-- dump date 20140619_125719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 684738000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 684738000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738000003 Walker A motif; other site 684738000004 ATP binding site [chemical binding]; other site 684738000005 Walker B motif; other site 684738000006 arginine finger; other site 684738000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 684738000008 DnaA box-binding interface [nucleotide binding]; other site 684738000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 684738000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 684738000011 putative DNA binding surface [nucleotide binding]; other site 684738000012 dimer interface [polypeptide binding]; other site 684738000013 beta-clamp/clamp loader binding surface; other site 684738000014 beta-clamp/translesion DNA polymerase binding surface; other site 684738000015 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 684738000016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 684738000017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 684738000018 Part of AAA domain; Region: AAA_19; pfam13245 684738000019 Family description; Region: UvrD_C_2; pfam13538 684738000020 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 684738000021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738000022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000023 non-specific DNA binding site [nucleotide binding]; other site 684738000024 salt bridge; other site 684738000025 sequence-specific DNA binding site [nucleotide binding]; other site 684738000026 GTP-binding protein YchF; Reviewed; Region: PRK09601 684738000027 YchF GTPase; Region: YchF; cd01900 684738000028 G1 box; other site 684738000029 GTP/Mg2+ binding site [chemical binding]; other site 684738000030 Switch I region; other site 684738000031 G2 box; other site 684738000032 Switch II region; other site 684738000033 G3 box; other site 684738000034 G4 box; other site 684738000035 G5 box; other site 684738000036 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 684738000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000038 non-specific DNA binding site [nucleotide binding]; other site 684738000039 salt bridge; other site 684738000040 sequence-specific DNA binding site [nucleotide binding]; other site 684738000041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 684738000042 FtsX-like permease family; Region: FtsX; pfam02687 684738000043 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 684738000044 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738000045 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 684738000046 Walker A/P-loop; other site 684738000047 ATP binding site [chemical binding]; other site 684738000048 Q-loop/lid; other site 684738000049 ABC transporter signature motif; other site 684738000050 Walker B; other site 684738000051 D-loop; other site 684738000052 H-loop/switch region; other site 684738000053 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 684738000054 AAA domain; Region: AAA_17; pfam13207 684738000055 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 684738000056 putative active site [active] 684738000057 catalytic residue [active] 684738000058 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 684738000059 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 684738000060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738000061 ATP binding site [chemical binding]; other site 684738000062 putative Mg++ binding site [ion binding]; other site 684738000063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738000064 nucleotide binding region [chemical binding]; other site 684738000065 ATP-binding site [chemical binding]; other site 684738000066 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 684738000067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738000068 RNA binding surface [nucleotide binding]; other site 684738000069 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 684738000070 Septum formation initiator; Region: DivIC; cl17659 684738000071 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 684738000072 RNA binding site [nucleotide binding]; other site 684738000073 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 684738000074 SH3-like domain; Region: SH3_8; pfam13457 684738000075 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 684738000076 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 684738000077 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 684738000078 Ligand Binding Site [chemical binding]; other site 684738000079 TilS substrate C-terminal domain; Region: TilS_C; smart00977 684738000080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738000081 active site 684738000082 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 684738000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738000084 Walker A motif; other site 684738000085 ATP binding site [chemical binding]; other site 684738000086 Walker B motif; other site 684738000087 arginine finger; other site 684738000088 Peptidase family M41; Region: Peptidase_M41; pfam01434 684738000089 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 684738000090 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 684738000091 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 684738000092 active site 684738000093 P-loop; other site 684738000094 phosphorylation site [posttranslational modification] 684738000095 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 684738000096 active site 684738000097 P-loop; other site 684738000098 phosphorylation site [posttranslational modification] 684738000099 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 684738000100 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 684738000101 PRD domain; Region: PRD; pfam00874 684738000102 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 684738000103 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 684738000104 active site 684738000105 phosphorylation site [posttranslational modification] 684738000106 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 684738000107 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 684738000108 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 684738000109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 684738000110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000111 Coenzyme A binding pocket [chemical binding]; other site 684738000112 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 684738000113 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 684738000114 Sulfate transporter family; Region: Sulfate_transp; pfam00916 684738000115 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 684738000116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000117 Coenzyme A binding pocket [chemical binding]; other site 684738000118 aromatic amino acid aminotransferase; Validated; Region: PRK07309 684738000119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738000121 homodimer interface [polypeptide binding]; other site 684738000122 catalytic residue [active] 684738000123 Recombination protein O N terminal; Region: RecO_N; pfam11967 684738000124 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 684738000125 Recombination protein O C terminal; Region: RecO_C; pfam02565 684738000126 Helix-turn-helix domain; Region: HTH_19; pfam12844 684738000127 non-specific DNA binding site [nucleotide binding]; other site 684738000128 salt bridge; other site 684738000129 sequence-specific DNA binding site [nucleotide binding]; other site 684738000130 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 684738000131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 684738000132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738000133 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738000134 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 684738000135 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 684738000136 E3 interaction surface; other site 684738000137 lipoyl attachment site [posttranslational modification]; other site 684738000138 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 684738000139 E3 interaction surface; other site 684738000140 lipoyl attachment site [posttranslational modification]; other site 684738000141 e3 binding domain; Region: E3_binding; pfam02817 684738000142 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 684738000143 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 684738000144 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 684738000145 TPP binding site [chemical binding]; other site 684738000146 alpha subunit interface [polypeptide binding]; other site 684738000147 heterodimer interface [polypeptide binding]; other site 684738000148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 684738000149 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 684738000150 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 684738000151 tetramer interface [polypeptide binding]; other site 684738000152 TPP-binding site [chemical binding]; other site 684738000153 heterodimer interface [polypeptide binding]; other site 684738000154 phosphorylation loop region [posttranslational modification] 684738000155 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 684738000156 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 684738000157 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 684738000158 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 684738000159 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 684738000160 active site 684738000161 catalytic site [active] 684738000162 metal binding site [ion binding]; metal-binding site 684738000163 dimer interface [polypeptide binding]; other site 684738000164 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 684738000165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738000166 Zn2+ binding site [ion binding]; other site 684738000167 Mg2+ binding site [ion binding]; other site 684738000168 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 684738000169 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 684738000170 active site 684738000171 HIGH motif; other site 684738000172 dimer interface [polypeptide binding]; other site 684738000173 KMSKS motif; other site 684738000174 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 684738000175 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 684738000176 putative phosphate acyltransferase; Provisional; Region: PRK05331 684738000177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 684738000178 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738000179 active site 684738000180 motif I; other site 684738000181 motif II; other site 684738000182 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738000183 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 684738000184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738000185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738000186 ABC transporter; Region: ABC_tran_2; pfam12848 684738000187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738000188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000189 non-specific DNA binding site [nucleotide binding]; other site 684738000190 salt bridge; other site 684738000191 sequence-specific DNA binding site [nucleotide binding]; other site 684738000192 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738000193 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 684738000194 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 684738000195 homodimer interface [polypeptide binding]; other site 684738000196 substrate-cofactor binding pocket; other site 684738000197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738000198 catalytic residue [active] 684738000199 short chain dehydrogenase; Validated; Region: PRK06182 684738000200 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 684738000201 NADP binding site [chemical binding]; other site 684738000202 active site 684738000203 steroid binding site; other site 684738000204 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738000205 Ligand Binding Site [chemical binding]; other site 684738000206 Predicted esterase [General function prediction only]; Region: COG0400 684738000207 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 684738000208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 684738000209 Zn binding site [ion binding]; other site 684738000210 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 684738000211 Zn binding site [ion binding]; other site 684738000212 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 684738000213 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 684738000214 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 684738000215 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 684738000216 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738000217 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738000218 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 684738000219 ParB-like nuclease domain; Region: ParBc; pfam02195 684738000220 KorB domain; Region: KorB; pfam08535 684738000221 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 684738000222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738000223 Walker A motif; other site 684738000224 ATP binding site [chemical binding]; other site 684738000225 Walker B motif; other site 684738000226 arginine finger; other site 684738000227 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 684738000228 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 684738000229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000230 Coenzyme A binding pocket [chemical binding]; other site 684738000231 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 684738000232 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 684738000233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738000234 Walker A/P-loop; other site 684738000235 ATP binding site [chemical binding]; other site 684738000236 Q-loop/lid; other site 684738000237 ABC transporter signature motif; other site 684738000238 Walker B; other site 684738000239 D-loop; other site 684738000240 H-loop/switch region; other site 684738000241 ABC transporter; Region: ABC_tran_2; pfam12848 684738000242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738000243 Hypothetical protein, N-terminus; frameshift 684738000244 Hypothetical protein, C-terminus; frameshift 684738000245 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 684738000246 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 684738000247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738000248 S-adenosylmethionine binding site [chemical binding]; other site 684738000249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 684738000250 RNA methyltransferase, RsmE family; Region: TIGR00046 684738000251 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 684738000252 putative active site [active] 684738000253 putative metal binding site [ion binding]; other site 684738000254 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 684738000255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738000256 Zn2+ binding site [ion binding]; other site 684738000257 Mg2+ binding site [ion binding]; other site 684738000258 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 684738000259 synthetase active site [active] 684738000260 NTP binding site [chemical binding]; other site 684738000261 metal binding site [ion binding]; metal-binding site 684738000262 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 684738000263 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 684738000264 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 684738000265 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 684738000266 Ligand binding site; other site 684738000267 Putative Catalytic site; other site 684738000268 DXD motif; other site 684738000269 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 684738000270 putative active site [active] 684738000271 dimerization interface [polypeptide binding]; other site 684738000272 putative tRNAtyr binding site [nucleotide binding]; other site 684738000273 Predicted integral membrane protein [Function unknown]; Region: COG3548 684738000274 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 684738000275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738000276 amino acid transporter; Region: 2A0306; TIGR00909 684738000277 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 684738000278 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 684738000279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 684738000280 putative acyl-acceptor binding pocket; other site 684738000281 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738000282 MarR family; Region: MarR_2; cl17246 684738000283 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 684738000284 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 684738000285 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 684738000286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738000287 nucleotide binding region [chemical binding]; other site 684738000288 ATP-binding site [chemical binding]; other site 684738000289 SEC-C motif; Region: SEC-C; pfam02810 684738000290 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 684738000291 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 684738000292 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 684738000293 dimerization domain swap beta strand [polypeptide binding]; other site 684738000294 regulatory protein interface [polypeptide binding]; other site 684738000295 active site 684738000296 regulatory phosphorylation site [posttranslational modification]; other site 684738000297 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 684738000298 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 684738000299 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 684738000300 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 684738000301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 684738000302 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 684738000303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 684738000304 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 684738000305 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 684738000306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738000307 putative substrate translocation pore; other site 684738000308 CAAX protease self-immunity; Region: Abi; pfam02517 684738000309 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 684738000310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 684738000311 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738000312 Walker A/P-loop; other site 684738000313 ATP binding site [chemical binding]; other site 684738000314 Q-loop/lid; other site 684738000315 ABC transporter signature motif; other site 684738000316 Walker B; other site 684738000317 D-loop; other site 684738000318 H-loop/switch region; other site 684738000319 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 684738000320 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 684738000321 active site 684738000322 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 684738000323 putative active site [active] 684738000324 putative metal binding residues [ion binding]; other site 684738000325 signature motif; other site 684738000326 putative triphosphate binding site [ion binding]; other site 684738000327 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 684738000328 dimerization interface [polypeptide binding]; other site 684738000329 active site 684738000330 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 684738000331 classical (c) SDRs; Region: SDR_c; cd05233 684738000332 NAD(P) binding site [chemical binding]; other site 684738000333 active site 684738000334 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 684738000335 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 684738000336 TMP-binding site; other site 684738000337 ATP-binding site [chemical binding]; other site 684738000338 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 684738000339 active site 684738000340 dimer interface [polypeptide binding]; other site 684738000341 Domain of unknown function (DUF955); Region: DUF955; cl01076 684738000342 putative transposase OrfB; Reviewed; Region: PHA02517 684738000343 HTH-like domain; Region: HTH_21; pfam13276 684738000344 Integrase core domain; Region: rve; pfam00665 684738000345 Integrase core domain; Region: rve_3; pfam13683 684738000346 Transposase; Region: HTH_Tnp_1; pfam01527 684738000347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738000348 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738000349 argininosuccinate synthase; Provisional; Region: PRK13820 684738000350 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 684738000351 ANP binding site [chemical binding]; other site 684738000352 Substrate Binding Site II [chemical binding]; other site 684738000353 Substrate Binding Site I [chemical binding]; other site 684738000354 argininosuccinate lyase; Provisional; Region: PRK00855 684738000355 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 684738000356 active sites [active] 684738000357 tetramer interface [polypeptide binding]; other site 684738000358 drug efflux system protein MdtG; Provisional; Region: PRK09874 684738000359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738000360 putative substrate translocation pore; other site 684738000361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738000362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738000363 WHG domain; Region: WHG; pfam13305 684738000364 ribonuclease P; Reviewed; Region: rnpA; PRK00499 684738000365 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 684738000366 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 684738000367 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 684738000368 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 684738000369 G-X-X-G motif; other site 684738000370 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 684738000371 RxxxH motif; other site 684738000372 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 684738000373 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 684738000374 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 684738000375 active site 684738000376 catalytic tetrad [active] 684738000377 hypothetical protein; Provisional; Region: PRK05473 684738000378 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 684738000379 hypothetical protein; Provisional; Region: PRK13678 684738000380 Predicted integral membrane protein [Function unknown]; Region: COG3548 684738000381 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 684738000382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738000383 NAD(P) binding site [chemical binding]; other site 684738000384 active site 684738000385 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 684738000386 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 684738000387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738000388 NAD(P) binding site [chemical binding]; other site 684738000389 active site 684738000390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738000391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738000392 putative DNA binding site [nucleotide binding]; other site 684738000393 putative Zn2+ binding site [ion binding]; other site 684738000394 glycogen branching enzyme; Provisional; Region: PRK12313 684738000395 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 684738000396 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 684738000397 active site 684738000398 catalytic site [active] 684738000399 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 684738000400 Collagen adhesion protein, LPXTG-anchored, N-terminus; frameshift 684738000401 Collagen adhesion protein, LPXTG-anchored, C-terminus; frameshift 684738000402 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738000403 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 684738000404 catalytic triad [active] 684738000405 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 684738000406 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 684738000407 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 684738000408 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 684738000409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 684738000410 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 684738000411 Bacterial sugar transferase; Region: Bac_transf; pfam02397 684738000412 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 684738000413 putative ADP-binding pocket [chemical binding]; other site 684738000414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738000415 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738000416 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 684738000417 Probable Catalytic site; other site 684738000418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738000419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 684738000420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 684738000421 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 684738000422 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 684738000423 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 684738000424 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 684738000425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738000426 DNA binding site [nucleotide binding] 684738000427 active site 684738000428 Int/Topo IB signature motif; other site 684738000429 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 684738000430 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 684738000431 Protein of unknown function (DUF975); Region: DUF975; cl10504 684738000432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738000433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738000434 putative substrate translocation pore; other site 684738000435 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 684738000436 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 684738000437 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 684738000438 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 684738000439 aminotransferase AlaT; Validated; Region: PRK09265 684738000440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738000441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738000442 homodimer interface [polypeptide binding]; other site 684738000443 catalytic residue [active] 684738000444 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 684738000445 CodY GAF-like domain; Region: CodY; pfam06018 684738000446 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 684738000447 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 684738000448 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 684738000449 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 684738000450 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 684738000451 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 684738000452 nudix motif; other site 684738000453 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 684738000454 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 684738000455 GatB domain; Region: GatB_Yqey; pfam02637 684738000456 amidase; Provisional; Region: PRK06529 684738000457 Amidase; Region: Amidase; cl11426 684738000458 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 684738000459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 684738000460 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738000461 DNA-binding site [nucleotide binding]; DNA binding site 684738000462 RNA-binding motif; other site 684738000463 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 684738000464 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 684738000465 Rhomboid family; Region: Rhomboid; pfam01694 684738000466 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 684738000467 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 684738000468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 684738000469 Uncharacterized conserved protein [Function unknown]; Region: COG3589 684738000470 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 684738000471 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 684738000472 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 684738000473 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738000474 beta-galactosidase; Region: BGL; TIGR03356 684738000475 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 684738000476 trimer interface [polypeptide binding]; other site 684738000477 active site 684738000478 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 684738000479 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 684738000480 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 684738000481 active site 684738000482 metal binding site [ion binding]; metal-binding site 684738000483 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 684738000484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 684738000485 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 684738000486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738000487 FeS/SAM binding site; other site 684738000488 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 684738000489 dimer interface [polypeptide binding]; other site 684738000490 FMN binding site [chemical binding]; other site 684738000491 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 684738000492 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 684738000493 substrate binding pocket [chemical binding]; other site 684738000494 chain length determination region; other site 684738000495 substrate-Mg2+ binding site; other site 684738000496 catalytic residues [active] 684738000497 aspartate-rich region 1; other site 684738000498 active site lid residues [active] 684738000499 aspartate-rich region 2; other site 684738000500 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 684738000501 UbiA prenyltransferase family; Region: UbiA; pfam01040 684738000502 CAAX protease self-immunity; Region: Abi; pfam02517 684738000503 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 684738000504 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 684738000505 G1 box; other site 684738000506 GTP/Mg2+ binding site [chemical binding]; other site 684738000507 Switch I region; other site 684738000508 G2 box; other site 684738000509 G3 box; other site 684738000510 Switch II region; other site 684738000511 G4 box; other site 684738000512 G5 box; other site 684738000513 Nucleoside recognition; Region: Gate; pfam07670 684738000514 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 684738000515 Nucleoside recognition; Region: Gate; pfam07670 684738000516 FeoA domain; Region: FeoA; pfam04023 684738000517 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 684738000518 methionine sulfoxide reductase B; Provisional; Region: PRK00222 684738000519 SelR domain; Region: SelR; pfam01641 684738000520 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 684738000521 DAK2 domain; Region: Dak2; pfam02734 684738000522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 684738000523 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 684738000524 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 684738000525 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 684738000526 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 684738000527 substrate binding site; other site 684738000528 tetramer interface; other site 684738000529 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 684738000530 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 684738000531 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 684738000532 NAD binding site [chemical binding]; other site 684738000533 substrate binding site [chemical binding]; other site 684738000534 homodimer interface [polypeptide binding]; other site 684738000535 active site 684738000536 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 684738000537 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 684738000538 NADP binding site [chemical binding]; other site 684738000539 active site 684738000540 putative substrate binding site [chemical binding]; other site 684738000541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738000542 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 684738000543 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 684738000544 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738000545 Probable Catalytic site; other site 684738000546 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 684738000547 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 684738000548 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 684738000549 Walker A/P-loop; other site 684738000550 ATP binding site [chemical binding]; other site 684738000551 Q-loop/lid; other site 684738000552 ABC transporter signature motif; other site 684738000553 Walker B; other site 684738000554 D-loop; other site 684738000555 H-loop/switch region; other site 684738000556 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 684738000557 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 684738000558 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738000559 active site 684738000560 Domain of unknown function (DUF947); Region: DUF947; pfam06102 684738000561 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 684738000562 Predicted membrane protein [Function unknown]; Region: COG4713 684738000563 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738000564 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 684738000565 Ligand binding site; other site 684738000566 Putative Catalytic site; other site 684738000567 DXD motif; other site 684738000568 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 684738000569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 684738000570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738000571 NAD(P) binding site [chemical binding]; other site 684738000572 active site 684738000573 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 684738000574 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 684738000575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738000576 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 684738000577 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 684738000578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738000579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738000580 active site 684738000581 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738000582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738000583 active site 684738000584 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 684738000585 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 684738000586 active site 684738000587 catalytic site [active] 684738000588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738000589 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 684738000590 active site 684738000591 nucleotide binding site [chemical binding]; other site 684738000592 HIGH motif; other site 684738000593 KMSKS motif; other site 684738000594 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 684738000595 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 684738000596 active site 684738000597 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 684738000598 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 684738000599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 684738000600 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 684738000601 active site 684738000602 GTPase YqeH; Provisional; Region: PRK13796 684738000603 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 684738000604 GTP/Mg2+ binding site [chemical binding]; other site 684738000605 G4 box; other site 684738000606 G5 box; other site 684738000607 G1 box; other site 684738000608 Switch I region; other site 684738000609 G2 box; other site 684738000610 G3 box; other site 684738000611 Switch II region; other site 684738000612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 684738000613 nudix motif; other site 684738000614 GTPases [General function prediction only]; Region: HflX; COG2262 684738000615 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 684738000616 HflX GTPase family; Region: HflX; cd01878 684738000617 G1 box; other site 684738000618 GTP/Mg2+ binding site [chemical binding]; other site 684738000619 Switch I region; other site 684738000620 G2 box; other site 684738000621 G3 box; other site 684738000622 Switch II region; other site 684738000623 G4 box; other site 684738000624 G5 box; other site 684738000625 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 684738000626 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 684738000627 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 684738000628 active site 684738000629 (T/H)XGH motif; other site 684738000630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738000631 Zn2+ binding site [ion binding]; other site 684738000632 Mg2+ binding site [ion binding]; other site 684738000633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000634 Coenzyme A binding pocket [chemical binding]; other site 684738000635 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 684738000636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738000637 S-adenosylmethionine binding site [chemical binding]; other site 684738000638 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 684738000639 hypothetical protein; Provisional; Region: PRK13670 684738000640 hypothetical protein; Provisional; Region: PRK12378 684738000641 Uncharacterized conserved protein [Function unknown]; Region: COG4832 684738000642 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 684738000643 ligand binding site [chemical binding]; other site 684738000644 active site 684738000645 UGI interface [polypeptide binding]; other site 684738000646 catalytic site [active] 684738000647 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 684738000648 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 684738000649 putative NAD(P) binding site [chemical binding]; other site 684738000650 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 684738000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738000652 Multidrug resistance protein B, C-terminal fragment; frameshift 684738000653 Multidrug resistance protein B, N-terminal fragment; frameshift 684738000654 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 684738000655 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 684738000656 DNA binding residues [nucleotide binding] 684738000657 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 684738000658 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738000659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738000660 active site 684738000661 motif I; other site 684738000662 motif II; other site 684738000663 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738000664 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 684738000665 Phosphoglycerate kinase; Region: PGK; pfam00162 684738000666 substrate binding site [chemical binding]; other site 684738000667 hinge regions; other site 684738000668 ADP binding site [chemical binding]; other site 684738000669 catalytic site [active] 684738000670 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 684738000671 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 684738000672 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 684738000673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738000674 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 684738000675 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 684738000676 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 684738000677 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 684738000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 684738000679 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 684738000680 amphipathic channel; other site 684738000681 Asn-Pro-Ala signature motifs; other site 684738000682 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 684738000683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738000684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738000685 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 684738000686 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738000687 Walker A/P-loop; other site 684738000688 ATP binding site [chemical binding]; other site 684738000689 Q-loop/lid; other site 684738000690 ABC transporter signature motif; other site 684738000691 Walker B; other site 684738000692 D-loop; other site 684738000693 H-loop/switch region; other site 684738000694 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 684738000695 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 684738000696 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 684738000697 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 684738000698 putative RNA binding site [nucleotide binding]; other site 684738000699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 684738000700 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 684738000701 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 684738000702 HI0933-like protein; Region: HI0933_like; pfam03486 684738000703 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 684738000704 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 684738000705 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 684738000706 putative substrate binding site [chemical binding]; other site 684738000707 putative ATP binding site [chemical binding]; other site 684738000708 Phage envelope protein [General function prediction only]; Region: COG5562 684738000709 Protein of unknown function (DUF805); Region: DUF805; pfam05656 684738000710 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738000711 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738000712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738000713 Walker A/P-loop; other site 684738000714 ATP binding site [chemical binding]; other site 684738000715 Q-loop/lid; other site 684738000716 ABC transporter signature motif; other site 684738000717 Walker B; other site 684738000718 D-loop; other site 684738000719 H-loop/switch region; other site 684738000720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738000721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738000722 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 684738000723 Walker A/P-loop; other site 684738000724 ATP binding site [chemical binding]; other site 684738000725 Q-loop/lid; other site 684738000726 ABC transporter signature motif; other site 684738000727 Walker B; other site 684738000728 D-loop; other site 684738000729 H-loop/switch region; other site 684738000730 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 684738000731 putative oxidoreductase; Provisional; Region: PRK10206 684738000732 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 684738000733 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 684738000734 S-ribosylhomocysteinase; Provisional; Region: PRK02260 684738000735 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 684738000736 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 684738000737 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 684738000738 active site 684738000739 catalytic tetrad [active] 684738000740 Isochorismatase family; Region: Isochorismatase; pfam00857 684738000741 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 684738000742 catalytic triad [active] 684738000743 conserved cis-peptide bond; other site 684738000744 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 684738000745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738000746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738000747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738000748 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 684738000749 ATP cone domain; Region: ATP-cone; pfam03477 684738000750 Class III ribonucleotide reductase; Region: RNR_III; cd01675 684738000751 effector binding site; other site 684738000752 active site 684738000753 Zn binding site [ion binding]; other site 684738000754 glycine loop; other site 684738000755 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 684738000756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738000757 FeS/SAM binding site; other site 684738000758 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 684738000759 enolase; Provisional; Region: eno; PRK00077 684738000760 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 684738000761 dimer interface [polypeptide binding]; other site 684738000762 metal binding site [ion binding]; metal-binding site 684738000763 substrate binding pocket [chemical binding]; other site 684738000764 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738000765 DNA-binding site [nucleotide binding]; DNA binding site 684738000766 RNA-binding motif; other site 684738000767 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738000768 DNA-binding site [nucleotide binding]; DNA binding site 684738000769 RNA-binding motif; other site 684738000770 Predicted membrane protein [Function unknown]; Region: COG2261 684738000771 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 684738000772 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 684738000773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 684738000774 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 684738000775 Cl binding site [ion binding]; other site 684738000776 oligomer interface [polypeptide binding]; other site 684738000777 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 684738000778 putative active site [active] 684738000779 putative ligand binding site [chemical binding]; other site 684738000780 putative NAD(P) binding site [chemical binding]; other site 684738000781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738000782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000783 non-specific DNA binding site [nucleotide binding]; other site 684738000784 salt bridge; other site 684738000785 sequence-specific DNA binding site [nucleotide binding]; other site 684738000786 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 684738000787 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 684738000788 active site 684738000789 homodimer interface [polypeptide binding]; other site 684738000790 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 684738000791 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 684738000792 DXD motif; other site 684738000793 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 684738000794 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 684738000795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738000796 Walker A/P-loop; other site 684738000797 ATP binding site [chemical binding]; other site 684738000798 Q-loop/lid; other site 684738000799 ABC transporter signature motif; other site 684738000800 Walker B; other site 684738000801 D-loop; other site 684738000802 H-loop/switch region; other site 684738000803 Predicted transcriptional regulators [Transcription]; Region: COG1725 684738000804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738000805 DNA-binding site [nucleotide binding]; DNA binding site 684738000806 Domain of unknown function (DUF955); Region: DUF955; pfam06114 684738000807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738000808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000809 non-specific DNA binding site [nucleotide binding]; other site 684738000810 salt bridge; other site 684738000811 sequence-specific DNA binding site [nucleotide binding]; other site 684738000812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738000813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000814 non-specific DNA binding site [nucleotide binding]; other site 684738000815 salt bridge; other site 684738000816 sequence-specific DNA binding site [nucleotide binding]; other site 684738000817 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 684738000818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 684738000819 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 684738000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000821 non-specific DNA binding site [nucleotide binding]; other site 684738000822 salt bridge; other site 684738000823 sequence-specific DNA binding site [nucleotide binding]; other site 684738000824 Replication initiation factor; Region: Rep_trans; pfam02486 684738000825 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 684738000826 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 684738000827 TcpE family; Region: TcpE; pfam12648 684738000828 AAA-like domain; Region: AAA_10; pfam12846 684738000829 Copper resistance protein D; Region: CopD; pfam05425 684738000830 CHAP domain; Region: CHAP; pfam05257 684738000831 Antirestriction protein (ArdA); Region: ArdA; cl01953 684738000832 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 684738000833 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 684738000834 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 684738000835 Int/Topo IB signature motif; other site 684738000836 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 684738000837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738000838 AAA domain; Region: AAA_21; pfam13304 684738000839 Walker A/P-loop; other site 684738000840 ATP binding site [chemical binding]; other site 684738000841 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 684738000842 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 684738000843 Walker A/P-loop; other site 684738000844 ATP binding site [chemical binding]; other site 684738000845 Q-loop/lid; other site 684738000846 ABC transporter signature motif; other site 684738000847 Walker B; other site 684738000848 D-loop; other site 684738000849 H-loop/switch region; other site 684738000850 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 684738000851 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 684738000852 Walker A/P-loop; other site 684738000853 ATP binding site [chemical binding]; other site 684738000854 Q-loop/lid; other site 684738000855 ABC transporter signature motif; other site 684738000856 Walker B; other site 684738000857 D-loop; other site 684738000858 H-loop/switch region; other site 684738000859 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 684738000860 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 684738000861 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 684738000862 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 684738000863 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 684738000864 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 684738000865 putative trimer interface [polypeptide binding]; other site 684738000866 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 684738000867 putative CoA binding site [chemical binding]; other site 684738000868 putative trimer interface [polypeptide binding]; other site 684738000869 putative CoA binding site [chemical binding]; other site 684738000870 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 684738000871 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 684738000872 metal binding site [ion binding]; metal-binding site 684738000873 putative dimer interface [polypeptide binding]; other site 684738000874 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 684738000875 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 684738000876 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 684738000877 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 684738000878 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 684738000879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738000880 RNA binding surface [nucleotide binding]; other site 684738000881 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 684738000882 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 684738000883 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 684738000884 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 684738000885 RNA binding site [nucleotide binding]; other site 684738000886 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 684738000887 hypothetical protein; Provisional; Region: PRK04351 684738000888 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 684738000889 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 684738000890 active site 684738000891 purine riboside binding site [chemical binding]; other site 684738000892 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 684738000893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 684738000894 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 684738000895 hypothetical protein; Provisional; Region: PRK13667 684738000896 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 684738000897 Glycoprotease family; Region: Peptidase_M22; pfam00814 684738000898 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 684738000899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000900 Coenzyme A binding pocket [chemical binding]; other site 684738000901 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 684738000902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738000903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 684738000904 Coenzyme A binding pocket [chemical binding]; other site 684738000905 UGMP family protein; Validated; Region: PRK09604 684738000906 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 684738000907 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 684738000908 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 684738000909 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 684738000910 Walker A/P-loop; other site 684738000911 ATP binding site [chemical binding]; other site 684738000912 Q-loop/lid; other site 684738000913 ABC transporter signature motif; other site 684738000914 Walker B; other site 684738000915 D-loop; other site 684738000916 H-loop/switch region; other site 684738000917 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 684738000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738000919 dimer interface [polypeptide binding]; other site 684738000920 conserved gate region; other site 684738000921 putative PBP binding loops; other site 684738000922 ABC-ATPase subunit interface; other site 684738000923 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 684738000924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738000925 dimer interface [polypeptide binding]; other site 684738000926 conserved gate region; other site 684738000927 ABC-ATPase subunit interface; other site 684738000928 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 684738000929 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 684738000930 active site 684738000931 metal binding site [ion binding]; metal-binding site 684738000932 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 684738000933 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 684738000934 dimer interface [polypeptide binding]; other site 684738000935 catalytic triad [active] 684738000936 peroxidatic and resolving cysteines [active] 684738000937 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 684738000938 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 684738000939 Zn binding site [ion binding]; other site 684738000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738000941 putative substrate translocation pore; other site 684738000942 H+ Antiporter protein; Region: 2A0121; TIGR00900 684738000943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738000944 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 684738000945 Cation efflux family; Region: Cation_efflux; pfam01545 684738000946 Predicted transcriptional regulators [Transcription]; Region: COG1695 684738000947 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 684738000948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738000949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000950 non-specific DNA binding site [nucleotide binding]; other site 684738000951 salt bridge; other site 684738000952 sequence-specific DNA binding site [nucleotide binding]; other site 684738000953 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738000954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738000955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738000956 Walker A/P-loop; other site 684738000957 ATP binding site [chemical binding]; other site 684738000958 Q-loop/lid; other site 684738000959 ABC transporter signature motif; other site 684738000960 Walker B; other site 684738000961 D-loop; other site 684738000962 H-loop/switch region; other site 684738000963 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738000964 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738000965 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 684738000966 Walker A/P-loop; other site 684738000967 ATP binding site [chemical binding]; other site 684738000968 Q-loop/lid; other site 684738000969 ABC transporter signature motif; other site 684738000970 Walker B; other site 684738000971 D-loop; other site 684738000972 H-loop/switch region; other site 684738000973 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 684738000974 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 684738000975 hinge; other site 684738000976 active site 684738000977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 684738000978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738000979 non-specific DNA binding site [nucleotide binding]; other site 684738000980 salt bridge; other site 684738000981 sequence-specific DNA binding site [nucleotide binding]; other site 684738000982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738000983 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 684738000984 Walker A/P-loop; other site 684738000985 ATP binding site [chemical binding]; other site 684738000986 Q-loop/lid; other site 684738000987 ABC transporter signature motif; other site 684738000988 Walker B; other site 684738000989 D-loop; other site 684738000990 H-loop/switch region; other site 684738000991 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 684738000992 BioY family; Region: BioY; pfam02632 684738000993 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 684738000994 putative deacylase active site [active] 684738000995 Predicted membrane protein [Function unknown]; Region: COG3859 684738000996 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 684738000997 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 684738000998 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 684738000999 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 684738001000 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 684738001001 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 684738001002 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 684738001003 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 684738001004 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 684738001005 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 684738001006 Walker A/P-loop; other site 684738001007 ATP binding site [chemical binding]; other site 684738001008 Q-loop/lid; other site 684738001009 ABC transporter signature motif; other site 684738001010 Walker B; other site 684738001011 D-loop; other site 684738001012 H-loop/switch region; other site 684738001013 NIL domain; Region: NIL; pfam09383 684738001014 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 684738001015 hypothetical protein; Provisional; Region: PRK13661 684738001016 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738001017 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 684738001018 Walker A/P-loop; other site 684738001019 ATP binding site [chemical binding]; other site 684738001020 Q-loop/lid; other site 684738001021 ABC transporter signature motif; other site 684738001022 Walker B; other site 684738001023 D-loop; other site 684738001024 H-loop/switch region; other site 684738001025 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 684738001026 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738001027 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 684738001028 Walker A/P-loop; other site 684738001029 ATP binding site [chemical binding]; other site 684738001030 Q-loop/lid; other site 684738001031 ABC transporter signature motif; other site 684738001032 Walker B; other site 684738001033 D-loop; other site 684738001034 H-loop/switch region; other site 684738001035 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 684738001036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738001037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738001038 non-specific DNA binding site [nucleotide binding]; other site 684738001039 salt bridge; other site 684738001040 sequence-specific DNA binding site [nucleotide binding]; other site 684738001041 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 684738001042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 684738001043 Walker A/P-loop; other site 684738001044 ATP binding site [chemical binding]; other site 684738001045 Q-loop/lid; other site 684738001046 ABC transporter signature motif; other site 684738001047 Walker B; other site 684738001048 D-loop; other site 684738001049 H-loop/switch region; other site 684738001050 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 684738001051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738001052 ABC-ATPase subunit interface; other site 684738001053 dimer interface [polypeptide binding]; other site 684738001054 putative PBP binding regions; other site 684738001055 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 684738001056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738001057 ABC-ATPase subunit interface; other site 684738001058 dimer interface [polypeptide binding]; other site 684738001059 putative PBP binding regions; other site 684738001060 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 684738001061 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 684738001062 intersubunit interface [polypeptide binding]; other site 684738001063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738001064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738001065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 684738001066 dimerization interface [polypeptide binding]; other site 684738001067 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 684738001068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001069 putative substrate translocation pore; other site 684738001070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 684738001071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 684738001072 active site 684738001073 catalytic tetrad [active] 684738001074 Predicted transcriptional regulators [Transcription]; Region: COG1733 684738001075 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 684738001076 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 684738001077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 684738001078 putative metal binding site [ion binding]; other site 684738001079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738001080 catalytic core [active] 684738001081 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738001082 peroxiredoxin; Region: AhpC; TIGR03137 684738001083 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 684738001084 dimer interface [polypeptide binding]; other site 684738001085 decamer (pentamer of dimers) interface [polypeptide binding]; other site 684738001086 catalytic triad [active] 684738001087 peroxidatic and resolving cysteines [active] 684738001088 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 684738001089 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 684738001090 catalytic residue [active] 684738001091 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 684738001092 catalytic residues [active] 684738001093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738001094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738001095 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 684738001096 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 684738001097 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 684738001098 recombination protein RecR; Reviewed; Region: recR; PRK00076 684738001099 RecR protein; Region: RecR; pfam02132 684738001100 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 684738001101 putative active site [active] 684738001102 putative metal-binding site [ion binding]; other site 684738001103 tetramer interface [polypeptide binding]; other site 684738001104 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 684738001105 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 684738001106 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 684738001107 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 684738001108 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 684738001109 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738001110 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 684738001111 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 684738001112 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 684738001113 peptide binding site [polypeptide binding]; other site 684738001114 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 684738001115 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 684738001116 peptide binding site [polypeptide binding]; other site 684738001117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 684738001118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738001119 dimer interface [polypeptide binding]; other site 684738001120 conserved gate region; other site 684738001121 putative PBP binding loops; other site 684738001122 ABC-ATPase subunit interface; other site 684738001123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 684738001124 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 684738001125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738001126 dimer interface [polypeptide binding]; other site 684738001127 conserved gate region; other site 684738001128 putative PBP binding loops; other site 684738001129 ABC-ATPase subunit interface; other site 684738001130 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 684738001131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 684738001132 Walker A/P-loop; other site 684738001133 ATP binding site [chemical binding]; other site 684738001134 Q-loop/lid; other site 684738001135 ABC transporter signature motif; other site 684738001136 Walker B; other site 684738001137 D-loop; other site 684738001138 H-loop/switch region; other site 684738001139 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 684738001140 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 684738001141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 684738001142 Walker A/P-loop; other site 684738001143 ATP binding site [chemical binding]; other site 684738001144 Q-loop/lid; other site 684738001145 ABC transporter signature motif; other site 684738001146 Walker B; other site 684738001147 D-loop; other site 684738001148 H-loop/switch region; other site 684738001149 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 684738001150 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 684738001151 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 684738001152 G1 box; other site 684738001153 putative GEF interaction site [polypeptide binding]; other site 684738001154 GTP/Mg2+ binding site [chemical binding]; other site 684738001155 Switch I region; other site 684738001156 G2 box; other site 684738001157 G3 box; other site 684738001158 Switch II region; other site 684738001159 G4 box; other site 684738001160 G5 box; other site 684738001161 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 684738001162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 684738001163 DEAD-like helicases superfamily; Region: DEXDc; smart00487 684738001164 ATP binding site [chemical binding]; other site 684738001165 Mg++ binding site [ion binding]; other site 684738001166 motif III; other site 684738001167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738001168 nucleotide binding region [chemical binding]; other site 684738001169 ATP-binding site [chemical binding]; other site 684738001170 GTPase Era; Reviewed; Region: era; PRK00089 684738001171 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 684738001172 G1 box; other site 684738001173 GTP/Mg2+ binding site [chemical binding]; other site 684738001174 Switch I region; other site 684738001175 G2 box; other site 684738001176 Switch II region; other site 684738001177 G3 box; other site 684738001178 G4 box; other site 684738001179 G5 box; other site 684738001180 KH domain; Region: KH_2; pfam07650 684738001181 asparagine synthetase B; Provisional; Region: asnB; PRK09431 684738001182 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 684738001183 dimer interface [polypeptide binding]; other site 684738001184 active site 684738001185 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 684738001186 Ligand Binding Site [chemical binding]; other site 684738001187 Molecular Tunnel; other site 684738001188 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 684738001189 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 684738001190 DNA binding site [nucleotide binding] 684738001191 catalytic residue [active] 684738001192 H2TH interface [polypeptide binding]; other site 684738001193 putative catalytic residues [active] 684738001194 turnover-facilitating residue; other site 684738001195 intercalation triad [nucleotide binding]; other site 684738001196 8OG recognition residue [nucleotide binding]; other site 684738001197 putative reading head residues; other site 684738001198 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 684738001199 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 684738001200 recombinase A; Provisional; Region: recA; PRK09354 684738001201 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 684738001202 hexamer interface [polypeptide binding]; other site 684738001203 Walker A motif; other site 684738001204 ATP binding site [chemical binding]; other site 684738001205 Walker B motif; other site 684738001206 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 684738001207 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 684738001208 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 684738001209 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 684738001210 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 684738001211 putative active site [active] 684738001212 putative metal binding residues [ion binding]; other site 684738001213 signature motif; other site 684738001214 putative triphosphate binding site [ion binding]; other site 684738001215 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 684738001216 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 684738001217 synthetase active site [active] 684738001218 NTP binding site [chemical binding]; other site 684738001219 metal binding site [ion binding]; metal-binding site 684738001220 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 684738001221 ATP-NAD kinase; Region: NAD_kinase; pfam01513 684738001222 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 684738001223 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 684738001224 active site 684738001225 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 684738001226 active site 684738001227 lysine transporter; Provisional; Region: PRK10836 684738001228 Predicted flavoprotein [General function prediction only]; Region: COG0431 684738001229 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 684738001230 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 684738001231 ApbE family; Region: ApbE; pfam02424 684738001232 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 684738001233 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 684738001234 dimer interface [polypeptide binding]; other site 684738001235 putative anticodon binding site; other site 684738001236 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 684738001237 motif 1; other site 684738001238 active site 684738001239 motif 2; other site 684738001240 motif 3; other site 684738001241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738001242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738001243 LysR substrate binding domain; Region: LysR_substrate; pfam03466 684738001244 dimerization interface [polypeptide binding]; other site 684738001245 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 684738001246 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 684738001247 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 684738001248 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738001249 NAD binding site [chemical binding]; other site 684738001250 dimer interface [polypeptide binding]; other site 684738001251 substrate binding site [chemical binding]; other site 684738001252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738001253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738001254 LysR substrate binding domain; Region: LysR_substrate; pfam03466 684738001255 dimerization interface [polypeptide binding]; other site 684738001256 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 684738001257 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 684738001258 gating phenylalanine in ion channel; other site 684738001259 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 684738001260 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 684738001261 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 684738001262 Ligand Binding Site [chemical binding]; other site 684738001263 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 684738001264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001265 putative substrate translocation pore; other site 684738001266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001267 putative substrate translocation pore; other site 684738001268 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 684738001269 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 684738001270 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 684738001271 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 684738001272 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 684738001273 active site 684738001274 HIGH motif; other site 684738001275 dimer interface [polypeptide binding]; other site 684738001276 KMSKS motif; other site 684738001277 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738001278 RNA binding surface [nucleotide binding]; other site 684738001279 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 684738001280 Transglycosylase; Region: Transgly; pfam00912 684738001281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 684738001282 Glutamyl aminopeptidase, C-terminal fragment; frameshift 684738001283 Glutamyl aminopeptidase, N-terminal fragment; frameshift 684738001284 Predicted small secreted protein [Function unknown]; Region: COG5584 684738001285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 684738001286 catalytic residues [active] 684738001287 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 684738001288 putative tRNA-binding site [nucleotide binding]; other site 684738001289 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 684738001290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738001291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738001292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738001293 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 684738001294 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 684738001295 dimer interface [polypeptide binding]; other site 684738001296 ssDNA binding site [nucleotide binding]; other site 684738001297 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738001298 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 684738001299 oligomerisation interface [polypeptide binding]; other site 684738001300 mobile loop; other site 684738001301 roof hairpin; other site 684738001302 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 684738001303 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 684738001304 ring oligomerisation interface [polypeptide binding]; other site 684738001305 ATP/Mg binding site [chemical binding]; other site 684738001306 stacking interactions; other site 684738001307 hinge regions; other site 684738001308 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 684738001309 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 684738001310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 684738001311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 684738001312 putative active site [active] 684738001313 heme pocket [chemical binding]; other site 684738001314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738001315 dimer interface [polypeptide binding]; other site 684738001316 phosphorylation site [posttranslational modification] 684738001317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738001318 ATP binding site [chemical binding]; other site 684738001319 Mg2+ binding site [ion binding]; other site 684738001320 G-X-G motif; other site 684738001321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738001322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738001323 active site 684738001324 phosphorylation site [posttranslational modification] 684738001325 intermolecular recognition site; other site 684738001326 dimerization interface [polypeptide binding]; other site 684738001327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738001328 DNA binding site [nucleotide binding] 684738001329 thymidylate kinase; Validated; Region: tmk; PRK00698 684738001330 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 684738001331 TMP-binding site; other site 684738001332 ATP-binding site [chemical binding]; other site 684738001333 DNA polymerase III subunit delta'; Validated; Region: PRK07276 684738001334 DNA polymerase III subunit delta'; Validated; Region: PRK08485 684738001335 PSP1 C-terminal conserved region; Region: PSP1; cl00770 684738001336 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 684738001337 Predicted methyltransferases [General function prediction only]; Region: COG0313 684738001338 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 684738001339 putative SAM binding site [chemical binding]; other site 684738001340 putative homodimer interface [polypeptide binding]; other site 684738001341 mevalonate kinase; Region: mevalon_kin; TIGR00549 684738001342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 684738001343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 684738001344 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 684738001345 diphosphomevalonate decarboxylase; Region: PLN02407 684738001346 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 684738001347 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 684738001348 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 684738001349 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 684738001350 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 684738001351 homotetramer interface [polypeptide binding]; other site 684738001352 FMN binding site [chemical binding]; other site 684738001353 homodimer contacts [polypeptide binding]; other site 684738001354 putative active site [active] 684738001355 putative substrate binding site [chemical binding]; other site 684738001356 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 684738001357 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 684738001358 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 684738001359 carbon starvation protein A; Provisional; Region: PRK15015 684738001360 Carbon starvation protein CstA; Region: CstA; pfam02554 684738001361 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 684738001362 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 684738001363 DEAD-like helicases superfamily; Region: DEXDc; smart00487 684738001364 ATP binding site [chemical binding]; other site 684738001365 Mg++ binding site [ion binding]; other site 684738001366 motif III; other site 684738001367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738001368 nucleotide binding region [chemical binding]; other site 684738001369 ATP-binding site [chemical binding]; other site 684738001370 Uncharacterized conserved protein [Function unknown]; Region: COG1434 684738001371 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 684738001372 putative active site [active] 684738001373 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738001374 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738001375 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738001376 putative active site [active] 684738001377 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 684738001378 active site 684738001379 P-loop; other site 684738001380 phosphorylation site [posttranslational modification] 684738001381 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 684738001382 active site 684738001383 methionine cluster; other site 684738001384 phosphorylation site [posttranslational modification] 684738001385 metal binding site [ion binding]; metal-binding site 684738001386 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738001387 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738001388 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738001389 putative active site [active] 684738001390 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 684738001391 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 684738001392 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 684738001393 beta-galactosidase; Region: BGL; TIGR03356 684738001394 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 684738001395 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 684738001396 nucleotide binding pocket [chemical binding]; other site 684738001397 K-X-D-G motif; other site 684738001398 catalytic site [active] 684738001399 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 684738001400 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 684738001401 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 684738001402 Dimer interface [polypeptide binding]; other site 684738001403 BRCT sequence motif; other site 684738001404 putative lipid kinase; Reviewed; Region: PRK13055 684738001405 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 684738001406 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 684738001407 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 684738001408 Walker A/P-loop; other site 684738001409 ATP binding site [chemical binding]; other site 684738001410 Q-loop/lid; other site 684738001411 ABC transporter signature motif; other site 684738001412 Walker B; other site 684738001413 D-loop; other site 684738001414 H-loop/switch region; other site 684738001415 TOBE domain; Region: TOBE_2; pfam08402 684738001416 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 684738001417 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 684738001418 dimer interface [polypeptide binding]; other site 684738001419 PYR/PP interface [polypeptide binding]; other site 684738001420 TPP binding site [chemical binding]; other site 684738001421 substrate binding site [chemical binding]; other site 684738001422 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 684738001423 Domain of unknown function; Region: EKR; smart00890 684738001424 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 684738001425 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 684738001426 TPP-binding site [chemical binding]; other site 684738001427 dimer interface [polypeptide binding]; other site 684738001428 Uncharacterized conserved protein [Function unknown]; Region: COG1624 684738001429 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 684738001430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 684738001431 YbbR-like protein; Region: YbbR; pfam07949 684738001432 YbbR-like protein; Region: YbbR; pfam07949 684738001433 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 684738001434 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 684738001435 active site 684738001436 substrate binding site [chemical binding]; other site 684738001437 metal binding site [ion binding]; metal-binding site 684738001438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738001439 DNA-binding site [nucleotide binding]; DNA binding site 684738001440 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 684738001441 UTRA domain; Region: UTRA; pfam07702 684738001442 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 684738001443 HPr interaction site; other site 684738001444 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738001445 active site 684738001446 phosphorylation site [posttranslational modification] 684738001447 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 684738001448 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738001449 active site turn [active] 684738001450 phosphorylation site [posttranslational modification] 684738001451 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738001452 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 684738001453 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 684738001454 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 684738001455 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 684738001456 beta-phosphoglucomutase; Region: bPGM; TIGR01990 684738001457 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738001458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738001459 motif II; other site 684738001460 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 684738001461 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 684738001462 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 684738001463 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 684738001464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738001465 Coenzyme A binding pocket [chemical binding]; other site 684738001466 Transcriptional regulator [Transcription]; Region: LytR; COG1316 684738001467 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 684738001468 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 684738001469 dimerization interface 3.5A [polypeptide binding]; other site 684738001470 active site 684738001471 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 684738001472 dimer interface [polypeptide binding]; other site 684738001473 substrate binding site [chemical binding]; other site 684738001474 ATP binding site [chemical binding]; other site 684738001475 Predicted membrane protein [Function unknown]; Region: COG4720 684738001476 hypothetical protein; Provisional; Region: PRK13690 684738001477 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 684738001478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 684738001479 catalytic residue [active] 684738001480 CTP synthetase; Validated; Region: pyrG; PRK05380 684738001481 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 684738001482 Catalytic site [active] 684738001483 active site 684738001484 UTP binding site [chemical binding]; other site 684738001485 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 684738001486 active site 684738001487 putative oxyanion hole; other site 684738001488 catalytic triad [active] 684738001489 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 684738001490 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 684738001491 NAD(P) binding site [chemical binding]; other site 684738001492 LDH/MDH dimer interface [polypeptide binding]; other site 684738001493 substrate binding site [chemical binding]; other site 684738001494 Predicted membrane protein [Function unknown]; Region: COG4420 684738001495 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 684738001496 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 684738001497 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 684738001498 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 684738001499 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 684738001500 Substrate-binding site [chemical binding]; other site 684738001501 Substrate specificity [chemical binding]; other site 684738001502 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 684738001503 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 684738001504 active site 684738001505 PHP Thumb interface [polypeptide binding]; other site 684738001506 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 684738001507 generic binding surface II; other site 684738001508 generic binding surface I; other site 684738001509 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 684738001510 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 684738001511 EDD domain protein, DegV family; Region: DegV; TIGR00762 684738001512 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 684738001513 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 684738001514 active site 684738001515 catalytic triad [active] 684738001516 oxyanion hole [active] 684738001517 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 684738001518 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 684738001519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 684738001520 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 684738001521 IHF dimer interface [polypeptide binding]; other site 684738001522 IHF - DNA interface [nucleotide binding]; other site 684738001523 Acetyltransferase, C-terminal fragment; frameshift 684738001524 Acetyltransferase, N-terminal fragment; frameshift 684738001525 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 684738001526 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 684738001527 DNA binding site [nucleotide binding] 684738001528 active site 684738001529 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 684738001530 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 684738001531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 684738001532 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738001533 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738001534 Walker A/P-loop; other site 684738001535 ATP binding site [chemical binding]; other site 684738001536 Q-loop/lid; other site 684738001537 ABC transporter signature motif; other site 684738001538 Walker B; other site 684738001539 D-loop; other site 684738001540 H-loop/switch region; other site 684738001541 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 684738001542 LytTr DNA-binding domain; Region: LytTR; pfam04397 684738001543 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 684738001544 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 684738001545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 684738001546 catalytic residue [active] 684738001547 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 684738001548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 684738001549 NlpC/P60 family; Region: NLPC_P60; cl17555 684738001550 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 684738001551 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 684738001552 peptide binding site [polypeptide binding]; other site 684738001553 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 684738001554 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 684738001555 dimer interface [polypeptide binding]; other site 684738001556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738001557 catalytic residue [active] 684738001558 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 684738001559 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738001560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738001561 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738001562 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 684738001563 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 684738001564 Transglycosylase; Region: Transgly; pfam00912 684738001565 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 684738001566 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 684738001567 hypothetical protein; Provisional; Region: PRK13660 684738001568 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 684738001569 ArsC family; Region: ArsC; pfam03960 684738001570 putative catalytic residues [active] 684738001571 thiol/disulfide switch; other site 684738001572 hypothetical protein; Provisional; Region: PRK04387 684738001573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 684738001574 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 684738001575 active site 684738001576 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 684738001577 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 684738001578 hinge; other site 684738001579 active site 684738001580 trigger factor; Provisional; Region: tig; PRK01490 684738001581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 684738001582 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 684738001583 DNA primase, catalytic core; Region: dnaG; TIGR01391 684738001584 CHC2 zinc finger; Region: zf-CHC2; pfam01807 684738001585 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 684738001586 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 684738001587 active site 684738001588 metal binding site [ion binding]; metal-binding site 684738001589 interdomain interaction site; other site 684738001590 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 684738001591 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 684738001592 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 684738001593 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 684738001594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 684738001595 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 684738001596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 684738001597 DNA binding residues [nucleotide binding] 684738001598 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738001599 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738001600 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738001601 putative active site [active] 684738001602 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 684738001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001604 putative substrate translocation pore; other site 684738001605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738001607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 684738001608 Walker A motif; other site 684738001609 ATP binding site [chemical binding]; other site 684738001610 Walker B motif; other site 684738001611 arginine finger; other site 684738001612 UvrB/uvrC motif; Region: UVR; pfam02151 684738001613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738001614 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 684738001615 Walker A motif; other site 684738001616 ATP binding site [chemical binding]; other site 684738001617 Walker B motif; other site 684738001618 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 684738001619 Predicted transcriptional regulator [Transcription]; Region: COG1959 684738001620 Transcriptional regulator; Region: Rrf2; pfam02082 684738001621 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 684738001622 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 684738001623 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 684738001624 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 684738001625 active site 684738001626 catalytic residues [active] 684738001627 metal binding site [ion binding]; metal-binding site 684738001628 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 684738001629 putative active site [active] 684738001630 Ap4A binding site [chemical binding]; other site 684738001631 nudix motif; other site 684738001632 putative metal binding site [ion binding]; other site 684738001633 excinuclease ABC subunit B; Provisional; Region: PRK05298 684738001634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738001635 ATP binding site [chemical binding]; other site 684738001636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738001637 nucleotide binding region [chemical binding]; other site 684738001638 ATP-binding site [chemical binding]; other site 684738001639 Ultra-violet resistance protein B; Region: UvrB; pfam12344 684738001640 UvrB/uvrC motif; Region: UVR; pfam02151 684738001641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 684738001642 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 684738001643 substrate binding pocket [chemical binding]; other site 684738001644 membrane-bound complex binding site; other site 684738001645 hinge residues; other site 684738001646 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 684738001647 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 684738001648 metal binding site [ion binding]; metal-binding site 684738001649 dimer interface [polypeptide binding]; other site 684738001650 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 684738001651 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 684738001652 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 684738001653 NAD binding site [chemical binding]; other site 684738001654 homotetramer interface [polypeptide binding]; other site 684738001655 homodimer interface [polypeptide binding]; other site 684738001656 substrate binding site [chemical binding]; other site 684738001657 active site 684738001658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738001659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738001660 Walker A/P-loop; other site 684738001661 ATP binding site [chemical binding]; other site 684738001662 Q-loop/lid; other site 684738001663 ABC transporter signature motif; other site 684738001664 Walker B; other site 684738001665 D-loop; other site 684738001666 H-loop/switch region; other site 684738001667 OxaA-like protein precursor; Provisional; Region: PRK02463 684738001668 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 684738001669 Eukaryotic phosphomannomutase; Region: PMM; cl17107 684738001670 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 684738001671 Predicted membrane protein [Function unknown]; Region: COG4684 684738001672 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 684738001673 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 684738001674 Flavoprotein; Region: Flavoprotein; pfam02441 684738001675 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 684738001676 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 684738001677 active site 1 [active] 684738001678 dimer interface [polypeptide binding]; other site 684738001679 hexamer interface [polypeptide binding]; other site 684738001680 active site 2 [active] 684738001681 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 684738001682 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738001683 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 684738001684 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738001685 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 684738001686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738001687 Coenzyme A binding pocket [chemical binding]; other site 684738001688 Uncharacterized conserved protein [Function unknown]; Region: COG1434 684738001689 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 684738001690 putative active site [active] 684738001691 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 684738001692 Predicted membrane protein [Function unknown]; Region: COG4852 684738001693 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 684738001694 DAK2 domain; Region: Dak2; pfam02734 684738001695 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 684738001696 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 684738001697 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 684738001698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 684738001699 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 684738001700 active site 684738001701 Uncharacterized conserved protein [Function unknown]; Region: COG1359 684738001702 Uncharacterized conserved protein [Function unknown]; Region: COG2013 684738001703 DNA polymerase IV; Reviewed; Region: PRK03103 684738001704 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 684738001705 active site 684738001706 DNA binding site [nucleotide binding] 684738001707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738001708 Coenzyme A binding pocket [chemical binding]; other site 684738001709 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738001710 MarR family; Region: MarR; pfam01047 684738001711 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 684738001712 thymidine kinase; Provisional; Region: PRK04296 684738001713 peptide chain release factor 1; Validated; Region: prfA; PRK00591 684738001714 This domain is found in peptide chain release factors; Region: PCRF; smart00937 684738001715 RF-1 domain; Region: RF-1; pfam00472 684738001716 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 684738001717 dimer interface [polypeptide binding]; other site 684738001718 FMN binding site [chemical binding]; other site 684738001719 NADPH bind site [chemical binding]; other site 684738001720 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 684738001721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738001722 S-adenosylmethionine binding site [chemical binding]; other site 684738001723 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 684738001724 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 684738001725 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 684738001726 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 684738001727 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 684738001728 dimer interface [polypeptide binding]; other site 684738001729 active site 684738001730 glycine-pyridoxal phosphate binding site [chemical binding]; other site 684738001731 folate binding site [chemical binding]; other site 684738001732 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 684738001733 Lysozyme-like; Region: Lysozyme_like; pfam13702 684738001734 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 684738001735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 684738001736 catalytic residue [active] 684738001737 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 684738001738 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 684738001739 putative ligand binding site [chemical binding]; other site 684738001740 putative NAD binding site [chemical binding]; other site 684738001741 putative catalytic site [active] 684738001742 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 684738001743 L-serine binding site [chemical binding]; other site 684738001744 ACT domain interface; other site 684738001745 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 684738001746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738001747 motif II; other site 684738001748 acylphosphatase; Provisional; Region: PRK14434 684738001749 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 684738001750 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 684738001751 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 684738001752 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 684738001753 dimer interface [polypeptide binding]; other site 684738001754 flavodoxin; Validated; Region: PRK07308 684738001755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738001757 putative substrate translocation pore; other site 684738001758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738001759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738001760 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 684738001761 active site 684738001762 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 684738001763 Predicted membrane protein [Function unknown]; Region: COG2246 684738001764 GtrA-like protein; Region: GtrA; pfam04138 684738001765 Tim44-like domain; Region: Tim44; cl09208 684738001766 Predicted membrane protein [Function unknown]; Region: COG3326 684738001767 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 684738001768 HPr kinase/phosphorylase; Provisional; Region: PRK05428 684738001769 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 684738001770 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 684738001771 Hpr binding site; other site 684738001772 active site 684738001773 homohexamer subunit interaction site [polypeptide binding]; other site 684738001774 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 684738001775 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 684738001776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 684738001777 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 684738001778 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 684738001779 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 684738001780 Methyltransferase domain; Region: Methyltransf_26; pfam13659 684738001781 DEAD-like helicases superfamily; Region: DEXDc; smart00487 684738001782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738001783 ATP binding site [chemical binding]; other site 684738001784 putative Mg++ binding site [ion binding]; other site 684738001785 Hypothetical protein, YeeC family, N-terminal fragment; frameshift 684738001786 Hypothetical protein, YeeC family, C-terminal fragment; frameshift 684738001787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738001788 non-specific DNA binding site [nucleotide binding]; other site 684738001789 sequence-specific DNA binding site [nucleotide binding]; other site 684738001790 salt bridge; other site 684738001791 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 684738001792 Replication initiation factor; Region: Rep_trans; pfam02486 684738001793 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 684738001794 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738001795 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 684738001796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738001797 active site 684738001798 DNA binding site [nucleotide binding] 684738001799 Int/Topo IB signature motif; other site 684738001800 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 684738001801 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 684738001802 Uncharacterized conserved protein [Function unknown]; Region: COG1284 684738001803 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 684738001804 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 684738001805 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 684738001806 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 684738001807 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 684738001808 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 684738001809 ribonuclease Z; Region: RNase_Z; TIGR02651 684738001810 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 684738001811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738001812 NAD(P) binding site [chemical binding]; other site 684738001813 active site 684738001814 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 684738001815 DHH family; Region: DHH; pfam01368 684738001816 DHHA1 domain; Region: DHHA1; pfam02272 684738001817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 684738001818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738001819 active site 684738001820 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 684738001821 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 684738001822 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 684738001823 dimerization interface [polypeptide binding]; other site 684738001824 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 684738001825 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 684738001826 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 684738001827 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 684738001828 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 684738001829 Clp amino terminal domain; Region: Clp_N; pfam02861 684738001830 Clp amino terminal domain; Region: Clp_N; pfam02861 684738001831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738001832 Walker A motif; other site 684738001833 ATP binding site [chemical binding]; other site 684738001834 Walker B motif; other site 684738001835 arginine finger; other site 684738001836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738001837 Walker A motif; other site 684738001838 ATP binding site [chemical binding]; other site 684738001839 Walker B motif; other site 684738001840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 684738001841 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 684738001842 30S subunit binding site; other site 684738001843 enolase; Provisional; Region: eno; PRK00077 684738001844 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 684738001845 dimer interface [polypeptide binding]; other site 684738001846 metal binding site [ion binding]; metal-binding site 684738001847 substrate binding pocket [chemical binding]; other site 684738001848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738001849 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738001850 Walker A/P-loop; other site 684738001851 ATP binding site [chemical binding]; other site 684738001852 Q-loop/lid; other site 684738001853 ABC transporter signature motif; other site 684738001854 Walker B; other site 684738001855 D-loop; other site 684738001856 H-loop/switch region; other site 684738001857 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 684738001858 FtsX-like permease family; Region: FtsX; pfam02687 684738001859 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 684738001860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738001861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738001862 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 684738001863 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 684738001864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 684738001865 acyl-activating enzyme (AAE) consensus motif; other site 684738001866 acyl-activating enzyme (AAE) consensus motif; other site 684738001867 AMP binding site [chemical binding]; other site 684738001868 active site 684738001869 CoA binding site [chemical binding]; other site 684738001870 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 684738001871 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 684738001872 Cl binding site [ion binding]; other site 684738001873 oligomer interface [polypeptide binding]; other site 684738001874 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 684738001875 Pyruvate formate lyase 1; Region: PFL1; cd01678 684738001876 coenzyme A binding site [chemical binding]; other site 684738001877 active site 684738001878 catalytic residues [active] 684738001879 glycine loop; other site 684738001880 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 684738001881 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 684738001882 CoA-binding site [chemical binding]; other site 684738001883 ATP-binding [chemical binding]; other site 684738001884 drug efflux system protein MdtG; Provisional; Region: PRK09874 684738001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001886 putative substrate translocation pore; other site 684738001887 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 684738001888 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 684738001889 Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038 684738001890 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 684738001891 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 684738001892 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 684738001893 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 684738001894 active site 684738001895 catalytic residues [active] 684738001896 metal binding site [ion binding]; metal-binding site 684738001897 homodimer binding site [polypeptide binding]; other site 684738001898 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 684738001899 carboxyltransferase (CT) interaction site; other site 684738001900 biotinylation site [posttranslational modification]; other site 684738001901 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 684738001902 dimer interface [polypeptide binding]; other site 684738001903 Citrate synthase; Region: Citrate_synt; pfam00285 684738001904 active site 684738001905 citrylCoA binding site [chemical binding]; other site 684738001906 oxalacetate/citrate binding site [chemical binding]; other site 684738001907 coenzyme A binding site [chemical binding]; other site 684738001908 catalytic triad [active] 684738001909 aconitate hydratase; Validated; Region: PRK09277 684738001910 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 684738001911 substrate binding site [chemical binding]; other site 684738001912 ligand binding site [chemical binding]; other site 684738001913 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 684738001914 substrate binding site [chemical binding]; other site 684738001915 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 684738001916 isocitrate dehydrogenase; Validated; Region: PRK07362 684738001917 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 684738001918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 684738001919 oligomer interface [polypeptide binding]; other site 684738001920 active site residues [active] 684738001921 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 684738001922 ArsC family; Region: ArsC; pfam03960 684738001923 putative catalytic residues [active] 684738001924 thiol/disulfide switch; other site 684738001925 Protein of unknown function (DUF998); Region: DUF998; pfam06197 684738001926 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 684738001927 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 684738001928 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738001929 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 684738001930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738001931 motif II; other site 684738001932 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 684738001933 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 684738001934 Predicted acetyltransferase [General function prediction only]; Region: COG2388 684738001935 Uncharacterized conserved protein [Function unknown]; Region: COG3592 684738001936 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 684738001937 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 684738001938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 684738001939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 684738001940 metal binding site [ion binding]; metal-binding site 684738001941 active site 684738001942 I-site; other site 684738001943 Cellulose synthase catalytic subunit (UDP-forming), N-terminal fragment; frameshift 684738001944 Cellulose synthase catalytic subunit (UDP-forming), C-terminal fragment; frameshift 684738001945 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738001946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738001947 DNA binding site [nucleotide binding] 684738001948 domain linker motif; other site 684738001949 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 684738001950 dimerization interface [polypeptide binding]; other site 684738001951 ligand binding site [chemical binding]; other site 684738001952 sodium binding site [ion binding]; other site 684738001953 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 684738001954 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 684738001955 substrate binding [chemical binding]; other site 684738001956 active site 684738001957 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 684738001958 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 684738001959 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738001960 active site turn [active] 684738001961 phosphorylation site [posttranslational modification] 684738001962 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738001963 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 684738001964 HPr interaction site; other site 684738001965 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738001966 active site 684738001967 phosphorylation site [posttranslational modification] 684738001968 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 684738001969 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738001970 nucleotide binding site [chemical binding]; other site 684738001971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738001972 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738001973 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738001974 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738001975 putative active site [active] 684738001976 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 684738001977 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738001978 active site 684738001979 dimer interface [polypeptide binding]; other site 684738001980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 684738001981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 684738001982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738001983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738001984 non-specific DNA binding site [nucleotide binding]; other site 684738001985 salt bridge; other site 684738001986 sequence-specific DNA binding site [nucleotide binding]; other site 684738001987 transcriptional antiterminator BglG; Provisional; Region: PRK09772 684738001988 CAT RNA binding domain; Region: CAT_RBD; smart01061 684738001989 PRD domain; Region: PRD; pfam00874 684738001990 PRD domain; Region: PRD; pfam00874 684738001991 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 684738001992 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738001993 active site turn [active] 684738001994 phosphorylation site [posttranslational modification] 684738001995 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738001996 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 684738001997 HPr interaction site; other site 684738001998 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738001999 active site 684738002000 phosphorylation site [posttranslational modification] 684738002001 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738002002 beta-galactosidase; Region: BGL; TIGR03356 684738002003 CAT RNA binding domain; Region: CAT_RBD; smart01061 684738002004 transcriptional antiterminator BglG; Provisional; Region: PRK09772 684738002005 PRD domain; Region: PRD; pfam00874 684738002006 PRD domain; Region: PRD; pfam00874 684738002007 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 684738002008 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738002009 active site turn [active] 684738002010 phosphorylation site [posttranslational modification] 684738002011 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738002012 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 684738002013 HPr interaction site; other site 684738002014 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738002015 active site 684738002016 phosphorylation site [posttranslational modification] 684738002017 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738002018 beta-galactosidase; Region: BGL; TIGR03356 684738002019 putative transposase OrfB; Reviewed; Region: PHA02517 684738002020 HTH-like domain; Region: HTH_21; pfam13276 684738002021 Integrase core domain; Region: rve; pfam00665 684738002022 Integrase core domain; Region: rve_3; pfam13683 684738002023 Transposase; Region: HTH_Tnp_1; pfam01527 684738002024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738002025 CHAP domain; Region: CHAP; pfam05257 684738002026 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 684738002027 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 684738002028 Clostridial hydrophobic W; Region: ChW; pfam07538 684738002029 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 684738002030 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 684738002031 multiple promoter invertase; Provisional; Region: mpi; PRK13413 684738002032 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 684738002033 catalytic residues [active] 684738002034 catalytic nucleophile [active] 684738002035 Presynaptic Site I dimer interface [polypeptide binding]; other site 684738002036 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 684738002037 Synaptic Flat tetramer interface [polypeptide binding]; other site 684738002038 Synaptic Site I dimer interface [polypeptide binding]; other site 684738002039 DNA binding site [nucleotide binding] 684738002040 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 684738002041 DNA-binding interface [nucleotide binding]; DNA binding site 684738002042 Type I site-specific deoxyribonuclease, restriction subunit, HsdR family, N-terminal fragment 684738002043 Type I site-specific deoxyribonuclease, specificity subunit, HsdS family, C-terminal fragment 684738002044 Integral membrane protein DUF95; Region: DUF95; pfam01944 684738002045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738002046 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 684738002047 active site 684738002048 DNA binding site [nucleotide binding] 684738002049 Int/Topo IB signature motif; other site 684738002050 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 684738002051 Divergent AAA domain; Region: AAA_4; pfam04326 684738002052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738002053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738002054 non-specific DNA binding site [nucleotide binding]; other site 684738002055 salt bridge; other site 684738002056 sequence-specific DNA binding site [nucleotide binding]; other site 684738002057 putative transposase OrfB; Reviewed; Region: PHA02517 684738002058 HTH-like domain; Region: HTH_21; pfam13276 684738002059 Integrase core domain; Region: rve; pfam00665 684738002060 Integrase core domain; Region: rve_3; pfam13683 684738002061 Transposase; Region: HTH_Tnp_1; pfam01527 684738002062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738002063 Integrase, N-terminal fragment; 2 stop codons 684738002064 Integrase, C-terminal fragment; 2 stop codons 684738002065 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 684738002066 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 684738002067 active site 684738002068 topology modulation protein; Reviewed; Region: PRK08118 684738002069 AAA domain; Region: AAA_17; pfam13207 684738002070 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 684738002071 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 684738002072 putative active site [active] 684738002073 putative metal binding site [ion binding]; other site 684738002074 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 684738002075 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 684738002076 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 684738002077 S-adenosylmethionine binding site [chemical binding]; other site 684738002078 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 684738002079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 684738002080 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 684738002081 active site 684738002082 elongation factor P; Validated; Region: PRK00529 684738002083 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 684738002084 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 684738002085 RNA binding site [nucleotide binding]; other site 684738002086 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 684738002087 RNA binding site [nucleotide binding]; other site 684738002088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 684738002089 Transcription termination factor [Transcription]; Region: NusB; COG0781 684738002090 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 684738002091 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 684738002092 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 684738002093 ligand binding site; other site 684738002094 oligomer interface; other site 684738002095 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 684738002096 dimer interface [polypeptide binding]; other site 684738002097 N-terminal domain interface [polypeptide binding]; other site 684738002098 sulfate 1 binding site; other site 684738002099 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 684738002100 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 684738002101 ligand binding site; other site 684738002102 oligomer interface; other site 684738002103 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 684738002104 dimer interface [polypeptide binding]; other site 684738002105 N-terminal domain interface [polypeptide binding]; other site 684738002106 sulfate 1 binding site; other site 684738002107 glycogen synthase; Provisional; Region: glgA; PRK00654 684738002108 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 684738002109 ADP-binding pocket [chemical binding]; other site 684738002110 homodimer interface [polypeptide binding]; other site 684738002111 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 684738002112 homodimer interface [polypeptide binding]; other site 684738002113 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 684738002114 active site pocket [active] 684738002115 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 684738002116 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 684738002117 active site 684738002118 homodimer interface [polypeptide binding]; other site 684738002119 catalytic site [active] 684738002120 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 684738002121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738002122 putative substrate translocation pore; other site 684738002123 POT family; Region: PTR2; pfam00854 684738002124 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 684738002125 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 684738002126 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 684738002127 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 684738002128 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738002129 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 684738002130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738002131 Walker A/P-loop; other site 684738002132 ATP binding site [chemical binding]; other site 684738002133 Q-loop/lid; other site 684738002134 ABC transporter signature motif; other site 684738002135 Walker B; other site 684738002136 D-loop; other site 684738002137 H-loop/switch region; other site 684738002138 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 684738002139 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 684738002140 Walker A/P-loop; other site 684738002141 ATP binding site [chemical binding]; other site 684738002142 Q-loop/lid; other site 684738002143 ABC transporter signature motif; other site 684738002144 Walker B; other site 684738002145 D-loop; other site 684738002146 H-loop/switch region; other site 684738002147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738002148 putative Zn2+ binding site [ion binding]; other site 684738002149 putative DNA binding site [nucleotide binding]; other site 684738002150 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 684738002151 Flavodoxin domain; Region: Flavodoxin_5; cl17428 684738002152 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 684738002153 active site 684738002154 catalytic triad [active] 684738002155 oxyanion hole [active] 684738002156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738002157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738002158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738002159 Walker A/P-loop; other site 684738002160 ATP binding site [chemical binding]; other site 684738002161 Q-loop/lid; other site 684738002162 ABC transporter signature motif; other site 684738002163 Walker B; other site 684738002164 D-loop; other site 684738002165 H-loop/switch region; other site 684738002166 Predicted integral membrane protein [Function unknown]; Region: COG3548 684738002167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 684738002168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 684738002169 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738002170 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738002171 Walker A/P-loop; other site 684738002172 ATP binding site [chemical binding]; other site 684738002173 Q-loop/lid; other site 684738002174 ABC transporter signature motif; other site 684738002175 Walker B; other site 684738002176 D-loop; other site 684738002177 H-loop/switch region; other site 684738002178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 684738002179 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 684738002180 FtsX-like permease family; Region: FtsX; pfam02687 684738002181 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 684738002182 Predicted membrane protein [Function unknown]; Region: COG3619 684738002183 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 684738002184 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 684738002185 putative NAD(P) binding site [chemical binding]; other site 684738002186 dimer interface [polypeptide binding]; other site 684738002187 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 684738002188 substrate binding site [chemical binding]; other site 684738002189 THF binding site; other site 684738002190 zinc-binding site [ion binding]; other site 684738002191 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 684738002192 Serine/threonine protein metallophosphatase, N-terminal fragment; frameshift 684738002193 Serine/threonine protein metallophosphatase, C-terminal fragment; frameshift 684738002194 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 684738002195 nucleoside/Zn binding site; other site 684738002196 dimer interface [polypeptide binding]; other site 684738002197 catalytic motif [active] 684738002198 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 684738002199 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738002200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738002201 non-specific DNA binding site [nucleotide binding]; other site 684738002202 salt bridge; other site 684738002203 sequence-specific DNA binding site [nucleotide binding]; other site 684738002204 Hypothetical protein, N-terminal fragment; stop codon 684738002205 Hypothetical protein, C-terminal fragment; stop codon 684738002206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 684738002207 CoenzymeA binding site [chemical binding]; other site 684738002208 subunit interaction site [polypeptide binding]; other site 684738002209 PHB binding site; other site 684738002210 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 684738002211 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 684738002212 active site 684738002213 octamer interface [polypeptide binding]; other site 684738002214 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 684738002215 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 684738002216 acyl-activating enzyme (AAE) consensus motif; other site 684738002217 putative AMP binding site [chemical binding]; other site 684738002218 putative active site [active] 684738002219 putative CoA binding site [chemical binding]; other site 684738002220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 684738002221 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 684738002222 substrate binding site [chemical binding]; other site 684738002223 oxyanion hole (OAH) forming residues; other site 684738002224 trimer interface [polypeptide binding]; other site 684738002225 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 684738002226 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 684738002227 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 684738002228 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 684738002229 dimer interface [polypeptide binding]; other site 684738002230 tetramer interface [polypeptide binding]; other site 684738002231 PYR/PP interface [polypeptide binding]; other site 684738002232 TPP binding site [chemical binding]; other site 684738002233 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 684738002234 TPP-binding site; other site 684738002235 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 684738002236 isochorismate synthases; Region: isochor_syn; TIGR00543 684738002237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 684738002238 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 684738002239 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 684738002240 DRTGG domain; Region: DRTGG; pfam07085 684738002241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 684738002242 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 684738002243 DHH family; Region: DHH; pfam01368 684738002244 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 684738002245 active site 684738002246 homotetramer interface [polypeptide binding]; other site 684738002247 homodimer interface [polypeptide binding]; other site 684738002248 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 684738002249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738002250 active site 684738002251 motif I; other site 684738002252 motif II; other site 684738002253 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738002254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 684738002255 metal binding site [ion binding]; metal-binding site 684738002256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 684738002257 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 684738002258 aspartate kinase; Reviewed; Region: PRK09034 684738002259 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 684738002260 nucleotide binding site [chemical binding]; other site 684738002261 substrate binding site [chemical binding]; other site 684738002262 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 684738002263 allosteric regulatory residue; other site 684738002264 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 684738002265 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 684738002266 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 684738002267 active site 684738002268 nucleophile elbow; other site 684738002269 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738002270 MarR family; Region: MarR_2; pfam12802 684738002271 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 684738002272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738002273 motif II; other site 684738002274 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 684738002275 DHH family; Region: DHH; pfam01368 684738002276 DHHA1 domain; Region: DHHA1; pfam02272 684738002277 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 684738002278 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 684738002279 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 684738002280 replicative DNA helicase; Provisional; Region: PRK05748 684738002281 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 684738002282 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 684738002283 Walker A motif; other site 684738002284 ATP binding site [chemical binding]; other site 684738002285 Walker B motif; other site 684738002286 DNA binding loops [nucleotide binding] 684738002287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 684738002288 Phosphotransferase enzyme family; Region: APH; pfam01636 684738002289 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 684738002290 active site 684738002291 ATP binding site [chemical binding]; other site 684738002292 substrate binding site [chemical binding]; other site 684738002293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738002294 S-adenosylmethionine binding site [chemical binding]; other site 684738002295 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 684738002296 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 684738002297 ATP cone domain; Region: ATP-cone; pfam03477 684738002298 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 684738002299 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 684738002300 primosomal protein DnaI; Reviewed; Region: PRK08939 684738002301 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 684738002302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738002303 Walker A motif; other site 684738002304 ATP binding site [chemical binding]; other site 684738002305 Walker B motif; other site 684738002306 arginine finger; other site 684738002307 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 684738002308 dimer interface [polypeptide binding]; other site 684738002309 FMN binding site [chemical binding]; other site 684738002310 NADPH bind site [chemical binding]; other site 684738002311 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 684738002312 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 684738002313 GTP-binding protein Der; Reviewed; Region: PRK00093 684738002314 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 684738002315 G1 box; other site 684738002316 GTP/Mg2+ binding site [chemical binding]; other site 684738002317 Switch I region; other site 684738002318 G2 box; other site 684738002319 Switch II region; other site 684738002320 G3 box; other site 684738002321 G4 box; other site 684738002322 G5 box; other site 684738002323 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 684738002324 G1 box; other site 684738002325 GTP/Mg2+ binding site [chemical binding]; other site 684738002326 Switch I region; other site 684738002327 G2 box; other site 684738002328 G3 box; other site 684738002329 Switch II region; other site 684738002330 G4 box; other site 684738002331 G5 box; other site 684738002332 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738002333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738002334 non-specific DNA binding site [nucleotide binding]; other site 684738002335 salt bridge; other site 684738002336 sequence-specific DNA binding site [nucleotide binding]; other site 684738002337 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738002338 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 684738002339 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 684738002340 active site 684738002341 catalytic site [active] 684738002342 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 684738002343 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 684738002344 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 684738002345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 684738002346 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 684738002347 putative oligomer interface [polypeptide binding]; other site 684738002348 putative RNA binding site [nucleotide binding]; other site 684738002349 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 684738002350 NusA N-terminal domain; Region: NusA_N; pfam08529 684738002351 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 684738002352 RNA binding site [nucleotide binding]; other site 684738002353 homodimer interface [polypeptide binding]; other site 684738002354 NusA-like KH domain; Region: KH_5; pfam13184 684738002355 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 684738002356 G-X-X-G motif; other site 684738002357 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 684738002358 putative RNA binding cleft [nucleotide binding]; other site 684738002359 hypothetical protein; Provisional; Region: PRK07283 684738002360 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 684738002361 translation initiation factor IF-2; Region: IF-2; TIGR00487 684738002362 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 684738002363 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 684738002364 G1 box; other site 684738002365 putative GEF interaction site [polypeptide binding]; other site 684738002366 GTP/Mg2+ binding site [chemical binding]; other site 684738002367 Switch I region; other site 684738002368 G2 box; other site 684738002369 G3 box; other site 684738002370 Switch II region; other site 684738002371 G4 box; other site 684738002372 G5 box; other site 684738002373 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 684738002374 Translation-initiation factor 2; Region: IF-2; pfam11987 684738002375 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 684738002376 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 684738002377 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 684738002378 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 684738002379 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738002380 MarR family; Region: MarR; pfam01047 684738002381 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 684738002382 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 684738002383 dimer interface [polypeptide binding]; other site 684738002384 active site 684738002385 CoA binding pocket [chemical binding]; other site 684738002386 acyl carrier protein; Provisional; Region: acpP; PRK00982 684738002387 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 684738002388 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 684738002389 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 684738002390 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 684738002391 NAD(P) binding site [chemical binding]; other site 684738002392 homotetramer interface [polypeptide binding]; other site 684738002393 homodimer interface [polypeptide binding]; other site 684738002394 active site 684738002395 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 684738002396 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 684738002397 dimer interface [polypeptide binding]; other site 684738002398 active site 684738002399 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 684738002400 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 684738002401 carboxyltransferase (CT) interaction site; other site 684738002402 biotinylation site [posttranslational modification]; other site 684738002403 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 684738002404 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 684738002405 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 684738002406 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 684738002407 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 684738002408 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 684738002409 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 684738002410 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 684738002411 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 684738002412 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 684738002413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 684738002414 homodimer interface [polypeptide binding]; other site 684738002415 substrate-cofactor binding pocket; other site 684738002416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738002417 catalytic residue [active] 684738002418 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 684738002419 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 684738002420 dimer interface [polypeptide binding]; other site 684738002421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738002422 catalytic residue [active] 684738002423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 684738002424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 684738002425 active site residue [active] 684738002426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 684738002427 active site residue [active] 684738002428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738002429 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 684738002430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738002431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738002432 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 684738002433 active site residue [active] 684738002434 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 684738002435 putative homodimer interface [polypeptide binding]; other site 684738002436 putative homotetramer interface [polypeptide binding]; other site 684738002437 putative metal binding site [ion binding]; other site 684738002438 putative homodimer-homodimer interface [polypeptide binding]; other site 684738002439 putative allosteric switch controlling residues; other site 684738002440 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 684738002441 ArsC family; Region: ArsC; pfam03960 684738002442 putative ArsC-like catalytic residues; other site 684738002443 putative TRX-like catalytic residues [active] 684738002444 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 684738002445 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 684738002446 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 684738002447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 684738002448 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 684738002449 active site 684738002450 putative catalytic site [active] 684738002451 DNA binding site [nucleotide binding] 684738002452 putative phosphate binding site [ion binding]; other site 684738002453 metal binding site A [ion binding]; metal-binding site 684738002454 AP binding site [nucleotide binding]; other site 684738002455 metal binding site B [ion binding]; metal-binding site 684738002456 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 684738002457 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 684738002458 active site 684738002459 HIGH motif; other site 684738002460 KMSKS motif; other site 684738002461 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 684738002462 tRNA binding surface [nucleotide binding]; other site 684738002463 anticodon binding site; other site 684738002464 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 684738002465 dimer interface [polypeptide binding]; other site 684738002466 putative tRNA-binding site [nucleotide binding]; other site 684738002467 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 684738002468 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 684738002469 classical (c) SDRs; Region: SDR_c; cd05233 684738002470 NAD(P) binding site [chemical binding]; other site 684738002471 active site 684738002472 Predicted membrane protein [Function unknown]; Region: COG4708 684738002473 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 684738002474 NADH(P)-binding; Region: NAD_binding_10; pfam13460 684738002475 NAD binding site [chemical binding]; other site 684738002476 substrate binding site [chemical binding]; other site 684738002477 putative active site [active] 684738002478 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 684738002479 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 684738002480 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 684738002481 heterotetramer interface [polypeptide binding]; other site 684738002482 active site pocket [active] 684738002483 cleavage site 684738002484 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 684738002485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 684738002486 inhibitor-cofactor binding pocket; inhibition site 684738002487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738002488 catalytic residue [active] 684738002489 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 684738002490 feedback inhibition sensing region; other site 684738002491 homohexameric interface [polypeptide binding]; other site 684738002492 nucleotide binding site [chemical binding]; other site 684738002493 N-acetyl-L-glutamate binding site [chemical binding]; other site 684738002494 ornithine carbamoyltransferase; Validated; Region: PRK02102 684738002495 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 684738002496 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 684738002497 ribonuclease III; Reviewed; Region: rnc; PRK00102 684738002498 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 684738002499 dimerization interface [polypeptide binding]; other site 684738002500 active site 684738002501 metal binding site [ion binding]; metal-binding site 684738002502 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 684738002503 dsRNA binding site [nucleotide binding]; other site 684738002504 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 684738002505 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 684738002506 Walker A/P-loop; other site 684738002507 ATP binding site [chemical binding]; other site 684738002508 Q-loop/lid; other site 684738002509 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 684738002510 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 684738002511 ABC transporter signature motif; other site 684738002512 Walker B; other site 684738002513 D-loop; other site 684738002514 H-loop/switch region; other site 684738002515 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 684738002516 Sulfatase; Region: Sulfatase; cl17466 684738002517 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 684738002518 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 684738002519 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 684738002520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738002521 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738002522 active site 684738002523 motif I; other site 684738002524 motif II; other site 684738002525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738002526 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 684738002527 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 684738002528 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 684738002529 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 684738002530 P loop; other site 684738002531 GTP binding site [chemical binding]; other site 684738002532 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 684738002533 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 684738002534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738002535 active site 684738002536 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 684738002537 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 684738002538 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 684738002539 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 684738002540 HIGH motif; other site 684738002541 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 684738002542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738002543 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738002544 active site 684738002545 KMSKS motif; other site 684738002546 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 684738002547 tRNA binding surface [nucleotide binding]; other site 684738002548 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 684738002549 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738002550 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738002551 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738002552 putative active site [active] 684738002553 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 684738002554 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 684738002555 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738002556 beta-galactosidase; Region: BGL; TIGR03356 684738002557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 684738002558 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 684738002559 nucleophilic elbow; other site 684738002560 catalytic triad; other site 684738002561 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 684738002562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 684738002563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738002564 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 684738002565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738002566 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 684738002567 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 684738002568 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 684738002569 putative L-serine binding site [chemical binding]; other site 684738002570 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 684738002571 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 684738002572 Predicted transcriptional regulator [Transcription]; Region: COG3682 684738002573 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 684738002574 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 684738002575 metal-binding site [ion binding] 684738002576 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 684738002577 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 684738002578 metal-binding site [ion binding] 684738002579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738002580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738002581 Predicted membrane protein [Function unknown]; Region: COG4485 684738002582 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 684738002583 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 684738002584 nucleotide binding site/active site [active] 684738002585 HIT family signature motif; other site 684738002586 catalytic residue [active] 684738002587 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 684738002588 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 684738002589 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 684738002590 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 684738002591 RNA binding site [nucleotide binding]; other site 684738002592 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 684738002593 RNA binding site [nucleotide binding]; other site 684738002594 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 684738002595 RNA binding site [nucleotide binding]; other site 684738002596 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 684738002597 RNA binding site [nucleotide binding]; other site 684738002598 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 684738002599 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 684738002600 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 684738002601 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 684738002602 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 684738002603 GIY-YIG motif/motif A; other site 684738002604 active site 684738002605 catalytic site [active] 684738002606 putative DNA binding site [nucleotide binding]; other site 684738002607 metal binding site [ion binding]; metal-binding site 684738002608 UvrB/uvrC motif; Region: UVR; pfam02151 684738002609 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 684738002610 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 684738002611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 684738002612 minor groove reading motif; other site 684738002613 helix-hairpin-helix signature motif; other site 684738002614 substrate binding pocket [chemical binding]; other site 684738002615 active site 684738002616 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 684738002617 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 684738002618 DNA binding and oxoG recognition site [nucleotide binding] 684738002619 dipeptidase PepV; Region: dipeptidase; TIGR01886 684738002620 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 684738002621 active site 684738002622 metal binding site [ion binding]; metal-binding site 684738002623 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 684738002624 alanine racemase; Reviewed; Region: alr; PRK00053 684738002625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 684738002626 active site 684738002627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 684738002628 dimer interface [polypeptide binding]; other site 684738002629 substrate binding site [chemical binding]; other site 684738002630 catalytic residues [active] 684738002631 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 684738002632 ArsC family; Region: ArsC; pfam03960 684738002633 putative catalytic residues [active] 684738002634 thiol/disulfide switch; other site 684738002635 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 684738002636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738002637 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738002638 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 684738002639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738002640 Walker A/P-loop; other site 684738002641 ATP binding site [chemical binding]; other site 684738002642 Q-loop/lid; other site 684738002643 ABC transporter signature motif; other site 684738002644 Walker B; other site 684738002645 D-loop; other site 684738002646 H-loop/switch region; other site 684738002647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738002648 ABC-ATPase subunit interface; other site 684738002649 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 684738002650 putative transposase OrfB; Reviewed; Region: PHA02517 684738002651 HTH-like domain; Region: HTH_21; pfam13276 684738002652 Integrase core domain; Region: rve; pfam00665 684738002653 Integrase core domain; Region: rve_3; pfam13683 684738002654 Transposase; Region: HTH_Tnp_1; pfam01527 684738002655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738002656 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 684738002657 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738002658 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 684738002659 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 684738002660 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 684738002661 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 684738002662 homodimer interface [polypeptide binding]; other site 684738002663 NADP binding site [chemical binding]; other site 684738002664 substrate binding site [chemical binding]; other site 684738002665 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 684738002666 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 684738002667 generic binding surface II; other site 684738002668 generic binding surface I; other site 684738002669 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 684738002670 Glycerate kinase, N-terminal fragment; frameshift 684738002671 Glycerate kinase, C-terminal fragment; frameshift 684738002672 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 684738002673 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 684738002674 substrate binding pocket [chemical binding]; other site 684738002675 chain length determination region; other site 684738002676 substrate-Mg2+ binding site; other site 684738002677 catalytic residues [active] 684738002678 aspartate-rich region 1; other site 684738002679 active site lid residues [active] 684738002680 aspartate-rich region 2; other site 684738002681 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 684738002682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738002683 RNA binding surface [nucleotide binding]; other site 684738002684 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 684738002685 Arginine repressor [Transcription]; Region: ArgR; COG1438 684738002686 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 684738002687 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 684738002688 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 684738002689 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 684738002690 Walker A/P-loop; other site 684738002691 ATP binding site [chemical binding]; other site 684738002692 Q-loop/lid; other site 684738002693 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 684738002694 ABC transporter signature motif; other site 684738002695 Walker B; other site 684738002696 D-loop; other site 684738002697 H-loop/switch region; other site 684738002698 Predicted integral membrane protein [Function unknown]; Region: COG3548 684738002699 Predicted membrane protein [Function unknown]; Region: COG3152 684738002700 Predicted membrane protein [Function unknown]; Region: COG3152 684738002701 Protein of unknown function (DUF805); Region: DUF805; cl01224 684738002702 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 684738002703 MraW methylase family; Region: Methyltransf_5; pfam01795 684738002704 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 684738002705 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 684738002706 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 684738002707 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 684738002708 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 684738002709 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 684738002710 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 684738002711 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 684738002712 Mg++ binding site [ion binding]; other site 684738002713 putative catalytic motif [active] 684738002714 putative substrate binding site [chemical binding]; other site 684738002715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738002716 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738002717 Walker A/P-loop; other site 684738002718 ATP binding site [chemical binding]; other site 684738002719 Q-loop/lid; other site 684738002720 ABC transporter signature motif; other site 684738002721 Walker B; other site 684738002722 D-loop; other site 684738002723 H-loop/switch region; other site 684738002724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738002725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738002726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 684738002727 dimerization interface [polypeptide binding]; other site 684738002728 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 684738002729 synthetase active site [active] 684738002730 NTP binding site [chemical binding]; other site 684738002731 metal binding site [ion binding]; metal-binding site 684738002732 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 684738002733 N-glycosyltransferase; Provisional; Region: PRK11204 684738002734 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 684738002735 DXD motif; other site 684738002736 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 684738002737 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 684738002738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738002739 Ligand Binding Site [chemical binding]; other site 684738002740 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 684738002741 IHF dimer interface [polypeptide binding]; other site 684738002742 IHF - DNA interface [nucleotide binding]; other site 684738002743 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 684738002744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738002745 Predicted membrane protein [Function unknown]; Region: COG1511 684738002746 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 684738002747 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 684738002748 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 684738002749 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 684738002750 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 684738002751 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 684738002752 Walker A/P-loop; other site 684738002753 ATP binding site [chemical binding]; other site 684738002754 Q-loop/lid; other site 684738002755 ABC transporter signature motif; other site 684738002756 Walker B; other site 684738002757 D-loop; other site 684738002758 H-loop/switch region; other site 684738002759 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 684738002760 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 684738002761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738002762 ABC-ATPase subunit interface; other site 684738002763 dimer interface [polypeptide binding]; other site 684738002764 putative PBP binding regions; other site 684738002765 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 684738002766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738002767 ABC-ATPase subunit interface; other site 684738002768 dimer interface [polypeptide binding]; other site 684738002769 putative PBP binding regions; other site 684738002770 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 684738002771 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 684738002772 siderophore binding site; other site 684738002773 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 684738002774 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 684738002775 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 684738002776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 684738002777 Surface antigen [General function prediction only]; Region: COG3942 684738002778 CHAP domain; Region: CHAP; pfam05257 684738002779 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 684738002780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 684738002781 putative metal binding site [ion binding]; other site 684738002782 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 684738002783 Transcriptional regulator [Transcription]; Region: LytR; COG1316 684738002784 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 684738002785 Predicted membrane protein [Function unknown]; Region: COG4758 684738002786 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 684738002787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738002788 Histidine kinase; Region: HisKA_3; pfam07730 684738002789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738002790 ATP binding site [chemical binding]; other site 684738002791 Mg2+ binding site [ion binding]; other site 684738002792 G-X-G motif; other site 684738002793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 684738002794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738002795 active site 684738002796 phosphorylation site [posttranslational modification] 684738002797 intermolecular recognition site; other site 684738002798 dimerization interface [polypeptide binding]; other site 684738002799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 684738002800 DNA binding residues [nucleotide binding] 684738002801 dimerization interface [polypeptide binding]; other site 684738002802 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738002803 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738002804 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 684738002805 active site 684738002806 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 684738002807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 684738002808 RNA binding site [nucleotide binding]; other site 684738002809 Uncharacterized conserved protein [Function unknown]; Region: COG0398 684738002810 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 684738002811 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 684738002812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 684738002813 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 684738002814 putative NAD(P) binding site [chemical binding]; other site 684738002815 catalytic Zn binding site [ion binding]; other site 684738002816 acetoin reductase; Validated; Region: PRK08643 684738002817 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 684738002818 NAD binding site [chemical binding]; other site 684738002819 homotetramer interface [polypeptide binding]; other site 684738002820 homodimer interface [polypeptide binding]; other site 684738002821 active site 684738002822 substrate binding site [chemical binding]; other site 684738002823 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 684738002824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738002825 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738002826 ABC transporter; Region: ABC_tran_2; pfam12848 684738002827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738002828 malate dehydrogenase; Provisional; Region: PRK13529 684738002829 Malic enzyme, N-terminal domain; Region: malic; pfam00390 684738002830 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 684738002831 NAD(P) binding site [chemical binding]; other site 684738002832 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 684738002833 EamA-like transporter family; Region: EamA; pfam00892 684738002834 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 684738002835 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 684738002836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738002837 motif II; other site 684738002838 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 684738002839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738002840 Mg2+ binding site [ion binding]; other site 684738002841 G-X-G motif; other site 684738002842 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 684738002843 anchoring element; other site 684738002844 dimer interface [polypeptide binding]; other site 684738002845 ATP binding site [chemical binding]; other site 684738002846 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 684738002847 active site 684738002848 putative metal-binding site [ion binding]; other site 684738002849 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 684738002850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738002851 S-adenosylmethionine binding site [chemical binding]; other site 684738002852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738002853 MarR family; Region: MarR_2; pfam12802 684738002854 MarR family; Region: MarR_2; cl17246 684738002855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738002856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738002857 putative substrate translocation pore; other site 684738002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738002859 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 684738002860 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 684738002861 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 684738002862 Walker A/P-loop; other site 684738002863 ATP binding site [chemical binding]; other site 684738002864 Q-loop/lid; other site 684738002865 ABC transporter signature motif; other site 684738002866 Walker B; other site 684738002867 D-loop; other site 684738002868 H-loop/switch region; other site 684738002869 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 684738002870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738002871 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 684738002872 ABC-2 type transporter; Region: ABC2_membrane; cl17235 684738002873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738002874 active site 684738002875 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738002876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738002877 active site 684738002878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738002879 active site 684738002880 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 684738002881 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 684738002882 Protein of unknown function (DUF563); Region: DUF563; pfam04577 684738002883 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 684738002884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 684738002885 UDP-galactopyranose mutase; Region: GLF; pfam03275 684738002886 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 684738002887 active site 684738002888 catalytic triad [active] 684738002889 oxyanion hole [active] 684738002890 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 684738002891 putative substrate binding site [chemical binding]; other site 684738002892 active site 684738002893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738002894 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 684738002895 active site 684738002896 nucleotide binding site [chemical binding]; other site 684738002897 HIGH motif; other site 684738002898 KMSKS motif; other site 684738002899 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 684738002900 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 684738002901 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 684738002902 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 684738002903 Transcriptional regulator [Transcription]; Region: LytR; COG1316 684738002904 phosphopentomutase; Provisional; Region: PRK05362 684738002905 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 684738002906 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 684738002907 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 684738002908 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 684738002909 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 684738002910 hypothetical protein; Provisional; Region: PRK00967 684738002911 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 684738002912 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 684738002913 Potassium binding sites [ion binding]; other site 684738002914 Cesium cation binding sites [ion binding]; other site 684738002915 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 684738002916 NlpC/P60 family; Region: NLPC_P60; pfam00877 684738002917 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 684738002918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 684738002919 substrate binding pocket [chemical binding]; other site 684738002920 membrane-bound complex binding site; other site 684738002921 hinge residues; other site 684738002922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738002923 dimer interface [polypeptide binding]; other site 684738002924 conserved gate region; other site 684738002925 putative PBP binding loops; other site 684738002926 ABC-ATPase subunit interface; other site 684738002927 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 684738002928 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 684738002929 Walker A/P-loop; other site 684738002930 ATP binding site [chemical binding]; other site 684738002931 Q-loop/lid; other site 684738002932 ABC transporter signature motif; other site 684738002933 Walker B; other site 684738002934 D-loop; other site 684738002935 H-loop/switch region; other site 684738002936 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 684738002937 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 684738002938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738002939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738002940 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 684738002941 ribonuclease R; Region: RNase_R; TIGR02063 684738002942 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 684738002943 RNB domain; Region: RNB; pfam00773 684738002944 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 684738002945 RNA binding site [nucleotide binding]; other site 684738002946 Isochorismatase family; Region: Isochorismatase; pfam00857 684738002947 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 684738002948 catalytic triad [active] 684738002949 conserved cis-peptide bond; other site 684738002950 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 684738002951 putative catalytic site [active] 684738002952 putative metal binding site [ion binding]; other site 684738002953 putative phosphate binding site [ion binding]; other site 684738002954 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 684738002955 UbiA prenyltransferase family; Region: UbiA; pfam01040 684738002956 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 684738002957 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 684738002958 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738002959 catalytic core [active] 684738002960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738002961 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 684738002962 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 684738002963 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 684738002964 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 684738002965 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 684738002966 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 684738002967 dimer interface [polypeptide binding]; other site 684738002968 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 684738002969 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 684738002970 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 684738002971 nucleotide binding site [chemical binding]; other site 684738002972 NEF interaction site [polypeptide binding]; other site 684738002973 SBD interface [polypeptide binding]; other site 684738002974 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 684738002975 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 684738002976 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 684738002977 metal binding site [ion binding]; metal-binding site 684738002978 dimer interface [polypeptide binding]; other site 684738002979 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 684738002980 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 684738002981 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 684738002982 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 684738002983 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 684738002984 putative substrate binding site [chemical binding]; other site 684738002985 putative ATP binding site [chemical binding]; other site 684738002986 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 684738002987 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 684738002988 active site 684738002989 phosphorylation site [posttranslational modification] 684738002990 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 684738002991 active site 684738002992 P-loop; other site 684738002993 phosphorylation site [posttranslational modification] 684738002994 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 684738002995 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 684738002996 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 684738002997 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 684738002998 putative active site [active] 684738002999 catalytic site [active] 684738003000 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 684738003001 putative active site [active] 684738003002 catalytic site [active] 684738003003 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 684738003004 AAA domain; Region: AAA_18; pfam13238 684738003005 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 684738003006 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 684738003007 dimer interface [polypeptide binding]; other site 684738003008 phosphate binding site [ion binding]; other site 684738003009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 684738003010 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 684738003011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738003012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738003013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 684738003014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738003015 Walker A/P-loop; other site 684738003016 ATP binding site [chemical binding]; other site 684738003017 Q-loop/lid; other site 684738003018 ABC transporter signature motif; other site 684738003019 Walker B; other site 684738003020 D-loop; other site 684738003021 H-loop/switch region; other site 684738003022 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 684738003023 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 684738003024 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 684738003025 hypothetical protein; Provisional; Region: PRK13662 684738003026 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 684738003027 putative phosphoesterase; Region: acc_ester; TIGR03729 684738003028 peptide chain release factor 2; Validated; Region: prfB; PRK00578 684738003029 This domain is found in peptide chain release factors; Region: PCRF; smart00937 684738003030 RF-1 domain; Region: RF-1; pfam00472 684738003031 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 684738003032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738003033 Walker A/P-loop; other site 684738003034 ATP binding site [chemical binding]; other site 684738003035 Q-loop/lid; other site 684738003036 ABC transporter signature motif; other site 684738003037 Walker B; other site 684738003038 D-loop; other site 684738003039 H-loop/switch region; other site 684738003040 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 684738003041 HD domain; Region: HD_3; cl17350 684738003042 FtsX-like permease family; Region: FtsX; pfam02687 684738003043 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 684738003044 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 684738003045 dimer interface [polypeptide binding]; other site 684738003046 putative radical transfer pathway; other site 684738003047 diiron center [ion binding]; other site 684738003048 tyrosyl radical; other site 684738003049 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 684738003050 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 684738003051 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 684738003052 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 684738003053 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 684738003054 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 684738003055 catalytic residues [active] 684738003056 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 684738003057 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 684738003058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738003059 Mg2+ binding site [ion binding]; other site 684738003060 G-X-G motif; other site 684738003061 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 684738003062 anchoring element; other site 684738003063 dimer interface [polypeptide binding]; other site 684738003064 ATP binding site [chemical binding]; other site 684738003065 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 684738003066 active site 684738003067 putative metal-binding site [ion binding]; other site 684738003068 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 684738003069 Hydrolase, isochorismatase family, N-terminal fragment; frameshift 684738003070 Hydrolase, isochorismatase family, C-terminal fragment; frameshift 684738003071 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 684738003072 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 684738003073 active site 684738003074 catalytic site [active] 684738003075 substrate binding site [chemical binding]; other site 684738003076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738003077 Coenzyme A binding pocket [chemical binding]; other site 684738003078 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 684738003079 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 684738003080 CAP-like domain; other site 684738003081 active site 684738003082 primary dimer interface [polypeptide binding]; other site 684738003083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003085 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 684738003086 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 684738003087 oligomer interface [polypeptide binding]; other site 684738003088 Cl binding site [ion binding]; other site 684738003089 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 684738003090 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 684738003091 catalytic motif [active] 684738003092 Zn binding site [ion binding]; other site 684738003093 RibD C-terminal domain; Region: RibD_C; cl17279 684738003094 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 684738003095 Lumazine binding domain; Region: Lum_binding; pfam00677 684738003096 Lumazine binding domain; Region: Lum_binding; pfam00677 684738003097 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 684738003098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 684738003099 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 684738003100 dimerization interface [polypeptide binding]; other site 684738003101 active site 684738003102 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 684738003103 homopentamer interface [polypeptide binding]; other site 684738003104 active site 684738003105 lipoprotein signal peptidase; Provisional; Region: PRK14797 684738003106 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 684738003107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738003108 RNA binding surface [nucleotide binding]; other site 684738003109 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 684738003110 active site 684738003111 Divergent PAP2 family; Region: DUF212; pfam02681 684738003112 conserved hypothetical integral membrane protein; Region: TIGR03766 684738003113 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 684738003114 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 684738003115 Ligand binding site; other site 684738003116 Putative Catalytic site; other site 684738003117 DXD motif; other site 684738003118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738003119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738003120 active site 684738003121 phosphorylation site [posttranslational modification] 684738003122 intermolecular recognition site; other site 684738003123 dimerization interface [polypeptide binding]; other site 684738003124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738003125 DNA binding site [nucleotide binding] 684738003126 Predicted membrane protein [Function unknown]; Region: COG4331 684738003127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738003128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 684738003129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738003130 dimer interface [polypeptide binding]; other site 684738003131 phosphorylation site [posttranslational modification] 684738003132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738003133 ATP binding site [chemical binding]; other site 684738003134 Mg2+ binding site [ion binding]; other site 684738003135 G-X-G motif; other site 684738003136 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 684738003137 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 684738003138 active site 684738003139 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 684738003140 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 684738003141 glutaminase active site [active] 684738003142 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 684738003143 dimer interface [polypeptide binding]; other site 684738003144 active site 684738003145 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 684738003146 dimer interface [polypeptide binding]; other site 684738003147 active site 684738003148 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 684738003149 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 684738003150 MPN+ (JAMM) motif; other site 684738003151 Zinc-binding site [ion binding]; other site 684738003152 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 684738003153 Int/Topo IB signature motif; other site 684738003154 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738003155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738003156 non-specific DNA binding site [nucleotide binding]; other site 684738003157 salt bridge; other site 684738003158 sequence-specific DNA binding site [nucleotide binding]; other site 684738003159 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 684738003160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 684738003161 putative transcription regulator; Provisional; Region: PHA02503 684738003162 Helix-turn-helix domain; Region: HTH_39; pfam14090 684738003163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738003164 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 684738003165 active site 684738003166 DNA binding site [nucleotide binding] 684738003167 Int/Topo IB signature motif; other site 684738003168 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 684738003169 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 684738003170 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 684738003171 Protein of unknown function (DUF658); Region: DUF658; pfam04936 684738003172 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 684738003173 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 684738003174 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 684738003175 substrate interaction site [chemical binding]; other site 684738003176 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 684738003177 DNA methylase; Region: N6_N4_Mtase; cl17433 684738003178 DNA methylase; Region: N6_N4_Mtase; pfam01555 684738003179 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 684738003180 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 684738003181 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 684738003182 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 684738003183 active site 684738003184 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 684738003185 Phage Terminase; Region: Terminase_1; pfam03354 684738003186 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 684738003187 Phage capsid family; Region: Phage_capsid; pfam05065 684738003188 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 684738003189 Phage-related protein [Function unknown]; Region: COG5412 684738003190 Phage tail protein; Region: Sipho_tail; pfam05709 684738003191 Phage tail protein; Region: Sipho_tail; cl17486 684738003192 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506 684738003193 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 684738003194 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 684738003195 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 684738003196 active site 684738003197 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 684738003198 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 684738003199 CoA binding domain; Region: CoA_binding; pfam02629 684738003200 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 684738003201 ArsC family; Region: ArsC; pfam03960 684738003202 putative catalytic residues [active] 684738003203 thiol/disulfide switch; other site 684738003204 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 684738003205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738003206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738003207 ABC transporter; Region: ABC_tran_2; pfam12848 684738003208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738003209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738003210 non-specific DNA binding site [nucleotide binding]; other site 684738003211 salt bridge; other site 684738003212 sequence-specific DNA binding site [nucleotide binding]; other site 684738003213 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738003214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738003215 active site 684738003216 dihydroorotase; Validated; Region: pyrC; PRK09357 684738003217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 684738003218 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 684738003219 active site 684738003220 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 684738003221 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 684738003222 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 684738003223 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 684738003224 minor groove reading motif; other site 684738003225 helix-hairpin-helix signature motif; other site 684738003226 substrate binding pocket [chemical binding]; other site 684738003227 active site 684738003228 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 684738003229 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 684738003230 Family of unknown function (DUF633); Region: DUF633; pfam04816 684738003231 Uncharacterized conserved protein [Function unknown]; Region: COG0327 684738003232 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 684738003233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 684738003234 sugar phosphate phosphatase; Provisional; Region: PRK10513 684738003235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738003236 active site 684738003237 motif I; other site 684738003238 motif II; other site 684738003239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738003240 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 684738003241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738003242 Zn2+ binding site [ion binding]; other site 684738003243 Mg2+ binding site [ion binding]; other site 684738003244 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 684738003245 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 684738003246 Predicted membrane protein [Function unknown]; Region: COG3371 684738003247 Protein of unknown function (DUF998); Region: DUF998; pfam06197 684738003248 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 684738003249 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 684738003250 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 684738003251 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 684738003252 manganese transport protein MntH; Reviewed; Region: PRK00701 684738003253 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 684738003254 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 684738003255 PhoH-like protein; Region: PhoH; pfam02562 684738003256 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 684738003257 nudix motif; other site 684738003258 metal-binding heat shock protein; Provisional; Region: PRK00016 684738003259 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 684738003260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 684738003261 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 684738003262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738003263 active site 684738003264 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 684738003265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738003266 ATP binding site [chemical binding]; other site 684738003267 putative Mg++ binding site [ion binding]; other site 684738003268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738003269 nucleotide binding region [chemical binding]; other site 684738003270 ATP-binding site [chemical binding]; other site 684738003271 Uncharacterized conserved protein [Function unknown]; Region: COG1739 684738003272 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 684738003273 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 684738003274 VanZ like family; Region: VanZ; pfam04892 684738003275 hypothetical protein; Provisional; Region: PRK14013 684738003276 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 684738003277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 684738003278 active site 684738003279 metal binding site [ion binding]; metal-binding site 684738003280 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 684738003281 motif 1; other site 684738003282 dimer interface [polypeptide binding]; other site 684738003283 active site 684738003284 motif 2; other site 684738003285 motif 3; other site 684738003286 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 684738003287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 684738003288 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 684738003289 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 684738003290 putative Cl- selectivity filter; other site 684738003291 putative pore gating glutamate residue; other site 684738003292 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 684738003293 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 684738003294 active site 684738003295 (T/H)XGH motif; other site 684738003296 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 684738003297 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 684738003298 active site 684738003299 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 684738003300 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 684738003301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738003302 Coenzyme A binding pocket [chemical binding]; other site 684738003303 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 684738003304 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 684738003305 homodimer interface [polypeptide binding]; other site 684738003306 NAD binding pocket [chemical binding]; other site 684738003307 ATP binding pocket [chemical binding]; other site 684738003308 Mg binding site [ion binding]; other site 684738003309 active-site loop [active] 684738003310 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738003311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738003312 Walker A/P-loop; other site 684738003313 ATP binding site [chemical binding]; other site 684738003314 Q-loop/lid; other site 684738003315 ABC transporter signature motif; other site 684738003316 Walker B; other site 684738003317 D-loop; other site 684738003318 H-loop/switch region; other site 684738003319 FtsX-like permease family; Region: FtsX; pfam02687 684738003320 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 684738003321 FtsX-like permease family; Region: FtsX; pfam02687 684738003322 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 684738003323 catalytic triad [active] 684738003324 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 684738003325 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738003326 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 684738003327 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 684738003328 GTP-binding protein LepA; Provisional; Region: PRK05433 684738003329 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 684738003330 G1 box; other site 684738003331 putative GEF interaction site [polypeptide binding]; other site 684738003332 GTP/Mg2+ binding site [chemical binding]; other site 684738003333 Switch I region; other site 684738003334 G2 box; other site 684738003335 G3 box; other site 684738003336 Switch II region; other site 684738003337 G4 box; other site 684738003338 G5 box; other site 684738003339 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 684738003340 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 684738003341 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 684738003342 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 684738003343 NADH(P)-binding; Region: NAD_binding_10; pfam13460 684738003344 NAD(P) binding site [chemical binding]; other site 684738003345 putative active site [active] 684738003346 Amino acid permease; Region: AA_permease_2; pfam13520 684738003347 DNA gyrase subunit A; Validated; Region: PRK05560 684738003348 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 684738003349 CAP-like domain; other site 684738003350 active site 684738003351 primary dimer interface [polypeptide binding]; other site 684738003352 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003353 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003354 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003355 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003356 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003357 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 684738003358 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 684738003359 ApbE family; Region: ApbE; pfam02424 684738003360 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 684738003361 active site 684738003362 catalytic site [active] 684738003363 Hypothetical protein, N-terminal fragment; frameshift 684738003364 Hypothetical protein, C-terminal fragment; frameshift 684738003365 Uncharacterized conserved protein [Function unknown]; Region: COG2898 684738003366 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 684738003367 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 684738003368 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 684738003369 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 684738003370 dimer interface [polypeptide binding]; other site 684738003371 putative anticodon binding site; other site 684738003372 Protein of unknown function (DUF998); Region: DUF998; pfam06197 684738003373 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 684738003374 Part of AAA domain; Region: AAA_19; pfam13245 684738003375 Family description; Region: UvrD_C_2; pfam13538 684738003376 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 684738003377 putative active site [active] 684738003378 nucleotide binding site [chemical binding]; other site 684738003379 nudix motif; other site 684738003380 putative metal binding site [ion binding]; other site 684738003381 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 684738003382 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 684738003383 dimer interface [polypeptide binding]; other site 684738003384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 684738003385 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 684738003386 L-aspartate oxidase; Provisional; Region: PRK06175 684738003387 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 684738003388 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 684738003389 RNA binding site [nucleotide binding]; other site 684738003390 active site 684738003391 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 684738003392 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 684738003393 active site 684738003394 Riboflavin kinase; Region: Flavokinase; smart00904 684738003395 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 684738003396 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 684738003397 dimer interface [polypeptide binding]; other site 684738003398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738003399 NAD binding site [chemical binding]; other site 684738003400 substrate binding site [chemical binding]; other site 684738003401 Uncharacterized conserved protein [Function unknown]; Region: COG3589 684738003402 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 684738003403 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 684738003404 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 684738003405 putative active site [active] 684738003406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738003407 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 684738003408 active site turn [active] 684738003409 phosphorylation site [posttranslational modification] 684738003410 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738003411 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 684738003412 HPr interaction site; other site 684738003413 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738003414 active site 684738003415 phosphorylation site [posttranslational modification] 684738003416 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738003417 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738003418 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738003419 putative active site [active] 684738003420 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 684738003421 triosephosphate isomerase; Provisional; Region: PRK14565 684738003422 substrate binding site [chemical binding]; other site 684738003423 dimer interface [polypeptide binding]; other site 684738003424 catalytic triad [active] 684738003425 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 684738003426 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 684738003427 active site 684738003428 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 684738003429 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 684738003430 Active Sites [active] 684738003431 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 684738003432 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 684738003433 ParB-like nuclease domain; Region: ParBc; pfam02195 684738003434 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 684738003435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738003436 FeS/SAM binding site; other site 684738003437 HemN C-terminal domain; Region: HemN_C; pfam06969 684738003438 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 684738003439 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 684738003440 active site 684738003441 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 684738003442 catalytic motif [active] 684738003443 Zn binding site [ion binding]; other site 684738003444 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 684738003445 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 684738003446 active site 684738003447 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 684738003448 active site 2 [active] 684738003449 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 684738003450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738003451 active site 684738003452 motif I; other site 684738003453 motif II; other site 684738003454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738003455 Predicted membrane protein [Function unknown]; Region: COG4478 684738003456 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 684738003457 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 684738003458 active site 684738003459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738003460 active site 684738003461 xanthine permease; Region: pbuX; TIGR03173 684738003462 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 684738003463 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 684738003464 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 684738003465 folate binding site [chemical binding]; other site 684738003466 NADP+ binding site [chemical binding]; other site 684738003467 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 684738003468 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 684738003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738003470 Walker A motif; other site 684738003471 ATP binding site [chemical binding]; other site 684738003472 Walker B motif; other site 684738003473 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 684738003474 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 684738003475 G1 box; other site 684738003476 GTP/Mg2+ binding site [chemical binding]; other site 684738003477 Switch I region; other site 684738003478 G2 box; other site 684738003479 G3 box; other site 684738003480 Switch II region; other site 684738003481 G4 box; other site 684738003482 G5 box; other site 684738003483 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 684738003484 active site 684738003485 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 684738003486 catalytic center binding site [active] 684738003487 ATP binding site [chemical binding]; other site 684738003488 GTP cyclohydrolase I [Coenzyme metabolism]; Region: FolE; COG0302 684738003489 GTP cyclohydrolase I; Provisional; Region: PLN03044 684738003490 active site 684738003491 dihydropteroate synthase; Region: DHPS; TIGR01496 684738003492 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 684738003493 substrate binding pocket [chemical binding]; other site 684738003494 dimer interface [polypeptide binding]; other site 684738003495 inhibitor binding site; inhibition site 684738003496 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 684738003497 nudix motif; other site 684738003498 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 684738003499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738003500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 684738003501 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 684738003502 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 684738003503 Substrate-binding site [chemical binding]; other site 684738003504 Substrate specificity [chemical binding]; other site 684738003505 homoserine dehydrogenase; Provisional; Region: PRK06349 684738003506 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 684738003507 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 684738003508 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 684738003509 homoserine kinase; Provisional; Region: PRK01212 684738003510 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 684738003511 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 684738003512 FAD binding domain; Region: FAD_binding_4; pfam01565 684738003513 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 684738003514 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 684738003515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738003516 Walker A/P-loop; other site 684738003517 ATP binding site [chemical binding]; other site 684738003518 Q-loop/lid; other site 684738003519 ABC transporter signature motif; other site 684738003520 Walker B; other site 684738003521 D-loop; other site 684738003522 H-loop/switch region; other site 684738003523 TOBE domain; Region: TOBE_2; pfam08402 684738003524 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 684738003525 dimer interface [polypeptide binding]; other site 684738003526 conserved gate region; other site 684738003527 putative PBP binding loops; other site 684738003528 ABC-ATPase subunit interface; other site 684738003529 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 684738003530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738003531 dimer interface [polypeptide binding]; other site 684738003532 conserved gate region; other site 684738003533 putative PBP binding loops; other site 684738003534 ABC-ATPase subunit interface; other site 684738003535 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 684738003536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 684738003537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 684738003538 Glyoxalase family protein, N-terminal fragment; frameshift 684738003539 Glyoxalase family protein, C-terminal fragment; frameshift 684738003540 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 684738003541 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738003542 DNA-binding site [nucleotide binding]; DNA binding site 684738003543 RNA-binding motif; other site 684738003544 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 684738003545 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 684738003546 putative active site [active] 684738003547 catalytic site [active] 684738003548 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 684738003549 putative active site [active] 684738003550 catalytic site [active] 684738003551 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 684738003552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738003553 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 684738003554 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 684738003555 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 684738003556 putative active site cavity [active] 684738003557 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 684738003558 TRAM domain; Region: TRAM; cl01282 684738003559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738003560 S-adenosylmethionine binding site [chemical binding]; other site 684738003561 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 684738003562 Methyltransferase domain; Region: Methyltransf_31; pfam13847 684738003563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738003564 S-adenosylmethionine binding site [chemical binding]; other site 684738003565 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 684738003566 Domain of unknown function DUF20; Region: UPF0118; pfam01594 684738003567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 684738003568 binding surface 684738003569 TPR motif; other site 684738003570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 684738003571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 684738003572 binding surface 684738003573 TPR motif; other site 684738003574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 684738003575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 684738003576 binding surface 684738003577 TPR motif; other site 684738003578 acetolactate synthase; Reviewed; Region: PRK08617 684738003579 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 684738003580 PYR/PP interface [polypeptide binding]; other site 684738003581 dimer interface [polypeptide binding]; other site 684738003582 TPP binding site [chemical binding]; other site 684738003583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 684738003584 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 684738003585 TPP-binding site [chemical binding]; other site 684738003586 I/LWEQ domain; Region: I_LWEQ; pfam01608 684738003587 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 684738003588 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 684738003589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 684738003590 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 684738003591 Mg2+ binding site [ion binding]; other site 684738003592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 684738003593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738003594 active site 684738003595 phosphorylation site [posttranslational modification] 684738003596 intermolecular recognition site; other site 684738003597 dimerization interface [polypeptide binding]; other site 684738003598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 684738003599 DNA binding residues [nucleotide binding] 684738003600 dimerization interface [polypeptide binding]; other site 684738003601 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003602 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 684738003603 acyl-activating enzyme (AAE) consensus motif; other site 684738003604 AMP binding site [chemical binding]; other site 684738003605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003606 peptide synthase; Provisional; Region: PRK12316 684738003607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 684738003608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003609 acyl-activating enzyme (AAE) consensus motif; other site 684738003610 AMP binding site [chemical binding]; other site 684738003611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003612 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 684738003613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003614 acyl-activating enzyme (AAE) consensus motif; other site 684738003615 AMP binding site [chemical binding]; other site 684738003616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003617 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 684738003618 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003619 acyl-activating enzyme (AAE) consensus motif; other site 684738003620 AMP binding site [chemical binding]; other site 684738003621 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 684738003622 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003623 acyl-activating enzyme (AAE) consensus motif; other site 684738003624 AMP binding site [chemical binding]; other site 684738003625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003626 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 684738003627 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 684738003628 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 684738003629 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 684738003630 active site 684738003631 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 684738003632 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 684738003633 KR domain; Region: KR; pfam08659 684738003634 putative NADP binding site [chemical binding]; other site 684738003635 active site 684738003636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003637 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 684738003638 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 684738003639 active site 684738003640 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 684738003641 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 684738003642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 684738003643 putative NADP binding site [chemical binding]; other site 684738003644 active site 684738003645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003646 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738003647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 684738003648 Walker A/P-loop; other site 684738003649 ATP binding site [chemical binding]; other site 684738003650 Q-loop/lid; other site 684738003651 ABC transporter signature motif; other site 684738003652 Walker B; other site 684738003653 D-loop; other site 684738003654 H-loop/switch region; other site 684738003655 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 684738003656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 684738003657 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 684738003658 active site 684738003659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003660 Condensation domain; Region: Condensation; pfam00668 684738003661 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 684738003662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 684738003663 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 684738003664 acyl-activating enzyme (AAE) consensus motif; other site 684738003665 AMP binding site [chemical binding]; other site 684738003666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 684738003667 Condensation domain; Region: Condensation; pfam00668 684738003668 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 684738003669 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 684738003670 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 684738003671 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 684738003672 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 684738003673 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 684738003674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 684738003675 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 684738003676 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 684738003677 Transposase, IS1562, N-terminal fragment 684738003678 Transposase, IS1562, fragment 684738003679 Transposase, fragment 684738003680 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738003681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738003682 active site 684738003683 DNA binding site [nucleotide binding] 684738003684 Int/Topo IB signature motif; other site 684738003685 Hypothetical protein, N-terminal fragment; stop codon 684738003686 Hypothetical protein, C-terminal fragment; stop codon 684738003687 SEFIR domain; Region: SEFIR; pfam08357 684738003688 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 684738003689 legume lectins; Region: lectin_L-type; cl14058 684738003690 carbohydrate binding site [chemical binding]; other site 684738003691 metal binding site [ion binding]; metal-binding site 684738003692 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 684738003693 domain interaction interfaces [polypeptide binding]; other site 684738003694 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 684738003695 domain interaction interfaces [polypeptide binding]; other site 684738003696 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 684738003697 domain interaction interfaces [polypeptide binding]; other site 684738003698 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 684738003699 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 684738003700 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 684738003701 Ligand Binding Site [chemical binding]; other site 684738003702 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 684738003703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738003704 dimer interface [polypeptide binding]; other site 684738003705 phosphorylation site [posttranslational modification] 684738003706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738003707 ATP binding site [chemical binding]; other site 684738003708 Mg2+ binding site [ion binding]; other site 684738003709 G-X-G motif; other site 684738003710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738003711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738003712 active site 684738003713 phosphorylation site [posttranslational modification] 684738003714 intermolecular recognition site; other site 684738003715 dimerization interface [polypeptide binding]; other site 684738003716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738003717 DNA binding site [nucleotide binding] 684738003718 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 684738003719 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 684738003720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738003721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738003722 K+-transporting ATPase, c chain; Region: KdpC; cl00944 684738003723 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738003724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738003725 non-specific DNA binding site [nucleotide binding]; other site 684738003726 salt bridge; other site 684738003727 sequence-specific DNA binding site [nucleotide binding]; other site 684738003728 Mucus-binding protein, N-terminal fragment 684738003729 Mucus-binding protein, LPXTG-anchored, C-terminal fragment 684738003730 ribonuclease R; Region: RNase_R; TIGR02063 684738003731 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 684738003732 RNB domain; Region: RNB; pfam00773 684738003733 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 684738003734 RNA binding site [nucleotide binding]; other site 684738003735 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 684738003736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738003737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738003738 homodimer interface [polypeptide binding]; other site 684738003739 catalytic residue [active] 684738003740 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 684738003741 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 684738003742 dimer interface [polypeptide binding]; other site 684738003743 motif 1; other site 684738003744 active site 684738003745 motif 2; other site 684738003746 motif 3; other site 684738003747 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 684738003748 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 684738003749 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 684738003750 histidinol dehydrogenase; Region: hisD; TIGR00069 684738003751 NAD binding site [chemical binding]; other site 684738003752 dimerization interface [polypeptide binding]; other site 684738003753 product binding site; other site 684738003754 substrate binding site [chemical binding]; other site 684738003755 zinc binding site [ion binding]; other site 684738003756 catalytic residues [active] 684738003757 Methyltransferase domain; Region: Methyltransf_23; pfam13489 684738003758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 684738003759 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 684738003760 putative active site pocket [active] 684738003761 4-fold oligomerization interface [polypeptide binding]; other site 684738003762 metal binding residues [ion binding]; metal-binding site 684738003763 3-fold/trimer interface [polypeptide binding]; other site 684738003764 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 684738003765 active site 684738003766 ATP binding site [chemical binding]; other site 684738003767 Phosphotransferase enzyme family; Region: APH; pfam01636 684738003768 antibiotic binding site [chemical binding]; other site 684738003769 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 684738003770 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 684738003771 putative active site [active] 684738003772 oxyanion strand; other site 684738003773 catalytic triad [active] 684738003774 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 684738003775 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 684738003776 catalytic residues [active] 684738003777 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 684738003778 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 684738003779 substrate binding site [chemical binding]; other site 684738003780 glutamase interaction surface [polypeptide binding]; other site 684738003781 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 684738003782 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 684738003783 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 684738003784 metal binding site [ion binding]; metal-binding site 684738003785 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 684738003786 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 684738003787 active site 684738003788 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 684738003789 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 684738003790 active site residue [active] 684738003791 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 684738003792 2-isopropylmalate synthase; Validated; Region: PRK00915 684738003793 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 684738003794 active site 684738003795 catalytic residues [active] 684738003796 metal binding site [ion binding]; metal-binding site 684738003797 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 684738003798 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 684738003799 tartrate dehydrogenase; Region: TTC; TIGR02089 684738003800 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 684738003801 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 684738003802 substrate binding site [chemical binding]; other site 684738003803 ligand binding site [chemical binding]; other site 684738003804 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 684738003805 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 684738003806 substrate binding site [chemical binding]; other site 684738003807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 684738003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 684738003809 Walker A/P-loop; other site 684738003810 ATP binding site [chemical binding]; other site 684738003811 Q-loop/lid; other site 684738003812 ABC transporter signature motif; other site 684738003813 Walker B; other site 684738003814 D-loop; other site 684738003815 H-loop/switch region; other site 684738003816 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 684738003817 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 684738003818 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 684738003819 PYR/PP interface [polypeptide binding]; other site 684738003820 dimer interface [polypeptide binding]; other site 684738003821 TPP binding site [chemical binding]; other site 684738003822 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 684738003823 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 684738003824 TPP-binding site [chemical binding]; other site 684738003825 dimer interface [polypeptide binding]; other site 684738003826 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 684738003827 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 684738003828 putative valine binding site [chemical binding]; other site 684738003829 dimer interface [polypeptide binding]; other site 684738003830 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 684738003831 ketol-acid reductoisomerase; Provisional; Region: PRK05479 684738003832 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 684738003833 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 684738003834 threonine dehydratase; Validated; Region: PRK08639 684738003835 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 684738003836 tetramer interface [polypeptide binding]; other site 684738003837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738003838 catalytic residue [active] 684738003839 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 684738003840 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 684738003841 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 684738003842 homotrimer interaction site [polypeptide binding]; other site 684738003843 putative active site [active] 684738003844 DNA protecting protein DprA; Region: dprA; TIGR00732 684738003845 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 684738003846 DNA topoisomerase I; Validated; Region: PRK05582 684738003847 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 684738003848 active site 684738003849 interdomain interaction site; other site 684738003850 putative metal-binding site [ion binding]; other site 684738003851 nucleotide binding site [chemical binding]; other site 684738003852 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 684738003853 domain I; other site 684738003854 DNA binding groove [nucleotide binding] 684738003855 phosphate binding site [ion binding]; other site 684738003856 domain II; other site 684738003857 domain III; other site 684738003858 nucleotide binding site [chemical binding]; other site 684738003859 catalytic site [active] 684738003860 domain IV; other site 684738003861 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 684738003862 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 684738003863 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 684738003864 Glucose inhibited division protein A; Region: GIDA; pfam01134 684738003865 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 684738003866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738003867 active site 684738003868 DNA binding site [nucleotide binding] 684738003869 Int/Topo IB signature motif; other site 684738003870 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 684738003871 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738003872 active site 684738003873 DNA binding site [nucleotide binding] 684738003874 Int/Topo IB signature motif; other site 684738003875 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 684738003876 inhibitor site; inhibition site 684738003877 active site 684738003878 dimer interface [polypeptide binding]; other site 684738003879 catalytic residue [active] 684738003880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738003881 H+ Antiporter protein; Region: 2A0121; TIGR00900 684738003882 putative substrate translocation pore; other site 684738003883 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 684738003884 B3/4 domain; Region: B3_4; pfam03483 684738003885 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 684738003886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738003887 Coenzyme A binding pocket [chemical binding]; other site 684738003888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738003889 MarR family; Region: MarR; pfam01047 684738003890 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 684738003891 Walker B motif; other site 684738003892 Transposase; Region: HTH_Tnp_1; pfam01527 684738003893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738003894 putative transposase OrfB; Reviewed; Region: PHA02517 684738003895 HTH-like domain; Region: HTH_21; pfam13276 684738003896 Integrase core domain; Region: rve; pfam00665 684738003897 Integrase core domain; Region: rve_3; pfam13683 684738003898 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 684738003899 putative active site; other site 684738003900 putative metal binding residues [ion binding]; other site 684738003901 signature motif; other site 684738003902 putative triphosphate binding site [ion binding]; other site 684738003903 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 684738003904 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 684738003905 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 684738003906 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 684738003907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738003908 Walker A/P-loop; other site 684738003909 ATP binding site [chemical binding]; other site 684738003910 Q-loop/lid; other site 684738003911 ABC transporter signature motif; other site 684738003912 Walker B; other site 684738003913 D-loop; other site 684738003914 H-loop/switch region; other site 684738003915 Hypothetical protein, C-terminal fragment; frameshift 684738003916 Hypothetical protein, N-terminal fragment; frameshift 684738003917 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 684738003918 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 684738003919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 684738003920 acyl-activating enzyme (AAE) consensus motif; other site 684738003921 acyl-activating enzyme (AAE) consensus motif; other site 684738003922 AMP binding site [chemical binding]; other site 684738003923 active site 684738003924 CoA binding site [chemical binding]; other site 684738003925 Phosphopantetheine attachment site; Region: PP-binding; cl09936 684738003926 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 684738003927 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 684738003928 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 684738003929 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 684738003930 Walker A/P-loop; other site 684738003931 ATP binding site [chemical binding]; other site 684738003932 Q-loop/lid; other site 684738003933 ABC transporter signature motif; other site 684738003934 Walker B; other site 684738003935 D-loop; other site 684738003936 H-loop/switch region; other site 684738003937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738003938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738003939 dimer interface [polypeptide binding]; other site 684738003940 phosphorylation site [posttranslational modification] 684738003941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738003942 ATP binding site [chemical binding]; other site 684738003943 Mg2+ binding site [ion binding]; other site 684738003944 G-X-G motif; other site 684738003945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738003946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738003947 active site 684738003948 phosphorylation site [posttranslational modification] 684738003949 intermolecular recognition site; other site 684738003950 dimerization interface [polypeptide binding]; other site 684738003951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738003952 DNA binding site [nucleotide binding] 684738003953 Nisin leader peptide-processing serine protease NisP, C-terminal fragment; stop codon 684738003954 Nisin leader peptide-processing serine protease NisP, middle fragment; stop codon 684738003955 Nisin leader peptide-processing serine protease NisP, N-terminal fragment; stop codon 684738003956 Nisin synthetase, cyclase protein, C-terminal fragment 684738003957 Nisin synthetase, dehydratase protein, N-terminal fragment 684738003958 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 684738003959 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 684738003960 amphipathic channel; other site 684738003961 Asn-Pro-Ala signature motifs; other site 684738003962 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 684738003963 glycerol kinase; Provisional; Region: glpK; PRK00047 684738003964 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 684738003965 N- and C-terminal domain interface [polypeptide binding]; other site 684738003966 active site 684738003967 MgATP binding site [chemical binding]; other site 684738003968 catalytic site [active] 684738003969 metal binding site [ion binding]; metal-binding site 684738003970 glycerol binding site [chemical binding]; other site 684738003971 homotetramer interface [polypeptide binding]; other site 684738003972 homodimer interface [polypeptide binding]; other site 684738003973 FBP binding site [chemical binding]; other site 684738003974 protein IIAGlc interface [polypeptide binding]; other site 684738003975 Mga helix-turn-helix domain; Region: Mga; pfam05043 684738003976 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 684738003977 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 684738003978 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 684738003979 active site 684738003980 Na/Ca binding site [ion binding]; other site 684738003981 catalytic site [active] 684738003982 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 684738003983 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 684738003984 teramer interface [polypeptide binding]; other site 684738003985 active site 684738003986 FMN binding site [chemical binding]; other site 684738003987 catalytic residues [active] 684738003988 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 684738003989 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 684738003990 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 684738003991 FAD binding site [chemical binding]; other site 684738003992 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 684738003993 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 684738003994 THF binding site; other site 684738003995 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 684738003996 substrate binding site [chemical binding]; other site 684738003997 THF binding site; other site 684738003998 zinc-binding site [ion binding]; other site 684738003999 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 684738004000 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 684738004001 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 684738004002 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 684738004003 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 684738004004 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738004005 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 684738004006 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 684738004007 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738004008 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 684738004009 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 684738004010 DltD N-terminal region; Region: DltD_N; pfam04915 684738004011 DltD central region; Region: DltD_M; pfam04918 684738004012 DltD C-terminal region; Region: DltD_C; pfam04914 684738004013 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 684738004014 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 684738004015 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 684738004016 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 684738004017 acyl-activating enzyme (AAE) consensus motif; other site 684738004018 AMP binding site [chemical binding]; other site 684738004019 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 684738004020 thiamine phosphate binding site [chemical binding]; other site 684738004021 active site 684738004022 pyrophosphate binding site [ion binding]; other site 684738004023 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 684738004024 substrate binding site [chemical binding]; other site 684738004025 dimer interface [polypeptide binding]; other site 684738004026 ATP binding site [chemical binding]; other site 684738004027 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 684738004028 substrate binding site [chemical binding]; other site 684738004029 multimerization interface [polypeptide binding]; other site 684738004030 ATP binding site [chemical binding]; other site 684738004031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 684738004032 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 684738004033 DXD motif; other site 684738004034 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 684738004035 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 684738004036 active site 684738004037 homodimer interface [polypeptide binding]; other site 684738004038 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 684738004039 core dimer interface [polypeptide binding]; other site 684738004040 peripheral dimer interface [polypeptide binding]; other site 684738004041 L10 interface [polypeptide binding]; other site 684738004042 L11 interface [polypeptide binding]; other site 684738004043 putative EF-Tu interaction site [polypeptide binding]; other site 684738004044 putative EF-G interaction site [polypeptide binding]; other site 684738004045 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 684738004046 23S rRNA interface [nucleotide binding]; other site 684738004047 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 684738004048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738004049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004050 non-specific DNA binding site [nucleotide binding]; other site 684738004051 salt bridge; other site 684738004052 sequence-specific DNA binding site [nucleotide binding]; other site 684738004053 Predicted transcriptional regulator [Transcription]; Region: COG2932 684738004054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 684738004055 Catalytic site [active] 684738004056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738004057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738004058 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 684738004059 Walker A/P-loop; other site 684738004060 ATP binding site [chemical binding]; other site 684738004061 Q-loop/lid; other site 684738004062 ABC transporter signature motif; other site 684738004063 Walker B; other site 684738004064 D-loop; other site 684738004065 H-loop/switch region; other site 684738004066 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738004067 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 684738004068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738004069 Walker A/P-loop; other site 684738004070 ATP binding site [chemical binding]; other site 684738004071 Q-loop/lid; other site 684738004072 ABC transporter signature motif; other site 684738004073 Walker B; other site 684738004074 D-loop; other site 684738004075 H-loop/switch region; other site 684738004076 Predicted membrane protein [Function unknown]; Region: COG3601 684738004077 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 684738004078 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 684738004079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738004080 RNA binding surface [nucleotide binding]; other site 684738004081 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 684738004082 active site 684738004083 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 684738004084 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 684738004085 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 684738004086 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 684738004087 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 684738004088 DNA binding site [nucleotide binding] 684738004089 FOG: CBS domain [General function prediction only]; Region: COG0517 684738004090 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 684738004091 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 684738004092 active site 684738004093 metal binding site [ion binding]; metal-binding site 684738004094 homotetramer interface [polypeptide binding]; other site 684738004095 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 684738004096 active site 684738004097 dimerization interface [polypeptide binding]; other site 684738004098 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 684738004099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 684738004100 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 684738004101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 684738004102 active site 684738004103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 684738004104 substrate binding site [chemical binding]; other site 684738004105 catalytic residues [active] 684738004106 dimer interface [polypeptide binding]; other site 684738004107 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 684738004108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 684738004109 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 684738004110 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 684738004111 active site 684738004112 dimer interface [polypeptide binding]; other site 684738004113 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 684738004114 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 684738004115 active site 684738004116 FMN binding site [chemical binding]; other site 684738004117 substrate binding site [chemical binding]; other site 684738004118 3Fe-4S cluster binding site [ion binding]; other site 684738004119 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 684738004120 domain interface; other site 684738004121 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 684738004122 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 684738004123 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 684738004124 homodimer interface [polypeptide binding]; other site 684738004125 substrate-cofactor binding pocket; other site 684738004126 catalytic residue [active] 684738004127 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 684738004128 Mechanosensitive ion channel; Region: MS_channel; pfam00924 684738004129 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 684738004130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738004131 catalytic residue [active] 684738004132 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 684738004133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004134 non-specific DNA binding site [nucleotide binding]; other site 684738004135 salt bridge; other site 684738004136 sequence-specific DNA binding site [nucleotide binding]; other site 684738004137 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738004138 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 684738004139 RNA/DNA hybrid binding site [nucleotide binding]; other site 684738004140 active site 684738004141 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 684738004142 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 684738004143 GTP/Mg2+ binding site [chemical binding]; other site 684738004144 G4 box; other site 684738004145 G5 box; other site 684738004146 G1 box; other site 684738004147 Switch I region; other site 684738004148 G2 box; other site 684738004149 G3 box; other site 684738004150 Switch II region; other site 684738004151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 684738004152 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 684738004153 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 684738004154 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 684738004155 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 684738004156 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 684738004157 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 684738004158 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 684738004159 active site 684738004160 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 684738004161 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 684738004162 metal binding site [ion binding]; metal-binding site 684738004163 Predicted periplasmic or secreted protein [General function prediction only]; Region: COG3443 684738004164 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 684738004165 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 684738004166 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 684738004167 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 684738004168 NodB motif; other site 684738004169 active site 684738004170 catalytic site [active] 684738004171 metal binding site [ion binding]; metal-binding site 684738004172 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 684738004173 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738004174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004175 dimer interface [polypeptide binding]; other site 684738004176 conserved gate region; other site 684738004177 putative PBP binding loops; other site 684738004178 ABC-ATPase subunit interface; other site 684738004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004180 dimer interface [polypeptide binding]; other site 684738004181 conserved gate region; other site 684738004182 putative PBP binding loops; other site 684738004183 ABC-ATPase subunit interface; other site 684738004184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 684738004185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 684738004186 Domain of unknown function (DUF303); Region: DUF303; pfam03629 684738004187 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 684738004188 Domain of unknown function (DUF303); Region: DUF303; pfam03629 684738004189 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 684738004190 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 684738004191 cofactor binding site; other site 684738004192 DNA binding site [nucleotide binding] 684738004193 substrate interaction site [chemical binding]; other site 684738004194 Restriction endonuclease BpuJI - N terminal; Region: BpuJI_N; pfam11564 684738004195 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 684738004196 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 684738004197 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 684738004198 cofactor binding site; other site 684738004199 DNA binding site [nucleotide binding] 684738004200 substrate interaction site [chemical binding]; other site 684738004201 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 684738004202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 684738004203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 684738004204 transmembrane helices; other site 684738004205 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 684738004206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738004207 catalytic core [active] 684738004208 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 684738004209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738004210 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738004211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 684738004212 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738004213 active site 684738004214 motif I; other site 684738004215 motif II; other site 684738004216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738004217 maltose O-acetyltransferase; Provisional; Region: PRK10092 684738004218 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 684738004219 active site 684738004220 substrate binding site [chemical binding]; other site 684738004221 trimer interface [polypeptide binding]; other site 684738004222 CoA binding site [chemical binding]; other site 684738004223 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 684738004224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 684738004225 active site 684738004226 metal binding site [ion binding]; metal-binding site 684738004227 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 684738004228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 684738004229 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 684738004230 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 684738004231 dimer interface [polypeptide binding]; other site 684738004232 PYR/PP interface [polypeptide binding]; other site 684738004233 TPP binding site [chemical binding]; other site 684738004234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 684738004235 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 684738004236 TPP-binding site [chemical binding]; other site 684738004237 dimer interface [polypeptide binding]; other site 684738004238 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738004239 MarR family; Region: MarR_2; pfam12802 684738004240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738004241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738004242 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 684738004243 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 684738004244 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 684738004245 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 684738004246 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 684738004247 ArsC family; Region: ArsC; pfam03960 684738004248 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 684738004249 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 684738004250 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 684738004251 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 684738004252 substrate-cofactor binding pocket; other site 684738004253 homodimer interface [polypeptide binding]; other site 684738004254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738004255 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 684738004256 catalytic residue [active] 684738004257 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 684738004258 Glutamine amidotransferase class-I; Region: GATase; pfam00117 684738004259 glutamine binding [chemical binding]; other site 684738004260 catalytic triad [active] 684738004261 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 684738004262 active site 684738004263 catalytic site [active] 684738004264 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 684738004265 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 684738004266 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738004267 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738004268 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738004269 plasmid segregation protein ParM; Provisional; Region: PRK13917 684738004270 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 684738004271 Mg binding site [ion binding]; other site 684738004272 nucleotide binding site [chemical binding]; other site 684738004273 putative protofilament interface [polypeptide binding]; other site 684738004274 phosphodiesterase; Provisional; Region: PRK12704 684738004275 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 684738004276 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 684738004277 metal binding site [ion binding]; metal-binding site 684738004278 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 684738004279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738004280 ABC-ATPase subunit interface; other site 684738004281 dimer interface [polypeptide binding]; other site 684738004282 putative PBP binding regions; other site 684738004283 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 684738004284 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 684738004285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 684738004286 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 684738004287 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 684738004288 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 684738004289 Walker A/P-loop; other site 684738004290 ATP binding site [chemical binding]; other site 684738004291 Q-loop/lid; other site 684738004292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738004293 ABC transporter signature motif; other site 684738004294 Walker B; other site 684738004295 D-loop; other site 684738004296 H-loop/switch region; other site 684738004297 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 684738004298 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 684738004299 active site 684738004300 metal binding site [ion binding]; metal-binding site 684738004301 DNA binding site [nucleotide binding] 684738004302 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 684738004303 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 684738004304 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 684738004305 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 684738004306 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 684738004307 ArsC family; Region: ArsC; pfam03960 684738004308 putative catalytic residues [active] 684738004309 thiol/disulfide switch; other site 684738004310 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 684738004311 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 684738004312 Domain of unknown function (DUF814); Region: DUF814; pfam05670 684738004313 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 684738004314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 684738004315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738004316 S-adenosylmethionine binding site [chemical binding]; other site 684738004317 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 684738004318 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 684738004319 Walker A/P-loop; other site 684738004320 ATP binding site [chemical binding]; other site 684738004321 Q-loop/lid; other site 684738004322 ABC transporter signature motif; other site 684738004323 Walker B; other site 684738004324 D-loop; other site 684738004325 H-loop/switch region; other site 684738004326 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 684738004327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 684738004328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 684738004329 TM-ABC transporter signature motif; other site 684738004330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 684738004331 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 684738004332 TM-ABC transporter signature motif; other site 684738004333 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 684738004334 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 684738004335 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738004336 NAD binding site [chemical binding]; other site 684738004337 dimer interface [polypeptide binding]; other site 684738004338 substrate binding site [chemical binding]; other site 684738004339 pyruvate kinase; Provisional; Region: PRK05826 684738004340 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 684738004341 domain interfaces; other site 684738004342 active site 684738004343 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 684738004344 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 684738004345 active site 684738004346 ADP/pyrophosphate binding site [chemical binding]; other site 684738004347 dimerization interface [polypeptide binding]; other site 684738004348 allosteric effector site; other site 684738004349 fructose-1,6-bisphosphate binding site; other site 684738004350 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 684738004351 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 684738004352 active site 684738004353 dimer interface [polypeptide binding]; other site 684738004354 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 684738004355 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 684738004356 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 684738004357 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 684738004358 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 684738004359 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 684738004360 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 684738004361 active site 684738004362 tetramer interface; other site 684738004363 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 684738004364 trimer interface [polypeptide binding]; other site 684738004365 Predicted membrane protein [Function unknown]; Region: COG4769 684738004366 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 684738004367 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 684738004368 substrate binding pocket [chemical binding]; other site 684738004369 chain length determination region; other site 684738004370 substrate-Mg2+ binding site; other site 684738004371 catalytic residues [active] 684738004372 aspartate-rich region 1; other site 684738004373 active site lid residues [active] 684738004374 aspartate-rich region 2; other site 684738004375 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 684738004376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738004377 S-adenosylmethionine binding site [chemical binding]; other site 684738004378 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 684738004379 active site 684738004380 dimer interface [polypeptide binding]; other site 684738004381 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 684738004382 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 684738004383 heterodimer interface [polypeptide binding]; other site 684738004384 active site 684738004385 FMN binding site [chemical binding]; other site 684738004386 homodimer interface [polypeptide binding]; other site 684738004387 substrate binding site [chemical binding]; other site 684738004388 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 684738004389 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 684738004390 FAD binding pocket [chemical binding]; other site 684738004391 FAD binding motif [chemical binding]; other site 684738004392 phosphate binding motif [ion binding]; other site 684738004393 beta-alpha-beta structure motif; other site 684738004394 NAD binding pocket [chemical binding]; other site 684738004395 Iron coordination center [ion binding]; other site 684738004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738004398 putative substrate translocation pore; other site 684738004399 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 684738004400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738004401 DNA-binding site [nucleotide binding]; DNA binding site 684738004402 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 684738004403 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738004404 beta-galactosidase; Region: BGL; TIGR03356 684738004405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738004406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004407 dimer interface [polypeptide binding]; other site 684738004408 conserved gate region; other site 684738004409 ABC-ATPase subunit interface; other site 684738004410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004411 dimer interface [polypeptide binding]; other site 684738004412 conserved gate region; other site 684738004413 putative PBP binding loops; other site 684738004414 ABC-ATPase subunit interface; other site 684738004415 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 684738004416 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 684738004417 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 684738004418 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 684738004419 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 684738004420 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 684738004421 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 684738004422 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 684738004423 Repair protein; Region: Repair_PSII; pfam04536 684738004424 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 684738004425 pseudouridine synthase; Region: TIGR00093 684738004426 active site 684738004427 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 684738004428 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 684738004429 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 684738004430 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 684738004431 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 684738004432 ATP-grasp domain; Region: ATP-grasp_4; cl17255 684738004433 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 684738004434 IMP binding site; other site 684738004435 dimer interface [polypeptide binding]; other site 684738004436 interdomain contacts; other site 684738004437 partial ornithine binding site; other site 684738004438 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 684738004439 catalytic residues [active] 684738004440 dimer interface [polypeptide binding]; other site 684738004441 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 684738004442 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 684738004443 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 684738004444 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738004445 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 684738004446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738004447 motif II; other site 684738004448 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 684738004449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 684738004450 Hypothetical protein, C-terminal fragment; frameshift 684738004451 Hypothetical protein, N-terminal part; frameshift 684738004452 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 684738004453 TraX protein; Region: TraX; cl05434 684738004454 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 684738004455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738004456 Ligand Binding Site [chemical binding]; other site 684738004457 Protein-tyrosine-phosphatase, C-terminal fragment; 'frameshift, ptp1' 684738004458 Protein-tyrosine-phosphatase, N-terminal fragment; 'frameshift, ptp1' 684738004459 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 684738004460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 684738004461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738004462 Coenzyme A binding pocket [chemical binding]; other site 684738004463 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 684738004464 Low molecular weight phosphatase family; Region: LMWPc; cd00115 684738004465 active site 684738004466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 684738004467 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 684738004468 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 684738004469 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 684738004470 active site 684738004471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738004472 Haemolysin XhlA; Region: XhlA; pfam10779 684738004473 gp58-like protein; Region: Gp58; pfam07902 684738004474 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738004475 Ligand Binding Site [chemical binding]; other site 684738004476 AAA domain; Region: AAA_31; pfam13614 684738004477 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 684738004478 P-loop; other site 684738004479 Magnesium ion binding site [ion binding]; other site 684738004480 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 684738004481 Magnesium ion binding site [ion binding]; other site 684738004482 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 684738004483 Low molecular weight phosphatase family; Region: LMWPc; cd00115 684738004484 active site 684738004485 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 684738004486 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 684738004487 active site 684738004488 phage holin, LL-H family; Region: holin_LLH; TIGR01673 684738004489 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506 684738004490 Phage tail protein; Region: Sipho_tail; pfam05709 684738004491 Phage tail protein; Region: Sipho_tail; cl17486 684738004492 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 684738004493 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 684738004494 N-acetyl-D-glucosamine binding site [chemical binding]; other site 684738004495 catalytic residue [active] 684738004496 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 684738004497 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 684738004498 Phage major tail protein; Region: Phage_tail; pfam04630 684738004499 Protein of unknown function (DUF806); Region: DUF806; pfam05657 684738004500 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 684738004501 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 684738004502 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 684738004503 oligomerization interface [polypeptide binding]; other site 684738004504 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 684738004505 Phage capsid family; Region: Phage_capsid; pfam05065 684738004506 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 684738004507 oligomer interface [polypeptide binding]; other site 684738004508 active site residues [active] 684738004509 Phage-related protein [Function unknown]; Region: COG4695 684738004510 Phage portal protein; Region: Phage_portal; pfam04860 684738004511 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 684738004512 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 684738004513 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 684738004514 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 684738004515 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 684738004516 active site 684738004517 Protein of unknown function (DUF722); Region: DUF722; pfam05263 684738004518 Prophage protein (DUF1660); Region: DUF1660; pfam07874 684738004519 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 684738004520 substrate interaction site [chemical binding]; other site 684738004521 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 684738004522 trimer interface [polypeptide binding]; other site 684738004523 active site 684738004524 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 684738004525 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 684738004526 Protein of unknown function (DUF658); Region: DUF658; pfam04936 684738004527 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 684738004528 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 684738004529 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 684738004530 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 684738004531 RecT family; Region: RecT; pfam03837 684738004532 phosphodiesterase; Provisional; Region: PRK12704 684738004533 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 684738004534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004535 non-specific DNA binding site [nucleotide binding]; other site 684738004536 salt bridge; other site 684738004537 sequence-specific DNA binding site [nucleotide binding]; other site 684738004538 BRO family, N-terminal domain; Region: Bro-N; smart01040 684738004539 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 684738004540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004541 non-specific DNA binding site [nucleotide binding]; other site 684738004542 salt bridge; other site 684738004543 sequence-specific DNA binding site [nucleotide binding]; other site 684738004544 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738004545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004546 non-specific DNA binding site [nucleotide binding]; other site 684738004547 salt bridge; other site 684738004548 sequence-specific DNA binding site [nucleotide binding]; other site 684738004549 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 684738004550 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 684738004551 pentamer interface [polypeptide binding]; other site 684738004552 dodecaamer interface [polypeptide binding]; other site 684738004553 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 684738004554 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 684738004555 Int/Topo IB signature motif; other site 684738004556 putative DNA-binding protein; Validated; Region: PRK00118 684738004557 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 684738004558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738004559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738004560 active site 684738004561 phosphorylation site [posttranslational modification] 684738004562 intermolecular recognition site; other site 684738004563 dimerization interface [polypeptide binding]; other site 684738004564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738004565 DNA binding site [nucleotide binding] 684738004566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738004567 dimer interface [polypeptide binding]; other site 684738004568 phosphorylation site [posttranslational modification] 684738004569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738004570 ATP binding site [chemical binding]; other site 684738004571 Mg2+ binding site [ion binding]; other site 684738004572 G-X-G motif; other site 684738004573 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 684738004574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 684738004575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738004576 DNA-binding site [nucleotide binding]; DNA binding site 684738004577 UTRA domain; Region: UTRA; pfam07702 684738004578 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 684738004579 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 684738004580 ligand binding site [chemical binding]; other site 684738004581 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 684738004582 active site 684738004583 catalytic motif [active] 684738004584 Zn binding site [ion binding]; other site 684738004585 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 684738004586 intersubunit interface [polypeptide binding]; other site 684738004587 active site 684738004588 catalytic residue [active] 684738004589 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 684738004590 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 684738004591 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 684738004592 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 684738004593 Methyltransferase domain; Region: Methyltransf_31; pfam13847 684738004594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738004595 S-adenosylmethionine binding site [chemical binding]; other site 684738004596 pantothenate kinase; Provisional; Region: PRK05439 684738004597 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 684738004598 ATP-binding site [chemical binding]; other site 684738004599 CoA-binding site [chemical binding]; other site 684738004600 Mg2+-binding site [ion binding]; other site 684738004601 Predicted membrane protein [Function unknown]; Region: COG3223 684738004602 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 684738004603 Cation efflux family; Region: Cation_efflux; pfam01545 684738004604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738004605 non-specific DNA binding site [nucleotide binding]; other site 684738004606 salt bridge; other site 684738004607 sequence-specific DNA binding site [nucleotide binding]; other site 684738004608 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 684738004609 ParB-like nuclease domain; Region: ParBc; pfam02195 684738004610 Phosphoadenosine phosphosulfate sulfotransferase, C-terminal fragment; stop codon 684738004611 Phosphoadenosine phosphosulfate sulfotransferase, N-terminal fragment; stop codon 684738004612 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 684738004613 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 684738004614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004615 dimer interface [polypeptide binding]; other site 684738004616 conserved gate region; other site 684738004617 putative PBP binding loops; other site 684738004618 ABC-ATPase subunit interface; other site 684738004619 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 684738004620 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 684738004621 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 684738004622 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 684738004623 Walker A/P-loop; other site 684738004624 ATP binding site [chemical binding]; other site 684738004625 Q-loop/lid; other site 684738004626 ABC transporter signature motif; other site 684738004627 Walker B; other site 684738004628 D-loop; other site 684738004629 H-loop/switch region; other site 684738004630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 684738004631 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 684738004632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738004633 DNA-binding site [nucleotide binding]; DNA binding site 684738004634 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 684738004635 TrkA-C domain; Region: TrkA_C; pfam02080 684738004636 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 684738004637 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 684738004638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738004639 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 684738004640 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 684738004641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738004642 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738004643 beta-galactosidase; Region: BGL; TIGR03356 684738004644 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 684738004645 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 684738004646 active site turn [active] 684738004647 phosphorylation site [posttranslational modification] 684738004648 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 684738004649 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 684738004650 HPr interaction site; other site 684738004651 glycerol kinase (GK) interaction site [polypeptide binding]; other site 684738004652 active site 684738004653 phosphorylation site [posttranslational modification] 684738004654 transcriptional antiterminator BglG; Provisional; Region: PRK09772 684738004655 CAT RNA binding domain; Region: CAT_RBD; pfam03123 684738004656 PRD domain; Region: PRD; pfam00874 684738004657 PRD domain; Region: PRD; pfam00874 684738004658 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 684738004659 substrate binding site [chemical binding]; other site 684738004660 active site 684738004661 catalytic residues [active] 684738004662 heterodimer interface [polypeptide binding]; other site 684738004663 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 684738004664 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 684738004665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738004666 catalytic residue [active] 684738004667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 684738004668 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 684738004669 active site 684738004670 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 684738004671 active site 684738004672 ribulose/triose binding site [chemical binding]; other site 684738004673 phosphate binding site [ion binding]; other site 684738004674 substrate (anthranilate) binding pocket [chemical binding]; other site 684738004675 product (indole) binding pocket [chemical binding]; other site 684738004676 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 684738004677 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 684738004678 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 684738004679 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 684738004680 Glutamine amidotransferase class-I; Region: GATase; pfam00117 684738004681 glutamine binding [chemical binding]; other site 684738004682 catalytic triad [active] 684738004683 anthranilate synthase component I; Provisional; Region: PRK13570 684738004684 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 684738004685 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 684738004686 Predicted membrane protein [Function unknown]; Region: COG3759 684738004687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738004688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738004689 putative DNA binding site [nucleotide binding]; other site 684738004690 putative Zn2+ binding site [ion binding]; other site 684738004691 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 684738004692 dimer interface [polypeptide binding]; other site 684738004693 FMN binding site [chemical binding]; other site 684738004694 Methyltransferase domain; Region: Methyltransf_31; pfam13847 684738004695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738004696 S-adenosylmethionine binding site [chemical binding]; other site 684738004697 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 684738004698 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 684738004699 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 684738004700 metal binding site 2 [ion binding]; metal-binding site 684738004701 putative DNA binding helix; other site 684738004702 metal binding site 1 [ion binding]; metal-binding site 684738004703 dimer interface [polypeptide binding]; other site 684738004704 structural Zn2+ binding site [ion binding]; other site 684738004705 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 684738004706 EamA-like transporter family; Region: EamA; pfam00892 684738004707 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 684738004708 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 684738004709 DNA binding residues [nucleotide binding] 684738004710 putative dimer interface [polypeptide binding]; other site 684738004711 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 684738004712 classical (c) SDRs; Region: SDR_c; cd05233 684738004713 NAD(P) binding site [chemical binding]; other site 684738004714 active site 684738004715 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 684738004716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 684738004717 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 684738004718 Nitrogen regulatory protein P-II; Region: P-II; smart00938 684738004719 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 684738004720 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 684738004721 Walker A/P-loop; other site 684738004722 ATP binding site [chemical binding]; other site 684738004723 Q-loop/lid; other site 684738004724 ABC transporter signature motif; other site 684738004725 Walker B; other site 684738004726 D-loop; other site 684738004727 H-loop/switch region; other site 684738004728 TOBE domain; Region: TOBE_2; pfam08402 684738004729 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 684738004730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004731 dimer interface [polypeptide binding]; other site 684738004732 conserved gate region; other site 684738004733 putative PBP binding loops; other site 684738004734 ABC-ATPase subunit interface; other site 684738004735 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 684738004736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004737 dimer interface [polypeptide binding]; other site 684738004738 conserved gate region; other site 684738004739 putative PBP binding loops; other site 684738004740 ABC-ATPase subunit interface; other site 684738004741 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 684738004742 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 684738004743 inhibitor-cofactor binding pocket; inhibition site 684738004744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738004745 catalytic residue [active] 684738004746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738004747 MarR family; Region: MarR; pfam01047 684738004748 Mg2+ and Co2+ transporter, CorA family, N-terminal fragment; corA4; stop codon 684738004749 Mg2+ and Co2+ transporter, CorA family, C-terminal fragment; corA4; stop codon 684738004750 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 684738004751 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 684738004752 6-Aminohexanoate-dimer hydrolase, C-terminal fragment; stop codon 684738004753 6-Aminohexanoate-dimer hydrolase, N-terminal fragment; stop codon 684738004754 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 684738004755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738004756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004757 dimer interface [polypeptide binding]; other site 684738004758 conserved gate region; other site 684738004759 ABC-ATPase subunit interface; other site 684738004760 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 684738004761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004762 dimer interface [polypeptide binding]; other site 684738004763 conserved gate region; other site 684738004764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 684738004765 ABC-ATPase subunit interface; other site 684738004766 GMP synthase; Reviewed; Region: guaA; PRK00074 684738004767 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 684738004768 AMP/PPi binding site [chemical binding]; other site 684738004769 candidate oxyanion hole; other site 684738004770 catalytic triad [active] 684738004771 potential glutamine specificity residues [chemical binding]; other site 684738004772 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 684738004773 ATP Binding subdomain [chemical binding]; other site 684738004774 Dimerization subdomain; other site 684738004775 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 684738004776 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738004777 nucleotide binding site [chemical binding]; other site 684738004778 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 684738004779 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738004780 nucleotide binding site [chemical binding]; other site 684738004781 butyrate kinase; Provisional; Region: PRK03011 684738004782 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 684738004783 beta-galactosidase; Region: BGL; TIGR03356 684738004784 Predicted integral membrane protein [Function unknown]; Region: COG5578 684738004785 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 684738004786 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 684738004787 putative active site [active] 684738004788 FOG: PKD repeat [General function prediction only]; Region: COG3291 684738004789 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 684738004790 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 684738004791 sugar binding site [chemical binding]; other site 684738004792 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 684738004793 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 684738004794 Ca binding site [ion binding]; other site 684738004795 active site 684738004796 catalytic site [active] 684738004797 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 684738004798 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 684738004799 active site 684738004800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 684738004801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 684738004802 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 684738004803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738004804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004805 dimer interface [polypeptide binding]; other site 684738004806 conserved gate region; other site 684738004807 putative PBP binding loops; other site 684738004808 ABC-ATPase subunit interface; other site 684738004809 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 684738004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738004811 dimer interface [polypeptide binding]; other site 684738004812 conserved gate region; other site 684738004813 putative PBP binding loops; other site 684738004814 ABC-ATPase subunit interface; other site 684738004815 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 684738004816 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 684738004817 active site 684738004818 metal binding site [ion binding]; metal-binding site 684738004819 homodimer interface [polypeptide binding]; other site 684738004820 catalytic site [active] 684738004821 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 684738004822 Uncharacterized conserved protein [Function unknown]; Region: COG3538 684738004823 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 684738004824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738004825 DNA-binding site [nucleotide binding]; DNA binding site 684738004826 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738004827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 684738004828 ligand binding site [chemical binding]; other site 684738004829 dimerization interface [polypeptide binding]; other site 684738004830 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 684738004831 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 684738004832 putative phosphoketolase; Provisional; Region: PRK05261 684738004833 XFP N-terminal domain; Region: XFP_N; pfam09364 684738004834 XFP C-terminal domain; Region: XFP_C; pfam09363 684738004835 L-arabinose isomerase; Provisional; Region: PRK02929 684738004836 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 684738004837 hexamer (dimer of trimers) interface [polypeptide binding]; other site 684738004838 trimer interface [polypeptide binding]; other site 684738004839 substrate binding site [chemical binding]; other site 684738004840 Mn binding site [ion binding]; other site 684738004841 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 684738004842 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 684738004843 intersubunit interface [polypeptide binding]; other site 684738004844 active site 684738004845 Zn2+ binding site [ion binding]; other site 684738004846 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 684738004847 putative N- and C-terminal domain interface [polypeptide binding]; other site 684738004848 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 684738004849 putative active site [active] 684738004850 MgATP binding site [chemical binding]; other site 684738004851 catalytic site [active] 684738004852 metal binding site [ion binding]; metal-binding site 684738004853 putative carbohydrate binding site [chemical binding]; other site 684738004854 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 684738004855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004856 putative substrate translocation pore; other site 684738004857 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 684738004858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004859 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 684738004860 active site 684738004861 galactoside permease; Reviewed; Region: lacY; PRK09528 684738004862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004863 putative substrate translocation pore; other site 684738004864 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 684738004865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738004866 DNA-binding site [nucleotide binding]; DNA binding site 684738004867 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 684738004868 putative dimerization interface [polypeptide binding]; other site 684738004869 putative ligand binding site [chemical binding]; other site 684738004870 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 684738004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004872 putative substrate translocation pore; other site 684738004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004874 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 684738004875 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 684738004876 putative trimer interface [polypeptide binding]; other site 684738004877 putative CoA binding site [chemical binding]; other site 684738004878 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 684738004879 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 684738004880 inhibitor binding site; inhibition site 684738004881 active site 684738004882 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 684738004883 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 684738004884 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 684738004885 active site 684738004886 catalytic residues [active] 684738004887 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 684738004888 N- and C-terminal domain interface [polypeptide binding]; other site 684738004889 D-xylulose kinase; Region: XylB; TIGR01312 684738004890 active site 684738004891 MgATP binding site [chemical binding]; other site 684738004892 catalytic site [active] 684738004893 metal binding site [ion binding]; metal-binding site 684738004894 xylulose binding site [chemical binding]; other site 684738004895 homodimer interface [polypeptide binding]; other site 684738004896 xylose isomerase; Provisional; Region: PRK05474 684738004897 xylose isomerase; Region: xylose_isom_A; TIGR02630 684738004898 Cupin domain; Region: Cupin_2; pfam07883 684738004899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 684738004900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 684738004901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 684738004902 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 684738004903 ATP-grasp domain; Region: ATP-grasp; pfam02222 684738004904 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 684738004905 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 684738004906 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 684738004907 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 684738004908 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 684738004909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738004910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738004911 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 684738004912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738004914 putative substrate translocation pore; other site 684738004915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738004916 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 684738004917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738004918 motif II; other site 684738004919 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 684738004920 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 684738004921 purine monophosphate binding site [chemical binding]; other site 684738004922 dimer interface [polypeptide binding]; other site 684738004923 putative catalytic residues [active] 684738004924 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 684738004925 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 684738004926 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738004927 active site 684738004928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 684738004929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738004930 NAD(P) binding site [chemical binding]; other site 684738004931 active site 684738004932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738004933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738004934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 684738004935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 684738004936 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 684738004937 Walker A/P-loop; other site 684738004938 ATP binding site [chemical binding]; other site 684738004939 Q-loop/lid; other site 684738004940 ABC transporter signature motif; other site 684738004941 Walker B; other site 684738004942 D-loop; other site 684738004943 H-loop/switch region; other site 684738004944 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 684738004945 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 684738004946 active site 684738004947 substrate binding site [chemical binding]; other site 684738004948 cosubstrate binding site; other site 684738004949 catalytic site [active] 684738004950 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 684738004951 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 684738004952 dimerization interface [polypeptide binding]; other site 684738004953 putative ATP binding site [chemical binding]; other site 684738004954 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 684738004955 Clp amino terminal domain; Region: Clp_N; pfam02861 684738004956 Clp amino terminal domain; Region: Clp_N; pfam02861 684738004957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738004958 Walker A motif; other site 684738004959 ATP binding site [chemical binding]; other site 684738004960 Walker B motif; other site 684738004961 arginine finger; other site 684738004962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738004963 Walker A motif; other site 684738004964 ATP binding site [chemical binding]; other site 684738004965 Walker B motif; other site 684738004966 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 684738004967 Hypothetical protein, N-terminal fragment; frameshift 684738004968 Hypothetical protein, middle fragment; frameshift 684738004969 Hypothetical protein, C-terminal fragment; frameshift 684738004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738004971 NAD(P) binding site [chemical binding]; other site 684738004972 active site 684738004973 amidophosphoribosyltransferase; Provisional; Region: PRK07272 684738004974 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 684738004975 active site 684738004976 tetramer interface [polypeptide binding]; other site 684738004977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738004978 active site 684738004979 short chain dehydrogenase; Provisional; Region: PRK06180 684738004980 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 684738004981 NADP binding site [chemical binding]; other site 684738004982 active site 684738004983 steroid binding site; other site 684738004984 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 684738004985 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 684738004986 dimerization interface [polypeptide binding]; other site 684738004987 ATP binding site [chemical binding]; other site 684738004988 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 684738004989 dimerization interface [polypeptide binding]; other site 684738004990 ATP binding site [chemical binding]; other site 684738004991 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 684738004992 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 684738004993 putative active site [active] 684738004994 catalytic triad [active] 684738004995 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 684738004996 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 684738004997 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 684738004998 ATP binding site [chemical binding]; other site 684738004999 active site 684738005000 substrate binding site [chemical binding]; other site 684738005001 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 684738005002 Uncharacterized conserved protein [Function unknown]; Region: COG1359 684738005003 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 684738005004 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 684738005005 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 684738005006 classical (c) SDRs; Region: SDR_c; cd05233 684738005007 NAD(P) binding site [chemical binding]; other site 684738005008 active site 684738005009 putative transporter; Provisional; Region: PRK10504 684738005010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738005011 putative substrate translocation pore; other site 684738005012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738005013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738005014 MarR family; Region: MarR_2; pfam12802 684738005015 thymidylate synthase; Reviewed; Region: thyA; PRK01827 684738005016 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 684738005017 dimerization interface [polypeptide binding]; other site 684738005018 active site 684738005019 Hypothetical protein , C-terminal fragment; frameshift 684738005020 Hypothetical protein , N-terminal fragment; frameshift 684738005021 Hypothetical protein , C-terminal fragment; frameshift 684738005022 Hypothetical protein , N-terminal fragment; frameshift 684738005023 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 684738005024 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 684738005025 catalytic Zn binding site [ion binding]; other site 684738005026 NAD(P) binding site [chemical binding]; other site 684738005027 structural Zn binding site [ion binding]; other site 684738005028 Enterocin A Immunity; Region: EntA_Immun; pfam08951 684738005029 Predicted membrane protein [Function unknown]; Region: COG4905 684738005030 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 684738005031 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 684738005032 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 684738005033 active site 684738005034 FMN binding site [chemical binding]; other site 684738005035 substrate binding site [chemical binding]; other site 684738005036 catalytic residues [active] 684738005037 homodimer interface [polypeptide binding]; other site 684738005038 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 684738005039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 684738005040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 684738005041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 684738005042 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 684738005043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738005044 Walker A/P-loop; other site 684738005045 ATP binding site [chemical binding]; other site 684738005046 Q-loop/lid; other site 684738005047 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738005048 ABC transporter signature motif; other site 684738005049 Walker B; other site 684738005050 D-loop; other site 684738005051 ABC transporter; Region: ABC_tran_2; pfam12848 684738005052 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 684738005053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738005054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738005055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 684738005056 dimerization interface [polypeptide binding]; other site 684738005057 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 684738005058 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 684738005059 putative active site [active] 684738005060 metal binding site [ion binding]; metal-binding site 684738005061 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 684738005062 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 684738005063 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 684738005064 active site 684738005065 NTP binding site [chemical binding]; other site 684738005066 metal binding triad [ion binding]; metal-binding site 684738005067 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 684738005068 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 684738005069 Predicted acetyltransferase [General function prediction only]; Region: COG3981 684738005070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 684738005071 Coenzyme A binding pocket [chemical binding]; other site 684738005072 dihydrodipicolinate reductase; Provisional; Region: PRK00048 684738005073 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 684738005074 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 684738005075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 684738005076 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 684738005077 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 684738005078 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 684738005079 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 684738005080 RimM N-terminal domain; Region: RimM; pfam01782 684738005081 PRC-barrel domain; Region: PRC; pfam05239 684738005082 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 684738005083 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 684738005084 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 684738005085 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 684738005086 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 684738005087 C-terminal domain interface [polypeptide binding]; other site 684738005088 active site 684738005089 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 684738005090 active site 684738005091 N-terminal domain interface [polypeptide binding]; other site 684738005092 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 684738005093 KH domain; Region: KH_4; pfam13083 684738005094 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 684738005095 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 684738005096 homodimer interface [polypeptide binding]; other site 684738005097 catalytic residues [active] 684738005098 NAD binding site [chemical binding]; other site 684738005099 substrate binding pocket [chemical binding]; other site 684738005100 flexible flap; other site 684738005101 putative acyltransferase; Provisional; Region: PRK05790 684738005102 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 684738005103 dimer interface [polypeptide binding]; other site 684738005104 active site 684738005105 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 684738005106 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 684738005107 dimer interface [polypeptide binding]; other site 684738005108 active site 684738005109 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 684738005110 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 684738005111 active site 684738005112 trimer interface [polypeptide binding]; other site 684738005113 allosteric site; other site 684738005114 active site lid [active] 684738005115 hexamer (dimer of trimers) interface [polypeptide binding]; other site 684738005116 Alpha/beta hydrolase , C-terminal fragment; frameshift 684738005117 Alpha/beta hydrolase , N-terminal fragment; frameshift 684738005118 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 684738005119 HTH domain; Region: HTH_11; pfam08279 684738005120 Mga helix-turn-helix domain; Region: Mga; pfam05043 684738005121 PRD domain; Region: PRD; pfam00874 684738005122 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 684738005123 active site 684738005124 phosphorylation site [posttranslational modification] 684738005125 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 684738005126 active site 684738005127 phosphorylation site [posttranslational modification] 684738005128 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 684738005129 active site 684738005130 P-loop; other site 684738005131 phosphorylation site [posttranslational modification] 684738005132 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 684738005133 alpha-mannosidase; Provisional; Region: PRK09819 684738005134 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 684738005135 active site 684738005136 metal binding site [ion binding]; metal-binding site 684738005137 catalytic site [active] 684738005138 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 684738005139 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 684738005140 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 684738005141 active site 684738005142 intersubunit interface [polypeptide binding]; other site 684738005143 catalytic residue [active] 684738005144 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 684738005145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 684738005146 substrate binding site [chemical binding]; other site 684738005147 ATP binding site [chemical binding]; other site 684738005148 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 684738005149 active site 684738005150 catalytic residues [active] 684738005151 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 684738005152 galactarate dehydratase; Region: galactar-dH20; TIGR03248 684738005153 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 684738005154 altronate oxidoreductase; Provisional; Region: PRK03643 684738005155 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 684738005156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 684738005157 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 684738005158 Glucuronate isomerase; Region: UxaC; pfam02614 684738005159 MFS/sugar transport protein; Region: MFS_2; pfam13347 684738005160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738005161 putative substrate translocation pore; other site 684738005162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738005163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738005164 DNA binding site [nucleotide binding] 684738005165 domain linker motif; other site 684738005166 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 684738005167 putative dimerization interface [polypeptide binding]; other site 684738005168 putative ligand binding site [chemical binding]; other site 684738005169 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 684738005170 Hypothetical protein, N-terminal fragment; frameshift 684738005171 Hypothetical protein, C-terminal fragment; frameshift 684738005172 Hypothetical protein, N-terminal fragment; stop codon 684738005173 Hypothetical protein, C-terminal fragment; stop codon 684738005174 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 684738005175 Plasmid replication protein RepRC, N-terminal fragment; frameshift 684738005176 Plasmid replication protein RepRC, C-terminal fragment; frameshift 684738005177 Integrase, N-terminal fragment; frameshift 684738005178 Integrase, C-terminal fragment; frameshift 684738005179 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 684738005180 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 684738005181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738005182 non-specific DNA binding site [nucleotide binding]; other site 684738005183 salt bridge; other site 684738005184 sequence-specific DNA binding site [nucleotide binding]; other site 684738005185 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 684738005186 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 684738005187 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738005188 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738005189 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738005190 WxL domain surface cell wall-binding; Region: WxL; pfam13731 684738005191 GTPase CgtA; Reviewed; Region: obgE; PRK12297 684738005192 GTP1/OBG; Region: GTP1_OBG; pfam01018 684738005193 Obg GTPase; Region: Obg; cd01898 684738005194 G1 box; other site 684738005195 GTP/Mg2+ binding site [chemical binding]; other site 684738005196 Switch I region; other site 684738005197 G2 box; other site 684738005198 G3 box; other site 684738005199 Switch II region; other site 684738005200 G4 box; other site 684738005201 G5 box; other site 684738005202 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 684738005203 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 684738005204 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 684738005205 Cell division protein FtsQ; Region: FtsQ; pfam03799 684738005206 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 684738005207 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 684738005208 homodimer interface [polypeptide binding]; other site 684738005209 active site 684738005210 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 684738005211 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 684738005212 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738005213 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 684738005214 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 684738005215 Nitrogen regulatory protein P-II; Region: P-II; smart00938 684738005216 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 684738005217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738005218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 684738005219 dimerization interface [polypeptide binding]; other site 684738005220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738005221 dimer interface [polypeptide binding]; other site 684738005222 phosphorylation site [posttranslational modification] 684738005223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738005224 ATP binding site [chemical binding]; other site 684738005225 Mg2+ binding site [ion binding]; other site 684738005226 G-X-G motif; other site 684738005227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738005228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738005229 active site 684738005230 phosphorylation site [posttranslational modification] 684738005231 intermolecular recognition site; other site 684738005232 dimerization interface [polypeptide binding]; other site 684738005233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738005234 DNA binding site [nucleotide binding] 684738005235 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 684738005236 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 684738005237 conserved hypothetical protein; Region: TIGR02328 684738005238 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 684738005239 Ser/Thr protein phosphatase family protein, C-terminal fragment; 2 stop codons 684738005240 Ser/Thr protein phosphatase family protein, N-terminal fragment; 2 stop codons 684738005241 Hypothetical protein, C-terminal fragment; frameshift 684738005242 Hypothetical protein, N-terminal fragment; frameshift 684738005243 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 684738005244 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 684738005245 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 684738005246 catalytic site [active] 684738005247 subunit interface [polypeptide binding]; other site 684738005248 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 684738005249 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 684738005250 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 684738005251 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 684738005252 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 684738005253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738005254 active site 684738005255 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 684738005256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738005257 dimerization interface [polypeptide binding]; other site 684738005258 putative DNA binding site [nucleotide binding]; other site 684738005259 putative Zn2+ binding site [ion binding]; other site 684738005260 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 684738005261 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 684738005262 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 684738005263 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 684738005264 putative catalytic cysteine [active] 684738005265 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 684738005266 nucleotide binding site [chemical binding]; other site 684738005267 homotetrameric interface [polypeptide binding]; other site 684738005268 putative phosphate binding site [ion binding]; other site 684738005269 putative allosteric binding site; other site 684738005270 Uncharacterized conserved protein [Function unknown]; Region: COG2461 684738005271 Family of unknown function (DUF438); Region: DUF438; pfam04282 684738005272 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 684738005273 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 684738005274 Predicted membrane protein [Function unknown]; Region: COG4392 684738005275 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 684738005276 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 684738005277 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 684738005278 Spermidine N1-acetyltransferase, N-terminal fragment; stop codon 684738005279 Spermidine N1-acetyltransferase, C-terminal fragment; stop codon 684738005280 signal recognition particle protein; Provisional; Region: PRK10867 684738005281 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 684738005282 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 684738005283 P loop; other site 684738005284 GTP binding site [chemical binding]; other site 684738005285 Signal peptide binding domain; Region: SRP_SPB; pfam02978 684738005286 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 684738005287 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 684738005288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 684738005289 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 684738005290 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 684738005291 MgtC family; Region: MgtC; pfam02308 684738005292 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 684738005293 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 684738005294 dimer interface [polypeptide binding]; other site 684738005295 active site 684738005296 catalytic residue [active] 684738005297 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 684738005298 nudix motif; other site 684738005299 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 684738005300 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 684738005301 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 684738005302 amphipathic channel; other site 684738005303 Asn-Pro-Ala signature motifs; other site 684738005304 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 684738005305 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 684738005306 TPP-binding site [chemical binding]; other site 684738005307 dimer interface [polypeptide binding]; other site 684738005308 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 684738005309 PYR/PP interface [polypeptide binding]; other site 684738005310 dimer interface [polypeptide binding]; other site 684738005311 TPP binding site [chemical binding]; other site 684738005312 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 684738005313 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 684738005314 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 684738005315 active site 684738005316 P-loop; other site 684738005317 phosphorylation site [posttranslational modification] 684738005318 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 684738005319 PRD domain; Region: PRD; pfam00874 684738005320 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 684738005321 active site 684738005322 P-loop; other site 684738005323 phosphorylation site [posttranslational modification] 684738005324 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 684738005325 active site 684738005326 phosphorylation site [posttranslational modification] 684738005327 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 684738005328 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 684738005329 active site 684738005330 intersubunit interface [polypeptide binding]; other site 684738005331 catalytic residue [active] 684738005332 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 684738005333 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 684738005334 substrate binding site [chemical binding]; other site 684738005335 ATP binding site [chemical binding]; other site 684738005336 Glucuronate isomerase; Region: UxaC; pfam02614 684738005337 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 684738005338 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 684738005339 active site 684738005340 catalytic residues [active] 684738005341 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 684738005342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738005343 putative substrate translocation pore; other site 684738005344 mannonate dehydratase; Provisional; Region: PRK03906 684738005345 mannonate dehydratase; Region: uxuA; TIGR00695 684738005346 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 684738005347 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 684738005348 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 684738005349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 684738005350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 684738005351 DNA-binding site [nucleotide binding]; DNA binding site 684738005352 FCD domain; Region: FCD; pfam07729 684738005353 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 684738005354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738005355 putative substrate translocation pore; other site 684738005356 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 684738005357 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 684738005358 ligand binding site [chemical binding]; other site 684738005359 dimerization interface [polypeptide binding]; other site 684738005360 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 684738005361 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 684738005362 TM-ABC transporter signature motif; other site 684738005363 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 684738005364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738005365 Walker A/P-loop; other site 684738005366 ATP binding site [chemical binding]; other site 684738005367 Q-loop/lid; other site 684738005368 ABC transporter signature motif; other site 684738005369 Walker B; other site 684738005370 D-loop; other site 684738005371 H-loop/switch region; other site 684738005372 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 684738005373 D-ribose pyranase; Provisional; Region: PRK11797 684738005374 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 684738005375 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 684738005376 substrate binding site [chemical binding]; other site 684738005377 dimer interface [polypeptide binding]; other site 684738005378 ATP binding site [chemical binding]; other site 684738005379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738005380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738005381 DNA binding site [nucleotide binding] 684738005382 domain linker motif; other site 684738005383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 684738005384 dimerization interface [polypeptide binding]; other site 684738005385 ligand binding site [chemical binding]; other site 684738005386 adenylosuccinate lyase; Provisional; Region: PRK07492 684738005387 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 684738005388 tetramer interface [polypeptide binding]; other site 684738005389 active site 684738005390 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 684738005391 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 684738005392 active site 684738005393 catalytic residue [active] 684738005394 dimer interface [polypeptide binding]; other site 684738005395 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 684738005396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 684738005397 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 684738005398 catalytic residues [active] 684738005399 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 684738005400 MutS domain III; Region: MutS_III; pfam05192 684738005401 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 684738005402 Walker A/P-loop; other site 684738005403 ATP binding site [chemical binding]; other site 684738005404 Q-loop/lid; other site 684738005405 ABC transporter signature motif; other site 684738005406 Walker B; other site 684738005407 D-loop; other site 684738005408 H-loop/switch region; other site 684738005409 Smr domain; Region: Smr; pfam01713 684738005410 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 684738005411 Colicin V production protein; Region: Colicin_V; pfam02674 684738005412 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 684738005413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738005414 catabolite control protein A; Region: ccpA; TIGR01481 684738005415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738005416 DNA binding site [nucleotide binding] 684738005417 domain linker motif; other site 684738005418 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 684738005419 dimerization interface [polypeptide binding]; other site 684738005420 effector binding site; other site 684738005421 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 684738005422 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 684738005423 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 684738005424 active site 684738005425 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 684738005426 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 684738005427 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 684738005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 684738005429 cell division protein GpsB; Provisional; Region: PRK14127 684738005430 DivIVA domain; Region: DivI1A_domain; TIGR03544 684738005431 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 684738005432 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 684738005433 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 684738005434 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 684738005435 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 684738005436 Hydrolase, HAD superfamily, N-terminal fragment; frameshift 684738005437 Hydrolase, HAD superfamily, C-terminal fragment; frameshift 684738005438 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 684738005439 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 684738005440 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 684738005441 ATP-binding site [chemical binding]; other site 684738005442 Sugar specificity; other site 684738005443 Pyrimidine base specificity; other site 684738005444 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 684738005445 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 684738005446 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 684738005447 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 684738005448 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 684738005449 UbiA prenyltransferase family; Region: UbiA; pfam01040 684738005450 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 684738005451 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 684738005452 Cl- selectivity filter; other site 684738005453 Cl- binding residues [ion binding]; other site 684738005454 pore gating glutamate residue; other site 684738005455 dimer interface [polypeptide binding]; other site 684738005456 H+/Cl- coupling transport residue; other site 684738005457 TrkA-C domain; Region: TrkA_C; pfam02080 684738005458 Enterocin A Immunity; Region: EntA_Immun; pfam08951 684738005459 Lactococcin-like family; Region: Lactococcin; pfam04369 684738005460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738005461 non-specific DNA binding site [nucleotide binding]; other site 684738005462 salt bridge; other site 684738005463 sequence-specific DNA binding site [nucleotide binding]; other site 684738005464 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738005465 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 684738005466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738005467 S-adenosylmethionine binding site [chemical binding]; other site 684738005468 Predicted membrane protein [Function unknown]; Region: COG1511 684738005469 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 684738005470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 684738005471 dimer interface [polypeptide binding]; other site 684738005472 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 684738005473 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 684738005474 beta-galactosidase; Region: BGL; TIGR03356 684738005475 Uncharacterized conserved protein [Function unknown]; Region: COG0759 684738005476 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 684738005477 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 684738005478 TPP-binding site; other site 684738005479 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 684738005480 PYR/PP interface [polypeptide binding]; other site 684738005481 dimer interface [polypeptide binding]; other site 684738005482 TPP binding site [chemical binding]; other site 684738005483 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 684738005484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738005485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 684738005486 dimer interface [polypeptide binding]; other site 684738005487 phosphorylation site [posttranslational modification] 684738005488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738005489 ATP binding site [chemical binding]; other site 684738005490 Mg2+ binding site [ion binding]; other site 684738005491 G-X-G motif; other site 684738005492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738005493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738005494 active site 684738005495 phosphorylation site [posttranslational modification] 684738005496 intermolecular recognition site; other site 684738005497 dimerization interface [polypeptide binding]; other site 684738005498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738005499 DNA binding site [nucleotide binding] 684738005500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738005501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738005502 DNA binding site [nucleotide binding] 684738005503 domain linker motif; other site 684738005504 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 684738005505 putative dimerization interface [polypeptide binding]; other site 684738005506 putative ligand binding site [chemical binding]; other site 684738005507 maltose phosphorylase; Provisional; Region: PRK13807 684738005508 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 684738005509 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 684738005510 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 684738005511 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 684738005512 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 684738005513 Ca binding site [ion binding]; other site 684738005514 active site 684738005515 catalytic site [active] 684738005516 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 684738005517 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 684738005518 Ca binding site [ion binding]; other site 684738005519 active site 684738005520 catalytic site [active] 684738005521 maltose O-acetyltransferase; Provisional; Region: PRK10092 684738005522 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 684738005523 active site 684738005524 substrate binding site [chemical binding]; other site 684738005525 trimer interface [polypeptide binding]; other site 684738005526 CoA binding site [chemical binding]; other site 684738005527 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 684738005528 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 684738005529 Ca binding site [ion binding]; other site 684738005530 active site 684738005531 catalytic site [active] 684738005532 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 684738005533 homodimer interface [polypeptide binding]; other site 684738005534 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 684738005535 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 684738005536 active site 684738005537 homodimer interface [polypeptide binding]; other site 684738005538 catalytic site [active] 684738005539 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 684738005540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 684738005541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005542 dimer interface [polypeptide binding]; other site 684738005543 conserved gate region; other site 684738005544 putative PBP binding loops; other site 684738005545 ABC-ATPase subunit interface; other site 684738005546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005548 dimer interface [polypeptide binding]; other site 684738005549 conserved gate region; other site 684738005550 putative PBP binding loops; other site 684738005551 ABC-ATPase subunit interface; other site 684738005552 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 684738005553 Enterocin A Immunity; Region: EntA_Immun; pfam08951 684738005554 LssY C-terminus; Region: LssY_C; pfam14067 684738005555 Hypothetical protein, extracellular, N-terminal fragment 684738005556 Hypothetical protein, extracellular, LPXTG-anchored, C-terminal fragment 684738005557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738005558 dimerization interface [polypeptide binding]; other site 684738005559 putative DNA binding site [nucleotide binding]; other site 684738005560 putative Zn2+ binding site [ion binding]; other site 684738005561 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 684738005562 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 684738005563 putative active site [active] 684738005564 putative FMN binding site [chemical binding]; other site 684738005565 putative substrate binding site [chemical binding]; other site 684738005566 putative catalytic residue [active] 684738005567 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 684738005568 CAAX protease self-immunity; Region: Abi; pfam02517 684738005569 Transcriptional regulator [Transcription]; Region: LytR; COG1316 684738005570 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738005571 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 684738005572 Walker A/P-loop; other site 684738005573 ATP binding site [chemical binding]; other site 684738005574 Q-loop/lid; other site 684738005575 ABC transporter signature motif; other site 684738005576 Walker B; other site 684738005577 D-loop; other site 684738005578 H-loop/switch region; other site 684738005579 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 684738005580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005581 dimer interface [polypeptide binding]; other site 684738005582 conserved gate region; other site 684738005583 putative PBP binding loops; other site 684738005584 ABC-ATPase subunit interface; other site 684738005585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005586 dimer interface [polypeptide binding]; other site 684738005587 conserved gate region; other site 684738005588 ABC-ATPase subunit interface; other site 684738005589 carbamate kinase; Reviewed; Region: PRK12686 684738005590 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 684738005591 putative substrate binding site [chemical binding]; other site 684738005592 nucleotide binding site [chemical binding]; other site 684738005593 nucleotide binding site [chemical binding]; other site 684738005594 homodimer interface [polypeptide binding]; other site 684738005595 agmatine deiminase; Provisional; Region: PRK13551 684738005596 agmatine deiminase; Region: agmatine_aguA; TIGR03380 684738005597 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 684738005598 putrescine carbamoyltransferase; Provisional; Region: PRK02255 684738005599 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 684738005600 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 684738005601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 684738005602 DNA binding residues [nucleotide binding] 684738005603 dimerization interface [polypeptide binding]; other site 684738005604 Transcriptional regulator [Transcription]; Region: LytR; COG1316 684738005605 cytidylate kinase; Provisional; Region: cmk; PRK00023 684738005606 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 684738005607 CMP-binding site; other site 684738005608 The sites determining sugar specificity; other site 684738005609 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 684738005610 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 684738005611 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 684738005612 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 684738005613 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 684738005614 active pocket/dimerization site; other site 684738005615 active site 684738005616 phosphorylation site [posttranslational modification] 684738005617 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 684738005618 active site 684738005619 phosphorylation site [posttranslational modification] 684738005620 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 684738005621 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 684738005622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 684738005623 Uncharacterized conserved protein [Function unknown]; Region: COG1284 684738005624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 684738005625 seryl-tRNA synthetase; Provisional; Region: PRK05431 684738005626 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 684738005627 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 684738005628 dimer interface [polypeptide binding]; other site 684738005629 active site 684738005630 motif 1; other site 684738005631 motif 2; other site 684738005632 motif 3; other site 684738005633 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 684738005634 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 684738005635 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 684738005636 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738005637 Walker A/P-loop; other site 684738005638 ATP binding site [chemical binding]; other site 684738005639 Q-loop/lid; other site 684738005640 ABC transporter signature motif; other site 684738005641 Walker B; other site 684738005642 D-loop; other site 684738005643 H-loop/switch region; other site 684738005644 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 684738005645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738005646 FeS/SAM binding site; other site 684738005647 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 684738005648 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 684738005649 putative dimer interface [polypeptide binding]; other site 684738005650 catalytic triad [active] 684738005651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738005652 catalytic core [active] 684738005653 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 684738005654 PhoU domain; Region: PhoU; pfam01895 684738005655 PhoU domain; Region: PhoU; pfam01895 684738005656 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 684738005657 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 684738005658 Walker A/P-loop; other site 684738005659 ATP binding site [chemical binding]; other site 684738005660 Q-loop/lid; other site 684738005661 ABC transporter signature motif; other site 684738005662 Walker B; other site 684738005663 D-loop; other site 684738005664 H-loop/switch region; other site 684738005665 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 684738005666 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 684738005667 Walker A/P-loop; other site 684738005668 ATP binding site [chemical binding]; other site 684738005669 Q-loop/lid; other site 684738005670 ABC transporter signature motif; other site 684738005671 Walker B; other site 684738005672 D-loop; other site 684738005673 H-loop/switch region; other site 684738005674 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 684738005675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005676 dimer interface [polypeptide binding]; other site 684738005677 conserved gate region; other site 684738005678 putative PBP binding loops; other site 684738005679 ABC-ATPase subunit interface; other site 684738005680 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 684738005681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005682 dimer interface [polypeptide binding]; other site 684738005683 conserved gate region; other site 684738005684 putative PBP binding loops; other site 684738005685 ABC-ATPase subunit interface; other site 684738005686 PBP superfamily domain; Region: PBP_like_2; cl17296 684738005687 PBP superfamily domain; Region: PBP_like_2; cl17296 684738005688 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 684738005689 SmpB-tmRNA interface; other site 684738005690 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 684738005691 catalytic triad [active] 684738005692 oxyanion hole [active] 684738005693 active site 684738005694 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 684738005695 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 684738005696 motif 1; other site 684738005697 active site 684738005698 motif 2; other site 684738005699 motif 3; other site 684738005700 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 684738005701 DHHA1 domain; Region: DHHA1; pfam02272 684738005702 foldase protein PrsA; Reviewed; Region: PRK12450 684738005703 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 684738005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738005705 S-adenosylmethionine binding site [chemical binding]; other site 684738005706 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 684738005707 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 684738005708 active site 684738005709 Zn binding site [ion binding]; other site 684738005710 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 684738005711 Uncharacterized conserved protein [Function unknown]; Region: COG1434 684738005712 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 684738005713 putative active site [active] 684738005714 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 684738005715 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 684738005716 Sulfate transporter family; Region: Sulfate_transp; pfam00916 684738005717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738005718 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 684738005719 active site 684738005720 motif I; other site 684738005721 motif II; other site 684738005722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 684738005723 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 684738005724 Cysteine-rich domain; Region: CCG; pfam02754 684738005725 Cysteine-rich domain; Region: CCG; pfam02754 684738005726 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 684738005727 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 684738005728 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 684738005729 Uncharacterized conserved protein [Function unknown]; Region: COG1556 684738005730 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 684738005731 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 684738005732 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 684738005733 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 684738005734 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 684738005735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738005736 Zn2+ binding site [ion binding]; other site 684738005737 Mg2+ binding site [ion binding]; other site 684738005738 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 684738005739 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 684738005740 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 684738005741 AAA domain; Region: AAA_30; pfam13604 684738005742 Family description; Region: UvrD_C_2; pfam13538 684738005743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738005744 catalytic core [active] 684738005745 prephenate dehydratase; Provisional; Region: PRK11898 684738005746 Prephenate dehydratase; Region: PDT; pfam00800 684738005747 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 684738005748 putative L-Phe binding site [chemical binding]; other site 684738005749 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 684738005750 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 684738005751 ADP binding site [chemical binding]; other site 684738005752 magnesium binding site [ion binding]; other site 684738005753 putative shikimate binding site; other site 684738005754 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 684738005755 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 684738005756 hinge; other site 684738005757 active site 684738005758 prephenate dehydrogenase; Validated; Region: PRK06545 684738005759 prephenate dehydrogenase; Validated; Region: PRK08507 684738005760 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 684738005761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 684738005762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738005763 ATP binding site [chemical binding]; other site 684738005764 Mg2+ binding site [ion binding]; other site 684738005765 G-X-G motif; other site 684738005766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 684738005767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 684738005768 active site 684738005769 phosphorylation site [posttranslational modification] 684738005770 intermolecular recognition site; other site 684738005771 dimerization interface [polypeptide binding]; other site 684738005772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 684738005773 DNA binding site [nucleotide binding] 684738005774 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 684738005775 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738005776 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738005777 Walker A/P-loop; other site 684738005778 ATP binding site [chemical binding]; other site 684738005779 Q-loop/lid; other site 684738005780 ABC transporter signature motif; other site 684738005781 Walker B; other site 684738005782 D-loop; other site 684738005783 H-loop/switch region; other site 684738005784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 684738005785 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 684738005786 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 684738005787 Tetramer interface [polypeptide binding]; other site 684738005788 active site 684738005789 FMN-binding site [chemical binding]; other site 684738005790 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 684738005791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738005792 active site 684738005793 motif I; other site 684738005794 motif II; other site 684738005795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 684738005796 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 684738005797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 684738005798 Protein of unknown function, DUF606; Region: DUF606; pfam04657 684738005799 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 684738005800 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 684738005801 active site 684738005802 dimer interface [polypeptide binding]; other site 684738005803 metal binding site [ion binding]; metal-binding site 684738005804 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 684738005805 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 684738005806 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 684738005807 shikimate binding site; other site 684738005808 NAD(P) binding site [chemical binding]; other site 684738005809 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 684738005810 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 684738005811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 684738005812 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 684738005813 substrate binding pocket [chemical binding]; other site 684738005814 membrane-bound complex binding site; other site 684738005815 hinge residues; other site 684738005816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 684738005817 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 684738005818 substrate binding pocket [chemical binding]; other site 684738005819 membrane-bound complex binding site; other site 684738005820 hinge residues; other site 684738005821 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 684738005822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005823 dimer interface [polypeptide binding]; other site 684738005824 conserved gate region; other site 684738005825 putative PBP binding loops; other site 684738005826 ABC-ATPase subunit interface; other site 684738005827 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 684738005828 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 684738005829 Walker A/P-loop; other site 684738005830 ATP binding site [chemical binding]; other site 684738005831 Q-loop/lid; other site 684738005832 ABC transporter signature motif; other site 684738005833 Walker B; other site 684738005834 D-loop; other site 684738005835 H-loop/switch region; other site 684738005836 legume lectins; Region: lectin_L-type; cl14058 684738005837 homotetramer interaction site [polypeptide binding]; other site 684738005838 carbohydrate binding site [chemical binding]; other site 684738005839 metal binding site [ion binding]; metal-binding site 684738005840 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 684738005841 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 684738005842 gamma subunit interface [polypeptide binding]; other site 684738005843 epsilon subunit interface [polypeptide binding]; other site 684738005844 LBP interface [polypeptide binding]; other site 684738005845 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 684738005846 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 684738005847 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 684738005848 alpha subunit interaction interface [polypeptide binding]; other site 684738005849 Walker A motif; other site 684738005850 ATP binding site [chemical binding]; other site 684738005851 Walker B motif; other site 684738005852 inhibitor binding site; inhibition site 684738005853 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 684738005854 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 684738005855 core domain interface [polypeptide binding]; other site 684738005856 delta subunit interface [polypeptide binding]; other site 684738005857 epsilon subunit interface [polypeptide binding]; other site 684738005858 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 684738005859 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 684738005860 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 684738005861 beta subunit interaction interface [polypeptide binding]; other site 684738005862 Walker A motif; other site 684738005863 ATP binding site [chemical binding]; other site 684738005864 Walker B motif; other site 684738005865 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 684738005866 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 684738005867 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 684738005868 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 684738005869 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 684738005870 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 684738005871 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 684738005872 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 684738005873 Predicted esterase [General function prediction only]; Region: COG0627 684738005874 S-formylglutathione hydrolase; Region: PLN02442 684738005875 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 684738005876 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 684738005877 Competence protein; Region: Competence; pfam03772 684738005878 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 684738005879 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 684738005880 SLBB domain; Region: SLBB; pfam10531 684738005881 comEA protein; Region: comE; TIGR01259 684738005882 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 684738005883 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 684738005884 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 684738005885 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 684738005886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738005887 Walker A/P-loop; other site 684738005888 ATP binding site [chemical binding]; other site 684738005889 Q-loop/lid; other site 684738005890 ABC transporter signature motif; other site 684738005891 Walker B; other site 684738005892 D-loop; other site 684738005893 H-loop/switch region; other site 684738005894 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 684738005895 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 684738005896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738005897 Coenzyme A binding pocket [chemical binding]; other site 684738005898 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 684738005899 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 684738005900 transmembrane helices; other site 684738005901 Putative transcription activator [Transcription]; Region: TenA; COG0819 684738005902 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 684738005903 CHY zinc finger; Region: zf-CHY; pfam05495 684738005904 Biotin operon repressor [Transcription]; Region: BirA; COG1654 684738005905 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 684738005906 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 684738005907 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 684738005908 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 684738005909 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 684738005910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 684738005911 acyl-activating enzyme (AAE) consensus motif; other site 684738005912 AMP binding site [chemical binding]; other site 684738005913 active site 684738005914 CoA binding site [chemical binding]; other site 684738005915 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 684738005916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 684738005917 dimer interface [polypeptide binding]; other site 684738005918 active site 684738005919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 684738005920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738005921 NAD(P) binding site [chemical binding]; other site 684738005922 active site 684738005923 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 684738005924 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 684738005925 FMN binding site [chemical binding]; other site 684738005926 substrate binding site [chemical binding]; other site 684738005927 putative catalytic residue [active] 684738005928 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 684738005929 FeS assembly protein SufB; Region: sufB; TIGR01980 684738005930 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 684738005931 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 684738005932 trimerization site [polypeptide binding]; other site 684738005933 active site 684738005934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 684738005935 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 684738005936 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 684738005937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 684738005938 catalytic residue [active] 684738005939 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 684738005940 FeS assembly protein SufD; Region: sufD; TIGR01981 684738005941 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 684738005942 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 684738005943 Walker A/P-loop; other site 684738005944 ATP binding site [chemical binding]; other site 684738005945 Q-loop/lid; other site 684738005946 ABC transporter signature motif; other site 684738005947 Walker B; other site 684738005948 D-loop; other site 684738005949 H-loop/switch region; other site 684738005950 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 684738005951 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 684738005952 Mg++ binding site [ion binding]; other site 684738005953 putative catalytic motif [active] 684738005954 substrate binding site [chemical binding]; other site 684738005955 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 684738005956 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 684738005957 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 684738005958 Walker A/P-loop; other site 684738005959 ATP binding site [chemical binding]; other site 684738005960 Q-loop/lid; other site 684738005961 ABC transporter signature motif; other site 684738005962 Walker B; other site 684738005963 D-loop; other site 684738005964 H-loop/switch region; other site 684738005965 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 684738005966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738005967 dimer interface [polypeptide binding]; other site 684738005968 conserved gate region; other site 684738005969 putative PBP binding loops; other site 684738005970 ABC-ATPase subunit interface; other site 684738005971 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 684738005972 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 684738005973 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 684738005974 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 684738005975 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 684738005976 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 684738005977 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 684738005978 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 684738005979 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 684738005980 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 684738005981 G-loop; other site 684738005982 DNA binding site [nucleotide binding] 684738005983 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 684738005984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 684738005985 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 684738005986 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 684738005987 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 684738005988 RPB1 interaction site [polypeptide binding]; other site 684738005989 RPB10 interaction site [polypeptide binding]; other site 684738005990 RPB11 interaction site [polypeptide binding]; other site 684738005991 RPB3 interaction site [polypeptide binding]; other site 684738005992 RPB12 interaction site [polypeptide binding]; other site 684738005993 CodY GAF-like domain; Region: CodY; pfam06018 684738005994 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738005995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738005996 non-specific DNA binding site [nucleotide binding]; other site 684738005997 salt bridge; other site 684738005998 sequence-specific DNA binding site [nucleotide binding]; other site 684738005999 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 684738006000 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 684738006001 active site 684738006002 Zn binding site [ion binding]; other site 684738006003 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 684738006004 active site 684738006005 DNA binding site [nucleotide binding] 684738006006 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 684738006007 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 684738006008 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 684738006009 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 684738006010 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738006011 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 684738006012 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 684738006013 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 684738006014 NAD binding site [chemical binding]; other site 684738006015 substrate binding site [chemical binding]; other site 684738006016 catalytic Zn binding site [ion binding]; other site 684738006017 tetramer interface [polypeptide binding]; other site 684738006018 structural Zn binding site [ion binding]; other site 684738006019 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 684738006020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738006021 ATP binding site [chemical binding]; other site 684738006022 putative Mg++ binding site [ion binding]; other site 684738006023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738006024 nucleotide binding region [chemical binding]; other site 684738006025 ATP-binding site [chemical binding]; other site 684738006026 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 684738006027 HRDC domain; Region: HRDC; pfam00570 684738006028 inner membrane transporter YjeM; Provisional; Region: PRK15238 684738006029 peptidase T; Region: peptidase-T; TIGR01882 684738006030 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 684738006031 metal binding site [ion binding]; metal-binding site 684738006032 dimer interface [polypeptide binding]; other site 684738006033 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 684738006034 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 684738006035 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 684738006036 DHH family; Region: DHH; pfam01368 684738006037 DHHA2 domain; Region: DHHA2; pfam02833 684738006038 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 684738006039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738006040 FeS/SAM binding site; other site 684738006041 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 684738006042 Domain of unknown function DUF21; Region: DUF21; pfam01595 684738006043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 684738006044 Transporter associated domain; Region: CorC_HlyC; smart01091 684738006045 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 684738006046 Domain of unknown function DUF20; Region: UPF0118; pfam01594 684738006047 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 684738006048 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 684738006049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738006050 non-specific DNA binding site [nucleotide binding]; other site 684738006051 salt bridge; other site 684738006052 sequence-specific DNA binding site [nucleotide binding]; other site 684738006053 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 684738006054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 684738006055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738006056 Coenzyme A binding pocket [chemical binding]; other site 684738006057 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 684738006058 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 684738006059 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 684738006060 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738006061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738006062 non-specific DNA binding site [nucleotide binding]; other site 684738006063 salt bridge; other site 684738006064 sequence-specific DNA binding site [nucleotide binding]; other site 684738006065 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 684738006066 Int/Topo IB signature motif; other site 684738006067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 684738006068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738006069 Coenzyme A binding pocket [chemical binding]; other site 684738006070 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 684738006071 putative uracil binding site [chemical binding]; other site 684738006072 putative active site [active] 684738006073 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 684738006074 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 684738006075 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 684738006076 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 684738006077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 684738006078 catalytic core [active] 684738006079 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 684738006080 GIY-YIG motif/motif A; other site 684738006081 putative active site [active] 684738006082 putative metal binding site [ion binding]; other site 684738006083 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 684738006084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 684738006085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 684738006086 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 684738006087 Thiamine pyrophosphokinase; Region: TPK; cd07995 684738006088 active site 684738006089 dimerization interface [polypeptide binding]; other site 684738006090 thiamine binding site [chemical binding]; other site 684738006091 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 684738006092 putative metal binding site [ion binding]; other site 684738006093 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 684738006094 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 684738006095 putative dimer interface [polypeptide binding]; other site 684738006096 putative anticodon binding site; other site 684738006097 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 684738006098 homodimer interface [polypeptide binding]; other site 684738006099 motif 1; other site 684738006100 motif 2; other site 684738006101 active site 684738006102 motif 3; other site 684738006103 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 684738006104 GIY-YIG motif/motif A; other site 684738006105 active site 684738006106 catalytic site [active] 684738006107 metal binding site [ion binding]; metal-binding site 684738006108 aspartate aminotransferase; Provisional; Region: PRK05764 684738006109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738006110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738006111 homodimer interface [polypeptide binding]; other site 684738006112 catalytic residue [active] 684738006113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 684738006114 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 684738006115 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 684738006116 active site 684738006117 catalytic site [active] 684738006118 substrate binding site [chemical binding]; other site 684738006119 DEAD/DEAH box helicase; Region: DEAD; pfam00270 684738006120 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 684738006121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738006122 Ligand Binding Site [chemical binding]; other site 684738006123 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 684738006124 Domain of unknown function DUF21; Region: DUF21; pfam01595 684738006125 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 684738006126 Transporter associated domain; Region: CorC_HlyC; smart01091 684738006127 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 684738006128 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 684738006129 active site 684738006130 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 684738006131 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 684738006132 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 684738006133 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 684738006134 peptide binding site [polypeptide binding]; other site 684738006135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 684738006136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738006137 dimer interface [polypeptide binding]; other site 684738006138 conserved gate region; other site 684738006139 putative PBP binding loops; other site 684738006140 ABC-ATPase subunit interface; other site 684738006141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 684738006142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738006143 dimer interface [polypeptide binding]; other site 684738006144 conserved gate region; other site 684738006145 putative PBP binding loops; other site 684738006146 ABC-ATPase subunit interface; other site 684738006147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 684738006148 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 684738006149 Walker A/P-loop; other site 684738006150 ATP binding site [chemical binding]; other site 684738006151 Q-loop/lid; other site 684738006152 ABC transporter signature motif; other site 684738006153 Walker B; other site 684738006154 D-loop; other site 684738006155 H-loop/switch region; other site 684738006156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 684738006157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 684738006158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 684738006159 Walker A/P-loop; other site 684738006160 ATP binding site [chemical binding]; other site 684738006161 Q-loop/lid; other site 684738006162 ABC transporter signature motif; other site 684738006163 Walker B; other site 684738006164 D-loop; other site 684738006165 H-loop/switch region; other site 684738006166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 684738006167 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 684738006168 23S rRNA binding site [nucleotide binding]; other site 684738006169 L21 binding site [polypeptide binding]; other site 684738006170 L13 binding site [polypeptide binding]; other site 684738006171 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 684738006172 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 684738006173 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 684738006174 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 684738006175 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 684738006176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738006177 motif II; other site 684738006178 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 684738006179 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 684738006180 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 684738006181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 684738006182 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 684738006183 active site 684738006184 metal binding site [ion binding]; metal-binding site 684738006185 dimerization interface [polypeptide binding]; other site 684738006186 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 684738006187 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 684738006188 active site 684738006189 HIGH motif; other site 684738006190 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 684738006191 KMSKS motif; other site 684738006192 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 684738006193 tRNA binding surface [nucleotide binding]; other site 684738006194 anticodon binding site; other site 684738006195 Predicted integral membrane protein [Function unknown]; Region: COG3548 684738006196 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 684738006197 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 684738006198 trimer interface [polypeptide binding]; other site 684738006199 active site 684738006200 substrate binding site [chemical binding]; other site 684738006201 CoA binding site [chemical binding]; other site 684738006202 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 684738006203 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 684738006204 RNase E interface [polypeptide binding]; other site 684738006205 trimer interface [polypeptide binding]; other site 684738006206 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 684738006207 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 684738006208 RNase E interface [polypeptide binding]; other site 684738006209 trimer interface [polypeptide binding]; other site 684738006210 active site 684738006211 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 684738006212 putative nucleic acid binding region [nucleotide binding]; other site 684738006213 G-X-X-G motif; other site 684738006214 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 684738006215 RNA binding site [nucleotide binding]; other site 684738006216 domain interface; other site 684738006217 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 684738006218 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 684738006219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738006220 active site 684738006221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738006222 Ligand Binding Site [chemical binding]; other site 684738006223 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 684738006224 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 684738006225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 684738006226 catalytic residue [active] 684738006227 Putative amino acid metabolism; Region: DUF1831; pfam08866 684738006228 elongation factor Tu; Reviewed; Region: PRK00049 684738006229 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 684738006230 G1 box; other site 684738006231 GEF interaction site [polypeptide binding]; other site 684738006232 GTP/Mg2+ binding site [chemical binding]; other site 684738006233 Switch I region; other site 684738006234 G2 box; other site 684738006235 G3 box; other site 684738006236 Switch II region; other site 684738006237 G4 box; other site 684738006238 G5 box; other site 684738006239 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 684738006240 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 684738006241 Antibiotic Binding Site [chemical binding]; other site 684738006242 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 684738006243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738006244 active site 684738006245 HIGH motif; other site 684738006246 nucleotide binding site [chemical binding]; other site 684738006247 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 684738006248 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 684738006249 active site 684738006250 KMSKS motif; other site 684738006251 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 684738006252 tRNA binding surface [nucleotide binding]; other site 684738006253 anticodon binding site; other site 684738006254 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 684738006255 DivIVA protein; Region: DivIVA; pfam05103 684738006256 DivIVA domain; Region: DivI1A_domain; TIGR03544 684738006257 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 684738006258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 684738006259 YGGT family; Region: YGGT; pfam02325 684738006260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 684738006261 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 684738006262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 684738006263 catalytic residue [active] 684738006264 cell division protein FtsZ; Validated; Region: PRK09330 684738006265 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 684738006266 nucleotide binding site [chemical binding]; other site 684738006267 SulA interaction site; other site 684738006268 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 684738006269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738006270 nucleotide binding site [chemical binding]; other site 684738006271 Cell division protein FtsA; Region: FtsA; pfam14450 684738006272 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 684738006273 EDD domain protein, DegV family; Region: DegV; TIGR00762 684738006274 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 684738006275 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 684738006276 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 684738006277 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 684738006278 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 684738006279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 684738006280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 684738006281 active site 684738006282 catalytic tetrad [active] 684738006283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738006284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738006285 putative substrate translocation pore; other site 684738006286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 684738006287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 684738006288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 684738006289 dimerization interface [polypeptide binding]; other site 684738006290 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 684738006291 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 684738006292 DNA binding residues [nucleotide binding] 684738006293 putative dimer interface [polypeptide binding]; other site 684738006294 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 684738006295 trimer interface [polypeptide binding]; other site 684738006296 active site 684738006297 G bulge; other site 684738006298 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738006299 Zn2+ binding site [ion binding]; other site 684738006300 Mg2+ binding site [ion binding]; other site 684738006301 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 684738006302 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 684738006303 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 684738006304 dimer interface [polypeptide binding]; other site 684738006305 ADP-ribose binding site [chemical binding]; other site 684738006306 active site 684738006307 nudix motif; other site 684738006308 metal binding site [ion binding]; metal-binding site 684738006309 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 684738006310 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 684738006311 Substrate binding site; other site 684738006312 Mg++ binding site; other site 684738006313 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 684738006314 active site 684738006315 substrate binding site [chemical binding]; other site 684738006316 CoA binding site [chemical binding]; other site 684738006317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 684738006318 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 684738006319 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 684738006320 16S/18S rRNA binding site [nucleotide binding]; other site 684738006321 S13e-L30e interaction site [polypeptide binding]; other site 684738006322 25S rRNA binding site [nucleotide binding]; other site 684738006323 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 684738006324 Catalytic domain of Protein Kinases; Region: PKc; cd00180 684738006325 active site 684738006326 ATP binding site [chemical binding]; other site 684738006327 substrate binding site [chemical binding]; other site 684738006328 activation loop (A-loop); other site 684738006329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 684738006330 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 684738006331 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 684738006332 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 684738006333 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 684738006334 active site 684738006335 16S rRNA methyltransferase B; Provisional; Region: PRK14902 684738006336 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 684738006337 putative RNA binding site [nucleotide binding]; other site 684738006338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738006339 S-adenosylmethionine binding site [chemical binding]; other site 684738006340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 684738006341 Predicted membrane protein [Function unknown]; Region: COG2261 684738006342 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 684738006343 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 684738006344 putative active site [active] 684738006345 substrate binding site [chemical binding]; other site 684738006346 putative cosubstrate binding site; other site 684738006347 catalytic site [active] 684738006348 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 684738006349 substrate binding site [chemical binding]; other site 684738006350 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 684738006351 dimer interface [polypeptide binding]; other site 684738006352 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 684738006353 nudix motif; other site 684738006354 SnoaL-like domain; Region: SnoaL_2; pfam12680 684738006355 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 684738006356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738006357 ATP binding site [chemical binding]; other site 684738006358 putative Mg++ binding site [ion binding]; other site 684738006359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738006360 nucleotide binding region [chemical binding]; other site 684738006361 ATP-binding site [chemical binding]; other site 684738006362 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 684738006363 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 684738006364 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 684738006365 catalytic site [active] 684738006366 G-X2-G-X-G-K; other site 684738006367 phosphodiesterase; Provisional; Region: PRK12704 684738006368 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 684738006369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738006370 Zn2+ binding site [ion binding]; other site 684738006371 Mg2+ binding site [ion binding]; other site 684738006372 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 684738006373 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 684738006374 active site 684738006375 trimer interface [polypeptide binding]; other site 684738006376 allosteric site; other site 684738006377 active site lid [active] 684738006378 hexamer (dimer of trimers) interface [polypeptide binding]; other site 684738006379 S-adenosylmethionine synthetase; Validated; Region: PRK05250 684738006380 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 684738006381 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 684738006382 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 684738006383 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 684738006384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738006385 S-adenosylmethionine binding site [chemical binding]; other site 684738006386 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 684738006387 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 684738006388 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 684738006389 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 684738006390 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 684738006391 Uncharacterized conserved protein [Function unknown]; Region: COG3595 684738006392 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 684738006393 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 684738006394 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 684738006395 CHAP domain; Region: CHAP; pfam05257 684738006396 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 684738006397 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 684738006398 intersubunit interface [polypeptide binding]; other site 684738006399 active site 684738006400 zinc binding site [ion binding]; other site 684738006401 Na+ binding site [ion binding]; other site 684738006402 Predicted membrane protein [Function unknown]; Region: COG2860 684738006403 UPF0126 domain; Region: UPF0126; pfam03458 684738006404 UPF0126 domain; Region: UPF0126; pfam03458 684738006405 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 684738006406 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 684738006407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 684738006408 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 684738006409 active site 684738006410 dimer interface [polypeptide binding]; other site 684738006411 motif 1; other site 684738006412 motif 2; other site 684738006413 motif 3; other site 684738006414 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 684738006415 anticodon binding site; other site 684738006416 ATP cone domain; Region: ATP-cone; pfam03477 684738006417 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 684738006418 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 684738006419 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 684738006420 dimer interface [polypeptide binding]; other site 684738006421 FMN binding site [chemical binding]; other site 684738006422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738006423 active site 684738006424 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 684738006425 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 684738006426 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 684738006427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738006428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738006429 homodimer interface [polypeptide binding]; other site 684738006430 catalytic residue [active] 684738006431 cystathionine gamma-synthase; Reviewed; Region: PRK07269 684738006432 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 684738006433 homodimer interface [polypeptide binding]; other site 684738006434 substrate-cofactor binding pocket; other site 684738006435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738006436 catalytic residue [active] 684738006437 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 684738006438 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 684738006439 proposed active site lysine [active] 684738006440 conserved cys residue [active] 684738006441 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 684738006442 nudix motif; other site 684738006443 Predicted permeases [General function prediction only]; Region: COG0679 684738006444 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 684738006445 active site 684738006446 catalytic residues [active] 684738006447 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 684738006448 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 684738006449 generic binding surface II; other site 684738006450 generic binding surface I; other site 684738006451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 684738006452 Zn2+ binding site [ion binding]; other site 684738006453 Mg2+ binding site [ion binding]; other site 684738006454 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 684738006455 RmuC family; Region: RmuC; pfam02646 684738006456 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 684738006457 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 684738006458 substrate binding site [chemical binding]; other site 684738006459 hexamer interface [polypeptide binding]; other site 684738006460 metal binding site [ion binding]; metal-binding site 684738006461 GTPase RsgA; Reviewed; Region: PRK00098 684738006462 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 684738006463 RNA binding site [nucleotide binding]; other site 684738006464 homodimer interface [polypeptide binding]; other site 684738006465 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 684738006466 GTPase/Zn-binding domain interface [polypeptide binding]; other site 684738006467 GTP/Mg2+ binding site [chemical binding]; other site 684738006468 G4 box; other site 684738006469 G1 box; other site 684738006470 Switch I region; other site 684738006471 G2 box; other site 684738006472 G3 box; other site 684738006473 Switch II region; other site 684738006474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 684738006475 3D domain; Region: 3D; cl01439 684738006476 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 684738006477 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 684738006478 putative tRNA-binding site [nucleotide binding]; other site 684738006479 B3/4 domain; Region: B3_4; pfam03483 684738006480 tRNA synthetase B5 domain; Region: B5; smart00874 684738006481 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 684738006482 dimer interface [polypeptide binding]; other site 684738006483 motif 1; other site 684738006484 motif 3; other site 684738006485 motif 2; other site 684738006486 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 684738006487 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 684738006488 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 684738006489 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 684738006490 dimer interface [polypeptide binding]; other site 684738006491 motif 1; other site 684738006492 active site 684738006493 motif 2; other site 684738006494 motif 3; other site 684738006495 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 684738006496 Predicted transcriptional regulators [Transcription]; Region: COG1695 684738006497 Transcriptional regulator PadR-like family; Region: PadR; cl17335 684738006498 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 684738006499 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 684738006500 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 684738006501 putative active site [active] 684738006502 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 684738006503 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 684738006504 aromatic chitin/cellulose binding site residues [chemical binding]; other site 684738006505 Chitin binding domain; Region: Chitin_bind_3; pfam03067 684738006506 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 684738006507 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 684738006508 GDP-binding site [chemical binding]; other site 684738006509 ACT binding site; other site 684738006510 IMP binding site; other site 684738006511 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 684738006512 Cadmium resistance transporter; Region: Cad; pfam03596 684738006513 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 684738006514 Uncharacterized conserved protein [Function unknown]; Region: COG5646 684738006515 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 684738006516 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 684738006517 dimerization interface [polypeptide binding]; other site 684738006518 domain crossover interface; other site 684738006519 redox-dependent activation switch; other site 684738006520 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 684738006521 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 684738006522 NADP+ binding site [chemical binding]; other site 684738006523 folate binding site [chemical binding]; other site 684738006524 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 684738006525 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 684738006526 FMN binding site [chemical binding]; other site 684738006527 active site 684738006528 catalytic residues [active] 684738006529 substrate binding site [chemical binding]; other site 684738006530 Uncharacterized conserved protein [Function unknown]; Region: COG1284 684738006531 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006532 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006533 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 684738006534 Uncharacterized conserved protein [Function unknown]; Region: COG1284 684738006535 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006537 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 684738006538 Uncharacterized conserved protein [Function unknown]; Region: COG1284 684738006539 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006540 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 684738006541 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 684738006542 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 684738006543 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 684738006544 dimer interface [polypeptide binding]; other site 684738006545 anticodon binding site; other site 684738006546 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 684738006547 homodimer interface [polypeptide binding]; other site 684738006548 motif 1; other site 684738006549 active site 684738006550 motif 2; other site 684738006551 GAD domain; Region: GAD; pfam02938 684738006552 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 684738006553 active site 684738006554 motif 3; other site 684738006555 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 684738006556 nucleotide binding site/active site [active] 684738006557 HIT family signature motif; other site 684738006558 catalytic residue [active] 684738006559 histidyl-tRNA synthetase; Region: hisS; TIGR00442 684738006560 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 684738006561 dimer interface [polypeptide binding]; other site 684738006562 motif 1; other site 684738006563 active site 684738006564 motif 2; other site 684738006565 motif 3; other site 684738006566 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 684738006567 anticodon binding site; other site 684738006568 Transcriptional regulator, Rgg/GadR/MutR family, C-terminal fragment; stop codon 684738006569 Transcriptional regulator, Rgg/GadR/MutR family, N-terminal fragment; stop codon 684738006570 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 684738006571 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 684738006572 Helix-turn-helix domain; Region: HTH_25; pfam13413 684738006573 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 684738006574 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 684738006575 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 684738006576 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 684738006577 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 684738006578 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 684738006579 recF protein; Region: recf; TIGR00611 684738006580 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 684738006581 Walker A/P-loop; other site 684738006582 ATP binding site [chemical binding]; other site 684738006583 Q-loop/lid; other site 684738006584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738006585 ABC transporter signature motif; other site 684738006586 Walker B; other site 684738006587 D-loop; other site 684738006588 H-loop/switch region; other site 684738006589 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 684738006590 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 684738006591 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 684738006592 DNA binding residues [nucleotide binding] 684738006593 putative dimer interface [polypeptide binding]; other site 684738006594 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 684738006595 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 684738006596 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 684738006597 NAD binding site [chemical binding]; other site 684738006598 homodimer interface [polypeptide binding]; other site 684738006599 active site 684738006600 substrate binding site [chemical binding]; other site 684738006601 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 684738006602 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 684738006603 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 684738006604 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 684738006605 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 684738006606 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 684738006607 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 684738006608 active site 684738006609 substrate binding site [chemical binding]; other site 684738006610 trimer interface [polypeptide binding]; other site 684738006611 CoA binding site [chemical binding]; other site 684738006612 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 684738006613 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 684738006614 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 684738006615 galactokinase; Provisional; Region: PRK05322 684738006616 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 684738006617 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 684738006618 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 684738006619 active site 684738006620 catalytic residues [active] 684738006621 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 684738006622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738006623 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738006624 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738006625 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738006626 putative active site [active] 684738006627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 684738006628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 684738006629 active site 684738006630 catalytic tetrad [active] 684738006631 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 684738006632 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 684738006633 active site 684738006634 (T/H)XGH motif; other site 684738006635 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 684738006636 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 684738006637 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 684738006638 NAD binding site [chemical binding]; other site 684738006639 ligand binding site [chemical binding]; other site 684738006640 catalytic site [active] 684738006641 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 684738006642 Peptidase family U32; Region: Peptidase_U32; pfam01136 684738006643 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 684738006644 Peptidase family U32; Region: Peptidase_U32; pfam01136 684738006645 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 684738006646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 684738006647 Methyltransferase domain; Region: Methyltransf_11; pfam08241 684738006648 S-adenosylmethionine binding site [chemical binding]; other site 684738006649 CutC family; Region: CutC; pfam03932 684738006650 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 684738006651 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 684738006652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738006653 Walker A/P-loop; other site 684738006654 ATP binding site [chemical binding]; other site 684738006655 Q-loop/lid; other site 684738006656 ABC transporter signature motif; other site 684738006657 Walker B; other site 684738006658 D-loop; other site 684738006659 H-loop/switch region; other site 684738006660 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 684738006661 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 684738006662 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 684738006663 putative active site [active] 684738006664 catalytic site [active] 684738006665 putative metal binding site [ion binding]; other site 684738006666 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 684738006667 HIT family signature motif; other site 684738006668 catalytic residue [active] 684738006669 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 684738006670 mRNA/rRNA interface [nucleotide binding]; other site 684738006671 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 684738006672 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 684738006673 23S rRNA interface [nucleotide binding]; other site 684738006674 L7/L12 interface [polypeptide binding]; other site 684738006675 putative thiostrepton binding site; other site 684738006676 L25 interface [polypeptide binding]; other site 684738006677 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 684738006678 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 684738006679 Walker A/P-loop; other site 684738006680 ATP binding site [chemical binding]; other site 684738006681 Q-loop/lid; other site 684738006682 ABC transporter signature motif; other site 684738006683 Walker B; other site 684738006684 D-loop; other site 684738006685 H-loop/switch region; other site 684738006686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 684738006687 methionine sulfoxide reductase A; Provisional; Region: PRK14054 684738006688 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 684738006689 S1 domain; Region: S1_2; pfam13509 684738006690 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 684738006691 RNA binding site [nucleotide binding]; other site 684738006692 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 684738006693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738006694 Coenzyme A binding pocket [chemical binding]; other site 684738006695 ribosome recycling factor; Reviewed; Region: frr; PRK00083 684738006696 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 684738006697 hinge region; other site 684738006698 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 684738006699 putative nucleotide binding site [chemical binding]; other site 684738006700 uridine monophosphate binding site [chemical binding]; other site 684738006701 homohexameric interface [polypeptide binding]; other site 684738006702 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 684738006703 propionate/acetate kinase; Provisional; Region: PRK12379 684738006704 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 684738006705 propionate/acetate kinase; Provisional; Region: PRK12379 684738006706 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 684738006707 Methyltransferase domain; Region: Methyltransf_26; pfam13659 684738006708 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 684738006709 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 684738006710 G1 box; other site 684738006711 putative GEF interaction site [polypeptide binding]; other site 684738006712 GTP/Mg2+ binding site [chemical binding]; other site 684738006713 Switch I region; other site 684738006714 G2 box; other site 684738006715 G3 box; other site 684738006716 Switch II region; other site 684738006717 G4 box; other site 684738006718 G5 box; other site 684738006719 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 684738006720 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 684738006721 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738006722 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 684738006723 Walker A/P-loop; other site 684738006724 ATP binding site [chemical binding]; other site 684738006725 Q-loop/lid; other site 684738006726 ABC transporter signature motif; other site 684738006727 Walker B; other site 684738006728 D-loop; other site 684738006729 H-loop/switch region; other site 684738006730 ABC transporter, permease protein, C-terminal fragment; frameshift 684738006731 ABC transporter, permease protein, N-terminal fragment; frameshift 684738006732 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 684738006733 LytTr DNA-binding domain; Region: LytTR; pfam04397 684738006734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 684738006735 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 684738006736 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738006737 nucleotide binding site [chemical binding]; other site 684738006738 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 684738006739 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 684738006740 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 684738006741 dimerization interface [polypeptide binding]; other site 684738006742 DPS ferroxidase diiron center [ion binding]; other site 684738006743 ion pore; other site 684738006744 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 684738006745 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 684738006746 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 684738006747 active site 684738006748 DNA polymerase IV; Validated; Region: PRK02406 684738006749 DNA binding site [nucleotide binding] 684738006750 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 684738006751 putative deacylase active site [active] 684738006752 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 684738006753 transaminase; Validated; Region: PRK07324 684738006754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 684738006755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738006756 homodimer interface [polypeptide binding]; other site 684738006757 catalytic residue [active] 684738006758 carbamate kinase; Reviewed; Region: PRK12686 684738006759 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 684738006760 putative substrate binding site [chemical binding]; other site 684738006761 nucleotide binding site [chemical binding]; other site 684738006762 nucleotide binding site [chemical binding]; other site 684738006763 homodimer interface [polypeptide binding]; other site 684738006764 carbamate kinase; Reviewed; Region: PRK12686 684738006765 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 684738006766 putative substrate binding site [chemical binding]; other site 684738006767 nucleotide binding site [chemical binding]; other site 684738006768 nucleotide binding site [chemical binding]; other site 684738006769 homodimer interface [polypeptide binding]; other site 684738006770 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 684738006771 ornithine carbamoyltransferase; Validated; Region: PRK02102 684738006772 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 684738006773 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 684738006774 arginine deiminase; Provisional; Region: PRK01388 684738006775 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 684738006776 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 684738006777 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 684738006778 active site 684738006779 HIGH motif; other site 684738006780 KMSK motif region; other site 684738006781 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 684738006782 tRNA binding surface [nucleotide binding]; other site 684738006783 anticodon binding site; other site 684738006784 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 684738006785 arginine repressor; Region: argR_whole; TIGR01529 684738006786 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 684738006787 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 684738006788 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 684738006789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 684738006790 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 684738006791 SWIM zinc finger; Region: SWIM; pfam04434 684738006792 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 684738006793 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 684738006794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738006795 ATP binding site [chemical binding]; other site 684738006796 putative Mg++ binding site [ion binding]; other site 684738006797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738006798 nucleotide binding region [chemical binding]; other site 684738006799 ATP-binding site [chemical binding]; other site 684738006800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738006801 active site 684738006802 DNA binding site [nucleotide binding] 684738006803 Int/Topo IB signature motif; other site 684738006804 Antirestriction protein (ArdA); Region: ArdA; pfam07275 684738006805 CHAP domain; Region: CHAP; pfam05257 684738006806 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 684738006807 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 684738006808 AAA-like domain; Region: AAA_10; pfam12846 684738006809 TcpE family; Region: TcpE; pfam12648 684738006810 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 684738006811 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 684738006812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738006813 non-specific DNA binding site [nucleotide binding]; other site 684738006814 salt bridge; other site 684738006815 sequence-specific DNA binding site [nucleotide binding]; other site 684738006816 Replication initiation factor; Region: Rep_trans; pfam02486 684738006817 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 684738006818 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 684738006819 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 684738006820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738006821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738006822 non-specific DNA binding site [nucleotide binding]; other site 684738006823 salt bridge; other site 684738006824 sequence-specific DNA binding site [nucleotide binding]; other site 684738006825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738006826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738006827 non-specific DNA binding site [nucleotide binding]; other site 684738006828 salt bridge; other site 684738006829 sequence-specific DNA binding site [nucleotide binding]; other site 684738006830 Domain of unknown function (DUF955); Region: DUF955; cl01076 684738006831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738006832 Transposase; Region: HTH_Tnp_1; pfam01527 684738006833 Transposase; Region: HTH_Tnp_1; cl17663 684738006834 IS1216 transposase A, N-terminal fragment; frameshift 684738006835 IS1216 transposase A, C-terminal fragment; frameshift 684738006836 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 684738006837 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 684738006838 active site 684738006839 homodimer interface [polypeptide binding]; other site 684738006840 catalytic site [active] 684738006841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 684738006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738006843 dimer interface [polypeptide binding]; other site 684738006844 conserved gate region; other site 684738006845 putative PBP binding loops; other site 684738006846 ABC-ATPase subunit interface; other site 684738006847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 684738006848 dimer interface [polypeptide binding]; other site 684738006849 conserved gate region; other site 684738006850 putative PBP binding loops; other site 684738006851 ABC-ATPase subunit interface; other site 684738006852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 684738006853 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 684738006854 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 684738006855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 684738006856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 684738006857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 684738006858 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 684738006859 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 684738006860 purine monophosphate binding site [chemical binding]; other site 684738006861 dimer interface [polypeptide binding]; other site 684738006862 putative catalytic residues [active] 684738006863 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 684738006864 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 684738006865 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 684738006866 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 684738006867 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 684738006868 galactokinase; Provisional; Region: PRK05322 684738006869 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 684738006870 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 684738006871 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 684738006872 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 684738006873 Melibiase; Region: Melibiase; pfam02065 684738006874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738006875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738006876 DNA binding site [nucleotide binding] 684738006877 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 684738006878 putative dimerization interface [polypeptide binding]; other site 684738006879 putative ligand binding site [chemical binding]; other site 684738006880 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 684738006881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 684738006882 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 684738006883 IS1216 transposase A, N-terminal fragment; frameshift 684738006884 IS1216 transposase A, C-terminal fragment; frameshift 684738006885 putative transposase OrfB; Reviewed; Region: PHA02517 684738006886 HTH-like domain; Region: HTH_21; pfam13276 684738006887 Integrase core domain; Region: rve; pfam00665 684738006888 Integrase core domain; Region: rve_3; pfam13683 684738006889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738006890 Transposase; Region: HTH_Tnp_1; pfam01527 684738006891 putative transposase OrfB; Reviewed; Region: PHA02517 684738006892 HTH-like domain; Region: HTH_21; pfam13276 684738006893 Integrase core domain; Region: rve; pfam00665 684738006894 Integrase core domain; Region: rve_3; pfam13683 684738006895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738006896 Transposase; Region: HTH_Tnp_1; pfam01527 684738006897 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 684738006898 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 684738006899 putative ligand binding site [chemical binding]; other site 684738006900 putative NAD binding site [chemical binding]; other site 684738006901 catalytic site [active] 684738006902 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 684738006903 putative active site [active] 684738006904 putative ligand binding site [chemical binding]; other site 684738006905 putative NAD(P) binding site [chemical binding]; other site 684738006906 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 684738006907 oligomer interface [polypeptide binding]; other site 684738006908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 684738006909 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 684738006910 Predicted membrane protein [Function unknown]; Region: COG2261 684738006911 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738006912 DNA-binding site [nucleotide binding]; DNA binding site 684738006913 RNA-binding motif; other site 684738006914 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 684738006915 DNA-binding site [nucleotide binding]; DNA binding site 684738006916 RNA-binding motif; other site 684738006917 Hypothetical protein, extracellular, C-terminal fragment; frameshift 684738006918 Hypothetical protein, extracellular, N-terminal fragment; frameshift 684738006919 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 684738006920 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 684738006921 PYR/PP interface [polypeptide binding]; other site 684738006922 dimer interface [polypeptide binding]; other site 684738006923 tetramer interface [polypeptide binding]; other site 684738006924 TPP binding site [chemical binding]; other site 684738006925 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 684738006926 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 684738006927 TPP-binding site [chemical binding]; other site 684738006928 Beta-lactamase; Region: Beta-lactamase; pfam00144 684738006929 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 684738006930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 684738006931 CAAX protease self-immunity; Region: Abi; pfam02517 684738006932 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 684738006933 amphipathic channel; other site 684738006934 Asn-Pro-Ala signature motifs; other site 684738006935 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 684738006936 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 684738006937 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 684738006938 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 684738006939 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 684738006940 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 684738006941 catalytic triad [active] 684738006942 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 684738006943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 684738006944 substrate binding pocket [chemical binding]; other site 684738006945 membrane-bound complex binding site; other site 684738006946 hinge residues; other site 684738006947 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 684738006948 TrkA-N domain; Region: TrkA_N; pfam02254 684738006949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738006950 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738006951 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 684738006952 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 684738006953 active site 684738006954 HIGH motif; other site 684738006955 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 684738006956 active site 684738006957 KMSKS motif; other site 684738006958 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 684738006959 Isochorismatase family; Region: Isochorismatase; pfam00857 684738006960 catalytic triad [active] 684738006961 conserved cis-peptide bond; other site 684738006962 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 684738006963 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 684738006964 active site 684738006965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 684738006966 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 684738006967 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 684738006968 Predicted transcriptional regulators [Transcription]; Region: COG1695 684738006969 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 684738006970 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 684738006971 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 684738006972 putative active site [active] 684738006973 Predicted membrane protein [Function unknown]; Region: COG3619 684738006974 DNA repair protein RadA; Provisional; Region: PRK11823 684738006975 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 684738006976 Walker A motif/ATP binding site; other site 684738006977 ATP binding site [chemical binding]; other site 684738006978 Walker B motif; other site 684738006979 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 684738006980 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 684738006981 metal-binding site [ion binding] 684738006982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738006983 active site 684738006984 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 684738006985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738006986 active site 684738006987 motif I; other site 684738006988 motif II; other site 684738006989 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738006990 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 684738006991 dimer interface [polypeptide binding]; other site 684738006992 active site 684738006993 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 684738006994 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 684738006995 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 684738006996 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 684738006997 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 684738006998 GDP-Fucose binding site [chemical binding]; other site 684738006999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738007000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738007001 active site 684738007002 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 684738007003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 684738007004 active site 684738007005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 684738007006 FemAB family; Region: FemAB; pfam02388 684738007007 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 684738007008 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 684738007009 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 684738007010 alphaNTD homodimer interface [polypeptide binding]; other site 684738007011 alphaNTD - beta interaction site [polypeptide binding]; other site 684738007012 alphaNTD - beta' interaction site [polypeptide binding]; other site 684738007013 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 684738007014 30S ribosomal protein S11; Validated; Region: PRK05309 684738007015 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 684738007016 30S ribosomal protein S13; Region: bact_S13; TIGR03631 684738007017 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 684738007018 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 684738007019 rRNA binding site [nucleotide binding]; other site 684738007020 predicted 30S ribosome binding site; other site 684738007021 adenylate kinase; Reviewed; Region: adk; PRK00279 684738007022 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 684738007023 AMP-binding site [chemical binding]; other site 684738007024 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 684738007025 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 684738007026 SecY translocase; Region: SecY; pfam00344 684738007027 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 684738007028 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 684738007029 23S rRNA binding site [nucleotide binding]; other site 684738007030 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 684738007031 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 684738007032 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 684738007033 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 684738007034 5S rRNA interface [nucleotide binding]; other site 684738007035 L27 interface [polypeptide binding]; other site 684738007036 23S rRNA interface [nucleotide binding]; other site 684738007037 L5 interface [polypeptide binding]; other site 684738007038 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 684738007039 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 684738007040 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 684738007041 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 684738007042 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 684738007043 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 684738007044 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 684738007045 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 684738007046 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 684738007047 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 684738007048 RNA binding site [nucleotide binding]; other site 684738007049 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 684738007050 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 684738007051 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 684738007052 23S rRNA interface [nucleotide binding]; other site 684738007053 putative translocon interaction site; other site 684738007054 signal recognition particle (SRP54) interaction site; other site 684738007055 L23 interface [polypeptide binding]; other site 684738007056 trigger factor interaction site; other site 684738007057 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 684738007058 23S rRNA interface [nucleotide binding]; other site 684738007059 5S rRNA interface [nucleotide binding]; other site 684738007060 putative antibiotic binding site [chemical binding]; other site 684738007061 L25 interface [polypeptide binding]; other site 684738007062 L27 interface [polypeptide binding]; other site 684738007063 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 684738007064 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 684738007065 G-X-X-G motif; other site 684738007066 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 684738007067 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 684738007068 putative translocon binding site; other site 684738007069 protein-rRNA interface [nucleotide binding]; other site 684738007070 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 684738007071 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 684738007072 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 684738007073 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 684738007074 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 684738007075 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 684738007076 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 684738007077 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 684738007078 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 684738007079 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 684738007080 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 684738007081 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 684738007082 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 684738007083 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 684738007084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 684738007085 catalytic residue [active] 684738007086 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 684738007087 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 684738007088 putative homodimer interface [polypeptide binding]; other site 684738007089 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 684738007090 heterodimer interface [polypeptide binding]; other site 684738007091 homodimer interface [polypeptide binding]; other site 684738007092 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 684738007093 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 684738007094 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 684738007095 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 684738007096 catalytic triad [active] 684738007097 catalytic triad [active] 684738007098 oxyanion hole [active] 684738007099 Transglycosylase; Region: Transgly; pfam00912 684738007100 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 684738007101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 684738007102 Predicted membrane protein [Function unknown]; Region: COG2323 684738007103 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 684738007104 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 684738007105 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 684738007106 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 684738007107 active site 684738007108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 684738007109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 684738007110 ABC-ATPase subunit interface; other site 684738007111 dimer interface [polypeptide binding]; other site 684738007112 putative PBP binding regions; other site 684738007113 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 684738007114 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 684738007115 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 684738007116 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 684738007117 metal binding site [ion binding]; metal-binding site 684738007118 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 684738007119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738007120 putative DNA binding site [nucleotide binding]; other site 684738007121 putative Zn2+ binding site [ion binding]; other site 684738007122 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 684738007123 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 684738007124 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 684738007125 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 684738007126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 684738007127 Type II/IV secretion system protein; Region: T2SE; pfam00437 684738007128 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 684738007129 Walker A motif; other site 684738007130 ATP binding site [chemical binding]; other site 684738007131 Walker B motif; other site 684738007132 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 684738007133 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 684738007134 generic binding surface II; other site 684738007135 generic binding surface I; other site 684738007136 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 684738007137 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 684738007138 generic binding surface II; other site 684738007139 generic binding surface I; other site 684738007140 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 684738007141 active site 684738007142 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 684738007143 active site 684738007144 catalytic site [active] 684738007145 substrate binding site [chemical binding]; other site 684738007146 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 684738007147 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 684738007148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 684738007149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 684738007150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 684738007151 prolyl-tRNA synthetase; Provisional; Region: PRK09194 684738007152 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 684738007153 dimer interface [polypeptide binding]; other site 684738007154 motif 1; other site 684738007155 active site 684738007156 motif 2; other site 684738007157 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 684738007158 putative deacylase active site [active] 684738007159 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 684738007160 active site 684738007161 motif 3; other site 684738007162 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 684738007163 anticodon binding site; other site 684738007164 RIP metalloprotease RseP; Region: TIGR00054 684738007165 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 684738007166 active site 684738007167 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 684738007168 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 684738007169 protein binding site [polypeptide binding]; other site 684738007170 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 684738007171 putative substrate binding region [chemical binding]; other site 684738007172 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 684738007173 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 684738007174 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 684738007175 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 684738007176 catalytic residue [active] 684738007177 putative FPP diphosphate binding site; other site 684738007178 putative FPP binding hydrophobic cleft; other site 684738007179 dimer interface [polypeptide binding]; other site 684738007180 putative IPP diphosphate binding site; other site 684738007181 Preprotein translocase subunit; Region: YajC; cl00806 684738007182 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 684738007183 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 684738007184 active site 684738007185 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 684738007186 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 684738007187 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 684738007188 protein binding site [polypeptide binding]; other site 684738007189 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 684738007190 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738007191 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 684738007192 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 684738007193 putative ADP-binding pocket [chemical binding]; other site 684738007194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 684738007195 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 684738007196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738007197 S-adenosylmethionine binding site [chemical binding]; other site 684738007198 DNA polymerase I; Provisional; Region: PRK05755 684738007199 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 684738007200 active site 684738007201 metal binding site 1 [ion binding]; metal-binding site 684738007202 putative 5' ssDNA interaction site; other site 684738007203 metal binding site 3; metal-binding site 684738007204 metal binding site 2 [ion binding]; metal-binding site 684738007205 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 684738007206 putative DNA binding site [nucleotide binding]; other site 684738007207 putative metal binding site [ion binding]; other site 684738007208 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 684738007209 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 684738007210 active site 684738007211 DNA binding site [nucleotide binding] 684738007212 catalytic site [active] 684738007213 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 684738007214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 684738007215 active site 684738007216 motif I; other site 684738007217 motif II; other site 684738007218 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 684738007219 Transcriptional regulators [Transcription]; Region: PurR; COG1609 684738007220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 684738007221 DNA binding site [nucleotide binding] 684738007222 domain linker motif; other site 684738007223 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 684738007224 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 684738007225 elongation factor Ts; Provisional; Region: tsf; PRK09377 684738007226 UBA/TS-N domain; Region: UBA; pfam00627 684738007227 Elongation factor TS; Region: EF_TS; pfam00889 684738007228 Elongation factor TS; Region: EF_TS; pfam00889 684738007229 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 684738007230 rRNA interaction site [nucleotide binding]; other site 684738007231 S8 interaction site; other site 684738007232 putative laminin-1 binding site; other site 684738007233 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 684738007234 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 684738007235 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 684738007236 putative catalytic cysteine [active] 684738007237 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 684738007238 putative active site [active] 684738007239 metal binding site [ion binding]; metal-binding site 684738007240 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 684738007241 dimer interface [polypeptide binding]; other site 684738007242 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 684738007243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738007244 FeS/SAM binding site; other site 684738007245 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 684738007246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738007247 FeS/SAM binding site; other site 684738007248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738007249 Helix-turn-helix domain; Region: HTH_19; pfam12844 684738007250 non-specific DNA binding site [nucleotide binding]; other site 684738007251 salt bridge; other site 684738007252 sequence-specific DNA binding site [nucleotide binding]; other site 684738007253 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738007254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738007255 KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080 684738007256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738007257 FeS/SAM binding site; other site 684738007258 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 684738007259 KxxxW-cyclized secreted peptide; Region: phero_cyc_pep; TIGR04079 684738007260 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 684738007261 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 684738007262 protein binding site [polypeptide binding]; other site 684738007263 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 684738007264 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 684738007265 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 684738007266 active site 684738007267 (T/H)XGH motif; other site 684738007268 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 684738007269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738007270 S-adenosylmethionine binding site [chemical binding]; other site 684738007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738007272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738007273 putative substrate translocation pore; other site 684738007274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738007275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738007276 putative substrate translocation pore; other site 684738007277 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 684738007278 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 684738007279 DNA binding residues [nucleotide binding] 684738007280 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 684738007281 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 684738007282 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 684738007283 active site 684738007284 dimer interface [polypeptide binding]; other site 684738007285 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 684738007286 dimer interface [polypeptide binding]; other site 684738007287 active site 684738007288 Flagellin N-methylase; Region: FliB; pfam03692 684738007289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738007290 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 684738007291 NAD(P) binding site [chemical binding]; other site 684738007292 active site 684738007293 Predicted transcriptional regulators [Transcription]; Region: COG1733 684738007294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 684738007295 dimerization interface [polypeptide binding]; other site 684738007296 putative DNA binding site [nucleotide binding]; other site 684738007297 putative Zn2+ binding site [ion binding]; other site 684738007298 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 684738007299 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 684738007300 active site 684738007301 HIGH motif; other site 684738007302 nucleotide binding site [chemical binding]; other site 684738007303 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 684738007304 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 684738007305 active site 684738007306 KMSKS motif; other site 684738007307 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 684738007308 tRNA binding surface [nucleotide binding]; other site 684738007309 anticodon binding site; other site 684738007310 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 684738007311 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 684738007312 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 684738007313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 684738007314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 684738007315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738007316 Coenzyme A binding pocket [chemical binding]; other site 684738007317 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 684738007318 B3/4 domain; Region: B3_4; pfam03483 684738007319 TRAM domain; Region: TRAM; pfam01938 684738007320 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 684738007321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 684738007322 S-adenosylmethionine binding site [chemical binding]; other site 684738007323 legume lectins; Region: lectin_L-type; cd01951 684738007324 homotetramer interaction site [polypeptide binding]; other site 684738007325 carbohydrate binding site [chemical binding]; other site 684738007326 metal binding site [ion binding]; metal-binding site 684738007327 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 684738007328 MucBP domain; Region: MucBP; pfam06458 684738007329 MucBP domain; Region: MucBP; pfam06458 684738007330 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 684738007331 recombination regulator RecX; Provisional; Region: recX; PRK14135 684738007332 fructuronate transporter; Provisional; Region: PRK10034; cl15264 684738007333 GntP family permease; Region: GntP_permease; pfam02447 684738007334 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 684738007335 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 684738007336 N- and C-terminal domain interface [polypeptide binding]; other site 684738007337 active site 684738007338 catalytic site [active] 684738007339 metal binding site [ion binding]; metal-binding site 684738007340 carbohydrate binding site [chemical binding]; other site 684738007341 ATP binding site [chemical binding]; other site 684738007342 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 684738007343 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 684738007344 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 684738007345 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 684738007346 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 684738007347 putative active site [active] 684738007348 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 684738007349 phosphodiesterase YaeI; Provisional; Region: PRK11340 684738007350 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 684738007351 putative active site [active] 684738007352 putative metal binding site [ion binding]; other site 684738007353 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 684738007354 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 684738007355 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 684738007356 dimer interface [polypeptide binding]; other site 684738007357 ssDNA binding site [nucleotide binding]; other site 684738007358 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738007359 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 684738007360 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 684738007361 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 684738007362 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 684738007363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738007364 Walker A motif; other site 684738007365 ATP binding site [chemical binding]; other site 684738007366 Walker B motif; other site 684738007367 arginine finger; other site 684738007368 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 684738007369 Phosphotransferase enzyme family; Region: APH; pfam01636 684738007370 substrate binding site [chemical binding]; other site 684738007371 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 684738007372 GAF domain; Region: GAF_2; pfam13185 684738007373 hypothetical protein; Provisional; Region: PRK07248 684738007374 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 684738007375 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 684738007376 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 684738007377 Int/Topo IB signature motif; other site 684738007378 Enterocin A Immunity; Region: EntA_Immun; pfam08951 684738007379 conserved hypothetical protein; Region: TIGR02328 684738007380 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 684738007381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738007382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738007383 non-specific DNA binding site [nucleotide binding]; other site 684738007384 salt bridge; other site 684738007385 sequence-specific DNA binding site [nucleotide binding]; other site 684738007386 BRO family, N-terminal domain; Region: Bro-N; smart01040 684738007387 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 684738007388 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 684738007389 polymerase nucleotide-binding site; other site 684738007390 DNA-binding residues [nucleotide binding]; DNA binding site 684738007391 nucleotide binding site [chemical binding]; other site 684738007392 primase nucleotide-binding site [nucleotide binding]; other site 684738007393 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 684738007394 Phage associated DNA primase [General function prediction only]; Region: COG3378 684738007395 D5 N terminal like; Region: D5_N; smart00885 684738007396 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 684738007397 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 684738007398 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 684738007399 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 684738007400 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 684738007401 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 684738007402 DNA binding residues [nucleotide binding] 684738007403 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 684738007404 Low molecular weight phosphatase family; Region: LMWPc; cd00115 684738007405 active site 684738007406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 684738007407 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 684738007408 Walker A/P-loop; other site 684738007409 ATP binding site [chemical binding]; other site 684738007410 Q-loop/lid; other site 684738007411 ABC transporter signature motif; other site 684738007412 Walker B; other site 684738007413 D-loop; other site 684738007414 H-loop/switch region; other site 684738007415 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 684738007416 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 684738007417 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 684738007418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 684738007419 Walker A motif; other site 684738007420 ATP binding site [chemical binding]; other site 684738007421 Walker B motif; other site 684738007422 arginine finger; other site 684738007423 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 684738007424 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 684738007425 RuvA N terminal domain; Region: RuvA_N; pfam01330 684738007426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 684738007427 helix-hairpin-helix signature motif; other site 684738007428 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 684738007429 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 684738007430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 684738007431 ATP binding site [chemical binding]; other site 684738007432 Mg2+ binding site [ion binding]; other site 684738007433 G-X-G motif; other site 684738007434 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 684738007435 ATP binding site [chemical binding]; other site 684738007436 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 684738007437 Protein of unknown function (DUF805); Region: DUF805; pfam05656 684738007438 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 684738007439 MutS domain I; Region: MutS_I; pfam01624 684738007440 MutS domain II; Region: MutS_II; pfam05188 684738007441 MutS domain III; Region: MutS_III; pfam05192 684738007442 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 684738007443 Walker A/P-loop; other site 684738007444 ATP binding site [chemical binding]; other site 684738007445 Q-loop/lid; other site 684738007446 ABC transporter signature motif; other site 684738007447 Walker B; other site 684738007448 D-loop; other site 684738007449 H-loop/switch region; other site 684738007450 Predicted membrane protein [Function unknown]; Region: COG4550 684738007451 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 684738007452 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 684738007453 Predicted membrane protein [Function unknown]; Region: COG4272 684738007454 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 684738007455 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 684738007456 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 684738007457 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 684738007458 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 684738007459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738007460 active site 684738007461 motif I; other site 684738007462 motif II; other site 684738007463 chaperone protein DnaJ; Provisional; Region: PRK14276 684738007464 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 684738007465 HSP70 interaction site [polypeptide binding]; other site 684738007466 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 684738007467 substrate binding site [polypeptide binding]; other site 684738007468 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 684738007469 Zn binding sites [ion binding]; other site 684738007470 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 684738007471 substrate binding site [polypeptide binding]; other site 684738007472 dimer interface [polypeptide binding]; other site 684738007473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 684738007474 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 684738007475 aspartate racemase; Region: asp_race; TIGR00035 684738007476 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 684738007477 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 684738007478 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 684738007479 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 684738007480 active site 684738007481 dimer interface [polypeptide binding]; other site 684738007482 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 684738007483 Ligand Binding Site [chemical binding]; other site 684738007484 Molecular Tunnel; other site 684738007485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 684738007486 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 684738007487 Surface antigen [General function prediction only]; Region: COG3942 684738007488 CHAP domain; Region: CHAP; pfam05257 684738007489 rod shape-determining protein MreD; Region: MreD; pfam04093 684738007490 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 684738007491 rod shape-determining protein MreC; Region: MreC; pfam04085 684738007492 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 684738007493 nudix motif; other site 684738007494 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 684738007495 tetramer (dimer of dimers) interface [polypeptide binding]; other site 684738007496 active site 684738007497 dimer interface [polypeptide binding]; other site 684738007498 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 684738007499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 684738007500 ligand binding site [chemical binding]; other site 684738007501 flexible hinge region; other site 684738007502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 684738007503 putative switch regulator; other site 684738007504 non-specific DNA interactions [nucleotide binding]; other site 684738007505 DNA binding site [nucleotide binding] 684738007506 sequence specific DNA binding site [nucleotide binding]; other site 684738007507 putative cAMP binding site [chemical binding]; other site 684738007508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 684738007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 684738007510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 684738007511 Ligand Binding Site [chemical binding]; other site 684738007512 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 684738007513 nucleotide binding site [chemical binding]; other site 684738007514 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 684738007515 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 684738007516 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 684738007517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 684738007518 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 684738007519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 684738007520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738007521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738007522 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 684738007523 heme-binding site [chemical binding]; other site 684738007524 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 684738007525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 684738007526 RNA binding surface [nucleotide binding]; other site 684738007527 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 684738007528 active site 684738007529 uracil binding [chemical binding]; other site 684738007530 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase, N-terminal fragment; stop codon 684738007531 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase, C-terminal fragment; stop codon 684738007532 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 684738007533 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 684738007534 generic binding surface II; other site 684738007535 ssDNA binding site; other site 684738007536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 684738007537 ATP binding site [chemical binding]; other site 684738007538 putative Mg++ binding site [ion binding]; other site 684738007539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 684738007540 nucleotide binding region [chemical binding]; other site 684738007541 ATP-binding site [chemical binding]; other site 684738007542 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 684738007543 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 684738007544 PhnA protein; Region: PhnA; pfam03831 684738007545 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 684738007546 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 684738007547 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 684738007548 phosphodiesterase; Provisional; Region: PRK12704 684738007549 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 684738007550 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 684738007551 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738007552 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 684738007553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 684738007554 motif II; other site 684738007555 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 684738007556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 684738007557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 684738007558 oxidoreductase; Provisional; Region: PRK06196 684738007559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 684738007560 NAD(P) binding site [chemical binding]; other site 684738007561 active site 684738007562 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 684738007563 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 684738007564 23S rRNA interface [nucleotide binding]; other site 684738007565 L3 interface [polypeptide binding]; other site 684738007566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 684738007567 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 684738007568 FtsX-like permease family; Region: FtsX; pfam02687 684738007569 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 684738007570 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 684738007571 Walker A/P-loop; other site 684738007572 ATP binding site [chemical binding]; other site 684738007573 Q-loop/lid; other site 684738007574 ABC transporter signature motif; other site 684738007575 Walker B; other site 684738007576 D-loop; other site 684738007577 H-loop/switch region; other site 684738007578 ribonuclease HIII; Provisional; Region: PRK00996 684738007579 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 684738007580 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 684738007581 RNA/DNA hybrid binding site [nucleotide binding]; other site 684738007582 active site 684738007583 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 684738007584 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 684738007585 Catalytic site [active] 684738007586 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 684738007587 pur operon repressor; Provisional; Region: PRK09213 684738007588 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 684738007589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 684738007590 active site 684738007591 elongation factor G; Reviewed; Region: PRK00007 684738007592 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 684738007593 G1 box; other site 684738007594 putative GEF interaction site [polypeptide binding]; other site 684738007595 GTP/Mg2+ binding site [chemical binding]; other site 684738007596 Switch I region; other site 684738007597 G2 box; other site 684738007598 G3 box; other site 684738007599 Switch II region; other site 684738007600 G4 box; other site 684738007601 G5 box; other site 684738007602 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 684738007603 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 684738007604 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 684738007605 30S ribosomal protein S7; Validated; Region: PRK05302 684738007606 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 684738007607 S17 interaction site [polypeptide binding]; other site 684738007608 S8 interaction site; other site 684738007609 16S rRNA interaction site [nucleotide binding]; other site 684738007610 streptomycin interaction site [chemical binding]; other site 684738007611 23S rRNA interaction site [nucleotide binding]; other site 684738007612 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 684738007613 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 684738007614 Beta-lactamase; Region: Beta-lactamase; cl17358 684738007615 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 684738007616 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 684738007617 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 684738007618 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 684738007619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 684738007620 FeS/SAM binding site; other site 684738007621 Initiator Replication protein; Region: Rep_3; pfam01051 684738007622 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 684738007623 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 684738007624 P-loop; other site 684738007625 Magnesium ion binding site [ion binding]; other site 684738007626 ParB-like nuclease domain; Region: ParB; smart00470 684738007627 DNA polymerase IV; Reviewed; Region: PRK03103 684738007628 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 684738007629 active site 684738007630 DNA binding site [nucleotide binding] 684738007631 transposase of IS1297, IS6 familiy (pseudogene) 684738007632 CAAX protease self-immunity; Region: Abi; pfam02517 684738007633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738007634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738007635 non-specific DNA binding site [nucleotide binding]; other site 684738007636 salt bridge; other site 684738007637 sequence-specific DNA binding site [nucleotide binding]; other site 684738007638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 684738007639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 684738007640 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 684738007641 Predicted transcriptional regulators [Transcription]; Region: COG1695 684738007642 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 684738007643 multiple promoter invertase; Provisional; Region: mpi; PRK13413 684738007644 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 684738007645 catalytic residues [active] 684738007646 catalytic nucleophile [active] 684738007647 Presynaptic Site I dimer interface [polypeptide binding]; other site 684738007648 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 684738007649 Synaptic Flat tetramer interface [polypeptide binding]; other site 684738007650 Synaptic Site I dimer interface [polypeptide binding]; other site 684738007651 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 684738007652 DNA-binding interface [nucleotide binding]; DNA binding site 684738007653 transposase of IS981, IS3 family, C-terminus; frameshift 684738007654 transposase of IS981, IS3 family, N-terminus; frameshift 684738007655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 684738007656 Transposase; Region: HTH_Tnp_1; pfam01527 684738007657 K+ potassium transporter; Region: K_trans; cl15781 684738007658 transposase of IS1068, IS3 family, N-terminus; frameshift 684738007659 transposase of IS1068, IS3 family, C-terminus; frameshift 684738007660 multiple promoter invertase; Provisional; Region: mpi; PRK13413 684738007661 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 684738007662 catalytic residues [active] 684738007663 catalytic nucleophile [active] 684738007664 Presynaptic Site I dimer interface [polypeptide binding]; other site 684738007665 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 684738007666 Synaptic Flat tetramer interface [polypeptide binding]; other site 684738007667 Synaptic Site I dimer interface [polypeptide binding]; other site 684738007668 DNA binding site [nucleotide binding] 684738007669 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 684738007670 DNA-binding interface [nucleotide binding]; DNA binding site 684738007671 transposase of IS1297, IS6 familiy, N-terminus; stop codon 684738007672 transposase of IS1297, IS6 familiy, C-terminus; stop codon 684738007673 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 684738007674 myosin-cross-reactive antigen; Provisional; Region: PRK13977 684738007675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 684738007676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 684738007677 Coenzyme A binding pocket [chemical binding]; other site 684738007678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 684738007679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 684738007680 non-specific DNA binding site [nucleotide binding]; other site 684738007681 salt bridge; other site 684738007682 sequence-specific DNA binding site [nucleotide binding]; other site 684738007683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 684738007684 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 684738007685 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 684738007686 ligand binding site [chemical binding]; other site 684738007687 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 684738007688 putative switch regulator; other site 684738007689 non-specific DNA interactions [nucleotide binding]; other site 684738007690 DNA binding site [nucleotide binding] 684738007691 sequence specific DNA binding site [nucleotide binding]; other site 684738007692 putative cAMP binding site [chemical binding]; other site 684738007693 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 684738007694 dinuclear metal binding motif [ion binding]; other site 684738007695 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 684738007696 metal-binding site [ion binding] 684738007697 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 684738007698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 684738007699 Soluble P-type ATPase [General function prediction only]; Region: COG4087 684738007700 transposase of IS1297, IS6 familiy, C-terminus; stop codon 684738007701 transposase of IS1297, IS6 familiy, N-terminus; stop codon