of Bacillus subtilis NP_266519.1 catalyzes the phosphorylation of NAD to NADP NP_266520.1 RNA synthesis, modification, and DNA transcription; family 2 of pseudouridine synthases NP_266521.1 translation; protein modification NP_266522.1 transport and binding protein; amino acids, peptides and amines; there is another lysine specific permease LysP NP_266524.1 similar to hypothetical protein TP0796 Treponema pallidum NP_266525.1 transposon related function NP_266526.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266527.1 transposon related function NP_266528.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266529.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_266530.1 LysR-family regulators NP_266532.1 glycolysis; similar to malate dehydrogenase NP_266533.1 LysR-family regulators NP_266534.1 similar to exfoliative toxin A; transport and binding protein; tellurite resistance protein or related permease NP_266535.1 Required for the synthesis of the thiazole moiety NP_266536.1 transport and binding protein; multidrug resistance NP_266537.1 fatty acid and phospholipid metabolism NP_266539.1 transort and binding protein, cations NP_266541.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_266542.1 cell envelope, murein sacculus and peptidoglycan NP_266543.1 evidence experimental PMID:8535515; degradation of proteins, peptides, and glycopeptides NP_266545.1 thioredoxin, glutaredoxin, and glutathione; similar to the thioredoxin H-type from plants NP_266546.1 similar to YtpR of Bacillus subtilis and phenylalanine tRNA ligase NP_266547.1 aerobic energy metabolism NP_266548.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_266549.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_266550.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_266551.1 similar to yycJ Bacillus subtilis NP_266552.1 evidence experimental PMID:9172368; two-component systems NP_266553.1 evidence experimental PMID:10708382; two-component systems; involved in acid stress resistance development NP_266554.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_266555.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. NP_266557.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA NP_266560.1 fatty acid and phospholipid metabolism NP_266561.1 fatty acid and phospholipid metabolism NP_266562.1 fatty acid and phospholipid metabolism NP_266563.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate NP_266564.1 evidence experimental PMID:7665513; cellular processes, detoxification NP_266565.1 adaptations and atypical conditions; peptide utilization during carbon starvation NP_266566.1 RNA processing; ATP-dependent RNA-binding protein with helicase activity; similar to other DEAD box family helicases NP_266568.1 RpiR family of transcription regulators NP_266569.1 transport and binding protein; PTS system NP_266570.1 transport and binding protein; PTS system NP_266571.1 RpiR family of transcription regulators NP_266572.1 transport and binding protein; PTS system NP_266573.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism NP_266575.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_266576.1 similar to YegS from E. coli NP_266577.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_266578.1 electron transport; oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin which reduces nitrogenase NP_266580.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_266582.1 similar to C part of PTS protein NP_266583.2 transport and binding protein; PTS system NP_266584.1 similar to Lactococcus lactis ATCC 19435 protein Y18267 NP_266585.1 evidence experimental PMID:9084169; glycolysis NP_266586.1 energy metabolism, sugars; similar to beta-1,4-D-xylanase of Butyrivibrio fibrisolvens NP_266591.1 belongs to LytR family NP_266592.1 prophage pi1 protein 01; similar to integrase of Lactococcus lactis phage BK5-T NP_266593.1 similar to orf3 of Lactococcus lactis phage TP901-1 NP_266594.1 transcription regulator; evidence experimental PMID:8730874; similar to the repressor protein Rro of Lactococcus lactis phage r1t. cI type regulator NP_266595.1 transcription regulator; similar to BK5-T phage repressor protein Cro NP_266598.1 similar to tec gene product of bacteriophage r1t NP_266599.1 similar to orf5 of the phage r1t NP_266600.1 similar to orf6 of bacteriophage r1t NP_266601.1 transcription regulator; similar to orf8 of bacteriophage r1t, similar to Cro repressor protein of the phage BK5-T NP_266602.1 prophage pi1 protein 11; similar to a recombinase of the Listeria monocytogenes bacteriophage A118 NP_266604.2 prophage pi1 protein 13; similar to a replisome organiser protein Rep2009 of the bacteriophage Tuc2009 NP_266605.2 prophage pi1 protein 14; similar to the orf12 of the phage r1t; functional equivalent to DnaC of Escherichia coli or DnaI of Bacillus subtilis, which are required for chromosomal replication NP_835293.1 similar to bacteriophage bIL309 Orf16 NP_835294.1 similar to bacteriophage bIL309 Orf18 NP_266607.1 similar to orf18 of bacteriophage r1t NP_266610.1 similar to orf24 of the bacteriophage Tuc2009 NP_266611.1 prophage pi1 protein 16; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t NP_266613.1 similar to orf17 of bacteriophage o1205 NP_835295.1 similar to bacteriophage bIL309 Orf27 NP_266614.1 similar to orfx from lactococcal bacteriophage 712 NP_266617.1 similar to orf4 of abiN locus from Lactococcus lactis S114 accession number Y11901 NP_266618.1 similar to Orf20 of S.thermophilus bacteriophage o1205 NP_266619.1 similar to orf4 of abiN locus from Lactococcus lactis S114 accession number Y11901 NP_266620.1 similar to the 64 protein (GP64) from Mycobacteriophage l5 NP_266622.1 similar to orf6 of abiN locus from Lactococcus lactis S114 accession number Y11901 NP_266624.1 prophage pi1 protein 33; similar to small subunit (orf152 gp) of terminase from Streptococcus thermophilus bacteriophage Sfi21 NP_266625.1 prophage pi1 protein 34; similar to large subunit (orf623 gp) of terminase from Streptococcus thermophilus bacteriophage Sfi21 NP_835297.1 similar to bacteriophage bIL309 Orf40 NP_266626.1 similar to a hypothetical protein of Lactobacillus bacteriophage phi adh accession number AJ131519 NP_266627.1 prophage pi1 protein 36; similar to orf26 of Bacillus subtilis bacteriophage phi-105 NP_266628.1 prophage pi1 protein 37; similar to orf27 of Bacillus subtilis bacteriophage phi-105, encoding capsid protein NP_266630.1 similar to head-tail joining protein (orf10) of Streptococcus thermophilus bacteriophage DT1 NP_266631.1 tail component; similar to tail component protein (Orf11) of Streptococcus thermophilus bacteriophage DT1 NP_266632.1 tail component; similar to a tail component protein (Orf12) of Streptococcus thermophilus bacteriophage DT1 NP_266633.1 prophage pi1 protein 42; similar to small major structural protein of Streptococcus thermophilus phage phi7201 accession number AF001793) NP_266635.1 tail component; similar to tail component protein (Orf15) of Streptococcus thermophilus bacteriophage DT1 NP_266636.1 tail component; similar to tail component protein (Orf17) of Streptococcus thermophilus bacteriophage DT1 NP_266637.1 tail component; similar to tail-host specificity protein (Orf18) of Streptococcus thermophilus bacteriophage DT1 NP_266639.1 similar to holin of Staphylococcus aureus bacteriophage phi PVL, similar to orf95 of Lactococcus lactis phage BK5-T NP_266640.1 prophage pi1 protein 49; similar to orf259 of Lactococcus lactis phage BK5-T NP_266642.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_266643.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_266645.1 similar to YwlG protein from Bacillus subtilis NP_266646.1 energy metabolism; similar to several amino acid aminotransferases NP_266647.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_266652.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. NP_266653.1 cell killing NP_266654.1 similar to DegV of Bacillus subtilis NP_266656.1 similar to glycosyl hyrolases NP_266658.1 DNA replication, restriction, modification, recombination, and repair NP_266659.1 prophage ps2 protein 01 NP_266662.1 similar to gp17v protein of Escherichia coli bacteriophage KVP40 NP_266663.1 prophage ps2 protein 05; similar to Rad protein of Lactobacillus bacteriophage phi adh NP_266664.1 similar to Orf65a of Lactobacillus bacteriophage phi adh NP_266665.1 prophage ps2 protein 07; similar to excisionase of Streptococcus pneumoniae transposon Tn5252 NP_266673.1 similar to Orf11 of Staphlococcus aureus transposon Tn557 NP_266677.1 similar to Orf26 of Bacillus subtilis bacteriophage phi-105 NP_266685.1 adaptations and atypical conditions; cold-shock domain family (CSD) NP_266686.1 regulatory function NP_266687.1 DNA replication, restriction, modification, recombination, and repair NP_266689.1 transport and binding protein NP_266690.1 transport and binding protein NP_266693.1 energy metabolism, electron transport; similar to NifZ of Bacillus subtilis; cysteine sulfinate desulfinase/cysteine desulfurase, evidenced by COGnitor NP_266695.1 transport and binding protein; amino acids, peptides and amines; probably a substrate binding protein of an oligopeptide or aminoacid ABC transporter NP_266696.1 serine family NP_266697.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis NP_266699.1 cell envelope, murein sacculus and peptidoglycan NP_266700.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC NP_266703.1 similar to YktA protein of Bacillus subtilis NP_266704.2 similar to myo-inositol monophosphatases NP_266705.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_266707.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_266708.1 synthesizes RNA primers at the replication forks NP_266709.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium NP_266710.1 RpiR family of transcription regulators NP_266711.1 transport and binding protein, carbohydrates, organic alcohols and acids; similar to Lactococcus lactishexose phosphate transport in Accession Number X71493 NP_266713.1 evidence experimental PMID:10094684; adaptations and atypical conditions; CLPC subfamily NP_266715.1 evidence experimental PMID:7773380; glycolysis NP_266716.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_266717.1 hydrolyzes diadenosine polyphosphate NP_266718.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_266719.1 transport and binding protein; amino acids, peptides and amines NP_266720.1 glutamate family; fifth step in arginine biosynthesis NP_266721.1 fatty acid and phospholipid metabolism NP_266722.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_266724.1 transport and binding protein NP_266725.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site NP_266727.1 similar to several membrane proteins NP_266728.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. NP_266729.1 biosynthesis of cofactors; prosthetic groups, and carriers; apparently the middle part of the protein; probably involved in pantothenate metabolism NP_266730.1 central intermediary metabolism NP_266731.1 transort and binding protein, cations NP_266732.1 paralogous to yafE NP_266744.1 DNA replication, restriction, modification, recombination, and repair; evidence experimental PMID:9097419; involved in UV protection and mutagenesis; may modify DNA replication machinery to allow bypass through a damaged template NP_266747.1 MarR-family regulators NP_266749.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_266751.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_266753.1 electron transport NP_266754.1 heme and porphyrin; may be involved in the oxidation of protoporphyrinogen into protoporphyrin IX NP_266755.1 probably an acetyltransferase NP_266757.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_266758.1 transposon related function; similar to Orf14 of Enterococcus faecalis transposon Tn916 NP_266759.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine NP_266760.1 serine family; similar to N-terminal part of SerA NP_266761.1 serine family NP_266762.1 catalyzes the hydrolysis of acylphosphate NP_266763.1 RNA synthesis, modification, and DNA transcription NP_266764.2 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_266765.1 transport and binding protein; multidrug resistance; similar to many multidrug resistance transporters NP_266768.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides NP_266769.1 probably tRNA-processing ribonuclease; similar to ribonuclease BN; evidenced by COGnitor NP_266774.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_266775.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_266776.1 similar to a tropomyosin-related protein STRP from Saccharomyces cerevisiae NP_266778.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_266779.1 transort and binding protein, cations NP_266780.1 transort and binding protein, cations NP_266781.1 similar to YqfU of Bacillus subtilis NP_266782.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_266784.1 probably membrane protease subunit; evidenced by COGnitor NP_266786.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions NP_266787.1 aerobic energy metabolism NP_266789.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_266790.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_266791.1 similar to YrrL of Bacillus subtilis NP_266792.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_266793.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase NP_266794.1 transposon related function NP_266795.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase NP_266796.1 transposon related function NP_266797.1 transctiptional regulator; adaptations and atypical conditions; regulator of class III stress genes (clpC, clpP) NP_266798.1 evidence experimental PMID:10094684; adaptations and atypical conditions; CLPC subfamily NP_266800.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_266801.1 DNA replication, restriction, modification, recombination, and repair NP_266808.1 DNA replication, restriction, modification, recombination, and repair; evidence experimental PMID:9593305; subunit S dictates DNA sequence specificity NP_266813.1 evidence experimental PMID:8389385; transposon related function. related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_266814.1 transposon related function; orf1 of IS981 NP_266815.1 transport and binding protein NP_266816.1 transport and binding protein NP_266817.1 TetR/AcrR family of transcription regulators NP_266818.1 fatty acid and phospholipid metabolism NP_266819.1 transort and binding protein; cations NP_266820.1 evidence experimental PMID:9294449; energy metabolism; fermentation NP_266821.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_266822.1 transport and binding protein; multidrug resistance; similar to PmrA of Streptococcus pneumoniae NP_266823.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_266824.1 cell division protein; similar to cell division protein FtsW of Enterococcus hirae NP_266825.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate NP_266826.2 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_266827.1 Catalyzes the conversion of citrate to isocitrate NP_266828.1 TCA cycle; glutamate synthesis NP_266829.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_266831.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress NP_266834.1 transort and binding protein, cations NP_266836.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaA of Staphylococcus epidermidis NP_266837.1 transposon related function; belongs to the IS30 family of transposase NP_266838.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaB of Staphylococcus epidermidis NP_266839.1 similar to peptidoglycan bound protein NP_266840.1 surface polysaccharides, lipopolysaccharides and antigens; mediates attachement of cells to collagen containing substrates NP_266841.1 probably ATPase with chaperone activity, ATP-binding domain, evidenced by COGnitor NP_266843.1 hydrolase of PHP superfamily NP_266844.1 similar to Listeria monocytogenes FlaR NP_266846.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_266847.1 evidence experimental PMID:9797327; degradation of proteins, peptides, and glycopeptides NP_266848.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_266850.1 transcription termination protein; RNA synthesis, modification, and DNA transcription NP_266853.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate NP_266854.1 central intermediary metabolism; subunit of ADP-glucose pyrophosphorylase NP_266855.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose NP_266856.1 central intermediary metabolism NP_266857.1 degradation of polysaccharides NP_266858.1 evidence experimental PMID:8157671; transport and binding protein; amino acids, peptides and amines NP_266859.1 transposon related function; belongs to the IS30 family of transposase NP_266860.1 energy metabolism; electron transport NP_266861.1 energy metabolism; electron transport NP_266862.2 transport and binding protein; multidrug resistance; involved in the cytochrome D branch of aerobic respiration; MDR subfamily NP_266863.1 transport and binding protein; multidrug resistance; involved in the cytochrome D branch of aerobic respiration; MDR subfamily NP_266864.1 MarR-family regulators; belongs to the MarR family NP_266866.1 similar to several proteins from eukaryotes NP_266867.1 evidence experimental PMID:8855237; transport and binding protein; multidrug resistance NP_266869.1 phosphorus compounds; complements a phoA mutation in Escherichia coli NP_266870.1 transport and binding protein NP_266871.1 similar to hypothetical protein MJ1230 of Methanococcus jannaschii NP_266873.1 energy metabolism; electron transport NP_266874.1 probably methionine synthase II, evidenced by COGnitor NP_266875.1 probably metal-dependent hydrolase, evidenced by COGnitor NP_266876.1 probably protein phosphatase, evidenced by COGnitor NP_266877.1 probably amino acid deaminase, evidenced by COGnitor NP_266878.1 evidence experimental PMID:8389385; transposon related function. related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_266879.1 transposon related function; orf1 of IS981 NP_266880.1 similar to C-terminal parts of alpha-glucosidases from differenr species NP_266881.1 LacI-family regulators NP_266882.1 similar to ComAB (YuxO) protein of Bacillus subtilis NP_266883.1 menaquinone and ubiquinone; probably involved in menaquinone biosynthesis NP_266884.2 menaquinone and ubiquinone NP_266885.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_266886.1 menaquinone and ubiquinone; counterpart of Bacillus subtilis YtxM NP_266887.1 menaquinone and ubiquinone NP_266888.1 menaquinone and ubiquinone NP_266889.1 ribosomal proteins: synthesis and modification NP_266890.1 similar to YtoI of Bacillus subtilis NP_266891.1 similar to YtqI of Bacillus subtilis NP_266892.1 energy metabolism, amino acids and amines NP_266895.1 surface polysaccharides, lipopolysaccharides and antigens; similar to flotillin NP_266896.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive NP_266897.1 probably phosphoesterase, evidenced by COGnitor NP_266898.1 MarR-family regulators NP_266899.1 Similar to phosphoglucomutases and phosphoglycolate phosphatases from different species NP_266900.1 similar to YybT of Bacillus subtilis NP_266901.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_266902.1 DNA replication, restriction, modification, recombination, and repair; corresponds to the dnaC gene from Bacillus subtilis NP_266904.1 similar to YtmP of Bacillus subtilis NP_266905.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_266907.1 DNA replication, restriction, modification, recombination, and repair; replication protein; counterpart to the Bacillus subtilis DnaB protein, based on sequence similarity and chromosomal position NP_266908.1 Primosomal protein that may act to load helicase DnaC during DNA replication NP_266909.1 aerobic energy metabolism NP_266910.1 similar to YisX of Bacillus subtilis NP_266911.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_266912.1 similar to positive regulator GadR of Lactococcus lactis NP_266915.1 similar to fimbria-associated protein from Actinomyces naeslundii; integral membrane protein NP_266917.1 integral membrane protein NP_266918.1 similar to PH1801 of Pyrococcus horikoshii. NP_266919.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_266920.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_266922.1 ribosomal proteins; synthesis and modification; similar to YlxQ of Bacillus subtilis, supposed to be a ribosomal protein. Located close to the genes implicated in protein biosynthesis. NP_266923.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_266924.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_266926.1 MarR-family regulator NP_266927.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_266928.1 carries the fatty acid chain in fatty acid biosynthesis NP_266929.1 fatty acid and phospholipid metabolism NP_266930.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_266931.1 fatty acid and phospholipid metabolism NP_266932.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_266933.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_266934.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_266935.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_266936.1 fatty acid and phospholipid metabolism NP_266937.1 catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine NP_266938.1 serine family; there is another potential cysteine synthase cysM in the genome NP_266942.1 aerobic energy metabolism NP_266943.1 similar to YrkD of Bacillus subtilis NP_266945.1 DeoR-family regulators NP_266946.1 ribosomal proteins: synthesis and modification NP_266947.1 degradation of DNA; AP/EXOA family of DNA repair enzymes NP_266948.1 amino acyl tRNA synthetases NP_266950.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_266952.1 similar to YwnB protein of Bacillus subtilis; probably nucleoside-diphosphate-sugar epimerase, evidenced by COGnitor NP_266953.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_266954.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate NP_266955.1 glutamate family NP_266956.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate NP_266957.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway NP_266958.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_266965.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_266968.1 integral membrane protein NP_266969.1 cell division protein NP_266970.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_266972.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_266973.1 RpiR family of transcription regulators NP_266974.1 transport and binding protein; PTS system NP_266975.1 energy metabolism, Sugars; beta-glucosidase family NP_266976.1 adaptations and atypical conditions; belongs to chloro/bromoperoxidase family. NP_266978.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266979.1 transposon related function NP_266980.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase NP_266981.1 transposon related function NP_266982.1 transposon related function NP_266983.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_266984.1 aerobic energy metabolism NP_266985.1 aerobic energy metabolism NP_266986.1 energy metabolism, amino acids and amines; gluconeogenesis; produces pyruvate NP_266987.1 energy metabolism, amino acids and amines; gluconeogenesis; produces pyruvate NP_266988.1 general regulatory function NP_266989.1 transport and binding protein, cations; similar to N-part of many mercuric reductases; probably involved in cation transport, because of the visinity of corresponding genes NP_266990.1 transort and binding protein, cations NP_266991.1 identified also as transmembrane protein Tmp5. similar to YfhO of Bacillus subtilis NP_266993.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_266994.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_266995.1 salvage of nucleosides and nucleotides NP_266996.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_266998.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases NP_266999.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_267000.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer NP_267002.1 thioredoxin, glutaredoxin, and glutathione NP_267003.1 transport and binding protein; amino acids, peptides and amines; maybe involved in osmoprotection; substrate can be also proline or glycine NP_267004.1 transport and binding protein; amino acids, peptides and amines; maybe involved in osmoprotection; substrate can be also proline or glycine; permease and substrate binding functions are in the same protein NP_267007.1 transort and binding protein, cations NP_267009.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_267010.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_267011.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_267013.1 menaquinone and ubiquinone; side chain synthesis, also isoprenoid, carotenoid biosynthesis; belongs to a family that groups together FFP synthetase, GGPP synthetase and hexaprenyl pyrophosphate synthetase NP_267014.1 hemolysin-like protein; similar to hemolysin A NP_267015.1 similar to several AhrC proteins from different species NP_267016.1 DNA replication, restriction, modification, recombination, and repair; may be involved in recombinational repair of damaged DNA NP_267019.1 transport and binding protein NP_267022.1 membrane protein NP_267023.1 cell envelope, murein sacculus and peptidoglycan NP_267024.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_267026.1 transport and binding protein NP_267028.1 evidence experimental PMID:2498286; LysR-family regulators NP_267029.1 similar to YwaC of Bacillus subtilis NP_267030.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_267032.1 surface polysaccharides, lipopolysaccharides and antigens; similar to intercellular adhesion locus protein IcaA of Staphylococcus epidermidis NP_267034.1 transport and binding protein; nucleosides, purines and pyrimidines NP_267036.1 DNA replication, restriction, modification, recombination, and repair NP_267037.1 belongs to TetR/AcrR family NP_267038.1 transmembrane protein, similar to phage infection protein Pip NP_267039.1 probably aromatic ring hydroxylating enzyme, evidenced by COGnitor NP_267040.1 cell division protein; similar to cell division protein FtsW of Enterococcus hirae NP_267046.1 evidence experimental PMID:9172368; two-component system NP_267047.1 evidence experimental PMID:10708382; two-component system; involved in salt and osmotic stress resistance development NP_267049.1 translation; protein modification NP_267050.1 adaptations and atypical conditions; polyribonucleotide nucleotidyltransferase NP_267052.1 cell division; similar to rod-shape determining proteins from different species NP_267053.2 energy metabolism; fermentation NP_267054.1 fermentation NP_267055.1 transport and binding protein; contains two ATP binding domains NP_267056.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate NP_267057.1 evidence experimental PMID:8405453; transport and binding protein; carbohydrates, organic alcohols and acids NP_267061.1 negatively supercoils closed circular double-stranded DNA NP_267064.1 MarR-family regulators NP_267065.1 transport and binding protein NP_267067.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000 NP_267068.1 surface polysaccharides, lipopolysaccharides and antigens; similar to EpsL protein of exopolysaccharide biosynthesis operons of S.thermophilus and l.lactis NIZO B35 NP_267070.1 transort and binding protein, cations NP_267071.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267072.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267074.1 surface polysaccharides, lipopolysaccharides and antigens NP_267075.1 surface polysaccharides, lipopolysaccharides and antigens NP_267077.1 surface polysaccharides, lipopolysaccharides and antigens NP_267078.1 surface polysaccharides, lipopolysaccharides and antigens NP_267080.1 surface polysaccharides, lipopolysaccharides and antigens NP_267082.1 surface polysaccharides, lipopolysaccharides and antigens NP_267083.1 surface polysaccharides, lipopolysaccharides and antigens NP_267084.1 LytR family NP_267085.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_267087.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_267088.1 transposon related function; belongs to the IS30 family of transposase NP_267091.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_267092.1 probably cell wall-associated hydrolase, evidenced by COGnitor NP_267093.1 transport and binding protein; amino acids, peptides and amines NP_267094.1 transport and binding protein; amino acids, peptides and amines NP_267095.1 transport and binding protein; amino acids, peptides and amines NP_267096.1 thioredoxin, glutaredoxin, and glutathione; cofactor FAD flavoprotein; pyridine nucleotide-disulfide oxidoreductase class-II. NP_267097.1 protein and peptide secretion; involved in protein export; early event of protein translocation NP_267098.1 degradation of RNA; ribonuclease II (RNB) family NP_267099.1 probably amidase, evidenced by COGnitor NP_267101.1 similar to 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Bacillus subtilis NP_267102.1 ACT domain-containing protein NP_267103.1 similar to MJ1665 protein of Methanococcus jannaschii. NP_267105.1 glycolysis NP_267106.1 murein sacculus and peptidoglycan; in Enterococcus faecalis corresponding enzyme mediates vancomycin resistance NP_267108.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_267109.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_267110.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_267111.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever NP_267112.1 energy metabolism, amino acids and amines; similar to several hippurate hydrolases and amino acid amidohydrolases; may be a peptidase NP_267113.1 evidence experimental PMID:2120234; DeoR-family regulator; repressor of the lactose catabolism operon; galactose 6-phosphate is the inducer NP_267114.1 galactose metabolism NP_267115.2 transport and binding protein; PTS system NP_267116.1 membranes, lipoproteins, and porin; affects resistance to gyrase inhibitor novobiocin; condensationof two molecules of phosphatidylglycerol NP_267117.1 similar to YvcJ of Bacillus subtilis NP_267118.1 similar to YvcK of Bacillus subtilis NP_267119.1 similar to YvcL of Bacillus subtilis NP_267120.1 similar to tetR-family transcription regulators NP_267121.1 transport and binding protein NP_267122.1 transport and binding protein NP_267124.1 transport and binding protein NP_267125.1 similar to hypothetical YgaC protein from Bacillus subtilis NP_267127.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_267128.1 cell division NP_267129.1 cell division NP_267130.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_267131.1 Catalyzes the rate-limiting step in dNTP synthesis NP_267132.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_267133.1 glutaredoxin-like protein; energy metabolism, electron transport; electron transport system for ribonucleotide reductase system NrdEF NP_267134.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX NP_267135.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_267138.1 DNA replication, restriction, modification, recombination, and repair; exhibits 3' to 5' exonuclease activity NP_267140.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_267149.1 riboflavin and cobalamin; converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinone 5'-phosphate NP_267150.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_267151.1 riboflavin and cobalamin; GTP cyclohydrolase II NP_267152.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_267153.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_267154.1 RNA synthesis, modification, and DNA transcription; responsible for synthesis of pseudouridine from uracil-2650 in 23S ribosomal RNA; belongs to family two of pseudouridine synthases NP_267158.1 evidence experimental PMID:10708382; two-component system; involved in phosphatase expression NP_267160.1 evidence experimental PMID:9172368; two-component systems NP_267161.1 probably phosphatase, evidenced by COGnitor NP_267162.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_267163.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase NP_267164.1 prophage pi2 protein 01; similar to integrase of Lactococcus lactis phage BK5-T NP_267165.1 similar to Orf3 of bacteriophage TP901-1 NP_267166.1 similar to Orf2 of bacteriophage TP901-1 NP_267167.1 prophage pi2 protein 04; similar to Orf4 of bacteriophage TP901-1 NP_267168.1 similar to Orf5 of bacteriophage TP901-1 NP_267169.1 similar to Orf6 of bacteriophage TP901-1 NP_267170.1 similar to Orf111 of bacteriophage BK5-T NP_835341.1 similar to prophage pi3 protein 53 NP_267171.1 similar to Orf10 of bacteriophage Tuc2009 NP_267172.1 similar to Orf71 of bacteriophage phi31 NP_267173.1 similar to Orf13 of bacteriophage Tuc2009 NP_267174.1 prophage pi2 protein 11; similar to topoisomerase I of bacteriophage Tuc2009 NP_267175.1 prophage pi2 protein 12 NP_267176.1 prophage pi2 protein 13; similar to Rep2009 of bacteriophage Tuc2009 NP_267177.1 similar to Orf17 of bacteriophage Tuc2009 NP_267178.1 similar to Orf19 of bacteriophage Tuc2009 NP_267179.1 similar to Orf15 of bacteriophage r1t NP_835306.1 similar to prophage pi3 protein 43 NP_835342.1 similar to prophage pi3 protein 41 NP_267181.1 similar to Orf22 of bacteriophage Tuc2009 NP_835343.1 similar to prophage pi1 protein 17 NP_267183.1 similar to Orf24 of bacteriophage Tuc2009 NP_267184.1 prophage pi2 protein 21; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t NP_835307.1 similar to bacteriophage bIL285 Orf31 NP_835308.1 similar to bacteriophage bIL285 Orf32 NP_835309.1 similar to bacteriophage bIL285 Orf33 NP_835310.1 similar to bacteriophage bIL285 Orf35 NP_267189.1 similar to Lactococcus lactis S114 hypothetical protein accession number Y11901 NP_267193.1 prophage pi2 protein 30; similar to Orf22 of bacteriophage phi-105 NP_267195.1 similar to Orf26 of bacteriophage phi-105 NP_267196.1 prophage pi2 protein 33; similar to capsid protein of S.aureus bacteriophage phi PVL NP_267202.1 similar to Orf34 of Bacillus subtilis bacteriophage phi-105 NP_267205.1 similar to protein l16 of bacteriophage bil170 NP_267206.1 similar to Orf247 of Lactobacillus gasseri bacteriophage phi adh NP_267207.1 similar to a part of hypothetical protein BB0262 of Borrelia burgdorferi NP_267213.1 similar to Orf75 of Lactococcus lactis phage BK5-T NP_267216.1 modulates transcription in response to the NADH/NAD(+) redox state NP_267218.1 transport and binding protein. contains two ATP binding domains NP_267222.1 similar to positive regulator GadR of Lactococcus lactis NP_267224.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_267225.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_267226.1 component of primosome NP_267227.1 degradation of DNA; endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate NP_267235.1 ribosomal proteins; synthesis and modification; binds 23S rRNA in presence of protein L20; L21P family of ribosomal proteins NP_267237.1 involved in the peptidyltransferase reaction during translation NP_267240.1 adaptations and atypical conditions NP_267241.1 probably ADP-ribose pyrophosphatase or mutT, evidenced by COGnitor NP_267245.1 competence protein; transformation; ATP-dependent RNA/DNA helicase involved in DNA transport NP_267246.1 competence protein; transformation; ATP-dependent RNA/DNA helicase involved in DNA transport NP_267248.1 similar to teicoplanin resistance protein of transposon Tn1546 of Enterococcus faecium NP_267249.1 integral membrane protein NP_267250.1 nucleotide and nucleoside interconversions NP_267251.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_267252.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_267255.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_267256.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_267258.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_267259.1 transport and binding protein NP_267260.1 transport and binding protein NP_267261.1 riboflavin and cobalamin; similar to cobyric acid synthase CobQ of Heliobacillus mobilis, cobalamin biosynthesis pathway NP_267262.1 similar to UDP-N-acetylmuramyl tripeptide synthetase MurC of Heliobacillus mobilis NP_267263.1 fermentation; converts acetolactate into actoin or diacetyl NP_267264.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_267265.1 anaerobic energy metabolism; similar to YhfK of Bacillus subtilis and to several hypothetical proteins NP_267266.1 transport and binding protein; amino acids, peptides and amines NP_267267.1 negatively supercoils closed circular double-stranded DNA NP_267269.1 probably an integral membrane protein NP_267273.1 probably an integral membrane protein; C-part similar to lysyl tRNA synthetase NP_267276.1 UvrD subfamily of helicases NP_267277.1 MutT NP_267278.1 hydrolysis of the deoxyribose N-glycosidc bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions NP_267280.1 Reduces fumarate to succinate in anaerobic bacterial respiration NP_267282.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_267283.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_267284.1 glycolysis NP_267285.1 surface protein NP_267286.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_267287.1 transport and binding protein; PTS system NP_267288.1 transport and binding protein; PTS system; similar to beta-glucoside-specific PTS system IIABC component NP_267289.1 RpiR family of transcription regulators NP_267290.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_267291.1 drug and analog sensitivity NP_267295.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_267297.1 2'-deoxyribonucleotide metabolism NP_267299.1 amino sugars NP_267301.1 purine ribonucleotide biosynthesis; similar also to inosine-5'-monophosphate dehydrogenases; maintains the intracellular balance of A and G nucleotides NP_267302.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_267303.1 transport and binding protein; nucleosides, purines and pyrimidines NP_267306.1 evidence experimental PMID:7574597; folic acid NP_267307.1 binds and unfolds substrates as part of the ClpXP protease NP_267308.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_267309.1 folic acid NP_267310.1 GTP-CH-I; folic acid NP_267311.1 folic acid NP_267313.1 folic aci NP_267314.1 nucleotide and nucleoside interconversions; heterodimer of a deoxyadenosine and a deoxyguanosine kinase NP_267315.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_267316.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_267318.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_267319.1 transport and binding protein; amino acids, peptides and amines NP_267320.1 transport and binding protein; amino acids, peptides and amines NP_267321.1 transport and binding protein; amino acids, peptides and amines NP_267322.1 transport and binding protein; amino acids, peptides and amines NP_267323.1 general regulatory function NP_267324.1 probably Fe-S oxidoreductase, evidenced by COGnitor NP_267330.1 membranes, lipoproteins, and porinsl affects resistance to gyrace inhibitor novobiocin; condensation of two molecules of phosphattidylglycerol NP_267331.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_267332.1 RpiR family of transcription regulators NP_267334.1 probably a SAM-dependent RNA methyltransferase, evidenced by COGnitor NP_267336.1 probably a methylase, involved in menaquinone biosynthesis, evidenced by COGnitor NP_267338.1 transport and binding protein NP_267340.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase NP_267342.1 fermentation NP_267343.1 DeoR-family regulators NP_267344.1 TCA cycle NP_267345.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate NP_267346.1 TCA cycle NP_267347.1 TCA cycle NP_835314.1 similar to protease NP_267351.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_267352.1 transposon related function; orf1 of IS981 NP_267358.1 transposon related function; orf1 of IS981 NP_835315.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000 NP_267360.1 evidence experimental PMID:8195098; transposon related function NP_267361.1 degradation of RNA; ribonuclease II (RNB) family NP_267362.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis NP_267364.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ NP_267365.1 evidence experimental PMID:1400209; histidine family NP_267366.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis NP_267367.1 drug and analog sensitivity NP_267368.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_267369.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide NP_267370.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_267371.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_267372.1 histidine family NP_267374.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis NP_267376.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_267377.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D NP_267378.2 transport and binding protein; branched chain amino acid biosynthesis operon NP_267379.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_267380.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit NP_267381.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit NP_267382.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_267383.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic NP_267384.1 evidence experimental PMID:8779600; fermentation; converts acetolactate into acetoin;may be a mechanism for controlling the internal pH of cells in stationary phase NP_267385.1 regulatory protein; general regulatory function NP_267386.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_267387.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_267388.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS NP_267392.1 LysR-family regulator NP_267393.1 evidence experimental PMID:7744873; aspartate family; component of sucrose-nisin transposon Tn5306 NP_267394.1 similar to C-part of 37 kD protein from sucrose-nisin transposon Tn5306 NP_267395.1 similar to a 20 kD protein from sucrose-nisin transposon Tn5306 NP_267396.1 similar to a 6-kDa protein from sucrose-nisin transposon Tn5306 NP_267398.1 similar to YdaS of Bacillus subtilis NP_267399.1 aerobic energy metabolism NP_267400.1 transport and binding protein, carbohydrates; organic alcohols and acids; glycerol utilization pathway NP_267401.1 anaerobic energy metabolism; glycerol utilization pathway NP_267402.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_267404.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_267405.1 transposon related function; orf1 of IS981 NP_267407.1 converts 1,4-alpha-D-glucans to maltodextrin NP_267408.1 anaerobic energy metabolism; L-lactate utilization gene NP_267409.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive NP_267410.1 aspartate family NP_267411.2 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_267412.1 general regulatory function NP_267413.1 transort and binding protein, cations NP_267415.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid NP_267416.1 surface polysaccharides, lipopolysaccharides and antigens; may be involved in transport of activated D-alanine through the membrane NP_267417.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid NP_267419.1 thiamine; also functions in a salvage pathway NP_267420.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_267421.1 surface polysaccharides, lipopolysaccharides and antigens; glycosyltransferase, probably involved in cell wall biogenesis, evidenced by COGnitor NP_267422.1 surface polysaccharides, lipopolysaccharides and antigens NP_267424.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_267425.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_267427.1 general regulatory function NP_267428.1 transport and binding protein NP_267429.1 transport and binding protein NP_267431.2 RNA synthesis, modification, and DNA transcription; synthesis of pseudouridine from uracil-2650 in 23S ribosomal RNA; family 1 of pseudouridine synthases NP_267432.2 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer NP_267433.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB NP_267434.2 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_267440.1 aspartate family NP_267441.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate NP_267442.1 glutamate family; nitrogen metabolism; brings together nitrogen and carbon metabolism NP_267443.1 sugars NP_267444.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_267445.1 integral membrane protein NP_267446.1 evidence experimental PMID:9484886; energy metabolism, amino acids and amines NP_267447.1 evidence experimental PMID:9484886; transport and binding protein; amino acids, peptides and amines NP_267448.1 evidence experimental PMID:9484886; activates chloride dependent transcription of gadCB ,homologous to the activator Rgg from Streptococcus gordonii. NP_267449.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_267450.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_267453.1 DeoR-family regulator NP_267457.1 similar to internalin of Listeria monocytogenes; membrane protein NP_267458.1 transort and binding protein, cations NP_267459.1 transposon related function; belongs to the IS30 family of transposase NP_267460.1 energy metabolism, amino acids and amines NP_267461.1 MarR-family regulator NP_267462.1 LysR-family regulator NP_267465.1 aerobic energy metabolism NP_267466.1 AraC-family regulator; similar to OruR of Pseudomonas aeruginosa. NP_267470.1 folic acid; folate biosynthesis pathway NP_267471.1 folic acid; folate biosynthesis pathway NP_267472.1 transport and binding protein, cations; belongs to streptococcal LraI protein family, involved on adherence to extracellular matrix, important factor in the pathogenesis and infection NP_267473.1 transort and binding protein, cations NP_267474.1 transort and binding protein, cations NP_267477.1 degradation of DNA; affects genetic recombination and the variability of DNA palindromes; may have nuclease activity related to RecBCD NP_267478.1 degradation of DNA; probably involved in genetic recombination NP_267479.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis NP_267483.1 transport and binding protein; similar to fibronectin-binding proteins of Streptococci NP_267484.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267485.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267486.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267487.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH NP_267488.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_267489.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_267491.1 amino sugars NP_267492.1 similar to YaaN of Bacillus subtilis NP_267493.1 similar to 5-bromo-4-chloroindolyl phosphate hydrolysis protein NP_267494.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_267495.1 surface polysaccharides, lipopolysaccharides and antigens; hyaluronate synthesis pathway NP_267496.1 contains signal peptide NP_267499.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_267500.1 similar to cytochrome oxidase subunit III NP_267501.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_267502.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits NP_267503.1 pyrimidine ribonucleotide biosynthesis NP_267504.1 transport and binding protein; multidrug resistance; similar to LmrB of Bacillus subtilis NP_267515.1 transposon related function; belongs to the IS30 family of transposase NP_267519.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_267520.2 thioredoxin, glutaredoxin, and glutathione; cellular metabolism or defense processes NP_267521.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis; similar to Orf39 of Bacillus subtilis bacteriophage phi-105 NP_267522.1 transort and binding protein, cations NP_267524.1 similar to a hydrophobic protein of Lactobacillus fermentum accession number U97348 NP_267526.1 similar to unknown protein MTH1490 of Methanobacterium thermoautotrophicum NP_267527.1 similar to hypothetical membrane protein LaaN NP_267529.1 adaptations and atypical conditions NP_267531.1 similar to orf258 of Lactococcus lactis phage BK5-T NP_267535.1 prophage pi3 protein 05; similar to Orf259 of Lactococcus lactis phage BK5-T NP_267536.1 prophage pi3 protein 06; similar to Orf95 of Lactococcus lactis phage BK5-T NP_267537.1 similar to Orf47 of bacteriophage r1t NP_267538.1 similar to Orf75 of Lactococcus lactis phage BK5-T NP_267539.1 similar to Orf1904 of Lactococcus lactis phage BK5-T NP_267540.1 similar to Orf44 of Streptococcus thermophilus bacteriophage phi o1205 NP_267541.1 similar to gp373 of Streptococcus thermophilus bacteriophage sfi11 NP_267542.1 similar to Orf1904 of Lactococcus lactis phage BK5-T NP_267543.1 tail component; similar to tail component protein Orf17 of Streptococcus thermophilus bacteriophage DT1 NP_267544.1 similar to minor capsid protein of Lactobacillus temperate phage phi g1e NP_267545.1 tail component; similar to Orf14 encoding a tail component protein of Streptococcus thermophilus bacteriophage DT1 NP_267546.1 prophage pi3 protein 17; similar to major tail protein of Streptococcus thermophilus bacteriophage DT1 NP_267547.1 tail component; similar to Orf12 encoding a tail component protein of Streptococcus thermophilus bacteriophage DT1 NP_267548.1 tail component; similar to 18K protein of Leuconostoc oenos phage L10 NP_267549.1 prophage pi3 protein 20; similar to head-tail joining protein of Streptococcus thermophilus bacteriophage DT1 NP_267550.1 similar to a hypothetical protein of Lactococcus lactis phage BK5-T NP_267551.1 prophage pi3 protein 22; similar to major head protein precursor of Streptococcus thermophilus bacteriophage Sfi21 NP_267552.1 prophage pi3 protein 23 NP_267553.1 similar to orf387 gp of Streptococcus thermophilus bacteriophage Sfi19 NP_267554.1 prophage pi3 protein 25; similar to head-tail joining protein of Streptococcus thermophilus bacteriophage DT1 NP_267555.1 prophage pi3 protein 26; similar to terminase large subunit of Streptococcus thermophilus bacteriophage Sfi21 NP_267556.1 prophage pi3 protein 27; similar to terminase small subunit of Streptococcus thermophilus bacteriophage Sfi21 NP_267557.1 similar to orf170 of Streptococcus thermophilus bacteriophage Sfi19 NP_267559.1 similar to a hypothetical protein of Lactococcus lactis accession number Y11901) NP_835319.1 similar to bacteriophage bIL286 Orf34 NP_267561.1 similar to orfX of bacteriophage 712 accession number AF087814 NP_835321.1 similar to bacteriophage bIL309 Orf27 NP_267562.1 similar to Orf29 of the Lactococcus lactis lytic bacteriophage sk1 NP_267563.1 similar to Orf21 of bacteriophage r1t NP_267564.1 prophage pi3 protein 35; de novo synthesis of thymidylate; similar to dUTPase of bacteriophage r1t NP_267566.1 similar to Orf19 of bacteriophage r1t NP_267567.1 similar to hypothetical protein 2 of bacteriophage T5 NP_267569.1 similar to Orf18 of bacteriophage r1t NP_267570.1 similar to Orf17 of bacteriophage r1t NP_267572.1 similar to Orf16 of bacteriophage r1t NP_267573.1 similar to Orf15 of bacteriophage r1t NP_267575.1 prophage pi3 protein 46; similar to the orf12 of the phage r1t; similar to DnaC of Escherichia coli or DnaI of Bacillus subtilis, which are required for chromosomal replication NP_267576.1 prophage pi3 protein 47; similar to Rep2009 of bacteriophage Tuc2009 NP_267577.1 prophage pi3 protein 48 NP_267579.1 similar to Orf10 of bacteriophage TP901-1 NP_267580.1 similar to Orf71 of Lactococcus bacteriophage phi31 NP_267581.1 similar to Orf10 of bacteriophage Tuc2009 NP_267582.1 similar to Orf113 of Lactococcus lactis phage BK5-T NP_267584.1 prophage pi3 protein 55; similar to P1-antirepressor homolog of Streptococcus thermophilus bacteriophage TP-J34 NP_267585.1 prophage pi3 protein 56; similar to cro-like repressor of Streptococcus thermophilus bacteriophage Sfi21 NP_267586.1 prophage pi3 protein 57; similar to repressor of Lactobacillus casei bacteriophage A2 NP_267589.1 prophage pi3 protein 60 NP_267590.1 similar to YlxM of Bacillus subtilis NP_267591.1 evidence experimental PMID:10708382; two-component systems NP_267592.1 evidence experimental PMID:9172368; two-component systems NP_835323.1 similar to Lactococcus lactis TcsBorf2; in the same operon as lrrB and kinB NP_267593.1 GntR-family regulator; probably ranscriptional regulator of acetyl-CoA synthesis (by the vicinity of corresponding genes) NP_267594.1 membranes, lipoproteins, and porins; attached to membrane by a lipid anchor; BMP family of lipoproteins NP_267595.1 salvage of nucleosides and nucleotides NP_267596.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_267598.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway NP_267599.1 SAM-dependent methyltransferase, evidenced by COGnitor NP_267600.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis NP_267602.1 transort and binding protein, cations NP_267603.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000 NP_267605.1 belongs to TetR/AcrR family NP_267607.1 evidence experimental PMID:10515910; transport and binding protein; amino acids, peptides and amines. involved in osmoprotection. Permease and substrate binding functions are in the same protein NP_267608.1 evidence experimental PMID:10515910; transport and binding protein; amino acids, peptides and amines. involved in osmoprotection NP_267609.1 GntR-family regulators; similar to fatty acid responsive regulator of Escherichia coli; probably an osmotic shock responce regulator from vicinity of corresponding genes NP_267610.1 surface polysaccharides, lipopolysaccharides and antigens NP_267611.1 surface polysaccharides, lipopolysaccharides and antigens NP_267615.1 energy metabolism, sugars NP_267616.1 transport and binding protein; PTS system NP_267617.1 evidence experimental PMID:8083160; BglG-family regulator NP_267618.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_267619.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_267622.1 evidence experimental PMID:1400208; aromatic amino-acid family NP_267623.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_267624.2 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_267625.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity NP_267626.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_267628.1 MarR-family regulator; N-terminal part similar to the MarR family of transcription regulators; C-terminal part similar to NAD(P)H nitroreductases NP_267629.1 SAM-dependent methyltransferase, evidenced by COGnitor NP_267632.1 general regulatory function NP_267635.1 MerR family of transcription regulators NP_267636.2 aerobic energy metabolism; short-chain dehydrogenase, evidenced by COGnitor NP_267637.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_267638.1 MarR-family regulator NP_267639.1 transport and binding protein, cations; similar to several magnesium and cobalt transporters NP_267641.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267642.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_267643.1 energy metabolism, sugars; similar to the sacK encoded fructokinase of Lactococcus lactis cremoris NZ9800 NP_267644.1 energy metabolism, sugars; similar to different sugar kinases NP_267645.1 energy metabolism, sugars; cellulose degradation pathway NP_267649.1 degradation of polysaccharides NP_267650.1 degradation of polysaccharides; similar to lacto-N-biosidase precursor of Streptomyces sp, the enzyme, which releases lacto-N-biose from oligosaccharides NP_267651.1 transport and binding protein, carbohydrates; organic alcohols and acids; attached to the membrance by a lipid anchor NP_267652.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267653.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267654.1 similar to different alpha-mannosidases NP_267656.1 LacI-family regulators; regulator of a polysacharide utilization operon. Highest similarity to L-arabinose utilization regulators from bacilli NP_267657.1 sugars; similar to alpha-1,2-mannosidase of Bacillus sp. M-90 NP_267659.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267660.1 sugars; acetyltransferase in xylose utilization operon NP_267661.1 sugars; intracellular xylan-degrading enzyme NP_267662.2 transport and binding protein, carbohydrates; organic alcohols and acids; xylose utilization; sodium:galactosidase symporter family NP_267663.1 sugars; xylose utilization; may act on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose NP_267664.1 sugars; xylose utilization NP_267665.1 catalyzes the interconversion of D-xylose to D-xylulose NP_267666.1 AraC-family regulators NP_267667.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_267668.1 evidence experimental PMID:9797284; catalytic subunit; sixth step in de novo purine biosynthesis NP_267669.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_267670.1 TerR/AcrR family NP_267671.1 transposon related function; belongs to the IS30 family of transposase NP_267672.1 transport and binding protein; multidrug resistance; similar to many multidrug resistance transporters NP_267673.1 similar to a hypothetical protein YfnB of Bacillus subtilis NP_267674.1 involved in de novo purine biosynthesis NP_267675.1 purine biosynthesis or salvage NP_267676.1 aerobic energy metabolism; similar to many reductases involved in flavonoid metabolism in plants; nucleoside-diphosphate-sugar epimerase, evidenced by COGnitor NP_267677.1 general regulatory function NP_267678.1 transport and binding protein NP_267679.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate NP_267680.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_267681.1 evidence experimental PMID:10094684; adaptations and atypical conditions; ATPase subunit of intracellular ATP-dependent protease NP_267683.1 aerobic energy metabolism; similar to NADH dehydrogenase of Aquifex aeolicus NP_267684.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_267685.1 aerobic energy metabolism; similar to many hypothetical oxidoreductases NP_267686.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_267687.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_267688.1 similar to YexA of Bacillus subtilis NP_267689.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_267690.1 similar to TM1010 of Thermotoga maritima NP_267692.1 similar to C-terminal part of several 4-carboxymuconolactone decarboxylases NP_267694.1 aerobic energy metabolism NP_267695.1 transport and binding protein; multidrug resistance; similar to several multidrug resistance proteins NP_267696.1 MarR-family regulators NP_267697.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_267700.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_267701.1 transposon related function; similar to orf1 of IS981 NP_267704.1 similar to YcdJ and YigE NP_267705.1 aerobic energy metabolism; similar to several alcohol dehydrogenases NP_267708.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group NP_267709.1 translation protein modification; involved in posttranslational protein modification NP_267710.1 aerobic energy metabolism NP_267711.1 transport and binding protein. contains two ATP binding domains NP_267712.1 aerobic energy metabolism; similar to several glycerol dehydrogenases NP_267714.1 degradation of proteins, peptides, and glycopeptides; similar to dipeptidase PepD of Lactobacillus helveticus NP_267715.2 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity NP_267717.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_267718.1 similar to DegV of Bacillus subtilis NP_267720.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_267721.1 Essential for efficient processing of 16S rRNA NP_267722.1 probably hydrolase, lysophospholipase, evidenced by COGnitor NP_267723.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_267725.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_267726.1 surface polysaccharides, lipopolysaccharides and antigens NP_267727.1 fatty acid and phospholipid metabolism NP_267728.1 fatty acid and phospholipid metabolism; potentially involved in some intermediate steps for the synthesis of a polyketide molecule which may be involved in secondary metabolism NP_267729.1 amino sugars; similar to glucosamine-6-P isomerase of Bacillus subtilis NP_267731.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_267732.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000 NP_267735.1 similar to leucine-rich proteins NP_267743.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_267744.1 cell division protein; required for initiation of cell division NP_267745.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_267746.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_267749.1 evidence experimental PMID:9172368; two-component systems NP_267750.1 evidence experimental PMID:10708382; two-component systems; involved in arginine metabolism regulation; essential for acid stress resistance development. NP_267752.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_267756.1 probably a phosphohydrolase, evidenced by COGnitor NP_267757.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_267758.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_267759.1 transport and binding protein; nucleosides, purines and pyrimidines NP_267760.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_267762.1 ArsR family NP_267763.1 transort and binding protein, cations NP_267764.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway NP_267765.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_267769.1 transport and binding protein; amino acids, peptides and amines NP_267771.1 polyamine biosynthesis; regulates polyamine concentraion by their degradation NP_267772.1 protein and peptide secretion; SRP family of GTP-binding proteins NP_267773.1 probably induced by the competence induction factor NP_267775.1 transort and binding protein, cations NP_267776.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_267777.1 Probably ADP-ribose pyrophosphatase or mutT, evidenced by COGnitor NP_267778.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde NP_267779.1 transport and binding protein, carbohydrates; organic alcohols and acids; similar to glycerol uptake facilitator GlpF of Bacillus subtilis; belongs to the transmembrane channel Mip family NP_267781.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_267782.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate NP_267783.1 Entner-Doudoroff pathway; glucuronate utilization pathway NP_267784.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism NP_267786.1 transport and binding protein, carbohydrates; organic alcohols and acids; transporter in glucuronate utilization pathway NP_267787.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate NP_267788.1 sugars; glucuronate utilization pathway NP_267789.1 probably regulates uronic acid metabolism NP_267790.1 transport and binding protein; multidrug resistance; belongs to the major facilitator family, also know as drug resistance translocase family NP_267791.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267792.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267793.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267794.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_267795.1 energy metabolism, sugars NP_267796.1 LacI-family regulators NP_267797.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_267798.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis NP_267801.1 DNA mismatch repair protein NP_267802.1 similar to YshB of Bacillus subtilis NP_267803.1 thioredoxin, glutaredoxin, and glutathione; cofactor FAD flavoprotein; pyridine nucleotide-disulfide oxidoreductase class-II NP_267804.1 evidence experimental PMID:9922238; LacI-family regulators NP_267805.1 degradation of proteins, peptides, and glycopeptides NP_267810.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_267812.1 cell division protein; required for chromosome segregation and septum formation; may be involved in peptidoglycan synthesis or modification NP_267815.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_267816.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_267817.1 aerobic energy metabolism NP_267819.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate NP_267825.1 similar to positive regulator GadR of Lactococcus lactis NP_267826.1 evidence experimental PMID:8366036; transmembrane protein NP_267827.1 required for arbutin uptake and metabolism NP_267828.1 similar to YtjA of Bacillus subtilis NP_267829.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_267830.1 two-component systems NP_267831.1 evidence experimental PMID:10708382; two-component systems; involved in oxidative stress resistance development NP_267832.1 LacI-family regulators NP_267833.1 central intermediary metabolism NP_267834.1 degradation of polysaccharides NP_267835.1 degradation of polysaccharides NP_267836.1 energy metabolism, sugars NP_267837.1 degradation of polysaccharides NP_267838.1 degradation of polysaccharides NP_267839.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267840.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267841.1 transport and binding protein, carbohydrates; organic alcohols and acids NP_267847.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_267848.1 transposon related function; orf1 of IS981 NP_835326.1 similar to internalin NP_267850.1 ArsR family of transcription regulators NP_267851.1 aerobic energy metabolism NP_267852.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_267853.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis NP_267854.1 transposon related function; belongs to the IS30 family of transposase NP_267855.1 transport and binding protein; amino acids, peptides and amines NP_267856.1 catalyzes the formation of putrescine from carbamoyl-putrescine during agmatine degradation NP_267857.1 two-component systems NP_267858.1 LytR family; probably a signal transducer for the regulator LrrH NP_267859.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_267861.1 energy metabolism; electron transport; iron sulfur protein that transfers electrons in a variety of metabolic reactions NP_267862.1 transport and binding protein; PTS system NP_267863.1 transport and binding protein; PTS system NP_267864.1 transport and binding protein; PTS system NP_267868.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_267871.1 general regulatory function NP_267872.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_267873.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_267874.1 transport and binding protein, anions NP_267875.1 transport and binding protein, anions NP_267876.1 transport and binding protein, anions; identical to lipoprotein Nlp1 of Lactococcus lactis NP_267877.1 transport and binding protein, anions; similar to lipoprotein Nlp1 from Lactococcus lactis NP_267878.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_267880.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_267882.1 SAM-dependent methyltransferase, evidenced by COGnitor NP_267883.1 evidence experimental PMID:7798200; degradation of proteins, peptides, and glycopeptides; hydrolyzes peptides containing between 7 and 17 amino acids with a rather wide specificity; peptidase family M3 (zinc metalloprotease) NP_267884.1 competence protein; transformation; similar to CoiA protein in Streptococcus pneumoniae needed for competence development NP_267889.1 aerobic energy metabolism; similar to different oxido-reductases NP_267890.1 aerobic energy metabolism; similar to several iron-binding oxidase subunit proteins NP_267892.1 transport and binding protein; similar to several permeases NP_267895.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_267897.1 glycolysis; similar to phosphoglycerate mutases or 6-phosphofructo-2-kinases NP_267898.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis NP_267899.1 evidence experimental PMID:7823907; aromatic amino-acid family NP_267900.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_267901.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_267902.1 two-component systems NP_267903.1 two-component systems NP_267905.1 transport and binding protein; probably the same function as YtsD of Bacillus subtilis NP_267906.1 transport and binding protein NP_267908.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_267910.1 similar to YktB of Bacillus subtilis NP_267912.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_267913.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate NP_267915.1 transport and binding protein; amino acids, peptides and amines; N-terimal 500 aa is substrate binding, and the C-terminal is permease domain NP_267916.1 transport and binding protein; amino acids, peptides and amines NP_267919.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_267920.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_267921.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_267922.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_267923.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_267924.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_267925.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_267926.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 NP_267928.1 fatty acid and phospholipid metabolism NP_267929.1 competence protein; transformation; required for internalisation of transforming DNA, but is dispensable for DNA binding. NP_267930.1 competence protein; DNA receptor during transformation; membrane protein NP_267931.1 transport and binding protein NP_267932.1 transport and binding protein NP_267934.1 drug and analog sensitivity NP_267935.1 transort and binding protein, cations NP_267936.1 transcription regulator; in Bacillus subtilis production of several extracellular degradative enzymes at the transcription level, probably by interfering with DegS and DegU, which are required from this effect NP_267937.1 bifunctional protein; biotin-(acetyl-CoA carboxylase) ligase NP_267940.1 fatty acid and phospholipid metabolism NP_267943.1 fatty acid and phospholipid metabolism NP_267944.1 energy metabolism; fermentation; similar to 2-nitropropane dioxygenase NP_267946.2 energy metabolism; electron transport; involved in Fe-S cluster formation NP_267948.1 selenocysteine lyase, evidenced by COGnitor; similar to YurW of Bacillus subtilis NP_267950.1 transport and binding protein NP_267951.1 surface polysaccharides, lipopolysaccharides and antigens; similar to TagO of Bacillus subtilis involved in teichoic acid linkage unit synthesis NP_267952.1 similar to MecA protein from Bacillus NP_267953.1 transport and binding protein; amino acids, peptides and amines NP_267954.1 transport and binding protein; amino acids, peptides and amines NP_267955.1 similar to YtlR of Bacillus subtilis NP_267956.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_267957.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_267958.1 CodY family of transcription regulators NP_267959.1 similar to EpsR of the epsRXABCDEFGHIJKL operon of Lactococcus lactis plasmid pNZ4000 NP_267960.1 evidence experimental PMID:8244921; degradation of proteins, peptides, and glycopeptides NP_267963.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_267964.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs NP_267965.1 ATP-dependent DNA helicase; transformation; probably a part of the competence regulon NP_267966.2 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_267967.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_267969.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_267971.1 transport and binding protein NP_267972.1 transport and binding protein NP_267973.1 probably acyltransferase, evidenced by COGnitor NP_267974.1 similar to HI0220.2 of Haemophilus influenzae Rd NP_267975.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_267977.1 riboflavin and cobalamin; similar to phosphoglycerate mutases NP_267978.1 similar to YazA of Bacillus subtilis NP_267979.1 transport and binding protein; amino acids, peptides and amines; similar to many amino acid permeases NP_267980.1 aerobic energy metabolism NP_267981.1 similar to YloS protein of Bacillus subtilis NP_267985.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_267987.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_267989.1 ATP-dependent helicase; DNA replication, restriction, modification, recombination, and repair; helicase involved in DNA repair and perhaps also replication NP_267991.1 transport and binding protein; similar to CBS domain-containing proteins NP_267992.1 drug and analog sensitivity NP_267993.1 translation; protein modification NP_267994.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines NP_267995.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines NP_267996.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines NP_267997.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines NP_267998.1 evidence experimental PMID:8586224; transport and binding protein; amino acids, peptides and amines NP_267999.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_268000.1 ribosomal proteins; synthesis and modification; L35P family of ribosomal proteins NP_268001.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_268004.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_268007.1 similar to YazC of Bacillus subtilis NP_268008.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_268010.1 serine family NP_268012.1 degradation of RNA NP_268014.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_268016.1 energy metabolism, electron transport; similar to YrvO of Bacillus subtilis; cysteine sulfinate desulfinase/cysteine desulfurase, evidenced by COGnitor NP_268018.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_268020.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme NP_268021.1 similar to cell division protein DivIVA of Bacillus subtilis NP_268022.1 similar to YlmH of Bacillus subtilis NP_268023.1 similar to YlmG of Bacillus subtilis NP_268024.1 similar to YlmF of Bacillus subtilis NP_268025.1 similar to YlmE of Bacillus subtilis NP_268026.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_268027.1 cell division protein NP_268028.1 similar to YitS protein from Bacillus subtilis. NP_268029.1 tRNA modification; methylates guanosine-18 in various tRNAS NP_268030.2 similar to oxidoreductases NP_268031.1 aerobic energy metabolism NP_268032.1 transport and binding protein NP_268033.1 LysR-family regulator NP_268034.1 MerR family of transcription regulators NP_268035.1 evidence experimental PMID:8439160; degradation of proteins, peptides, and glycopeptides NP_268037.2 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine NP_268040.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_268041.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate NP_268042.1 transposon related function; belongs to the IS30 family of transposase NP_268043.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_268044.1 translation; protein modification NP_268045.2 translation; protein modification NP_268046.1 RNA synthesis, modification, and DNA transcription; similar to RNA-binding Sun protein of Bacillus subtilis, predicted to be rRNA methylase NP_268047.1 similar to a 20 kD protein from sucrose-nisin transposon Tn5306 YP_008998704.1 membrane protein NP_268050.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_268052.1 similar to ADP-ribose pyrophosphatase or MutT protein of Bacillus subtilis NP_268054.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_268055.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_268056.1 Essential for recycling GMP and indirectly, cGMP NP_268057.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_835328.1 simialr to carboxy terminus of S-adenosylmethionine synthetase NP_268059.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_268060.1 COG says Biotin-(acetyl-CoA carboxylase) ligase NP_268061.1 similar to YvlC protein of Bacillus subtilis; probably stress-responsive transcription regulator, evidenced by COGnitor NP_268062.1 similar to YvlC protein of Bacillus subtilis; probably stress-responsive transcription regulator, evidenced by COGnitor NP_268063.1 similar to YvlB of Bacillus subtilis NP_268064.1 cell envelope, murein sacculus and peptidoglycan; muramidase needed for cell separation and responsible for autolysis NP_268065.1 transposon related function; belongs to the IS30 family of transposase NP_268066.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_268068.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_268071.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_268072.1 transort and binding protein, cations NP_268073.1 energy metabolism, amino acids and amines; belongs to class-II of pyridoxal-phosphate-dependent aminotransferases; MALY/PATB subfamily; probably methionine specific aminotransferase NP_268074.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine NP_268075.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis NP_268079.1 similar to CMP-binding-factor 1 of S.aureus NP_268081.1 pentose phosphate pathway NP_268083.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity NP_268084.2 similar to extracellular protein Exp1 precursor NP_268085.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_268086.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_268087.1 energy metabolism, amino acids and amines; specificity of the enzyme is not clearly defined NP_268088.1 transposon related function; belongs to the IS30 family of transposase NP_835329.1 similar to bacteriophage bIL311 Orf16 NP_268094.1 transposon related function; belongs to the IS30 family of transposase NP_268100.1 similar to a bacteriophage resistance protein from Lactococcus lactis NP_835330.1 similar to bacteriophage bIL311 Orf7 NP_835331.1 similar to bacteriophage bIL311 Orf6 NP_835332.1 similar to bacteriophage bIL311 Orf5 NP_835333.1 similar to bacteriophage bIL311 Orf4 NP_268103.1 transcription regulator; similar to cro-like repressor of bacteriophage phig1e NP_268105.1 prophage ps3 protein 16 NP_268106.1 probably transcription regulator, evidenced by COGnitor NP_268107.1 degradation of polysaccharides; hydrolysis of the beta-1,4 linkages of N-acetyl-D-glucosamine polymers of chitin NP_268108.1 central intermediary metabolism; degradation of polysaccharides; probably a secreted chitinase NP_268109.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_268110.1 transport and binding protein NP_835334.1 similar to bacteriophage bIL310 Orf3 NP_268116.2 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_268117.1 dihydrofolate reductase, evidenced by COGnitor NP_268118.1 aerobic energy metabolism NP_268119.1 similar to YpjC protein of Bacillus subtilis NP_268120.1 similar to YpjC protein of Bacillus subtilis NP_268121.1 similar to YitT protein of Bacillus subtilis NP_268122.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_268124.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_268125.1 similar to positive regulator GadR of Lactococcus lactis NP_268127.1 membranes, lipoproteins, and porins; catalyzes the committed step to the synthesis of the acidic phospholipids; integral membrance protein NP_268129.1 degradation of proteins, peptides, and glycopeptides; similar to different proteases NP_268130.1 degradation of proteins, peptides, and glycopeptides; similar to several proteases NP_268132.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_268133.1 central intermediary metabolism; third step in the catabolism of protocatechuate to succinate and acetyl-CoA in the beta-ketoadipate pathway NP_268134.1 MerR family of transcription regulators NP_268136.1 galactose metabolism NP_268137.2 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon NP_268139.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism NP_268140.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism NP_268141.1 galactose metabolism NP_268142.1 RpiR family of transcription regulators NP_268143.1 aerobic energy metabolism NP_268144.1 NadR family of transcription regulators NP_268145.1 aerobic energy metabolism NP_268146.1 degradation of proteins, peptides, and glycopeptides NP_268148.1 degradation of proteins, peptides, and glycopeptides NP_268150.1 probably a SAM-dependent RNA methyltransferase, evidenced by COGnitor NP_268152.1 transport and binding protein; similar to EcsB of Bacillus subtilis involved in the control of levels of exoamylase and other exoenzymes NP_268153.1 transport and binding protein; similar to EcsA of Bacillus subtilis controlling levels of exoamylase and other exoenzymes NP_268157.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_268158.1 binds directly to 23S ribosomal RNA NP_268159.1 transport and binding protein, cations; similar to cadmium resistance protein of Lactococcus lactis NP_268160.1 CRP/FNR family of transcription regulators NP_268161.1 transposon related function; belongs to the IS30 family of transposase NP_268162.1 similar to YozE of Bacillus subtilis NP_268163.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_268164.1 similar to YitL protein of Bacillus subtilis NP_268166.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_268167.1 Catalyzes the phosphorylation of UMP to UDP NP_268169.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_268170.1 fermentation; first of two steps in the conversion of acetate to acetyl-CoA NP_268172.1 GTP-binding protein; BipA NP_268175.1 transport and binding protein NP_268180.1 energy metabolism, sugars NP_268182.1 adaptations and atypical conditions; known in other bacteria also as starvation-inducible DNA-binding protein Dps NP_268183.1 evidence experimental PMID:8389385; transposon related function; related to a family of IS elements that includes IS2, IS3, IS150, IS600, IS629, IS861, IS904 and ISL1 NP_268184.1 transposon related function; orf1 of IS981 NP_268185.1 transformation; required for processind and membrane assembling of ComG proteins. NP_268186.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_268188.1 transport and binding protein; amino acids, peptides and amines NP_268189.1 associated with arginine deiminase pathway genes; probably functions in arginine catabolism NP_268190.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_268191.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_268192.1 transport and binding protein; amino acids, peptides and amines NP_268193.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway NP_268194.1 catalyzes the degradation of arginine to citruline and ammonia NP_268195.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_268196.1 regulator of arginine degradation pathway NP_268197.2 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_268199.1 DNA replication, restriction, modification, recombination, and repair NP_268201.1 aerobic energy metabolism NP_268205.1 transport and binding protein, carbohydrates; organic alcohols and acids; similar to glycerol uptake facilitator GlpF of Bacillus subtilis; transmembrance channel MIP family NP_268206.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue NP_268208.1 transport and binding protein; amino acids, peptides and amines NP_268209.1 pyridine nucleotides; may be mercuric reductase NP_268210.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_268211.1 probably amidase, evidenced by COGnitor NP_268219.1 transposon related function; belongs to the IS30 family of transposase NP_268221.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_268224.1 is a component of the macrolide binding site in the peptidyl transferase center NP_268225.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_268226.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_268227.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_268228.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_268229.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_268230.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_268231.1 trasposon related functions NP_268232.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_268233.1 transposon related function NP_268234.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_268235.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_268236.1 late assembly protein NP_268237.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_268238.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_268239.1 binds 5S rRNA along with protein L5 and L25 NP_268240.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_268241.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_268243.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif NP_268244.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_268245.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_268246.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_268247.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_268248.1 one of the stabilizing components for the large ribosomal subunit NP_268249.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_268250.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_268251.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_268252.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_268253.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_268254.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_268255.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_268256.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_268257.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_268258.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_268259.1 similar to MATE efflux family transporter proteins NP_268260.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_268261.1 Modulates Rho-dependent transcription termination NP_268262.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_268263.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif NP_268265.1 murein sacculus and peptidoglycan NP_268268.1 energy metabolism, electron transport NP_268270.1 transort and binding protein, cations NP_268271.1 transort and binding protein, cations NP_268272.1 transort and binding protein, cations NP_268273.1 MarR-family regulators; similar to AdcR repressor of adc locus, affecting competence in Streptococcus pneumoniae NP_268277.1 competence protein; transformation; required for the assembly of the competence membrane machinery NP_268278.1 competence protein; transformation; required for the assembly of the competence membrane machinery NP_268279.1 competence protein; transformation; required for the assembly of the competence membrane machinery; PULE/OUTE/EXEE/XPSE/XCPR family NP_268280.1 competence protein; transformation required for the assembly of the competence membrane machinery; PULE/OUTE/EXEE/XPSE/XCPR family NP_268281.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity NP_268283.1 aerobic energy metabolism NP_268284.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_268286.1 membranes, lipoproteins, and porins; integral membrance protein NP_268287.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_268291.2 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_268292.1 transposon related function; belongs to the IS30 family of transposase NP_268293.1 evidence experimental PMID:10712686; degradation of proteins, peptides, and glycopeptides. this protease is responsible for degradation of secreted hybrid proteins NP_268294.1 surface polysaccharides, lipopolysaccharides and antigens; similar to CpoA of Streptococcus pneumoniae, supposed to be involved in lipopolysaccharide core biosynthesis NP_268295.1 surface polysaccharides, lipopolysaccharides and antigens NP_268299.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_268301.1 LacI-family regulators; probably the N-terminal part of rliD, interrupted by transposon insertion NP_268302.1 evidence experimental PMID:1328163; transposon related function; IS3/IS150/IS904 family transposase NP_268303.1 transposon related function NP_268304.1 evidence experimental PMID:1328163; transposon related function. IS3/IS150/IS904 family transposase NP_268305.1 transposon related function NP_268306.1 LacI-family regulators; probably the C-terminal part of rliD, interrupted by transposon insertion NP_268307.1 competence regulator; transformation; similar to ComX1 from Streptococcus pneumoniae. Probably a sigma factor, involved in regulation of competence NP_268308.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation NP_268309.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_268310.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_268311.1 similar to YkbG of Bacillus subtilis NP_268312.1 evidence experimental PMID:9620952; energy metabolism; fermentation NP_268317.1 general regulatory function NP_268319.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_268320.1 N6-adenine-specific methylase, evidenced by COGnitor; similar to type II DNA modification methyltransferase NP_268321.1 transport and binding protein; multidrug resistance; similar to the integral membrane protein LmrP from Lactococcus lactis NP_268322.1 integral membrane protein; transport and binding protein; multidrug resistance; there is no connection with the lmrA gene NP_268323.1 RNA synthesis, modification, and DNA transcription NP_268325.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_268330.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_268339.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_268340.1 transposon related function; belongs to the IS30 family of transposase NP_268341.1 energy metabolism, sugars NP_268342.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate NP_268343.1 RpiR family of transcription regulators; probably involved in gnt operon regulation NP_268345.1 probably a phosphohydrolase, evidenced by COGnitor NP_268346.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_268347.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_268348.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_268349.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_268350.1 transport and binding protein; amino acids, peptides and amines; there is another lysine specific permease LysQ NP_268351.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_268354.1 similar to N-terminal part of chorismate mutases from several species NP_268357.1 glutamate family NP_268358.2 MerR family of transcription regulators NP_268359.1 protein modification NP_268360.1 transport and binding protein NP_268361.1 transport and binding protein NP_268362.1 similar to a positive regulator GadR from Lactococcus lactis NP_268363.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_268364.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_268365.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_268367.1 This protein performs the mismatch recognition step during the DNA repair process NP_268370.1 PBSX(XRE) family of transcription regulators NP_268372.1 energy metabolism, amino acids and amines NP_268375.1 transport and binding protein NP_268377.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_268381.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_268383.1 evidence experimental PMID:1907199; murein sacculus and peptidoglycan; provides D-aspartate, which plays a role of cross-bridge during peptidoglycan network formation NP_268384.1 probably carbamoylphosphate synthase large subunit, evidenced by COGnitor NP_268385.1 aspartate family NP_268386.1 evidence experimental PMID:2123812; secreted 45 kDa precursor NP_268387.1 murein sacculus and peptidoglycan; involved in formation of the shape of the cell; may contribute to regulation of formation of penicillin-binding proteins NP_268388.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_268390.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_268391.1 CRP/FNR family of transcription regulators NP_268392.1 transport and binding protein; multidrug resistance; similar to quinolon resistance protein NorA from difference species NP_268395.1 similar to activator of (R)-2-hydroxyglutaryl-CoA dehydratase of Acidaminococcus fermentans NP_268396.1 belongs to TetR/AcrR family NP_268397.1 RNA synthesis, modification, and DNA transcription; formation of pseudouridine from uracil-516 in 16S rRNA; family 1 of pseudouridine synthases and rluC NP_268398.1 similar to P50 adhesin of Mycoplasma hominisadhesins; probably a surface protein NP_268399.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_268401.1 catalyzes branch migration in Holliday junction intermediates NP_268402.1 transport and binding protein, anions NP_268403.1 glycolysis NP_268405.1 transort and binding protein; cations NP_268406.1 general regulatory function NP_268407.1 aerobic energy metabolism; similar to different oxidoreductases NP_268409.1 transport and binding protein NP_268410.1 forms a direct contact with the tRNA during translation NP_268411.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_268413.1 transport and binding protein NP_268414.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_268415.1 protein and peptide secretion NP_268416.1 general regulatory function NP_268417.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_268418.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_268419.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_268420.1 murein sacculus and peptidoglycan; final stages in peptidoglycan synthesis; peptidase family S11, also know as D-alanyl-D-alanine carboxypeptidase 1 family NP_268421.1 transport and binding protein; similar to several membrane proteins NP_268422.1 similar to YtqB of Bacillus subtilis; probably SAM-dependent methyltransferase, evidence by COGnitor