-- dump date 20140619_125613 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272623000001 UNKNOWN FEATURE KEY Comment; REFSEQ gene predictions performed by GeneMark 2.4/GeneMark.hmm 2.0 with comparison to original submitter provided annotation. tRNA predictions performed by tRNAscan-SE v.1.23. rRNA predictions performed by BLAST 272623000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272623000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000004 Walker A motif; other site 272623000005 ATP binding site [chemical binding]; other site 272623000006 arginine finger; other site 272623000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272623000008 DnaA box-binding interface [nucleotide binding]; other site 272623000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272623000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 272623000011 putative DNA binding surface [nucleotide binding]; other site 272623000012 dimer interface [polypeptide binding]; other site 272623000013 beta-clamp/clamp loader binding surface; other site 272623000014 beta-clamp/translesion DNA polymerase binding surface; other site 272623000015 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 272623000016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272623000017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272623000018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272623000019 Part of AAA domain; Region: AAA_19; pfam13245 272623000020 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 272623000021 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 272623000022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623000023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000024 non-specific DNA binding site [nucleotide binding]; other site 272623000025 salt bridge; other site 272623000026 sequence-specific DNA binding site [nucleotide binding]; other site 272623000027 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 272623000028 GTP-binding protein YchF; Reviewed; Region: PRK09601 272623000029 YchF GTPase; Region: YchF; cd01900 272623000030 G1 box; other site 272623000031 GTP/Mg2+ binding site [chemical binding]; other site 272623000032 Switch I region; other site 272623000033 G2 box; other site 272623000034 Switch II region; other site 272623000035 G3 box; other site 272623000036 G4 box; other site 272623000037 G5 box; other site 272623000038 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272623000039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000040 non-specific DNA binding site [nucleotide binding]; other site 272623000041 salt bridge; other site 272623000042 sequence-specific DNA binding site [nucleotide binding]; other site 272623000043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 272623000044 FtsX-like permease family; Region: FtsX; pfam02687 272623000045 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272623000046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623000047 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272623000048 Walker A/P-loop; other site 272623000049 ATP binding site [chemical binding]; other site 272623000050 Q-loop/lid; other site 272623000051 ABC transporter signature motif; other site 272623000052 Walker B; other site 272623000053 D-loop; other site 272623000054 H-loop/switch region; other site 272623000055 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272623000056 AAA domain; Region: AAA_17; cl19128 272623000057 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272623000058 putative active site [active] 272623000059 catalytic residue [active] 272623000060 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272623000061 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272623000062 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272623000063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623000064 ATP binding site [chemical binding]; other site 272623000065 putative Mg++ binding site [ion binding]; other site 272623000066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623000067 nucleotide binding region [chemical binding]; other site 272623000068 ATP-binding site [chemical binding]; other site 272623000069 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272623000070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623000071 RNA binding surface [nucleotide binding]; other site 272623000072 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272623000073 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623000074 RNA binding site [nucleotide binding]; other site 272623000075 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272623000076 SH3-like domain; Region: SH3_8; pfam13457 272623000077 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272623000078 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272623000079 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272623000080 Ligand Binding Site [chemical binding]; other site 272623000081 TilS substrate C-terminal domain; Region: TilS_C; smart00977 272623000082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623000083 active site 272623000084 FtsH Extracellular; Region: FtsH_ext; pfam06480 272623000085 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272623000086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000087 Walker A motif; other site 272623000088 ATP binding site [chemical binding]; other site 272623000089 Walker B motif; other site 272623000090 arginine finger; other site 272623000091 Peptidase family M41; Region: Peptidase_M41; pfam01434 272623000092 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272623000093 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272623000094 PRD domain; Region: PRD; pfam00874 272623000095 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 272623000096 active site 272623000097 P-loop; other site 272623000098 phosphorylation site [posttranslational modification] 272623000099 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272623000100 active site 272623000101 phosphorylation site [posttranslational modification] 272623000102 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272623000103 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272623000104 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272623000105 Bacteriophage bIL310 272623000106 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272623000107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272623000108 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623000109 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 272623000110 Phage associated DNA primase [General function prediction only]; Region: COG3378 272623000111 D5 N terminal like; Region: D5_N; smart00885 272623000112 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 272623000113 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 272623000114 polymerase nucleotide-binding site; other site 272623000115 DNA-binding residues [nucleotide binding]; DNA binding site 272623000116 nucleotide binding site [chemical binding]; other site 272623000117 primase nucleotide-binding site [nucleotide binding]; other site 272623000118 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 272623000119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623000120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000121 non-specific DNA binding site [nucleotide binding]; other site 272623000122 salt bridge; other site 272623000123 sequence-specific DNA binding site [nucleotide binding]; other site 272623000124 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623000125 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272623000126 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272623000127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623000128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000129 non-specific DNA binding site [nucleotide binding]; other site 272623000130 salt bridge; other site 272623000131 sequence-specific DNA binding site [nucleotide binding]; other site 272623000132 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623000133 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272623000134 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623000135 Int/Topo IB signature motif; other site 272623000136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272623000137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000138 Coenzyme A binding pocket [chemical binding]; other site 272623000139 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 272623000140 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272623000141 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272623000142 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272623000143 HTH-like domain; Region: HTH_21; pfam13276 272623000144 Integrase core domain; Region: rve; pfam00665 272623000145 Integrase core domain; Region: rve_3; pfam13683 272623000146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623000147 HTH-like domain; Region: HTH_21; pfam13276 272623000148 Integrase core domain; Region: rve; pfam00665 272623000149 Integrase core domain; Region: rve_3; pfam13683 272623000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000151 Transposase; Region: HTH_Tnp_1; pfam01527 272623000152 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272623000153 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272623000154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000155 Coenzyme A binding pocket [chemical binding]; other site 272623000156 aminotransferase A; Validated; Region: PRK07683 272623000157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623000158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000159 homodimer interface [polypeptide binding]; other site 272623000160 catalytic residue [active] 272623000161 Recombination protein O N terminal; Region: RecO_N; pfam11967 272623000162 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 272623000163 Recombination protein O C terminal; Region: RecO_C; pfam02565 272623000164 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272623000165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623000166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623000167 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623000168 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272623000169 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 272623000170 E3 interaction surface; other site 272623000171 lipoyl attachment site [posttranslational modification]; other site 272623000172 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272623000173 E3 interaction surface; other site 272623000174 lipoyl attachment site [posttranslational modification]; other site 272623000175 e3 binding domain; Region: E3_binding; pfam02817 272623000176 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272623000177 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272623000178 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272623000179 alpha subunit interface [polypeptide binding]; other site 272623000180 TPP binding site [chemical binding]; other site 272623000181 heterodimer interface [polypeptide binding]; other site 272623000182 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623000183 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272623000184 tetramer interface [polypeptide binding]; other site 272623000185 TPP-binding site [chemical binding]; other site 272623000186 heterodimer interface [polypeptide binding]; other site 272623000187 phosphorylation loop region [posttranslational modification] 272623000188 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272623000189 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272623000190 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272623000191 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272623000192 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272623000193 active site 272623000194 catalytic site [active] 272623000195 metal binding site [ion binding]; metal-binding site 272623000196 dimer interface [polypeptide binding]; other site 272623000197 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272623000198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623000199 Zn2+ binding site [ion binding]; other site 272623000200 Mg2+ binding site [ion binding]; other site 272623000201 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272623000202 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272623000203 active site 272623000204 HIGH motif; other site 272623000205 dimer interface [polypeptide binding]; other site 272623000206 KMSKS motif; other site 272623000207 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272623000208 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623000209 putative phosphate acyltransferase; Provisional; Region: PRK05331 272623000210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623000211 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623000212 active site 272623000213 motif I; other site 272623000214 motif II; other site 272623000215 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623000216 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272623000217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623000218 ABC transporter; Region: ABC_tran_2; pfam12848 272623000219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623000220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623000221 homodimer interface [polypeptide binding]; other site 272623000222 substrate-cofactor binding pocket; other site 272623000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000224 catalytic residue [active] 272623000225 short chain dehydrogenase; Validated; Region: PRK06182 272623000226 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623000227 NADP binding site [chemical binding]; other site 272623000228 active site 272623000229 steroid binding site; other site 272623000230 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623000231 Ligand Binding Site [chemical binding]; other site 272623000232 Uncharacterized protein conserved in Streptococci; Region: SP_1775_like; cl19119 272623000233 oligomer interface [polypeptide binding]; other site 272623000234 putative ligand binding site [chemical binding]; other site 272623000235 Predicted esterase [General function prediction only]; Region: COG0400 272623000236 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272623000237 Zn binding site [ion binding]; other site 272623000238 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272623000239 Zn binding site [ion binding]; other site 272623000240 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272623000241 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272623000242 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 272623000243 putative active site [active] 272623000244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623000245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623000246 Walker A/P-loop; other site 272623000247 ATP binding site [chemical binding]; other site 272623000248 Q-loop/lid; other site 272623000249 ABC transporter signature motif; other site 272623000250 Walker B; other site 272623000251 D-loop; other site 272623000252 H-loop/switch region; other site 272623000253 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272623000254 HlyD family secretion protein; Region: HlyD_3; pfam13437 272623000255 CAAX protease self-immunity; Region: Abi; pfam02517 272623000256 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272623000257 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272623000258 putative transposase OrfB; Reviewed; Region: PHA02517 272623000259 HTH-like domain; Region: HTH_21; pfam13276 272623000260 Integrase core domain; Region: rve; pfam00665 272623000261 Integrase core domain; Region: rve_3; pfam13683 272623000262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000263 Transposase; Region: HTH_Tnp_1; pfam01527 272623000264 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272623000265 Integrase core domain; Region: rve; pfam00665 272623000266 DDE domain; Region: DDE_Tnp_IS240; pfam13610 272623000267 Integrase core domain; Region: rve_3; pfam13683 272623000268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000269 Transposase; Region: HTH_Tnp_1; pfam01527 272623000270 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 272623000271 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272623000272 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272623000273 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272623000274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623000275 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272623000276 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272623000277 ParB-like nuclease domain; Region: ParBc; pfam02195 272623000278 KorB domain; Region: KorB; pfam08535 272623000279 recombination factor protein RarA; Reviewed; Region: PRK13342 272623000280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000281 Walker A motif; other site 272623000282 ATP binding site [chemical binding]; other site 272623000283 Walker B motif; other site 272623000284 arginine finger; other site 272623000285 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272623000286 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272623000287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000288 Coenzyme A binding pocket [chemical binding]; other site 272623000289 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 272623000290 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623000291 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623000292 ABC transporter; Region: ABC_tran_2; pfam12848 272623000293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623000294 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272623000295 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272623000296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623000297 S-adenosylmethionine binding site [chemical binding]; other site 272623000298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272623000299 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272623000300 putative active site [active] 272623000301 putative metal binding site [ion binding]; other site 272623000302 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272623000303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623000304 Zn2+ binding site [ion binding]; other site 272623000305 Mg2+ binding site [ion binding]; other site 272623000306 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623000307 synthetase active site [active] 272623000308 NTP binding site [chemical binding]; other site 272623000309 metal binding site [ion binding]; metal-binding site 272623000310 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272623000311 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272623000312 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272623000313 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272623000314 Ligand binding site; other site 272623000315 Putative Catalytic site; other site 272623000316 DXD motif; other site 272623000317 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272623000318 putative active site [active] 272623000319 dimerization interface [polypeptide binding]; other site 272623000320 putative tRNAtyr binding site [nucleotide binding]; other site 272623000321 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623000322 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272623000323 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 272623000324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623000325 amino acid transporter; Region: 2A0306; TIGR00909 272623000326 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272623000327 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272623000328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272623000329 putative acyl-acceptor binding pocket; other site 272623000330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623000331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623000332 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272623000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272623000334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272623000335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623000336 nucleotide binding region [chemical binding]; other site 272623000337 ATP-binding site [chemical binding]; other site 272623000338 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272623000339 SEC-C motif; Region: SEC-C; pfam02810 272623000340 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 272623000341 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272623000342 dimerization domain swap beta strand [polypeptide binding]; other site 272623000343 regulatory protein interface [polypeptide binding]; other site 272623000344 active site 272623000345 regulatory phosphorylation site [posttranslational modification]; other site 272623000346 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272623000347 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272623000348 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272623000349 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272623000350 hypothetical protein; Validated; Region: PRK00153 272623000351 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272623000352 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623000353 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272623000354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623000356 putative substrate translocation pore; other site 272623000357 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272623000358 ANP binding site [chemical binding]; other site 272623000359 Substrate Binding Site II [chemical binding]; other site 272623000360 Substrate Binding Site I [chemical binding]; other site 272623000361 argininosuccinate lyase; Provisional; Region: PRK00855 272623000362 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272623000363 active sites [active] 272623000364 tetramer interface [polypeptide binding]; other site 272623000365 drug efflux system protein MdtG; Provisional; Region: PRK09874 272623000366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000367 putative substrate translocation pore; other site 272623000368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623000370 WHG domain; Region: WHG; pfam13305 272623000371 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272623000372 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272623000373 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272623000374 Jag N-terminus; Region: Jag_N; pfam14804 272623000375 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272623000376 G-X-X-G motif; other site 272623000377 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272623000378 RxxxH motif; other site 272623000379 Ribosomal protein L34 [Translation, ribosomal structure and biogenesis]; Region: RpmH; COG0230 272623000380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623000381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000382 non-specific DNA binding site [nucleotide binding]; other site 272623000383 salt bridge; other site 272623000384 sequence-specific DNA binding site [nucleotide binding]; other site 272623000385 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 272623000386 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272623000387 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272623000388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000389 Transposase; Region: HTH_Tnp_1; pfam01527 272623000390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623000391 HTH-like domain; Region: HTH_21; pfam13276 272623000392 Integrase core domain; Region: rve; pfam00665 272623000393 Integrase core domain; Region: rve_3; pfam13683 272623000394 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000396 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623000397 putative transposase OrfB; Reviewed; Region: PHA02517 272623000398 HTH-like domain; Region: HTH_21; pfam13276 272623000399 Integrase core domain; Region: rve; pfam00665 272623000400 Integrase core domain; Region: rve_3; pfam13683 272623000401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623000402 HTH-like domain; Region: HTH_21; pfam13276 272623000403 Integrase core domain; Region: rve; pfam00665 272623000404 Integrase core domain; Region: rve_3; pfam13683 272623000405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000406 Transposase; Region: HTH_Tnp_1; pfam01527 272623000407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4472 272623000408 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272623000409 hypothetical protein; Provisional; Region: PRK13678 272623000410 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623000411 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272623000412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000413 NAD(P) binding site [chemical binding]; other site 272623000414 active site 272623000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 272623000416 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 272623000417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000418 NAD(P) binding site [chemical binding]; other site 272623000419 active site 272623000420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623000422 putative DNA binding site [nucleotide binding]; other site 272623000423 putative Zn2+ binding site [ion binding]; other site 272623000424 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272623000425 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000426 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000427 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000428 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000429 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000430 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000431 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000432 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000433 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000434 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000435 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000436 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000437 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000438 Cna protein B-type domain; Region: Cna_B; pfam05738 272623000439 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 272623000440 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272623000441 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272623000442 Predicted integral membrane protein [Function unknown]; Region: COG5523 272623000443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623000445 putative substrate translocation pore; other site 272623000446 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272623000447 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272623000448 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623000449 aminotransferase AlaT; Validated; Region: PRK09265 272623000450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000452 homodimer interface [polypeptide binding]; other site 272623000453 catalytic residue [active] 272623000454 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 272623000455 CodY GAF-like domain; Region: CodY; pfam06018 272623000456 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 272623000457 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272623000458 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272623000459 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 272623000460 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 272623000461 nudix motif; other site 272623000462 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272623000463 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272623000464 GatB domain; Region: GatB_Yqey; pfam02637 272623000465 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 272623000466 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 272623000467 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272623000468 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272623000469 DNA-binding site [nucleotide binding]; DNA binding site 272623000470 RNA-binding motif; other site 272623000471 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272623000472 Rhomboid family; Region: Rhomboid; pfam01694 272623000473 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 272623000474 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 272623000475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 272623000476 Sterol carrier protein domain; Region: SCP2_2; pfam13530 272623000477 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272623000478 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272623000479 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272623000480 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623000481 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623000482 trimer interface [polypeptide binding]; other site 272623000483 active site 272623000484 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272623000485 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272623000486 active site 272623000487 metal binding site [ion binding]; metal-binding site 272623000488 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272623000489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 272623000490 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272623000491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623000492 FeS/SAM binding site; other site 272623000493 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272623000494 dimer interface [polypeptide binding]; other site 272623000495 FMN binding site [chemical binding]; other site 272623000496 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623000497 substrate binding pocket [chemical binding]; other site 272623000498 chain length determination region; other site 272623000499 substrate-Mg2+ binding site; other site 272623000500 catalytic residues [active] 272623000501 aspartate-rich region 1; other site 272623000502 active site lid residues [active] 272623000503 aspartate-rich region 2; other site 272623000504 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 272623000505 putative active site [active] 272623000506 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272623000507 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272623000508 G1 box; other site 272623000509 GTP/Mg2+ binding site [chemical binding]; other site 272623000510 Switch I region; other site 272623000511 G2 box; other site 272623000512 G3 box; other site 272623000513 Switch II region; other site 272623000514 G4 box; other site 272623000515 G5 box; other site 272623000516 Nucleoside recognition; Region: Gate; pfam07670 272623000517 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272623000518 Nucleoside recognition; Region: Gate; pfam07670 272623000519 FeoA domain; Region: FeoA; pfam04023 272623000520 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272623000521 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272623000522 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272623000523 DAK2 domain; Region: Dak2; pfam02734 272623000524 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272623000525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272623000526 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272623000527 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 272623000528 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272623000529 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272623000530 substrate binding site; other site 272623000531 tetramer interface; other site 272623000532 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 272623000533 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272623000534 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272623000535 NAD binding site [chemical binding]; other site 272623000536 substrate binding site [chemical binding]; other site 272623000537 homodimer interface [polypeptide binding]; other site 272623000538 active site 272623000539 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272623000540 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272623000541 NADP binding site [chemical binding]; other site 272623000542 active site 272623000543 putative substrate binding site [chemical binding]; other site 272623000544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623000545 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 272623000546 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623000547 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 272623000548 Probable Catalytic site; other site 272623000549 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272623000550 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272623000551 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272623000552 Walker A/P-loop; other site 272623000553 ATP binding site [chemical binding]; other site 272623000554 Q-loop/lid; other site 272623000555 ABC transporter signature motif; other site 272623000556 Walker B; other site 272623000557 D-loop; other site 272623000558 H-loop/switch region; other site 272623000559 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272623000560 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272623000561 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000562 active site 272623000563 Domain of unknown function (DUF947); Region: DUF947; pfam06102 272623000564 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 272623000565 Predicted membrane protein [Function unknown]; Region: COG4713 272623000566 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623000567 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272623000568 Ligand binding site; other site 272623000569 Putative Catalytic site; other site 272623000570 DXD motif; other site 272623000571 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 272623000572 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272623000573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000574 NAD(P) binding site [chemical binding]; other site 272623000575 active site 272623000576 colanic acid exporter; Provisional; Region: PRK10459 272623000577 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272623000578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623000579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272623000580 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 272623000581 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623000582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000583 active site 272623000584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623000585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000586 active site 272623000587 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272623000588 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272623000589 active site 272623000590 catalytic site [active] 272623000591 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623000592 active site 272623000593 nucleotide binding site [chemical binding]; other site 272623000594 HIGH motif; other site 272623000595 KMSKS motif; other site 272623000596 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272623000597 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272623000598 active site 272623000599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272623000600 GTPase YqeH; Provisional; Region: PRK13796 272623000601 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272623000602 GTP/Mg2+ binding site [chemical binding]; other site 272623000603 G4 box; other site 272623000604 G5 box; other site 272623000605 G1 box; other site 272623000606 Switch I region; other site 272623000607 G2 box; other site 272623000608 G3 box; other site 272623000609 Switch II region; other site 272623000610 GTPases [General function prediction only]; Region: HflX; COG2262 272623000611 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272623000612 HflX GTPase family; Region: HflX; cd01878 272623000613 G1 box; other site 272623000614 GTP/Mg2+ binding site [chemical binding]; other site 272623000615 Switch I region; other site 272623000616 G2 box; other site 272623000617 G3 box; other site 272623000618 Switch II region; other site 272623000619 G4 box; other site 272623000620 G5 box; other site 272623000621 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 272623000622 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272623000623 active site 272623000624 (T/H)XGH motif; other site 272623000625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623000626 Zn2+ binding site [ion binding]; other site 272623000627 Mg2+ binding site [ion binding]; other site 272623000628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000629 Coenzyme A binding pocket [chemical binding]; other site 272623000630 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272623000631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623000632 S-adenosylmethionine binding site [chemical binding]; other site 272623000633 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 272623000634 hypothetical protein; Provisional; Region: PRK13670 272623000635 hypothetical protein; Provisional; Region: PRK12378 272623000636 Uncharacterized conserved protein [Function unknown]; Region: COG4832 272623000637 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272623000638 ligand binding site [chemical binding]; other site 272623000639 active site 272623000640 UGI interface [polypeptide binding]; other site 272623000641 catalytic site [active] 272623000642 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 272623000643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623000646 putative substrate translocation pore; other site 272623000647 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623000648 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623000649 DNA binding residues [nucleotide binding] 272623000650 putative dimer interface [polypeptide binding]; other site 272623000651 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272623000652 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623000653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623000654 active site 272623000655 motif I; other site 272623000656 motif II; other site 272623000657 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623000658 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 272623000659 substrate binding site [chemical binding]; other site 272623000660 hinge regions; other site 272623000661 ADP binding site [chemical binding]; other site 272623000662 catalytic site [active] 272623000663 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 272623000664 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272623000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623000666 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272623000667 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272623000668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 272623000669 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272623000670 amphipathic channel; other site 272623000671 Asn-Pro-Ala signature motifs; other site 272623000672 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 272623000673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623000675 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272623000676 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272623000677 Walker A/P-loop; other site 272623000678 ATP binding site [chemical binding]; other site 272623000679 Q-loop/lid; other site 272623000680 ABC transporter signature motif; other site 272623000681 Walker B; other site 272623000682 D-loop; other site 272623000683 H-loop/switch region; other site 272623000684 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272623000685 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272623000686 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272623000687 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272623000688 putative RNA binding site [nucleotide binding]; other site 272623000689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272623000690 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 272623000691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623000692 HI0933-like protein; Region: HI0933_like; pfam03486 272623000693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623000694 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272623000695 putative substrate binding site [chemical binding]; other site 272623000696 putative ATP binding site [chemical binding]; other site 272623000697 Phage envelope protein [General function prediction only]; Region: COG5562 272623000698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623000700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623000701 Walker A/P-loop; other site 272623000702 ATP binding site [chemical binding]; other site 272623000703 Q-loop/lid; other site 272623000704 ABC transporter signature motif; other site 272623000705 Walker B; other site 272623000706 D-loop; other site 272623000707 H-loop/switch region; other site 272623000708 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 272623000709 putative oxidoreductase; Provisional; Region: PRK10206 272623000710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272623000711 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272623000712 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272623000713 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 272623000714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623000715 active site 272623000716 catalytic tetrad [active] 272623000717 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623000718 catalytic triad [active] 272623000719 conserved cis-peptide bond; other site 272623000720 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272623000721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623000722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623000723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623000724 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272623000725 ATP cone domain; Region: ATP-cone; pfam03477 272623000726 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272623000727 effector binding site; other site 272623000728 active site 272623000729 Zn binding site [ion binding]; other site 272623000730 glycine loop; other site 272623000731 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 272623000732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623000733 FeS/SAM binding site; other site 272623000734 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 272623000735 enolase; Provisional; Region: eno; PRK00077 272623000736 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272623000737 dimer interface [polypeptide binding]; other site 272623000738 metal binding site [ion binding]; metal-binding site 272623000739 substrate binding pocket [chemical binding]; other site 272623000740 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 272623000741 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000742 Walker A/P-loop; other site 272623000743 ATP binding site [chemical binding]; other site 272623000744 Q-loop/lid; other site 272623000745 ABC transporter signature motif; other site 272623000746 Walker B; other site 272623000747 D-loop; other site 272623000748 H-loop/switch region; other site 272623000749 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 272623000750 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000751 Walker A/P-loop; other site 272623000752 ATP binding site [chemical binding]; other site 272623000753 Q-loop/lid; other site 272623000754 ABC transporter signature motif; other site 272623000755 Walker B; other site 272623000756 D-loop; other site 272623000757 H-loop/switch region; other site 272623000758 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272623000759 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 272623000760 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272623000761 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272623000762 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272623000763 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272623000764 trimer interface [polypeptide binding]; other site 272623000765 active site 272623000766 substrate binding site [chemical binding]; other site 272623000767 CoA binding site [chemical binding]; other site 272623000768 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272623000769 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272623000770 metal binding site [ion binding]; metal-binding site 272623000771 putative dimer interface [polypeptide binding]; other site 272623000772 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272623000773 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272623000774 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272623000775 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272623000776 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272623000777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623000778 RNA binding surface [nucleotide binding]; other site 272623000779 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272623000780 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272623000781 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272623000782 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272623000783 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272623000784 RNA binding site [nucleotide binding]; other site 272623000785 hypothetical protein; Provisional; Region: PRK04351 272623000786 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272623000787 active site 272623000788 purine riboside binding site [chemical binding]; other site 272623000789 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272623000790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272623000791 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272623000792 hypothetical protein; Provisional; Region: PRK13667 272623000793 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272623000794 Glycoprotease family; Region: Peptidase_M22; pfam00814 272623000795 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272623000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000797 Coenzyme A binding pocket [chemical binding]; other site 272623000798 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272623000799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000800 Coenzyme A binding pocket [chemical binding]; other site 272623000801 UGMP family protein; Validated; Region: PRK09604 272623000802 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272623000803 Uncharacterized protein conserved in Streptococci; Region: SP_1775_like; cl19119 272623000804 oligomer interface [polypeptide binding]; other site 272623000805 putative ligand binding site [chemical binding]; other site 272623000806 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272623000807 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272623000808 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272623000809 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272623000810 Walker A/P-loop; other site 272623000811 ATP binding site [chemical binding]; other site 272623000812 Q-loop/lid; other site 272623000813 ABC transporter signature motif; other site 272623000814 Walker B; other site 272623000815 D-loop; other site 272623000816 H-loop/switch region; other site 272623000817 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272623000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000819 dimer interface [polypeptide binding]; other site 272623000820 conserved gate region; other site 272623000821 putative PBP binding loops; other site 272623000822 ABC-ATPase subunit interface; other site 272623000823 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272623000824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000825 dimer interface [polypeptide binding]; other site 272623000826 conserved gate region; other site 272623000827 putative PBP binding loops; other site 272623000828 ABC-ATPase subunit interface; other site 272623000829 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272623000830 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272623000831 active site 272623000832 metal binding site [ion binding]; metal-binding site 272623000833 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272623000834 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272623000835 dimer interface [polypeptide binding]; other site 272623000836 catalytic triad [active] 272623000837 peroxidatic and resolving cysteines [active] 272623000838 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 272623000839 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 272623000840 Zn binding site [ion binding]; other site 272623000841 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 272623000842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623000844 putative substrate translocation pore; other site 272623000845 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623000846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623000847 putative DNA binding site [nucleotide binding]; other site 272623000848 putative Zn2+ binding site [ion binding]; other site 272623000849 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272623000850 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272623000851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623000853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623000854 Walker A/P-loop; other site 272623000855 ATP binding site [chemical binding]; other site 272623000856 Q-loop/lid; other site 272623000857 ABC transporter signature motif; other site 272623000858 Walker B; other site 272623000859 D-loop; other site 272623000860 H-loop/switch region; other site 272623000861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623000863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623000864 Walker A/P-loop; other site 272623000865 ATP binding site [chemical binding]; other site 272623000866 Q-loop/lid; other site 272623000867 ABC transporter signature motif; other site 272623000868 Walker B; other site 272623000869 D-loop; other site 272623000870 H-loop/switch region; other site 272623000871 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272623000872 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272623000873 hinge; other site 272623000874 active site 272623000875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 272623000876 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 272623000877 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272623000878 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272623000879 putative deacylase active site [active] 272623000880 Predicted membrane protein [Function unknown]; Region: COG3859 272623000881 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272623000882 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272623000883 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272623000884 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272623000885 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272623000886 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272623000887 Walker A/P-loop; other site 272623000888 ATP binding site [chemical binding]; other site 272623000889 Q-loop/lid; other site 272623000890 ABC transporter signature motif; other site 272623000891 Walker B; other site 272623000892 D-loop; other site 272623000893 H-loop/switch region; other site 272623000894 NIL domain; Region: NIL; pfam09383 272623000895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000896 dimer interface [polypeptide binding]; other site 272623000897 conserved gate region; other site 272623000898 putative PBP binding loops; other site 272623000899 ABC-ATPase subunit interface; other site 272623000900 hypothetical protein; Provisional; Region: PRK13661 272623000901 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272623000902 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000903 Walker A/P-loop; other site 272623000904 ATP binding site [chemical binding]; other site 272623000905 Q-loop/lid; other site 272623000906 ABC transporter signature motif; other site 272623000907 Walker B; other site 272623000908 D-loop; other site 272623000909 H-loop/switch region; other site 272623000910 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 272623000911 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000912 Walker A/P-loop; other site 272623000913 ATP binding site [chemical binding]; other site 272623000914 Q-loop/lid; other site 272623000915 ABC transporter signature motif; other site 272623000916 Walker B; other site 272623000917 D-loop; other site 272623000918 H-loop/switch region; other site 272623000919 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272623000920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623000921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000922 non-specific DNA binding site [nucleotide binding]; other site 272623000923 salt bridge; other site 272623000924 sequence-specific DNA binding site [nucleotide binding]; other site 272623000925 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623000926 ABC-ATPase subunit interface; other site 272623000927 dimer interface [polypeptide binding]; other site 272623000928 putative PBP binding regions; other site 272623000929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623000930 ABC-ATPase subunit interface; other site 272623000931 dimer interface [polypeptide binding]; other site 272623000932 putative PBP binding regions; other site 272623000933 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272623000934 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272623000935 putative ligand binding residues [chemical binding]; other site 272623000936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623000937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623000938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272623000939 dimerization interface [polypeptide binding]; other site 272623000940 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272623000941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000942 putative substrate translocation pore; other site 272623000943 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623000944 active site 272623000945 catalytic tetrad [active] 272623000946 Predicted transcriptional regulators [Transcription]; Region: COG1733 272623000947 dimerization interface [polypeptide binding]; other site 272623000948 putative Zn2+ binding site [ion binding]; other site 272623000949 putative DNA binding site [nucleotide binding]; other site 272623000950 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272623000951 putative metal binding site [ion binding]; other site 272623000952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623000953 catalytic core [active] 272623000954 peroxiredoxin; Region: AhpC; TIGR03137 272623000955 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272623000956 dimer interface [polypeptide binding]; other site 272623000957 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272623000958 catalytic triad [active] 272623000959 peroxidatic and resolving cysteines [active] 272623000960 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 272623000961 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 272623000962 catalytic residue [active] 272623000963 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 272623000964 catalytic residues [active] 272623000965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623000966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623000967 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272623000968 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272623000969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272623000970 recombination protein RecR; Reviewed; Region: recR; PRK00076 272623000971 RecR protein; Region: RecR; pfam02132 272623000972 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272623000973 putative active site [active] 272623000974 putative metal-binding site [ion binding]; other site 272623000975 tetramer interface [polypeptide binding]; other site 272623000976 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272623000977 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272623000978 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272623000979 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272623000980 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623000981 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623000982 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623000983 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623000984 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623000985 peptide binding site [polypeptide binding]; other site 272623000986 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623000987 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623000988 peptide binding site [polypeptide binding]; other site 272623000989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272623000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000991 dimer interface [polypeptide binding]; other site 272623000992 conserved gate region; other site 272623000993 putative PBP binding loops; other site 272623000994 ABC-ATPase subunit interface; other site 272623000995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272623000996 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272623000997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000998 dimer interface [polypeptide binding]; other site 272623000999 conserved gate region; other site 272623001000 putative PBP binding loops; other site 272623001001 ABC-ATPase subunit interface; other site 272623001002 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272623001003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272623001004 Walker A/P-loop; other site 272623001005 ATP binding site [chemical binding]; other site 272623001006 Q-loop/lid; other site 272623001007 ABC transporter signature motif; other site 272623001008 Walker B; other site 272623001009 D-loop; other site 272623001010 H-loop/switch region; other site 272623001011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272623001012 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272623001013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272623001014 Walker A/P-loop; other site 272623001015 ATP binding site [chemical binding]; other site 272623001016 Q-loop/lid; other site 272623001017 ABC transporter signature motif; other site 272623001018 Walker B; other site 272623001019 D-loop; other site 272623001020 H-loop/switch region; other site 272623001021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272623001022 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272623001023 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272623001024 G1 box; other site 272623001025 putative GEF interaction site [polypeptide binding]; other site 272623001026 GTP/Mg2+ binding site [chemical binding]; other site 272623001027 Switch I region; other site 272623001028 G2 box; other site 272623001029 G3 box; other site 272623001030 Switch II region; other site 272623001031 G4 box; other site 272623001032 G5 box; other site 272623001033 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272623001034 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272623001035 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272623001036 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272623001037 ATP binding site [chemical binding]; other site 272623001038 Mg++ binding site [ion binding]; other site 272623001039 motif III; other site 272623001040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001041 nucleotide binding region [chemical binding]; other site 272623001042 ATP-binding site [chemical binding]; other site 272623001043 GTPase Era; Reviewed; Region: era; PRK00089 272623001044 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272623001045 G1 box; other site 272623001046 GTP/Mg2+ binding site [chemical binding]; other site 272623001047 Switch I region; other site 272623001048 G2 box; other site 272623001049 Switch II region; other site 272623001050 G3 box; other site 272623001051 G4 box; other site 272623001052 G5 box; other site 272623001053 KH domain; Region: KH_2; pfam07650 272623001054 asparagine synthetase B; Provisional; Region: asnB; PRK09431 272623001055 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272623001056 dimer interface [polypeptide binding]; other site 272623001057 active site 272623001058 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272623001059 Ligand Binding Site [chemical binding]; other site 272623001060 Molecular Tunnel; other site 272623001061 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272623001062 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272623001063 DNA binding site [nucleotide binding] 272623001064 catalytic residue [active] 272623001065 H2TH interface [polypeptide binding]; other site 272623001066 putative catalytic residues [active] 272623001067 turnover-facilitating residue; other site 272623001068 intercalation triad [nucleotide binding]; other site 272623001069 8OG recognition residue [nucleotide binding]; other site 272623001070 putative reading head residues; other site 272623001071 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272623001072 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272623001073 recombinase A; Provisional; Region: recA; PRK09354 272623001074 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272623001075 hexamer interface [polypeptide binding]; other site 272623001076 Walker A motif; other site 272623001077 ATP binding site [chemical binding]; other site 272623001078 Walker B motif; other site 272623001079 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623001080 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623001081 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 272623001082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 272623001083 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272623001084 putative active site [active] 272623001085 putative metal binding residues [ion binding]; other site 272623001086 signature motif; other site 272623001087 putative triphosphate binding site [ion binding]; other site 272623001088 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 272623001089 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623001090 synthetase active site [active] 272623001091 NTP binding site [chemical binding]; other site 272623001092 metal binding site [ion binding]; metal-binding site 272623001093 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 272623001094 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272623001095 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272623001096 active site 272623001097 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272623001098 active site 272623001099 lysine transporter; Provisional; Region: PRK10836 272623001100 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272623001101 Predicted flavoprotein [General function prediction only]; Region: COG0431 272623001102 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272623001103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001104 Transposase; Region: HTH_Tnp_1; pfam01527 272623001105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623001106 HTH-like domain; Region: HTH_21; pfam13276 272623001107 Integrase core domain; Region: rve; pfam00665 272623001108 Integrase core domain; Region: rve_3; pfam13683 272623001109 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623001110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001111 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623001112 putative transposase OrfB; Reviewed; Region: PHA02517 272623001113 HTH-like domain; Region: HTH_21; pfam13276 272623001114 Integrase core domain; Region: rve; pfam00665 272623001115 Integrase core domain; Region: rve_2; pfam13333 272623001116 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272623001117 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272623001118 dimer interface [polypeptide binding]; other site 272623001119 putative anticodon binding site; other site 272623001120 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272623001121 motif 1; other site 272623001122 active site 272623001123 motif 2; other site 272623001124 motif 3; other site 272623001125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623001126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623001127 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272623001128 dimerization interface [polypeptide binding]; other site 272623001129 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 272623001130 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623001131 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623001132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623001133 NAD binding site [chemical binding]; other site 272623001134 dimer interface [polypeptide binding]; other site 272623001135 substrate binding site [chemical binding]; other site 272623001136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623001137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623001138 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272623001139 dimerization interface [polypeptide binding]; other site 272623001140 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 272623001141 gating phenylalanine in ion channel; other site 272623001142 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272623001143 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272623001144 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272623001145 Ligand Binding Site [chemical binding]; other site 272623001146 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623001147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001148 putative substrate translocation pore; other site 272623001149 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272623001150 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 272623001151 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272623001152 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272623001153 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272623001154 active site 272623001155 HIGH motif; other site 272623001156 dimer interface [polypeptide binding]; other site 272623001157 KMSKS motif; other site 272623001158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623001159 RNA binding surface [nucleotide binding]; other site 272623001160 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272623001161 Transglycosylase; Region: Transgly; pfam00912 272623001162 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272623001163 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272623001164 oligomer interface [polypeptide binding]; other site 272623001165 active site 272623001166 metal binding site [ion binding]; metal-binding site 272623001167 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272623001168 catalytic residues [active] 272623001169 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 272623001170 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272623001171 putative tRNA-binding site [nucleotide binding]; other site 272623001172 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272623001173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623001174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623001175 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623001176 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272623001177 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623001178 dimer interface [polypeptide binding]; other site 272623001179 ssDNA binding site [nucleotide binding]; other site 272623001180 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623001181 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272623001182 oligomerisation interface [polypeptide binding]; other site 272623001183 mobile loop; other site 272623001184 roof hairpin; other site 272623001185 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272623001186 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272623001187 ring oligomerisation interface [polypeptide binding]; other site 272623001188 ATP/Mg binding site [chemical binding]; other site 272623001189 stacking interactions; other site 272623001190 hinge regions; other site 272623001191 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272623001192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272623001193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272623001194 putative active site [active] 272623001195 heme pocket [chemical binding]; other site 272623001196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623001197 dimer interface [polypeptide binding]; other site 272623001198 phosphorylation site [posttranslational modification] 272623001199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623001200 ATP binding site [chemical binding]; other site 272623001201 Mg2+ binding site [ion binding]; other site 272623001202 G-X-G motif; other site 272623001203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623001205 active site 272623001206 phosphorylation site [posttranslational modification] 272623001207 intermolecular recognition site; other site 272623001208 dimerization interface [polypeptide binding]; other site 272623001209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623001210 DNA binding site [nucleotide binding] 272623001211 thymidylate kinase; Validated; Region: tmk; PRK00698 272623001212 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272623001213 TMP-binding site; other site 272623001214 ATP-binding site [chemical binding]; other site 272623001215 DNA polymerase III subunit delta'; Validated; Region: PRK07276 272623001216 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272623001217 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 272623001218 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 272623001219 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272623001220 putative SAM binding site [chemical binding]; other site 272623001221 putative homodimer interface [polypeptide binding]; other site 272623001222 mevalonate kinase; Region: mevalon_kin; TIGR00549 272623001223 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272623001224 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623001225 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272623001226 diphosphomevalonate decarboxylase; Region: PLN02407 272623001227 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 272623001228 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272623001229 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623001230 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272623001231 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272623001232 homotetramer interface [polypeptide binding]; other site 272623001233 FMN binding site [chemical binding]; other site 272623001234 homodimer contacts [polypeptide binding]; other site 272623001235 putative active site [active] 272623001236 putative substrate binding site [chemical binding]; other site 272623001237 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272623001238 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272623001239 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272623001240 carbon starvation protein A; Provisional; Region: PRK15015 272623001241 Carbon starvation protein CstA; Region: CstA; pfam02554 272623001242 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272623001243 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272623001244 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272623001245 ATP binding site [chemical binding]; other site 272623001246 Mg++ binding site [ion binding]; other site 272623001247 motif III; other site 272623001248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001249 nucleotide binding region [chemical binding]; other site 272623001250 ATP-binding site [chemical binding]; other site 272623001251 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623001252 putative active site [active] 272623001253 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623001254 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623001255 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001256 putative active site [active] 272623001257 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272623001258 active site 272623001259 P-loop; other site 272623001260 phosphorylation site [posttranslational modification] 272623001261 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272623001262 methionine cluster; other site 272623001263 active site 272623001264 phosphorylation site [posttranslational modification] 272623001265 metal binding site [ion binding]; metal-binding site 272623001266 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623001267 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623001268 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001269 putative active site [active] 272623001270 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 272623001271 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272623001272 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 272623001273 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623001274 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272623001275 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272623001276 nucleotide binding pocket [chemical binding]; other site 272623001277 K-X-D-G motif; other site 272623001278 catalytic site [active] 272623001279 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272623001280 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272623001281 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272623001282 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272623001283 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272623001284 Dimer interface [polypeptide binding]; other site 272623001285 BRCT sequence motif; other site 272623001286 putative lipid kinase; Reviewed; Region: PRK13055 272623001287 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272623001288 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272623001289 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272623001290 Walker A/P-loop; other site 272623001291 ATP binding site [chemical binding]; other site 272623001292 Q-loop/lid; other site 272623001293 ABC transporter signature motif; other site 272623001294 Walker B; other site 272623001295 D-loop; other site 272623001296 H-loop/switch region; other site 272623001297 TOBE domain; Region: TOBE_2; pfam08402 272623001298 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272623001299 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272623001300 dimer interface [polypeptide binding]; other site 272623001301 PYR/PP interface [polypeptide binding]; other site 272623001302 TPP binding site [chemical binding]; other site 272623001303 substrate binding site [chemical binding]; other site 272623001304 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272623001305 Domain of unknown function; Region: EKR; smart00890 272623001306 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272623001307 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272623001308 TPP-binding site [chemical binding]; other site 272623001309 dimer interface [polypeptide binding]; other site 272623001310 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272623001311 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272623001312 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272623001313 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272623001314 active site 272623001315 substrate binding site [chemical binding]; other site 272623001316 metal binding site [ion binding]; metal-binding site 272623001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623001318 DNA-binding site [nucleotide binding]; DNA binding site 272623001319 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272623001320 UTRA domain; Region: UTRA; pfam07702 272623001321 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272623001322 HPr interaction site; other site 272623001323 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623001324 active site 272623001325 phosphorylation site [posttranslational modification] 272623001326 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272623001327 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623001328 active site turn [active] 272623001329 phosphorylation site [posttranslational modification] 272623001330 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272623001331 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272623001332 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272623001333 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272623001334 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272623001335 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272623001336 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623001337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001338 motif II; other site 272623001339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623001340 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272623001341 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272623001342 nucleophilic elbow; other site 272623001343 catalytic triad; other site 272623001344 LIN37; Region: LIN37; pfam15306 272623001345 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272623001346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272623001347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001348 Coenzyme A binding pocket [chemical binding]; other site 272623001349 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272623001350 Bacteriophage bIL309 272623001351 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 272623001352 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272623001353 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623001354 Int/Topo IB signature motif; other site 272623001355 Short C-terminal domain; Region: SHOCT; pfam09851 272623001356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623001357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001358 non-specific DNA binding site [nucleotide binding]; other site 272623001359 salt bridge; other site 272623001360 sequence-specific DNA binding site [nucleotide binding]; other site 272623001361 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272623001362 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272623001363 Catalytic site [active] 272623001364 putative transcription regulator; Region: PHA00212 272623001365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001366 non-specific DNA binding site [nucleotide binding]; other site 272623001367 salt bridge; other site 272623001368 sequence-specific DNA binding site [nucleotide binding]; other site 272623001369 Prophage antirepressor [Transcription]; Region: COG3617 272623001370 BRO family, N-terminal domain; Region: Bro-N; smart01040 272623001371 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 272623001372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 272623001373 Lactococcus bacteriophage putative transcription regulator; Region: Phage_Treg; pfam04761 272623001374 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 272623001375 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 272623001376 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 272623001377 Putative replisome organizer protein C-terminus; Region: Rep_Org_C; pfam06926 272623001378 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272623001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001380 Walker A motif; other site 272623001381 ATP binding site [chemical binding]; other site 272623001382 Walker B motif; other site 272623001383 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 272623001384 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623001385 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272623001386 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623001387 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623001388 trimer interface [polypeptide binding]; other site 272623001389 active site 272623001390 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623001391 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623001392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001393 non-specific DNA binding site [nucleotide binding]; other site 272623001394 salt bridge; other site 272623001395 sequence-specific DNA binding site [nucleotide binding]; other site 272623001396 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623001397 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623001398 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272623001399 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 272623001400 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623001401 Phage Terminase; Region: Terminase_1; cl19862 272623001402 Phage-related protein [Function unknown]; Region: COG4695 272623001403 Phage head maturation protease [General function prediction only]; Region: COG3740 272623001404 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272623001405 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 272623001406 Phage capsid family; Region: Phage_capsid; pfam05065 272623001407 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 272623001408 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272623001409 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 272623001410 Protein of unknown function (DUF806); Region: DUF806; pfam05657 272623001411 Phage major tail protein; Region: Phage_tail; pfam04630 272623001412 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 272623001413 Phage-related tail protein [Function unknown]; Region: COG5283 272623001414 tape measure domain; Region: tape_meas_nterm; TIGR02675 272623001415 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272623001416 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272623001417 catalytic residue [active] 272623001418 Phage tail protein; Region: Sipho_tail; pfam05709 272623001419 Phage tail protein; Region: Sipho_tail; cl17486 272623001420 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272623001421 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506 272623001422 Phage lysis protein, holin; Region: Phage_holin; cl04675 272623001423 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 272623001424 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623001425 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272623001426 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272623001427 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272623001428 dimerization interface 3.5A [polypeptide binding]; other site 272623001429 active site 272623001430 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272623001431 dimer interface [polypeptide binding]; other site 272623001432 substrate binding site [chemical binding]; other site 272623001433 ATP binding site [chemical binding]; other site 272623001434 Predicted membrane protein [Function unknown]; Region: COG4720 272623001435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4475 272623001436 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272623001437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001438 catalytic residue [active] 272623001439 CTP synthetase; Validated; Region: pyrG; PRK05380 272623001440 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272623001441 Catalytic site [active] 272623001442 active site 272623001443 UTP binding site [chemical binding]; other site 272623001444 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272623001445 active site 272623001446 putative oxyanion hole; other site 272623001447 catalytic triad [active] 272623001448 Predicted membrane protein [Function unknown]; Region: COG4420 272623001449 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 272623001450 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272623001451 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272623001452 Substrate-binding site [chemical binding]; other site 272623001453 Substrate specificity [chemical binding]; other site 272623001454 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 272623001455 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272623001456 active site 272623001457 PHP Thumb interface [polypeptide binding]; other site 272623001458 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272623001459 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272623001460 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272623001461 generic binding surface II; other site 272623001462 generic binding surface I; other site 272623001463 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272623001464 EDD domain protein, DegV family; Region: DegV; TIGR00762 272623001465 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272623001466 active site 272623001467 catalytic triad [active] 272623001468 oxyanion hole [active] 272623001469 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272623001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 272623001471 histone-like DNA-binding protein HU; Region: HU; cd13831 272623001472 dimer interface [polypeptide binding]; other site 272623001473 DNA binding site [nucleotide binding] 272623001474 Bacteriophage bIL312 272623001475 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272623001476 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272623001477 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 272623001478 Int/Topo IB signature motif; other site 272623001479 Peptidase family M48; Region: Peptidase_M48; cl12018 272623001480 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623001481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001482 non-specific DNA binding site [nucleotide binding]; other site 272623001483 salt bridge; other site 272623001484 sequence-specific DNA binding site [nucleotide binding]; other site 272623001485 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272623001486 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623001487 HTH domain; Region: HTH_11; cl17392 272623001488 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 272623001489 Virulence-associated protein E; Region: VirE; pfam05272 272623001490 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272623001491 Phage head maturation protease [General function prediction only]; Region: COG3740 272623001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 272623001493 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272623001494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272623001495 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 272623001496 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272623001497 DNA-binding site [nucleotide binding]; DNA binding site 272623001498 RNA-binding motif; other site 272623001499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272623001500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001501 Coenzyme A binding pocket [chemical binding]; other site 272623001502 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272623001503 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272623001504 DNA binding site [nucleotide binding] 272623001505 active site 272623001506 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272623001507 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272623001508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623001509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623001510 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272623001511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272623001512 Walker A/P-loop; other site 272623001513 ATP binding site [chemical binding]; other site 272623001514 Q-loop/lid; other site 272623001515 ABC transporter signature motif; other site 272623001516 Walker B; other site 272623001517 D-loop; other site 272623001518 H-loop/switch region; other site 272623001519 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272623001520 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272623001521 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272623001522 LytTr DNA-binding domain; Region: LytTR; pfam04397 272623001523 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272623001524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001525 catalytic residue [active] 272623001526 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623001527 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623001528 NlpC/P60 family; Region: NLPC_P60; cl17555 272623001529 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623001530 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623001531 peptide binding site [polypeptide binding]; other site 272623001532 cysteine synthase; Region: PLN02565 272623001533 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272623001534 dimer interface [polypeptide binding]; other site 272623001535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623001536 catalytic residue [active] 272623001537 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272623001538 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623001539 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623001540 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623001541 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272623001542 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272623001543 Transglycosylase; Region: Transgly; pfam00912 272623001544 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272623001545 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 272623001546 hypothetical protein; Provisional; Region: PRK13660 272623001547 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623001548 putative catalytic residues [active] 272623001549 thiol/disulfide switch; other site 272623001550 hypothetical protein; Provisional; Region: PRK04387 272623001551 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272623001552 active site 272623001553 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272623001554 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272623001555 hinge; other site 272623001556 active site 272623001557 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 272623001558 trigger factor; Provisional; Region: tig; PRK01490 272623001559 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272623001560 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272623001561 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272623001562 DNA primase; Validated; Region: dnaG; PRK05667 272623001563 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272623001564 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272623001565 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272623001566 active site 272623001567 metal binding site [ion binding]; metal-binding site 272623001568 interdomain interaction site; other site 272623001569 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272623001570 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623001571 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272623001572 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272623001573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272623001574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272623001575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272623001576 DNA binding residues [nucleotide binding] 272623001577 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623001578 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623001579 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001580 putative active site [active] 272623001581 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272623001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001583 putative substrate translocation pore; other site 272623001584 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272623001585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001586 Walker A motif; other site 272623001587 ATP binding site [chemical binding]; other site 272623001588 Walker B motif; other site 272623001589 arginine finger; other site 272623001590 UvrB/uvrC motif; Region: UVR; pfam02151 272623001591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001592 Walker A motif; other site 272623001593 ATP binding site [chemical binding]; other site 272623001594 Walker B motif; other site 272623001595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272623001596 Predicted transcriptional regulator [Transcription]; Region: COG1959 272623001597 Rrf2 family protein; Region: rrf2_super; TIGR00738 272623001598 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272623001599 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272623001600 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272623001601 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272623001602 active site 272623001603 catalytic residues [active] 272623001604 metal binding site [ion binding]; metal-binding site 272623001605 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272623001606 putative active site [active] 272623001607 Ap4A binding site [chemical binding]; other site 272623001608 nudix motif; other site 272623001609 putative metal binding site [ion binding]; other site 272623001610 excinuclease ABC subunit B; Provisional; Region: PRK05298 272623001611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623001612 ATP binding site [chemical binding]; other site 272623001613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001614 nucleotide binding region [chemical binding]; other site 272623001615 ATP-binding site [chemical binding]; other site 272623001616 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272623001617 UvrB/uvrC motif; Region: UVR; pfam02151 272623001618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623001619 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623001620 substrate binding pocket [chemical binding]; other site 272623001621 membrane-bound complex binding site; other site 272623001622 hinge residues; other site 272623001623 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 272623001624 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 272623001625 metal binding site [ion binding]; metal-binding site 272623001626 dimer interface [polypeptide binding]; other site 272623001627 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272623001628 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272623001629 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272623001630 NAD binding site [chemical binding]; other site 272623001631 homotetramer interface [polypeptide binding]; other site 272623001632 homodimer interface [polypeptide binding]; other site 272623001633 substrate binding site [chemical binding]; other site 272623001634 active site 272623001635 retinal-specific rim ABC transporter; Region: rim_protein; TIGR01257 272623001636 OxaA-like protein precursor; Provisional; Region: PRK02463 272623001637 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272623001638 Eukaryotic phosphomannomutase; Region: PMM; cl17107 272623001639 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272623001640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001641 active site 272623001642 motif I; other site 272623001643 motif II; other site 272623001644 Predicted membrane protein [Function unknown]; Region: COG4684 272623001645 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 272623001646 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 272623001647 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272623001648 active site 1 [active] 272623001649 dimer interface [polypeptide binding]; other site 272623001650 hexamer interface [polypeptide binding]; other site 272623001651 active site 2 [active] 272623001652 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272623001653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623001654 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 272623001655 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272623001656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272623001657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001658 Coenzyme A binding pocket [chemical binding]; other site 272623001659 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623001660 putative active site [active] 272623001661 hypothetical protein; Provisional; Region: PRK12473; cl11698 272623001662 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 272623001663 Predicted membrane protein [Function unknown]; Region: COG4852 272623001664 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272623001665 DAK2 domain; Region: Dak2; pfam02734 272623001666 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272623001667 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 272623001668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 272623001669 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272623001670 active site 272623001671 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272623001672 Uncharacterized conserved protein [Function unknown]; Region: COG2013 272623001673 DNA polymerase IV; Reviewed; Region: PRK03103 272623001674 Y-family of DNA polymerases; Region: PolY; cl12025 272623001675 active site 272623001676 DNA binding site [nucleotide binding] 272623001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001678 Coenzyme A binding pocket [chemical binding]; other site 272623001679 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272623001680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623001681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623001682 putative DNA binding site [nucleotide binding]; other site 272623001683 putative Zn2+ binding site [ion binding]; other site 272623001684 OsmC-like protein; Region: OsmC; cl00767 272623001685 thymidine kinase; Provisional; Region: PRK04296 272623001686 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272623001687 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272623001688 RF-1 domain; Region: RF-1; pfam00472 272623001689 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272623001690 dimer interface [polypeptide binding]; other site 272623001691 NADPH bind site [chemical binding]; other site 272623001692 FMN binding site [chemical binding]; other site 272623001693 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272623001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623001695 S-adenosylmethionine binding site [chemical binding]; other site 272623001696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001697 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272623001698 Coenzyme A binding pocket [chemical binding]; other site 272623001699 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272623001700 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272623001701 dimer interface [polypeptide binding]; other site 272623001702 active site 272623001703 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272623001704 folate binding site [chemical binding]; other site 272623001705 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272623001706 Lysozyme-like; Region: Lysozyme_like; pfam13702 272623001707 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 272623001708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001709 catalytic residue [active] 272623001710 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 272623001711 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272623001712 putative ligand binding site [chemical binding]; other site 272623001713 putative NAD binding site [chemical binding]; other site 272623001714 putative catalytic site [active] 272623001715 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272623001716 L-serine binding site [chemical binding]; other site 272623001717 ACT domain interface; other site 272623001718 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272623001719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001720 motif II; other site 272623001721 acylphosphatase; Provisional; Region: PRK14434 272623001722 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272623001723 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272623001724 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272623001725 flavodoxin; Validated; Region: PRK07308 272623001726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001727 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623001728 putative substrate translocation pore; other site 272623001729 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272623001730 active site 272623001731 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272623001732 Predicted membrane protein [Function unknown]; Region: COG2246 272623001733 Tim44-like domain; Region: Tim44; cl09208 272623001734 Predicted membrane protein [Function unknown]; Region: COG3326 272623001735 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 272623001736 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272623001737 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272623001738 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272623001739 Hpr binding site; other site 272623001740 active site 272623001741 homohexamer subunit interaction site [polypeptide binding]; other site 272623001742 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 272623001743 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 272623001744 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623001745 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272623001746 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272623001747 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272623001748 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272623001749 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623001750 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272623001751 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623001752 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272623001753 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 272623001754 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272623001755 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u4; cd03407 272623001756 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 272623001757 ribonuclease Z; Region: RNase_Z; TIGR02651 272623001758 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272623001759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001760 NAD(P) binding site [chemical binding]; other site 272623001761 active site 272623001762 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272623001763 DHH family; Region: DHH; pfam01368 272623001764 DHHA1 domain; Region: DHHA1; pfam02272 272623001765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 272623001766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623001767 active site 272623001768 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 272623001769 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272623001770 dimerization interface [polypeptide binding]; other site 272623001771 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272623001772 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272623001773 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272623001774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623001775 HTH-like domain; Region: HTH_21; pfam13276 272623001776 Integrase core domain; Region: rve; pfam00665 272623001777 Integrase core domain; Region: rve_3; pfam13683 272623001778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001779 Transposase; Region: HTH_Tnp_1; pfam01527 272623001780 HTH-like domain; Region: HTH_21; pfam13276 272623001781 Integrase core domain; Region: rve; pfam00665 272623001782 Integrase core domain; Region: rve_2; pfam13333 272623001783 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623001784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001785 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623001786 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 272623001787 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272623001788 Clp amino terminal domain; Region: Clp_N; pfam02861 272623001789 Clp amino terminal domain; Region: Clp_N; pfam02861 272623001790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001791 Walker A motif; other site 272623001792 ATP binding site [chemical binding]; other site 272623001793 Walker B motif; other site 272623001794 arginine finger; other site 272623001795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001796 Walker A motif; other site 272623001797 ATP binding site [chemical binding]; other site 272623001798 Walker B motif; other site 272623001799 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272623001800 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272623001801 30S subunit binding site; other site 272623001802 enolase; Provisional; Region: eno; PRK00077 272623001803 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272623001804 dimer interface [polypeptide binding]; other site 272623001805 metal binding site [ion binding]; metal-binding site 272623001806 substrate binding pocket [chemical binding]; other site 272623001807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623001808 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272623001809 active site 272623001810 DNA binding site [nucleotide binding] 272623001811 Int/Topo IB signature motif; other site 272623001812 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272623001813 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272623001814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623001815 ATP binding site [chemical binding]; other site 272623001816 putative Mg++ binding site [ion binding]; other site 272623001817 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 272623001818 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272623001819 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272623001820 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272623001821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272623001822 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272623001823 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272623001824 Peptidase family M50; Region: Peptidase_M50; pfam02163 272623001825 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272623001826 putative transposase OrfB; Reviewed; Region: PHA02517 272623001827 HTH-like domain; Region: HTH_21; pfam13276 272623001828 Integrase core domain; Region: rve; pfam00665 272623001829 Integrase core domain; Region: rve_3; pfam13683 272623001830 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 272623001831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623001832 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272623001833 Walker A/P-loop; other site 272623001834 ATP binding site [chemical binding]; other site 272623001835 Q-loop/lid; other site 272623001836 ABC transporter signature motif; other site 272623001837 Walker B; other site 272623001838 D-loop; other site 272623001839 H-loop/switch region; other site 272623001840 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623001841 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272623001842 FtsX-like permease family; Region: FtsX; pfam02687 272623001843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623001844 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272623001845 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272623001846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272623001847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272623001848 acyl-activating enzyme (AAE) consensus motif; other site 272623001849 acyl-activating enzyme (AAE) consensus motif; other site 272623001850 AMP binding site [chemical binding]; other site 272623001851 active site 272623001852 CoA binding site [chemical binding]; other site 272623001853 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272623001854 Cl binding site [ion binding]; other site 272623001855 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272623001856 oligomer interface [polypeptide binding]; other site 272623001857 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272623001858 Pyruvate formate lyase 1; Region: PFL1; cd01678 272623001859 coenzyme A binding site [chemical binding]; other site 272623001860 active site 272623001861 catalytic residues [active] 272623001862 glycine loop; other site 272623001863 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272623001864 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272623001865 CoA-binding site [chemical binding]; other site 272623001866 ATP-binding [chemical binding]; other site 272623001867 drug efflux system protein MdtG; Provisional; Region: PRK09874 272623001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001869 putative substrate translocation pore; other site 272623001870 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272623001871 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272623001872 Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038 272623001873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623001874 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272623001875 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272623001876 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272623001877 active site 272623001878 catalytic residues [active] 272623001879 metal binding site [ion binding]; metal-binding site 272623001880 homodimer binding site [polypeptide binding]; other site 272623001881 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 272623001882 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272623001883 carboxyltransferase (CT) interaction site; other site 272623001884 biotinylation site [posttranslational modification]; other site 272623001885 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272623001886 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 272623001887 dimer interface [polypeptide binding]; other site 272623001888 active site 272623001889 citrylCoA binding site [chemical binding]; other site 272623001890 oxalacetate/citrate binding site [chemical binding]; other site 272623001891 coenzyme A binding site [chemical binding]; other site 272623001892 catalytic triad [active] 272623001893 aconitate hydratase; Validated; Region: PRK09277 272623001894 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272623001895 substrate binding site [chemical binding]; other site 272623001896 ligand binding site [chemical binding]; other site 272623001897 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272623001898 substrate binding site [chemical binding]; other site 272623001899 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 272623001900 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272623001901 oligomer interface [polypeptide binding]; other site 272623001902 active site residues [active] 272623001903 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623001904 putative catalytic residues [active] 272623001905 thiol/disulfide switch; other site 272623001906 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623001907 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272623001908 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623001909 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623001910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001911 motif II; other site 272623001912 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623001913 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 272623001914 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272623001915 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272623001916 DXD motif; other site 272623001917 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623001918 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623001919 Integrase core domain; Region: rve; pfam00665 272623001920 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 272623001921 putative active site [active] 272623001922 putative metal binding site [ion binding]; other site 272623001923 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272623001924 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272623001925 Collagen binding domain; Region: Collagen_bind; pfam05737 272623001926 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272623001927 domain interaction interfaces [polypeptide binding]; other site 272623001928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001929 Coenzyme A binding pocket [chemical binding]; other site 272623001930 Uncharacterized conserved protein [Function unknown]; Region: COG3592 272623001931 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272623001932 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272623001933 active site 272623001934 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272623001935 AAA domain; Region: AAA_17; cl19128 272623001936 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272623001937 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272623001938 putative active site [active] 272623001939 putative metal binding site [ion binding]; other site 272623001940 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272623001941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623001942 S-adenosylmethionine binding site [chemical binding]; other site 272623001943 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272623001944 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272623001945 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272623001946 active site 272623001947 elongation factor P; Validated; Region: PRK00529 272623001948 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272623001949 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272623001950 RNA binding site [nucleotide binding]; other site 272623001951 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272623001952 RNA binding site [nucleotide binding]; other site 272623001953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272623001954 putative RNA binding site [nucleotide binding]; other site 272623001955 Transcription termination factor [Transcription]; Region: NusB; COG0781 272623001956 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272623001957 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272623001958 ligand binding site; other site 272623001959 oligomer interface; other site 272623001960 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272623001961 dimer interface [polypeptide binding]; other site 272623001962 N-terminal domain interface [polypeptide binding]; other site 272623001963 sulfate 1 binding site; other site 272623001964 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 272623001965 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272623001966 ligand binding site; other site 272623001967 oligomer interface; other site 272623001968 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272623001969 dimer interface [polypeptide binding]; other site 272623001970 N-terminal domain interface [polypeptide binding]; other site 272623001971 sulfate 1 binding site; other site 272623001972 glycogen synthase; Provisional; Region: glgA; PRK00654 272623001973 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272623001974 ADP-binding pocket [chemical binding]; other site 272623001975 homodimer interface [polypeptide binding]; other site 272623001976 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272623001977 homodimer interface [polypeptide binding]; other site 272623001978 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272623001979 active site pocket [active] 272623001980 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 272623001981 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272623001982 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272623001983 active site 272623001984 homodimer interface [polypeptide binding]; other site 272623001985 catalytic site [active] 272623001986 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272623001987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001988 putative substrate translocation pore; other site 272623001989 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623001990 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623001991 Integrase core domain; Region: rve; pfam00665 272623001992 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272623001993 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272623001994 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272623001995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623001996 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272623001997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623001998 Walker A/P-loop; other site 272623001999 ATP binding site [chemical binding]; other site 272623002000 Q-loop/lid; other site 272623002001 ABC transporter signature motif; other site 272623002002 Walker B; other site 272623002003 D-loop; other site 272623002004 H-loop/switch region; other site 272623002005 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272623002006 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 272623002007 Walker A/P-loop; other site 272623002008 ATP binding site [chemical binding]; other site 272623002009 Q-loop/lid; other site 272623002010 ABC transporter signature motif; other site 272623002011 Walker B; other site 272623002012 D-loop; other site 272623002013 H-loop/switch region; other site 272623002014 MarR family; Region: MarR_2; cl17246 272623002015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623002016 putative Zn2+ binding site [ion binding]; other site 272623002017 putative DNA binding site [nucleotide binding]; other site 272623002018 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 272623002019 Flavodoxin [Energy production and conversion / Coenzyme metabolism]; Region: HemG; COG4635 272623002020 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 272623002021 active site 272623002022 catalytic triad [active] 272623002023 oxyanion hole [active] 272623002024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623002025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623002026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623002027 Walker A/P-loop; other site 272623002028 ATP binding site [chemical binding]; other site 272623002029 Q-loop/lid; other site 272623002030 ABC transporter signature motif; other site 272623002031 Walker B; other site 272623002032 D-loop; other site 272623002033 H-loop/switch region; other site 272623002034 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623002035 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272623002036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623002037 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272623002038 Walker A/P-loop; other site 272623002039 ATP binding site [chemical binding]; other site 272623002040 Q-loop/lid; other site 272623002041 ABC transporter signature motif; other site 272623002042 Walker B; other site 272623002043 D-loop; other site 272623002044 H-loop/switch region; other site 272623002045 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623002046 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272623002047 FtsX-like permease family; Region: FtsX; pfam02687 272623002048 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 272623002049 Predicted membrane protein [Function unknown]; Region: COG3619 272623002050 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272623002051 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272623002052 putative NAD(P) binding site [chemical binding]; other site 272623002053 dimer interface [polypeptide binding]; other site 272623002054 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272623002055 substrate binding site [chemical binding]; other site 272623002056 THF binding site; other site 272623002057 zinc-binding site [ion binding]; other site 272623002058 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272623002059 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272623002060 active site 272623002061 metal binding site [ion binding]; metal-binding site 272623002062 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272623002063 nucleoside/Zn binding site; other site 272623002064 dimer interface [polypeptide binding]; other site 272623002065 catalytic motif [active] 272623002066 putative transposase OrfB; Reviewed; Region: PHA02517 272623002067 HTH-like domain; Region: HTH_21; pfam13276 272623002068 Integrase core domain; Region: rve; pfam00665 272623002069 Integrase core domain; Region: rve_3; pfam13683 272623002070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623002071 Transposase; Region: HTH_Tnp_1; pfam01527 272623002072 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272623002073 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272623002074 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272623002075 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623002076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623002077 DNA binding site [nucleotide binding] 272623002078 domain linker motif; other site 272623002079 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623002080 dimerization interface [polypeptide binding]; other site 272623002081 ligand binding site [chemical binding]; other site 272623002082 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272623002083 CoenzymeA binding site [chemical binding]; other site 272623002084 subunit interaction site [polypeptide binding]; other site 272623002085 PHB binding site; other site 272623002086 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 272623002087 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 272623002088 active site 272623002089 octamer interface [polypeptide binding]; other site 272623002090 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 272623002091 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 272623002092 acyl-activating enzyme (AAE) consensus motif; other site 272623002093 putative AMP binding site [chemical binding]; other site 272623002094 putative active site [active] 272623002095 putative CoA binding site [chemical binding]; other site 272623002096 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 272623002097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272623002098 substrate binding site [chemical binding]; other site 272623002099 oxyanion hole (OAH) forming residues; other site 272623002100 trimer interface [polypeptide binding]; other site 272623002101 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 272623002102 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623002103 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 272623002104 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272623002105 dimer interface [polypeptide binding]; other site 272623002106 tetramer interface [polypeptide binding]; other site 272623002107 PYR/PP interface [polypeptide binding]; other site 272623002108 TPP binding site [chemical binding]; other site 272623002109 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272623002110 TPP-binding site; other site 272623002111 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272623002112 isochorismate synthases; Region: isochor_syn; TIGR00543 272623002113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272623002114 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272623002115 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272623002116 DRTGG domain; Region: DRTGG; pfam07085 272623002117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272623002118 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272623002119 DHH family; Region: DHH; pfam01368 272623002120 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272623002121 active site 272623002122 homotetramer interface [polypeptide binding]; other site 272623002123 homodimer interface [polypeptide binding]; other site 272623002124 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272623002125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002126 active site 272623002127 motif I; other site 272623002128 motif II; other site 272623002129 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 272623002131 metal binding site [ion binding]; metal-binding site 272623002132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272623002133 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 272623002134 aspartate kinase; Reviewed; Region: PRK09034 272623002135 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272623002136 nucleotide binding site [chemical binding]; other site 272623002137 substrate binding site [chemical binding]; other site 272623002138 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272623002139 allosteric regulatory residue; other site 272623002140 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272623002141 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272623002142 Patatin-like phospholipase; Region: Patatin; pfam01734 272623002143 active site 272623002144 nucleophile elbow; other site 272623002145 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623002146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623002147 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272623002148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002149 active site 272623002150 motif I; other site 272623002151 motif II; other site 272623002152 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272623002153 DHH family; Region: DHH; pfam01368 272623002154 DHHA1 domain; Region: DHHA1; pfam02272 272623002155 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272623002156 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272623002157 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272623002158 replicative DNA helicase; Provisional; Region: PRK05748 272623002159 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272623002160 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272623002161 Walker A motif; other site 272623002162 ATP binding site [chemical binding]; other site 272623002163 Walker B motif; other site 272623002164 DNA binding loops [nucleotide binding] 272623002165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 272623002166 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 272623002167 Phosphotransferase enzyme family; Region: APH; pfam01636 272623002168 active site 272623002169 ATP binding site [chemical binding]; other site 272623002170 substrate binding site [chemical binding]; other site 272623002171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623002172 S-adenosylmethionine binding site [chemical binding]; other site 272623002173 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272623002174 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 272623002175 ATP cone domain; Region: ATP-cone; pfam03477 272623002176 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272623002177 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272623002178 primosomal protein DnaI; Reviewed; Region: PRK08939 272623002179 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272623002180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623002181 Walker A motif; other site 272623002182 ATP binding site [chemical binding]; other site 272623002183 Walker B motif; other site 272623002184 arginine finger; other site 272623002185 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272623002186 dimer interface [polypeptide binding]; other site 272623002187 FMN binding site [chemical binding]; other site 272623002188 NADPH bind site [chemical binding]; other site 272623002189 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272623002190 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272623002191 GTP-binding protein Der; Reviewed; Region: PRK00093 272623002192 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272623002193 G1 box; other site 272623002194 GTP/Mg2+ binding site [chemical binding]; other site 272623002195 Switch I region; other site 272623002196 G2 box; other site 272623002197 Switch II region; other site 272623002198 G3 box; other site 272623002199 G4 box; other site 272623002200 G5 box; other site 272623002201 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272623002202 G1 box; other site 272623002203 GTP/Mg2+ binding site [chemical binding]; other site 272623002204 Switch I region; other site 272623002205 G2 box; other site 272623002206 G3 box; other site 272623002207 Switch II region; other site 272623002208 G4 box; other site 272623002209 G5 box; other site 272623002210 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272623002211 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623002212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002213 non-specific DNA binding site [nucleotide binding]; other site 272623002214 salt bridge; other site 272623002215 sequence-specific DNA binding site [nucleotide binding]; other site 272623002216 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623002217 cytoskeletal protein RodZ; Provisional; Region: PRK10856 272623002218 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 272623002219 active site 272623002220 catalytic site [active] 272623002221 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 272623002222 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272623002223 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272623002224 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272623002225 putative oligomer interface [polypeptide binding]; other site 272623002226 putative RNA binding site [nucleotide binding]; other site 272623002227 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272623002228 NusA N-terminal domain; Region: NusA_N; pfam08529 272623002229 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272623002230 RNA binding site [nucleotide binding]; other site 272623002231 homodimer interface [polypeptide binding]; other site 272623002232 NusA-like KH domain; Region: KH_5; pfam13184 272623002233 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272623002234 G-X-X-G motif; other site 272623002235 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272623002236 putative RNA binding cleft [nucleotide binding]; other site 272623002237 hypothetical protein; Provisional; Region: PRK07283 272623002238 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623002239 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272623002240 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623002241 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272623002242 G1 box; other site 272623002243 putative GEF interaction site [polypeptide binding]; other site 272623002244 GTP/Mg2+ binding site [chemical binding]; other site 272623002245 Switch I region; other site 272623002246 G2 box; other site 272623002247 G3 box; other site 272623002248 Switch II region; other site 272623002249 G4 box; other site 272623002250 G5 box; other site 272623002251 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272623002252 Translation-initiation factor 2; Region: IF-2; pfam11987 272623002253 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272623002254 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272623002255 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272623002256 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 272623002257 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623002258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623002259 putative DNA binding site [nucleotide binding]; other site 272623002260 putative Zn2+ binding site [ion binding]; other site 272623002261 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272623002262 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272623002263 dimer interface [polypeptide binding]; other site 272623002264 active site 272623002265 CoA binding pocket [chemical binding]; other site 272623002266 acyl carrier protein; Provisional; Region: acpP; PRK00982 272623002267 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272623002268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272623002269 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272623002270 NAD(P) binding site [chemical binding]; other site 272623002271 homotetramer interface [polypeptide binding]; other site 272623002272 homodimer interface [polypeptide binding]; other site 272623002273 active site 272623002274 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272623002275 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272623002276 dimer interface [polypeptide binding]; other site 272623002277 active site 272623002278 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272623002279 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272623002280 carboxyltransferase (CT) interaction site; other site 272623002281 biotinylation site [posttranslational modification]; other site 272623002282 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272623002283 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272623002284 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623002285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272623002286 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 272623002287 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272623002288 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 272623002289 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623002290 homodimer interface [polypeptide binding]; other site 272623002291 substrate-cofactor binding pocket; other site 272623002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002293 catalytic residue [active] 272623002294 cysteine synthase; Region: PLN02565 272623002295 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272623002296 dimer interface [polypeptide binding]; other site 272623002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002298 catalytic residue [active] 272623002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 272623002300 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623002301 active site residue [active] 272623002302 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623002303 active site residue [active] 272623002304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623002305 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 272623002306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002307 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623002308 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 272623002309 active site residue [active] 272623002310 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 272623002311 putative homodimer interface [polypeptide binding]; other site 272623002312 putative homotetramer interface [polypeptide binding]; other site 272623002313 putative metal binding site [ion binding]; other site 272623002314 putative homodimer-homodimer interface [polypeptide binding]; other site 272623002315 putative allosteric switch controlling residues; other site 272623002316 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272623002317 putative ArsC-like catalytic residues; other site 272623002318 putative TRX-like catalytic residues [active] 272623002319 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623002320 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272623002321 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272623002322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272623002323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272623002324 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272623002325 active site 272623002326 putative catalytic site [active] 272623002327 DNA binding site [nucleotide binding] 272623002328 putative phosphate binding site [ion binding]; other site 272623002329 metal binding site A [ion binding]; metal-binding site 272623002330 AP binding site [nucleotide binding]; other site 272623002331 metal binding site B [ion binding]; metal-binding site 272623002332 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272623002333 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272623002334 active site 272623002335 HIGH motif; other site 272623002336 KMSKS motif; other site 272623002337 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272623002338 tRNA binding surface [nucleotide binding]; other site 272623002339 anticodon binding site; other site 272623002340 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272623002341 dimer interface [polypeptide binding]; other site 272623002342 putative tRNA-binding site [nucleotide binding]; other site 272623002343 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 272623002344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272623002345 classical (c) SDRs; Region: SDR_c; cd05233 272623002346 NAD(P) binding site [chemical binding]; other site 272623002347 active site 272623002348 Predicted membrane protein [Function unknown]; Region: COG4708 272623002349 Putative NADH-flavin reductase [General function prediction only]; Region: COG2910 272623002350 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272623002351 NAD(P) binding site [chemical binding]; other site 272623002352 active site 272623002353 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 272623002354 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272623002355 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272623002356 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272623002357 heterotetramer interface [polypeptide binding]; other site 272623002358 active site pocket [active] 272623002359 cleavage site 272623002360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272623002361 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272623002362 inhibitor-cofactor binding pocket; inhibition site 272623002363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002364 catalytic residue [active] 272623002365 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272623002366 feedback inhibition sensing region; other site 272623002367 homohexameric interface [polypeptide binding]; other site 272623002368 nucleotide binding site [chemical binding]; other site 272623002369 N-acetyl-L-glutamate binding site [chemical binding]; other site 272623002370 ornithine carbamoyltransferase; Validated; Region: PRK02102 272623002371 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623002372 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272623002373 ribonuclease III; Reviewed; Region: rnc; PRK00102 272623002374 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272623002375 dimerization interface [polypeptide binding]; other site 272623002376 active site 272623002377 metal binding site [ion binding]; metal-binding site 272623002378 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272623002379 dsRNA binding site [nucleotide binding]; other site 272623002380 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272623002381 Sulfatase; Region: Sulfatase; cl19157 272623002382 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272623002383 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272623002384 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623002385 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272623002386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002387 active site 272623002388 motif I; other site 272623002389 motif II; other site 272623002390 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623002391 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 272623002392 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272623002393 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272623002394 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272623002395 P loop; other site 272623002396 GTP binding site [chemical binding]; other site 272623002397 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 272623002398 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272623002399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623002400 active site 272623002401 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272623002402 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272623002403 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272623002404 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272623002405 active site 272623002406 HIGH motif; other site 272623002407 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272623002408 KMSKS motif; other site 272623002409 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272623002410 tRNA binding surface [nucleotide binding]; other site 272623002411 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272623002412 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623002413 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623002414 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623002415 putative active site [active] 272623002416 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272623002417 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623002418 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272623002419 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272623002420 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623002421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623002422 HTH-like domain; Region: HTH_21; pfam13276 272623002423 Integrase core domain; Region: rve; pfam00665 272623002424 Integrase core domain; Region: rve_3; pfam13683 272623002425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623002426 Transposase; Region: HTH_Tnp_1; pfam01527 272623002427 putative transposase OrfB; Reviewed; Region: PHA02517 272623002428 HTH-like domain; Region: HTH_21; pfam13276 272623002429 Integrase core domain; Region: rve; pfam00665 272623002430 Integrase core domain; Region: rve_2; pfam13333 272623002431 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623002432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623002433 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623002434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623002435 Transposase; Region: HTH_Tnp_1; pfam01527 272623002436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623002437 HTH-like domain; Region: HTH_21; pfam13276 272623002438 Integrase core domain; Region: rve; pfam00665 272623002439 Integrase core domain; Region: rve_3; pfam13683 272623002440 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272623002441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272623002442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002443 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272623002444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002445 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272623002446 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272623002447 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272623002448 putative L-serine binding site [chemical binding]; other site 272623002449 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272623002450 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272623002451 Predicted transcriptional regulator [Transcription]; Region: COG3682 272623002452 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623002453 metal-binding site [ion binding] 272623002454 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272623002455 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623002456 metal-binding site [ion binding] 272623002457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623002458 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272623002459 Predicted membrane protein [Function unknown]; Region: COG4485 272623002460 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272623002461 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272623002462 nucleotide binding site/active site [active] 272623002463 HIT family signature motif; other site 272623002464 catalytic residue [active] 272623002465 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272623002466 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272623002467 Ligand Binding Site [chemical binding]; other site 272623002468 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272623002469 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623002470 RNA binding site [nucleotide binding]; other site 272623002471 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272623002472 RNA binding site [nucleotide binding]; other site 272623002473 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272623002474 RNA binding site [nucleotide binding]; other site 272623002475 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 272623002476 RNA binding site [nucleotide binding]; other site 272623002477 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272623002478 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272623002479 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272623002480 GIY-YIG motif/motif A; other site 272623002481 active site 272623002482 catalytic site [active] 272623002483 putative DNA binding site [nucleotide binding]; other site 272623002484 metal binding site [ion binding]; metal-binding site 272623002485 UvrB/uvrC motif; Region: UVR; pfam02151 272623002486 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272623002487 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272623002488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272623002489 minor groove reading motif; other site 272623002490 helix-hairpin-helix signature motif; other site 272623002491 substrate binding pocket [chemical binding]; other site 272623002492 active site 272623002493 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272623002494 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272623002495 DNA binding and oxoG recognition site [nucleotide binding] 272623002496 dipeptidase PepV; Region: dipeptidase; TIGR01886 272623002497 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272623002498 active site 272623002499 metal binding site [ion binding]; metal-binding site 272623002500 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272623002501 alanine racemase; Reviewed; Region: alr; PRK00053 272623002502 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272623002503 active site 272623002504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623002505 dimer interface [polypeptide binding]; other site 272623002506 substrate binding site [chemical binding]; other site 272623002507 catalytic residues [active] 272623002508 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623002509 putative catalytic residues [active] 272623002510 thiol/disulfide switch; other site 272623002511 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272623002512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002513 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623002514 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272623002515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623002516 Walker A/P-loop; other site 272623002517 ATP binding site [chemical binding]; other site 272623002518 Q-loop/lid; other site 272623002519 ABC transporter signature motif; other site 272623002520 Walker B; other site 272623002521 D-loop; other site 272623002522 H-loop/switch region; other site 272623002523 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272623002524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623002525 dimer interface [polypeptide binding]; other site 272623002526 conserved gate region; other site 272623002527 putative PBP binding loops; other site 272623002528 ABC-ATPase subunit interface; other site 272623002529 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272623002530 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272623002531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623002532 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272623002533 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272623002534 putative minor structural protein; Region: PHA01351 272623002535 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 272623002536 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272623002537 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272623002538 homodimer interface [polypeptide binding]; other site 272623002539 NADP binding site [chemical binding]; other site 272623002540 substrate binding site [chemical binding]; other site 272623002541 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272623002542 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272623002543 generic binding surface II; other site 272623002544 generic binding surface I; other site 272623002545 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 272623002546 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272623002547 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623002548 substrate binding pocket [chemical binding]; other site 272623002549 chain length determination region; other site 272623002550 substrate-Mg2+ binding site; other site 272623002551 catalytic residues [active] 272623002552 aspartate-rich region 1; other site 272623002553 active site lid residues [active] 272623002554 aspartate-rich region 2; other site 272623002555 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272623002556 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272623002557 Arginine repressor [Transcription]; Region: ArgR; COG1438 272623002558 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272623002559 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272623002560 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272623002561 Walker A/P-loop; other site 272623002562 ATP binding site [chemical binding]; other site 272623002563 Q-loop/lid; other site 272623002564 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272623002565 ABC transporter signature motif; other site 272623002566 Walker B; other site 272623002567 D-loop; other site 272623002568 H-loop/switch region; other site 272623002569 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623002570 Predicted membrane protein [Function unknown]; Region: COG3152 272623002571 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272623002572 Predicted membrane protein [Function unknown]; Region: COG3152 272623002573 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272623002574 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 272623002575 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272623002576 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272623002577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272623002578 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272623002579 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272623002580 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272623002581 Mg++ binding site [ion binding]; other site 272623002582 putative catalytic motif [active] 272623002583 putative substrate binding site [chemical binding]; other site 272623002584 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623002585 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272623002586 FtsX-like permease family; Region: FtsX; pfam02687 272623002587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623002588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623002589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623002590 dimerization interface [polypeptide binding]; other site 272623002591 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623002592 synthetase active site [active] 272623002593 NTP binding site [chemical binding]; other site 272623002594 metal binding site [ion binding]; metal-binding site 272623002595 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272623002596 N-glycosyltransferase; Provisional; Region: PRK11204 272623002597 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272623002598 DXD motif; other site 272623002599 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272623002600 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 272623002601 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623002602 Ligand Binding Site [chemical binding]; other site 272623002603 histone-like DNA-binding protein HU; Region: HU; cd13831 272623002604 dimer interface [polypeptide binding]; other site 272623002605 DNA binding site [nucleotide binding] 272623002606 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272623002607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623002608 Predicted membrane protein [Function unknown]; Region: COG1511 272623002609 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272623002610 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272623002611 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272623002612 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272623002613 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 272623002614 Predicted membrane protein [Function unknown]; Region: COG4758 272623002615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272623002616 Histidine kinase; Region: HisKA_3; pfam07730 272623002617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002618 ATP binding site [chemical binding]; other site 272623002619 Mg2+ binding site [ion binding]; other site 272623002620 G-X-G motif; other site 272623002621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272623002622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623002623 active site 272623002624 phosphorylation site [posttranslational modification] 272623002625 intermolecular recognition site; other site 272623002626 dimerization interface [polypeptide binding]; other site 272623002627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272623002628 DNA binding residues [nucleotide binding] 272623002629 dimerization interface [polypeptide binding]; other site 272623002630 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272623002631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002632 active site 272623002633 motif I; other site 272623002634 motif II; other site 272623002635 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623002636 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272623002637 active site 272623002638 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 272623002639 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623002640 RNA binding site [nucleotide binding]; other site 272623002641 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272623002642 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272623002643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272623002644 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 272623002645 putative NAD(P) binding site [chemical binding]; other site 272623002646 catalytic Zn binding site [ion binding]; other site 272623002647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002648 acetoin reductase; Validated; Region: PRK08643 272623002649 NAD(P) binding site [chemical binding]; other site 272623002650 active site 272623002651 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623002652 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623002654 ABC transporter; Region: ABC_tran_2; pfam12848 272623002655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623002656 malate dehydrogenase; Provisional; Region: PRK13529 272623002657 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272623002658 Malic enzyme, NAD binding domain; Region: Malic_M; pfam03949 272623002659 NAD(P) binding pocket [chemical binding]; other site 272623002660 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 272623002661 EamA-like transporter family; Region: EamA; pfam00892 272623002662 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272623002663 EamA-like transporter family; Region: EamA; pfam00892 272623002664 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272623002665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002666 motif II; other site 272623002667 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272623002668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002669 ATP binding site [chemical binding]; other site 272623002670 Mg2+ binding site [ion binding]; other site 272623002671 G-X-G motif; other site 272623002672 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272623002673 anchoring element; other site 272623002674 dimer interface [polypeptide binding]; other site 272623002675 ATP binding site [chemical binding]; other site 272623002676 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272623002677 active site 272623002678 putative metal-binding site [ion binding]; other site 272623002679 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272623002680 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272623002681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623002682 S-adenosylmethionine binding site [chemical binding]; other site 272623002683 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623002684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623002685 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623002686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623002687 putative substrate translocation pore; other site 272623002688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623002689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002690 non-specific DNA binding site [nucleotide binding]; other site 272623002691 salt bridge; other site 272623002692 sequence-specific DNA binding site [nucleotide binding]; other site 272623002693 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 272623002694 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272623002695 Ion channel; Region: Ion_trans_2; pfam07885 272623002696 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272623002697 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272623002698 Walker A/P-loop; other site 272623002699 ATP binding site [chemical binding]; other site 272623002700 Q-loop/lid; other site 272623002701 ABC transporter signature motif; other site 272623002702 Walker B; other site 272623002703 D-loop; other site 272623002704 H-loop/switch region; other site 272623002705 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272623002706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623002707 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272623002708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623002709 active site 272623002710 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002711 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002712 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002713 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272623002715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272623002716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623002717 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 272623002718 active site 272623002719 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002720 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002721 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002722 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002723 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272623002724 phosphopentomutase; Provisional; Region: PRK05362 272623002725 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 272623002726 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 272623002727 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623002728 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623002729 Integrase core domain; Region: rve; pfam00665 272623002730 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272623002731 hypothetical protein; Provisional; Region: PRK00967 272623002732 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272623002733 Potassium binding sites [ion binding]; other site 272623002734 Cesium cation binding sites [ion binding]; other site 272623002735 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623002736 NlpC/P60 family; Region: NLPC_P60; pfam00877 272623002737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623002738 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623002739 substrate binding pocket [chemical binding]; other site 272623002740 membrane-bound complex binding site; other site 272623002741 hinge residues; other site 272623002742 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272623002743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623002744 dimer interface [polypeptide binding]; other site 272623002745 conserved gate region; other site 272623002746 putative PBP binding loops; other site 272623002747 ABC-ATPase subunit interface; other site 272623002748 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623002749 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272623002750 Walker A/P-loop; other site 272623002751 ATP binding site [chemical binding]; other site 272623002752 Q-loop/lid; other site 272623002753 ABC transporter signature motif; other site 272623002754 Walker B; other site 272623002755 D-loop; other site 272623002756 H-loop/switch region; other site 272623002757 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 272623002758 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272623002759 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623002760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002761 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272623002762 ribonuclease R; Region: RNase_R; TIGR02063 272623002763 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272623002764 RNB domain; Region: RNB; pfam00773 272623002765 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272623002766 RNA binding site [nucleotide binding]; other site 272623002767 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623002768 catalytic triad [active] 272623002769 conserved cis-peptide bond; other site 272623002770 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272623002771 putative catalytic site [active] 272623002772 putative metal binding site [ion binding]; other site 272623002773 putative phosphate binding site [ion binding]; other site 272623002774 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 272623002775 putative active site [active] 272623002776 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 272623002777 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 272623002778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623002779 catalytic core [active] 272623002780 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272623002781 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272623002782 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 272623002783 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272623002784 HrcA protein C terminal domain; Region: HrcA; pfam01628 272623002785 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272623002786 dimer interface [polypeptide binding]; other site 272623002787 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272623002788 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272623002789 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272623002790 nucleotide binding site [chemical binding]; other site 272623002791 NEF interaction site [polypeptide binding]; other site 272623002792 SBD interface [polypeptide binding]; other site 272623002793 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 272623002794 myosin-cross-reactive antigen; Provisional; Region: PRK13977 272623002795 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272623002796 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 272623002797 metal binding site [ion binding]; metal-binding site 272623002798 dimer interface [polypeptide binding]; other site 272623002799 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623002800 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272623002801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272623002802 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272623002803 putative substrate binding site [chemical binding]; other site 272623002804 putative ATP binding site [chemical binding]; other site 272623002805 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272623002806 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272623002807 active site 272623002808 phosphorylation site [posttranslational modification] 272623002809 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272623002810 active site 272623002811 P-loop; other site 272623002812 phosphorylation site [posttranslational modification] 272623002813 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272623002814 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272623002815 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272623002816 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272623002817 putative active site [active] 272623002818 catalytic site [active] 272623002819 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272623002820 putative active site [active] 272623002821 catalytic site [active] 272623002822 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 272623002823 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 272623002824 phosphate binding site [ion binding]; other site 272623002825 dimer interface [polypeptide binding]; other site 272623002826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272623002827 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272623002828 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 272623002829 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272623002830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623002831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623002832 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272623002833 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272623002834 Walker A/P-loop; other site 272623002835 ATP binding site [chemical binding]; other site 272623002836 Q-loop/lid; other site 272623002837 ABC transporter signature motif; other site 272623002838 Walker B; other site 272623002839 D-loop; other site 272623002840 H-loop/switch region; other site 272623002841 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272623002842 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 272623002843 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272623002844 hypothetical protein; Provisional; Region: PRK13662 272623002845 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272623002846 putative phosphoesterase; Region: acc_ester; TIGR03729 272623002847 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272623002848 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272623002849 RF-1 domain; Region: RF-1; pfam00472 272623002850 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272623002851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623002852 Walker A/P-loop; other site 272623002853 ATP binding site [chemical binding]; other site 272623002854 Q-loop/lid; other site 272623002855 ABC transporter signature motif; other site 272623002856 Walker B; other site 272623002857 D-loop; other site 272623002858 H-loop/switch region; other site 272623002859 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272623002860 HD domain; Region: HD_3; cl17350 272623002861 FtsX-like permease family; Region: FtsX; pfam02687 272623002862 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272623002863 dimer interface [polypeptide binding]; other site 272623002864 putative radical transfer pathway; other site 272623002865 diiron center [ion binding]; other site 272623002866 tyrosyl radical; other site 272623002867 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 272623002868 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272623002869 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272623002870 active site 272623002871 dimer interface [polypeptide binding]; other site 272623002872 catalytic residues [active] 272623002873 effector binding site; other site 272623002874 R2 peptide binding site; other site 272623002875 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 272623002876 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272623002877 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272623002878 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 272623002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002880 ATP binding site [chemical binding]; other site 272623002881 Mg2+ binding site [ion binding]; other site 272623002882 G-X-G motif; other site 272623002883 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272623002884 anchoring element; other site 272623002885 dimer interface [polypeptide binding]; other site 272623002886 ATP binding site [chemical binding]; other site 272623002887 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272623002888 active site 272623002889 metal binding site [ion binding]; metal-binding site 272623002890 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272623002891 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272623002892 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623002893 catalytic triad [active] 272623002894 conserved cis-peptide bond; other site 272623002895 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272623002896 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623002897 active site 272623002898 catalytic site [active] 272623002899 substrate binding site [chemical binding]; other site 272623002900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623002901 Coenzyme A binding pocket [chemical binding]; other site 272623002902 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 272623002903 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272623002904 CAP-like domain; other site 272623002905 active site 272623002906 primary dimer interface [polypeptide binding]; other site 272623002907 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623002908 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623002909 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272623002910 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272623002911 oligomer interface [polypeptide binding]; other site 272623002912 Cl binding site [ion binding]; other site 272623002913 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272623002914 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272623002915 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272623002916 catalytic motif [active] 272623002917 Zn binding site [ion binding]; other site 272623002918 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272623002919 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272623002920 Lumazine binding domain; Region: Lum_binding; pfam00677 272623002921 Lumazine binding domain; Region: Lum_binding; pfam00677 272623002922 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272623002923 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272623002924 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272623002925 dimerization interface [polypeptide binding]; other site 272623002926 active site 272623002927 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272623002928 homopentamer interface [polypeptide binding]; other site 272623002929 active site 272623002930 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 272623002931 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272623002932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623002933 RNA binding surface [nucleotide binding]; other site 272623002934 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272623002935 active site 272623002936 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272623002937 active site 272623002938 conserved hypothetical integral membrane protein; Region: TIGR03766 272623002939 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272623002940 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272623002941 Ligand binding site; other site 272623002942 Putative Catalytic site; other site 272623002943 DXD motif; other site 272623002944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623002946 active site 272623002947 phosphorylation site [posttranslational modification] 272623002948 intermolecular recognition site; other site 272623002949 dimerization interface [polypeptide binding]; other site 272623002950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623002951 DNA binding site [nucleotide binding] 272623002952 Predicted membrane protein [Function unknown]; Region: COG4331 272623002953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623002954 HAMP domain; Region: HAMP; pfam00672 272623002955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623002956 dimer interface [polypeptide binding]; other site 272623002957 phosphorylation site [posttranslational modification] 272623002958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002959 ATP binding site [chemical binding]; other site 272623002960 Mg2+ binding site [ion binding]; other site 272623002961 G-X-G motif; other site 272623002962 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272623002963 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272623002964 active site 272623002965 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272623002966 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272623002967 glutaminase active site [active] 272623002968 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272623002969 dimer interface [polypeptide binding]; other site 272623002970 active site 272623002971 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272623002972 dimer interface [polypeptide binding]; other site 272623002973 active site 272623002974 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 272623002975 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272623002976 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272623002977 MPN+ (JAMM) motif; other site 272623002978 Zinc-binding site [ion binding]; other site 272623002979 Bacteriophage bIL285 272623002980 integrase; Provisional; Region: int; PHA02601 272623002981 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 272623002982 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272623002983 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623002984 Int/Topo IB signature motif; other site 272623002985 Bacterial PH domain; Region: bPH_3; pfam14470 272623002986 Short C-terminal domain; Region: SHOCT; pfam09851 272623002987 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272623002988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002989 non-specific DNA binding site [nucleotide binding]; other site 272623002990 salt bridge; other site 272623002991 sequence-specific DNA binding site [nucleotide binding]; other site 272623002992 Protein of unknown function (DUF739); Region: DUF739; pfam05339 272623002993 ORF6N domain; Region: ORF6N; pfam10543 272623002994 ORF6C domain; Region: ORF6C; pfam10552 272623002995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 272623002996 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 272623002997 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 272623002998 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 272623002999 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272623003000 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623003001 dimer interface [polypeptide binding]; other site 272623003002 ssDNA binding site [nucleotide binding]; other site 272623003003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003004 Putative replisome organizer protein C-terminus; Region: Rep_Org_C; pfam06926 272623003005 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 272623003006 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272623003007 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272623003008 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623003009 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272623003010 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623003011 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623003012 trimer interface [polypeptide binding]; other site 272623003013 active site 272623003014 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623003015 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623003016 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623003017 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272623003018 Phage terminase, small subunit; Region: Terminase_4; cl01525 272623003019 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623003020 Phage Terminase; Region: Terminase_1; cl19862 272623003021 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 272623003022 Phage head maturation protease [General function prediction only]; Region: COG3740 272623003023 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 272623003024 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272623003025 Phage capsid family; Region: Phage_capsid; pfam05065 272623003026 phage head-tail adaptor, putative, SPP1 family; Region: gp16_SPP1; TIGR01563 272623003027 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 272623003028 Phage-related minor tail protein [Function unknown]; Region: COG5280 272623003029 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 272623003030 Phage-related protein [Function unknown]; Region: COG4722 272623003031 Phage-related protein [Function unknown]; Region: PblB; COG4926 272623003032 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272623003033 Peptidase family M23; Region: Peptidase_M23; pfam01551 272623003034 Haemolysin XhlA; Region: XhlA; pfam10779 272623003035 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 272623003036 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272623003037 CoA binding domain; Region: CoA_binding; pfam02629 272623003038 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623003039 putative catalytic residues [active] 272623003040 thiol/disulfide switch; other site 272623003041 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623003042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623003043 ABC transporter; Region: ABC_tran_2; pfam12848 272623003044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623003045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003046 non-specific DNA binding site [nucleotide binding]; other site 272623003047 salt bridge; other site 272623003048 sequence-specific DNA binding site [nucleotide binding]; other site 272623003049 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623003050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623003051 active site 272623003052 dihydroorotase; Validated; Region: pyrC; PRK09357 272623003053 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272623003054 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272623003055 active site 272623003056 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272623003057 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272623003058 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272623003059 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272623003060 minor groove reading motif; other site 272623003061 helix-hairpin-helix signature motif; other site 272623003062 substrate binding pocket [chemical binding]; other site 272623003063 active site 272623003064 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 272623003065 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272623003066 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272623003067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 272623003068 sugar phosphate phosphatase; Provisional; Region: PRK10513 272623003069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623003070 active site 272623003071 motif I; other site 272623003072 motif II; other site 272623003073 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623003074 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272623003075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623003076 Zn2+ binding site [ion binding]; other site 272623003077 Mg2+ binding site [ion binding]; other site 272623003078 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 272623003079 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 272623003080 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272623003081 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272623003082 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 272623003083 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272623003084 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272623003085 PhoH-like protein; Region: PhoH; pfam02562 272623003086 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272623003087 nudix motif; other site 272623003088 metal-binding heat shock protein; Provisional; Region: PRK00016 272623003089 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 272623003090 trimer interface [polypeptide binding]; other site 272623003091 putative active site [active] 272623003092 Zn binding site [ion binding]; other site 272623003093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 272623003094 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272623003095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623003096 active site 272623003097 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272623003098 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 272623003099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623003100 nucleotide binding region [chemical binding]; other site 272623003101 ATP-binding site [chemical binding]; other site 272623003102 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272623003103 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272623003104 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272623003105 VanZ like family; Region: VanZ; pfam04892 272623003106 hypothetical protein; Provisional; Region: PRK14013 272623003107 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272623003108 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272623003109 active site 272623003110 metal binding site [ion binding]; metal-binding site 272623003111 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 272623003112 motif 1; other site 272623003113 dimer interface [polypeptide binding]; other site 272623003114 active site 272623003115 motif 2; other site 272623003116 motif 3; other site 272623003117 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 272623003118 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272623003119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272623003120 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272623003121 putative Cl- selectivity filter; other site 272623003122 putative pore gating glutamate residue; other site 272623003123 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272623003124 active site 272623003125 (T/H)XGH motif; other site 272623003126 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272623003127 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272623003128 active site 272623003129 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623003130 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 272623003131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623003132 Coenzyme A binding pocket [chemical binding]; other site 272623003133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272623003134 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272623003135 homodimer interface [polypeptide binding]; other site 272623003136 NAD binding pocket [chemical binding]; other site 272623003137 ATP binding pocket [chemical binding]; other site 272623003138 Mg binding site [ion binding]; other site 272623003139 active-site loop [active] 272623003140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623003141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272623003142 Walker A/P-loop; other site 272623003143 ATP binding site [chemical binding]; other site 272623003144 Q-loop/lid; other site 272623003145 ABC transporter signature motif; other site 272623003146 Walker B; other site 272623003147 D-loop; other site 272623003148 H-loop/switch region; other site 272623003149 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272623003150 FtsX-like permease family; Region: FtsX; pfam02687 272623003151 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623003152 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272623003153 FtsX-like permease family; Region: FtsX; pfam02687 272623003154 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272623003155 catalytic triad [active] 272623003156 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272623003157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623003158 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272623003159 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 272623003160 GTP-binding protein LepA; Provisional; Region: PRK05433 272623003161 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272623003162 G1 box; other site 272623003163 putative GEF interaction site [polypeptide binding]; other site 272623003164 GTP/Mg2+ binding site [chemical binding]; other site 272623003165 Switch I region; other site 272623003166 G2 box; other site 272623003167 G3 box; other site 272623003168 Switch II region; other site 272623003169 G4 box; other site 272623003170 G5 box; other site 272623003171 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272623003172 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272623003173 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272623003174 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272623003175 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272623003176 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272623003177 NAD(P) binding site [chemical binding]; other site 272623003178 putative active site [active] 272623003179 Amino acid permease; Region: AA_permease_2; pfam13520 272623003180 DNA gyrase subunit A; Validated; Region: PRK05560 272623003181 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272623003182 CAP-like domain; other site 272623003183 active site 272623003184 primary dimer interface [polypeptide binding]; other site 272623003185 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003191 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272623003192 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 272623003193 active site 272623003194 catalytic site [active] 272623003195 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272623003196 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 272623003197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623003198 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272623003199 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 272623003200 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 272623003201 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272623003202 dimer interface [polypeptide binding]; other site 272623003203 putative anticodon binding site; other site 272623003204 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272623003205 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272623003206 Part of AAA domain; Region: AAA_19; pfam13245 272623003207 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272623003208 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272623003209 putative active site [active] 272623003210 nucleotide binding site [chemical binding]; other site 272623003211 nudix motif; other site 272623003212 putative metal binding site [ion binding]; other site 272623003213 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272623003214 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272623003215 dimer interface [polypeptide binding]; other site 272623003216 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 272623003217 L-aspartate oxidase; Provisional; Region: PRK06175 272623003218 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 272623003219 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272623003220 RNA binding site [nucleotide binding]; other site 272623003221 active site 272623003222 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272623003223 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272623003224 active site 272623003225 Riboflavin kinase; Region: Flavokinase; smart00904 272623003226 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623003227 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623003228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003229 NAD binding site [chemical binding]; other site 272623003230 dimer interface [polypeptide binding]; other site 272623003231 substrate binding site [chemical binding]; other site 272623003232 Uncharacterized conserved protein [Function unknown]; Region: COG3589 272623003233 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 272623003234 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272623003235 putative active site [active] 272623003236 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623003237 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 272623003238 active site turn [active] 272623003239 phosphorylation site [posttranslational modification] 272623003240 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272623003241 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272623003242 HPr interaction site; other site 272623003243 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623003244 active site 272623003245 phosphorylation site [posttranslational modification] 272623003246 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623003247 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623003248 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623003249 putative active site [active] 272623003250 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272623003251 substrate binding site [chemical binding]; other site 272623003252 dimer interface [polypeptide binding]; other site 272623003253 catalytic triad [active] 272623003254 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272623003255 active site 272623003256 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 272623003257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272623003258 Active Sites [active] 272623003259 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 272623003260 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272623003261 ParB-like nuclease domain; Region: ParBc; pfam02195 272623003262 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 272623003263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623003264 FeS/SAM binding site; other site 272623003265 HemN C-terminal domain; Region: HemN_C; pfam06969 272623003266 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 272623003267 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 272623003268 active site 272623003269 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272623003270 catalytic motif [active] 272623003271 Zn binding site [ion binding]; other site 272623003272 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272623003273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623003274 active site 272623003275 motif I; other site 272623003276 motif II; other site 272623003277 Predicted membrane protein [Function unknown]; Region: COG4478 272623003278 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272623003279 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272623003280 active site 272623003281 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623003282 active site 272623003283 Sulfate transporter family; Region: Sulfate_transp; cl19250 272623003284 xanthine permease; Region: pbuX; TIGR03173 272623003285 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272623003286 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272623003287 folate binding site [chemical binding]; other site 272623003288 NADP+ binding site [chemical binding]; other site 272623003289 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272623003290 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272623003291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623003292 Walker A motif; other site 272623003293 ATP binding site [chemical binding]; other site 272623003294 Walker B motif; other site 272623003295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272623003296 Predicted GTPase [General function prediction only]; Region: COG0218 272623003297 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272623003298 G1 box; other site 272623003299 GTP/Mg2+ binding site [chemical binding]; other site 272623003300 Switch I region; other site 272623003301 G2 box; other site 272623003302 G3 box; other site 272623003303 Switch II region; other site 272623003304 G4 box; other site 272623003305 G5 box; other site 272623003306 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 272623003307 active site 272623003308 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272623003309 catalytic center binding site [active] 272623003310 ATP binding site [chemical binding]; other site 272623003311 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 272623003312 active site 272623003313 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272623003314 dihydropteroate synthase; Region: DHPS; TIGR01496 272623003315 substrate binding pocket [chemical binding]; other site 272623003316 dimer interface [polypeptide binding]; other site 272623003317 inhibitor binding site; inhibition site 272623003318 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272623003319 nudix motif; other site 272623003320 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272623003321 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623003322 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623003323 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272623003324 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272623003325 Substrate-binding site [chemical binding]; other site 272623003326 Substrate specificity [chemical binding]; other site 272623003327 homoserine dehydrogenase; Provisional; Region: PRK06349 272623003328 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272623003329 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272623003330 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272623003331 homoserine kinase; Provisional; Region: PRK01212 272623003332 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272623003333 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623003334 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272623003335 FAD binding domain; Region: FAD_binding_4; pfam01565 272623003336 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272623003337 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272623003338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623003339 Walker A/P-loop; other site 272623003340 ATP binding site [chemical binding]; other site 272623003341 Q-loop/lid; other site 272623003342 ABC transporter signature motif; other site 272623003343 Walker B; other site 272623003344 D-loop; other site 272623003345 H-loop/switch region; other site 272623003346 TOBE domain; Region: TOBE_2; pfam08402 272623003347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623003348 dimer interface [polypeptide binding]; other site 272623003349 conserved gate region; other site 272623003350 putative PBP binding loops; other site 272623003351 ABC-ATPase subunit interface; other site 272623003352 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272623003353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623003354 dimer interface [polypeptide binding]; other site 272623003355 conserved gate region; other site 272623003356 putative PBP binding loops; other site 272623003357 ABC-ATPase subunit interface; other site 272623003358 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272623003359 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272623003360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623003361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003362 non-specific DNA binding site [nucleotide binding]; other site 272623003363 salt bridge; other site 272623003364 sequence-specific DNA binding site [nucleotide binding]; other site 272623003365 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623003366 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272623003367 B12 binding site [chemical binding]; other site 272623003368 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272623003369 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272623003370 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 272623003371 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272623003372 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272623003373 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272623003374 putative active site [active] 272623003375 catalytic site [active] 272623003376 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272623003377 putative active site [active] 272623003378 catalytic site [active] 272623003379 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272623003380 putative active site cavity [active] 272623003381 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623003382 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623003383 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623003384 putative active site [active] 272623003385 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272623003386 TRAM domain; Region: TRAM; cl01282 272623003387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003388 S-adenosylmethionine binding site [chemical binding]; other site 272623003389 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272623003390 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272623003391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003392 S-adenosylmethionine binding site [chemical binding]; other site 272623003393 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272623003394 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272623003395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003396 binding surface 272623003397 TPR motif; other site 272623003398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003399 binding surface 272623003400 TPR motif; other site 272623003401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003402 binding surface 272623003403 TPR motif; other site 272623003404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003405 binding surface 272623003406 TPR motif; other site 272623003407 acetolactate synthase; Reviewed; Region: PRK08617 272623003408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272623003409 PYR/PP interface [polypeptide binding]; other site 272623003410 dimer interface [polypeptide binding]; other site 272623003411 TPP binding site [chemical binding]; other site 272623003412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272623003413 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272623003414 TPP-binding site [chemical binding]; other site 272623003415 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 272623003416 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272623003417 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 272623003418 NAD(P) binding pocket [chemical binding]; other site 272623003419 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272623003420 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272623003421 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 272623003422 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 272623003423 putative active site [active] 272623003424 (T/H)XGH motif; other site 272623003425 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 272623003426 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272623003427 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 272623003428 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 272623003429 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 272623003430 Membrane transport protein; Region: Mem_trans; cl09117 272623003431 putative transposase OrfB; Reviewed; Region: PHA02517 272623003432 HTH-like domain; Region: HTH_21; pfam13276 272623003433 Integrase core domain; Region: rve; pfam00665 272623003434 Integrase core domain; Region: rve_3; pfam13683 272623003435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623003436 Transposase; Region: HTH_Tnp_1; pfam01527 272623003437 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272623003438 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272623003439 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623003440 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003441 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623003443 Transposase; Region: HTH_Tnp_1; pfam01527 272623003444 similar to transposase of IS981C; tra981F 272623003445 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623003446 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623003447 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272623003448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272623003449 ribonuclease R; Region: RNase_R; TIGR02063 272623003450 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272623003451 RNB domain; Region: RNB; pfam00773 272623003452 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272623003453 RNA binding site [nucleotide binding]; other site 272623003454 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 272623003455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623003456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003457 homodimer interface [polypeptide binding]; other site 272623003458 catalytic residue [active] 272623003459 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 272623003460 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272623003461 dimer interface [polypeptide binding]; other site 272623003462 motif 1; other site 272623003463 active site 272623003464 motif 2; other site 272623003465 motif 3; other site 272623003466 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272623003467 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272623003468 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272623003469 histidinol dehydrogenase; Region: hisD; TIGR00069 272623003470 NAD binding site [chemical binding]; other site 272623003471 dimerization interface [polypeptide binding]; other site 272623003472 product binding site; other site 272623003473 substrate binding site [chemical binding]; other site 272623003474 zinc binding site [ion binding]; other site 272623003475 catalytic residues [active] 272623003476 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272623003477 putative active site pocket [active] 272623003478 4-fold oligomerization interface [polypeptide binding]; other site 272623003479 metal binding residues [ion binding]; metal-binding site 272623003480 3-fold/trimer interface [polypeptide binding]; other site 272623003481 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 272623003482 active site 272623003483 ATP binding site [chemical binding]; other site 272623003484 Phosphotransferase enzyme family; Region: APH; pfam01636 272623003485 antibiotic binding site [chemical binding]; other site 272623003486 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 272623003487 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272623003488 putative active site [active] 272623003489 oxyanion strand; other site 272623003490 catalytic triad [active] 272623003491 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272623003492 catalytic residues [active] 272623003493 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272623003494 substrate binding site [chemical binding]; other site 272623003495 glutamase interaction surface [polypeptide binding]; other site 272623003496 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272623003497 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272623003498 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272623003499 metal binding site [ion binding]; metal-binding site 272623003500 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 272623003501 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272623003502 active site 272623003503 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272623003504 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272623003505 active site residue [active] 272623003506 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 272623003507 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272623003508 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272623003509 substrate binding site [chemical binding]; other site 272623003510 ligand binding site [chemical binding]; other site 272623003511 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272623003512 substrate binding site [chemical binding]; other site 272623003513 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272623003514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272623003515 Walker A/P-loop; other site 272623003516 ATP binding site [chemical binding]; other site 272623003517 Q-loop/lid; other site 272623003518 ABC transporter signature motif; other site 272623003519 Walker B; other site 272623003520 D-loop; other site 272623003521 H-loop/switch region; other site 272623003522 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272623003523 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 272623003524 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272623003525 dimer interface [polypeptide binding]; other site 272623003526 PYR/PP interface [polypeptide binding]; other site 272623003527 TPP binding site [chemical binding]; other site 272623003528 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272623003529 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272623003530 TPP-binding site [chemical binding]; other site 272623003531 dimer interface [polypeptide binding]; other site 272623003532 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272623003533 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272623003534 putative valine binding site [chemical binding]; other site 272623003535 dimer interface [polypeptide binding]; other site 272623003536 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272623003537 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272623003538 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272623003539 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272623003540 threonine dehydratase; Validated; Region: PRK08639 272623003541 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272623003542 tetramer interface [polypeptide binding]; other site 272623003543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003544 catalytic residue [active] 272623003545 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 272623003546 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 272623003547 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272623003548 homotrimer interaction site [polypeptide binding]; other site 272623003549 putative active site [active] 272623003550 DNA topoisomerase I; Validated; Region: PRK05582 272623003551 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272623003552 active site 272623003553 interdomain interaction site; other site 272623003554 putative metal-binding site [ion binding]; other site 272623003555 nucleotide binding site [chemical binding]; other site 272623003556 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272623003557 domain I; other site 272623003558 DNA binding groove [nucleotide binding] 272623003559 phosphate binding site [ion binding]; other site 272623003560 domain II; other site 272623003561 domain III; other site 272623003562 nucleotide binding site [chemical binding]; other site 272623003563 catalytic site [active] 272623003564 domain IV; other site 272623003565 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272623003566 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272623003567 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272623003568 Glucose inhibited division protein A; Region: GIDA; pfam01134 272623003569 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 272623003570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623003571 active site 272623003572 DNA binding site [nucleotide binding] 272623003573 Int/Topo IB signature motif; other site 272623003574 Predicted acyl esterases [General function prediction only]; Region: COG2936 272623003575 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 272623003576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623003577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623003578 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272623003579 dimerization interface [polypeptide binding]; other site 272623003580 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272623003581 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 272623003582 putative active site [active] 272623003583 putative ligand binding site [chemical binding]; other site 272623003584 putative NAD(P) binding site [chemical binding]; other site 272623003585 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 272623003586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272623003587 Small integral membrane protein [Function unknown]; Region: COG5547 272623003588 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 272623003589 Predicted membrane protein [Function unknown]; Region: COG2261 272623003590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623003591 active site 272623003592 catalytic tetrad [active] 272623003593 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623003594 amphipathic channel; other site 272623003595 Asn-Pro-Ala signature motifs; other site 272623003596 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272623003597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623003598 glycerol kinase; Provisional; Region: glpK; PRK00047 272623003599 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272623003600 N- and C-terminal domain interface [polypeptide binding]; other site 272623003601 active site 272623003602 MgATP binding site [chemical binding]; other site 272623003603 catalytic site [active] 272623003604 metal binding site [ion binding]; metal-binding site 272623003605 glycerol binding site [chemical binding]; other site 272623003606 homotetramer interface [polypeptide binding]; other site 272623003607 homodimer interface [polypeptide binding]; other site 272623003608 FBP binding site [chemical binding]; other site 272623003609 protein IIAGlc interface [polypeptide binding]; other site 272623003610 Mga helix-turn-helix domain; Region: Mga; pfam05043 272623003611 putative transposase OrfB; Reviewed; Region: PHA02517 272623003612 HTH-like domain; Region: HTH_21; pfam13276 272623003613 Integrase core domain; Region: rve; pfam00665 272623003614 Integrase core domain; Region: rve_3; pfam13683 272623003615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623003616 Transposase; Region: HTH_Tnp_1; pfam01527 272623003617 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 272623003618 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 272623003619 active site 272623003620 Na/Ca binding site [ion binding]; other site 272623003621 catalytic site [active] 272623003622 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 272623003623 teramer interface [polypeptide binding]; other site 272623003624 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 272623003625 active site 272623003626 FMN binding site [chemical binding]; other site 272623003627 catalytic residues [active] 272623003628 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 272623003629 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272623003630 FAD binding site [chemical binding]; other site 272623003631 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272623003632 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272623003633 THF binding site; other site 272623003634 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272623003635 substrate binding site [chemical binding]; other site 272623003636 THF binding site; other site 272623003637 zinc-binding site [ion binding]; other site 272623003638 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 272623003639 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272623003640 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272623003641 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272623003642 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 272623003643 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623003644 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623003645 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272623003646 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623003647 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 272623003648 DltD N-terminal region; Region: DltD_N; pfam04915 272623003649 DltD central region; Region: DltD_M; pfam04918 272623003650 DltD C-terminal region; Region: DltD_C; pfam04914 272623003651 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 272623003652 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 272623003653 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 272623003654 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 272623003655 acyl-activating enzyme (AAE) consensus motif; other site 272623003656 AMP binding site [chemical binding]; other site 272623003657 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272623003658 thiamine phosphate binding site [chemical binding]; other site 272623003659 active site 272623003660 pyrophosphate binding site [ion binding]; other site 272623003661 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272623003662 dimer interface [polypeptide binding]; other site 272623003663 substrate binding site [chemical binding]; other site 272623003664 ATP binding site [chemical binding]; other site 272623003665 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272623003666 substrate binding site [chemical binding]; other site 272623003667 multimerization interface [polypeptide binding]; other site 272623003668 ATP binding site [chemical binding]; other site 272623003669 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272623003670 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272623003671 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 272623003672 DXD motif; other site 272623003673 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272623003674 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272623003675 active site 272623003676 homodimer interface [polypeptide binding]; other site 272623003677 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272623003678 core dimer interface [polypeptide binding]; other site 272623003679 peripheral dimer interface [polypeptide binding]; other site 272623003680 L10 interface [polypeptide binding]; other site 272623003681 L11 interface [polypeptide binding]; other site 272623003682 putative EF-Tu interaction site [polypeptide binding]; other site 272623003683 putative EF-G interaction site [polypeptide binding]; other site 272623003684 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272623003685 23S rRNA interface [nucleotide binding]; other site 272623003686 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272623003687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623003688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003689 non-specific DNA binding site [nucleotide binding]; other site 272623003690 salt bridge; other site 272623003691 sequence-specific DNA binding site [nucleotide binding]; other site 272623003692 Predicted transcriptional regulator [Transcription]; Region: COG2932 272623003693 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272623003694 Catalytic site [active] 272623003695 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623003696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623003697 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272623003698 Walker A/P-loop; other site 272623003699 ATP binding site [chemical binding]; other site 272623003700 Q-loop/lid; other site 272623003701 ABC transporter signature motif; other site 272623003702 Walker B; other site 272623003703 D-loop; other site 272623003704 H-loop/switch region; other site 272623003705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623003706 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272623003707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623003708 Walker A/P-loop; other site 272623003709 ATP binding site [chemical binding]; other site 272623003710 Q-loop/lid; other site 272623003711 ABC transporter signature motif; other site 272623003712 Walker B; other site 272623003713 D-loop; other site 272623003714 H-loop/switch region; other site 272623003715 Predicted membrane protein [Function unknown]; Region: COG3601 272623003716 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272623003717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623003718 RNA binding surface [nucleotide binding]; other site 272623003719 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272623003720 active site 272623003721 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 272623003722 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 272623003723 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 272623003724 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 272623003725 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272623003726 DNA binding site [nucleotide binding] 272623003727 FOG: CBS domain [General function prediction only]; Region: COG0517 272623003728 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272623003729 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272623003730 active site 272623003731 metal binding site [ion binding]; metal-binding site 272623003732 homotetramer interface [polypeptide binding]; other site 272623003733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 272623003734 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272623003735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272623003736 active site 272623003737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623003738 substrate binding site [chemical binding]; other site 272623003739 catalytic residues [active] 272623003740 dimer interface [polypeptide binding]; other site 272623003741 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272623003742 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272623003743 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272623003744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272623003745 NAD(P) binding site [chemical binding]; other site 272623003746 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272623003747 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272623003748 active site 272623003749 dimer interface [polypeptide binding]; other site 272623003750 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272623003751 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272623003752 active site 272623003753 FMN binding site [chemical binding]; other site 272623003754 substrate binding site [chemical binding]; other site 272623003755 3Fe-4S cluster binding site [ion binding]; other site 272623003756 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272623003757 domain interface; other site 272623003758 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 272623003759 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623003760 active site 272623003761 substrate binding site [chemical binding]; other site 272623003762 trimer interface [polypeptide binding]; other site 272623003763 CoA binding site [chemical binding]; other site 272623003764 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272623003765 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272623003766 homodimer interface [polypeptide binding]; other site 272623003767 substrate-cofactor binding pocket; other site 272623003768 catalytic residue [active] 272623003769 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272623003770 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272623003771 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272623003772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003773 catalytic residue [active] 272623003774 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 272623003775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003776 non-specific DNA binding site [nucleotide binding]; other site 272623003777 salt bridge; other site 272623003778 sequence-specific DNA binding site [nucleotide binding]; other site 272623003779 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623003780 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272623003781 RNA/DNA hybrid binding site [nucleotide binding]; other site 272623003782 active site 272623003783 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272623003784 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272623003785 GTP/Mg2+ binding site [chemical binding]; other site 272623003786 G4 box; other site 272623003787 G5 box; other site 272623003788 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272623003789 G1 box; other site 272623003790 G1 box; other site 272623003791 GTP/Mg2+ binding site [chemical binding]; other site 272623003792 Switch I region; other site 272623003793 G2 box; other site 272623003794 G2 box; other site 272623003795 G3 box; other site 272623003796 G3 box; other site 272623003797 Switch II region; other site 272623003798 Switch II region; other site 272623003799 G5 box; other site 272623003800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623003801 Coenzyme A binding pocket [chemical binding]; other site 272623003802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623003803 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623003804 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272623003805 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272623003806 Predicted membrane protein [Function unknown]; Region: COG3152 272623003807 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272623003808 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623003809 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623003810 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 272623003811 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272623003812 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272623003813 Predicted periplasmic or secreted protein [General function prediction only]; Region: COG3443 272623003814 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623003815 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623003816 Integrase core domain; Region: rve; pfam00665 272623003817 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 272623003818 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272623003819 dimer interface [polypeptide binding]; other site 272623003820 PYR/PP interface [polypeptide binding]; other site 272623003821 TPP binding site [chemical binding]; other site 272623003822 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272623003823 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272623003824 TPP-binding site [chemical binding]; other site 272623003825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623003826 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623003827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623003828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623003829 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272623003830 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272623003831 Uncharacterized protein conserved in Streptococci; Region: SP_1775_like; cl19119 272623003832 oligomer interface [polypeptide binding]; other site 272623003833 putative ligand binding site [chemical binding]; other site 272623003834 short chain dehydrogenase; Validated; Region: PRK06182 272623003835 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623003836 NADP binding site [chemical binding]; other site 272623003837 active site 272623003838 steroid binding site; other site 272623003839 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 272623003840 Helix-turn-helix domain; Region: HTH_18; pfam12833 272623003841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623003842 Uncharacterized conserved protein [Function unknown]; Region: COG4283 272623003843 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272623003844 ArsC family; Region: ArsC; pfam03960 272623003845 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272623003846 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272623003847 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 272623003848 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272623003849 substrate-cofactor binding pocket; other site 272623003850 homodimer interface [polypeptide binding]; other site 272623003851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003852 catalytic residue [active] 272623003853 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272623003854 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272623003855 glutamine binding [chemical binding]; other site 272623003856 catalytic triad [active] 272623003857 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272623003858 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272623003859 metal binding site [ion binding]; metal-binding site 272623003860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623003861 ABC-ATPase subunit interface; other site 272623003862 dimer interface [polypeptide binding]; other site 272623003863 putative PBP binding regions; other site 272623003864 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272623003865 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272623003866 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272623003867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272623003868 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272623003869 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272623003870 Walker A/P-loop; other site 272623003871 ATP binding site [chemical binding]; other site 272623003872 Q-loop/lid; other site 272623003873 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272623003874 ABC transporter signature motif; other site 272623003875 Walker B; other site 272623003876 D-loop; other site 272623003877 H-loop/switch region; other site 272623003878 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272623003879 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272623003880 active site 272623003881 metal binding site [ion binding]; metal-binding site 272623003882 DNA binding site [nucleotide binding] 272623003883 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272623003884 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272623003885 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272623003886 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272623003887 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623003888 putative catalytic residues [active] 272623003889 thiol/disulfide switch; other site 272623003890 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 272623003891 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 272623003892 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 272623003893 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272623003894 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272623003895 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272623003896 Walker A/P-loop; other site 272623003897 ATP binding site [chemical binding]; other site 272623003898 Q-loop/lid; other site 272623003899 ABC transporter signature motif; other site 272623003900 Walker B; other site 272623003901 D-loop; other site 272623003902 H-loop/switch region; other site 272623003903 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272623003904 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272623003905 TM-ABC transporter signature motif; other site 272623003906 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272623003907 TM-ABC transporter signature motif; other site 272623003908 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623003909 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623003910 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003911 NAD binding site [chemical binding]; other site 272623003912 dimer interface [polypeptide binding]; other site 272623003913 substrate binding site [chemical binding]; other site 272623003914 pyruvate kinase; Provisional; Region: PRK05826 272623003915 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272623003916 domain interfaces; other site 272623003917 active site 272623003918 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272623003919 active site 272623003920 ADP/pyrophosphate binding site [chemical binding]; other site 272623003921 dimerization interface [polypeptide binding]; other site 272623003922 allosteric effector site; other site 272623003923 fructose-1,6-bisphosphate binding site; other site 272623003924 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272623003925 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272623003926 active site 272623003927 dimer interface [polypeptide binding]; other site 272623003928 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272623003929 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272623003930 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 272623003931 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272623003932 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272623003933 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272623003934 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 272623003935 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272623003936 active site 272623003937 tetramer interface; other site 272623003938 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 272623003939 trimer interface [polypeptide binding]; other site 272623003940 Predicted membrane protein [Function unknown]; Region: COG4769 272623003941 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623003942 substrate binding pocket [chemical binding]; other site 272623003943 chain length determination region; other site 272623003944 substrate-Mg2+ binding site; other site 272623003945 catalytic residues [active] 272623003946 aspartate-rich region 1; other site 272623003947 active site lid residues [active] 272623003948 aspartate-rich region 2; other site 272623003949 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272623003950 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272623003951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003952 S-adenosylmethionine binding site [chemical binding]; other site 272623003953 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 272623003954 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272623003955 active site 272623003956 dimer interface [polypeptide binding]; other site 272623003957 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272623003958 heterodimer interface [polypeptide binding]; other site 272623003959 active site 272623003960 FMN binding site [chemical binding]; other site 272623003961 homodimer interface [polypeptide binding]; other site 272623003962 substrate binding site [chemical binding]; other site 272623003963 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272623003964 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272623003965 FAD binding pocket [chemical binding]; other site 272623003966 FAD binding motif [chemical binding]; other site 272623003967 phosphate binding motif [ion binding]; other site 272623003968 beta-alpha-beta structure motif; other site 272623003969 NAD binding pocket [chemical binding]; other site 272623003970 Iron coordination center [ion binding]; other site 272623003971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623003972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623003973 putative substrate translocation pore; other site 272623003974 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 272623003975 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 272623003976 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272623003977 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 272623003978 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 272623003979 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 272623003980 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 272623003981 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 272623003982 probable active site [active] 272623003983 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003984 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003985 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003986 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623003987 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003988 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623003989 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623003990 Integrase core domain; Region: rve; pfam00665 272623003991 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623003992 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272623003993 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623003994 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272623003995 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 272623003996 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623003997 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272623003998 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272623003999 IMP binding site; other site 272623004000 dimer interface [polypeptide binding]; other site 272623004001 interdomain contacts; other site 272623004002 partial ornithine binding site; other site 272623004003 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272623004004 catalytic residues [active] 272623004005 dimer interface [polypeptide binding]; other site 272623004006 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272623004007 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272623004008 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623004009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623004010 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623004011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004012 motif II; other site 272623004013 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623004014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 272623004015 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623004016 TraX protein; Region: TraX; cl05434 272623004017 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 272623004018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623004019 Ligand Binding Site [chemical binding]; other site 272623004020 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272623004021 active site 272623004022 Domain of unknown function (DUF303); Region: DUF303; pfam03629 272623004023 Bacteriophage bIL286 272623004024 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 272623004025 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623004026 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272623004027 Phage lysis protein, holin; Region: Phage_holin; cl04675 272623004028 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272623004029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623004030 Haemolysin XhlA; Region: XhlA; pfam10779 272623004031 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506 272623004032 Phage tail protein; Region: Sipho_tail; pfam05709 272623004033 Phage tail protein; Region: Sipho_tail; cl17486 272623004034 Phage-related tail protein [Function unknown]; Region: COG5283 272623004035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272623004036 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272623004037 TolA protein; Region: tolA_full; TIGR02794 272623004038 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272623004039 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272623004040 catalytic residue [active] 272623004041 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 272623004042 Phage major tail protein; Region: Phage_tail; pfam04630 272623004043 Protein of unknown function (DUF806); Region: DUF806; pfam05657 272623004044 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 272623004045 phage head-tail adaptor, putative, SPP1 family; Region: gp16_SPP1; TIGR01563 272623004046 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272623004047 oligomerization interface [polypeptide binding]; other site 272623004048 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272623004049 Phage capsid family; Region: Phage_capsid; pfam05065 272623004050 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 272623004051 oligomer interface [polypeptide binding]; other site 272623004052 active site residues [active] 272623004053 Phage-related protein [Function unknown]; Region: COG4695 272623004054 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 272623004055 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623004056 Phage Terminase; Region: Terminase_1; pfam03354 272623004057 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 272623004058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272623004059 active site 272623004060 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623004061 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623004062 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 272623004063 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623004064 trimer interface [polypeptide binding]; other site 272623004065 active site 272623004066 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623004067 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272623004068 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623004069 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272623004070 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272623004071 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 272623004072 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272623004073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623004074 Walker A motif; other site 272623004075 ATP binding site [chemical binding]; other site 272623004076 Walker B motif; other site 272623004077 Putative replisome organizer protein C-terminus; Region: Rep_Org_C; pfam06926 272623004078 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272623004079 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623004080 dimer interface [polypeptide binding]; other site 272623004081 ssDNA binding site [nucleotide binding]; other site 272623004082 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623004083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712 272623004084 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 272623004085 Phage anti-repressor protein [Transcription]; Region: COG3561 272623004086 ORF6C domain; Region: ORF6C; pfam10552 272623004087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004088 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623004089 non-specific DNA binding site [nucleotide binding]; other site 272623004090 salt bridge; other site 272623004091 sequence-specific DNA binding site [nucleotide binding]; other site 272623004092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004093 non-specific DNA binding site [nucleotide binding]; other site 272623004094 salt bridge; other site 272623004095 sequence-specific DNA binding site [nucleotide binding]; other site 272623004096 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272623004097 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 272623004098 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272623004099 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272623004100 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623004101 Int/Topo IB signature motif; other site 272623004102 putative DNA-binding protein; Validated; Region: PRK00118 272623004103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004105 active site 272623004106 phosphorylation site [posttranslational modification] 272623004107 intermolecular recognition site; other site 272623004108 dimerization interface [polypeptide binding]; other site 272623004109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004110 DNA binding site [nucleotide binding] 272623004111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272623004112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623004113 dimer interface [polypeptide binding]; other site 272623004114 phosphorylation site [posttranslational modification] 272623004115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004116 ATP binding site [chemical binding]; other site 272623004117 Mg2+ binding site [ion binding]; other site 272623004118 G-X-G motif; other site 272623004119 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 272623004120 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272623004121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004122 DNA-binding site [nucleotide binding]; DNA binding site 272623004123 UTRA domain; Region: UTRA; pfam07702 272623004124 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272623004125 ligand binding site [chemical binding]; other site 272623004126 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272623004127 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272623004128 active site 272623004129 catalytic motif [active] 272623004130 Zn binding site [ion binding]; other site 272623004131 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272623004132 intersubunit interface [polypeptide binding]; other site 272623004133 active site 272623004134 catalytic residue [active] 272623004135 Autophagy-related protein 27; Region: ATG27; pfam09451 272623004136 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272623004137 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272623004138 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272623004139 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272623004140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272623004141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623004142 S-adenosylmethionine binding site [chemical binding]; other site 272623004143 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272623004144 ATP-binding site [chemical binding]; other site 272623004145 CoA-binding site [chemical binding]; other site 272623004146 Mg2+-binding site [ion binding]; other site 272623004147 Predicted membrane protein [Function unknown]; Region: COG3223 272623004148 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272623004149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004150 non-specific DNA binding site [nucleotide binding]; other site 272623004151 salt bridge; other site 272623004152 sequence-specific DNA binding site [nucleotide binding]; other site 272623004153 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272623004154 ParB-like nuclease domain; Region: ParBc; pfam02195 272623004155 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272623004156 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 272623004157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004158 dimer interface [polypeptide binding]; other site 272623004159 conserved gate region; other site 272623004160 putative PBP binding loops; other site 272623004161 ABC-ATPase subunit interface; other site 272623004162 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272623004163 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272623004164 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 272623004165 Walker A/P-loop; other site 272623004166 ATP binding site [chemical binding]; other site 272623004167 Q-loop/lid; other site 272623004168 ABC transporter signature motif; other site 272623004169 Walker B; other site 272623004170 D-loop; other site 272623004171 H-loop/switch region; other site 272623004172 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272623004173 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272623004174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004175 DNA-binding site [nucleotide binding]; DNA binding site 272623004176 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 272623004177 TrkA-C domain; Region: TrkA_C; pfam02080 272623004178 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 272623004179 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 272623004180 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 272623004181 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 272623004182 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 272623004183 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 272623004184 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272623004185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623004186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623004187 active site 272623004188 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272623004189 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272623004190 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272623004191 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623004192 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272623004193 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623004194 active site turn [active] 272623004195 phosphorylation site [posttranslational modification] 272623004196 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272623004197 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272623004198 HPr interaction site; other site 272623004199 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623004200 active site 272623004201 phosphorylation site [posttranslational modification] 272623004202 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272623004203 CAT RNA binding domain; Region: CAT_RBD; smart01061 272623004204 PRD domain; Region: PRD; pfam00874 272623004205 PRD domain; Region: PRD; pfam00874 272623004206 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272623004207 substrate binding site [chemical binding]; other site 272623004208 active site 272623004209 catalytic residues [active] 272623004210 heterodimer interface [polypeptide binding]; other site 272623004211 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272623004212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623004213 catalytic residue [active] 272623004214 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272623004215 active site 272623004216 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272623004217 active site 272623004218 ribulose/triose binding site [chemical binding]; other site 272623004219 phosphate binding site [ion binding]; other site 272623004220 substrate (anthranilate) binding pocket [chemical binding]; other site 272623004221 product (indole) binding pocket [chemical binding]; other site 272623004222 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272623004223 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272623004224 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272623004225 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272623004226 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272623004227 glutamine binding [chemical binding]; other site 272623004228 catalytic triad [active] 272623004229 anthranilate synthase component I; Provisional; Region: PRK13570 272623004230 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272623004231 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272623004232 Predicted membrane protein [Function unknown]; Region: COG3759 272623004233 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623004234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004235 putative DNA binding site [nucleotide binding]; other site 272623004236 putative Zn2+ binding site [ion binding]; other site 272623004237 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272623004238 dimer interface [polypeptide binding]; other site 272623004239 FMN binding site [chemical binding]; other site 272623004240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623004241 S-adenosylmethionine binding site [chemical binding]; other site 272623004242 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272623004243 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272623004244 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272623004245 metal binding site 2 [ion binding]; metal-binding site 272623004246 putative DNA binding helix; other site 272623004247 metal binding site 1 [ion binding]; metal-binding site 272623004248 dimer interface [polypeptide binding]; other site 272623004249 structural Zn2+ binding site [ion binding]; other site 272623004250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 272623004251 EamA-like transporter family; Region: EamA; pfam00892 272623004252 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272623004253 EamA-like transporter family; Region: EamA; pfam00892 272623004254 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623004255 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623004256 DNA binding residues [nucleotide binding] 272623004257 putative dimer interface [polypeptide binding]; other site 272623004258 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272623004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004260 NAD(P) binding site [chemical binding]; other site 272623004261 active site 272623004262 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272623004263 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272623004264 TPP-binding site; other site 272623004265 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004266 PYR/PP interface [polypeptide binding]; other site 272623004267 dimer interface [polypeptide binding]; other site 272623004268 TPP binding site [chemical binding]; other site 272623004269 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623004271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623004272 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272623004273 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272623004274 Cl binding site [ion binding]; other site 272623004275 oligomer interface [polypeptide binding]; other site 272623004276 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272623004277 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272623004278 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004279 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 272623004280 GMP synthase; Reviewed; Region: guaA; PRK00074 272623004281 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272623004282 AMP/PPi binding site [chemical binding]; other site 272623004283 candidate oxyanion hole; other site 272623004284 catalytic triad [active] 272623004285 potential glutamine specificity residues [chemical binding]; other site 272623004286 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272623004287 ATP Binding subdomain [chemical binding]; other site 272623004288 Ligand Binding sites [chemical binding]; other site 272623004289 Dimerization subdomain; other site 272623004290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272623004291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272623004292 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272623004293 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272623004294 nucleotide binding site [chemical binding]; other site 272623004295 butyrate kinase; Provisional; Region: PRK03011 272623004296 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623004297 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272623004298 Predicted integral membrane protein [Function unknown]; Region: COG5578 272623004299 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004300 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004301 Ca binding site [ion binding]; other site 272623004302 active site 272623004303 catalytic site [active] 272623004304 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 272623004305 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 272623004306 active site 272623004307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272623004308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272623004309 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 272623004310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272623004311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004312 dimer interface [polypeptide binding]; other site 272623004313 conserved gate region; other site 272623004314 putative PBP binding loops; other site 272623004315 ABC-ATPase subunit interface; other site 272623004316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004317 dimer interface [polypeptide binding]; other site 272623004318 conserved gate region; other site 272623004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272623004320 ABC-ATPase subunit interface; other site 272623004321 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272623004322 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 272623004323 active site 272623004324 metal binding site [ion binding]; metal-binding site 272623004325 homodimer interface [polypeptide binding]; other site 272623004326 catalytic site [active] 272623004327 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272623004328 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 272623004329 Uncharacterized conserved protein [Function unknown]; Region: COG3538 272623004330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004331 DNA-binding site [nucleotide binding]; DNA binding site 272623004332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004333 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623004334 ligand binding site [chemical binding]; other site 272623004335 dimerization interface [polypeptide binding]; other site 272623004336 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 272623004337 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 272623004338 putative phosphoketolase; Provisional; Region: PRK05261 272623004339 XFP N-terminal domain; Region: XFP_N; pfam09364 272623004340 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 272623004341 XFP C-terminal domain; Region: XFP_C; pfam09363 272623004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004343 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272623004344 putative substrate translocation pore; other site 272623004345 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272623004346 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623004347 active site 272623004348 substrate binding site [chemical binding]; other site 272623004349 trimer interface [polypeptide binding]; other site 272623004350 CoA binding site [chemical binding]; other site 272623004351 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272623004352 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272623004353 inhibitor binding site; inhibition site 272623004354 active site 272623004355 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004356 putative symporter YagG; Provisional; Region: PRK09669; cl15392 272623004357 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272623004358 active site 272623004359 catalytic residues [active] 272623004360 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272623004361 N- and C-terminal domain interface [polypeptide binding]; other site 272623004362 D-xylulose kinase; Region: XylB; TIGR01312 272623004363 active site 272623004364 MgATP binding site [chemical binding]; other site 272623004365 catalytic site [active] 272623004366 metal binding site [ion binding]; metal-binding site 272623004367 xylulose binding site [chemical binding]; other site 272623004368 homodimer interface [polypeptide binding]; other site 272623004369 xylose isomerase; Provisional; Region: PRK05474 272623004370 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272623004371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623004372 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272623004373 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 272623004374 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272623004375 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272623004376 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272623004377 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272623004378 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272623004379 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272623004380 tetracycline repressor protein TetR; Provisional; Region: PRK13756 272623004381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623004382 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 272623004383 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623004384 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623004385 Integrase core domain; Region: rve; pfam00665 272623004386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623004388 putative substrate translocation pore; other site 272623004389 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 272623004390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004391 motif II; other site 272623004392 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272623004393 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272623004394 purine monophosphate binding site [chemical binding]; other site 272623004395 dimer interface [polypeptide binding]; other site 272623004396 putative catalytic residues [active] 272623004397 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272623004398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004399 active site 272623004400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272623004401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004402 NAD(P) binding site [chemical binding]; other site 272623004403 active site 272623004404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623004405 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272623004406 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623004407 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272623004408 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272623004409 Walker A/P-loop; other site 272623004410 ATP binding site [chemical binding]; other site 272623004411 Q-loop/lid; other site 272623004412 ABC transporter signature motif; other site 272623004413 Walker B; other site 272623004414 D-loop; other site 272623004415 H-loop/switch region; other site 272623004416 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272623004417 active site 272623004418 substrate binding site [chemical binding]; other site 272623004419 cosubstrate binding site; other site 272623004420 catalytic site [active] 272623004421 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272623004422 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272623004423 dimerization interface [polypeptide binding]; other site 272623004424 putative ATP binding site [chemical binding]; other site 272623004425 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272623004426 Clp amino terminal domain; Region: Clp_N; pfam02861 272623004427 Clp amino terminal domain; Region: Clp_N; pfam02861 272623004428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623004429 Walker A motif; other site 272623004430 ATP binding site [chemical binding]; other site 272623004431 Walker B motif; other site 272623004432 arginine finger; other site 272623004433 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 272623004434 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 272623004435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623004436 Walker A motif; other site 272623004437 ATP binding site [chemical binding]; other site 272623004438 Walker B motif; other site 272623004439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272623004440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004441 NAD(P) binding site [chemical binding]; other site 272623004442 active site 272623004443 amidophosphoribosyltransferase; Provisional; Region: PRK07272 272623004444 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272623004445 active site 272623004446 tetramer interface [polypeptide binding]; other site 272623004447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004448 active site 272623004449 short chain dehydrogenase; Provisional; Region: PRK06180 272623004450 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623004451 NADP binding site [chemical binding]; other site 272623004452 active site 272623004453 steroid binding site; other site 272623004454 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272623004455 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272623004456 dimerization interface [polypeptide binding]; other site 272623004457 ATP binding site [chemical binding]; other site 272623004458 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272623004459 dimerization interface [polypeptide binding]; other site 272623004460 ATP binding site [chemical binding]; other site 272623004461 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272623004462 putative active site [active] 272623004463 catalytic triad [active] 272623004464 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 272623004465 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272623004466 ATP binding site [chemical binding]; other site 272623004467 active site 272623004468 substrate binding site [chemical binding]; other site 272623004469 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272623004470 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272623004471 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272623004472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4334 272623004473 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272623004474 classical (c) SDRs; Region: SDR_c; cd05233 272623004475 NAD(P) binding site [chemical binding]; other site 272623004476 active site 272623004477 putative transporter; Provisional; Region: PRK10504 272623004478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004479 putative substrate translocation pore; other site 272623004480 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623004481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272623004482 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272623004483 dimerization interface [polypeptide binding]; other site 272623004484 active site 272623004485 putative transposase OrfB; Reviewed; Region: PHA02517 272623004486 HTH-like domain; Region: HTH_21; pfam13276 272623004487 Integrase core domain; Region: rve; pfam00665 272623004488 Integrase core domain; Region: rve_3; pfam13683 272623004489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623004490 Transposase; Region: HTH_Tnp_1; pfam01527 272623004491 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 272623004492 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272623004493 catalytic Zn binding site [ion binding]; other site 272623004494 NAD(P) binding site [chemical binding]; other site 272623004495 structural Zn binding site [ion binding]; other site 272623004496 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004497 Predicted membrane protein [Function unknown]; Region: COG4905 272623004498 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 272623004499 active site 272623004500 FMN binding site [chemical binding]; other site 272623004501 substrate binding site [chemical binding]; other site 272623004502 catalytic residues [active] 272623004503 homodimer interface [polypeptide binding]; other site 272623004504 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 272623004505 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272623004506 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272623004507 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272623004508 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623004509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623004510 ABC transporter; Region: ABC_tran_2; pfam12848 272623004511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272623004512 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272623004513 putative active site [active] 272623004514 metal binding site [ion binding]; metal-binding site 272623004515 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 272623004516 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272623004517 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272623004518 active site 272623004519 NTP binding site [chemical binding]; other site 272623004520 metal binding triad [ion binding]; metal-binding site 272623004521 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272623004522 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272623004523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272623004524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623004525 Coenzyme A binding pocket [chemical binding]; other site 272623004526 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272623004527 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272623004528 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272623004529 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272623004530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 272623004531 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272623004532 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272623004533 RimM N-terminal domain; Region: RimM; pfam01782 272623004534 PRC-barrel domain; Region: PRC; pfam05239 272623004535 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272623004536 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623004537 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623004538 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 272623004539 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272623004540 C-terminal domain interface [polypeptide binding]; other site 272623004541 active site 272623004542 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272623004543 active site 272623004544 N-terminal domain interface [polypeptide binding]; other site 272623004545 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272623004546 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272623004547 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272623004548 homodimer interface [polypeptide binding]; other site 272623004549 catalytic residues [active] 272623004550 NAD binding site [chemical binding]; other site 272623004551 substrate binding pocket [chemical binding]; other site 272623004552 flexible flap; other site 272623004553 putative acyltransferase; Provisional; Region: PRK05790 272623004554 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272623004555 dimer interface [polypeptide binding]; other site 272623004556 active site 272623004557 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272623004558 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 272623004559 dimer interface [polypeptide binding]; other site 272623004560 active site 272623004561 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272623004562 active site 272623004563 trimer interface [polypeptide binding]; other site 272623004564 allosteric site; other site 272623004565 active site lid [active] 272623004566 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272623004567 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272623004568 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623004569 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272623004570 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272623004571 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623004572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004573 non-specific DNA binding site [nucleotide binding]; other site 272623004574 salt bridge; other site 272623004575 sequence-specific DNA binding site [nucleotide binding]; other site 272623004576 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 272623004577 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004578 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004579 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004580 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004581 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272623004582 GTP1/OBG; Region: GTP1_OBG; pfam01018 272623004583 Obg GTPase; Region: Obg; cd01898 272623004584 G1 box; other site 272623004585 GTP/Mg2+ binding site [chemical binding]; other site 272623004586 Switch I region; other site 272623004587 G2 box; other site 272623004588 G3 box; other site 272623004589 Switch II region; other site 272623004590 G4 box; other site 272623004591 G5 box; other site 272623004592 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272623004593 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272623004594 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272623004595 Cell division protein FtsQ; Region: FtsQ; pfam03799 272623004596 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272623004597 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272623004598 homodimer interface [polypeptide binding]; other site 272623004599 active site 272623004600 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272623004601 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 272623004602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623004603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623004604 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272623004605 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272623004606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623004607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272623004608 dimerization interface [polypeptide binding]; other site 272623004609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623004610 dimer interface [polypeptide binding]; other site 272623004611 phosphorylation site [posttranslational modification] 272623004612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004613 ATP binding site [chemical binding]; other site 272623004614 Mg2+ binding site [ion binding]; other site 272623004615 G-X-G motif; other site 272623004616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004618 active site 272623004619 phosphorylation site [posttranslational modification] 272623004620 intermolecular recognition site; other site 272623004621 dimerization interface [polypeptide binding]; other site 272623004622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004623 DNA binding site [nucleotide binding] 272623004624 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272623004625 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272623004626 conserved hypothetical protein; Region: TIGR02328 272623004627 Surface antigen [General function prediction only]; Region: COG3942 272623004628 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 272623004629 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272623004630 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272623004631 putative active site [active] 272623004632 putative metal binding site [ion binding]; other site 272623004633 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272623004634 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272623004635 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272623004636 catalytic site [active] 272623004637 subunit interface [polypeptide binding]; other site 272623004638 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272623004639 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623004640 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272623004641 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 272623004642 Sulfate transporter family; Region: Sulfate_transp; cl19250 272623004643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004644 active site 272623004645 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 272623004646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004647 dimerization interface [polypeptide binding]; other site 272623004648 putative DNA binding site [nucleotide binding]; other site 272623004649 putative Zn2+ binding site [ion binding]; other site 272623004650 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272623004651 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272623004652 putative catalytic cysteine [active] 272623004653 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 272623004654 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272623004655 nucleotide binding site [chemical binding]; other site 272623004656 homotetrameric interface [polypeptide binding]; other site 272623004657 putative phosphate binding site [ion binding]; other site 272623004658 putative allosteric binding site; other site 272623004659 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272623004660 Family of unknown function (DUF438); Region: DUF438; pfam04282 272623004661 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272623004662 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 272623004663 Predicted membrane protein [Function unknown]; Region: COG4392 272623004664 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 272623004665 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272623004666 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272623004667 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623004668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623004669 Coenzyme A binding pocket [chemical binding]; other site 272623004670 signal recognition particle protein; Provisional; Region: PRK10867 272623004671 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272623004672 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272623004673 P loop; other site 272623004674 GTP binding site [chemical binding]; other site 272623004675 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272623004676 Forkhead N-terminal region; Region: Fork_head_N; pfam08430 272623004677 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272623004678 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272623004679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272623004680 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272623004681 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272623004682 MgtC family; Region: MgtC; pfam02308 272623004683 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272623004684 dimer interface [polypeptide binding]; other site 272623004685 active site 272623004686 catalytic residue [active] 272623004687 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272623004688 nudix motif; other site 272623004689 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272623004690 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272623004691 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272623004692 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623004693 amphipathic channel; other site 272623004694 Asn-Pro-Ala signature motifs; other site 272623004695 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272623004696 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272623004697 TPP-binding site [chemical binding]; other site 272623004698 dimer interface [polypeptide binding]; other site 272623004699 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004700 PYR/PP interface [polypeptide binding]; other site 272623004701 dimer interface [polypeptide binding]; other site 272623004702 TPP binding site [chemical binding]; other site 272623004703 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004704 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272623004705 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272623004706 active site 272623004707 intersubunit interface [polypeptide binding]; other site 272623004708 catalytic residue [active] 272623004709 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272623004710 substrate binding site [chemical binding]; other site 272623004711 ATP binding site [chemical binding]; other site 272623004712 glucuronate isomerase; Reviewed; Region: PRK02925 272623004713 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272623004714 active site 272623004715 catalytic residues [active] 272623004716 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004718 putative substrate translocation pore; other site 272623004719 mannonate dehydratase; Provisional; Region: PRK03906 272623004720 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 272623004721 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272623004722 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272623004723 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272623004724 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272623004725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004726 DNA-binding site [nucleotide binding]; DNA binding site 272623004727 FCD domain; Region: FCD; pfam07729 272623004728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623004730 putative substrate translocation pore; other site 272623004731 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272623004732 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272623004733 ligand binding site [chemical binding]; other site 272623004734 dimerization interface [polypeptide binding]; other site 272623004735 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272623004736 TM-ABC transporter signature motif; other site 272623004737 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272623004738 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272623004739 Walker A/P-loop; other site 272623004740 ATP binding site [chemical binding]; other site 272623004741 Q-loop/lid; other site 272623004742 ABC transporter signature motif; other site 272623004743 Walker B; other site 272623004744 D-loop; other site 272623004745 H-loop/switch region; other site 272623004746 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272623004747 D-ribose pyranase; Provisional; Region: PRK11797 272623004748 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272623004749 substrate binding site [chemical binding]; other site 272623004750 dimer interface [polypeptide binding]; other site 272623004751 ATP binding site [chemical binding]; other site 272623004752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004754 DNA binding site [nucleotide binding] 272623004755 domain linker motif; other site 272623004756 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623004757 dimerization interface [polypeptide binding]; other site 272623004758 ligand binding site [chemical binding]; other site 272623004759 adenylosuccinate lyase; Provisional; Region: PRK07492 272623004760 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272623004761 tetramer interface [polypeptide binding]; other site 272623004762 active site 272623004763 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272623004764 active site 272623004765 catalytic residue [active] 272623004766 dimer interface [polypeptide binding]; other site 272623004767 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 272623004768 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272623004769 catalytic residues [active] 272623004770 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 272623004771 MutS domain III; Region: MutS_III; pfam05192 272623004772 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 272623004773 Walker A/P-loop; other site 272623004774 ATP binding site [chemical binding]; other site 272623004775 Q-loop/lid; other site 272623004776 ABC transporter signature motif; other site 272623004777 Walker B; other site 272623004778 D-loop; other site 272623004779 H-loop/switch region; other site 272623004780 Smr domain; Region: Smr; pfam01713 272623004781 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272623004782 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272623004783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623004784 catabolite control protein A; Region: ccpA; TIGR01481 272623004785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004786 DNA binding site [nucleotide binding] 272623004787 domain linker motif; other site 272623004788 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272623004789 dimerization interface [polypeptide binding]; other site 272623004790 effector binding site; other site 272623004791 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272623004792 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272623004793 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272623004794 active site 272623004795 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 272623004796 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272623004797 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272623004798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272623004799 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272623004800 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 272623004801 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272623004802 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272623004803 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272623004804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272623004806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272623004807 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272623004808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004809 motif II; other site 272623004810 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623004811 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272623004812 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272623004813 ATP-binding site [chemical binding]; other site 272623004814 Sugar specificity; other site 272623004815 Pyrimidine base specificity; other site 272623004816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272623004817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272623004818 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 272623004819 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 272623004820 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 272623004821 putative active site [active] 272623004822 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272623004823 Cl- selectivity filter; other site 272623004824 Cl- binding residues [ion binding]; other site 272623004825 pore gating glutamate residue; other site 272623004826 dimer interface [polypeptide binding]; other site 272623004827 H+/Cl- coupling transport residue; other site 272623004828 TrkA-C domain; Region: TrkA_C; pfam02080 272623004829 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004830 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623004831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004832 non-specific DNA binding site [nucleotide binding]; other site 272623004833 salt bridge; other site 272623004834 sequence-specific DNA binding site [nucleotide binding]; other site 272623004835 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623004836 Predicted membrane protein [Function unknown]; Region: COG1511 272623004837 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272623004838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272623004839 dimer interface [polypeptide binding]; other site 272623004840 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272623004841 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 272623004842 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272623004843 Uncharacterized conserved protein [Function unknown]; Region: COG0759 272623004844 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272623004845 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272623004846 TPP-binding site; other site 272623004847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004848 PYR/PP interface [polypeptide binding]; other site 272623004849 dimer interface [polypeptide binding]; other site 272623004850 TPP binding site [chemical binding]; other site 272623004851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623004853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623004854 dimer interface [polypeptide binding]; other site 272623004855 phosphorylation site [posttranslational modification] 272623004856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004857 ATP binding site [chemical binding]; other site 272623004858 Mg2+ binding site [ion binding]; other site 272623004859 G-X-G motif; other site 272623004860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004862 active site 272623004863 phosphorylation site [posttranslational modification] 272623004864 intermolecular recognition site; other site 272623004865 dimerization interface [polypeptide binding]; other site 272623004866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004867 DNA binding site [nucleotide binding] 272623004868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004870 DNA binding site [nucleotide binding] 272623004871 domain linker motif; other site 272623004872 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272623004873 putative dimerization interface [polypeptide binding]; other site 272623004874 putative ligand binding site [chemical binding]; other site 272623004875 maltose phosphorylase; Provisional; Region: PRK13807 272623004876 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272623004877 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272623004878 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272623004879 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004880 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004881 Ca binding site [ion binding]; other site 272623004882 active site 272623004883 catalytic site [active] 272623004884 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272623004885 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 272623004886 Ca binding site [ion binding]; other site 272623004887 active site 272623004888 catalytic site [active] 272623004889 maltose O-acetyltransferase; Provisional; Region: PRK10092 272623004890 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623004891 active site 272623004892 substrate binding site [chemical binding]; other site 272623004893 trimer interface [polypeptide binding]; other site 272623004894 CoA binding site [chemical binding]; other site 272623004895 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004896 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004897 Ca binding site [ion binding]; other site 272623004898 active site 272623004899 catalytic site [active] 272623004900 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272623004901 homodimer interface [polypeptide binding]; other site 272623004902 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272623004903 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272623004904 active site 272623004905 homodimer interface [polypeptide binding]; other site 272623004906 catalytic site [active] 272623004907 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272623004908 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272623004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004910 dimer interface [polypeptide binding]; other site 272623004911 conserved gate region; other site 272623004912 putative PBP binding loops; other site 272623004913 ABC-ATPase subunit interface; other site 272623004914 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272623004915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004916 dimer interface [polypeptide binding]; other site 272623004917 conserved gate region; other site 272623004918 putative PBP binding loops; other site 272623004919 ABC-ATPase subunit interface; other site 272623004920 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 272623004921 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004922 LssY C-terminus; Region: LssY_C; pfam14067 272623004923 putative transposase OrfB; Reviewed; Region: PHA02517 272623004924 HTH-like domain; Region: HTH_21; pfam13276 272623004925 Integrase core domain; Region: rve; pfam00665 272623004926 Integrase core domain; Region: rve_3; pfam13683 272623004927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623004928 Transposase; Region: HTH_Tnp_1; pfam01527 272623004929 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623004930 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623004931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004932 dimerization interface [polypeptide binding]; other site 272623004933 putative DNA binding site [nucleotide binding]; other site 272623004934 putative Zn2+ binding site [ion binding]; other site 272623004935 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 272623004936 putative active site [active] 272623004937 putative FMN binding site [chemical binding]; other site 272623004938 putative substrate binding site [chemical binding]; other site 272623004939 putative catalytic residue [active] 272623004940 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623004941 putative substrate binding site [chemical binding]; other site 272623004942 nucleotide binding site [chemical binding]; other site 272623004943 nucleotide binding site [chemical binding]; other site 272623004944 homodimer interface [polypeptide binding]; other site 272623004945 agmatine deiminase; Provisional; Region: PRK13551 272623004946 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623004947 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623004948 Integrase core domain; Region: rve; pfam00665 272623004949 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623004950 putrescine carbamoyltransferase; Provisional; Region: PRK02255 272623004951 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623004952 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272623004953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272623004954 DNA binding residues [nucleotide binding] 272623004955 dimerization interface [polypeptide binding]; other site 272623004956 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272623004957 cytidylate kinase; Provisional; Region: cmk; PRK00023 272623004958 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272623004959 CMP-binding site; other site 272623004960 The sites determining sugar specificity; other site 272623004961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272623004962 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 272623004963 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272623004964 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272623004965 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272623004966 active pocket/dimerization site; other site 272623004967 active site 272623004968 phosphorylation site [posttranslational modification] 272623004969 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272623004970 active site 272623004971 phosphorylation site [posttranslational modification] 272623004972 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272623004973 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272623004974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 272623004975 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623004976 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623004977 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623004978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 272623004979 seryl-tRNA synthetase; Provisional; Region: PRK05431 272623004980 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272623004981 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272623004982 dimer interface [polypeptide binding]; other site 272623004983 active site 272623004984 motif 1; other site 272623004985 motif 2; other site 272623004986 motif 3; other site 272623004987 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272623004988 putative dimer interface [polypeptide binding]; other site 272623004989 catalytic triad [active] 272623004990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623004991 catalytic core [active] 272623004992 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272623004993 PhoU domain; Region: PhoU; pfam01895 272623004994 PhoU domain; Region: PhoU; pfam01895 272623004995 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 272623004996 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272623004997 Walker A/P-loop; other site 272623004998 ATP binding site [chemical binding]; other site 272623004999 Q-loop/lid; other site 272623005000 ABC transporter signature motif; other site 272623005001 Walker B; other site 272623005002 D-loop; other site 272623005003 H-loop/switch region; other site 272623005004 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 272623005005 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272623005006 Walker A/P-loop; other site 272623005007 ATP binding site [chemical binding]; other site 272623005008 Q-loop/lid; other site 272623005009 ABC transporter signature motif; other site 272623005010 Walker B; other site 272623005011 D-loop; other site 272623005012 H-loop/switch region; other site 272623005013 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272623005014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005015 dimer interface [polypeptide binding]; other site 272623005016 conserved gate region; other site 272623005017 putative PBP binding loops; other site 272623005018 ABC-ATPase subunit interface; other site 272623005019 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272623005020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005021 dimer interface [polypeptide binding]; other site 272623005022 conserved gate region; other site 272623005023 putative PBP binding loops; other site 272623005024 ABC-ATPase subunit interface; other site 272623005025 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272623005026 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272623005027 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272623005028 SmpB-tmRNA interface; other site 272623005029 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 272623005030 catalytic triad [active] 272623005031 oxyanion hole [active] 272623005032 active site 272623005033 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272623005034 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272623005035 motif 1; other site 272623005036 active site 272623005037 motif 2; other site 272623005038 motif 3; other site 272623005039 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272623005040 DHHA1 domain; Region: DHHA1; pfam02272 272623005041 foldase protein PrsA; Reviewed; Region: PRK12450 272623005042 SurA N-terminal domain; Region: SurA_N_3; cl07813 272623005043 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272623005044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623005045 S-adenosylmethionine binding site [chemical binding]; other site 272623005046 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272623005047 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272623005048 active site 272623005049 Zn binding site [ion binding]; other site 272623005050 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 272623005051 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623005052 putative active site [active] 272623005053 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 272623005054 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272623005055 Sulfate transporter family; Region: Sulfate_transp; cl19250 272623005056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623005057 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623005058 active site 272623005059 motif I; other site 272623005060 motif II; other site 272623005061 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623005062 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 272623005063 Cysteine-rich domain; Region: CCG; pfam02754 272623005064 Cysteine-rich domain; Region: CCG; pfam02754 272623005065 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 272623005066 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272623005067 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272623005068 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 272623005069 Uncharacterized conserved protein [Function unknown]; Region: COG1556 272623005070 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272623005071 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272623005072 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272623005073 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272623005074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623005075 Zn2+ binding site [ion binding]; other site 272623005076 Mg2+ binding site [ion binding]; other site 272623005077 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272623005078 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272623005079 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272623005080 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272623005081 AAA domain; Region: AAA_30; pfam13604 272623005082 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272623005083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623005084 catalytic core [active] 272623005085 prephenate dehydratase; Provisional; Region: PRK11898 272623005086 Prephenate dehydratase; Region: PDT; pfam00800 272623005087 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272623005088 putative L-Phe binding site [chemical binding]; other site 272623005089 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272623005090 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272623005091 ADP binding site [chemical binding]; other site 272623005092 magnesium binding site [ion binding]; other site 272623005093 putative shikimate binding site; other site 272623005094 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272623005095 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272623005096 hinge; other site 272623005097 active site 272623005098 prephenate dehydrogenase; Validated; Region: PRK06545 272623005099 prephenate dehydrogenase; Validated; Region: PRK08507 272623005100 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 272623005101 rod shape-determining protein MreC; Region: MreC; cl19252 272623005102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623005103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623005104 ATP binding site [chemical binding]; other site 272623005105 Mg2+ binding site [ion binding]; other site 272623005106 G-X-G motif; other site 272623005107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623005108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623005109 active site 272623005110 phosphorylation site [posttranslational modification] 272623005111 intermolecular recognition site; other site 272623005112 dimerization interface [polypeptide binding]; other site 272623005113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623005114 DNA binding site [nucleotide binding] 272623005115 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272623005116 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272623005117 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272623005118 FtsX-like permease family; Region: FtsX; pfam02687 272623005119 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623005120 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272623005121 Walker A/P-loop; other site 272623005122 ATP binding site [chemical binding]; other site 272623005123 Q-loop/lid; other site 272623005124 ABC transporter signature motif; other site 272623005125 Walker B; other site 272623005126 D-loop; other site 272623005127 H-loop/switch region; other site 272623005128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 272623005129 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272623005130 Tetramer interface [polypeptide binding]; other site 272623005131 active site 272623005132 FMN-binding site [chemical binding]; other site 272623005133 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272623005134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623005135 active site 272623005136 motif I; other site 272623005137 motif II; other site 272623005138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 272623005139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272623005140 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272623005141 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272623005142 active site 272623005143 dimer interface [polypeptide binding]; other site 272623005144 metal binding site [ion binding]; metal-binding site 272623005145 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272623005146 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272623005147 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272623005148 shikimate binding site; other site 272623005149 NAD(P) binding site [chemical binding]; other site 272623005150 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272623005151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623005152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623005153 substrate binding pocket [chemical binding]; other site 272623005154 membrane-bound complex binding site; other site 272623005155 hinge residues; other site 272623005156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623005157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623005158 substrate binding pocket [chemical binding]; other site 272623005159 membrane-bound complex binding site; other site 272623005160 hinge residues; other site 272623005161 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272623005162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005163 dimer interface [polypeptide binding]; other site 272623005164 conserved gate region; other site 272623005165 putative PBP binding loops; other site 272623005166 ABC-ATPase subunit interface; other site 272623005167 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623005168 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272623005169 Walker A/P-loop; other site 272623005170 ATP binding site [chemical binding]; other site 272623005171 Q-loop/lid; other site 272623005172 ABC transporter signature motif; other site 272623005173 Walker B; other site 272623005174 D-loop; other site 272623005175 H-loop/switch region; other site 272623005176 legume lectins; Region: lectin_L-type; cl14058 272623005177 homotetramer interaction site [polypeptide binding]; other site 272623005178 carbohydrate binding site [chemical binding]; other site 272623005179 metal binding site [ion binding]; metal-binding site 272623005180 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272623005181 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272623005182 gamma subunit interface [polypeptide binding]; other site 272623005183 epsilon subunit interface [polypeptide binding]; other site 272623005184 LBP interface [polypeptide binding]; other site 272623005185 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272623005186 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272623005187 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272623005188 alpha subunit interaction interface [polypeptide binding]; other site 272623005189 Walker A motif; other site 272623005190 ATP binding site [chemical binding]; other site 272623005191 Walker B motif; other site 272623005192 inhibitor binding site; inhibition site 272623005193 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272623005194 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272623005195 core domain interface [polypeptide binding]; other site 272623005196 delta subunit interface [polypeptide binding]; other site 272623005197 epsilon subunit interface [polypeptide binding]; other site 272623005198 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272623005199 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272623005200 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272623005201 beta subunit interaction interface [polypeptide binding]; other site 272623005202 Walker A motif; other site 272623005203 ATP binding site [chemical binding]; other site 272623005204 Walker B motif; other site 272623005205 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272623005206 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272623005207 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272623005208 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272623005209 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272623005210 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 272623005211 Predicted esterase [General function prediction only]; Region: COG0627 272623005212 S-formylglutathione hydrolase; Region: PLN02442 272623005213 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272623005214 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272623005215 Competence protein; Region: Competence; pfam03772 272623005216 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272623005217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272623005218 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 272623005219 SLBB domain; Region: SLBB; pfam10531 272623005220 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272623005221 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272623005222 Acyltransferase family; Region: Acyl_transf_3; cl19154 272623005223 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272623005224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623005225 Walker A/P-loop; other site 272623005226 ATP binding site [chemical binding]; other site 272623005227 Q-loop/lid; other site 272623005228 ABC transporter signature motif; other site 272623005229 Walker B; other site 272623005230 D-loop; other site 272623005231 H-loop/switch region; other site 272623005232 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272623005233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272623005234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005235 Coenzyme A binding pocket [chemical binding]; other site 272623005236 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272623005237 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272623005238 transmembrane helices; other site 272623005239 Putative transcription activator [Transcription]; Region: TenA; COG0819 272623005240 CHY zinc finger; Region: zf-CHY; cl19861 272623005241 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272623005242 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 272623005243 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272623005244 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272623005245 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272623005246 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 272623005247 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272623005248 acyl-activating enzyme (AAE) consensus motif; other site 272623005249 AMP binding site [chemical binding]; other site 272623005250 active site 272623005251 CoA binding site [chemical binding]; other site 272623005252 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 272623005253 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272623005254 dimer interface [polypeptide binding]; other site 272623005255 active site 272623005256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272623005257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005258 NAD(P) binding site [chemical binding]; other site 272623005259 active site 272623005260 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272623005261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272623005262 FMN binding site [chemical binding]; other site 272623005263 substrate binding site [chemical binding]; other site 272623005264 putative catalytic residue [active] 272623005265 FeS assembly protein SufB; Region: sufB; TIGR01980 272623005266 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272623005267 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272623005268 trimerization site [polypeptide binding]; other site 272623005269 active site 272623005270 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272623005271 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272623005272 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272623005273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623005274 catalytic residue [active] 272623005275 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272623005276 FeS assembly protein SufD; Region: sufD; TIGR01981 272623005277 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272623005278 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272623005279 Walker A/P-loop; other site 272623005280 ATP binding site [chemical binding]; other site 272623005281 Q-loop/lid; other site 272623005282 ABC transporter signature motif; other site 272623005283 Walker B; other site 272623005284 D-loop; other site 272623005285 H-loop/switch region; other site 272623005286 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272623005287 Mg++ binding site [ion binding]; other site 272623005288 putative catalytic motif [active] 272623005289 substrate binding site [chemical binding]; other site 272623005290 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 272623005291 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623005292 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272623005293 Walker A/P-loop; other site 272623005294 ATP binding site [chemical binding]; other site 272623005295 Q-loop/lid; other site 272623005296 ABC transporter signature motif; other site 272623005297 Walker B; other site 272623005298 D-loop; other site 272623005299 H-loop/switch region; other site 272623005300 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272623005301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005302 dimer interface [polypeptide binding]; other site 272623005303 conserved gate region; other site 272623005304 putative PBP binding loops; other site 272623005305 ABC-ATPase subunit interface; other site 272623005306 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272623005307 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272623005308 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272623005309 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272623005310 beta and beta' interface [polypeptide binding]; other site 272623005311 beta' and sigma factor interface [polypeptide binding]; other site 272623005312 Zn-binding [ion binding]; other site 272623005313 active site region [active] 272623005314 catalytic site [active] 272623005315 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 272623005316 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272623005317 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272623005318 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272623005319 G-loop; other site 272623005320 DNA binding site [nucleotide binding] 272623005321 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272623005322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272623005323 RPB12 interaction site [polypeptide binding]; other site 272623005324 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272623005325 RPB1 interaction site [polypeptide binding]; other site 272623005326 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272623005327 RPB10 interaction site [polypeptide binding]; other site 272623005328 RPB11 interaction site [polypeptide binding]; other site 272623005329 RPB3 interaction site [polypeptide binding]; other site 272623005330 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 272623005331 CodY GAF-like domain; Region: CodY; pfam06018 272623005332 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623005333 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272623005334 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272623005335 active site 272623005336 Zn binding site [ion binding]; other site 272623005337 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272623005338 active site 272623005339 DNA binding site [nucleotide binding] 272623005340 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272623005341 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272623005342 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 272623005343 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623005344 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623005345 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623005346 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 272623005347 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 272623005348 NAD binding site [chemical binding]; other site 272623005349 substrate binding site [chemical binding]; other site 272623005350 catalytic Zn binding site [ion binding]; other site 272623005351 tetramer interface [polypeptide binding]; other site 272623005352 structural Zn binding site [ion binding]; other site 272623005353 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272623005354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623005355 ATP binding site [chemical binding]; other site 272623005356 putative Mg++ binding site [ion binding]; other site 272623005357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623005358 nucleotide binding region [chemical binding]; other site 272623005359 ATP-binding site [chemical binding]; other site 272623005360 RQC domain; Region: RQC; pfam09382 272623005361 HRDC domain; Region: HRDC; pfam00570 272623005362 inner membrane transporter YjeM; Provisional; Region: PRK15238 272623005363 peptidase T-like protein; Region: PepT-like; TIGR01883 272623005364 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272623005365 metal binding site [ion binding]; metal-binding site 272623005366 dimer interface [polypeptide binding]; other site 272623005367 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272623005368 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272623005369 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272623005370 DHH family; Region: DHH; pfam01368 272623005371 DHHA2 domain; Region: DHHA2; pfam02833 272623005372 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 272623005373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623005374 FeS/SAM binding site; other site 272623005375 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272623005376 Domain of unknown function DUF21; Region: DUF21; pfam01595 272623005377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272623005378 Transporter associated domain; Region: CorC_HlyC; pfam03471 272623005379 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272623005380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272623005381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005382 Coenzyme A binding pocket [chemical binding]; other site 272623005383 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272623005384 putative uracil binding site [chemical binding]; other site 272623005385 putative active site [active] 272623005386 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272623005387 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272623005388 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272623005389 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272623005390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623005391 catalytic core [active] 272623005392 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272623005393 GIY-YIG motif/motif A; other site 272623005394 putative active site [active] 272623005395 putative metal binding site [ion binding]; other site 272623005396 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623005397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272623005398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272623005399 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272623005400 Thiamine pyrophosphokinase; Region: TPK; cd07995 272623005401 active site 272623005402 dimerization interface [polypeptide binding]; other site 272623005403 thiamine binding site [chemical binding]; other site 272623005404 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 272623005405 putative metal binding site [ion binding]; other site 272623005406 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272623005407 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272623005408 putative dimer interface [polypeptide binding]; other site 272623005409 putative anticodon binding site; other site 272623005410 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272623005411 homodimer interface [polypeptide binding]; other site 272623005412 motif 1; other site 272623005413 motif 2; other site 272623005414 active site 272623005415 motif 3; other site 272623005416 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 272623005417 GIY-YIG motif/motif A; other site 272623005418 aspartate aminotransferase; Provisional; Region: PRK05764 272623005419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623005420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005421 homodimer interface [polypeptide binding]; other site 272623005422 catalytic residue [active] 272623005423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272623005424 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 272623005425 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623005426 active site 272623005427 catalytic site [active] 272623005428 substrate binding site [chemical binding]; other site 272623005429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272623005430 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272623005431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623005432 Ligand Binding Site [chemical binding]; other site 272623005433 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272623005434 Domain of unknown function DUF21; Region: DUF21; pfam01595 272623005435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272623005436 Transporter associated domain; Region: CorC_HlyC; smart01091 272623005437 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272623005438 active site 272623005439 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272623005440 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 272623005441 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272623005442 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272623005443 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272623005444 peptide binding site [polypeptide binding]; other site 272623005445 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272623005446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272623005447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005448 dimer interface [polypeptide binding]; other site 272623005449 conserved gate region; other site 272623005450 putative PBP binding loops; other site 272623005451 ABC-ATPase subunit interface; other site 272623005452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272623005453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005454 dimer interface [polypeptide binding]; other site 272623005455 conserved gate region; other site 272623005456 putative PBP binding loops; other site 272623005457 ABC-ATPase subunit interface; other site 272623005458 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272623005459 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272623005460 Walker A/P-loop; other site 272623005461 ATP binding site [chemical binding]; other site 272623005462 Q-loop/lid; other site 272623005463 ABC transporter signature motif; other site 272623005464 Walker B; other site 272623005465 D-loop; other site 272623005466 H-loop/switch region; other site 272623005467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272623005468 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272623005469 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272623005470 Walker A/P-loop; other site 272623005471 ATP binding site [chemical binding]; other site 272623005472 Q-loop/lid; other site 272623005473 ABC transporter signature motif; other site 272623005474 Walker B; other site 272623005475 D-loop; other site 272623005476 H-loop/switch region; other site 272623005477 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272623005478 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272623005479 23S rRNA binding site [nucleotide binding]; other site 272623005480 L21 binding site [polypeptide binding]; other site 272623005481 L13 binding site [polypeptide binding]; other site 272623005482 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272623005483 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272623005484 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272623005485 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272623005486 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272623005487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623005488 motif II; other site 272623005489 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272623005490 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272623005491 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272623005492 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 272623005493 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 272623005494 active site 272623005495 metal binding site [ion binding]; metal-binding site 272623005496 dimerization interface [polypeptide binding]; other site 272623005497 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272623005498 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272623005499 active site 272623005500 HIGH motif; other site 272623005501 KMSKS motif; other site 272623005502 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272623005503 tRNA binding surface [nucleotide binding]; other site 272623005504 anticodon binding site; other site 272623005505 Predicted integral membrane protein [Function unknown]; Region: COG3548 272623005506 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272623005507 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272623005508 trimer interface [polypeptide binding]; other site 272623005509 active site 272623005510 substrate binding site [chemical binding]; other site 272623005511 CoA binding site [chemical binding]; other site 272623005512 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 272623005513 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272623005514 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272623005515 RNase E interface [polypeptide binding]; other site 272623005516 trimer interface [polypeptide binding]; other site 272623005517 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272623005518 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272623005519 RNase E interface [polypeptide binding]; other site 272623005520 trimer interface [polypeptide binding]; other site 272623005521 active site 272623005522 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272623005523 putative nucleic acid binding region [nucleotide binding]; other site 272623005524 G-X-X-G motif; other site 272623005525 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623005526 RNA binding site [nucleotide binding]; other site 272623005527 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 272623005528 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272623005529 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623005530 active site 272623005531 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623005532 Ligand Binding Site [chemical binding]; other site 272623005533 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272623005534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623005535 catalytic residue [active] 272623005536 Putative amino acid metabolizm; Region: DUF1831; pfam08866 272623005537 elongation factor Tu; Reviewed; Region: PRK00049 272623005538 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272623005539 G1 box; other site 272623005540 GEF interaction site [polypeptide binding]; other site 272623005541 GTP/Mg2+ binding site [chemical binding]; other site 272623005542 Switch I region; other site 272623005543 G2 box; other site 272623005544 G3 box; other site 272623005545 Switch II region; other site 272623005546 G4 box; other site 272623005547 G5 box; other site 272623005548 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272623005549 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272623005550 Antibiotic Binding Site [chemical binding]; other site 272623005551 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272623005552 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272623005553 active site 272623005554 HIGH motif; other site 272623005555 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272623005556 KMSKS motif; other site 272623005557 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272623005558 tRNA binding surface [nucleotide binding]; other site 272623005559 anticodon binding site; other site 272623005560 DivIVA protein; Region: DivIVA; pfam05103 272623005561 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272623005562 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 272623005563 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272623005564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272623005565 Predicted integral membrane protein [Function unknown]; Region: COG0762 272623005566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272623005567 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272623005568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623005569 catalytic residue [active] 272623005570 cell division protein FtsZ; Validated; Region: PRK09330 272623005571 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272623005572 nucleotide binding site [chemical binding]; other site 272623005573 SulA interaction site; other site 272623005574 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272623005575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272623005576 nucleotide binding site [chemical binding]; other site 272623005577 Cell division protein FtsA; Region: FtsA; pfam14450 272623005578 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 272623005579 EDD domain protein, DegV family; Region: DegV; TIGR00762 272623005580 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272623005581 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272623005582 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272623005583 FAD dependent oxidoreductase; Region: DAO; pfam01266 272623005584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623005585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623005586 active site 272623005587 catalytic tetrad [active] 272623005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623005589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623005590 putative substrate translocation pore; other site 272623005591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623005592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272623005593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272623005594 dimerization interface [polypeptide binding]; other site 272623005595 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623005596 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623005597 DNA binding residues [nucleotide binding] 272623005598 putative dimer interface [polypeptide binding]; other site 272623005599 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272623005600 trimer interface [polypeptide binding]; other site 272623005601 active site 272623005602 G bulge; other site 272623005603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623005604 Zn2+ binding site [ion binding]; other site 272623005605 Mg2+ binding site [ion binding]; other site 272623005606 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272623005607 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272623005608 dimer interface [polypeptide binding]; other site 272623005609 ADP-ribose binding site [chemical binding]; other site 272623005610 active site 272623005611 nudix motif; other site 272623005612 metal binding site [ion binding]; metal-binding site 272623005613 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272623005614 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272623005615 Substrate binding site; other site 272623005616 Mg++ binding site; other site 272623005617 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272623005618 active site 272623005619 substrate binding site [chemical binding]; other site 272623005620 CoA binding site [chemical binding]; other site 272623005621 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272623005622 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272623005623 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272623005624 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005625 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623005626 Integrase core domain; Region: rve; pfam00665 272623005627 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272623005628 16S/18S rRNA binding site [nucleotide binding]; other site 272623005629 S13e-L30e interaction site [polypeptide binding]; other site 272623005630 25S rRNA binding site [nucleotide binding]; other site 272623005631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272623005632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272623005633 active site 272623005634 ATP binding site [chemical binding]; other site 272623005635 substrate binding site [chemical binding]; other site 272623005636 activation loop (A-loop); other site 272623005637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272623005638 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005639 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005640 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272623005642 active site 272623005643 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272623005644 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 272623005645 putative RNA binding site [nucleotide binding]; other site 272623005646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623005647 S-adenosylmethionine binding site [chemical binding]; other site 272623005648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272623005649 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 272623005650 Predicted membrane protein [Function unknown]; Region: COG2261 272623005651 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272623005652 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272623005653 putative active site [active] 272623005654 substrate binding site [chemical binding]; other site 272623005655 putative cosubstrate binding site; other site 272623005656 catalytic site [active] 272623005657 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272623005658 substrate binding site [chemical binding]; other site 272623005659 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272623005660 dimer interface [polypeptide binding]; other site 272623005661 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272623005662 nudix motif; other site 272623005663 SnoaL-like domain; Region: SnoaL_2; pfam12680 272623005664 primosome assembly protein PriA; Validated; Region: PRK05580 272623005665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623005666 ATP binding site [chemical binding]; other site 272623005667 putative Mg++ binding site [ion binding]; other site 272623005668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623005669 nucleotide binding region [chemical binding]; other site 272623005670 ATP-binding site [chemical binding]; other site 272623005671 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272623005672 Guanylate kinase; Region: Guanylate_kin; pfam00625 272623005673 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272623005674 catalytic site [active] 272623005675 G-X2-G-X-G-K; other site 272623005676 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272623005677 phosphodiesterase; Provisional; Region: PRK12704 272623005678 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 272623005679 KH domain; Region: KH_1; pfam00013 272623005680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623005681 Zn2+ binding site [ion binding]; other site 272623005682 Mg2+ binding site [ion binding]; other site 272623005683 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272623005684 active site 272623005685 trimer interface [polypeptide binding]; other site 272623005686 allosteric site; other site 272623005687 active site lid [active] 272623005688 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272623005689 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272623005690 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272623005691 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272623005692 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272623005693 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272623005694 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272623005695 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272623005696 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272623005697 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272623005698 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272623005699 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272623005700 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 272623005701 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272623005702 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272623005703 CHAP domain; Region: CHAP; pfam05257 272623005704 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005705 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623005706 Integrase core domain; Region: rve; pfam00665 272623005707 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272623005708 intersubunit interface [polypeptide binding]; other site 272623005709 active site 272623005710 zinc binding site [ion binding]; other site 272623005711 Na+ binding site [ion binding]; other site 272623005712 Predicted membrane protein [Function unknown]; Region: COG2860 272623005713 UPF0126 domain; Region: UPF0126; pfam03458 272623005714 UPF0126 domain; Region: UPF0126; pfam03458 272623005715 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272623005716 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272623005717 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272623005718 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272623005719 active site 272623005720 dimer interface [polypeptide binding]; other site 272623005721 motif 1; other site 272623005722 motif 2; other site 272623005723 motif 3; other site 272623005724 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272623005725 anticodon binding site; other site 272623005726 ATP cone domain; Region: ATP-cone; pfam03477 272623005727 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 272623005728 dimer interface [polypeptide binding]; other site 272623005729 FMN binding site [chemical binding]; other site 272623005730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623005731 active site 272623005732 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272623005733 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272623005734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623005735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005736 homodimer interface [polypeptide binding]; other site 272623005737 catalytic residue [active] 272623005738 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623005739 homodimer interface [polypeptide binding]; other site 272623005740 substrate-cofactor binding pocket; other site 272623005741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005742 catalytic residue [active] 272623005743 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272623005744 proposed active site lysine [active] 272623005745 conserved cys residue [active] 272623005746 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 272623005747 nudix motif; other site 272623005748 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272623005749 active site 272623005750 catalytic residues [active] 272623005751 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272623005752 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272623005753 generic binding surface II; other site 272623005754 generic binding surface I; other site 272623005755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623005756 Zn2+ binding site [ion binding]; other site 272623005757 Mg2+ binding site [ion binding]; other site 272623005758 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 272623005759 RmuC family; Region: RmuC; pfam02646 272623005760 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272623005761 substrate binding site [chemical binding]; other site 272623005762 hexamer interface [polypeptide binding]; other site 272623005763 metal binding site [ion binding]; metal-binding site 272623005764 GTPase RsgA; Reviewed; Region: PRK00098 272623005765 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272623005766 RNA binding site [nucleotide binding]; other site 272623005767 homodimer interface [polypeptide binding]; other site 272623005768 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272623005769 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272623005770 GTP/Mg2+ binding site [chemical binding]; other site 272623005771 G4 box; other site 272623005772 G1 box; other site 272623005773 Switch I region; other site 272623005774 G2 box; other site 272623005775 G3 box; other site 272623005776 Switch II region; other site 272623005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623005778 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272623005779 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 272623005780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272623005781 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272623005782 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272623005783 putative tRNA-binding site [nucleotide binding]; other site 272623005784 B3/4 domain; Region: B3_4; pfam03483 272623005785 tRNA synthetase B5 domain; Region: B5; smart00874 272623005786 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272623005787 dimer interface [polypeptide binding]; other site 272623005788 motif 1; other site 272623005789 motif 3; other site 272623005790 motif 2; other site 272623005791 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272623005792 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272623005793 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272623005794 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272623005795 dimer interface [polypeptide binding]; other site 272623005796 motif 1; other site 272623005797 active site 272623005798 motif 2; other site 272623005799 motif 3; other site 272623005800 Phenolic Acid Decarboxylase; Region: PAD; cd14241 272623005801 active site 272623005802 dimer interface [polypeptide binding]; other site 272623005803 defective Bacteriophage bIL311; ps3 272623005804 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005805 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623005806 Integrase core domain; Region: rve; pfam00665 272623005807 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 272623005808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005809 non-specific DNA binding site [nucleotide binding]; other site 272623005810 salt bridge; other site 272623005811 sequence-specific DNA binding site [nucleotide binding]; other site 272623005812 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 272623005813 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 272623005814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005815 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623005816 Coenzyme A binding pocket [chemical binding]; other site 272623005817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272623005818 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005819 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623005820 Integrase core domain; Region: rve; pfam00665 272623005821 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 272623005822 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272623005823 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623005824 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272623005825 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272623005826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005827 non-specific DNA binding site [nucleotide binding]; other site 272623005828 salt bridge; other site 272623005829 sequence-specific DNA binding site [nucleotide binding]; other site 272623005830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005831 non-specific DNA binding site [nucleotide binding]; other site 272623005832 salt bridge; other site 272623005833 sequence-specific DNA binding site [nucleotide binding]; other site 272623005834 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272623005835 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272623005836 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623005837 Int/Topo IB signature motif; other site 272623005838 Predicted transcriptional regulators [Transcription]; Region: COG1695 272623005839 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272623005840 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 272623005841 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 272623005842 putative active site [active] 272623005843 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272623005844 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272623005845 Interdomain contacts; other site 272623005846 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272623005847 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272623005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 272623005849 Chitin binding domain; Region: Chitin_bind_3; pfam03067 272623005850 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272623005851 GDP-binding site [chemical binding]; other site 272623005852 ACT binding site; other site 272623005853 IMP binding site; other site 272623005854 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272623005855 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 272623005856 Uncharacterized conserved protein [Function unknown]; Region: COG5646 272623005857 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272623005858 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272623005859 dimerization interface [polypeptide binding]; other site 272623005860 domain crossover interface; other site 272623005861 redox-dependent activation switch; other site 272623005862 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272623005863 NADP+ binding site [chemical binding]; other site 272623005864 folate binding site [chemical binding]; other site 272623005865 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272623005866 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272623005867 FMN binding site [chemical binding]; other site 272623005868 active site 272623005869 catalytic residues [active] 272623005870 substrate binding site [chemical binding]; other site 272623005871 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623005872 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005873 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005874 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272623005875 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623005876 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005877 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005878 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272623005879 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623005880 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005881 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005882 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272623005883 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272623005884 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272623005885 dimer interface [polypeptide binding]; other site 272623005886 anticodon binding site; other site 272623005887 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272623005888 homodimer interface [polypeptide binding]; other site 272623005889 motif 1; other site 272623005890 active site 272623005891 motif 2; other site 272623005892 GAD domain; Region: GAD; pfam02938 272623005893 motif 3; other site 272623005894 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272623005895 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272623005896 dimer interface [polypeptide binding]; other site 272623005897 motif 1; other site 272623005898 active site 272623005899 motif 2; other site 272623005900 motif 3; other site 272623005901 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272623005902 anticodon binding site; other site 272623005903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005904 non-specific DNA binding site [nucleotide binding]; other site 272623005905 salt bridge; other site 272623005906 sequence-specific DNA binding site [nucleotide binding]; other site 272623005907 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623005908 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272623005909 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272623005910 Helix-turn-helix domain; Region: HTH_25; pfam13413 272623005911 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272623005912 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272623005913 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272623005914 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272623005915 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272623005916 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 272623005917 recF protein; Region: recf; TIGR00611 272623005918 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272623005919 Walker A/P-loop; other site 272623005920 ATP binding site [chemical binding]; other site 272623005921 Q-loop/lid; other site 272623005922 ABC transporter signature motif; other site 272623005923 Walker B; other site 272623005924 D-loop; other site 272623005925 H-loop/switch region; other site 272623005926 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272623005927 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623005928 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623005929 DNA binding residues [nucleotide binding] 272623005930 putative dimer interface [polypeptide binding]; other site 272623005931 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 272623005932 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272623005933 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272623005934 NAD binding site [chemical binding]; other site 272623005935 homodimer interface [polypeptide binding]; other site 272623005936 active site 272623005937 substrate binding site [chemical binding]; other site 272623005938 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 272623005939 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272623005940 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272623005941 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272623005942 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 272623005943 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 272623005944 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 272623005945 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 272623005946 galactokinase; Provisional; Region: PRK05322 272623005947 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272623005948 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623005949 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272623005950 active site 272623005951 catalytic residues [active] 272623005952 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623005953 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623005954 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623005955 putative active site [active] 272623005956 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623005957 active site 272623005958 catalytic tetrad [active] 272623005959 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 272623005960 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 272623005961 active site 272623005962 (T/H)XGH motif; other site 272623005963 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 272623005964 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272623005965 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 272623005966 NAD binding site [chemical binding]; other site 272623005967 ligand binding site [chemical binding]; other site 272623005968 catalytic site [active] 272623005969 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272623005970 putative protease; Provisional; Region: PRK15452 272623005971 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272623005972 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 272623005973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623005974 S-adenosylmethionine binding site [chemical binding]; other site 272623005975 CutC family; Region: CutC; pfam03932 272623005976 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 272623005977 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272623005978 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272623005979 Walker A/P-loop; other site 272623005980 ATP binding site [chemical binding]; other site 272623005981 Q-loop/lid; other site 272623005982 ABC transporter signature motif; other site 272623005983 Walker B; other site 272623005984 D-loop; other site 272623005985 H-loop/switch region; other site 272623005986 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 272623005987 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272623005988 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272623005989 putative active site [active] 272623005990 catalytic site [active] 272623005991 putative metal binding site [ion binding]; other site 272623005992 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272623005993 HIT family signature motif; other site 272623005994 catalytic residue [active] 272623005995 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272623005996 mRNA/rRNA interface [nucleotide binding]; other site 272623005997 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272623005998 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272623005999 23S rRNA interface [nucleotide binding]; other site 272623006000 L7/L12 interface [polypeptide binding]; other site 272623006001 putative thiostrepton binding site; other site 272623006002 L25 interface [polypeptide binding]; other site 272623006003 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272623006004 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623006005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623006006 motif II; other site 272623006007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272623006008 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 272623006009 ligand binding site [chemical binding]; other site 272623006010 flexible hinge region; other site 272623006011 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272623006012 putative switch regulator; other site 272623006013 non-specific DNA interactions [nucleotide binding]; other site 272623006014 DNA binding site [nucleotide binding] 272623006015 sequence specific DNA binding site [nucleotide binding]; other site 272623006016 putative cAMP binding site [chemical binding]; other site 272623006017 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006018 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623006019 Integrase core domain; Region: rve; pfam00665 272623006020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 272623006021 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272623006022 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272623006023 S1 domain; Region: S1_2; pfam13509 272623006024 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623006025 RNA binding site [nucleotide binding]; other site 272623006026 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272623006027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623006028 Coenzyme A binding pocket [chemical binding]; other site 272623006029 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272623006030 hinge region; other site 272623006031 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272623006032 putative nucleotide binding site [chemical binding]; other site 272623006033 uridine monophosphate binding site [chemical binding]; other site 272623006034 homohexameric interface [polypeptide binding]; other site 272623006035 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272623006036 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272623006037 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272623006038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272623006039 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272623006040 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272623006041 G1 box; other site 272623006042 putative GEF interaction site [polypeptide binding]; other site 272623006043 GTP/Mg2+ binding site [chemical binding]; other site 272623006044 Switch I region; other site 272623006045 G2 box; other site 272623006046 G3 box; other site 272623006047 Switch II region; other site 272623006048 G4 box; other site 272623006049 G5 box; other site 272623006050 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272623006051 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272623006052 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272623006053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623006054 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272623006055 Walker A/P-loop; other site 272623006056 ATP binding site [chemical binding]; other site 272623006057 Q-loop/lid; other site 272623006058 ABC transporter signature motif; other site 272623006059 Walker B; other site 272623006060 D-loop; other site 272623006061 H-loop/switch region; other site 272623006062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 272623006063 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272623006064 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 272623006065 LytTr DNA-binding domain; Region: LytTR; pfam04397 272623006066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 272623006067 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272623006068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272623006069 nucleotide binding site [chemical binding]; other site 272623006070 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623006071 Ferritin-like domain; Region: Ferritin; pfam00210 272623006072 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272623006073 dimerization interface [polypeptide binding]; other site 272623006074 DPS ferroxidase diiron center [ion binding]; other site 272623006075 ion pore; other site 272623006076 putative transposase OrfB; Reviewed; Region: PHA02517 272623006077 HTH-like domain; Region: HTH_21; pfam13276 272623006078 Integrase core domain; Region: rve; pfam00665 272623006079 Integrase core domain; Region: rve_3; pfam13683 272623006080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006081 Transposase; Region: HTH_Tnp_1; pfam01527 272623006082 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272623006083 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272623006084 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272623006085 active site 272623006086 DNA polymerase IV; Validated; Region: PRK02406 272623006087 DNA binding site [nucleotide binding] 272623006088 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 272623006089 putative deacylase active site [active] 272623006090 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 272623006091 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272623006092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623006093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623006094 homodimer interface [polypeptide binding]; other site 272623006095 catalytic residue [active] 272623006096 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623006097 putative substrate binding site [chemical binding]; other site 272623006098 nucleotide binding site [chemical binding]; other site 272623006099 nucleotide binding site [chemical binding]; other site 272623006100 homodimer interface [polypeptide binding]; other site 272623006101 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623006102 putative substrate binding site [chemical binding]; other site 272623006103 nucleotide binding site [chemical binding]; other site 272623006104 nucleotide binding site [chemical binding]; other site 272623006105 homodimer interface [polypeptide binding]; other site 272623006106 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 272623006107 ornithine carbamoyltransferase; Validated; Region: PRK02102 272623006108 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623006109 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272623006110 arginine deiminase; Provisional; Region: PRK01388 272623006111 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272623006112 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272623006113 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272623006114 active site 272623006115 HIGH motif; other site 272623006116 KMSK motif region; other site 272623006117 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272623006118 tRNA binding surface [nucleotide binding]; other site 272623006119 anticodon binding site; other site 272623006120 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272623006121 arginine repressor; Region: argR_whole; TIGR01529 272623006122 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272623006123 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272623006124 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623006125 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623006126 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623006127 SWIM zinc finger; Region: SWIM; pfam04434 272623006128 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272623006129 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272623006130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623006131 ATP binding site [chemical binding]; other site 272623006132 putative Mg++ binding site [ion binding]; other site 272623006133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623006134 nucleotide binding region [chemical binding]; other site 272623006135 ATP-binding site [chemical binding]; other site 272623006136 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272623006137 metal ion-dependent adhesion site (MIDAS); other site 272623006138 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272623006139 domain interaction interfaces [polypeptide binding]; other site 272623006140 Cna protein B-type domain; Region: Cna_B; pfam05738 272623006141 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 272623006142 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 272623006143 PYR/PP interface [polypeptide binding]; other site 272623006144 dimer interface [polypeptide binding]; other site 272623006145 tetramer interface [polypeptide binding]; other site 272623006146 TPP binding site [chemical binding]; other site 272623006147 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272623006148 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272623006149 TPP-binding site [chemical binding]; other site 272623006150 Beta-lactamase; Region: Beta-lactamase; pfam00144 272623006151 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272623006152 CppA C-terminal; Region: CppA_C; pfam14507 272623006153 CAAX protease self-immunity; Region: Abi; pfam02517 272623006154 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623006155 amphipathic channel; other site 272623006156 Asn-Pro-Ala signature motifs; other site 272623006157 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 272623006158 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 272623006159 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272623006160 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 272623006161 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272623006162 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272623006163 catalytic triad [active] 272623006164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623006165 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623006166 substrate binding pocket [chemical binding]; other site 272623006167 membrane-bound complex binding site; other site 272623006168 hinge residues; other site 272623006169 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 272623006170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623006171 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623006172 TrkA-N domain; Region: TrkA_N; pfam02254 272623006173 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272623006174 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272623006175 active site 272623006176 HIGH motif; other site 272623006177 KMSKS motif; other site 272623006178 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272623006179 catalytic triad [active] 272623006180 conserved cis-peptide bond; other site 272623006181 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 272623006182 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272623006183 active site 272623006184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272623006185 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272623006186 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272623006187 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272623006188 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272623006189 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272623006190 putative active site [active] 272623006191 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006192 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623006193 Integrase core domain; Region: rve; pfam00665 272623006194 Predicted membrane protein [Function unknown]; Region: COG3619 272623006195 DNA repair protein RadA; Provisional; Region: PRK11823 272623006196 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272623006197 Walker A motif/ATP binding site; other site 272623006198 ATP binding site [chemical binding]; other site 272623006199 Walker B motif; other site 272623006200 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272623006201 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623006202 metal-binding site [ion binding] 272623006203 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272623006204 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272623006205 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272623006206 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272623006207 alphaNTD homodimer interface [polypeptide binding]; other site 272623006208 alphaNTD - beta interaction site [polypeptide binding]; other site 272623006209 alphaNTD - beta' interaction site [polypeptide binding]; other site 272623006210 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272623006211 30S ribosomal protein S11; Validated; Region: PRK05309 272623006212 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272623006213 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 272623006214 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272623006215 rRNA binding site [nucleotide binding]; other site 272623006216 predicted 30S ribosome binding site; other site 272623006217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623006218 HTH-like domain; Region: HTH_21; pfam13276 272623006219 Integrase core domain; Region: rve; pfam00665 272623006220 Integrase core domain; Region: rve_3; pfam13683 272623006221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006222 Transposase; Region: HTH_Tnp_1; pfam01527 272623006223 putative transposase OrfB; Reviewed; Region: PHA02517 272623006224 HTH-like domain; Region: HTH_21; pfam13276 272623006225 Integrase core domain; Region: rve; pfam00665 272623006226 Integrase core domain; Region: rve_2; pfam13333 272623006227 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623006228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006229 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623006230 adenylate kinase; Reviewed; Region: adk; PRK00279 272623006231 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272623006232 AMP-binding site [chemical binding]; other site 272623006233 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272623006234 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272623006235 SecY translocase; Region: SecY; pfam00344 272623006236 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272623006237 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272623006238 23S rRNA binding site [nucleotide binding]; other site 272623006239 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272623006240 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272623006241 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272623006242 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272623006243 5S rRNA interface [nucleotide binding]; other site 272623006244 L27 interface [polypeptide binding]; other site 272623006245 23S rRNA interface [nucleotide binding]; other site 272623006246 L5 interface [polypeptide binding]; other site 272623006247 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272623006248 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272623006249 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272623006250 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272623006251 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272623006252 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272623006253 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272623006254 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272623006255 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272623006256 RNA binding site [nucleotide binding]; other site 272623006257 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272623006258 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272623006259 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272623006260 23S rRNA interface [nucleotide binding]; other site 272623006261 putative translocon interaction site; other site 272623006262 signal recognition particle (SRP54) interaction site; other site 272623006263 L23 interface [polypeptide binding]; other site 272623006264 trigger factor interaction site; other site 272623006265 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272623006266 23S rRNA interface [nucleotide binding]; other site 272623006267 5S rRNA interface [nucleotide binding]; other site 272623006268 putative antibiotic binding site [chemical binding]; other site 272623006269 L25 interface [polypeptide binding]; other site 272623006270 L27 interface [polypeptide binding]; other site 272623006271 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272623006272 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272623006273 G-X-X-G motif; other site 272623006274 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272623006275 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272623006276 putative translocon binding site; other site 272623006277 protein-rRNA interface [nucleotide binding]; other site 272623006278 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272623006279 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272623006280 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272623006281 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272623006282 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272623006283 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272623006284 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272623006285 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272623006286 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272623006287 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272623006288 putative efflux protein, MATE family; Region: matE; TIGR00797 272623006289 threonine synthase; Validated; Region: PRK09225 272623006290 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272623006291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623006292 catalytic residue [active] 272623006293 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272623006294 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272623006295 putative homodimer interface [polypeptide binding]; other site 272623006296 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272623006297 heterodimer interface [polypeptide binding]; other site 272623006298 homodimer interface [polypeptide binding]; other site 272623006299 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 272623006300 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272623006301 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272623006302 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 272623006303 catalytic triad [active] 272623006304 catalytic triad [active] 272623006305 oxyanion hole [active] 272623006306 Transglycosylase; Region: Transgly; pfam00912 272623006307 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272623006308 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272623006309 Predicted membrane protein [Function unknown]; Region: COG2323 272623006310 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 272623006311 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272623006312 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272623006313 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272623006314 active site 272623006315 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623006316 ABC-ATPase subunit interface; other site 272623006317 dimer interface [polypeptide binding]; other site 272623006318 putative PBP binding regions; other site 272623006319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272623006320 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272623006321 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272623006322 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272623006323 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272623006324 metal binding site [ion binding]; metal-binding site 272623006325 MarR family; Region: MarR_2; cl17246 272623006326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623006327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623006328 putative DNA binding site [nucleotide binding]; other site 272623006329 putative Zn2+ binding site [ion binding]; other site 272623006330 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 272623006331 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272623006332 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 272623006333 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272623006334 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272623006335 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272623006336 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272623006337 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272623006338 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272623006339 Walker A motif; other site 272623006340 ATP binding site [chemical binding]; other site 272623006341 Walker B motif; other site 272623006342 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272623006343 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 272623006344 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 272623006345 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272623006346 generic binding surface II; other site 272623006347 generic binding surface I; other site 272623006348 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272623006349 generic binding surface II; other site 272623006350 generic binding surface I; other site 272623006351 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272623006352 active site 272623006353 putative PHP Thumb interface [polypeptide binding]; other site 272623006354 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623006355 active site 272623006356 catalytic site [active] 272623006357 substrate binding site [chemical binding]; other site 272623006358 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272623006359 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272623006360 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272623006361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272623006362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623006363 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272623006364 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272623006365 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272623006366 dimer interface [polypeptide binding]; other site 272623006367 motif 1; other site 272623006368 active site 272623006369 motif 2; other site 272623006370 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272623006371 putative deacylase active site [active] 272623006372 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272623006373 active site 272623006374 motif 3; other site 272623006375 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272623006376 anticodon binding site; other site 272623006377 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272623006378 RIP metalloprotease RseP; Region: TIGR00054 272623006379 active site 272623006380 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272623006381 protein binding site [polypeptide binding]; other site 272623006382 putative substrate binding region [chemical binding]; other site 272623006383 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272623006384 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272623006385 active site 272623006386 dimer interface [polypeptide binding]; other site 272623006387 Preprotein translocase subunit; Region: YajC; cl00806 272623006388 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272623006389 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006390 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623006391 Integrase core domain; Region: rve; pfam00665 272623006392 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272623006393 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272623006394 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272623006395 protein binding site [polypeptide binding]; other site 272623006396 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272623006397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623006398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623006399 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272623006400 putative ADP-binding pocket [chemical binding]; other site 272623006401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 272623006402 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272623006403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006404 S-adenosylmethionine binding site [chemical binding]; other site 272623006405 DNA polymerase I; Provisional; Region: PRK05755 272623006406 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272623006407 active site 272623006408 metal binding site 1 [ion binding]; metal-binding site 272623006409 putative 5' ssDNA interaction site; other site 272623006410 metal binding site 3; metal-binding site 272623006411 metal binding site 2 [ion binding]; metal-binding site 272623006412 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272623006413 putative DNA binding site [nucleotide binding]; other site 272623006414 putative metal binding site [ion binding]; other site 272623006415 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272623006416 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272623006417 active site 272623006418 DNA binding site [nucleotide binding] 272623006419 catalytic site [active] 272623006420 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272623006421 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623006422 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272623006423 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623006424 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623006425 DNA binding site [nucleotide binding] 272623006426 domain linker motif; other site 272623006427 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272623006428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623006429 HTH-like domain; Region: HTH_21; pfam13276 272623006430 Integrase core domain; Region: rve; pfam00665 272623006431 Integrase core domain; Region: rve_3; pfam13683 272623006432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006433 Transposase; Region: HTH_Tnp_1; pfam01527 272623006434 putative transposase OrfB; Reviewed; Region: PHA02517 272623006435 HTH-like domain; Region: HTH_21; pfam13276 272623006436 Integrase core domain; Region: rve; pfam00665 272623006437 Integrase core domain; Region: rve_2; pfam13333 272623006438 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623006439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006440 Helix-turn-helix domain; Region: HTH_28; pfam13518 272623006441 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272623006442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623006443 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 272623006444 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272623006445 elongation factor Ts; Provisional; Region: tsf; PRK09377 272623006446 UBA/TS-N domain; Region: UBA; pfam00627 272623006447 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272623006448 rRNA interaction site [nucleotide binding]; other site 272623006449 S8 interaction site; other site 272623006450 putative laminin-1 binding site; other site 272623006451 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 272623006452 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272623006453 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272623006454 putative catalytic cysteine [active] 272623006455 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272623006456 putative active site [active] 272623006457 metal binding site [ion binding]; metal-binding site 272623006458 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272623006459 dimer interface [polypeptide binding]; other site 272623006460 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272623006461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006462 FeS/SAM binding site; other site 272623006463 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272623006464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006465 FeS/SAM binding site; other site 272623006466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006467 Helix-turn-helix domain; Region: HTH_19; pfam12844 272623006468 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623006469 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272623006470 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272623006471 protein binding site [polypeptide binding]; other site 272623006472 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272623006473 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272623006474 active site 272623006475 (T/H)XGH motif; other site 272623006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006477 S-adenosylmethionine binding site [chemical binding]; other site 272623006478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623006479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006480 putative substrate translocation pore; other site 272623006481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623006482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006483 putative substrate translocation pore; other site 272623006484 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272623006485 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272623006486 DNA binding residues [nucleotide binding] 272623006487 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 272623006488 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272623006489 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272623006490 active site 272623006491 dimer interface [polypeptide binding]; other site 272623006492 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272623006493 dimer interface [polypeptide binding]; other site 272623006494 active site 272623006495 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 272623006496 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272623006497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006498 NAD(P) binding site [chemical binding]; other site 272623006499 active site 272623006500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623006501 dimerization interface [polypeptide binding]; other site 272623006502 putative DNA binding site [nucleotide binding]; other site 272623006503 putative Zn2+ binding site [ion binding]; other site 272623006504 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272623006505 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272623006506 active site 272623006507 HIGH motif; other site 272623006508 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272623006509 KMSKS motif; other site 272623006510 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272623006511 tRNA binding surface [nucleotide binding]; other site 272623006512 anticodon binding site; other site 272623006513 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272623006514 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 272623006515 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 272623006516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 272623006517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272623006518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623006519 Coenzyme A binding pocket [chemical binding]; other site 272623006520 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 272623006521 TRAM domain; Region: TRAM; pfam01938 272623006522 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272623006523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006524 S-adenosylmethionine binding site [chemical binding]; other site 272623006525 legume lectins; Region: lectin_L-type; cl14058 272623006526 carbohydrate binding site [chemical binding]; other site 272623006527 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623006528 MucBP domain; Region: MucBP; pfam06458 272623006529 MucBP domain; Region: MucBP; pfam06458 272623006530 MucBP domain; Region: MucBP; pfam06458 272623006531 MucBP domain; Region: MucBP; pfam06458 272623006532 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272623006533 legume lectins; Region: lectin_L-type; cl14058 272623006534 homotetramer interaction site [polypeptide binding]; other site 272623006535 homodimer interaction site [polypeptide binding]; other site 272623006536 carbohydrate binding site [chemical binding]; other site 272623006537 recombination regulator RecX; Provisional; Region: recX; PRK14135 272623006538 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006539 Helix-turn-helix domain; Region: HTH_38; pfam13936 272623006540 Integrase core domain; Region: rve; pfam00665 272623006541 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272623006542 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272623006543 N- and C-terminal domain interface [polypeptide binding]; other site 272623006544 active site 272623006545 catalytic site [active] 272623006546 metal binding site [ion binding]; metal-binding site 272623006547 carbohydrate binding site [chemical binding]; other site 272623006548 ATP binding site [chemical binding]; other site 272623006549 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272623006550 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272623006551 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272623006552 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623006553 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623006554 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623006555 putative active site [active] 272623006556 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 272623006557 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272623006558 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272623006559 putative active site [active] 272623006560 putative metal binding site [ion binding]; other site 272623006561 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272623006562 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272623006563 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623006564 dimer interface [polypeptide binding]; other site 272623006565 ssDNA binding site [nucleotide binding]; other site 272623006566 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623006567 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272623006568 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272623006569 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 272623006570 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272623006571 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272623006572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623006573 Walker A motif; other site 272623006574 ATP binding site [chemical binding]; other site 272623006575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272623006576 Walker B motif; other site 272623006577 arginine finger; other site 272623006578 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 272623006579 Phosphotransferase enzyme family; Region: APH; pfam01636 272623006580 substrate binding site [chemical binding]; other site 272623006581 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272623006582 hypothetical protein; Provisional; Region: PRK07248 272623006583 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272623006584 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272623006585 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272623006586 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 272623006587 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623006588 DNA binding residues [nucleotide binding] 272623006589 putative dimer interface [polypeptide binding]; other site 272623006590 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272623006591 active site 272623006592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272623006593 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 272623006594 Walker A/P-loop; other site 272623006595 ATP binding site [chemical binding]; other site 272623006596 Q-loop/lid; other site 272623006597 ABC transporter signature motif; other site 272623006598 Walker B; other site 272623006599 D-loop; other site 272623006600 H-loop/switch region; other site 272623006601 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272623006602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623006603 non-specific DNA binding site [nucleotide binding]; other site 272623006604 salt bridge; other site 272623006605 sequence-specific DNA binding site [nucleotide binding]; other site 272623006606 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623006607 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272623006608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623006609 Walker A motif; other site 272623006610 ATP binding site [chemical binding]; other site 272623006611 Walker B motif; other site 272623006612 arginine finger; other site 272623006613 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272623006614 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272623006615 RuvA N terminal domain; Region: RuvA_N; pfam01330 272623006616 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272623006617 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272623006618 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272623006619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623006620 ATP binding site [chemical binding]; other site 272623006621 Mg2+ binding site [ion binding]; other site 272623006622 G-X-G motif; other site 272623006623 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272623006624 ATP binding site [chemical binding]; other site 272623006625 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272623006626 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272623006627 MutS domain I; Region: MutS_I; pfam01624 272623006628 MutS domain II; Region: MutS_II; pfam05188 272623006629 MutS domain III; Region: MutS_III; pfam05192 272623006630 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272623006631 Walker A/P-loop; other site 272623006632 ATP binding site [chemical binding]; other site 272623006633 Q-loop/lid; other site 272623006634 ABC transporter signature motif; other site 272623006635 Walker B; other site 272623006636 D-loop; other site 272623006637 H-loop/switch region; other site 272623006638 Predicted membrane protein [Function unknown]; Region: COG4550 272623006639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623006640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623006641 non-specific DNA binding site [nucleotide binding]; other site 272623006642 salt bridge; other site 272623006643 sequence-specific DNA binding site [nucleotide binding]; other site 272623006644 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272623006645 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272623006646 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272623006647 Predicted membrane protein [Function unknown]; Region: COG4272 272623006648 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272623006649 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272623006650 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272623006651 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272623006652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623006653 active site 272623006654 motif I; other site 272623006655 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272623006656 motif II; other site 272623006657 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623006658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 272623006659 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623006660 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272623006661 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 272623006662 putative active site [active] 272623006663 chaperone protein DnaJ; Provisional; Region: PRK14276 272623006664 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272623006665 HSP70 interaction site [polypeptide binding]; other site 272623006666 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272623006667 substrate binding site [polypeptide binding]; other site 272623006668 dimer interface [polypeptide binding]; other site 272623006669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 272623006670 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 272623006671 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 272623006672 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272623006673 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272623006674 active site 272623006675 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 272623006676 dimer interface [polypeptide binding]; other site 272623006677 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272623006678 Ligand Binding Site [chemical binding]; other site 272623006679 Molecular Tunnel; other site 272623006680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623006681 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 272623006682 Surface antigen [General function prediction only]; Region: COG3942 272623006683 CHAP domain; Region: CHAP; pfam05257 272623006684 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 272623006685 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272623006686 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272623006687 nudix motif; other site 272623006688 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272623006689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623006690 active site 272623006691 dimer interface [polypeptide binding]; other site 272623006692 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272623006693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272623006694 ligand binding site [chemical binding]; other site 272623006695 flexible hinge region; other site 272623006696 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272623006697 putative switch regulator; other site 272623006698 non-specific DNA interactions [nucleotide binding]; other site 272623006699 DNA binding site [nucleotide binding] 272623006700 sequence specific DNA binding site [nucleotide binding]; other site 272623006701 putative cAMP binding site [chemical binding]; other site 272623006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623006703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006704 putative substrate translocation pore; other site 272623006705 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623006706 Ligand Binding Site [chemical binding]; other site 272623006707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272623006708 nucleotide binding site [chemical binding]; other site 272623006709 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272623006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272623006711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272623006712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623006713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623006714 Protoglobin; Region: Protoglobin; pfam11563 272623006715 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272623006716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623006717 RNA binding surface [nucleotide binding]; other site 272623006718 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272623006719 active site 272623006720 uracil binding [chemical binding]; other site 272623006721 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272623006722 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272623006723 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272623006724 G1 box; other site 272623006725 GTP/Mg2+ binding site [chemical binding]; other site 272623006726 Switch I region; other site 272623006727 G2 box; other site 272623006728 Switch II region; other site 272623006729 G3 box; other site 272623006730 G4 box; other site 272623006731 G5 box; other site 272623006732 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272623006733 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272623006734 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272623006735 generic binding surface II; other site 272623006736 ssDNA binding site; other site 272623006737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623006738 ATP binding site [chemical binding]; other site 272623006739 putative Mg++ binding site [ion binding]; other site 272623006740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623006741 nucleotide binding region [chemical binding]; other site 272623006742 ATP-binding site [chemical binding]; other site 272623006743 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272623006744 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272623006745 PhnA protein; Region: PhnA; pfam03831 272623006746 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272623006747 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272623006748 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272623006749 phosphodiesterase; Provisional; Region: PRK12704 272623006750 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623006751 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272623006752 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623006753 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623006754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623006755 motif II; other site 272623006756 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623006757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623006758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272623006759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006760 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272623006761 NAD(P) binding site [chemical binding]; other site 272623006762 active site 272623006763 CAAX protease self-immunity; Region: Abi; pfam02517 272623006764 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272623006765 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272623006766 23S rRNA interface [nucleotide binding]; other site 272623006767 L3 interface [polypeptide binding]; other site 272623006768 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623006769 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272623006770 FtsX-like permease family; Region: FtsX; pfam02687 272623006771 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623006772 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272623006773 Walker A/P-loop; other site 272623006774 ATP binding site [chemical binding]; other site 272623006775 Q-loop/lid; other site 272623006776 ABC transporter signature motif; other site 272623006777 Walker B; other site 272623006778 D-loop; other site 272623006779 H-loop/switch region; other site 272623006780 ribonuclease HIII; Provisional; Region: PRK00996 272623006781 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 272623006782 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272623006783 RNA/DNA hybrid binding site [nucleotide binding]; other site 272623006784 active site 272623006785 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272623006786 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272623006787 Catalytic site [active] 272623006788 pur operon repressor; Provisional; Region: PRK09213 272623006789 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272623006790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623006791 active site 272623006792 elongation factor G; Reviewed; Region: PRK00007 272623006793 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272623006794 G1 box; other site 272623006795 putative GEF interaction site [polypeptide binding]; other site 272623006796 GTP/Mg2+ binding site [chemical binding]; other site 272623006797 Switch I region; other site 272623006798 G2 box; other site 272623006799 G3 box; other site 272623006800 Switch II region; other site 272623006801 G4 box; other site 272623006802 G5 box; other site 272623006803 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272623006804 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272623006805 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272623006806 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272623006807 30S ribosomal protein S7; Validated; Region: PRK05302 272623006808 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272623006809 S17 interaction site [polypeptide binding]; other site 272623006810 S8 interaction site; other site 272623006811 16S rRNA interaction site [nucleotide binding]; other site 272623006812 streptomycin interaction site [chemical binding]; other site 272623006813 23S rRNA interaction site [nucleotide binding]; other site 272623006814 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272623006815 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272623006816 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272623006817 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272623006818 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272623006819 Sugar transport protein; Region: Sugar_transport; pfam06800 272623006820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272623006821 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 272623006822 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 272623006823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006824 FeS/SAM binding site; other site