-- dump date 20140619_125327 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 416870000001 SEQ_END SEQ_END NC_009004.1 2529478 2529478 DR NC_009004.1; contig end 2529478..2529478 Lactococcus lactis subsp. cremoris MG1363 YP_001031366.1 CDS dnaA NC_009004.1 1 1365 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1365 Lactococcus lactis subsp. cremoris MG1363 4798589 YP_001031367.1 CDS dnaN NC_009004.1 1522 2664 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1522..2664 Lactococcus lactis subsp. cremoris MG1363 4798369 YP_001031368.1 CDS rexB NC_009004.1 2770 6069 D ATP-dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent helicase and DNA-dependent ATPase; High confidence in function and specificity; ATP-dependent nuclease subunit B 2770..6069 Lactococcus lactis subsp. cremoris MG1363 4798396 YP_001031369.1 CDS rexA NC_009004.1 6062 9673 D UvrD/REP helicase; High confidence in function and specificity; ATP-dependent nuclease subunit A 6062..9673 Lactococcus lactis subsp. cremoris MG1363 4797078 YP_001031370.1 CDS llmg_0005 NC_009004.1 9708 9908 D Bacterial protein of unknown function DUF951; hypothetical protein 9708..9908 Lactococcus lactis subsp. cremoris MG1363 4798206 YP_001031371.1 CDS llmg_0006 NC_009004.1 9916 10473 R Lambda repressor-like, DNA-binding, Helix-turn- helix; HTH-type transcriptional regulator complement(9916..10473) Lactococcus lactis subsp. cremoris MG1363 4796748 YP_001031372.1 CDS llmg_0007 NC_009004.1 10757 11872 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 10757..11872 Lactococcus lactis subsp. cremoris MG1363 4798155 YP_001031373.1 CDS llmg_0008 NC_009004.1 11984 12307 D DNA binding Helix-turn-helix motif; Conserved hypothetical protein; HTH-type transcriptional regulator 11984..12307 Lactococcus lactis subsp. cremoris MG1363 4797060 YP_001031374.1 CDS llmg_0009 NC_009004.1 12720 13421 D hypothetical protein 12720..13421 Lactococcus lactis subsp. cremoris MG1363 4798235 YP_001031375.1 CDS llmg_0010 NC_009004.1 13521 13712 D hypothetical protein 13521..13712 Lactococcus lactis subsp. cremoris MG1363 4799098 YP_001031376.1 CDS llmg_0011 NC_009004.1 13947 14432 D hypothetical protein 13947..14432 Lactococcus lactis subsp. cremoris MG1363 4797850 YP_001031377.1 CDS pth NC_009004.1 14436 15002 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 14436..15002 Lactococcus lactis subsp. cremoris MG1363 4797925 YP_001031378.1 CDS mfd NC_009004.1 15003 18545 D Transcription-repair coupling factor, CarD- like/TRCF domain; High confidence in function and specificity; transcription-repair coupling factor 15003..18545 Lactococcus lactis subsp. cremoris MG1363 4797443 YP_001031379.1 CDS llmg_0015 NC_009004.1 18862 19131 D RNA-binding S4; Conserved hypothetical protein; RNA binding protein 18862..19131 Lactococcus lactis subsp. cremoris MG1363 4798909 YP_001031380.1 CDS llmg_0016 NC_009004.1 19162 19536 D hypothetical protein 19162..19536 Lactococcus lactis subsp. cremoris MG1363 4796653 YP_001031381.1 CDS llmg_0017 NC_009004.1 19536 19859 D Nucleic acid-binding OB-fold, RNA binding S1 domain; Conserved hypothetical protein; hypothetical protein 19536..19859 Lactococcus lactis subsp. cremoris MG1363 4796747 YP_001031382.1 CDS llmg_0018 NC_009004.1 20021 21337 D COG: Beta-lactamase class A; Family membership; beta-lactamase A 20021..21337 Lactococcus lactis subsp. cremoris MG1363 4799110 YP_001031383.1 CDS mesJ NC_009004.1 21334 22602 D PP-loop family; High confidence in function and specificity; cell cycle protein mesJ 21334..22602 Lactococcus lactis subsp. cremoris MG1363 4796965 YP_001031384.1 CDS hpt NC_009004.1 22583 23134 D hypoxanthine phosphoribosyltransferase 22583..23134 Lactococcus lactis subsp. cremoris MG1363 4797593 YP_001031385.1 CDS ftsH NC_009004.1 23340 25427 D cell division protein 23340..25427 Lactococcus lactis subsp. cremoris MG1363 4798295 YP_001031386.1 CDS mtlA NC_009004.1 26494 28317 D [KO:K02799 K02800], PTS system, mannitol-specific IIBC component (EIIBC-Mtl), Phosphotransferase system, EIIC; High confidence in function and specificity; PTS system mannitol-specific transporter subunit IIBC 26494..28317 Lactococcus lactis subsp. cremoris MG1363 4799042 YP_001031387.1 CDS mtlR NC_009004.1 28377 30311 D PRD domain; High confidence in function and specificity; transcriptional regulator mtl operon mtlR 28377..30311 Lactococcus lactis subsp. cremoris MG1363 4797439 YP_001031388.1 CDS mtlF NC_009004.1 30358 30789 D PTS system, mannitol-specific IIABC component (EIIABC-Mtl), Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; High confidence in function and specificity; PTS system mannitol-specific transporter subunit IIA 30358..30789 Lactococcus lactis subsp. cremoris MG1363 4797482 YP_001031389.1 CDS mtlD NC_009004.1 30938 32104 D Mannitol-1-phosphate 5-dehydrogenase; High confidence in function and specificity; mannitol-1-phosphate 5-dehydrogenase 30938..32104 Lactococcus lactis subsp. cremoris MG1363 4797451 YP_001031390.1 CDS ps130 NC_009004.1 32974 33297 R hypothetical protein complement(32974..33297) Lactococcus lactis subsp. cremoris MG1363 4797446 YP_001031391.1 CDS ps129 NC_009004.1 33398 33778 R hypothetical protein complement(33398..33778) Lactococcus lactis subsp. cremoris MG1363 4798054 YP_001031392.1 CDS ps128 NC_009004.1 33806 34108 R nucleic acid binding motif, phage associated; hypothetical protein complement(33806..34108) Lactococcus lactis subsp. cremoris MG1363 4797973 YP_001031393.1 CDS ps127 NC_009004.1 34425 35006 R hypothetical protein complement(34425..35006) Lactococcus lactis subsp. cremoris MG1363 4797958 YP_001031394.1 CDS ps126 NC_009004.1 35242 36870 R Similar to ps105 from IL1403, Phage associated; Family membership; DNA primase complement(35242..36870) Lactococcus lactis subsp. cremoris MG1363 4796891 YP_001031395.1 CDS ps125 NC_009004.1 36881 37675 R phage DNA replication complement(36881..37675) Lactococcus lactis subsp. cremoris MG1363 4796946 YP_001031396.1 CDS ps124 NC_009004.1 37672 38007 R hypothetical protein complement(37672..38007) Lactococcus lactis subsp. cremoris MG1363 4798304 YP_001031397.1 CDS ps123 NC_009004.1 38004 38258 R hypothetical protein complement(38004..38258) Lactococcus lactis subsp. cremoris MG1363 4797243 YP_001031398.1 CDS ps122 NC_009004.1 38255 38494 R hypothetical protein complement(38255..38494) Lactococcus lactis subsp. cremoris MG1363 4798229 YP_001031399.1 CDS ps121 NC_009004.1 38536 38817 R DNA binding protein complement(38536..38817) Lactococcus lactis subsp. cremoris MG1363 4796976 YP_001031400.1 CDS ps120 NC_009004.1 38829 39254 R hypothetical protein complement(38829..39254) Lactococcus lactis subsp. cremoris MG1363 4798010 YP_001031401.1 CDS ps119 NC_009004.1 39259 39453 R Similar to ps113 of IL1403, Protein of unknown function (DUF1655), Phage associated; hypothetical protein complement(39259..39453) Lactococcus lactis subsp. cremoris MG1363 4796936 YP_001031402.1 CDS ps118 NC_009004.1 39569 39754 R Lambda repressor-like, DNA-binding, Helix-turn- helix; hypothetical protein complement(39569..39754) Lactococcus lactis subsp. cremoris MG1363 4796961 YP_001031403.1 CDS ps117 NC_009004.1 39837 40163 D hypothetical protein 39837..40163 Lactococcus lactis subsp. cremoris MG1363 4796925 YP_001031404.1 CDS ps116 NC_009004.1 40519 40734 R Lambda repressor-like, DNA-binding; phage repressor complement(40519..40734) Lactococcus lactis subsp. cremoris MG1363 4796585 YP_001031405.1 CDS ps115 NC_009004.1 40860 41282 D Family membership; phage repressor 40860..41282 Lactococcus lactis subsp. cremoris MG1363 4796897 YP_001031406.1 CDS ps114 NC_009004.1 41312 41866 D Conserved hypothetical protein; hypothetical protein 41312..41866 Lactococcus lactis subsp. cremoris MG1363 4796889 YP_001031407.1 CDS ps113 NC_009004.1 41977 42207 D Similar to ps117 from IL1403; hypothetical protein 41977..42207 Lactococcus lactis subsp. cremoris MG1363 4798656 YP_001031408.1 CDS ps112 NC_009004.1 42280 42474 D nucleic acid binding motif; hypothetical protein 42280..42474 Lactococcus lactis subsp. cremoris MG1363 4796923 YP_001031409.1 CDS ps111 NC_009004.1 43098 44423 D hypothetical protein 43098..44423 Lactococcus lactis subsp. cremoris MG1363 4796934 YP_001031410.1 CDS ps110 NC_009004.1 44505 44711 D hypothetical protein 44505..44711 Lactococcus lactis subsp. cremoris MG1363 4798167 YP_001031411.1 CDS ps109 NC_009004.1 45201 45443 D Similar to ps119 from IL1403; hypothetical protein 45201..45443 Lactococcus lactis subsp. cremoris MG1363 4796706 YP_001031412.1 CDS ps108 NC_009004.1 45579 45803 D Similar to ps120 from IL1403; Ps108 protein 45579..45803 Lactococcus lactis subsp. cremoris MG1363 4796604 YP_001031413.1 CDS tnp712 NC_009004.1 46467 47690 D Conserved hypothetical protein; transposase for insertion sequence element IS712A 46467..47690 Lactococcus lactis subsp. cremoris MG1363 4797130 YP_001031414.1 CDS llmg_0050 NC_009004.1 47702 48460 D IstB-like ATP-binding protein; Conserved hypothetical protein; transposase helper protein for IS712A 47702..48460 Lactococcus lactis subsp. cremoris MG1363 4798172 YP_001031415.1 CDS ps105 NC_009004.1 48562 48888 D hypothetical protein 48562..48888 Lactococcus lactis subsp. cremoris MG1363 4796599 YP_001031416.1 CDS ps104 NC_009004.1 49396 49533 D phage protein; hypothetical protein 49396..49533 Lactococcus lactis subsp. cremoris MG1363 4796690 YP_001031417.1 CDS ps103 NC_009004.1 49622 49786 D hypothetical protein 49622..49786 Lactococcus lactis subsp. cremoris MG1363 4796705 YP_001031418.1 CDS ps102 NC_009004.1 49908 50213 D Similar to lciA, Lactococcin A immunity protein; Conserved hypothetical protein; hypothetical protein 49908..50213 Lactococcus lactis subsp. cremoris MG1363 4797146 YP_001031419.1 CDS ps101 NC_009004.1 50463 51647 D DNA breaking-rejoining enzyme, catalytic core, Tyrosine recombinase xerD; Conserved hypothetical protein; phage integrase 50463..51647 Lactococcus lactis subsp. cremoris MG1363 4797037 YP_001031420.1 CDS llmg_0056 NC_009004.1 52156 52938 R Bacterial protein of unknown function DUF915; Family membership; hypothetical protein complement(52156..52938) Lactococcus lactis subsp. cremoris MG1363 4796957 YP_001031421.1 CDS llmg_0057 NC_009004.1 53631 53996 D hypothetical protein 53631..53996 Lactococcus lactis subsp. cremoris MG1363 4796648 YP_001031422.1 CDS llmg_0059 NC_009004.1 54401 54892 D hypothetical protein 54401..54892 Lactococcus lactis subsp. cremoris MG1363 4798185 YP_001031423.1 CDS llmg_0060 NC_009004.1 55405 55563 D hypothetical protein 55405..55563 Lactococcus lactis subsp. cremoris MG1363 4796637 YP_001031424.1 CDS llmg_0061 NC_009004.1 55905 56453 D GCN5-related N-acetyltransferase; Function unclear; acetyltransferase 55905..56453 Lactococcus lactis subsp. cremoris MG1363 4799096 YP_001031425.1 CDS llmg_0062 NC_009004.1 56574 56777 D hypothetical protein 56574..56777 Lactococcus lactis subsp. cremoris MG1363 4798950 YP_001031426.1 CDS llmg_0063 NC_009004.1 56870 58492 R Sulfate transporter family, sulP: sulfate permease; Family membership; sulfate transporter complement(56870..58492) Lactococcus lactis subsp. cremoris MG1363 4798957 YP_001031427.1 CDS tnp905 NC_009004.1 58702 59877 R High confidence in function and specificity; transposase for insertion sequence element IS905A complement(58702..59877) Lactococcus lactis subsp. cremoris MG1363 4798783 YP_001031428.1 CDS llmg_0065 NC_009004.1 60023 60544 D Amino-acid acetyltransferase, GCN5-related N- acetyltransferase; Family membership; GNAT family acetyltransferase 60023..60544 Lactococcus lactis subsp. cremoris MG1363 4798247 YP_001031429.1 CDS araT NC_009004.1 60873 62048 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 60873..62048 Lactococcus lactis subsp. cremoris MG1363 4796883 YP_001031430.1 CDS recO NC_009004.1 62146 62901 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 62146..62901 Lactococcus lactis subsp. cremoris MG1363 4797012 YP_001031431.1 CDS llmg_0069 NC_009004.1 63015 63896 D RGG_Cterm: transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Conserved hypothetical protein; HTH-type transcriptional regulator 63015..63896 Lactococcus lactis subsp. cremoris MG1363 4798205 YP_001031432.1 CDS llmg_0070 NC_009004.1 64007 65242 D Major facilitator superfamily MFS_1; Family membership; permease 64007..65242 Lactococcus lactis subsp. cremoris MG1363 4797031 YP_001031433.1 CDS pdhD NC_009004.1 65273 66691 R E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase complement(65273..66691) Lactococcus lactis subsp. cremoris MG1363 4798159 YP_001031434.1 CDS pdhC NC_009004.1 66910 68502 R Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, PDHac_trf_long: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; High confidence in function and specificity; pyruvate dehydrogenase complex E2 component complement(66910..68502) Lactococcus lactis subsp. cremoris MG1363 4798127 YP_001031435.1 CDS pdhB NC_009004.1 68495 69475 R 1-deoxy-D-xylulose-5-phosphate synthase (DXP synthase); High confidence in function and specificity; pyruvate dehydrogenase E1 component beta subunit complement(68495..69475) Lactococcus lactis subsp. cremoris MG1363 4798128 YP_001031436.1 CDS pdhA NC_009004.1 69478 70602 R pyruvate dehydrogenase E1 component alpha subunit complement(69478..70602) Lactococcus lactis subsp. cremoris MG1363 4798130 YP_001031437.1 CDS lplL NC_009004.1 70691 71692 R Lipoyltransferase and lipoate-protein ligase; High confidence in function and specificity; lipoate-protein ligase complement(70691..71692) Lactococcus lactis subsp. cremoris MG1363 4798148 YP_001031438.1 CDS llmg_0076 NC_009004.1 71885 72739 R High confidence in function and specificity; glycerophosphodiester phosphodiesterase complement(71885..72739) Lactococcus lactis subsp. cremoris MG1363 4796665 YP_001031439.1 CDS llmg_0077 NC_009004.1 72818 73468 R Metal-dependent phosphohydrolase, HD region; Family membership; phosphohydrolase complement(72818..73468) Lactococcus lactis subsp. cremoris MG1363 4797453 YP_001031440.1 CDS llmg_0078 NC_009004.1 73518 73844 R hypothetical protein complement(73518..73844) Lactococcus lactis subsp. cremoris MG1363 4797069 YP_001031441.1 CDS trpS NC_009004.1 73937 74962 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(73937..74962) Lactococcus lactis subsp. cremoris MG1363 4796978 YP_001031442.1 CDS osmC NC_009004.1 75461 75898 D OsmC-like protein; High confidence in function and specificity; osmotically inducible protein C 75461..75898 Lactococcus lactis subsp. cremoris MG1363 4798232 YP_001031443.1 CDS llmg_0081 NC_009004.1 76060 77373 D Amino acid permease-associated region; Function unclear; amino-acid permease 76060..77373 Lactococcus lactis subsp. cremoris MG1363 4799083 YP_001031444.1 CDS llmg_0082 NC_009004.1 77433 77783 D hypothetical protein 77433..77783 Lactococcus lactis subsp. cremoris MG1363 4798306 YP_001031445.1 CDS plsX NC_009004.1 77843 78838 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX complement(77843..78838) Lactococcus lactis subsp. cremoris MG1363 4798294 YP_001031446.1 CDS llmg_0084 NC_009004.1 78941 79753 R Cof-subfamily: Cof-like hydrolase; Family membership; hydrolase complement(78941..79753) Lactococcus lactis subsp. cremoris MG1363 4797072 YP_001031447.1 CDS llmg_0085 NC_009004.1 80129 81766 R ABC transporter related; Specificity unclear; ABC transporter ATP-binding protein complement(80129..81766) Lactococcus lactis subsp. cremoris MG1363 4798289 YP_001031448.1 CDS llmg_0086 NC_009004.1 82266 82520 D yiaA/B two helix domain; Conserved hypothetical protein; hypothetical protein 82266..82520 Lactococcus lactis subsp. cremoris MG1363 4796907 YP_001031449.1 CDS llmg_0087 NC_009004.1 82640 83464 R homology to 3-oxoacyl-[acyl-carrier-protein] reductase, Short-chain dehydrogenase/reductase SDR; Function unclear; short-chain type dehydrogenase complement(82640..83464) Lactococcus lactis subsp. cremoris MG1363 4797356 YP_001031450.1 CDS llmg_0088 NC_009004.1 83680 84249 D Conserved hypothetical protein; hypothetical protein 83680..84249 Lactococcus lactis subsp. cremoris MG1363 4797349 YP_001031451.1 CDS llmg_0089 NC_009004.1 85125 85706 R High confidence in function and specificity; HTH-type transcriptional regulator complement(85125..85706) Lactococcus lactis subsp. cremoris MG1363 4797521 YP_001031452.1 CDS llmg_0090 NC_009004.1 85894 86376 R Region start changed from 86382 to 86376 (-6 bases); hypothetical protein complement(85894..86376) Lactococcus lactis subsp. cremoris MG1363 4797318 YP_001031453.1 CDS cysD NC_009004.1 86633 87913 R OAH_OAS_sulfhy: O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase, Cystathionine beta-lyases/cystathionine gamma-synthases; High confidence in function and specificity; O-acetylhomoserine sulfhydrylase complement(86633..87913) Lactococcus lactis subsp. cremoris MG1363 4797283 YP_001031454.1 CDS llmg_0092 NC_009004.1 88166 88999 R Short-chain dehydrogenase/reductase SDR, homology to 3-oxoacyl-[acyl-carrier-protein] reductase; Function unclear; short-chain type dehydrogenase complement(88166..88999) Lactococcus lactis subsp. cremoris MG1363 4798863 YP_001031455.1 CDS llmg_0093 NC_009004.1 89403 89870 D Universal stress protein family; Conserved hypothetical protein; hypothetical protein 89403..89870 Lactococcus lactis subsp. cremoris MG1363 4797265 YP_001031456.1 CDS llmg_0094 NC_009004.1 89996 90193 D hypothetical protein 89996..90193 Lactococcus lactis subsp. cremoris MG1363 4797253 YP_001031457.1 CDS llmg_0095 NC_009004.1 90229 90849 D Esterase/lipase/thioesterase; esterase 90229..90849 Lactococcus lactis subsp. cremoris MG1363 4797358 YP_001031458.1 CDS llmg_0096 NC_009004.1 90917 92086 D Family membership; glyoxylase 90917..92086 Lactococcus lactis subsp. cremoris MG1363 4797820 YP_001031459.1 CDS llmg_0097 NC_009004.1 92097 92687 D contains FMN-binding split barrel domain; Function unclear; flavoprotein oxygenase 92097..92687 Lactococcus lactis subsp. cremoris MG1363 4798000 YP_001031460.1 CDS rpmG NC_009004.1 92769 92918 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(92769..92918) Lactococcus lactis subsp. cremoris MG1363 4798430 YP_001031461.1 CDS rpmF NC_009004.1 92948 93121 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(92948..93121) Lactococcus lactis subsp. cremoris MG1363 4799008 YP_001031462.1 CDS cadA NC_009004.1 93484 95265 D High confidence in function and specificity; cation-transporting ATPase 93484..95265 Lactococcus lactis subsp. cremoris MG1363 4799007 YP_001031463.1 CDS llmg_0101 NC_009004.1 95452 96300 D Conserved hypothetical protein; hypothetical protein 95452..96300 Lactococcus lactis subsp. cremoris MG1363 4797729 YP_001031464.1 CDS parA NC_009004.1 96310 97095 R ParB-like partition protein, ParB-like nuclease domain; High confidence in function and specificity; chromosome partitioning protein parA complement(96310..97095) Lactococcus lactis subsp. cremoris MG1363 4798323 YP_001031465.1 CDS cshA NC_009004.1 97150 98409 R High confidence in function and specificity; recombination factor protein RarA complement(97150..98409) Lactococcus lactis subsp. cremoris MG1363 4798774 YP_001031466.1 CDS llmg_0104 NC_009004.1 98453 98995 R GCN5-related N-acetyltransferase, Acetyltransferase (GNAT) family; High confidence in function and specificity; acetyltransferase complement(98453..98995) Lactococcus lactis subsp. cremoris MG1363 4798818 YP_001031467.1 CDS llmg_0105 NC_009004.1 99114 99581 D hypothetical protein 99114..99581 Lactococcus lactis subsp. cremoris MG1363 4797804 YP_001031468.1 CDS llmg_0106 NC_009004.1 99611 101164 D ABC transporter related; Family membership; ABC transporter ATP-binding protein 99611..101164 Lactococcus lactis subsp. cremoris MG1363 4798069 YP_001031469.1 CDS llmg_0107 NC_009004.1 101239 101523 D hypothetical protein 101239..101523 Lactococcus lactis subsp. cremoris MG1363 4796797 YP_001031470.1 CDS llmg_0108 NC_009004.1 101605 102297 D S-adenosylmethionine-dependent methyltransferase, SAM (and some other nucleotide) binding motif; Family membership; S-adenosylmethionine-dependent methyltransferase 101605..102297 Lactococcus lactis subsp. cremoris MG1363 4797514 YP_001031471.1 CDS llmg_0109 NC_009004.1 102281 102772 D hypothetical protein 102281..102772 Lactococcus lactis subsp. cremoris MG1363 4797501 YP_001031472.1 CDS prmA NC_009004.1 102785 103738 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 102785..103738 Lactococcus lactis subsp. cremoris MG1363 4797609 YP_001031473.1 CDS llmg_0111 NC_009004.1 103858 104610 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 103858..104610 Lactococcus lactis subsp. cremoris MG1363 4798532 YP_001031474.1 CDS llmg_0112 NC_009004.1 104640 105596 D Polysaccharide deacetylase, Signal peptide and one TMH; Family membership; xylanase/chitin deacetylase 104640..105596 Lactococcus lactis subsp. cremoris MG1363 4797449 YP_001031475.1 CDS relA NC_009004.1 105797 108019 D guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase ((ppGpp)ase) (Penta-phosphate guanosine-3'- pyrophosphohydrolase); High confidence in function and specificity; GTP pyrophosphokinase 105797..108019 Lactococcus lactis subsp. cremoris MG1363 4797906 YP_001031476.1 CDS llmg_0114 NC_009004.1 108034 108969 R Glycosyl transferase, family 2; Function unclear; glycosyl transferase family protein complement(108034..108969) Lactococcus lactis subsp. cremoris MG1363 4797043 YP_001031477.1 CDS dtd NC_009004.1 109228 109683 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 109228..109683 Lactococcus lactis subsp. cremoris MG1363 4798597 YP_001031478.1 CDS llmg_0116 NC_009004.1 109676 110680 D Protein of unknown function DUF1211; hypothetical protein 109676..110680 Lactococcus lactis subsp. cremoris MG1363 4798384 YP_001031479.1 CDS llmg_0117 NC_009004.1 110683 111306 D hydrolase (HAD superfamily) (PFAM), Haloacid dehalogenase-like hydrolase; Conserved hypothetical protein; hypothetical protein 110683..111306 Lactococcus lactis subsp. cremoris MG1363 4798739 YP_001031480.1 CDS ctrA NC_009004.1 111440 112837 D Amino acid permease-associated region, COG: Amino acid transporters, PFAM: Amino acid permease, 2A0306: amino acid transporter; Conserved hypothetical protein; amino-acid transporter 111440..112837 Lactococcus lactis subsp. cremoris MG1363 4797605 YP_001031481.1 CDS llmg_0119 NC_009004.1 112986 113648 D acyltransferase 112986..113648 Lactococcus lactis subsp. cremoris MG1363 4798841 YP_001031482.1 CDS rmaD NC_009004.1 113679 114197 R Bacterial regulatory protein, MarR; Conserved hypothetical protein; MarR family transcriptional regulator complement(113679..114197) Lactococcus lactis subsp. cremoris MG1363 4798609 YP_001031483.1 CDS llmg_0121 NC_009004.1 114407 114697 D transposase helper protein for IS904; hypothetical protein 114407..114697 Lactococcus lactis subsp. cremoris MG1363 4797590 YP_001031484.1 CDS tnp904 NC_009004.1 114793 115554 D Integrase, catalytic region; Conserved hypothetical protein; transposase for insertion sequence element IS904A 114793..115554 Lactococcus lactis subsp. cremoris MG1363 4798443 YP_001031485.1 CDS acpD NC_009004.1 115603 116247 R acyl carrier protein phosphodiesterase, fatty acid and phospholipid metabolism; High confidence in function and specificity; acyl carrier protein complement(115603..116247) Lactococcus lactis subsp. cremoris MG1363 4798339 YP_001031486.1 CDS secA NC_009004.1 116422 119019 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 116422..119019 Lactococcus lactis subsp. cremoris MG1363 4798902 YP_001031487.1 CDS aroF NC_009004.1 119149 120186 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 119149..120186 Lactococcus lactis subsp. cremoris MG1363 4797238 YP_001031488.1 CDS ptsH NC_009004.1 120435 120701 D Phosphocarrier protein HPr (Histidine-containing protein)., PTS HPr component phosphorylation site, PTS_HPr_family: phosphocarrier protein HPr; High confidence in function and specificity; phosphocarrier protein HPr 120435..120701 Lactococcus lactis subsp. cremoris MG1363 4798281 YP_001031489.1 CDS ptsI NC_009004.1 120704 122431 D Phosphoenolpyruvate-protein phosphotransferase , Phosphotransferase system, enzyme I, PEP-utilising enzyme, TIM barrel domain, PTS_I_fam: phosphoenolpyruvate-protein phosphotransferase; High confidence in function and specificity; phosphoenolpyruvate-protein phosphotransferase 120704..122431 Lactococcus lactis subsp. cremoris MG1363 4797692 YP_001031490.1 CDS llmg_0128 NC_009004.1 123002 123301 R hypothetical protein complement(123002..123301) Lactococcus lactis subsp. cremoris MG1363 4797702 YP_001031491.1 CDS llmg_0129 NC_009004.1 123407 123694 D hypothetical protein 123407..123694 Lactococcus lactis subsp. cremoris MG1363 4796836 YP_001031492.1 CDS llmg_0130 NC_009004.1 123974 124918 R Esterase/lipase/thioesterase; Conserved hypothetical protein; hypothetical protein complement(123974..124918) Lactococcus lactis subsp. cremoris MG1363 4796573 YP_001031493.1 CDS llmg_0131 NC_009004.1 125070 126458 D hypothetical protein 125070..126458 Lactococcus lactis subsp. cremoris MG1363 4797180 YP_001031494.1 CDS sugE NC_009004.1 126644 126964 D EmrE protein (Methyl viologen resistance protein C) , (Ethidium resistance protein); Specificity unclear; small multidrug resistance protein 126644..126964 Lactococcus lactis subsp. cremoris MG1363 4798389 YP_001031495.1 CDS blt NC_009004.1 127087 128250 D Multidrug resistance protein 1 (Multidrug-efflux transporter 1)., General substrate transporter Major Facilitator Superfamily, 2_A_01_02: Multidrug resistance protein; High confidence in function and specificity; multidrug resistance protein 127087..128250 Lactococcus lactis subsp. cremoris MG1363 4798599 YP_001031496.1 CDS llmg_0134 NC_009004.1 128554 129504 D Glycosyl transferase, family 2, Bactoprenol glucosyl transferase; High confidence in function and specificity; bactoprenol glucosyl transferase 128554..129504 Lactococcus lactis subsp. cremoris MG1363 4798850 YP_001031497.1 CDS llmg_0135 NC_009004.1 129488 130723 D predicted transmembrane protein, multiple transmembrane segments; hypothetical protein 129488..130723 Lactococcus lactis subsp. cremoris MG1363 4798373 YP_001031498.1 CDS llmg_0136 NC_009004.1 131117 131638 D ATP-binding region, ATPase-like; Conserved hypothetical protein; sensor protein kinase 131117..131638 Lactococcus lactis subsp. cremoris MG1363 4798368 YP_001031499.1 CDS llmg_0137 NC_009004.1 131705 133078 D Permeases of the major facilitator superfamily, von Willebrand factor, type A; permease 131705..133078 Lactococcus lactis subsp. cremoris MG1363 4798882 YP_001031500.1 CDS argG NC_009004.1 134045 135241 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 134045..135241 Lactococcus lactis subsp. cremoris MG1363 4796764 YP_001031501.1 CDS argH NC_009004.1 135270 136649 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 135270..136649 Lactococcus lactis subsp. cremoris MG1363 4796894 YP_001031502.1 CDS pmrB NC_009004.1 136666 137811 R Multidrug resistance protein, Integral membrane protein; Conserved hypothetical protein; multidrug resistance efflux pump complement(136666..137811) Lactococcus lactis subsp. cremoris MG1363 4799106 YP_001031503.1 CDS llmg_0141 NC_009004.1 138054 138629 D Tetracyclin repressor-like, C-terminal; Conserved hypothetical protein; transcriptional regulator 138054..138629 Lactococcus lactis subsp. cremoris MG1363 4797842 YP_001031504.1 CDS rnpA NC_009004.1 138786 139139 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 138786..139139 Lactococcus lactis subsp. cremoris MG1363 4798919 YP_001031505.1 CDS llmg_0143 NC_009004.1 139136 139945 D Region start changed from 139163 to 139136 (27 bases); preprotein translocase subunit 139136..139945 Lactococcus lactis subsp. cremoris MG1363 4798421 YP_001031506.1 CDS llmg_0144 NC_009004.1 140033 140947 D Single-stranded nucleic acid binding , Domain R3H and KH; Conserved hypothetical protein; ORF1; hypothetical protein 140033..140947 Lactococcus lactis subsp. cremoris MG1363 4798762 YP_001031507.1 CDS rpmH NC_009004.1 141079 141213 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 141079..141213 Lactococcus lactis subsp. cremoris MG1363 4798551 YP_001031508.1 CDS llmg_0146 NC_009004.1 141388 142299 D Aldo/keto reductase, Aldo/keto reductase; High confidence in function and specificity; aryl-alcohol dehydrogenase 141388..142299 Lactococcus lactis subsp. cremoris MG1363 4798806 YP_001031509.1 CDS llmg_0147 NC_009004.1 142360 142620 D lambda repressor-like, DNA-binding 142360..142620 Lactococcus lactis subsp. cremoris MG1363 4796824 YP_001031510.1 CDS llmg_0148 NC_009004.1 142809 143009 D hypothetical protein 142809..143009 Lactococcus lactis subsp. cremoris MG1363 4796587 YP_001031511.1 CDS llmg_0149 NC_009004.1 143092 143772 D Abortive infection protein, CAAX amino terminal protease; hypothetical protein 143092..143772 Lactococcus lactis subsp. cremoris MG1363 4797836 YP_001031512.1 CDS llmg_0150 NC_009004.1 144067 144333 D Conserved hypothetical protein; hypothetical protein 144067..144333 Lactococcus lactis subsp. cremoris MG1363 4797869 YP_001031513.1 CDS llmg_0151 NC_009004.1 144333 144764 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 144333..144764 Lactococcus lactis subsp. cremoris MG1363 4797916 YP_001031514.1 CDS llmg_0152 NC_009004.1 144865 145188 D hypothetical protein 144865..145188 Lactococcus lactis subsp. cremoris MG1363 4797944 YP_001031515.1 CDS llmg_0153 NC_009004.1 145218 145769 R Predicted integral membrane protein; hypothetical protein complement(145218..145769) Lactococcus lactis subsp. cremoris MG1363 4797276 YP_001031516.1 CDS cbr NC_009004.1 145859 146644 R 3-oxoacyl-[acyl-carrier-protein] reductase , Short- chain dehydrogenase/reductase SDR\, Fatty acid biosynthesis pathway; High confidence in function and specificity; carbonyl reductase complement(145859..146644) Lactococcus lactis subsp. cremoris MG1363 4797327 YP_001031517.1 CDS llmg_0155 NC_009004.1 146664 146975 R hypothetical protein complement(146664..146975) Lactococcus lactis subsp. cremoris MG1363 4797763 YP_001031518.1 CDS dltE NC_009004.1 146985 147770 R 3-oxoacyl-[acyl-carrier-protein] reductase, Short- chain dehydrogenase/reductase SDR, Fatty acid biosynthesis pathway; High confidence in function and specificity; oxidoreductase dltE complement(146985..147770) Lactococcus lactis subsp. cremoris MG1363 4797310 YP_001031519.1 CDS tetR NC_009004.1 147888 148433 D Homeodomain-like, Bacterial regulatory proteins, tetR family; transcriptional regulator 147888..148433 Lactococcus lactis subsp. cremoris MG1363 4798364 YP_001031520.1 CDS glgB NC_009004.1 148498 150441 R 1,4-alpha-glucan branching enzyme , Glycogen branching enzyme, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6- glucosyl- transferase, Alpha amylase, catalytic subdomain, Isoamylase N-terminal domain, branching_enzym: 1,4-alpha- glucan branching enzyme; High confidence in function and specificity; GlgB protein complement(148498..150441) Lactococcus lactis subsp. cremoris MG1363 4797090 YP_001031521.1 CDS llmg_0159 NC_009004.1 150562 150882 R hypothetical protein complement(150562..150882) Lactococcus lactis subsp. cremoris MG1363 4798283 YP_001031522.1 CDS llmg_0160 NC_009004.1 151041 151679 D FMN-dependent nitroreductase (Dihydropteridine reductase); Conserved hypothetical protein; oxygen-insensitive NAD(P)H nitroreductase 151041..151679 Lactococcus lactis subsp. cremoris MG1363 4797875 YP_001031523.1 CDS llmg_0161 NC_009004.1 151722 152270 D Homeodomain-like, Bacterial regulatory proteins, tetR family; Conserved hypothetical protein; HTH-type transcriptional regulator 151722..152270 Lactococcus lactis subsp. cremoris MG1363 4797195 YP_001031524.1 CDS llmg_0162 NC_009004.1 152726 154126 D Bacterial adhesion, Collagen binding domain, Predicted Signal sequence; hypothetical protein 152726..154126 Lactococcus lactis subsp. cremoris MG1363 4798057 YP_001031525.1 CDS epsR NC_009004.1 154139 154453 D Lambda repressor-like, DNA-binding; transcriptional regulator 154139..154453 Lactococcus lactis subsp. cremoris MG1363 4798034 YP_001031526.1 CDS tgt NC_009004.1 154740 155888 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(154740..155888) Lactococcus lactis subsp. cremoris MG1363 4796935 YP_001031527.1 CDS llmg_0165 NC_009004.1 156088 156777 D hypothetical protein 156088..156777 Lactococcus lactis subsp. cremoris MG1363 4796914 YP_001031528.1 CDS llmg_0167 NC_009004.1 158195 158632 R CoA binding domain; hypothetical protein complement(158195..158632) Lactococcus lactis subsp. cremoris MG1363 4797496 YP_001031529.1 CDS llmg_0168 NC_009004.1 158769 159554 D DNA/RNA non-specific endonuclease; High confidence in function and specificity; deoxyribonuclease 158769..159554 Lactococcus lactis subsp. cremoris MG1363 4798433 YP_001031530.1 CDS llmg_0169 NC_009004.1 159944 160183 D Transmembrane protein; hypothetical protein 159944..160183 Lactococcus lactis subsp. cremoris MG1363 4797830 YP_001031531.1 CDS llmg_0170 NC_009004.1 160381 161961 D Heme/copper-type cytochrome/quinol oxidases, subunit 1, COG: 0843; hypothetical protein 160381..161961 Lactococcus lactis subsp. cremoris MG1363 4798444 YP_001031532.1 CDS aspC NC_009004.1 162090 163304 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 162090..163304 Lactococcus lactis subsp. cremoris MG1363 4797966 YP_001031533.1 CDS codY NC_009004.1 163457 164245 D CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 163457..164245 Lactococcus lactis subsp. cremoris MG1363 4797198 YP_001031534.1 CDS llmg_0173 NC_009004.1 164352 164471 D hypothetical protein 164352..164471 Lactococcus lactis subsp. cremoris MG1363 4796783 YP_001031535.1 CDS gatC NC_009004.1 164523 164828 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 164523..164828 Lactococcus lactis subsp. cremoris MG1363 4797604 YP_001031536.1 CDS gatA NC_009004.1 164828 166288 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 164828..166288 Lactococcus lactis subsp. cremoris MG1363 4796605 YP_001031537.1 CDS gatB NC_009004.1 166313 167746 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 166313..167746 Lactococcus lactis subsp. cremoris MG1363 4796630 YP_001031538.1 CDS llmg_0177 NC_009004.1 167870 169369 D Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases, Similar to GatA; High confidence in function and specificity; amidase 167870..169369 Lactococcus lactis subsp. cremoris MG1363 4797424 YP_001031539.1 CDS dinF NC_009004.1 169436 170776 R cation efflux protein (); High confidence in function and specificity; damage-inducible protein DinF complement(169436..170776) Lactococcus lactis subsp. cremoris MG1363 4798064 YP_001031540.1 CDS cspE NC_009004.1 170956 171153 R Cold-shock protein, DNA-binding; Conserved hypothetical protein; cold shock-like protein cspE complement(170956..171153) Lactococcus lactis subsp. cremoris MG1363 4798908 YP_001031541.1 CDS llmg_0181 NC_009004.1 171272 171805 D High confidence in function and specificity; 5-formyltetrahydrofolate cyclo-ligase 171272..171805 Lactococcus lactis subsp. cremoris MG1363 4798836 YP_001031542.1 CDS llmg_0182 NC_009004.1 171795 172487 D Rhomboid-like protein; High confidence in function and specificity; rhomboid-related protein 1 171795..172487 Lactococcus lactis subsp. cremoris MG1363 4796603 YP_001031543.1 CDS llmg_0183 NC_009004.1 172586 173017 D Conserved hypothetical protein; hypothetical protein 172586..173017 Lactococcus lactis subsp. cremoris MG1363 4798357 YP_001031544.1 CDS llmg_0184 NC_009004.1 173038 173418 D Lactoylglutathione lyase , Methylglyoxalase; Aldoketomutase; Glyoxalase I, Ketone-aldehyde mutase; High confidence in function and specificity; lactoylglutathione lyase 173038..173418 Lactococcus lactis subsp. cremoris MG1363 4797141 YP_001031545.1 CDS llmg_0185 NC_009004.1 173529 174581 D Predicted acetyltransferase, Eis type; High confidence in function and specificity; acetyltransferase 173529..174581 Lactococcus lactis subsp. cremoris MG1363 4796675 YP_001031546.1 CDS llmg_0186 NC_009004.1 174930 176021 D hypothetical protein 174930..176021 Lactococcus lactis subsp. cremoris MG1363 4796663 YP_001031547.1 CDS celB NC_009004.1 176121 177605 D PTS system, lichenan-specific IIC component , Phosphotransferase enzyme II, C component; High confidence in function and specificity; cellobiose-specific PTS system IIC component 176121..177605 Lactococcus lactis subsp. cremoris MG1363 4796591 YP_001031548.1 CDS llmg_0188 NC_009004.1 177731 177937 D hypothetical protein 177731..177937 Lactococcus lactis subsp. cremoris MG1363 4796950 YP_001031549.1 CDS llmg_0189 NC_009004.1 177934 178128 D hypothetical protein 177934..178128 Lactococcus lactis subsp. cremoris MG1363 4796997 YP_001031550.1 CDS bglS NC_009004.1 178257 179693 D Beta-glucosidase , Gentiobiase; Cellobiase; Beta-D- glucoside glucohydrolase; Amygdalase, Glycoside hydrolase, family 1; High confidence in function and specificity; Beta-glucosidase A 178257..179693 Lactococcus lactis subsp. cremoris MG1363 4798653 YP_001031551.1 CDS dut NC_009004.1 179759 180211 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 179759..180211 Lactococcus lactis subsp. cremoris MG1363 4797360 YP_001031552.1 CDS llmg_0192 NC_009004.1 180304 181644 D 5'-nucleotidase precursor , Phosphoesterase-related protein; High confidence in function and specificity; 5'-nucleotidase 180304..181644 Lactococcus lactis subsp. cremoris MG1363 4796772 YP_001031553.1 CDS llmg_0193 NC_009004.1 181659 182426 D hypothetical protein 181659..182426 Lactococcus lactis subsp. cremoris MG1363 4798560 YP_001031554.1 CDS llmg_0194 NC_009004.1 182618 183715 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 182618..183715 Lactococcus lactis subsp. cremoris MG1363 4798169 YP_001031555.1 CDS llmg_0195 NC_009004.1 183963 184574 D Oxygen-insensitive NAD(P)H nitroreductase; High confidence in function and specificity; NADH dehydrogenase 183963..184574 Lactococcus lactis subsp. cremoris MG1363 4796943 YP_001031556.1 CDS llmg_0196 NC_009004.1 184725 185705 D Region start changed from 184692 to 184725 (-33 bases); prenyl transferase 184725..185705 Lactococcus lactis subsp. cremoris MG1363 4798174 YP_001031557.1 CDS menA NC_009004.1 185902 186807 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 185902..186807 Lactococcus lactis subsp. cremoris MG1363 4797073 YP_001031558.1 CDS llmg_0198 NC_009004.1 186846 187973 R Abortive infection protein; hypothetical protein complement(186846..187973) Lactococcus lactis subsp. cremoris MG1363 4798355 YP_001031559.1 CDS feoB NC_009004.1 188447 190522 R feoB: ferrous iron transport protein B; Conserved hypothetical protein; ferrous iron transport protein B complement(188447..190522) Lactococcus lactis subsp. cremoris MG1363 4797135 YP_001031560.1 CDS feoA NC_009004.1 190625 191101 R Transcriptional repressor, C-terminal, FeoA domain; Conserved hypothetical protein; ferrous iron transport protein A complement(190625..191101) Lactococcus lactis subsp. cremoris MG1363 4797105 YP_001031561.1 CDS msrB NC_009004.1 191414 191842 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 191414..191842 Lactococcus lactis subsp. cremoris MG1363 4798539 YP_001031562.1 CDS llmg_0202 NC_009004.1 191970 193634 R Conserved hypothetical protein; kinase related to dihydroxyacetone kinase complement(191970..193634) Lactococcus lactis subsp. cremoris MG1363 4797930 YP_001031563.1 CDS llmg_0203 NC_009004.1 193634 194002 R hypothetical protein complement(193634..194002) Lactococcus lactis subsp. cremoris MG1363 4797041 YP_001031564.1 CDS rpmB NC_009004.1 194276 194470 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(194276..194470) Lactococcus lactis subsp. cremoris MG1363 4797103 YP_001031565.1 CDS llmg_0205 NC_009004.1 194607 195266 D Membrane protein of unknown function; hypothetical protein 194607..195266 Lactococcus lactis subsp. cremoris MG1363 4799061 YP_001031566.1 CDS rmlA NC_009004.1 195461 196330 D Glucose-1-phosphate thymidylyltransferase 1, dTDP- glucose synthase 1; dTDP-glucose pyrophosphorylase 1; High confidence in function and specificity; glucose-1-phosphate thymidylyltransferase 195461..196330 Lactococcus lactis subsp. cremoris MG1363 4796994 YP_001031567.1 CDS rmlC NC_009004.1 196330 196923 D dTDP-4-dehydrorhamnose 3,5-epimerase, dTDP-4-keto-6- deoxyglucose 3,5-epimerase, dTDP-L-rhamnose synthetase; High confidence in function and specificity; dTDP-4-keto-6-deoxyglucose-3,5-epimerase 196330..196923 Lactococcus lactis subsp. cremoris MG1363 4797178 YP_001031568.1 CDS llmg_0208 NC_009004.1 196923 197177 D hypothetical protein 196923..197177 Lactococcus lactis subsp. cremoris MG1363 4797193 YP_001031569.1 CDS rmlB NC_009004.1 197217 198269 D dTDP-glucose 4,6-dehydratase 197217..198269 Lactococcus lactis subsp. cremoris MG1363 4796876 YP_001031570.1 CDS rmlD NC_009004.1 198457 199356 D Probable dTDP-4-dehydrorhamnose reductase, dTDP-4- keto- L-rhamnose reductase, rmlD: dTDP-4-dehydrorhamnose reductase; High confidence in function and specificity; dTDP-4-dehydrorhamnose reductase 198457..199356 Lactococcus lactis subsp. cremoris MG1363 4798414 YP_001031571.1 CDS rgpA NC_009004.1 199519 200727 D polysaccharide biosynthesis protein; High confidence in function and specificity; rhamnosyltransferase RgpA 199519..200727 Lactococcus lactis subsp. cremoris MG1363 4797874 YP_001031572.1 CDS rgpB NC_009004.1 200717 201658 D Glycosyl transferase, family 2, polysaccharide synthesis protein; High confidence in function and specificity; rhamnosyltransferase RgpB 200717..201658 Lactococcus lactis subsp. cremoris MG1363 4797088 YP_001031573.1 CDS rgpC NC_009004.1 201655 202464 D ABC-2 type transporter; Conserved hypothetical protein; capsule polysaccharide export inner-membrane protein RgpC 201655..202464 Lactococcus lactis subsp. cremoris MG1363 4796700 YP_001031574.1 CDS rgpD NC_009004.1 202479 203672 D High confidence in function and specificity; polysaccharide ABC transporter ATP-binding protein 202479..203672 Lactococcus lactis subsp. cremoris MG1363 4798493 YP_001031575.1 CDS llmg_0215 NC_009004.1 203650 205041 D Conserved hypothetical protein; hypothetical protein 203650..205041 Lactococcus lactis subsp. cremoris MG1363 4797077 YP_001031576.1 CDS rgpE NC_009004.1 205049 206005 D Glycosyl transferase, family 2; High confidence in function and specificity; glycosyltransferase RgpE 205049..206005 Lactococcus lactis subsp. cremoris MG1363 4796954 YP_001031577.1 CDS rgpF NC_009004.1 205995 207761 D Rhamnan synthesis protein F, polysaccharide biosynthesis protein; High confidence in function and specificity; alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 205995..207761 Lactococcus lactis subsp. cremoris MG1363 4796998 YP_001031578.1 CDS llmg_0218 NC_009004.1 207843 208580 D Glycosyl transferase, family 2; High confidence in function and specificity; glycosyl transferase family protein 207843..208580 Lactococcus lactis subsp. cremoris MG1363 4796898 YP_001031579.1 CDS llmg_0219 NC_009004.1 208580 208933 D hypothetical protein 208580..208933 Lactococcus lactis subsp. cremoris MG1363 4796881 YP_001031580.1 CDS llmg_0220 NC_009004.1 208969 209763 D Glycosyl transferase, family 2; Conserved hypothetical protein; glycosyl transferase family protein 208969..209763 Lactococcus lactis subsp. cremoris MG1363 4796874 YP_001031581.1 CDS llmg_0221 NC_009004.1 209769 210761 D Glycosyl transferase, family 2; Conserved hypothetical protein; glycosyl transferase family protein 209769..210761 Lactococcus lactis subsp. cremoris MG1363 4798173 YP_001031582.1 CDS wefC NC_009004.1 210754 211752 D hypothetical protein 210754..211752 Lactococcus lactis subsp. cremoris MG1363 4796766 YP_001031583.1 CDS llmg_0223 NC_009004.1 211819 212853 D Conserved hypothetical protein; hypothetical protein 211819..212853 Lactococcus lactis subsp. cremoris MG1363 4797953 YP_001031584.1 CDS glf1 NC_009004.1 212853 213983 D High confidence in function and specificity; Glf1 protein 212853..213983 Lactococcus lactis subsp. cremoris MG1363 4798554 YP_001031585.1 CDS rfbX NC_009004.1 213980 215398 D Polysaccharide biosynthesis protein; Family membership; O-antigen transporter 213980..215398 Lactococcus lactis subsp. cremoris MG1363 4798485 YP_001031586.1 CDS llmg_0226 NC_009004.1 215427 217226 D surface protein 215427..217226 Lactococcus lactis subsp. cremoris MG1363 4796944 YP_001031587.1 CDS llmg_0227 NC_009004.1 217228 218283 D hypothetical protein 217228..218283 Lactococcus lactis subsp. cremoris MG1363 4796681 YP_001031588.1 CDS llmg_0228 NC_009004.1 218280 218654 D hypothetical protein 218280..218654 Lactococcus lactis subsp. cremoris MG1363 4796985 YP_001031589.1 CDS llmg_0229 NC_009004.1 218798 220096 R Glycoside hydrolase, family 25; Family membership; hypothetical protein complement(218798..220096) Lactococcus lactis subsp. cremoris MG1363 4797064 YP_001031590.1 CDS guaB NC_009004.1 220476 221957 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 220476..221957 Lactococcus lactis subsp. cremoris MG1363 4797333 YP_001031591.1 CDS llmg_0231 NC_009004.1 222183 223328 D in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 222183..223328 Lactococcus lactis subsp. cremoris MG1363 4796854 YP_001031592.1 CDS llmg_0232 NC_009004.1 223423 223926 D Probable (di)nucleoside polyphosphate hydrolase., MutT/Nudix family protein; Family membership; hypothetical protein 223423..223926 Lactococcus lactis subsp. cremoris MG1363 4796742 YP_001031593.1 CDS hflX NC_009004.1 224009 225253 D GTP-binding protein, HSR1-related; High confidence in function and specificity; GTP-binding protein HflX 224009..225253 Lactococcus lactis subsp. cremoris MG1363 4798492 YP_001031594.1 CDS llmg_0234 NC_009004.1 225382 225708 R hypothetical protein complement(225382..225708) Lactococcus lactis subsp. cremoris MG1363 4797589 YP_001031595.1 CDS llmg_0235 NC_009004.1 225877 226191 D Protein of unknown function UPF0044, contains CRS1 / YhbY domain; hypothetical protein 225877..226191 Lactococcus lactis subsp. cremoris MG1363 4798196 YP_001031596.1 CDS nadD1 NC_009004.1 226266 226865 D TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase; High confidence in function and specificity; nicotinate-nucleotide adenylyltransferase 226266..226865 Lactococcus lactis subsp. cremoris MG1363 4797021 YP_001031597.1 CDS llmg_0237 NC_009004.1 226858 227448 D PF01966.9: Metal-dependent phosphohydrolase, HD subdomain, TIGR00488: conserved hypothetical protein TIGR00488; hydrolase 226858..227448 Lactococcus lactis subsp. cremoris MG1363 4798115 YP_001031598.1 CDS llmg_0238 NC_009004.1 227495 227926 D GCN5-related N-acetyltransferase; Family membership; hypothetical protein 227495..227926 Lactococcus lactis subsp. cremoris MG1363 4797067 YP_001031599.1 CDS llmg_0239 NC_009004.1 228093 228452 D Domain of unknown function DUF143, TIGR00090: iojap- related protein; hypothetical protein 228093..228452 Lactococcus lactis subsp. cremoris MG1363 4798209 YP_001031600.1 CDS llmg_0240 NC_009004.1 228552 229286 D contains SAM (and some other nucleotide) binding motif; hypothetical protein 228552..229286 Lactococcus lactis subsp. cremoris MG1363 4797110 YP_001031601.1 CDS llmg_0241 NC_009004.1 229336 230475 D Protein of unknown function DUF795; Family membership; hypothetical protein 229336..230475 Lactococcus lactis subsp. cremoris MG1363 4796928 YP_001031602.1 CDS llmg_0242 NC_009004.1 230628 231344 D PF01709.9: Protein of unknown function DUF28; hypothetical protein 230628..231344 Lactococcus lactis subsp. cremoris MG1363 4796983 YP_001031603.1 CDS ung NC_009004.1 232047 232706 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 232047..232706 Lactococcus lactis subsp. cremoris MG1363 4797500 YP_001031604.1 CDS llmg_0245 NC_009004.1 232743 233654 R Zinc-containing alcohol dehydrogenase superfamily; Family membership; zinc-binding dehydrogenase complement(232743..233654) Lactococcus lactis subsp. cremoris MG1363 4797173 YP_001031605.1 CDS llmg_0246 NC_009004.1 233677 234555 R hypothetical protein complement(233677..234555) Lactococcus lactis subsp. cremoris MG1363 4798496 YP_001031606.1 CDS llmg_0247 NC_009004.1 234577 235416 R Function unclear; UDP-glucose 4-epimerase complement(234577..235416) Lactococcus lactis subsp. cremoris MG1363 4797582 YP_001031607.1 CDS llmg_0248 NC_009004.1 235620 236165 D Function unclear; TetR family transcriptional regulator 235620..236165 Lactococcus lactis subsp. cremoris MG1363 4797557 YP_001031608.1 CDS llmg_0249 NC_009004.1 236277 237737 R Major facilitator superfamily; Family membership; transporter complement(236277..237737) Lactococcus lactis subsp. cremoris MG1363 4798039 YP_001031609.1 CDS rmeC NC_009004.1 237923 238294 D DNA binding HTH containing; Family membership; MerR family transcriptional regulator 237923..238294 Lactococcus lactis subsp. cremoris MG1363 4798312 YP_001031610.1 CDS rpsU NC_009004.1 238375 238551 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 238375..238551 Lactococcus lactis subsp. cremoris MG1363 4797824 YP_001031611.1 CDS llmg_0252 NC_009004.1 238659 239471 D Cof protein, HAD-SF-IIB: predicted HAD-superfamily hydrolase, subfamily IIB; Family membership; hypothetical protein 238659..239471 Lactococcus lactis subsp. cremoris MG1363 4797369 YP_001031612.1 CDS pgk NC_009004.1 239673 240869 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 239673..240869 Lactococcus lactis subsp. cremoris MG1363 4797899 YP_001031613.1 CDS hadL NC_009004.1 240927 241601 D (S)-2-haloacid dehalogenase (Halocarboxylic acid halidohydrolase), Haloacid dehalogenase, type II; High confidence in function and specificity; cryptic haloacid dehalogenase 1 240927..241601 Lactococcus lactis subsp. cremoris MG1363 4798385 YP_001031614.1 CDS dhaK NC_009004.1 241721 242707 D similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone; DhaKLM operon coactivator DhaQ 241721..242707 Lactococcus lactis subsp. cremoris MG1363 4797546 YP_001031615.1 CDS dhaM NC_009004.1 244314 244892 D Dihydroxyacetone kinase (Glycerone kinase) (DHA kinase), DAK2 domain; High confidence in function and specificity; dihydroxyacetone kinase DhaM 244314..244892 Lactococcus lactis subsp. cremoris MG1363 4798904 YP_001031616.1 CDS llmg_0258 NC_009004.1 244889 245260 D PF03610.4: PTS system fructose subfamily IIA component; hypothetical protein 244889..245260 Lactococcus lactis subsp. cremoris MG1363 4798906 YP_001031617.1 CDS pepDA NC_009004.1 245939 247321 R Peptidase U34; High confidence in function and specificity; PepDA protein complement(245939..247321) Lactococcus lactis subsp. cremoris MG1363 4798470 YP_001031618.1 CDS llmg_0262 NC_009004.1 248309 249451 D Specificity unclear; ABC transporter permease 248309..249451 Lactococcus lactis subsp. cremoris MG1363 4797511 YP_001031619.1 CDS llmg_0263 NC_009004.1 249574 250743 D PS50193: contains SAM (and some other nucleotide) binding motif; Family membership; methyltransferase 249574..250743 Lactococcus lactis subsp. cremoris MG1363 4797376 YP_001031620.1 CDS fbp NC_009004.1 250908 252830 D High confidence in function and specificity; fructose-bisphosphatase 250908..252830 Lactococcus lactis subsp. cremoris MG1363 4799147 YP_001031621.1 CDS llmg_0265 NC_009004.1 253062 254336 R TIGR00275: conserved hypothetical protein TIGR00275; flavoprotein complement(253062..254336) Lactococcus lactis subsp. cremoris MG1363 4796574 YP_001031622.1 CDS llmg_0266 NC_009004.1 254374 255204 D Protein of unknown function UPF0031; Family membership; sugar kinase 254374..255204 Lactococcus lactis subsp. cremoris MG1363 4799141 YP_001031623.1 CDS llmg_0267 NC_009004.1 255275 255688 D hypothetical protein 255275..255688 Lactococcus lactis subsp. cremoris MG1363 4798937 YP_001031624.1 CDS llmg_0268 NC_009004.1 255940 257721 D Specificity unclear; ABC transporter ATP-binding protein 255940..257721 Lactococcus lactis subsp. cremoris MG1363 4798930 YP_001031625.1 CDS llmg_0269 NC_009004.1 257718 259616 D Specificity unclear; ABC transporter ATP-binding and permease 257718..259616 Lactococcus lactis subsp. cremoris MG1363 4798618 YP_001031626.1 CDS llmg_0270 NC_009004.1 259707 260372 D hypothetical protein 259707..260372 Lactococcus lactis subsp. cremoris MG1363 4798504 YP_001031627.1 CDS llmg_0271 NC_009004.1 260420 261439 R Family membership; Gfo/Idh/MocA family oxidoreductase complement(260420..261439) Lactococcus lactis subsp. cremoris MG1363 4798503 YP_001031628.1 CDS llmg_0272 NC_009004.1 261423 261590 R hypothetical protein complement(261423..261590) Lactococcus lactis subsp. cremoris MG1363 4798279 YP_001031629.1 CDS luxS NC_009004.1 261789 262265 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(261789..262265) Lactococcus lactis subsp. cremoris MG1363 4798265 YP_001031630.1 CDS llmg_0274 NC_009004.1 262484 262717 D SSF55136: Bacterial regulatory factor, effector; Family membership; hypothetical protein 262484..262717 Lactococcus lactis subsp. cremoris MG1363 4797657 YP_001031631.1 CDS llmg_0275 NC_009004.1 262808 262948 D hypothetical protein 262808..262948 Lactococcus lactis subsp. cremoris MG1363 4797242 YP_001031632.1 CDS llmg_0276 NC_009004.1 263015 263860 D Family membership; aldo/keto reductase 263015..263860 Lactococcus lactis subsp. cremoris MG1363 4797232 YP_001031633.1 CDS llmg_0277 NC_009004.1 264100 264612 D Family membership; amidase 264100..264612 Lactococcus lactis subsp. cremoris MG1363 4797223 YP_001031634.1 CDS llmg_0278 NC_009004.1 264727 265275 D hypothetical protein 264727..265275 Lactococcus lactis subsp. cremoris MG1363 4797210 YP_001031635.1 CDS llmg_0279 NC_009004.1 265272 265556 D hypothetical protein 265272..265556 Lactococcus lactis subsp. cremoris MG1363 4797207 YP_001031636.1 CDS acmA NC_009004.1 265605 266918 R High confidence in function and specificity; N-acetylglucosaminidase complement(265605..266918) Lactococcus lactis subsp. cremoris MG1363 4797197 YP_001031637.1 CDS llmg_0281 NC_009004.1 267262 269505 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 267262..269505 Lactococcus lactis subsp. cremoris MG1363 4798795 YP_001031638.1 CDS nrdG NC_009004.1 269508 270107 D High confidence in function and specificity; anaerobic ribonucleoside-triphosphate reductase activating protein 269508..270107 Lactococcus lactis subsp. cremoris MG1363 4798410 YP_001031639.1 CDS llmg_0283 NC_009004.1 270179 270688 R hypothetical protein complement(270179..270688) Lactococcus lactis subsp. cremoris MG1363 4796572 YP_001031640.1 CDS llmg_0284 NC_009004.1 270892 272277 D hypothetical protein 270892..272277 Lactococcus lactis subsp. cremoris MG1363 4797547 YP_001031641.1 CDS llmg_0286 NC_009004.1 273847 275316 R contains WD40 repeat domain; hypothetical protein complement(273847..275316) Lactococcus lactis subsp. cremoris MG1363 4796625 YP_001031642.1 CDS cbiO NC_009004.1 276119 276952 D with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 276119..276952 Lactococcus lactis subsp. cremoris MG1363 4798204 YP_001031643.1 CDS cbiO NC_009004.1 277084 277950 D with CbiNQ forms the ABC transporter for cobalt import; Lactococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 277084..277950 Lactococcus lactis subsp. cremoris MG1363 4797678 YP_001031644.1 CDS cbiQ2 NC_009004.1 277950 278750 D High confidence in function and specificity; cobalt ABC transporter permease 277950..278750 Lactococcus lactis subsp. cremoris MG1363 4797660 YP_001031645.1 CDS llmg_0290 NC_009004.1 278772 279383 D hypothetical protein 278772..279383 Lactococcus lactis subsp. cremoris MG1363 4796814 YP_001031646.1 CDS dapD NC_009004.1 279596 280366 D High confidence in function and specificity; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 279596..280366 Lactococcus lactis subsp. cremoris MG1363 4798118 YP_001031647.1 CDS hipO1 NC_009004.1 280504 281634 D High confidence in function and specificity; hippurate hydrolase 280504..281634 Lactococcus lactis subsp. cremoris MG1363 4798877 YP_001031648.1 CDS xynD NC_009004.1 281791 282912 D High confidence in function and specificity; endo-1,4-beta-xylanase D 281791..282912 Lactococcus lactis subsp. cremoris MG1363 4797603 YP_001031649.1 CDS llmg_0294 NC_009004.1 283549 283656 D hypothetical protein 283549..283656 Lactococcus lactis subsp. cremoris MG1363 4796995 YP_001031650.1 CDS llmg_0295 NC_009004.1 283783 285207 D hypothetical protein 283783..285207 Lactococcus lactis subsp. cremoris MG1363 4798629 YP_001031651.1 CDS rpsD NC_009004.1 285418 286029 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 285418..286029 Lactococcus lactis subsp. cremoris MG1363 4798643 YP_001031652.1 CDS tex NC_009004.1 286157 288298 D contains S1 RNA binding domain; High confidence in function and specificity; transcription accessory protein TEX 286157..288298 Lactococcus lactis subsp. cremoris MG1363 4799021 YP_001031653.1 CDS llmg_0298 NC_009004.1 288431 288874 D metallopeptidase (SprT family); Family membership; hypothetical protein 288431..288874 Lactococcus lactis subsp. cremoris MG1363 4796932 YP_001031654.1 CDS add NC_009004.1 289175 290209 D catalyzes the formation of inosine from adenosine; adenosine deaminase 289175..290209 Lactococcus lactis subsp. cremoris MG1363 4798649 YP_001031655.1 CDS llmg_0300 NC_009004.1 290224 290661 R hypothetical protein complement(290224..290661) Lactococcus lactis subsp. cremoris MG1363 4796670 YP_001031656.1 CDS llmg_0301 NC_009004.1 290697 291065 R Family membership; MerR family transcriptional regulator complement(290697..291065) Lactococcus lactis subsp. cremoris MG1363 4798626 YP_001031657.1 CDS llmg_0302 NC_009004.1 291217 292902 R Conserved hypothetical protein MG423; Family membership; Zn-dependent hydrolase complement(291217..292902) Lactococcus lactis subsp. cremoris MG1363 4797784 YP_001031658.1 CDS llmg_0304 NC_009004.1 293096 293326 R Protein of unknown function DUF1447; hypothetical protein complement(293096..293326) Lactococcus lactis subsp. cremoris MG1363 4798348 YP_001031659.1 CDS llmg_0305 NC_009004.1 293431 293568 D hypothetical protein 293431..293568 Lactococcus lactis subsp. cremoris MG1363 4797209 YP_001031660.1 CDS llmg_0306 NC_009004.1 293664 294389 D Family membership; O-sialoglycoprotein endopeptidase 293664..294389 Lactococcus lactis subsp. cremoris MG1363 4797241 YP_001031661.1 CDS llmg_0307 NC_009004.1 294343 294912 D Region start changed from 294277 to 294343 (-66 bases); ribosomal-protein-alanine N-acetyltransferase 294343..294912 Lactococcus lactis subsp. cremoris MG1363 4798280 YP_001031662.1 CDS rimI2 NC_009004.1 294909 295379 D High confidence in function and specificity; ribosomal-protein-alanine acetyltransferase 294909..295379 Lactococcus lactis subsp. cremoris MG1363 4797231 YP_001031663.1 CDS gcp NC_009004.1 295382 296407 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 295382..296407 Lactococcus lactis subsp. cremoris MG1363 4798498 YP_001031664.1 CDS llmg_0310 NC_009004.1 296422 296622 D hypothetical protein 296422..296622 Lactococcus lactis subsp. cremoris MG1363 4796606 YP_001031665.1 CDS llmg_0311 NC_009004.1 296970 297761 R hypothetical protein complement(296970..297761) Lactococcus lactis subsp. cremoris MG1363 4796831 YP_001031666.1 CDS phnD NC_009004.1 298060 299109 D phosphonate ABC transporter phosphonate-binding protein phnD 298060..299109 Lactococcus lactis subsp. cremoris MG1363 4797365 YP_001031667.1 CDS phnC NC_009004.1 299225 299965 D High confidence in function and specificity; phosphonates import ATP-binding protein phnC 299225..299965 Lactococcus lactis subsp. cremoris MG1363 4799105 YP_001031668.1 CDS phnB NC_009004.1 299966 300778 D High confidence in function and specificity; phosphonate transport system permease phnB 299966..300778 Lactococcus lactis subsp. cremoris MG1363 4798213 YP_001031669.1 CDS llmg_0315 NC_009004.1 300798 301607 D Region start changed from 300786 to 300798 (-12 bases); phosphonate ABC transporter permease 300798..301607 Lactococcus lactis subsp. cremoris MG1363 4796676 YP_001031670.1 CDS cpdC NC_009004.1 301611 303173 D High confidence in function and specificity; 2,3-cyclic-nucleotide 2'phosphodiesterase 301611..303173 Lactococcus lactis subsp. cremoris MG1363 4798449 YP_001031671.1 CDS llmg_0317 NC_009004.1 303317 303436 D hypothetical protein 303317..303436 Lactococcus lactis subsp. cremoris MG1363 4798812 YP_001031672.1 CDS tpx NC_009004.1 303499 303981 D High confidence in function and specificity; thiol peroxidase 303499..303981 Lactococcus lactis subsp. cremoris MG1363 4797598 YP_001031673.1 CDS pepN NC_009004.1 304150 306690 D High confidence in function and specificity; PepN protein 304150..306690 Lactococcus lactis subsp. cremoris MG1363 4797345 YP_001031674.1 CDS napC NC_009004.1 306738 307928 R tetracycline resistance protein; High confidence in function and specificity; multidrug-efflux transporter protein complement(306738..307928) Lactococcus lactis subsp. cremoris MG1363 4798141 YP_001031675.1 CDS napB NC_009004.1 308410 308883 R High confidence in function and specificity; MarR family transcriptional regulator complement(308410..308883) Lactococcus lactis subsp. cremoris MG1363 4798013 YP_001031676.1 CDS llmg_0322 NC_009004.1 308880 310163 R CDF: cation diffusion facilitator family transporter; Family membership; cation transporter complement(308880..310163) Lactococcus lactis subsp. cremoris MG1363 4797817 YP_001031677.1 CDS llmg_0323 NC_009004.1 310439 310789 D PF03551.4: Transcriptional regulator PadR-like family; Function unclear; PadR-like family transcriptional regulator 310439..310789 Lactococcus lactis subsp. cremoris MG1363 4797596 YP_001031678.1 CDS lmrC NC_009004.1 311092 312831 D ABC transporter ATP binding and permease; High confidence in function and specificity; multidrug resistance protein C 311092..312831 Lactococcus lactis subsp. cremoris MG1363 4798592 YP_001031679.1 CDS lmrD NC_009004.1 312835 314829 D ABC transporter ATP-binding/membrane spanning protein; High confidence in function and specificity; multidrug resistance protein D 312835..314829 Lactococcus lactis subsp. cremoris MG1363 4796616 YP_001031680.1 CDS murA1 NC_009004.1 315003 316265 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 315003..316265 Lactococcus lactis subsp. cremoris MG1363 4797703 YP_001031681.1 CDS llmg_0327 NC_009004.1 316311 316529 D hypothetical protein 316311..316529 Lactococcus lactis subsp. cremoris MG1363 4798325 YP_001031682.1 CDS llmg_0328 NC_009004.1 316793 317443 D hypothetical protein 316793..317443 Lactococcus lactis subsp. cremoris MG1363 4798769 YP_001031683.1 CDS llmg_0329 NC_009004.1 317445 319160 D Family membership; ABC transporter ATP binding and permease 317445..319160 Lactococcus lactis subsp. cremoris MG1363 4797600 YP_001031684.1 CDS llmg_0330 NC_009004.1 319313 320194 D Major facilitator superfamily; Family membership; permease 319313..320194 Lactococcus lactis subsp. cremoris MG1363 4797548 YP_001031685.1 CDS llmg_0331 NC_009004.1 320425 320781 R Conserved hypothetical protein; hypothetical protein complement(320425..320781) Lactococcus lactis subsp. cremoris MG1363 4798335 YP_001031686.1 CDS llmg_0332 NC_009004.1 320805 321353 R BioY family; Specificity unclear; hypothetical protein complement(320805..321353) Lactococcus lactis subsp. cremoris MG1363 4796802 YP_001031687.1 CDS llmg_0333 NC_009004.1 321464 321940 R YbaK/prolyl-tRNA synthetase associated region, PF04073.3: YbaK_EbsC: ybaK/ebsC protein; hypothetical protein complement(321464..321940) Lactococcus lactis subsp. cremoris MG1363 4797580 YP_001031688.1 CDS llmg_0334 NC_009004.1 322003 322551 R Conserved hypothetical protein; hypothetical protein complement(322003..322551) Lactococcus lactis subsp. cremoris MG1363 4796873 YP_001031689.1 CDS plpA NC_009004.1 323286 324146 D High confidence in function and specificity; D-methionine-binding lipoprotein plpA precursor 323286..324146 Lactococcus lactis subsp. cremoris MG1363 4796804 YP_001031690.1 CDS plpB NC_009004.1 324291 325151 D High confidence in function and specificity; D-methionine-binding lipoprotein plpB precursor 324291..325151 Lactococcus lactis subsp. cremoris MG1363 4796731 YP_001031691.1 CDS plpC NC_009004.1 325297 326160 D High confidence in function and specificity; D-methionine-binding lipoprotein plpC precursor 325297..326160 Lactococcus lactis subsp. cremoris MG1363 4796583 YP_001031692.1 CDS dar NC_009004.1 326229 326999 D High confidence in function and specificity; acetoin(diacetyl)reductase 326229..326999 Lactococcus lactis subsp. cremoris MG1363 4798623 YP_001031693.1 CDS plpD NC_009004.1 327015 327875 D High confidence in function and specificity; D-methionine-binding lipoprotein plpD precursor 327015..327875 Lactococcus lactis subsp. cremoris MG1363 4798880 YP_001031694.1 CDS llmg_0341 NC_009004.1 327999 329105 D High confidence in function and specificity; amino acid ABC transporter ATP binding protein 327999..329105 Lactococcus lactis subsp. cremoris MG1363 4796615 YP_001031695.1 CDS llmg_0342 NC_009004.1 329105 329800 D Specificity unclear; amino acid ABC transporter permease 329105..329800 Lactococcus lactis subsp. cremoris MG1363 4797186 YP_001031696.1 CDS llmg_0343 NC_009004.1 329843 330391 D Protein of unknown function DUF1393; Conserved hypothetical protein; hypothetical protein 329843..330391 Lactococcus lactis subsp. cremoris MG1363 4799031 YP_001031697.1 CDS cbiO NC_009004.1 330510 332207 D High confidence in function and specificity; cobalt ABC transporter ATP-binding protein 330510..332207 Lactococcus lactis subsp. cremoris MG1363 4798558 YP_001031698.1 CDS cbiQ NC_009004.1 332200 333021 D High confidence in function and specificity; cobalt ABC transporter permease 332200..333021 Lactococcus lactis subsp. cremoris MG1363 4797658 YP_001031699.1 CDS fhuC NC_009004.1 333550 334329 D High confidence in function and specificity; ferrichrome ABC transporter fhuC 333550..334329 Lactococcus lactis subsp. cremoris MG1363 4799135 YP_001031700.1 CDS fhuB NC_009004.1 334322 335272 D High confidence in function and specificity; ferrichrome ABC transporter permease 334322..335272 Lactococcus lactis subsp. cremoris MG1363 4797020 YP_001031701.1 CDS fhuG NC_009004.1 335273 336211 D High confidence in function and specificity; ferrichrome ABC transporter permease 335273..336211 Lactococcus lactis subsp. cremoris MG1363 4797044 YP_001031702.1 CDS fhuD NC_009004.1 336295 337236 D High confidence in function and specificity; ferrichrome ABC transporter substrate-binding protein 336295..337236 Lactococcus lactis subsp. cremoris MG1363 4797014 YP_001031703.1 CDS fhuR NC_009004.1 337298 338203 D Also known as transcriptional activator of metCcysK operon cmbR; High confidence in function and specificity; HTH-type transcriptional regulator fhuR 337298..338203 Lactococcus lactis subsp. cremoris MG1363 4797038 YP_001031704.1 CDS araJ NC_009004.1 338265 339440 R Major facilitator superfamily; Family membership; arabinose efflux permease complement(338265..339440) Lactococcus lactis subsp. cremoris MG1363 4796972 YP_001031705.1 CDS llmg_0352 NC_009004.1 339453 340271 R Aldo/keto reductase; Family membership; aldo/keto reductase complement(339453..340271) Lactococcus lactis subsp. cremoris MG1363 4798241 YP_001031706.1 CDS llmg_0353 NC_009004.1 340413 340760 D Protein of unknown function DUF24; Conserved hypothetical protein; transcriptional regulator 340413..340760 Lactococcus lactis subsp. cremoris MG1363 4796636 YP_001031707.1 CDS llmg_0354 NC_009004.1 340804 341196 D Glyoxalase/extradiol ring-cleavage dioxygenase; Family membership; glyoxylase 340804..341196 Lactococcus lactis subsp. cremoris MG1363 4796979 YP_001031708.1 CDS gpmA NC_009004.1 341375 342076 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 341375..342076 Lactococcus lactis subsp. cremoris MG1363 4797419 YP_001031709.1 CDS ahpC NC_009004.1 342254 342817 D High confidence in function and specificity; alkyl hydroperoxide reductase 342254..342817 Lactococcus lactis subsp. cremoris MG1363 4796669 YP_001031710.1 CDS ahpF NC_009004.1 342883 344409 D High confidence in function and specificity; alkyl hydroperoxide reductase 342883..344409 Lactococcus lactis subsp. cremoris MG1363 4796588 YP_001031711.1 CDS pbp2B NC_009004.1 344604 346769 D High confidence in function and specificity; penicillin-binding protein 2B 344604..346769 Lactococcus lactis subsp. cremoris MG1363 4797509 YP_001031712.1 CDS recR NC_009004.1 346899 347495 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 346899..347495 Lactococcus lactis subsp. cremoris MG1363 4798152 YP_001031713.1 CDS ddl NC_009004.1 347614 348663 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 347614..348663 Lactococcus lactis subsp. cremoris MG1363 4798238 YP_001031714.1 CDS murF NC_009004.1 348927 350249 D D-Ala-D-Ala adding enzym; High confidence in function and specificity; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 348927..350249 Lactococcus lactis subsp. cremoris MG1363 4797461 YP_001031715.1 CDS dppA NC_009004.1 350418 352070 D Conserved hypothetical protein; dipeptide-binding protein precursor 350418..352070 Lactococcus lactis subsp. cremoris MG1363 4796664 YP_001031716.1 CDS dppB NC_009004.1 354096 355007 D Conserved hypothetical protein; dipeptide transport system permease dppB 354096..355007 Lactococcus lactis subsp. cremoris MG1363 4798399 YP_001031717.1 CDS dppC NC_009004.1 355023 356054 D High confidence in function and specificity; dipeptide transport system permease dppC 355023..356054 Lactococcus lactis subsp. cremoris MG1363 4796784 YP_001031718.1 CDS dppD NC_009004.1 356057 357106 D High confidence in function and specificity; dipeptide transport ATP-binding protein dppD 356057..357106 Lactococcus lactis subsp. cremoris MG1363 4798365 YP_001031719.1 CDS dppF NC_009004.1 357106 358044 D High confidence in function and specificity; dipeptide transport ATP-binding protein dppF 357106..358044 Lactococcus lactis subsp. cremoris MG1363 4798379 YP_001031720.1 CDS prfC NC_009004.1 358445 360016 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 358445..360016 Lactococcus lactis subsp. cremoris MG1363 4798388 YP_001031721.1 CDS rheA NC_009004.1 360338 361993 D Similar to cold-shock DEAD-box protein A (ATP- dependent RNA helicase deaD); High confidence in function and specificity; ATP-dependent RNA helicase 360338..361993 Lactococcus lactis subsp. cremoris MG1363 4797126 YP_001031722.1 CDS llmg_0370 NC_009004.1 362113 362202 R hypothetical protein complement(362113..362202) Lactococcus lactis subsp. cremoris MG1363 4796900 YP_001031723.1 CDS era NC_009004.1 362691 363602 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 362691..363602 Lactococcus lactis subsp. cremoris MG1363 4797610 YP_001031724.1 CDS asnB NC_009004.1 363700 365292 D functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 363700..365292 Lactococcus lactis subsp. cremoris MG1363 4798548 YP_001031725.1 CDS fpg NC_009004.1 365484 366302 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 365484..366302 Lactococcus lactis subsp. cremoris MG1363 4797219 YP_001031726.1 CDS recA NC_009004.1 366455 367618 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 366455..367618 Lactococcus lactis subsp. cremoris MG1363 4797934 YP_001031727.1 CDS llmg_0375 NC_009004.1 367634 369016 R Specificity unclear; amino acid permease complement(367634..369016) Lactococcus lactis subsp. cremoris MG1363 4796718 YP_001031728.1 CDS llmg_0376 NC_009004.1 369088 370467 R Specificity unclear; amino acid permease complement(369088..370467) Lactococcus lactis subsp. cremoris MG1363 4796620 YP_001031729.1 CDS llmg_0377 NC_009004.1 370614 370994 D Protein of unknown function DUF1333; hypothetical protein 370614..370994 Lactococcus lactis subsp. cremoris MG1363 4796753 YP_001031730.1 CDS llmg_0378 NC_009004.1 370969 371292 D hypothetical protein 370969..371292 Lactococcus lactis subsp. cremoris MG1363 4798262 YP_001031731.1 CDS llmg_0379 NC_009004.1 371516 372034 D hypothetical protein 371516..372034 Lactococcus lactis subsp. cremoris MG1363 4798890 YP_001031732.1 CDS llmg_0380 NC_009004.1 372098 372691 R contains CYTH domain., Similar to adenylate cyclases; hypothetical protein complement(372098..372691) Lactococcus lactis subsp. cremoris MG1363 4798921 YP_001031733.1 CDS llmg_0381 NC_009004.1 372911 373717 D Protein of unknown function DUF817; Conserved hypothetical protein; hypothetical protein 372911..373717 Lactococcus lactis subsp. cremoris MG1363 4797115 YP_001031734.1 CDS llmg_0382 NC_009004.1 373905 374564 D Contains region found in RelA / SpoT proteins; Specificity unclear; GTP pyrophosphokinase 373905..374564 Lactococcus lactis subsp. cremoris MG1363 4797902 YP_001031735.1 CDS ppnK NC_009004.1 374551 375363 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 374551..375363 Lactococcus lactis subsp. cremoris MG1363 4797928 YP_001031736.1 CDS rluE NC_009004.1 375363 376244 D High confidence in function and specificity; ribosomal large subunit pseudouridine synthase 375363..376244 Lactococcus lactis subsp. cremoris MG1363 4798239 YP_001031737.1 CDS ppiA NC_009004.1 376287 377120 R High confidence in function and specificity; cyclophilin type peptidyl-prolyl cis-trans isomerase complement(376287..377120) Lactococcus lactis subsp. cremoris MG1363 4797555 YP_001031738.1 CDS lysQ NC_009004.1 377428 378861 D Lysine specific permease; High confidence in function and specificity; amino-acid permease lysQ 377428..378861 Lactococcus lactis subsp. cremoris MG1363 4797084 YP_001031739.1 CDS llmg_0387 NC_009004.1 379021 379824 D Similar to NADPH-dependent FMN reductases; Family membership; hypothetical protein 379021..379824 Lactococcus lactis subsp. cremoris MG1363 4797153 YP_001031740.1 CDS apbE NC_009004.1 379821 380798 D ApbE-like lipoprotein; High confidence in function and specificity; thiamine biosynthesis lipoprotein apbE precursor 379821..380798 Lactococcus lactis subsp. cremoris MG1363 4797950 YP_001031741.1 CDS lysS NC_009004.1 380881 382365 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(380881..382365) Lactococcus lactis subsp. cremoris MG1363 4799123 YP_001031742.1 CDS rlrG NC_009004.1 382562 383380 R High confidence in function and specificity; LysR family transcriptional regulator complement(382562..383380) Lactococcus lactis subsp. cremoris MG1363 4798512 YP_001031743.1 CDS llmg_0391 NC_009004.1 383544 384539 D Region start changed from 383499 to 383544 (-45 bases); hypothetical protein 383544..384539 Lactococcus lactis subsp. cremoris MG1363 4798662 YP_001031744.1 CDS ldhB NC_009004.1 384757 385701 R High confidence in function and specificity; L-lactate dehydrogenase complement(384757..385701) Lactococcus lactis subsp. cremoris MG1363 4797254 YP_001031745.1 CDS rlrD NC_009004.1 386016 386837 R High confidence in function and specificity; LysR family transcriptional regulator complement(386016..386837) Lactococcus lactis subsp. cremoris MG1363 4796655 YP_001031746.1 CDS llmg_0394 NC_009004.1 386993 387967 D PF03595.4: C4-dicarboxylate transporter/malic acid transport protein; Family membership; permease 386993..387967 Lactococcus lactis subsp. cremoris MG1363 4797112 YP_001031747.1 CDS thiI NC_009004.1 388323 389543 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 388323..389543 Lactococcus lactis subsp. cremoris MG1363 4797328 YP_001031748.1 CDS llmg_0397 NC_009004.1 391309 391914 D High confidence in function and specificity; NAD(P)H dehydrogenase (quinone) 391309..391914 Lactococcus lactis subsp. cremoris MG1363 4797329 YP_001031749.1 CDS llmg_0398 NC_009004.1 392012 392446 D PF02566.5: OsmC-like protein; hypothetical protein 392012..392446 Lactococcus lactis subsp. cremoris MG1363 4797881 YP_001031750.1 CDS nha NC_009004.1 392501 394543 R High confidence in function and specificity; Na+/H+ antiporter complement(392501..394543) Lactococcus lactis subsp. cremoris MG1363 4797175 YP_001031751.1 CDS llmg_0400 NC_009004.1 394634 395104 R hypothetical protein complement(394634..395104) Lactococcus lactis subsp. cremoris MG1363 4797298 YP_001031752.1 CDS tyrS NC_009004.1 395229 396488 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(395229..396488) Lactococcus lactis subsp. cremoris MG1363 4797177 YP_001031753.1 CDS pbp1B NC_009004.1 396633 399071 D High confidence in function and specificity; penicillin-binding protein 1B 396633..399071 Lactococcus lactis subsp. cremoris MG1363 4797912 YP_001031754.1 CDS pepA NC_009004.1 399112 400179 R High confidence in function and specificity; glutamyl-aminopeptidase complement(399112..400179) Lactococcus lactis subsp. cremoris MG1363 4796852 YP_001031755.1 CDS llmg_0405 NC_009004.1 400282 400566 D hypothetical protein 400282..400566 Lactococcus lactis subsp. cremoris MG1363 4798476 YP_001031756.1 CDS trxH NC_009004.1 400611 400928 D Thioredoxin domain 2; Conserved hypothetical protein; thioredoxin H-type 400611..400928 Lactococcus lactis subsp. cremoris MG1363 4797185 YP_001031757.1 CDS pheT NC_009004.1 401034 401660 D t-RNA-binding region; High confidence in function and specificity; phenylalanyl-tRNA synthetase beta chain 401034..401660 Lactococcus lactis subsp. cremoris MG1363 4797346 YP_001031758.1 CDS noxE NC_009004.1 401822 403162 D FAD-dependent pyridine nucleotide-disulphide oxidoreductase, Pyridine nucleotide-disulphide oxidoreductase; High confidence in function and specificity; NADH oxidase 401822..403162 Lactococcus lactis subsp. cremoris MG1363 4796799 YP_001031759.1 CDS ssbA NC_009004.1 403253 403642 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 403253..403642 Lactococcus lactis subsp. cremoris MG1363 4798222 YP_001031760.1 CDS groES NC_009004.1 403761 404045 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 403761..404045 Lactococcus lactis subsp. cremoris MG1363 4798582 YP_001031761.1 CDS groEL NC_009004.1 404132 405760 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 404132..405760 Lactococcus lactis subsp. cremoris MG1363 4798738 YP_001031762.1 CDS vicX NC_009004.1 405810 406622 R Ribonuclease Z (tRNA 3 endonuclease)., Beta- lactamase-like, Metallo-beta-lactamase superfamily; High confidence in function and specificity; ribonuclease Z complement(405810..406622) Lactococcus lactis subsp. cremoris MG1363 4798732 YP_001031763.1 CDS kinC NC_009004.1 406813 408240 R Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, cztS_silS_copS: heavy metal sensor kinase; High confidence in function and specificity; sensor histidine kinase complement(406813..408240) Lactococcus lactis subsp. cremoris MG1363 4798420 YP_001031764.1 CDS llrC NC_009004.1 408233 408934 R Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein; two-component system regulator complement(408233..408934) Lactococcus lactis subsp. cremoris MG1363 4797664 YP_001031765.1 CDS tmk NC_009004.1 409112 409747 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 409112..409747 Lactococcus lactis subsp. cremoris MG1363 4796610 YP_001031766.1 CDS holB NC_009004.1 409880 410740 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 409880..410740 Lactococcus lactis subsp. cremoris MG1363 4797098 YP_001031767.1 CDS llmg_0417 NC_009004.1 410790 411572 D PSP1 C-terminal conserved region; High confidence in function and specificity; hypothetical protein 410790..411572 Lactococcus lactis subsp. cremoris MG1363 4796639 YP_001031768.1 CDS llmg_0418 NC_009004.1 411565 411891 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 411565..411891 Lactococcus lactis subsp. cremoris MG1363 4797297 YP_001031769.1 CDS llmg_0419 NC_009004.1 411891 412766 D Tetrapyrrole (Corrin/Porphyrin) Methylases; hypothetical protein 411891..412766 Lactococcus lactis subsp. cremoris MG1363 4798008 YP_001031770.1 CDS llmg_0420 NC_009004.1 412844 413035 R hypothetical protein complement(412844..413035) Lactococcus lactis subsp. cremoris MG1363 4797267 YP_001031771.1 CDS drrB NC_009004.1 413110 413922 R Belongs to the ABC-2 integral membrane protein family; Conserved hypothetical protein; daunorubicin resistance transmembrane protein complement(413110..413922) Lactococcus lactis subsp. cremoris MG1363 4797967 YP_001031772.1 CDS llmg_0422 NC_009004.1 413935 414072 R hypothetical protein complement(413935..414072) Lactococcus lactis subsp. cremoris MG1363 4798376 YP_001031773.1 CDS drrA NC_009004.1 414082 414864 R High confidence in function and specificity; daunorubicin resistance ABC transporter ATP-binding subunit complement(414082..414864) Lactococcus lactis subsp. cremoris MG1363 4797810 YP_001031774.1 CDS llmg_0424 NC_009004.1 414996 415496 D Transcriptional regulator , Cytolysin slyA, InterPro: Bacterial regulatory protein, MarR; High confidence in function and specificity; transcriptional regulator 414996..415496 Lactococcus lactis subsp. cremoris MG1363 4798362 YP_001031775.1 CDS mvk NC_009004.1 415627 416559 R Mevalonate kinase, GHMP kinases ATP- binding protein, mevalon_kin: mevalonate kinase; High confidence in function and specificity; mevalonate kinase complement(415627..416559) Lactococcus lactis subsp. cremoris MG1363 4798261 YP_001031776.1 CDS mvaD NC_009004.1 416868 417824 D Diphosphomevalonate decarboxylase, GHMP kinases ATP-binding protein, mevDPdecarb: diphosphomevalonate decarboxylase; High confidence in function and specificity; diphosphomevalonate decarboxylase 416868..417824 Lactococcus lactis subsp. cremoris MG1363 4796736 YP_001031777.1 CDS llmg_0427 NC_009004.1 417811 418800 D GHMP kinases ATP-binding protein; High confidence in function and specificity; phosphomevalonate kinase 417811..418800 Lactococcus lactis subsp. cremoris MG1363 4798562 YP_001031778.1 CDS fni NC_009004.1 418923 419972 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 418923..419972 Lactococcus lactis subsp. cremoris MG1363 4798189 YP_001031779.1 CDS sodA NC_009004.1 420126 420746 D Manganese and iron superoxide dismutase, Iron/manganese superoxide dismutases, C-terminal domain; High confidence in function and specificity; SodA protein 420126..420746 Lactococcus lactis subsp. cremoris MG1363 4796682 YP_001031780.1 CDS cstA NC_009004.1 420997 423351 D Carbon starvation protein CstA; Conserved hypothetical protein; carbon starvation protein A 420997..423351 Lactococcus lactis subsp. cremoris MG1363 4798951 YP_001031781.1 CDS llmg_0431 NC_009004.1 423532 424191 R Region start changed from 424275 to 424191 (-84 bases); acyl carrier protein phosphodiesterase 2 complement(423532..424191) Lactococcus lactis subsp. cremoris MG1363 4798838 YP_001031782.1 CDS llmg_0432 NC_009004.1 424278 425216 D transcriptional regulator 424278..425216 Lactococcus lactis subsp. cremoris MG1363 4797094 YP_001031783.1 CDS rheB NC_009004.1 425365 426705 D DEAD/DEAH box helicase; ATP-dependent RNA helicase 425365..426705 Lactococcus lactis subsp. cremoris MG1363 4798242 YP_001031784.1 CDS llmg_0434 NC_009004.1 426709 427293 D Conserved hypothetical protein; hypothetical protein 426709..427293 Lactococcus lactis subsp. cremoris MG1363 4798201 YP_001031785.1 CDS hexR NC_009004.1 427409 428155 D Contains 1 HTH rpiR-type DNA-binding domain; Conserved hypothetical protein; HTH-type transcriptional regulator 427409..428155 Lactococcus lactis subsp. cremoris MG1363 4798495 YP_001031786.1 CDS llmg_0436 NC_009004.1 428133 428228 D hypothetical protein 428133..428228 Lactococcus lactis subsp. cremoris MG1363 4797585 YP_001031787.1 CDS ptcB NC_009004.1 428397 428723 D Lichenan- permease IIB component, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, PTS system, Lactose/Cellobiose specific IIB subunit; High confidence in function and specificity; cellobiose-specific PTS system IIB component 428397..428723 Lactococcus lactis subsp. cremoris MG1363 4797109 YP_001031788.1 CDS ptcA NC_009004.1 428806 429156 D PTS system, lactose-specific IIA component , Lactose- permease IIA component, Phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit, PTS system, Lactose/Cellobiose specific IIA subunit; High confidence in function and specificity; cellobiose-specific PTS system IIA component 428806..429156 Lactococcus lactis subsp. cremoris MG1363 4798642 YP_001031789.1 CDS llmg_0439 NC_009004.1 429250 429978 D Family membership; LacI family transcriptional regulator 429250..429978 Lactococcus lactis subsp. cremoris MG1363 4798730 YP_001031790.1 CDS ptcC NC_009004.1 430271 431608 D PTS system, lichenan-specific IIC component; High confidence in function and specificity; cellobiose-specific PTS system IIC component 430271..431608 Lactococcus lactis subsp. cremoris MG1363 4796893 YP_001031791.1 CDS celA NC_009004.1 431698 433134 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 431698..433134 Lactococcus lactis subsp. cremoris MG1363 4798119 YP_001031792.1 CDS llmg_0442 NC_009004.1 433420 433701 D hypothetical protein 433420..433701 Lactococcus lactis subsp. cremoris MG1363 4798650 YP_001031793.1 CDS llmg_0443 NC_009004.1 433884 434060 D hypothetical protein 433884..434060 Lactococcus lactis subsp. cremoris MG1363 4797471 YP_001031794.1 CDS ligA NC_009004.1 434066 436126 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 434066..436126 Lactococcus lactis subsp. cremoris MG1363 4798183 YP_001031795.2 CDS llmg_0445 NC_009004.1 436267 437298 D similar to YegS from E. coli; lipid kinase 436267..437298 Lactococcus lactis subsp. cremoris MG1363 4796597 YP_001031796.1 CDS msmK NC_009004.1 437518 438654 D Probable multiple sugar-binding transport ATP- binding protein; Conserved hypothetical protein; multiple sugar-binding transport ATP-binding protein 437518..438654 Lactococcus lactis subsp. cremoris MG1363 4797024 YP_001031797.1 CDS nifJ NC_009004.1 438961 442632 D Pyruvate:ferredoxin (flavodoxin) oxidoreductase, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; High confidence in function and specificity; NifJ protein 438961..442632 Lactococcus lactis subsp. cremoris MG1363 4797183 YP_001031798.1 CDS llmg_0448 NC_009004.1 442807 443685 D hypothetical protein 442807..443685 Lactococcus lactis subsp. cremoris MG1363 4797258 YP_001031799.1 CDS llmg_0449 NC_009004.1 443675 443962 D hypothetical protein 443675..443962 Lactococcus lactis subsp. cremoris MG1363 4798231 YP_001031800.1 CDS llmg_0450 NC_009004.1 443980 444633 D hypothetical protein 443980..444633 Lactococcus lactis subsp. cremoris MG1363 4797071 YP_001031801.1 CDS glmM NC_009004.1 444678 446036 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 444678..446036 Lactococcus lactis subsp. cremoris MG1363 4798497 YP_001031802.1 CDS treR NC_009004.1 446110 446826 R GntR family transcriptional regulator; Conserved hypothetical protein; trehalose operon transcriptional repressor complement(446110..446826) Lactococcus lactis subsp. cremoris MG1363 4797118 YP_001031803.1 CDS llmg_0453 NC_009004.1 446937 447422 D PTS system likely trehalose specific; High confidence in function and specificity; sucrose-specific PTS enzyme IIABC 446937..447422 Lactococcus lactis subsp. cremoris MG1363 4797778 YP_001031804.1 CDS llmg_0454 NC_009004.1 447563 449128 D PTS-IIBC-Tre: PTS system, trehalose-specific IIBC component; High confidence in function and specificity; beta-glucoside-specific PTS system IIABC component 447563..449128 Lactococcus lactis subsp. cremoris MG1363 4797093 YP_001031805.1 CDS trePP NC_009004.1 449195 451504 D Glycoside transferase, six-hairpin, Glycosyl hydrolase 65 central catalytic domain; High confidence in function and specificity; trehalose/maltose hydrolase 449195..451504 Lactococcus lactis subsp. cremoris MG1363 4797140 YP_001031806.1 CDS pgmB NC_009004.1 451657 452322 D haloacid dehalogenase-like hydrolase, bPGM: beta- phosphoglucomutase; High confidence in function and specificity; beta-phosphoglucomutase 451657..452322 Lactococcus lactis subsp. cremoris MG1363 4797271 YP_001031807.1 CDS llmg_0457 NC_009004.1 452381 453148 R PS50187: Esterase/lipase/thioesterase; Family membership; lipase/esterase complement(452381..453148) Lactococcus lactis subsp. cremoris MG1363 4798403 YP_001031808.1 CDS llmg_0458 NC_009004.1 453258 453956 D High confidence in function and specificity; hypothetical protein 453258..453956 Lactococcus lactis subsp. cremoris MG1363 4797058 YP_001031809.1 CDS llmg_0459 NC_009004.1 454115 454561 D Uncharacterised P-loop hydrolase UPF0079; hypothetical protein 454115..454561 Lactococcus lactis subsp. cremoris MG1363 4797101 YP_001031810.1 CDS llmg_0460 NC_009004.1 454558 455076 D GCN5-related N-acetyltransferase, Acetyltransferase (GNAT) family; Conserved hypothetical protein; acetyltransferase 454558..455076 Lactococcus lactis subsp. cremoris MG1363 4796988 YP_001031811.1 CDS lytR NC_009004.1 455181 456560 D Cell envelope-related transcriptional attenuator domain, lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain; Conserved hypothetical protein; transcriptional regulator 455181..456560 Lactococcus lactis subsp. cremoris MG1363 4796877 YP_001031812.1 CDS truA NC_009004.1 456961 457722 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 456961..457722 Lactococcus lactis subsp. cremoris MG1363 4797597 YP_001031813.1 CDS thiD2 NC_009004.1 457756 458544 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 457756..458544 Lactococcus lactis subsp. cremoris MG1363 4798726 YP_001031814.1 CDS llmg_0464 NC_009004.1 458584 459084 D High confidence in function and specificity; hypothetical protein 458584..459084 Lactococcus lactis subsp. cremoris MG1363 4797018 YP_001031815.1 CDS llmg_0465 NC_009004.1 459065 459607 D hypothetical protein 459065..459607 Lactococcus lactis subsp. cremoris MG1363 4796885 YP_001031816.1 CDS aspC NC_009004.1 459608 460744 D Serine--pyruvate aminotransferase , (SPT) (Alanine-- glyoxylate aminotransferase)(AGT)., Aminotransferase, class V; High confidence in function and specificity; aminotransferase 459608..460744 Lactococcus lactis subsp. cremoris MG1363 4796851 YP_001031817.1 CDS pyrG NC_009004.1 461021 462628 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 461021..462628 Lactococcus lactis subsp. cremoris MG1363 4798405 YP_001031818.1 CDS llmg_0468 NC_009004.1 462840 463676 D hypothetical protein 462840..463676 Lactococcus lactis subsp. cremoris MG1363 4798463 YP_001031819.1 CDS llmg_0469 NC_009004.1 463673 464230 D hypothetical protein 463673..464230 Lactococcus lactis subsp. cremoris MG1363 4799128 YP_001031820.1 CDS llmg_0470 NC_009004.1 464462 465343 D domain: Collagen alpha 1(XVII); High confidence in function and specificity; hypothetical protein 464462..465343 Lactococcus lactis subsp. cremoris MG1363 4799131 YP_001031821.1 CDS llmg_0471 NC_009004.1 465350 465922 D hypothetical protein 465350..465922 Lactococcus lactis subsp. cremoris MG1363 4796593 YP_001031822.1 CDS llmg_0472 NC_009004.1 465930 466493 D hypothetical protein 465930..466493 Lactococcus lactis subsp. cremoris MG1363 4797494 YP_001031823.1 CDS llmg_0473 NC_009004.1 466853 467446 D hypothetical protein 466853..467446 Lactococcus lactis subsp. cremoris MG1363 4796641 YP_001031824.1 CDS llmg_0474 NC_009004.1 467450 467908 D hypothetical protein 467450..467908 Lactococcus lactis subsp. cremoris MG1363 4796570 YP_001031825.1 CDS llmg_0475 NC_009004.1 467926 468840 D Similar to ldhB; Specificity unclear; malate/lactate dehydrogenase 467926..468840 Lactococcus lactis subsp. cremoris MG1363 4797434 YP_001031826.1 CDS llmg_0476 NC_009004.1 468875 469747 R Protein of unknown function DUF1003; Conserved hypothetical protein; hypothetical protein complement(468875..469747) Lactococcus lactis subsp. cremoris MG1363 4796638 YP_001031827.1 CDS llmg_0477 NC_009004.1 470104 470304 R Conserved hypothetical protein; hypothetical protein complement(470104..470304) Lactococcus lactis subsp. cremoris MG1363 4796712 YP_001031828.1 CDS ntd NC_009004.1 470360 470872 R Family membership; nucleoside deoxyribosyltransferase complement(470360..470872) Lactococcus lactis subsp. cremoris MG1363 4797485 YP_001031829.1 CDS llmg_0479 NC_009004.1 470856 471410 R TIGR00730: conserved hypothetical protein; hypothetical protein complement(470856..471410) Lactococcus lactis subsp. cremoris MG1363 4797270 YP_001031830.1 CDS dukA NC_009004.1 471410 472063 R High confidence in function and specificity; deoxyguanosine kinase complement(471410..472063) Lactococcus lactis subsp. cremoris MG1363 4797488 YP_001031831.1 CDS llmg_0481 NC_009004.1 472626 473660 D PF03412.4: Peptidase C39, bacteriocin processing; hypothetical protein 472626..473660 Lactococcus lactis subsp. cremoris MG1363 4798944 YP_001031832.1 CDS llmg_0482 NC_009004.1 473713 474897 D hypothetical protein 473713..474897 Lactococcus lactis subsp. cremoris MG1363 4797412 YP_001031833.1 CDS dnaE NC_009004.1 475040 478252 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 475040..478252 Lactococcus lactis subsp. cremoris MG1363 4797492 YP_001031834.1 CDS llmg_0484 NC_009004.1 478340 479329 D Function unclear; LacI family transcriptional regulator 478340..479329 Lactococcus lactis subsp. cremoris MG1363 4798382 YP_001031835.1 CDS llmg_0485 NC_009004.1 479423 479818 D PF06271.1: RDD family protein, contains AL9 export element; Family membership; hypothetical protein 479423..479818 Lactococcus lactis subsp. cremoris MG1363 4796967 YP_001031836.1 CDS llmg_0486 NC_009004.1 479811 480086 D Conserved hypothetical protein; hypothetical protein 479811..480086 Lactococcus lactis subsp. cremoris MG1363 4799127 YP_001031837.1 CDS llmg_0487 NC_009004.1 480171 482471 D Glycoside transferase, six-hairpin, Glycosyl hydrolase 65 central catalytic domain; Specificity unclear; trehalose/maltose hydrolase 480171..482471 Lactococcus lactis subsp. cremoris MG1363 4797621 YP_001031838.1 CDS llmg_0488 NC_009004.1 482525 483790 D Specificity unclear; multiple sugar-binding protein 482525..483790 Lactococcus lactis subsp. cremoris MG1363 4796601 YP_001031839.1 CDS llmg_0489 NC_009004.1 483966 484841 D Specificity unclear; sugar transport system permease 483966..484841 Lactococcus lactis subsp. cremoris MG1363 4796717 YP_001031840.1 CDS llmg_0490 NC_009004.1 484822 485673 D Specificity unclear; sugar transport system permease 484822..485673 Lactococcus lactis subsp. cremoris MG1363 4796719 YP_001031841.1 CDS hly NC_009004.1 485703 486356 R High confidence in function and specificity; hemolysin like protein complement(485703..486356) Lactococcus lactis subsp. cremoris MG1363 4796613 YP_001031842.1 CDS llmg_0492 NC_009004.1 486558 487394 D PF02645.5: degV family protein; Family membership; hypothetical protein 486558..487394 Lactococcus lactis subsp. cremoris MG1363 4796596 YP_001031843.1 CDS llmg_0493 NC_009004.1 487449 488288 D PF00657.10: GDSL-like Lipase/Acylhydrolase; Family membership; esterase 487449..488288 Lactococcus lactis subsp. cremoris MG1363 4796768 YP_001031844.1 CDS nagZ NC_009004.1 488285 489505 D High confidence in function and specificity; beta-N-acetylglucosaminidase 488285..489505 Lactococcus lactis subsp. cremoris MG1363 4797619 YP_001031845.1 CDS llmg_0495 NC_009004.1 489514 490170 D hypothetical protein 489514..490170 Lactococcus lactis subsp. cremoris MG1363 4798657 YP_001031846.1 CDS hllA NC_009004.1 490275 490550 D Histone-like bacterial DNA-binding protein; High confidence in function and specificity; HU-like DNA-binding protein 490275..490550 Lactococcus lactis subsp. cremoris MG1363 4797353 YP_001031847.1 CDS llmg_0497 NC_009004.1 490661 491158 R GCN5-related N-acetyltransferase; Family membership; hypothetical protein complement(490661..491158) Lactococcus lactis subsp. cremoris MG1363 4796659 YP_001031848.1 CDS ogt NC_009004.1 491341 491850 D Methylated-DNA--protein-cysteine methyltransferase; High confidence in function and specificity; 6-O-methylguanine DNA methyltransferase 491341..491850 Lactococcus lactis subsp. cremoris MG1363 4799036 YP_001031849.1 CDS adaA NC_009004.1 491865 492413 D High confidence in function and specificity; methylphosphotriester-DNA alkyltransferase 491865..492413 Lactococcus lactis subsp. cremoris MG1363 4799094 YP_001031850.1 CDS nhoA NC_009004.1 492425 493228 D High confidence in function and specificity; arylamine N-acetyltransferase 2 492425..493228 Lactococcus lactis subsp. cremoris MG1363 4798917 YP_001031851.1 CDS llmg_0501 NC_009004.1 493375 494184 D Specificity unclear; ABC transporter ATP-binding protein 493375..494184 Lactococcus lactis subsp. cremoris MG1363 4798049 YP_001031852.1 CDS llmg_0502 NC_009004.1 494181 494906 D Specificity unclear; ABC transporter permease 494181..494906 Lactococcus lactis subsp. cremoris MG1363 4798190 YP_001031853.1 CDS llmg_0503 NC_009004.1 494968 495426 D PF04397.5: LytTr DNA-binding domain; Conserved hypothetical protein; LytR family transcriptional regulator 494968..495426 Lactococcus lactis subsp. cremoris MG1363 4798212 YP_001031854.1 CDS llmg_0504 NC_009004.1 495423 495800 D hypothetical protein 495423..495800 Lactococcus lactis subsp. cremoris MG1363 4797116 YP_001031855.1 CDS nifZ NC_009004.1 495909 497054 D Aminotransferase class-V; High confidence in function and specificity; pyridoxal-phosphate dependent aminotransferase 495909..497054 Lactococcus lactis subsp. cremoris MG1363 4797029 YP_001031856.1 CDS llmg_0506 NC_009004.1 497205 498083 D PF00877.9: NLP/P60 domain; Function unclear; hypothetical protein 497205..498083 Lactococcus lactis subsp. cremoris MG1363 4797885 YP_001031857.1 CDS llmg_0507 NC_009004.1 498140 499789 R Similar to oligopeptide ABC transporter substrate binding proteins; Conserved hypothetical protein; peptide binding protein complement(498140..499789) Lactococcus lactis subsp. cremoris MG1363 4796918 YP_001031858.1 CDS llmg_0508 NC_009004.1 499981 500913 R Region start changed from 500979 to 500913 (-66 bases); cysteine synthase complement(499981..500913) Lactococcus lactis subsp. cremoris MG1363 4797035 YP_001031859.1 CDS acmD NC_009004.1 501132 502217 D High confidence in function and specificity; N-acetylglucosaminidase 501132..502217 Lactococcus lactis subsp. cremoris MG1363 4796821 YP_001031860.1 CDS llmg_0510 NC_009004.1 502253 502885 R Metallo-beta-lactamase superfamily; Family membership; Zn-dependent hydrolase complement(502253..502885) Lactococcus lactis subsp. cremoris MG1363 4798885 YP_001031861.1 CDS ponA NC_009004.1 502886 504967 R penicillin-binding protein 1a complement(502886..504967) Lactococcus lactis subsp. cremoris MG1363 4797936 YP_001031862.1 CDS recU NC_009004.1 504954 505595 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(504954..505595) Lactococcus lactis subsp. cremoris MG1363 4796592 YP_001031863.1 CDS llmg_0513 NC_009004.1 505676 506200 D Protein of unknown function DUF1273; hypothetical protein 505676..506200 Lactococcus lactis subsp. cremoris MG1363 4797089 YP_001031864.1 CDS llmg_0514 NC_009004.1 506345 506746 D Similar to regulatory protein spx; hypothetical protein 506345..506746 Lactococcus lactis subsp. cremoris MG1363 4797165 YP_001031865.1 CDS llmg_0515 NC_009004.1 506967 507248 D Uncharacterised protein family (UPF0223); hypothetical protein 506967..507248 Lactococcus lactis subsp. cremoris MG1363 4797194 YP_001031866.1 CDS suhB NC_009004.1 507232 507993 D Inositol monophosphatase; High confidence in function and specificity; myo-inositol-1(or 4)-monophosphatase 507232..507993 Lactococcus lactis subsp. cremoris MG1363 4798314 YP_001031867.1 CDS murA2 NC_009004.1 508088 509368 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 508088..509368 Lactococcus lactis subsp. cremoris MG1363 4798608 YP_001031868.1 CDS llmg_0518 NC_009004.1 509368 509559 D hypothetical protein 509368..509559 Lactococcus lactis subsp. cremoris MG1363 4797477 YP_001031869.1 CDS tig NC_009004.1 509736 511019 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 509736..511019 Lactococcus lactis subsp. cremoris MG1363 4797884 YP_001031870.1 CDS dnaG NC_009004.1 517878 519791 D synthesizes RNA primers at the replication forks; DNA primase 517878..519791 Lactococcus lactis subsp. cremoris MG1363 4796955 YP_001031871.1 CDS rpoD NC_009004.1 519868 521211 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 519868..521211 Lactococcus lactis subsp. cremoris MG1363 4798386 YP_001031872.1 CDS llmg_0522 NC_009004.1 521309 522052 D contains sugar isomerase domain PF01380.10; Function unclear; transcriptional regulator 521309..522052 Lactococcus lactis subsp. cremoris MG1363 4796785 YP_001031873.1 CDS glpT NC_009004.1 522209 523588 D Major Facilitator Superfamily; High confidence in function and specificity; glycerol-3-phosphatase transporter 522209..523588 Lactococcus lactis subsp. cremoris MG1363 4798527 YP_001031874.1 CDS llmg_0524 NC_009004.1 523744 524346 D hypothetical protein 523744..524346 Lactococcus lactis subsp. cremoris MG1363 4797378 YP_001031875.1 CDS llmg_0525 NC_009004.1 524418 524612 D hypothetical protein 524418..524612 Lactococcus lactis subsp. cremoris MG1363 4797553 YP_001031876.1 CDS llmg_0526 NC_009004.1 524622 525887 D hypothetical protein 524622..525887 Lactococcus lactis subsp. cremoris MG1363 4798948 YP_001031877.1 CDS llmg_0527 NC_009004.1 526116 526460 D hypothetical protein 526116..526460 Lactococcus lactis subsp. cremoris MG1363 4798954 YP_001031878.1 CDS clpE NC_009004.1 526506 528752 D ATPase associated with various cellular activities (AAA); High confidence in function and specificity; ATP-dependent Clp protease ATP-binding subunit clpE 526506..528752 Lactococcus lactis subsp. cremoris MG1363 4797303 YP_001031879.1 CDS llmg_0529 NC_009004.1 528887 529357 R Protein of unknown function UPF0074, rrf2_super: rrf2 family protein; Family membership; transcriptional regulator complement(528887..529357) Lactococcus lactis subsp. cremoris MG1363 4796958 YP_001031880.1 CDS gapA NC_009004.1 529583 530596 D Glyceraldehyde-3-phosphate dehydrogenase, type I; High confidence in function and specificity; glyceraldehyde 3-phosphate dehydrogenase 529583..530596 Lactococcus lactis subsp. cremoris MG1363 4797280 YP_001031881.1 CDS llmg_0531 NC_009004.1 530629 530805 R hypothetical protein complement(530629..530805) Lactococcus lactis subsp. cremoris MG1363 4797681 YP_001031882.1 CDS def NC_009004.1 530821 531456 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(530821..531456) Lactococcus lactis subsp. cremoris MG1363 4798299 YP_001031883.1 CDS nudH NC_009004.1 531611 532066 D hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 531611..532066 Lactococcus lactis subsp. cremoris MG1363 4798048 YP_001031884.1 CDS uvrB NC_009004.1 532077 534155 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 532077..534155 Lactococcus lactis subsp. cremoris MG1363 4798741 YP_001031885.1 CDS gltS NC_009004.1 534338 535159 D Bacterial extracellular solute-binding protein, family 3; High confidence in function and specificity; arginine/ornithine ABC transporter substrate-binding protein 534338..535159 Lactococcus lactis subsp. cremoris MG1363 4797326 YP_001031886.1 CDS argE NC_009004.1 535174 536295 D High confidence in function and specificity; acetylornithine deacetylase 535174..536295 Lactococcus lactis subsp. cremoris MG1363 4798832 YP_001031887.1 CDS llmg_0538 NC_009004.1 536347 536802 R CDS; (3R)-hydroxymyristoyl-ACP dehydratase complement(536347..536802) Lactococcus lactis subsp. cremoris MG1363 4799047 YP_001031888.1 CDS fabI NC_009004.1 537078 537830 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 537078..537830 Lactococcus lactis subsp. cremoris MG1363 4798098 YP_001031889.1 CDS oxaA2 NC_009004.1 538093 539055 R involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor complement(538093..539055) Lactococcus lactis subsp. cremoris MG1363 4796589 YP_001031890.1 CDS pgmA NC_009004.1 539230 539988 R HAD-SF-IIB: HAD-superfamily hydrolase, subfamily IIB; High confidence in function and specificity; alpha-phosphoglucomutase complement(539230..539988) Lactococcus lactis subsp. cremoris MG1363 4799082 YP_001031891.1 CDS llmg_0542 NC_009004.1 540083 540673 R hypothetical protein complement(540083..540673) Lactococcus lactis subsp. cremoris MG1363 4798394 YP_001031892.1 CDS dfpA NC_009004.1 540690 541226 R decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase complement(540690..541226) Lactococcus lactis subsp. cremoris MG1363 4798032 YP_001031893.1 CDS dfpB NC_009004.1 541219 541914 R (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity; phosphopantothenate--cysteine ligase complement(541219..541914) Lactococcus lactis subsp. cremoris MG1363 4798892 YP_001031894.1 CDS xylH NC_009004.1 542061 542246 R 4-oxalocrotonate tautomerase complement(542061..542246) Lactococcus lactis subsp. cremoris MG1363 4798895 YP_001031895.1 CDS ctpE NC_009004.1 542442 544769 D ATPase-IIIA_H: plasma-membrane proton-efflux P-type ATPase; High confidence in function and specificity; cation transporter E1-E2 family ATPase 542442..544769 Lactococcus lactis subsp. cremoris MG1363 4798021 YP_001031896.1 CDS llmg_0548 NC_009004.1 544801 544968 D Conserved hypothetical protein; hypothetical protein 544801..544968 Lactococcus lactis subsp. cremoris MG1363 4798839 YP_001031897.1 CDS tnp981 NC_009004.1 545001 545840 R Integrase core domain; High confidence in function and specificity; transposase for insertion sequence element IS981A complement(545001..545840) Lactococcus lactis subsp. cremoris MG1363 4797534 YP_001031898.1 CDS llmg_0550 NC_009004.1 545852 546112 R transposase helper protein for IS981; hypothetical protein complement(545852..546112) Lactococcus lactis subsp. cremoris MG1363 4797337 YP_001031899.1 CDS llmg_0551 NC_009004.1 546237 546833 D hypothetical protein 546237..546833 Lactococcus lactis subsp. cremoris MG1363 4797599 YP_001031900.1 CDS llmg_0552 NC_009004.1 546982 547338 D Conserved hypothetical protein; glyoxylase 546982..547338 Lactococcus lactis subsp. cremoris MG1363 4797545 YP_001031901.1 CDS llmg_0553 NC_009004.1 547560 547844 D contains a dimeric alpha-beta barrel domain; hypothetical protein 547560..547844 Lactococcus lactis subsp. cremoris MG1363 4797607 YP_001031902.1 CDS tnp905 NC_009004.1 548155 549330 R High confidence in function and specificity; transposase for insertion sequence element IS905B complement(548155..549330) Lactococcus lactis subsp. cremoris MG1363 4798745 YP_001031903.1 CDS tdk NC_009004.1 549717 550286 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 549717..550286 Lactococcus lactis subsp. cremoris MG1363 4797965 YP_001031904.1 CDS llmg_0556 NC_009004.1 550297 550740 D hypothetical protein 550297..550740 Lactococcus lactis subsp. cremoris MG1363 4798761 YP_001031905.1 CDS prfA NC_009004.1 550758 551831 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 550758..551831 Lactococcus lactis subsp. cremoris MG1363 4798733 YP_001031906.1 CDS llmg_0558 NC_009004.1 551831 552358 D hypothetical protein 551831..552358 Lactococcus lactis subsp. cremoris MG1363 4797127 YP_001031907.1 CDS llmg_0559 NC_009004.1 552428 553183 D Nitroreductase; Family membership; NADPH-flavin oxidoreductase 552428..553183 Lactococcus lactis subsp. cremoris MG1363 4798593 YP_001031908.1 CDS hemK NC_009004.1 553288 554100 D Protein-glutamine N- methyltransferase; High confidence in function and specificity; protoporphyrinogen oxidase 553288..554100 Lactococcus lactis subsp. cremoris MG1363 4798586 YP_001031909.1 CDS llmg_0561 NC_009004.1 554134 554598 D GCN5-related N-acetyltransferase, Acetyltransferase (GNAT) family; Family membership; acetyltransferase 554134..554598 Lactococcus lactis subsp. cremoris MG1363 4797562 YP_001031910.1 CDS llmg_0562 NC_009004.1 554595 555515 D TIGR00057: Sua5/YciO/YrdC/YwlC family protein; Family membership; translation factor 554595..555515 Lactococcus lactis subsp. cremoris MG1363 4798061 YP_001031911.1 CDS glyA NC_009004.1 555748 556995 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 555748..556995 Lactococcus lactis subsp. cremoris MG1363 4798116 YP_001031912.1 CDS llmg_0564 NC_009004.1 557176 557778 D Similar to pneumococcal vaccine antigen A; Specificity unclear; soluble lytic murein transglycosylase 557176..557778 Lactococcus lactis subsp. cremoris MG1363 4798729 YP_001031913.1 CDS serC NC_009004.1 557905 559002 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 557905..559002 Lactococcus lactis subsp. cremoris MG1363 4797974 YP_001031914.1 CDS serA NC_009004.1 558999 560195 D D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity; D-3-phosphoglycerate dehydrogenase 558999..560195 Lactococcus lactis subsp. cremoris MG1363 4796833 YP_001031915.1 CDS serB NC_009004.1 560241 560903 D High confidence in function and specificity; SerB protein 560241..560903 Lactococcus lactis subsp. cremoris MG1363 4797214 YP_001031916.1 CDS llmg_0568 NC_009004.1 560940 561233 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(560940..561233) Lactococcus lactis subsp. cremoris MG1363 4797202 YP_001031917.1 CDS spoU NC_009004.1 561345 562103 D 23S rRNA (guanosine-2'-O-)-methyltransferase, rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3; High confidence in function and specificity; rRNA methyltransferase 561345..562103 Lactococcus lactis subsp. cremoris MG1363 4797838 YP_001031918.1 CDS llmg_0571 NC_009004.1 562315 562704 R contains RmlC-like cupin domain; Family membership; hypothetical protein complement(562315..562704) Lactococcus lactis subsp. cremoris MG1363 4796850 YP_001031919.1 CDS llmg_0572 NC_009004.1 563010 563357 D HTH-type transcriptional regulator, DNA binding; Family membership; MerR family transcriptional regulator 563010..563357 Lactococcus lactis subsp. cremoris MG1363 4796845 YP_001031920.1 CDS llmg_0573 NC_009004.1 563371 563697 D Similar to inorganic pyrophosphatase; Function unclear; hypothetical protein 563371..563697 Lactococcus lactis subsp. cremoris MG1363 4798107 YP_001031921.1 CDS fld NC_009004.1 563889 564332 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(563889..564332) Lactococcus lactis subsp. cremoris MG1363 4797442 YP_001031922.1 CDS llmg_0576 NC_009004.1 566198 566827 D contains Homeodomain-like domain; Family membership; TetR family transcriptional regulator 566198..566827 Lactococcus lactis subsp. cremoris MG1363 4797518 YP_001031923.1 CDS pepM NC_009004.1 567107 567961 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 567107..567961 Lactococcus lactis subsp. cremoris MG1363 4798712 YP_001031924.1 CDS llmg_0578 NC_009004.1 567981 568886 D Ribonuclease BN-like family; Function unclear; tRNA-processing ribonuclease BN 567981..568886 Lactococcus lactis subsp. cremoris MG1363 4798146 YP_001031925.1 CDS llmg_0579 NC_009004.1 568989 569435 R GtrA-like protein; Conserved hypothetical protein; hypothetical protein complement(568989..569435) Lactococcus lactis subsp. cremoris MG1363 4798572 YP_001031926.1 CDS llmg_0581 NC_009004.1 569967 570143 D hypothetical protein 569967..570143 Lactococcus lactis subsp. cremoris MG1363 4798704 YP_001031927.1 CDS ptsK NC_009004.1 570276 571208 D catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 570276..571208 Lactococcus lactis subsp. cremoris MG1363 4798577 YP_001031928.1 CDS lgt NC_009004.1 571270 572055 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 571270..572055 Lactococcus lactis subsp. cremoris MG1363 4797708 YP_001031929.1 CDS llmg_0584 NC_009004.1 572222 572641 D Bacterial protein of unknown function DUF948, general stress protein; hypothetical protein 572222..572641 Lactococcus lactis subsp. cremoris MG1363 4797638 YP_001031930.1 CDS llmg_0585 NC_009004.1 572671 573231 D hypothetical protein 572671..573231 Lactococcus lactis subsp. cremoris MG1363 4798569 YP_001031931.1 CDS gnd NC_009004.1 573365 574783 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 573365..574783 Lactococcus lactis subsp. cremoris MG1363 4798708 YP_001031932.1 CDS kupB NC_009004.1 577201 579216 D K+ potassium transporter; Conserved hypothetical protein; potassium transport system protein kupB 577201..579216 Lactococcus lactis subsp. cremoris MG1363 4796720 YP_001031933.1 CDS llmg_0589 NC_009004.1 579269 579439 R hypothetical protein complement(579269..579439) Lactococcus lactis subsp. cremoris MG1363 4797612 YP_001031934.1 CDS llmg_0590 NC_009004.1 579634 580299 D Protein of unknown function DUF161, Uncharacterized BCR, YitT family COG1284; Conserved hypothetical protein; hypothetical protein 579634..580299 Lactococcus lactis subsp. cremoris MG1363 4798012 YP_001031935.1 CDS miaA NC_009004.1 580430 581314 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 580430..581314 Lactococcus lactis subsp. cremoris MG1363 4796811 YP_001031936.1 CDS llmg_0592 NC_009004.1 581460 582128 D Function unclear; hypothetical protein 581460..582128 Lactococcus lactis subsp. cremoris MG1363 4798070 YP_001031937.1 CDS llmg_0593 NC_009004.1 582293 583195 D SPFH domain / Band 7 family, Similar to several eukaryotic hypersensitive-induced response proteins; Family membership; prohibitin/stomatin like protein 582293..583195 Lactococcus lactis subsp. cremoris MG1363 4798478 YP_001031938.1 CDS ps201 NC_009004.1 583444 584460 R DNA breaking-rejoining enzyme, catalytic core, site- specific recombinase, phage integrase; High confidence in function and specificity; phage integrase complement(583444..584460) Lactococcus lactis subsp. cremoris MG1363 4797418 YP_001031939.1 CDS ps202 NC_009004.1 584681 585172 R Similar to ps202 from IL1403, phage associated; hypothetical protein complement(584681..585172) Lactococcus lactis subsp. cremoris MG1363 4798011 YP_001031940.1 CDS ps203 NC_009004.1 585448 585657 R hypothetical protein complement(585448..585657) Lactococcus lactis subsp. cremoris MG1363 4798434 YP_001031941.1 CDS ps204 NC_009004.1 585725 585976 R Similar to pi358 from IL1403, Phage associated; hypothetical protein complement(585725..585976) Lactococcus lactis subsp. cremoris MG1363 4797908 YP_001031942.1 CDS ps205 NC_009004.1 586213 586395 R phage associated; cI-like repressor complement(586213..586395) Lactococcus lactis subsp. cremoris MG1363 4798045 YP_001031943.1 CDS llmg_0599 NC_009004.1 586683 588290 D Region start changed from 586756 to 586684 (72 bases); hypothetical protein 586683..588290 Lactococcus lactis subsp. cremoris MG1363 4797818 YP_001031944.1 CDS llmg_0600 NC_009004.1 588208 589146 D Glycosyl transferase, family 2; High confidence in function and specificity; glycosyl transferase family protein 588208..589146 Lactococcus lactis subsp. cremoris MG1363 4798487 YP_001031945.1 CDS llmg_0601 NC_009004.1 589412 589903 R hypothetical protein complement(589412..589903) Lactococcus lactis subsp. cremoris MG1363 4798082 YP_001031946.1 CDS llmg_0602 NC_009004.1 589916 590290 R Disruption induces osmosensitive phenotype; hypothetical protein complement(589916..590290) Lactococcus lactis subsp. cremoris MG1363 4797623 YP_001031947.1 CDS llmg_0603 NC_009004.1 590635 590982 R Similar to Lactococcus bacteriophage repressor; Function unclear; HTH-type transcriptional regulator complement(590635..590982) Lactococcus lactis subsp. cremoris MG1363 4797614 YP_001031948.1 CDS llmg_0604 NC_009004.1 591748 592671 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 591748..592671 Lactococcus lactis subsp. cremoris MG1363 4796990 YP_001031949.1 CDS llmg_0605 NC_009004.1 592616 593365 D Oxidoreductase, Short-chain dehydrogenase; Family membership; oxidoreductase 592616..593365 Lactococcus lactis subsp. cremoris MG1363 4798003 YP_001031950.1 CDS recJ NC_009004.1 593538 595766 D DHH family; High confidence in function and specificity; ssDNA-binding protein 593538..595766 Lactococcus lactis subsp. cremoris MG1363 4799023 YP_001031951.1 CDS apt NC_009004.1 595890 596402 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 595890..596402 Lactococcus lactis subsp. cremoris MG1363 4796716 YP_001031952.1 CDS rpoE NC_009004.1 596618 597184 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 596618..597184 Lactococcus lactis subsp. cremoris MG1363 4798525 YP_001031953.1 CDS pabC NC_009004.1 597323 598960 D TIGR00247: conserved hypothetical protein TIGR00247; aminodeoxychorismate lyase 597323..598960 Lactococcus lactis subsp. cremoris MG1363 4797538 YP_001031954.1 CDS greA NC_009004.1 599021 599491 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 599021..599491 Lactococcus lactis subsp. cremoris MG1363 4799077 YP_001031955.1 CDS llmg_0611 NC_009004.1 599583 600140 D Family membership; hypothetical protein 599583..600140 Lactococcus lactis subsp. cremoris MG1363 4798731 YP_001031956.1 CDS llmg_0612 NC_009004.1 601031 601321 D transposase helper protein for IS904; hypothetical protein 601031..601321 Lactococcus lactis subsp. cremoris MG1363 4797522 YP_001031957.1 CDS llmg_0613 NC_009004.1 601417 602178 D Region start changed from 601339 to 601417 (-78 bases); transposase for insertion sequence element IS904B 601417..602178 Lactococcus lactis subsp. cremoris MG1363 4796780 YP_001031958.1 CDS ctsR NC_009004.1 602409 602864 D Firmicute transcriptional repressor of class III stress genes; High confidence in function and specificity; transcriptional regulator ctsR 602409..602864 Lactococcus lactis subsp. cremoris MG1363 4798658 YP_001031959.1 CDS clpC NC_009004.1 602854 605304 D High confidence in function and specificity; ATP-dependent Clp protease ATP-binding subunit 602854..605304 Lactococcus lactis subsp. cremoris MG1363 4798843 YP_001031960.1 CDS yfiA NC_009004.1 605439 605996 D Sigma 54 modulation protein/ribosomal protein S30EA, Similar to yfiA in E. Coli, ribosomal subunit interface protein; Specificity unclear; sigma 54 modulation protein 605439..605996 Lactococcus lactis subsp. cremoris MG1363 4797022 YP_001031961.1 CDS eno NC_009004.1 606184 607485 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 606184..607485 Lactococcus lactis subsp. cremoris MG1363 4797432 YP_001031962.1 CDS xerD NC_009004.1 607574 608509 D DNA breaking-rejoining enzyme, catalytic core, Phage integrase; Conserved hypothetical protein; integrase-recombinase 607574..608509 Lactococcus lactis subsp. cremoris MG1363 4796855 YP_001031963.1 CDS llmg_0619 NC_009004.1 608636 609268 D Also present on plasmid pJW394; Conserved hypothetical protein; hypothetical protein 608636..609268 Lactococcus lactis subsp. cremoris MG1363 4797946 YP_001031964.1 CDS tnp981 NC_009004.1 610648 611487 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981B complement(610648..611487) Lactococcus lactis subsp. cremoris MG1363 4797894 YP_001031965.1 CDS llmg_0622 NC_009004.1 611499 611759 R transposase helper protein for IS981; hypothetical protein complement(611499..611759) Lactococcus lactis subsp. cremoris MG1363 4797338 YP_001031966.1 CDS abiP NC_009004.1 611839 612519 D High confidence in function and specificity; abortive phage resistance protein abiP 611839..612519 Lactococcus lactis subsp. cremoris MG1363 4796759 YP_001031967.1 CDS llmg_0624 NC_009004.1 613053 613724 R Specificity unclear; ABC transporter ATP-binding protein complement(613053..613724) Lactococcus lactis subsp. cremoris MG1363 4797502 YP_001031968.1 CDS llmg_0625 NC_009004.1 613726 614799 R Protein of unknown function DUF214; Conserved hypothetical protein; ABC transporter permease complement(613726..614799) Lactococcus lactis subsp. cremoris MG1363 4798809 YP_001031969.1 CDS llmg_0626 NC_009004.1 614811 615380 R Homeodomain-like; transcriptional regulator complement(614811..615380) Lactococcus lactis subsp. cremoris MG1363 4796859 YP_001031970.1 CDS fadD NC_009004.1 615570 617093 R Acetyl-coenzyme A synthetase; High confidence in function and specificity; long-chain acyl-CoA synthetase complement(615570..617093) Lactococcus lactis subsp. cremoris MG1363 4797698 YP_001031971.1 CDS llmg_0628 NC_009004.1 617287 618204 D Similar to Mg2+ transporter protein, CorA-like; Specificity unclear; divalent cation transport-related protein 617287..618204 Lactococcus lactis subsp. cremoris MG1363 4796691 YP_001031972.1 CDS pfl NC_009004.1 618464 620827 D Pyruvate formate-lyase; High confidence in function and specificity; formate acetyltransferase 618464..620827 Lactococcus lactis subsp. cremoris MG1363 4797717 YP_001031973.1 CDS coaE NC_009004.1 620956 621615 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 620956..621615 Lactococcus lactis subsp. cremoris MG1363 4798580 YP_001031974.1 CDS pmrA NC_009004.1 621618 622835 D Major Facilitator Superfamily; High confidence in function and specificity; multidrug resistance efflux pump 621618..622835 Lactococcus lactis subsp. cremoris MG1363 4797832 YP_001031975.1 CDS rpmG NC_009004.1 622832 622978 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 622832..622978 Lactococcus lactis subsp. cremoris MG1363 4797829 YP_001031976.1 CDS ftsW1 NC_009004.1 623355 624617 D rodA_shape: rod shape-determining protein RodA; High confidence in function and specificity; cell division protein FtsW 623355..624617 Lactococcus lactis subsp. cremoris MG1363 4798811 YP_001031977.1 CDS pycA NC_009004.1 624722 628135 D biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 624722..628135 Lactococcus lactis subsp. cremoris MG1363 4798789 YP_001031978.1 CDS gltA NC_009004.1 628261 629586 D catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 628261..629586 Lactococcus lactis subsp. cremoris MG1363 4797704 YP_001031979.1 CDS citB NC_009004.1 629583 632129 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 629583..632129 Lactococcus lactis subsp. cremoris MG1363 4798330 YP_001031980.1 CDS icd NC_009004.1 632149 633387 D High confidence in function and specificity; isocitrate dehydrogenase 632149..633387 Lactococcus lactis subsp. cremoris MG1363 4796910 YP_001031981.1 CDS clpP NC_009004.1 633447 634046 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(633447..634046) Lactococcus lactis subsp. cremoris MG1363 4796752 YP_001031982.1 CDS llmg_0639 NC_009004.1 634242 634772 D hypothetical protein 634242..634772 Lactococcus lactis subsp. cremoris MG1363 4796569 YP_001031983.1 CDS spxA NC_009004.1 634943 635341 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 634943..635341 Lactococcus lactis subsp. cremoris MG1363 4798366 YP_001031984.1 CDS llmg_0641 NC_009004.1 635494 635628 R hypothetical protein complement(635494..635628) Lactococcus lactis subsp. cremoris MG1363 4798059 YP_001031985.1 CDS llmg_0642 NC_009004.1 635725 636888 R Conserved hypothetical protein; hypothetical protein complement(635725..636888) Lactococcus lactis subsp. cremoris MG1363 4798392 YP_001031986.1 CDS pacL NC_009004.1 637215 639971 D Specificity unclear; cation transporter E1-E2 family ATPase 637215..639971 Lactococcus lactis subsp. cremoris MG1363 4798401 YP_001031987.1 CDS llmg_0644 NC_009004.1 640489 640968 D hypothetical protein 640489..640968 Lactococcus lactis subsp. cremoris MG1363 4799075 YP_001031988.1 CDS llmg_0645 NC_009004.1 640986 641516 D Conserved hypothetical protein; hypothetical protein 640986..641516 Lactococcus lactis subsp. cremoris MG1363 4796782 YP_001031989.1 CDS icaA NC_009004.1 641521 642735 D Glycosyl transferase, family 2; Function unclear; intercellular adhesion protein A 641521..642735 Lactococcus lactis subsp. cremoris MG1363 4797189 YP_001031990.1 CDS tnp981 NC_009004.1 643149 643988 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981C complement(643149..643988) Lactococcus lactis subsp. cremoris MG1363 4797663 YP_001031991.1 CDS llmg_0648 NC_009004.1 644000 644260 R transposase helper protein for IS981; Family membership; hypothetical protein complement(644000..644260) Lactococcus lactis subsp. cremoris MG1363 4797332 YP_001031992.1 CDS icaB NC_009004.1 644291 645115 D Similar to polysaccharide deacetylase; High confidence in function and specificity; intercellular adhesion protein B 644291..645115 Lactococcus lactis subsp. cremoris MG1363 4796779 YP_001031993.1 CDS brnQ NC_009004.1 645202 646551 R branched-chain amino acid:cation transporter LIVCS family; High confidence in function and specificity; branched chain amino acid ABC transporter carrier protein complement(645202..646551) Lactococcus lactis subsp. cremoris MG1363 4797732 YP_001031994.1 CDS llmg_0651 NC_009004.1 646767 647039 R Conserved hypothetical protein; acetyltransferase complement(646767..647039) Lactococcus lactis subsp. cremoris MG1363 4797683 YP_001031995.1 CDS llmg_0652 NC_009004.1 647207 647968 R Region start changed from 648046 to 647968 (-78 bases); transposase for insertion sequence element IS904C complement(647207..647968) Lactococcus lactis subsp. cremoris MG1363 4797427 YP_001031996.1 CDS llmg_0653 NC_009004.1 648202 648354 R transposase helper protein for insertion sequence element IS904; hypothetical protein complement(648202..648354) Lactococcus lactis subsp. cremoris MG1363 4796713 YP_001031997.1 CDS llmg_0654 NC_009004.1 648490 649110 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS-LL6B complement(648490..649110) Lactococcus lactis subsp. cremoris MG1363 4797568 YP_001031998.1 CDS llmg_0655 NC_009004.1 649272 649547 R contains Homeodomain-like region; Family membership; transposase complement(649272..649547) Lactococcus lactis subsp. cremoris MG1363 4797897 YP_001031999.1 CDS tnp982 NC_009004.1 649642 650532 R Transposase DDE domain; Family membership; transposase for insertion sequence element IS982B complement(649642..650532) Lactococcus lactis subsp. cremoris MG1363 4797879 YP_001032000.1 CDS hsdR NC_009004.1 650883 654059 D Specificity unclear; type I restriction-modification system restriction subunit 650883..654059 Lactococcus lactis subsp. cremoris MG1363 4797901 YP_001032001.1 CDS hsdM NC_009004.1 654041 655678 D Type I restriction modification system, M subunit; Specificity unclear; type I site-specific deoxyribonuclease 654041..655678 Lactococcus lactis subsp. cremoris MG1363 4796743 YP_001032002.1 CDS hsdS NC_009004.1 655644 656894 D Type I restriction modification DNA specificity subunit; Specificity unclear; specificity determinant HsdS 655644..656894 Lactococcus lactis subsp. cremoris MG1363 4796694 YP_001032003.1 CDS llmg_0661 NC_009004.1 657080 658030 D Mg2+ transporter protein, CorA-like; Specificity unclear; CorA like magnesium and cobalt transport protein 657080..658030 Lactococcus lactis subsp. cremoris MG1363 4797705 YP_001032004.1 CDS pcp NC_009004.1 659931 660578 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 659931..660578 Lactococcus lactis subsp. cremoris MG1363 4797823 YP_001032005.1 CDS amd NC_009004.1 660769 661965 R Peptidase M20/M25/M40; High confidence in function and specificity; amidase complement(660769..661965) Lactococcus lactis subsp. cremoris MG1363 4798142 YP_001032006.1 CDS oxlT NC_009004.1 663030 664286 D Major facilitator superfamily; High confidence in function and specificity; oxalate/formate antiporter 663030..664286 Lactococcus lactis subsp. cremoris MG1363 4797896 YP_001032007.1 CDS llmg_0668 NC_009004.1 665114 665431 D GCN5-related N-acetyltransferase; Family membership; hypothetical protein 665114..665431 Lactococcus lactis subsp. cremoris MG1363 4799081 YP_001032008.1 CDS llmg_0669 NC_009004.1 665705 665857 R hypothetical protein complement(665705..665857) Lactococcus lactis subsp. cremoris MG1363 4797920 YP_001032009.1 CDS llmg_0670 NC_009004.1 665908 666210 R hypothetical protein complement(665908..666210) Lactococcus lactis subsp. cremoris MG1363 4797943 YP_001032010.1 CDS llmg_0671 NC_009004.1 666207 666383 R TIGR01847: Bacteriocin-type signal sequence; hypothetical protein complement(666207..666383) Lactococcus lactis subsp. cremoris MG1363 4797259 YP_001032011.1 CDS llmg_0672 NC_009004.1 666858 666959 D hypothetical protein 666858..666959 Lactococcus lactis subsp. cremoris MG1363 4796657 YP_001032012.1 CDS llmg_0673 NC_009004.1 666946 667563 R hypothetical protein complement(666946..667563) Lactococcus lactis subsp. cremoris MG1363 4797317 YP_001032013.1 CDS tnp1297 NC_009004.1 667840 668520 R High confidence in function and specificity; transposase for insertion sequence element IS1297 complement(667840..668520) Lactococcus lactis subsp. cremoris MG1363 4798249 YP_001032014.1 CDS llmg_0675 NC_009004.1 668849 669088 D hypothetical protein 668849..669088 Lactococcus lactis subsp. cremoris MG1363 4797082 YP_001032015.1 CDS llmg_0676 NC_009004.1 669248 669745 R GCN5-related N-acetyltransferase, Acetyltransferase (GNAT) family; Family membership; acetyltransferase complement(669248..669745) Lactococcus lactis subsp. cremoris MG1363 4798519 YP_001032016.1 CDS llmg_0677 NC_009004.1 670033 670245 D hypothetical protein 670033..670245 Lactococcus lactis subsp. cremoris MG1363 4797937 YP_001032017.1 CDS llmg_0678 NC_009004.1 671109 671369 R transposase helper protein for IS981 complement(671109..671369) Lactococcus lactis subsp. cremoris MG1363 4797483 YP_001032018.1 CDS llmg_0679 NC_009004.1 671499 671690 D Conserved hypothetical protein; hypothetical protein 671499..671690 Lactococcus lactis subsp. cremoris MG1363 4796888 YP_001032019.1 CDS llmg_0680 NC_009004.1 671742 671918 D hypothetical protein 671742..671918 Lactococcus lactis subsp. cremoris MG1363 4796919 YP_001032020.1 CDS llmg_0681 NC_009004.1 672065 672550 D Lambda repressor-like, DNA-binding., Contains Helix- turn-helix domain; hypothetical protein 672065..672550 Lactococcus lactis subsp. cremoris MG1363 4796981 YP_001032021.1 CDS tnp712 NC_009004.1 672799 674022 D Integrase, catalytic region; Specificity unclear; transposase for insertion sequence element IS712B 672799..674022 Lactococcus lactis subsp. cremoris MG1363 4798226 YP_001032022.1 CDS llmg_0683 NC_009004.1 674034 674792 D PF01695: IstB-like ATP-binding protein; Function unclear; transposase helper protein for IS712B 674034..674792 Lactococcus lactis subsp. cremoris MG1363 4798223 YP_001032023.1 CDS tnp981 NC_009004.1 675028 675867 D Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981E 675028..675867 Lactococcus lactis subsp. cremoris MG1363 4797462 YP_001032024.1 CDS llmg_0685 NC_009004.1 676555 676701 D hypothetical protein 676555..676701 Lactococcus lactis subsp. cremoris MG1363 4797321 YP_001032025.1 CDS llmg_0686 NC_009004.1 677108 677389 D hypothetical protein 677108..677389 Lactococcus lactis subsp. cremoris MG1363 4797028 YP_001032026.1 CDS llmg_0687 NC_009004.1 677973 678140 D Contains bacteriocin-type signal sequence; hypothetical protein 677973..678140 Lactococcus lactis subsp. cremoris MG1363 4796952 YP_001032027.1 CDS llmg_0688 NC_009004.1 678147 678449 D hypothetical protein 678147..678449 Lactococcus lactis subsp. cremoris MG1363 4796732 YP_001032028.1 CDS llmg_0689 NC_009004.1 678500 678628 D hypothetical protein 678500..678628 Lactococcus lactis subsp. cremoris MG1363 4796991 YP_001032029.1 CDS llmg_0690 NC_009004.1 678701 680563 D E1-E2 ATPase; High confidence in function and specificity; heavy metal-translocating P-type ATPase 678701..680563 Lactococcus lactis subsp. cremoris MG1363 4796688 YP_001032030.1 CDS llmg_0691 NC_009004.1 680949 681047 D hypothetical protein 680949..681047 Lactococcus lactis subsp. cremoris MG1363 4797070 YP_001032031.1 CDS llmg_0692 NC_009004.1 681269 681496 D Contains Heavy-Metal-Associated (HMA) domain; Specificity unclear; hypothetical protein 681269..681496 Lactococcus lactis subsp. cremoris MG1363 4797091 YP_001032032.1 CDS llmg_0693 NC_009004.1 681542 682090 D Ferritin/ribonucleotide reductase-like; stress induced DNA binding protein 681542..682090 Lactococcus lactis subsp. cremoris MG1363 4796794 YP_001032033.1 CDS flpB NC_009004.1 682176 682865 D Cyclic nucleotide-binding domain; Conserved hypothetical protein; transcriptional regulator FNR like protein B 682176..682865 Lactococcus lactis subsp. cremoris MG1363 4797002 YP_001032034.1 CDS llmg_0695 NC_009004.1 683191 683319 D hypothetical protein 683191..683319 Lactococcus lactis subsp. cremoris MG1363 4798137 YP_001032035.1 CDS llmg_0696 NC_009004.1 683306 683479 R hypothetical protein complement(683306..683479) Lactococcus lactis subsp. cremoris MG1363 4798022 YP_001032036.1 CDS oppD NC_009004.1 683542 684558 D High confidence in function and specificity; oligopeptide transport ATP-binding protein oppD 683542..684558 Lactococcus lactis subsp. cremoris MG1363 4797010 YP_001032037.1 CDS oppF NC_009004.1 684555 685514 D High confidence in function and specificity; oligopeptide transport ATP-binding protein oppF 684555..685514 Lactococcus lactis subsp. cremoris MG1363 4799087 YP_001032038.1 CDS oppB NC_009004.1 685495 686454 D Binding-protein-dependent transport systems inner membrane component; High confidence in function and specificity; peptide transport system permease oppB 685495..686454 Lactococcus lactis subsp. cremoris MG1363 4799085 YP_001032039.1 CDS oppC NC_009004.1 686464 687348 D Binding-protein-dependent transport systems inner membrane component; High confidence in function and specificity; oligopeptide transport system permease oppC 686464..687348 Lactococcus lactis subsp. cremoris MG1363 4799091 YP_001032040.1 CDS oppA NC_009004.1 687458 689260 D Bacterial extracellular solute-binding protein, family 5; High confidence in function and specificity; oligopeptide-binding protein oppA 687458..689260 Lactococcus lactis subsp. cremoris MG1363 4799089 YP_001032041.1 CDS pepO NC_009004.1 689385 691268 D Peptidase M13; High confidence in function and specificity; endopeptidase O 689385..691268 Lactococcus lactis subsp. cremoris MG1363 4799093 YP_001032042.1 CDS tnp1675 NC_009004.1 691571 692890 D Transposase DDE domain; Specificity unclear; transposase 691571..692890 Lactococcus lactis subsp. cremoris MG1363 4798134 YP_001032043.1 CDS llmg_0704 NC_009004.1 693318 693521 D hypothetical protein 693318..693521 Lactococcus lactis subsp. cremoris MG1363 4798344 YP_001032044.1 CDS llmg_0705 NC_009004.1 693514 693837 D hypothetical protein 693514..693837 Lactococcus lactis subsp. cremoris MG1363 4796758 YP_001032045.1 CDS llmg_0706 NC_009004.1 694246 694527 D hypothetical protein 694246..694527 Lactococcus lactis subsp. cremoris MG1363 4798195 YP_001032046.1 CDS llmg_0707 NC_009004.1 694698 695015 R hypothetical protein complement(694698..695015) Lactococcus lactis subsp. cremoris MG1363 4796810 YP_001032047.1 CDS llmg_0708 NC_009004.1 694993 695268 R hypothetical protein complement(694993..695268) Lactococcus lactis subsp. cremoris MG1363 4796754 YP_001032048.1 CDS llmg_0709 NC_009004.1 695498 695842 D Family membership; PadR-like family transcriptional regulator 695498..695842 Lactococcus lactis subsp. cremoris MG1363 4799011 YP_001032049.1 CDS llmg_0710 NC_009004.1 695839 696666 D Conserved hypothetical protein; hypothetical protein 695839..696666 Lactococcus lactis subsp. cremoris MG1363 4797880 YP_001032050.1 CDS tnpR NC_009004.1 696901 697455 D High confidence in function and specificity; DNA-invertase/resolvase 696901..697455 Lactococcus lactis subsp. cremoris MG1363 4796634 YP_001032051.1 CDS llmg_0712 NC_009004.1 697799 698404 R Conserved hypothetical protein; hypothetical protein complement(697799..698404) Lactococcus lactis subsp. cremoris MG1363 4798020 YP_001032052.1 CDS llmg_0713 NC_009004.1 698417 698596 R hypothetical protein complement(698417..698596) Lactococcus lactis subsp. cremoris MG1363 4798087 YP_001032053.1 CDS tnp981 NC_009004.1 698693 699532 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981F complement(698693..699532) Lactococcus lactis subsp. cremoris MG1363 4796938 YP_001032054.1 CDS llmg_0715 NC_009004.1 699794 700417 D hypothetical protein 699794..700417 Lactococcus lactis subsp. cremoris MG1363 4797422 YP_001032055.1 CDS llmg_0716 NC_009004.1 700636 700923 D hypothetical protein 700636..700923 Lactococcus lactis subsp. cremoris MG1363 4797133 YP_001032056.1 CDS tnp946 NC_009004.1 701028 701708 R Integrase, catalytic region, also known as iso- ISS1; High confidence in function and specificity; transposase for insertion sequence element IS946 complement(701028..701708) Lactococcus lactis subsp. cremoris MG1363 4798041 YP_001032057.1 CDS llmg_0718 NC_009004.1 702975 703628 D Similar to molybdenum cofactor biosynthesis protein; Conserved hypothetical protein; nucleotide binding protein 702975..703628 Lactococcus lactis subsp. cremoris MG1363 4797843 YP_001032058.1 CDS llmg_0719 NC_009004.1 703621 704781 D Similar to peptide ABC-type transporters; Function unclear; ABC transporter substrate-binding protein 703621..704781 Lactococcus lactis subsp. cremoris MG1363 4796970 YP_001032059.1 CDS llmg_0720 NC_009004.1 704818 705078 D transposase helper protein for IS981; hypothetical protein 704818..705078 Lactococcus lactis subsp. cremoris MG1363 4797786 YP_001032060.1 CDS tnp981 NC_009004.1 705090 705929 D Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981G 705090..705929 Lactococcus lactis subsp. cremoris MG1363 4799112 YP_001032061.1 CDS serS NC_009004.1 706170 707441 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(706170..707441) Lactococcus lactis subsp. cremoris MG1363 4797292 YP_001032062.1 CDS llmg_0724 NC_009004.1 707840 708199 R Domain of unknown function (DUF956); hypothetical protein complement(707840..708199) Lactococcus lactis subsp. cremoris MG1363 4798638 YP_001032063.1 CDS llmg_0725 NC_009004.1 708350 709045 D Protein of unknown function DUF161, Uncharacterized BCR, YitT family COG1284; hypothetical protein 708350..709045 Lactococcus lactis subsp. cremoris MG1363 4797019 YP_001032064.1 CDS llmg_0726 NC_009004.1 709070 709453 R Protein of unknown function DUF956; hypothetical protein complement(709070..709453) Lactococcus lactis subsp. cremoris MG1363 4797032 YP_001032065.1 CDS ptnD NC_009004.1 709596 710519 R EIID-AGA: PTS system, mannose/fructose/sorbose family, IID component; High confidence in function and specificity; mannose-specific PTS system component IID complement(709596..710519) Lactococcus lactis subsp. cremoris MG1363 4796916 YP_001032066.1 CDS ptnC NC_009004.1 710538 711350 R EII-Sor: PTS system, mannose/fructose/sorbose family, IIC component; High confidence in function and specificity; mannose-specific PTS system component IIC complement(710538..711350) Lactococcus lactis subsp. cremoris MG1363 4798015 YP_001032067.1 CDS ptnAB NC_009004.1 711429 712418 R pts-sorbose: PTS system, mannose/fructose/sorbose family, IIB component; High confidence in function and specificity; PTS system mannose-specific transporter subunit IIAB complement(711429..712418) Lactococcus lactis subsp. cremoris MG1363 4798027 YP_001032068.1 CDS fer NC_009004.1 712688 712891 R 3Fe-4S ferredoxin; Conserved hypothetical protein; ferredoxin complement(712688..712891) Lactococcus lactis subsp. cremoris MG1363 4798620 YP_001032069.1 CDS llmg_0731 NC_009004.1 712938 713450 D Contains one Peptidoglycan-binding LysM domain; hypothetical protein 712938..713450 Lactococcus lactis subsp. cremoris MG1363 4796875 YP_001032070.1 CDS cmk NC_009004.1 713570 714232 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 713570..714232 Lactococcus lactis subsp. cremoris MG1363 4798164 YP_001032071.1 CDS llmg_0733 NC_009004.1 714312 715703 D lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain; High confidence in function and specificity; cell envelope-related transcriptional attenuator 714312..715703 Lactococcus lactis subsp. cremoris MG1363 4797320 YP_001032072.1 CDS llmg_0734 NC_009004.1 715942 716562 D Isochorismatase, Similar to amidases related to nicotinamidase; Family membership; amidase 715942..716562 Lactococcus lactis subsp. cremoris MG1363 4797016 YP_001032073.1 CDS llmg_0736 NC_009004.1 717923 718498 D Similar to predicted metal-dependent membrane protease; Conserved hypothetical protein; hypothetical protein 717923..718498 Lactococcus lactis subsp. cremoris MG1363 4797883 YP_001032074.1 CDS malG NC_009004.1 718629 719495 R High confidence in function and specificity; maltose ABC transporter permease malG complement(718629..719495) Lactococcus lactis subsp. cremoris MG1363 4798664 YP_001032075.1 CDS malF NC_009004.1 719501 720883 R High confidence in function and specificity; maltose transport system permease malF complement(719501..720883) Lactococcus lactis subsp. cremoris MG1363 4798442 YP_001032076.1 CDS malE NC_009004.1 720962 722191 R Maltotriose-binding protein precursor (Maltodextrin- binding protein); High confidence in function and specificity; maltose ABC transporter substrate binding protein complement(720962..722191) Lactococcus lactis subsp. cremoris MG1363 4798313 YP_001032077.1 CDS dexC NC_009004.1 722564 724318 D Cyclomaltodextrinase; High confidence in function and specificity; neopullulanase 722564..724318 Lactococcus lactis subsp. cremoris MG1363 4798284 YP_001032078.1 CDS dexA NC_009004.1 724633 726228 D High confidence in function and specificity; oligo-1,6-alpha-glucosidase 724633..726228 Lactococcus lactis subsp. cremoris MG1363 4798891 YP_001032079.1 CDS maa NC_009004.1 726255 726860 D High confidence in function and specificity; maltose O-acetyltransferase 726255..726860 Lactococcus lactis subsp. cremoris MG1363 4798887 YP_001032080.1 CDS amyY NC_009004.1 726850 728424 D High confidence in function and specificity; alpha-amylase 726850..728424 Lactococcus lactis subsp. cremoris MG1363 4796751 YP_001032081.1 CDS agl NC_009004.1 728467 730092 D High confidence in function and specificity; alpha-glucosidase 728467..730092 Lactococcus lactis subsp. cremoris MG1363 4797742 YP_001032082.1 CDS mapA NC_009004.1 730115 732370 D Glycosyl hydrolase 65 central catalytic domain; High confidence in function and specificity; maltose phosphorylase 730115..732370 Lactococcus lactis subsp. cremoris MG1363 4797676 YP_001032083.1 CDS malR NC_009004.1 732522 733496 D High confidence in function and specificity; maltose operon transcriptional repressor 732522..733496 Lactococcus lactis subsp. cremoris MG1363 4798764 YP_001032084.1 CDS llrF NC_009004.1 733674 734342 D Response regulator receiver domain; High confidence in function and specificity; two-component system regulator llrF 733674..734342 Lactococcus lactis subsp. cremoris MG1363 4798749 YP_001032085.1 CDS kinF NC_009004.1 734558 735928 D Histidine kinase; High confidence in function and specificity; sensor protein kinase kinF 734558..735928 Lactococcus lactis subsp. cremoris MG1363 4797659 YP_001032086.1 CDS dxsB NC_009004.1 736077 737819 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 736077..737819 Lactococcus lactis subsp. cremoris MG1363 4797671 YP_001032087.1 CDS llmg_0750 NC_009004.1 737939 738211 D Protein of unknown function DUF37; hypothetical protein 737939..738211 Lactococcus lactis subsp. cremoris MG1363 4799014 YP_001032088.1 CDS arb NC_009004.1 738330 739763 D required for arbutin uptake and metabolism; 6-phospho-beta-glucosidase 738330..739763 Lactococcus lactis subsp. cremoris MG1363 4797097 YP_001032089.1 CDS pip NC_009004.1 740024 742729 D High confidence in function and specificity; phage infection protein 740024..742729 Lactococcus lactis subsp. cremoris MG1363 4797230 YP_001032090.1 CDS ubiE NC_009004.1 742828 743568 D High confidence in function and specificity; ubiquinone/menaquinone biosynthesis methyltransferase 742828..743568 Lactococcus lactis subsp. cremoris MG1363 4796576 YP_001032091.1 CDS llmg_0754 NC_009004.1 743605 744438 D Transcriptional activator, Rgg/GadR/MutR family; Function unclear; Rgg family transcriptional regulator 743605..744438 Lactococcus lactis subsp. cremoris MG1363 4797827 YP_001032092.1 CDS llmg_0755 NC_009004.1 744506 744895 D hypothetical protein 744506..744895 Lactococcus lactis subsp. cremoris MG1363 4797057 YP_001032093.1 CDS llmg_0756 NC_009004.1 744892 745509 D hypothetical protein 744892..745509 Lactococcus lactis subsp. cremoris MG1363 4796896 YP_001032094.1 CDS llmg_0757 NC_009004.1 745499 745759 D hypothetical protein 745499..745759 Lactococcus lactis subsp. cremoris MG1363 4797533 YP_001032095.1 CDS eriC NC_009004.1 745928 747466 D High confidence in function and specificity; chloride channel protein 745928..747466 Lactococcus lactis subsp. cremoris MG1363 4798302 YP_001032096.1 CDS ubiA NC_009004.1 747491 748450 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(747491..748450) Lactococcus lactis subsp. cremoris MG1363 4796765 YP_001032097.1 CDS llmg_0760 NC_009004.1 749121 749720 D Transglycosylase-like domain; Family membership; transglycosylase 749121..749720 Lactococcus lactis subsp. cremoris MG1363 4798486 YP_001032098.1 CDS llmg_0761 NC_009004.1 749986 750966 R oxidoreductase, Gfo/Idh/MocA family; Family membership; oxidoreductase complement(749986..750966) Lactococcus lactis subsp. cremoris MG1363 4797459 YP_001032099.1 CDS udk NC_009004.1 751263 751883 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 751263..751883 Lactococcus lactis subsp. cremoris MG1363 4797841 YP_001032100.1 CDS eutD NC_009004.1 752099 753079 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 752099..753079 Lactococcus lactis subsp. cremoris MG1363 4797970 YP_001032101.1 CDS llmg_0764 NC_009004.1 753217 753609 D hypothetical protein 753217..753609 Lactococcus lactis subsp. cremoris MG1363 4799041 YP_001032102.1 CDS llmg_0765 NC_009004.1 753649 754434 R Cof-subfamily: Cof-like hydrolase; Family membership; hydrolase complement(753649..754434) Lactococcus lactis subsp. cremoris MG1363 4797909 YP_001032103.1 CDS ftsK NC_009004.1 754626 756893 D FtsK/SpoIIIE family; High confidence in function and specificity; DNA translocase FtsK 754626..756893 Lactococcus lactis subsp. cremoris MG1363 4796834 YP_001032104.1 CDS llmg_0767 NC_009004.1 756890 757468 D hypothetical protein 756890..757468 Lactococcus lactis subsp. cremoris MG1363 4796840 YP_001032105.1 CDS holA NC_009004.1 757470 758474 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 757470..758474 Lactococcus lactis subsp. cremoris MG1363 4797170 YP_001032106.1 CDS llmg_0769 NC_009004.1 758531 758917 D Family membership; DivIVA cell division initiation protein 758531..758917 Lactococcus lactis subsp. cremoris MG1363 4796763 YP_001032107.1 CDS llmg_0771 NC_009004.1 759553 760707 D Family membership; N-6 adenine-specific DNA methylase 759553..760707 Lactococcus lactis subsp. cremoris MG1363 4798250 YP_001032108.1 CDS llmg_0772 NC_009004.1 760889 762898 D hypothetical protein 760889..762898 Lactococcus lactis subsp. cremoris MG1363 4796839 YP_001032109.1 CDS pepQ NC_009004.1 763002 764090 R Xaa-Pro dipeptidase; High confidence in function and specificity; proline dipeptidase complement(763002..764090) Lactococcus lactis subsp. cremoris MG1363 4798484 YP_001032110.1 CDS ccpA NC_009004.1 764304 765302 D High confidence in function and specificity; catabolite control protein A 764304..765302 Lactococcus lactis subsp. cremoris MG1363 4798133 YP_001032111.1 CDS trxB2 NC_009004.1 765436 766401 D High confidence in function and specificity; TrxB2 protein 765436..766401 Lactococcus lactis subsp. cremoris MG1363 4798588 YP_001032112.1 CDS llmg_0777 NC_009004.1 766699 767259 D Similar to Colicin V production protein; Conserved hypothetical protein; hypothetical protein 766699..767259 Lactococcus lactis subsp. cremoris MG1363 4798634 YP_001032113.1 CDS mutS NC_009004.1 767303 769633 D mutS2: MutS2 family protein; High confidence in function and specificity; DNA mismatch repair protein mutS 767303..769633 Lactococcus lactis subsp. cremoris MG1363 4798252 YP_001032114.1 CDS trxA NC_009004.1 769730 770044 D Contains thioredoxin domain 2; High confidence in function and specificity; thioredoxin 769730..770044 Lactococcus lactis subsp. cremoris MG1363 4798742 YP_001032115.1 CDS llmg_0781 NC_009004.1 770287 770490 D hypothetical protein 770287..770490 Lactococcus lactis subsp. cremoris MG1363 4797145 YP_001032116.1 CDS aroD NC_009004.1 770763 771452 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 770763..771452 Lactococcus lactis subsp. cremoris MG1363 4798537 YP_001032117.1 CDS purB NC_009004.1 771667 772962 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 771667..772962 Lactococcus lactis subsp. cremoris MG1363 4798929 YP_001032118.1 CDS rbsR NC_009004.1 773097 774080 D High confidence in function and specificity; ribose operon repressor 773097..774080 Lactococcus lactis subsp. cremoris MG1363 4798522 YP_001032119.1 CDS rbsK NC_009004.1 774091 775011 D High confidence in function and specificity; ribokinase 774091..775011 Lactococcus lactis subsp. cremoris MG1363 4796582 YP_001032120.1 CDS rbsD NC_009004.1 775016 775414 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 775016..775414 Lactococcus lactis subsp. cremoris MG1363 4796656 YP_001032121.1 CDS rbsD NC_009004.1 775445 776911 D RbsD / FucU transport protein family; High confidence in function and specificity; ribose ABC transporter permease RbsD 775445..776911 Lactococcus lactis subsp. cremoris MG1363 4796781 YP_001032122.1 CDS rbsC NC_009004.1 776908 777855 D High confidence in function and specificity; ribose transport system permease RbsC 776908..777855 Lactococcus lactis subsp. cremoris MG1363 4796761 YP_001032123.1 CDS rbsB NC_009004.1 777867 778841 D High confidence in function and specificity; ribose ABC transporter substrate binding protein RbsB 777867..778841 Lactococcus lactis subsp. cremoris MG1363 4796819 YP_001032124.1 CDS ps301 NC_009004.1 779032 780165 R PF00589: Phage integrase; High confidence in function and specificity; integrase complement(779032..780165) Lactococcus lactis subsp. cremoris MG1363 4799133 YP_001032125.1 CDS ps302 NC_009004.1 780291 780917 R hypothetical protein complement(780291..780917) Lactococcus lactis subsp. cremoris MG1363 4797812 YP_001032126.1 CDS ps303 NC_009004.1 780974 781411 R PF06114: Protein of unknown function DUF955; hypothetical protein complement(780974..781411) Lactococcus lactis subsp. cremoris MG1363 4798001 YP_001032127.1 CDS ps304 NC_009004.1 781408 781905 R repressor, IPR010982: Lambda repressor-like, DNA- binding, PF01381: Helix-turn-helix; High confidence in function and specificity; hypothetical protein complement(781408..781905) Lactococcus lactis subsp. cremoris MG1363 4797181 YP_001032128.1 CDS ps305 NC_009004.1 782307 783116 R hypothetical protein complement(782307..783116) Lactococcus lactis subsp. cremoris MG1363 4797179 YP_001032129.1 CDS ps306 NC_009004.1 783270 783521 D IPR010982: Lambda repressor-like, DNA-binding; hypothetical protein 783270..783521 Lactococcus lactis subsp. cremoris MG1363 4797172 YP_001032130.1 CDS ps307 NC_009004.1 783536 783754 D hypothetical protein 783536..783754 Lactococcus lactis subsp. cremoris MG1363 4797171 YP_001032131.1 CDS ps308 NC_009004.1 783764 784477 D antirepressor; hypothetical protein 783764..784477 Lactococcus lactis subsp. cremoris MG1363 4797169 YP_001032132.1 CDS ps309 NC_009004.1 784490 784726 D hypothetical protein 784490..784726 Lactococcus lactis subsp. cremoris MG1363 4797158 YP_001032133.1 CDS ps310 NC_009004.1 784880 785113 D hypothetical protein 784880..785113 Lactococcus lactis subsp. cremoris MG1363 4798285 YP_001032134.1 CDS ps311 NC_009004.1 785068 785346 R hypothetical protein complement(785068..785346) Lactococcus lactis subsp. cremoris MG1363 4798310 YP_001032135.1 CDS ps312 NC_009004.1 785452 785700 D hypothetical protein 785452..785700 Lactococcus lactis subsp. cremoris MG1363 4798308 YP_001032136.1 CDS ps313 NC_009004.1 785697 785873 D PF04761: Lactococcus bacteriophage transcription regulator; transcriptional regulator 785697..785873 Lactococcus lactis subsp. cremoris MG1363 4798298 YP_001032137.1 CDS ps314 NC_009004.1 785978 786496 D PF07211: Protein of unknown function DUF1417; hypothetical protein 785978..786496 Lactococcus lactis subsp. cremoris MG1363 4797319 YP_001032138.1 CDS ps315 NC_009004.1 786505 787224 D TIGR01618: phage nucleotide-binding protein; Conserved hypothetical protein; hypothetical protein 786505..787224 Lactococcus lactis subsp. cremoris MG1363 4797293 YP_001032139.1 CDS ps316 NC_009004.1 787224 787727 D ssDNA binding protein; hypothetical protein 787224..787727 Lactococcus lactis subsp. cremoris MG1363 4797289 YP_001032140.1 CDS ps317 NC_009004.1 787863 788702 D PF06926: replisome organiser protein C- terminus; Family membership; replisome organizer protein 787863..788702 Lactococcus lactis subsp. cremoris MG1363 4797266 YP_001032141.1 CDS ps318 NC_009004.1 788712 789596 D DnaC protein; hypothetical protein 788712..789596 Lactococcus lactis subsp. cremoris MG1363 4797249 YP_001032142.1 CDS ps319 NC_009004.1 789593 789757 D hypothetical protein 789593..789757 Lactococcus lactis subsp. cremoris MG1363 4797246 YP_001032143.1 CDS ps320 NC_009004.1 789681 790166 D holliday junction resolvase, PF05866: Endodeoxyribonuclease RusA; High confidence in function and specificity; hypothetical protein 789681..790166 Lactococcus lactis subsp. cremoris MG1363 4798514 YP_001032144.1 CDS ps321 NC_009004.1 790167 790406 D PF06275: Protein of unknown function DUF1031; hypothetical protein 790167..790406 Lactococcus lactis subsp. cremoris MG1363 4798423 YP_001032145.1 CDS ps322 NC_009004.1 790512 791036 D hypothetical protein 790512..791036 Lactococcus lactis subsp. cremoris MG1363 4798424 YP_001032146.1 CDS ps323 NC_009004.1 791050 791256 D PF06563: Protein of unknown function DUF1125; hypothetical protein 791050..791256 Lactococcus lactis subsp. cremoris MG1363 4797954 YP_001032147.1 CDS ps324 NC_009004.1 791249 791797 D PF07852: Protein of unknown function DUF1642; hypothetical protein 791249..791797 Lactococcus lactis subsp. cremoris MG1363 4797187 YP_001032148.1 CDS ps325 NC_009004.1 791794 792213 D PF00692: dUTPase, TIGR00576: deoxyuridine 5'- triphosphate nucleotidohydrolase (dut); High confidence in function and specificity; deoxyuridine 5'-triphosphate nucleotidohydrolase 791794..792213 Lactococcus lactis subsp. cremoris MG1363 4797947 YP_001032149.1 CDS ps326 NC_009004.1 792216 792554 D hypothetical protein 792216..792554 Lactococcus lactis subsp. cremoris MG1363 4797935 YP_001032150.1 CDS ps327 NC_009004.1 792551 793231 D hypothetical protein 792551..793231 Lactococcus lactis subsp. cremoris MG1363 4797895 YP_001032151.1 CDS ps328 NC_009004.1 793311 793529 D hypothetical protein 793311..793529 Lactococcus lactis subsp. cremoris MG1363 4797887 YP_001032152.1 CDS ps329 NC_009004.1 793526 793699 D hypothetical protein 793526..793699 Lactococcus lactis subsp. cremoris MG1363 4797866 YP_001032153.1 CDS ps330 NC_009004.1 794054 794479 D PF05263: Protein of unknown function DUF722; hypothetical protein 794054..794479 Lactococcus lactis subsp. cremoris MG1363 4797862 YP_001032154.1 CDS tnp712 NC_009004.1 794656 795879 D PF00665: Integrase core domain; Conserved hypothetical protein; transposase for insertion sequence element IS712D 794656..795879 Lactococcus lactis subsp. cremoris MG1363 4797859 YP_001032155.1 CDS llmg_0823 NC_009004.1 795891 796649 D PF01695: IstB-like ATP-binding protein; Conserved hypothetical protein; transposase helper protein for IS712D 795891..796649 Lactococcus lactis subsp. cremoris MG1363 4796975 YP_001032156.1 CDS ps333 NC_009004.1 797030 797542 D PF03592: Terminase small subunit; High confidence in function and specificity; terminase small subunit 797030..797542 Lactococcus lactis subsp. cremoris MG1363 4797306 YP_001032157.1 CDS ps334 NC_009004.1 797532 798767 D TIGR01547: phage terminase, large subunit, PBSX family; terminase large subunit 797532..798767 Lactococcus lactis subsp. cremoris MG1363 4797856 YP_001032158.1 CDS ps335 NC_009004.1 798777 800285 D PF05133: Phage portal protein, SPP1 Gp6-like, TIGR01538: phage portal protein, SPP1 family; Conserved hypothetical protein; portal protein 798777..800285 Lactococcus lactis subsp. cremoris MG1363 4797851 YP_001032159.1 CDS ps336 NC_009004.1 800675 800962 D PF04327: Protein of unknown function DUF464; Specificity unclear; hypothetical protein 800675..800962 Lactococcus lactis subsp. cremoris MG1363 4799018 YP_001032160.1 CDS ps337 NC_009004.1 800968 802065 D TIGR01641 : phage head morphogenesis protein, SPP1 gp7 family; hypothetical protein 800968..802065 Lactococcus lactis subsp. cremoris MG1363 4798477 YP_001032161.1 CDS ps338 NC_009004.1 802098 802628 D hypothetical protein 802098..802628 Lactococcus lactis subsp. cremoris MG1363 4798550 YP_001032162.1 CDS ps339 NC_009004.1 802688 802846 D hypothetical protein 802688..802846 Lactococcus lactis subsp. cremoris MG1363 4799045 YP_001032163.1 CDS ps340 NC_009004.1 802843 803115 R hypothetical protein complement(802843..803115) Lactococcus lactis subsp. cremoris MG1363 4796801 YP_001032164.1 CDS ps341 NC_009004.1 803292 803918 D hypothetical protein 803292..803918 Lactococcus lactis subsp. cremoris MG1363 4799012 YP_001032165.1 CDS ps342 NC_009004.1 803930 805048 D major head protein 803930..805048 Lactococcus lactis subsp. cremoris MG1363 4798568 YP_001032166.1 CDS ps343 NC_009004.1 805069 805401 D hypothetical protein 805069..805401 Lactococcus lactis subsp. cremoris MG1363 4799066 YP_001032167.1 CDS ps344 NC_009004.1 805382 805735 D hypothetical protein 805382..805735 Lactococcus lactis subsp. cremoris MG1363 4799059 YP_001032168.1 CDS ps345 NC_009004.1 805719 806267 D hypothetical protein 805719..806267 Lactococcus lactis subsp. cremoris MG1363 4798829 YP_001032169.1 CDS ps346 NC_009004.1 806267 806629 D hypothetical protein 806267..806629 Lactococcus lactis subsp. cremoris MG1363 4798896 YP_001032170.1 CDS ps347 NC_009004.1 806642 807055 D Conserved hypothetical protein; major tail protein 806642..807055 Lactococcus lactis subsp. cremoris MG1363 4798905 YP_001032171.1 CDS ps348 NC_009004.1 807132 807542 D hypothetical protein 807132..807542 Lactococcus lactis subsp. cremoris MG1363 4798913 YP_001032172.1 CDS ps349 NC_009004.1 807629 807937 D hypothetical protein 807629..807937 Lactococcus lactis subsp. cremoris MG1363 4798920 YP_001032173.1 CDS ps350 NC_009004.1 807969 812669 D minor tail protein; hypothetical protein 807969..812669 Lactococcus lactis subsp. cremoris MG1363 4798124 YP_001032174.1 CDS ps351 NC_009004.1 812681 813046 D hypothetical protein 812681..813046 Lactococcus lactis subsp. cremoris MG1363 4798277 YP_001032175.1 CDS ps352 NC_009004.1 813058 815595 D hypothetical protein 813058..815595 Lactococcus lactis subsp. cremoris MG1363 4798870 YP_001032176.1 CDS ps353 NC_009004.1 815729 817222 D hypothetical protein 815729..817222 Lactococcus lactis subsp. cremoris MG1363 4798400 YP_001032177.1 CDS ps354 NC_009004.1 817303 817608 D hypothetical protein 817303..817608 Lactococcus lactis subsp. cremoris MG1363 4797569 YP_001032178.1 CDS ps355 NC_009004.1 817595 817819 D holin 817595..817819 Lactococcus lactis subsp. cremoris MG1363 4797440 YP_001032179.1 CDS ps356 NC_009004.1 817816 819105 D PF01183: Glycosyl hydrolases family 25; High confidence in function and specificity; endolysin 817816..819105 Lactococcus lactis subsp. cremoris MG1363 4798697 YP_001032180.1 CDS ps357 NC_009004.1 819287 820246 D PF07751: Abi-like protein; hypothetical protein 819287..820246 Lactococcus lactis subsp. cremoris MG1363 4798717 YP_001032181.1 CDS ps358 NC_009004.1 820437 820673 D hypothetical protein 820437..820673 Lactococcus lactis subsp. cremoris MG1363 4798701 YP_001032182.1 CDS llmg_0854 NC_009004.1 821178 821600 D hypothetical protein 821178..821600 Lactococcus lactis subsp. cremoris MG1363 4797490 YP_001032183.1 CDS llmg_0855 NC_009004.1 821605 821910 D hypothetical protein 821605..821910 Lactococcus lactis subsp. cremoris MG1363 4798529 YP_001032184.1 CDS llmg_0856 NC_009004.1 822270 823712 D multidrug transporter PF07690: Major Facilitator Superfamily; hypothetical protein 822270..823712 Lactococcus lactis subsp. cremoris MG1363 4798367 YP_001032185.1 CDS kdgR NC_009004.1 823766 824446 R Bacterial regulatory proteins, gntR family; High confidence in function and specificity; GntR family transcriptional regulator complement(823766..824446) Lactococcus lactis subsp. cremoris MG1363 4798361 YP_001032186.1 CDS uxuB NC_009004.1 824842 826476 D High confidence in function and specificity; fructuronate reductase 824842..826476 Lactococcus lactis subsp. cremoris MG1363 4797622 YP_001032187.1 CDS uxuA NC_009004.1 826582 827658 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 826582..827658 Lactococcus lactis subsp. cremoris MG1363 4797290 YP_001032188.1 CDS uxuT NC_009004.1 827843 829369 D Major facilitator superfamily MFS_1; High confidence in function and specificity; Na-galactoside symporter 827843..829369 Lactococcus lactis subsp. cremoris MG1363 4797304 YP_001032189.1 CDS llmg_0861 NC_009004.1 829429 830310 D Galactose mutarotase-like; Function unclear; hypothetical protein 829429..830310 Lactococcus lactis subsp. cremoris MG1363 4798515 YP_001032190.1 CDS uxaC NC_009004.1 830323 831741 D catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 830323..831741 Lactococcus lactis subsp. cremoris MG1363 4798859 YP_001032191.1 CDS kdgA NC_009004.1 832691 833332 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 832691..833332 Lactococcus lactis subsp. cremoris MG1363 4797709 YP_001032192.1 CDS llmg_0865 NC_009004.1 833507 835447 D Family membership; BglG family transcriptional antiterminator 833507..835447 Lactococcus lactis subsp. cremoris MG1363 4797627 YP_001032193.1 CDS llmg_0866 NC_009004.1 835449 835748 D High confidence in function and specificity; pentitol PTS system transporter subunit IIB 835449..835748 Lactococcus lactis subsp. cremoris MG1363 4798857 YP_001032194.1 CDS ulaA NC_009004.1 835801 837201 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 835801..837201 Lactococcus lactis subsp. cremoris MG1363 4798849 YP_001032195.1 CDS tkt NC_009004.1 837369 839345 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 837369..839345 Lactococcus lactis subsp. cremoris MG1363 4798845 YP_001032196.1 CDS llmg_0869 NC_009004.1 839513 839764 D hypothetical protein 839513..839764 Lactococcus lactis subsp. cremoris MG1363 4797080 YP_001032197.1 CDS llmg_0870 NC_009004.1 840113 840976 D Similar to glycerol uptake facilitator glpF; Function unclear; transporter 840113..840976 Lactococcus lactis subsp. cremoris MG1363 4798840 YP_001032198.1 CDS asd NC_009004.1 841072 842157 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 841072..842157 Lactococcus lactis subsp. cremoris MG1363 4798837 YP_001032199.1 CDS llmg_0872 NC_009004.1 842158 842625 D contains NUDIX domain; Family membership; (di)nucleoside polyphosphate hydrolase 842158..842625 Lactococcus lactis subsp. cremoris MG1363 4797224 YP_001032200.1 CDS llmg_0873 NC_009004.1 842612 843067 D contains NUDIX domain; High confidence in function and specificity; (di)nucleoside polyphosphate hydrolase 842612..843067 Lactococcus lactis subsp. cremoris MG1363 4798825 YP_001032201.1 CDS dapA NC_009004.1 843396 844289 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 843396..844289 Lactococcus lactis subsp. cremoris MG1363 4798822 YP_001032202.1 CDS llmg_0875 NC_009004.1 844329 845000 R MgtC/SapB family protein; Family membership; cation-transporting ATPase complement(844329..845000) Lactococcus lactis subsp. cremoris MG1363 4798874 YP_001032203.1 CDS llmg_0876 NC_009004.1 845351 847063 D Family membership; metallo-beta-lactamase superfamily protein 845351..847063 Lactococcus lactis subsp. cremoris MG1363 4798814 YP_001032204.1 CDS llmg_0877 NC_009004.1 847112 850345 D Similar to Immunoglobulin A1 protease precursor; Conserved hypothetical protein; hypothetical protein 847112..850345 Lactococcus lactis subsp. cremoris MG1363 4798810 YP_001032205.1 CDS ffh NC_009004.1 850424 851980 D Signal recognition particle 54 kDa protein 2 (SRP54); High confidence in function and specificity; signal recognition particle protein 850424..851980 Lactococcus lactis subsp. cremoris MG1363 4798800 YP_001032206.1 CDS speG NC_009004.1 852014 852556 R GCN5-related N-acetyltransferase; High confidence in function and specificity; spermidine acetyltransferase complement(852014..852556) Lactococcus lactis subsp. cremoris MG1363 4797138 YP_001032207.1 CDS llmg_0880 NC_009004.1 852641 853213 R High confidence in function and specificity; oxidoreductase complement(852641..853213) Lactococcus lactis subsp. cremoris MG1363 4797342 YP_001032208.1 CDS azlC NC_009004.1 853408 854115 D Conserved hypothetical protein; branched chain amino acid ABC transporter 853408..854115 Lactococcus lactis subsp. cremoris MG1363 4798797 YP_001032209.1 CDS llmg_0882 NC_009004.1 854102 854428 D Protein of unknown function DUF931; Conserved hypothetical protein; hypothetical protein 854102..854428 Lactococcus lactis subsp. cremoris MG1363 4798632 YP_001032210.1 CDS llmg_0883 NC_009004.1 854545 854787 D hypothetical protein 854545..854787 Lactococcus lactis subsp. cremoris MG1363 4798791 YP_001032211.1 CDS llmg_0884 NC_009004.1 854784 856241 D Protein of unknown function DUF438; hypothetical protein 854784..856241 Lactococcus lactis subsp. cremoris MG1363 4798786 YP_001032212.1 CDS proB NC_009004.1 856402 857208 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 856402..857208 Lactococcus lactis subsp. cremoris MG1363 4798779 YP_001032213.1 CDS proA NC_009004.1 857316 858560 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 857316..858560 Lactococcus lactis subsp. cremoris MG1363 4797068 YP_001032214.1 CDS llmg_0887 NC_009004.1 858798 859715 R CDF: cation diffusion facilitator family transporter; Specificity unclear; cation transport protein complement(858798..859715) Lactococcus lactis subsp. cremoris MG1363 4797117 YP_001032215.1 CDS rarA NC_009004.1 859705 860004 R Function unclear; ArsR family transcriptional regulator complement(859705..860004) Lactococcus lactis subsp. cremoris MG1363 4798773 YP_001032216.1 CDS llmg_0889 NC_009004.1 860109 860807 D hypothetical protein 860109..860807 Lactococcus lactis subsp. cremoris MG1363 4798628 YP_001032217.1 CDS pyrR NC_009004.1 861083 861604 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 861083..861604 Lactococcus lactis subsp. cremoris MG1363 4799051 YP_001032218.1 CDS pyrP NC_009004.1 861704 862996 D High confidence in function and specificity; uracil permease 861704..862996 Lactococcus lactis subsp. cremoris MG1363 4798922 YP_001032219.1 CDS pyrB NC_009004.1 863245 864177 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 863245..864177 Lactococcus lactis subsp. cremoris MG1363 4798862 YP_001032220.1 CDS carA NC_009004.1 864265 865338 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 864265..865338 Lactococcus lactis subsp. cremoris MG1363 4798479 YP_001032221.1 CDS llmg_0895 NC_009004.1 865499 865771 R hypothetical protein complement(865499..865771) Lactococcus lactis subsp. cremoris MG1363 4797643 YP_001032222.1 CDS llmg_0896 NC_009004.1 865869 866270 R phage gene; hypothetical protein complement(865869..866270) Lactococcus lactis subsp. cremoris MG1363 4798464 YP_001032223.1 CDS llmg_0897 NC_009004.1 866339 867028 R Protein of unknown function DUF1535; Conserved hypothetical protein; hypothetical protein complement(866339..867028) Lactococcus lactis subsp. cremoris MG1363 4798467 YP_001032224.1 CDS llmg_0898 NC_009004.1 867411 867572 D hypothetical protein 867411..867572 Lactococcus lactis subsp. cremoris MG1363 4797602 YP_001032225.1 CDS llmg_0899 NC_009004.1 867654 867956 D hypothetical protein 867654..867956 Lactococcus lactis subsp. cremoris MG1363 4797710 YP_001032226.1 CDS ymbI NC_009004.1 868074 868334 D helper protein for IS981; hypothetical protein 868074..868334 Lactococcus lactis subsp. cremoris MG1363 4798595 YP_001032227.1 CDS tnp981 NC_009004.1 868346 869185 D Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981H 868346..869185 Lactococcus lactis subsp. cremoris MG1363 4798328 YP_001032228.1 CDS arsC NC_009004.1 869928 870332 D Similar to low molecular weight phosphotyrosine protein phosphatases; High confidence in function and specificity; arsenate reductase 869928..870332 Lactococcus lactis subsp. cremoris MG1363 4796956 YP_001032229.1 CDS llmg_0903 NC_009004.1 870444 871280 D Family membership; serine/threonine phosphatase 870444..871280 Lactococcus lactis subsp. cremoris MG1363 4798256 YP_001032230.1 CDS llmg_0904 NC_009004.1 871373 872284 D contains CHAP domain; Family membership; hypothetical protein 871373..872284 Lactococcus lactis subsp. cremoris MG1363 4798606 YP_001032231.1 CDS llmg_0905 NC_009004.1 872521 872883 D hypothetical protein 872521..872883 Lactococcus lactis subsp. cremoris MG1363 4798600 YP_001032232.1 CDS rpmE2 NC_009004.1 873207 873452 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 873207..873452 Lactococcus lactis subsp. cremoris MG1363 4798758 YP_001032233.1 CDS llmg_0907 NC_009004.1 873585 874115 D Predicted metal-binding, possibly nucleic acid- binding protein, Protein of unknown function DUF177; Conserved hypothetical protein; ORF2; hypothetical protein 873585..874115 Lactococcus lactis subsp. cremoris MG1363 4798245 YP_001032234.1 CDS llrA NC_009004.1 874271 874963 D Contains response regulator receiver domain; High confidence in function and specificity; two-component system regulator llrA 874271..874963 Lactococcus lactis subsp. cremoris MG1363 4798770 YP_001032235.1 CDS kinA NC_009004.1 874950 876440 D High confidence in function and specificity; sensor protein kinase kinA 874950..876440 Lactococcus lactis subsp. cremoris MG1363 4796692 YP_001032236.1 CDS amtB NC_009004.1 876626 877867 D High confidence in function and specificity; ammonium transporter 876626..877867 Lactococcus lactis subsp. cremoris MG1363 4796642 YP_001032237.1 CDS glnB NC_009004.1 877949 878290 D High confidence in function and specificity; nitrogen regulatory protein P-II 877949..878290 Lactococcus lactis subsp. cremoris MG1363 4799025 YP_001032238.1 CDS murD NC_009004.1 878459 879808 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 878459..879808 Lactococcus lactis subsp. cremoris MG1363 4797892 YP_001032239.1 CDS murG NC_009004.1 880051 881124 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 880051..881124 Lactococcus lactis subsp. cremoris MG1363 4797430 YP_001032240.1 CDS ftsQ NC_009004.1 881125 882291 D High confidence in function and specificity; cell division protein FtsQ 881125..882291 Lactococcus lactis subsp. cremoris MG1363 4796917 YP_001032241.1 CDS obgE NC_009004.1 882441 883754 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 882441..883754 Lactococcus lactis subsp. cremoris MG1363 4798413 YP_001032242.1 CDS llmg_0916 NC_009004.1 883782 883952 D hypothetical protein 883782..883952 Lactococcus lactis subsp. cremoris MG1363 4797452 YP_001032243.1 CDS llmg_0917 NC_009004.1 884001 884603 R hypothetical protein complement(884001..884603) Lactococcus lactis subsp. cremoris MG1363 4797537 YP_001032244.1 CDS llmg_0918 NC_009004.1 884971 885270 D hypothetical protein 884971..885270 Lactococcus lactis subsp. cremoris MG1363 4797558 YP_001032245.1 CDS llmg_0920 NC_009004.1 886205 886996 D Conserved hypothetical protein; hypothetical protein 886205..886996 Lactococcus lactis subsp. cremoris MG1363 4797515 YP_001032246.1 CDS llmg_0921 NC_009004.1 887034 887792 D Conserved hypothetical protein; hypothetical protein 887034..887792 Lactococcus lactis subsp. cremoris MG1363 4798347 YP_001032247.1 CDS llmg_0922 NC_009004.1 887830 888585 D Conserved hypothetical protein; hypothetical protein 887830..888585 Lactococcus lactis subsp. cremoris MG1363 4796853 YP_001032248.1 CDS llmg_0924 NC_009004.1 893584 894645 D Bacterial protein of unknown function DUF916, Similar to cell wall surface anchor family protein; hypothetical protein 893584..894645 Lactococcus lactis subsp. cremoris MG1363 4797510 YP_001032249.1 CDS llmg_0925 NC_009004.1 894809 895120 D Lambda repressor-like, DNA-binding; Family membership; transcriptional regulator 894809..895120 Lactococcus lactis subsp. cremoris MG1363 4798817 YP_001032250.1 CDS queA NC_009004.1 895195 896235 R Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase complement(895195..896235) Lactococcus lactis subsp. cremoris MG1363 4798830 YP_001032251.1 CDS llmg_0927 NC_009004.1 896558 897529 D Esterase/lipase/thioesterase, conserved secreted hypothetical protein; possible alpha/beta hydrolase; Family membership; extracellular hydrolase 896558..897529 Lactococcus lactis subsp. cremoris MG1363 4799055 YP_001032252.1 CDS nagB NC_009004.1 897703 898410 D Glucosamine-6-phosphate deaminase; High confidence in function and specificity; glucosamine-6-phosphate isomerase 897703..898410 Lactococcus lactis subsp. cremoris MG1363 4797686 YP_001032253.1 CDS hmcM NC_009004.1 898471 899625 R High confidence in function and specificity; hydroxymethylglutaryl-CoA synthase complement(898471..899625) Lactococcus lactis subsp. cremoris MG1363 4797025 YP_001032254.1 CDS thiL NC_009004.1 899909 901069 D High confidence in function and specificity; ThiL protein 899909..901069 Lactococcus lactis subsp. cremoris MG1363 4796672 YP_001032255.1 CDS mvaA NC_009004.1 901117 902349 D High confidence in function and specificity; MvaA protein 901117..902349 Lactococcus lactis subsp. cremoris MG1363 4797030 YP_001032256.1 CDS rpsP NC_009004.1 902434 902706 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 902434..902706 Lactococcus lactis subsp. cremoris MG1363 4798236 YP_001032257.1 CDS llmg_0933 NC_009004.1 902802 903041 D contains KH domain (SSF54814); RNA binding protein 902802..903041 Lactococcus lactis subsp. cremoris MG1363 4798407 YP_001032258.1 CDS hemH NC_009004.1 903241 904197 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 903241..904197 Lactococcus lactis subsp. cremoris MG1363 4797693 YP_001032259.1 CDS llmg_0935 NC_009004.1 904223 905068 D contains Alpha/beta hydrolase fold; High confidence in function and specificity; lysophospholipase 904223..905068 Lactococcus lactis subsp. cremoris MG1363 4797551 YP_001032260.1 CDS rimM NC_009004.1 905253 905768 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 905253..905768 Lactococcus lactis subsp. cremoris MG1363 4797724 YP_001032261.1 CDS trmD NC_009004.1 905761 906516 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 905761..906516 Lactococcus lactis subsp. cremoris MG1363 4796933 YP_001032262.1 CDS llmg_0938 NC_009004.1 906642 907034 D Protein of unknown function DUF1149; hypothetical protein 906642..907034 Lactococcus lactis subsp. cremoris MG1363 4798060 YP_001032263.1 CDS llmg_0939 NC_009004.1 907051 907896 D degV family protein; hypothetical protein 907051..907896 Lactococcus lactis subsp. cremoris MG1363 4796661 YP_001032264.1 CDS dapB NC_009004.1 908026 908808 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 908026..908808 Lactococcus lactis subsp. cremoris MG1363 4796683 YP_001032265.1 CDS llmg_0941 NC_009004.1 908874 909416 D GCN5-related N-acetyltransferase; Family membership; acetyltransferase 908874..909416 Lactococcus lactis subsp. cremoris MG1363 4798875 YP_001032266.1 CDS papL NC_009004.1 909616 910824 D catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 909616..910824 Lactococcus lactis subsp. cremoris MG1363 4796595 YP_001032267.1 CDS pepDB NC_009004.1 910947 912371 D High confidence in function and specificity; PepDB protein 910947..912371 Lactococcus lactis subsp. cremoris MG1363 4799071 YP_001032268.1 CDS llmg_0944 NC_009004.1 912482 913000 D Conserved hypothetical protein; hypothetical protein 912482..913000 Lactococcus lactis subsp. cremoris MG1363 4798138 YP_001032269.1 CDS llmg_0945 NC_009004.1 913106 914185 D High confidence in function and specificity; glycerol dehydrogenase 913106..914185 Lactococcus lactis subsp. cremoris MG1363 4796640 YP_001032270.1 CDS cmhR NC_009004.1 914269 915222 D probable metCcysK operon transcriptional activator; Conserved hypothetical protein; HTH-type transcriptional regulator cmhR 914269..915222 Lactococcus lactis subsp. cremoris MG1363 4797150 YP_001032271.1 CDS llmg_0948 NC_009004.1 915370 917241 D Uup: ATPase components of ABC transporters with duplicated ATPase domains; ABC transporter ATP-binding protein 915370..917241 Lactococcus lactis subsp. cremoris MG1363 4797288 YP_001032272.1 CDS llmg_0950 NC_009004.1 917454 918428 D Family membership; oxidoreductase 917454..918428 Lactococcus lactis subsp. cremoris MG1363 4799137 YP_001032273.1 CDS msrA NC_009004.1 918439 918990 R High confidence in function and specificity; MsrA protein complement(918439..918990) Lactococcus lactis subsp. cremoris MG1363 4798561 YP_001032274.1 CDS pyrDA NC_009004.1 919131 920066 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 919131..920066 Lactococcus lactis subsp. cremoris MG1363 4798428 YP_001032275.1 CDS llmg_0953 NC_009004.1 920191 920898 D Protein of unknown function DUF1113; Conserved hypothetical protein; hypothetical protein 920191..920898 Lactococcus lactis subsp. cremoris MG1363 4797712 YP_001032276.1 CDS llmg_0954 NC_009004.1 920958 921227 D hypothetical protein 920958..921227 Lactococcus lactis subsp. cremoris MG1363 4797033 YP_001032277.1 CDS llmg_0955 NC_009004.1 921340 922386 D PF00107.12: Zinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity; alcohol dehydrogenase 921340..922386 Lactococcus lactis subsp. cremoris MG1363 4797113 YP_001032278.1 CDS llmg_0956 NC_009004.1 922479 923477 R Function unclear; LacI family transcriptional regulator complement(922479..923477) Lactococcus lactis subsp. cremoris MG1363 4797000 YP_001032279.1 CDS rpe2 NC_009004.1 923672 924322 D High confidence in function and specificity; ribulose-phosphate 3-epimerase 923672..924322 Lactococcus lactis subsp. cremoris MG1363 4798557 YP_001032280.1 CDS rpiB NC_009004.1 924338 924787 D catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 924338..924787 Lactococcus lactis subsp. cremoris MG1363 4797255 YP_001032281.1 CDS llmg_0959 NC_009004.1 924840 925394 D Specificity unclear; beta-glucosidase 924840..925394 Lactococcus lactis subsp. cremoris MG1363 4798440 YP_001032282.1 CDS llmg_0960 NC_009004.1 925722 926204 D High confidence in function and specificity; beta-glucosidase 925722..926204 Lactococcus lactis subsp. cremoris MG1363 4796942 YP_001032283.1 CDS llmg_0961 NC_009004.1 926354 927256 R ROK_glcA_fam: ROK family protein ( glucokinase); High confidence in function and specificity; sugar kinase complement(926354..927256) Lactococcus lactis subsp. cremoris MG1363 4796911 YP_001032284.1 CDS llmg_0962 NC_009004.1 927365 928525 D Function unclear; AraC family transcriptional regulator 927365..928525 Lactococcus lactis subsp. cremoris MG1363 4797009 YP_001032285.1 CDS llmg_0963 NC_009004.1 928743 930098 D Similar to lactose/cellobiose PTS system IIC components; Specificity unclear; PTS system transporter subunit IIC 928743..930098 Lactococcus lactis subsp. cremoris MG1363 4796722 YP_001032286.1 CDS thyA NC_009004.1 930251 931090 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 930251..931090 Lactococcus lactis subsp. cremoris MG1363 4798358 YP_001032287.1 CDS llmg_0965 NC_009004.1 931532 932221 D hypothetical protein 931532..932221 Lactococcus lactis subsp. cremoris MG1363 4798156 YP_001032288.1 CDS rmaI NC_009004.1 932486 932932 D High confidence in function and specificity; MarR family transcriptional regulator 932486..932932 Lactococcus lactis subsp. cremoris MG1363 4797263 YP_001032289.1 CDS llmg_0967 NC_009004.1 932929 934302 D Major facilitator superfamily; Family membership; permease 932929..934302 Lactococcus lactis subsp. cremoris MG1363 4797269 YP_001032290.1 CDS llmg_0968 NC_009004.1 934523 935275 D High confidence in function and specificity; oxidoreductase 934523..935275 Lactococcus lactis subsp. cremoris MG1363 4798513 YP_001032291.1 CDS llmg_0969 NC_009004.1 935292 935660 D hypothetical protein 935292..935660 Lactococcus lactis subsp. cremoris MG1363 4798006 YP_001032292.1 CDS llmg_0970 NC_009004.1 935694 936008 D Family membership; carboxymuconolactone decarboxylase 935694..936008 Lactococcus lactis subsp. cremoris MG1363 4797313 YP_001032293.1 CDS yphI NC_009004.1 936021 936314 D Contains dimeric alpha-beta barrel region; hypothetical protein 936021..936314 Lactococcus lactis subsp. cremoris MG1363 4797284 YP_001032294.1 CDS llmg_0972 NC_009004.1 936330 936737 D SSF51182: RmlC-like cupin; hypothetical protein 936330..936737 Lactococcus lactis subsp. cremoris MG1363 4797261 YP_001032295.1 CDS purC NC_009004.1 936865 937587 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 936865..937587 Lactococcus lactis subsp. cremoris MG1363 4797955 YP_001032296.1 CDS purS NC_009004.1 937642 937908 D High confidence in function and specificity; phosphoribosylformylglycinamidine synthetase PurS 937642..937908 Lactococcus lactis subsp. cremoris MG1363 4797723 YP_001032297.1 CDS purQ NC_009004.1 937905 938585 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 937905..938585 Lactococcus lactis subsp. cremoris MG1363 4797697 YP_001032298.1 CDS purL NC_009004.1 938802 941021 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 938802..941021 Lactococcus lactis subsp. cremoris MG1363 4797680 YP_001032299.1 CDS purF NC_009004.1 941006 942526 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 941006..942526 Lactococcus lactis subsp. cremoris MG1363 4797656 YP_001032300.1 CDS llmg_0978 NC_009004.1 942840 943262 D hypothetical protein 942840..943262 Lactococcus lactis subsp. cremoris MG1363 4797625 YP_001032301.1 CDS llmg_0979 NC_009004.1 943295 943678 R Conserved hypothetical protein; hypothetical protein complement(943295..943678) Lactococcus lactis subsp. cremoris MG1363 4796739 YP_001032302.1 CDS llmg_0980 NC_009004.1 943687 944595 R Conserved hypothetical protein; hypothetical protein complement(943687..944595) Lactococcus lactis subsp. cremoris MG1363 4796996 YP_001032303.1 CDS llmg_0981 NC_009004.1 944625 944915 D transposase helper protein for IS904; hypothetical protein 944625..944915 Lactococcus lactis subsp. cremoris MG1363 4797102 YP_001032304.1 CDS llmg_0983 NC_009004.1 945825 946406 D Conserved hypothetical protein; hypothetical protein 945825..946406 Lactococcus lactis subsp. cremoris MG1363 4798246 YP_001032305.1 CDS llmg_0984 NC_009004.1 947275 947388 R Similar to first 37 aa of L.lactis IL1403 protein ypgH; hypothetical protein complement(947275..947388) Lactococcus lactis subsp. cremoris MG1363 4797099 YP_001032306.1 CDS llmg_0985 NC_009004.1 947599 948405 D phage protein; Conserved hypothetical protein; hypothetical protein 947599..948405 Lactococcus lactis subsp. cremoris MG1363 4796790 YP_001032307.1 CDS clpB NC_009004.1 948593 951196 D High confidence in function and specificity; ATP-dependent Clp protease 948593..951196 Lactococcus lactis subsp. cremoris MG1363 4798162 YP_001032308.1 CDS purM NC_009004.1 951380 952402 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 951380..952402 Lactococcus lactis subsp. cremoris MG1363 4797128 YP_001032309.1 CDS purN NC_009004.1 952431 952979 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 952431..952979 Lactococcus lactis subsp. cremoris MG1363 4797665 YP_001032310.1 CDS llmg_0989 NC_009004.1 953119 954765 D Family membership; ABC transporter ATP binding and permease 953119..954765 Lactococcus lactis subsp. cremoris MG1363 4797669 YP_001032311.1 CDS llmg_0991 NC_009004.1 956132 956662 R Family membership; AcrR family transcriptional regulator complement(956132..956662) Lactococcus lactis subsp. cremoris MG1363 4797354 YP_001032312.1 CDS llmg_0992 NC_009004.1 956790 957827 D Family membership; nucleoside-diphosphate-sugar epimerase 956790..957827 Lactococcus lactis subsp. cremoris MG1363 4796737 YP_001032313.1 CDS hprT NC_009004.1 957962 958504 D PF00156.12: Phosphoribosyltransferase; High confidence in function and specificity; HprT protein 957962..958504 Lactococcus lactis subsp. cremoris MG1363 4798208 YP_001032314.1 CDS purH NC_009004.1 958681 960237 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 958681..960237 Lactococcus lactis subsp. cremoris MG1363 4797826 YP_001032315.1 CDS llmg_0995 NC_009004.1 960356 961048 D HAD-superfamily subfamily IA hydrolase; Family membership; hydrolase 960356..961048 Lactococcus lactis subsp. cremoris MG1363 4797631 YP_001032316.1 CDS llmg_0996 NC_009004.1 962586 963212 R Family membership; TetR family transcriptional regulator complement(962586..963212) Lactococcus lactis subsp. cremoris MG1363 4797504 YP_001032317.1 CDS purD NC_009004.1 963606 964847 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 963606..964847 Lactococcus lactis subsp. cremoris MG1363 4798158 YP_001032318.1 CDS llmg_0998 NC_009004.1 964919 965611 D TIGR01484: HAD-superfamily hydrolase, subfamily IIB; Family membership; hydrolase 964919..965611 Lactococcus lactis subsp. cremoris MG1363 4798482 YP_001032319.1 CDS purE NC_009004.1 965608 966093 D High confidence in function and specificity; phosphoribosylaminoimidazole carboxylase catalytic subunit 965608..966093 Lactococcus lactis subsp. cremoris MG1363 4796643 YP_001032320.1 CDS purK NC_009004.1 966149 967255 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 966149..967255 Lactococcus lactis subsp. cremoris MG1363 4797613 YP_001032321.1 CDS xylR NC_009004.1 967411 968343 R Conserved hypothetical protein; xylose operon regulator complement(967411..968343) Lactococcus lactis subsp. cremoris MG1363 4797646 YP_001032322.1 CDS xylA NC_009004.1 968454 969149 D High confidence in function and specificity; XylA protein 968454..969149 Lactococcus lactis subsp. cremoris MG1363 4797279 YP_001032323.1 CDS tnp1216 NC_009004.1 969172 969852 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence-like element IS1216 complement(969172..969852) Lactococcus lactis subsp. cremoris MG1363 4797835 YP_001032324.1 CDS llmg_1004 NC_009004.1 969894 970571 D Specificity unclear; beta-glucosidase 969894..970571 Lactococcus lactis subsp. cremoris MG1363 4797081 YP_001032325.1 CDS llmg_1005 NC_009004.1 970613 971482 D ROK_glcA_fam: ROK family protein ( glucokinase); Function unclear; sugar kinase 970613..971482 Lactococcus lactis subsp. cremoris MG1363 4798243 YP_001032326.1 CDS scrK NC_009004.1 971556 972431 D High confidence in function and specificity; fructokinase 971556..972431 Lactococcus lactis subsp. cremoris MG1363 4796921 YP_001032327.1 CDS llmg_1007 NC_009004.1 972415 972561 D hypothetical protein 972415..972561 Lactococcus lactis subsp. cremoris MG1363 4798940 YP_001032328.1 CDS guaA NC_009004.1 972641 974182 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 972641..974182 Lactococcus lactis subsp. cremoris MG1363 4797147 YP_001032329.1 CDS lplB NC_009004.1 974516 975406 D High confidence in function and specificity; sugar ABC transporter substrate binding protein 974516..975406 Lactococcus lactis subsp. cremoris MG1363 4798767 YP_001032330.1 CDS lplC NC_009004.1 975417 976280 D Conserved hypothetical protein; sugar ABC transporter permease 975417..976280 Lactococcus lactis subsp. cremoris MG1363 4796680 YP_001032331.1 CDS lplA NC_009004.1 976352 977548 D High confidence in function and specificity; sugar ABC transporter substrate-binding protein 976352..977548 Lactococcus lactis subsp. cremoris MG1363 4797636 YP_001032332.1 CDS llmg_1012 NC_009004.1 977586 977987 D Specificity unclear; ABC transporter substrate-binding protein 977586..977987 Lactococcus lactis subsp. cremoris MG1363 4796730 YP_001032333.1 CDS llmg_1013 NC_009004.1 978188 978376 D hypothetical protein 978188..978376 Lactococcus lactis subsp. cremoris MG1363 4797107 YP_001032334.1 CDS llmg_1014 NC_009004.1 978828 981218 D Contains Proteinase inhibitor I11 ecotin domain (SSF49772); hypothetical protein 978828..981218 Lactococcus lactis subsp. cremoris MG1363 4796905 YP_001032335.1 CDS ypbC NC_009004.1 981287 982666 R Similar to multi antimicrobial extrusion protein MatE; Conserved hypothetical protein; hypothetical protein complement(981287..982666) Lactococcus lactis subsp. cremoris MG1363 4797013 YP_001032336.1 CDS llmg_1016 NC_009004.1 982765 983670 R Similar to CorA-like Mg2+ transporter proteins; Family membership; cationic transporter complement(982765..983670) Lactococcus lactis subsp. cremoris MG1363 4797438 YP_001032337.1 CDS rmaE NC_009004.1 983847 984266 D High confidence in function and specificity; MarR family transcriptional regulator 983847..984266 Lactococcus lactis subsp. cremoris MG1363 4798191 YP_001032338.1 CDS llmg_1019 NC_009004.1 986437 987216 R Function unclear; oxidoreductase, short-chain dehydrogenase/reductase complement(986437..987216) Lactococcus lactis subsp. cremoris MG1363 4798834 YP_001032339.1 CDS rmeB NC_009004.1 987245 987679 D High confidence in function and specificity; MerR family transcriptional regulator 987245..987679 Lactococcus lactis subsp. cremoris MG1363 4796908 YP_001032340.1 CDS llmg_1021 NC_009004.1 987722 988609 R Protein of unknown function DUF6; Conserved hypothetical protein; hypothetical protein complement(987722..988609) Lactococcus lactis subsp. cremoris MG1363 4796818 YP_001032341.1 CDS fur NC_009004.1 990101 990487 R High confidence in function and specificity; ferric uptake regulation protein complement(990101..990487) Lactococcus lactis subsp. cremoris MG1363 4797355 YP_001032342.1 CDS llmg_1024 NC_009004.1 990614 991303 D Integral membrane protein DUF125; Conserved hypothetical protein; hypothetical protein 990614..991303 Lactococcus lactis subsp. cremoris MG1363 4798603 YP_001032343.1 CDS llmg_1025 NC_009004.1 991303 991983 D Protein of unknown function DUF125; hypothetical protein 991303..991983 Lactococcus lactis subsp. cremoris MG1363 4798417 YP_001032344.1 CDS llmg_1026 NC_009004.1 992059 992802 D Family membership; methyltransferase 992059..992802 Lactococcus lactis subsp. cremoris MG1363 4797123 YP_001032345.1 CDS rmaC NC_009004.1 992912 993331 D Bacterial regulatory protein, MarR family; Family membership; MarR family transcriptional regulator 992912..993331 Lactococcus lactis subsp. cremoris MG1363 4798214 YP_001032346.1 CDS llmg_1028 NC_009004.1 993343 993981 D Family membership; NAD(P)H nitroreductase 993343..993981 Lactococcus lactis subsp. cremoris MG1363 4798633 YP_001032347.1 CDS llmg_1029 NC_009004.1 993996 994355 D Protein of unknown function DUF1304; Conserved hypothetical protein; hypothetical protein 993996..994355 Lactococcus lactis subsp. cremoris MG1363 4798198 YP_001032348.1 CDS trpE NC_009004.1 994809 996179 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 994809..996179 Lactococcus lactis subsp. cremoris MG1363 4798202 YP_001032349.1 CDS trpG NC_009004.1 996231 996812 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 996231..996812 Lactococcus lactis subsp. cremoris MG1363 4798654 YP_001032350.1 CDS trpD NC_009004.1 996817 997824 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 996817..997824 Lactococcus lactis subsp. cremoris MG1363 4796969 YP_001032351.1 CDS llmg_1034 NC_009004.1 998610 998930 D hypothetical protein 998610..998930 Lactococcus lactis subsp. cremoris MG1363 4797100 YP_001032352.1 CDS llmg_1035 NC_009004.1 998956 999135 D hypothetical protein 998956..999135 Lactococcus lactis subsp. cremoris MG1363 4797050 YP_001032353.1 CDS llmg_1037 NC_009004.1 999434 999802 D PF00903.12: Glyoxalase/bleomycin resistance protein/dioxygenase; Specificity unclear; lyase 999434..999802 Lactococcus lactis subsp. cremoris MG1363 4798237 YP_001032354.1 CDS trpC NC_009004.1 999809 1000603 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 999809..1000603 Lactococcus lactis subsp. cremoris MG1363 4798085 YP_001032355.1 CDS trpF NC_009004.1 1000593 1001651 D High confidence in function and specificity; N-(5'-phosphoribosyl)anthranilate isomerase 1000593..1001651 Lactococcus lactis subsp. cremoris MG1363 4797036 YP_001032356.1 CDS llmg_1040 NC_009004.1 1001641 1002213 D acetyltransferase 1001641..1002213 Lactococcus lactis subsp. cremoris MG1363 4796968 YP_001032357.1 CDS trpB NC_009004.1 1002258 1003463 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1002258..1003463 Lactococcus lactis subsp. cremoris MG1363 4798273 YP_001032358.1 CDS trpA NC_009004.1 1003463 1004224 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1003463..1004224 Lactococcus lactis subsp. cremoris MG1363 4796674 YP_001032359.1 CDS bglP NC_009004.1 1006599 1008509 D High confidence in function and specificity; PTS system, beta-glucosides specific enzyme IIABC 1006599..1008509 Lactococcus lactis subsp. cremoris MG1363 4797495 YP_001032360.1 CDS bglH NC_009004.1 1008557 1009993 D High confidence in function and specificity; beta-glucosidase 1008557..1009993 Lactococcus lactis subsp. cremoris MG1363 4797375 YP_001032361.1 CDS busR NC_009004.1 1010159 1010779 D repressor of the osmoprotectant uptake system; High confidence in function and specificity; transcriptional repressor BusR 1010159..1010779 Lactococcus lactis subsp. cremoris MG1363 4796846 YP_001032362.1 CDS busAA NC_009004.1 1010991 1012214 D High confidence in function and specificity; glycine betaine/proline ABC transporter 1010991..1012214 Lactococcus lactis subsp. cremoris MG1363 4797706 YP_001032363.1 CDS busAB NC_009004.1 1012207 1013928 D Conserved hypothetical protein; glycine betaine-binding periplasmic protein 1012207..1013928 Lactococcus lactis subsp. cremoris MG1363 4797696 YP_001032364.1 CDS llmg_1050 NC_009004.1 1014118 1014288 D hypothetical protein 1014118..1014288 Lactococcus lactis subsp. cremoris MG1363 4797700 YP_001032365.1 CDS llmg_1051 NC_009004.1 1014345 1014920 R transcriptional regulator complement(1014345..1014920) Lactococcus lactis subsp. cremoris MG1363 4797567 YP_001032366.1 CDS llmg_1052 NC_009004.1 1015186 1016259 D hypothetical protein 1015186..1016259 Lactococcus lactis subsp. cremoris MG1363 4796866 YP_001032367.1 CDS llmg_1053 NC_009004.1 1016260 1016466 D hypothetical protein 1016260..1016466 Lactococcus lactis subsp. cremoris MG1363 4798052 YP_001032368.1 CDS llmg_1054 NC_009004.1 1016490 1017032 D Similar to ParB-like nucleases; hypothetical protein 1016490..1017032 Lactococcus lactis subsp. cremoris MG1363 4798058 YP_001032369.1 CDS llmg_1055 NC_009004.1 1017062 1017364 D Lambda repressor-like, DNA-binding; Conserved hypothetical protein; transcriptional regulator 1017062..1017364 Lactococcus lactis subsp. cremoris MG1363 4797825 YP_001032370.1 CDS llmg_1056 NC_009004.1 1017646 1018590 D CDF: cation diffusion facilitator family transporter; Conserved hypothetical protein; cation transporter 1017646..1018590 Lactococcus lactis subsp. cremoris MG1363 4797949 YP_001032371.1 CDS llmg_1057 NC_009004.1 1018644 1019075 D Phosphate-starvation-inducible E; Specificity unclear; phosphate-starvation-inducible protein PsiE 1018644..1019075 Lactococcus lactis subsp. cremoris MG1363 4798248 YP_001032372.1 CDS coaA NC_009004.1 1019146 1020066 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(1019146..1020066) Lactococcus lactis subsp. cremoris MG1363 4798460 YP_001032373.1 CDS rsmC NC_009004.1 1020255 1020851 D High confidence in function and specificity; ribosomal RNA small subunit methyltransferase C 1020255..1020851 Lactococcus lactis subsp. cremoris MG1363 4797903 YP_001032374.1 CDS pdp NC_009004.1 1020886 1022178 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 1020886..1022178 Lactococcus lactis subsp. cremoris MG1363 4798397 YP_001032375.1 CDS llmg_1061 NC_009004.1 1022180 1022368 D hypothetical protein 1022180..1022368 Lactococcus lactis subsp. cremoris MG1363 4798125 YP_001032376.1 CDS deoC NC_009004.1 1022381 1023043 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1022381..1023043 Lactococcus lactis subsp. cremoris MG1363 4798303 YP_001032377.1 CDS cdd NC_009004.1 1023030 1023422 D High confidence in function and specificity; Cdd protein 1023030..1023422 Lactococcus lactis subsp. cremoris MG1363 4798883 YP_001032378.1 CDS bmpA NC_009004.1 1023690 1024745 D Conserved hypothetical protein; basic membrane protein A 1023690..1024745 Lactococcus lactis subsp. cremoris MG1363 4796662 YP_001032379.1 CDS rgrB NC_009004.1 1024931 1025638 D High confidence in function and specificity; GntR family transcriptional regulator 1024931..1025638 Lactococcus lactis subsp. cremoris MG1363 4798861 YP_001032380.1 CDS llmg_1066 NC_009004.1 1025646 1026086 R hypothetical protein complement(1025646..1026086) Lactococcus lactis subsp. cremoris MG1363 4797136 YP_001032381.1 CDS kinB NC_009004.1 1026184 1027737 R High confidence in function and specificity; sensor protein kinase kinB complement(1026184..1027737) Lactococcus lactis subsp. cremoris MG1363 4797348 YP_001032382.1 CDS llrB NC_009004.1 1027727 1028437 R Response regulator receiver domain; High confidence in function and specificity; two-component system regulator llrB complement(1027727..1028437) Lactococcus lactis subsp. cremoris MG1363 4796646 YP_001032383.1 CDS llmg_1069 NC_009004.1 1028621 1028956 D PF04297: helix-turn-helix protein, YlxM/p13-like; DNA-binding protein 1028621..1028956 Lactococcus lactis subsp. cremoris MG1363 4796668 YP_001032384.1 CDS llmg_1070 NC_009004.1 1029743 1030273 D Similar to prophage gene p301 from L.lactis IL1403; Conserved hypothetical protein; hypothetical protein 1029743..1030273 Lactococcus lactis subsp. cremoris MG1363 4797308 YP_001032385.1 CDS llmg_1071 NC_009004.1 1030384 1030953 D High confidence in function and specificity; hypothetical protein 1030384..1030953 Lactococcus lactis subsp. cremoris MG1363 4797300 YP_001032386.1 CDS llmg_1072 NC_009004.1 1031842 1032132 D transposase helper protein for IS904; hypothetical protein 1031842..1032132 Lactococcus lactis subsp. cremoris MG1363 4797052 YP_001032387.1 CDS llmg_1073 NC_009004.1 1032228 1032944 D Integrase, catalytic region, 30 aa from the C- terminus are missing, possibly inactive; High confidence in function and specificity; transposase for insertion sequence element IS904E (fragment) 1032228..1032944 Lactococcus lactis subsp. cremoris MG1363 4797256 YP_001032388.1 CDS llmg_1074 NC_009004.1 1032985 1033743 R PF01695: IstB-like ATP-binding protein; Conserved hypothetical protein; transposase helper protein for IS712E complement(1032985..1033743) Lactococcus lactis subsp. cremoris MG1363 4797245 YP_001032389.1 CDS tnp712 NC_009004.1 1033755 1034978 R Integrase, catalytic region; Specificity unclear; transposase for insertion sequence element IS712E complement(1033755..1034978) Lactococcus lactis subsp. cremoris MG1363 4798427 YP_001032390.1 CDS llmg_1076 NC_009004.1 1035285 1035836 R GCN5-related N-acetyltransferase; Family membership; acetyltransferase complement(1035285..1035836) Lactococcus lactis subsp. cremoris MG1363 4797535 YP_001032391.1 CDS llmg_1077 NC_009004.1 1036203 1036625 D Family membership; glyoxalase 1036203..1036625 Lactococcus lactis subsp. cremoris MG1363 4798468 YP_001032392.1 CDS llmg_1078 NC_009004.1 1036771 1037319 D hypothetical protein 1036771..1037319 Lactococcus lactis subsp. cremoris MG1363 4798274 YP_001032393.1 CDS llmg_1079 NC_009004.1 1037518 1037865 R Protein of unknown function DUF1093; hypothetical protein complement(1037518..1037865) Lactococcus lactis subsp. cremoris MG1363 4799020 YP_001032394.1 CDS uspA2 NC_009004.1 1038050 1038478 D Specificity unclear; universal stress protein A2 1038050..1038478 Lactococcus lactis subsp. cremoris MG1363 4796788 YP_001032395.1 CDS llmg_1081 NC_009004.1 1038629 1038982 D Protein of unknown function DUF1304; Conserved hypothetical protein; hypothetical protein 1038629..1038982 Lactococcus lactis subsp. cremoris MG1363 4797343 YP_001032396.1 CDS llmg_1082 NC_009004.1 1039099 1039854 R Conserved hypothetical protein; hypothetical protein complement(1039099..1039854) Lactococcus lactis subsp. cremoris MG1363 4797554 YP_001032397.1 CDS llmg_1083 NC_009004.1 1040025 1040579 R Protein of unknown function DUF1211; Conserved hypothetical protein; hypothetical protein complement(1040025..1040579) Lactococcus lactis subsp. cremoris MG1363 4797591 YP_001032398.1 CDS llmg_1084 NC_009004.1 1040836 1041405 D Conserved hypothetical protein; hypothetical protein 1040836..1041405 Lactococcus lactis subsp. cremoris MG1363 4799107 YP_001032399.1 CDS llmg_1085 NC_009004.1 1041625 1042350 D Protein of unknown function DUF208; hypothetical protein 1041625..1042350 Lactococcus lactis subsp. cremoris MG1363 4799149 YP_001032400.1 CDS llmg_1086 NC_009004.1 1042609 1045242 D Specificity unclear; cation (calcium) transporting ATPase 1042609..1045242 Lactococcus lactis subsp. cremoris MG1363 4799146 YP_001032401.1 CDS acmC NC_009004.1 1045285 1045914 R High confidence in function and specificity; N-acetylglucosaminidase complement(1045285..1045914) Lactococcus lactis subsp. cremoris MG1363 4799143 YP_001032402.1 CDS gpo NC_009004.1 1046138 1046611 D High confidence in function and specificity; gluthatione peroxidase 1046138..1046611 Lactococcus lactis subsp. cremoris MG1363 4798879 YP_001032403.1 CDS carB NC_009004.1 1046961 1050155 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1046961..1050155 Lactococcus lactis subsp. cremoris MG1363 4798610 YP_001032404.1 CDS llmg_1090 NC_009004.1 1050354 1050935 D hypothetical protein 1050354..1050935 Lactococcus lactis subsp. cremoris MG1363 4798932 YP_001032405.1 CDS llmg_1091 NC_009004.1 1051013 1051231 D hypothetical protein 1051013..1051231 Lactococcus lactis subsp. cremoris MG1363 4798928 YP_001032406.1 CDS llmg_1092 NC_009004.1 1051383 1052867 D hypothetical protein 1051383..1052867 Lactococcus lactis subsp. cremoris MG1363 4798624 YP_001032407.1 CDS llmg_1093 NC_009004.1 1052879 1053883 D Bacterial protein of unknown function DUF916; Conserved hypothetical protein; hypothetical protein 1052879..1053883 Lactococcus lactis subsp. cremoris MG1363 4798631 YP_001032408.1 CDS llmg_1094 NC_009004.1 1053915 1054247 D hypothetical protein 1053915..1054247 Lactococcus lactis subsp. cremoris MG1363 4798647 YP_001032409.1 CDS llmg_1095 NC_009004.1 1054301 1055044 D hypothetical protein 1054301..1055044 Lactococcus lactis subsp. cremoris MG1363 4798652 YP_001032410.1 CDS llmg_1096 NC_009004.1 1055122 1056285 D Bacterial protein of unknown function DUF916; hypothetical protein 1055122..1056285 Lactococcus lactis subsp. cremoris MG1363 4798636 YP_001032411.1 CDS glpF2 NC_009004.1 1056343 1057071 R High confidence in function and specificity; glycerol uptake facilitator complement(1056343..1057071) Lactococcus lactis subsp. cremoris MG1363 4798644 YP_001032412.1 CDS glpD NC_009004.1 1057090 1058667 R High confidence in function and specificity; GlpD protein complement(1057090..1058667) Lactococcus lactis subsp. cremoris MG1363 4798028 YP_001032413.1 CDS glpK NC_009004.1 1058720 1060237 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1058720..1060237) Lactococcus lactis subsp. cremoris MG1363 4798474 YP_001032414.1 CDS rluC NC_009004.1 1060537 1061070 D High confidence in function and specificity; ribosomal large subunit pseudouridine synthase 1060537..1061070 Lactococcus lactis subsp. cremoris MG1363 4798342 YP_001032415.1 CDS llmg_1101 NC_009004.1 1061106 1061891 R Protein of unknown function DUF477; Conserved hypothetical protein; hypothetical protein complement(1061106..1061891) Lactococcus lactis subsp. cremoris MG1363 4797579 YP_001032416.1 CDS llmg_1102 NC_009004.1 1061888 1063039 R hypothetical protein complement(1061888..1063039) Lactococcus lactis subsp. cremoris MG1363 4798621 YP_001032417.1 CDS llmg_1103 NC_009004.1 1063253 1064464 R Conserved hypothetical protein; hypothetical protein complement(1063253..1064464) Lactococcus lactis subsp. cremoris MG1363 4796789 YP_001032418.1 CDS llmg_1104 NC_009004.1 1064841 1066205 D Family membership; drug-export protein 1064841..1066205 Lactococcus lactis subsp. cremoris MG1363 4798113 YP_001032419.1 CDS pyrK NC_009004.1 1066455 1067243 D Phthalate dioxygenase reductase; High confidence in function and specificity; dihydroorotate dehydrogenase, electron transfer subunit 1066455..1067243 Lactococcus lactis subsp. cremoris MG1363 4797217 YP_001032420.1 CDS pyrDB NC_009004.1 1067401 1068336 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 1067401..1068336 Lactococcus lactis subsp. cremoris MG1363 4798332 YP_001032421.1 CDS pyrF NC_009004.1 1068466 1069179 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1068466..1069179 Lactococcus lactis subsp. cremoris MG1363 4797639 YP_001032422.1 CDS llmg_1108 NC_009004.1 1069181 1069639 D Conserved hypothetical protein; hypothetical protein 1069181..1069639 Lactococcus lactis subsp. cremoris MG1363 4797373 YP_001032423.1 CDS gidB NC_009004.1 1069648 1070364 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(1069648..1070364) Lactococcus lactis subsp. cremoris MG1363 4798276 YP_001032424.1 CDS ispB NC_009004.1 1070361 1071320 R High confidence in function and specificity; heptaprenyl diphosphate synthase component II complement(1070361..1071320) Lactococcus lactis subsp. cremoris MG1363 4798489 YP_001032425.1 CDS gerCA NC_009004.1 1071311 1071841 R High confidence in function and specificity; heptaprenyl diphosphate synthase component I complement(1071311..1071841) Lactococcus lactis subsp. cremoris MG1363 4797725 YP_001032426.1 CDS llmg_1112 NC_009004.1 1071838 1072245 R Protein of unknown function DUF1312; hypothetical protein complement(1071838..1072245) Lactococcus lactis subsp. cremoris MG1363 4799103 YP_001032427.1 CDS galU NC_009004.1 1072316 1073257 R High confidence in function and specificity; UDP--glucose-1-phosphate uridylyltransferase complement(1072316..1073257) Lactococcus lactis subsp. cremoris MG1363 4798258 YP_001032428.1 CDS gpsA NC_009004.1 1073311 1074339 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(1073311..1074339) Lactococcus lactis subsp. cremoris MG1363 4797670 YP_001032429.1 CDS llmg_1115 NC_009004.1 1074531 1075157 D Similar to Bacillus subtilis xpaC gene, involved in cell morphology; Specificity unclear; XpaC-like protein 1074531..1075157 Lactococcus lactis subsp. cremoris MG1363 4798613 YP_001032430.1 CDS telA1 NC_009004.1 1075298 1076476 D High confidence in function and specificity; toxic anion resistance protein 1075298..1076476 Lactococcus lactis subsp. cremoris MG1363 4797228 YP_001032431.1 CDS nagA NC_009004.1 1076647 1077795 D High confidence in function and specificity; NagA protein 1076647..1077795 Lactococcus lactis subsp. cremoris MG1363 4798217 YP_001032432.1 CDS pfk NC_009004.1 1078182 1079204 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1078182..1079204 Lactococcus lactis subsp. cremoris MG1363 4798168 YP_001032433.1 CDS pyk NC_009004.1 1079292 1080800 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1079292..1080800 Lactococcus lactis subsp. cremoris MG1363 4797791 YP_001032434.1 CDS ldh NC_009004.1 1080918 1081895 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1080918..1081895 Lactococcus lactis subsp. cremoris MG1363 4797727 YP_001032435.1 CDS nupC NC_009004.1 1082012 1082965 R High confidence in function and specificity; purine/cytidine ABC transporter permease complement(1082012..1082965) Lactococcus lactis subsp. cremoris MG1363 4797718 YP_001032436.1 CDS nupB NC_009004.1 1082962 1084056 R High confidence in function and specificity; purine/cytidine ABC transporter permease complement(1082962..1084056) Lactococcus lactis subsp. cremoris MG1363 4797975 YP_001032437.1 CDS nupA NC_009004.1 1084049 1085569 R High confidence in function and specificity; purine/cytidine ABC transporter ATP-binding protein complement(1084049..1085569) Lactococcus lactis subsp. cremoris MG1363 4797583 YP_001032438.1 CDS llmg_1124 NC_009004.1 1085751 1086566 R Similar to rRNA (guanine-N1-)-methyltransferase; Family membership; hypothetical protein complement(1085751..1086566) Lactococcus lactis subsp. cremoris MG1363 4798349 YP_001032439.1 CDS fbpA NC_009004.1 1086608 1088230 R Family membership; fibronectin-binding protein-like protein A complement(1086608..1088230) Lactococcus lactis subsp. cremoris MG1363 4797227 YP_001032440.1 CDS llmg_1126 NC_009004.1 1088535 1088978 D Conserved hypothetical protein; hypothetical protein 1088535..1088978 Lactococcus lactis subsp. cremoris MG1363 4799134 YP_001032441.1 CDS llmg_1127 NC_009004.1 1089321 1093370 D Carboxypeptidase regulatory region; Conserved hypothetical protein; cell wall surface anchor family protein 1089321..1093370 Lactococcus lactis subsp. cremoris MG1363 4797200 YP_001032442.1 CDS llmg_1128 NC_009004.1 1093388 1093633 D Carboxypeptidase regulatory region; hypothetical protein 1093388..1093633 Lactococcus lactis subsp. cremoris MG1363 4798518 YP_001032443.1 CDS llmg_1129 NC_009004.1 1093651 1094226 D Surface protein from Gram-positive cocci, anchor region; cell wall surface anchor family protein 1093651..1094226 Lactococcus lactis subsp. cremoris MG1363 4798269 YP_001032444.1 CDS llmg_1130 NC_009004.1 1094974 1095348 D Arsenate reductase and related, Similar to regulatory protein spx; hypothetical protein 1094974..1095348 Lactococcus lactis subsp. cremoris MG1363 4797792 YP_001032445.1 CDS panE NC_009004.1 1095546 1096484 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 1095546..1096484 Lactococcus lactis subsp. cremoris MG1363 4797211 YP_001032446.1 CDS sbcD NC_009004.1 1096630 1097802 D TIGR00619: nuclease SbcCD, D subunit; High confidence in function and specificity; nuclease SbcCD subunit D 1096630..1097802 Lactococcus lactis subsp. cremoris MG1363 4799072 YP_001032447.1 CDS sbcC NC_009004.1 1097805 1100945 D ATP-dependent dsDNA exonuclease; High confidence in function and specificity; nuclease sbcCD subunit C 1097805..1100945 Lactococcus lactis subsp. cremoris MG1363 4799145 YP_001032448.1 CDS llmg_1134 NC_009004.1 1101195 1101425 D hypothetical protein 1101195..1101425 Lactococcus lactis subsp. cremoris MG1363 4797721 YP_001032449.1 CDS llmg_1135 NC_009004.1 1101504 1101917 R hypothetical protein complement(1101504..1101917) Lactococcus lactis subsp. cremoris MG1363 4798724 YP_001032450.1 CDS mtsB NC_009004.1 1102206 1102919 D PF00005: ABC transporter TIGR01166: cobalt transport protein ATP-binding subunit; High confidence in function and specificity; manganese ABC transporter ATP binding protein 1102206..1102919 Lactococcus lactis subsp. cremoris MG1363 4798268 YP_001032451.1 CDS mtsC NC_009004.1 1102926 1103765 D PF00950: ABC 3 transport family; Conserved hypothetical protein; manganese transport system membrane protein 1102926..1103765 Lactococcus lactis subsp. cremoris MG1363 4797517 YP_001032452.1 CDS mtsA NC_009004.1 1103765 1104712 D PF01297: Periplasmic solute binding protein family; Family membership; manganese ABC transporter substrate binding protein 1103765..1104712 Lactococcus lactis subsp. cremoris MG1363 4797486 YP_001032453.1 CDS llmg_1139 NC_009004.1 1105019 1105885 D hypothetical protein 1105019..1105885 Lactococcus lactis subsp. cremoris MG1363 4797513 YP_001032454.1 CDS llmg_1140 NC_009004.1 1105938 1107194 D hypothetical protein 1105938..1107194 Lactococcus lactis subsp. cremoris MG1363 4797235 YP_001032455.1 CDS llmg_1141 NC_009004.1 1107609 1107932 D contains HTH domain; Conserved hypothetical protein; transcriptional regulator 1107609..1107932 Lactococcus lactis subsp. cremoris MG1363 4797204 YP_001032456.1 CDS tnp905 NC_009004.1 1108260 1109435 R High confidence in function and specificity; transposase for insertion sequence element IS905F complement(1108260..1109435) Lactococcus lactis subsp. cremoris MG1363 4797805 YP_001032457.1 CDS llmg_1143 NC_009004.1 1109730 1110245 D inactivated by IS981, HTH-type transcriptional regulator, PF01381: Helix-turn-helix; hypothetical protein 1109730..1110245 Lactococcus lactis subsp. cremoris MG1363 4798044 YP_001032458.1 CDS tnp981 NC_009004.1 1110256 1111095 R High confidence in function and specificity; transposase for insertion sequence element IS981I complement(1110256..1111095) Lactococcus lactis subsp. cremoris MG1363 4797798 YP_001032459.1 CDS llmg_1145 NC_009004.1 1111107 1111367 R transposase helper protein for IS981; hypothetical protein complement(1111107..1111367) Lactococcus lactis subsp. cremoris MG1363 4797277 YP_001032460.1 CDS llmg_1146 NC_009004.1 1111431 1111781 D inactivated by IS981, HTH-type transcriptional regulator; hypothetical protein 1111431..1111781 Lactococcus lactis subsp. cremoris MG1363 4798263 YP_001032461.1 CDS llmg_1147 NC_009004.1 1113008 1113331 D contains HTH domain; Conserved hypothetical protein; transcriptional regulator 1113008..1113331 Lactococcus lactis subsp. cremoris MG1363 4797234 YP_001032462.1 CDS llmg_1148 NC_009004.1 1113561 1115264 D hypothetical protein 1113561..1115264 Lactococcus lactis subsp. cremoris MG1363 4797770 YP_001032463.1 CDS ocd NC_009004.1 1115457 1116413 D PF02423: Ornithine cyclodeaminase/mu-crystallin family; High confidence in function and specificity; ornithine cyclodeaminase, mu-crystallin-like protein 1115457..1116413 Lactococcus lactis subsp. cremoris MG1363 4797203 YP_001032464.1 CDS llmg_1150 NC_009004.1 1116424 1117206 D phenazine biosynthesis protein, PF02567: Phenazine biosynthesis-like protein, TIGR00654: phenazine biosynthesis protein PhzF family; hypothetical protein 1116424..1117206 Lactococcus lactis subsp. cremoris MG1363 4799095 YP_001032465.1 CDS llmg_1151 NC_009004.1 1117267 1118679 R transcriptional regulator, PF00392: Bacterial regulatory proteins, GntR family; hypothetical protein complement(1117267..1118679) Lactococcus lactis subsp. cremoris MG1363 4797199 YP_001032466.1 CDS llmg_1152 NC_009004.1 1119320 1120990 D PF07523: Bacterial Ig-like domain (group 3); hypothetical protein 1119320..1120990 Lactococcus lactis subsp. cremoris MG1363 4797371 YP_001032467.1 CDS pabA NC_009004.1 1121415 1121996 D PF00117: Glutamine amidotransferase class-I, TIGR00566: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; High confidence in function and specificity; p-aminobenzoate synthetase, component II 1121415..1121996 Lactococcus lactis subsp. cremoris MG1363 4797363 YP_001032468.1 CDS pabB NC_009004.1 1122001 1123887 D PF00425: chorismate binding enzyme, TIGR00553: para- aminobenzoate synthase, component I; High confidence in function and specificity; para-aminobenzoate synthase component I 1122001..1123887 Lactococcus lactis subsp. cremoris MG1363 4799079 YP_001032469.1 CDS llmg_1155 NC_009004.1 1124076 1124447 D potential redox protein; structural similarity to proteins involved in arsenate reduction in the oxydoreduction reaction, Arsenate reductase and related, PF03960: ArsC family; Conserved hypothetical protein; Spx-like protein 1124076..1124447 Lactococcus lactis subsp. cremoris MG1363 4799078 YP_001032470.1 CDS llmg_1156 NC_009004.1 1124506 1124832 D repressor of arsenical resistance, PF06953: Arsenical resistance operon trans-acting repressor ArsD; hypothetical protein 1124506..1124832 Lactococcus lactis subsp. cremoris MG1363 4798447 YP_001032471.1 CDS llmg_1158 NC_009004.1 1124929 1125093 R Pseudogene; hypothetical protein complement(1124929..1125093) Lactococcus lactis subsp. cremoris MG1363 4797964 YP_001032472.1 CDS llmg_1159 NC_009004.1 1125090 1125452 R Pseudogene; hypothetical protein complement(1125090..1125452) Lactococcus lactis subsp. cremoris MG1363 4796849 YP_001032473.1 CDS llmg_1160 NC_009004.1 1125608 1126618 D hypothetical protein 1125608..1126618 Lactococcus lactis subsp. cremoris MG1363 4797577 YP_001032474.1 CDS llmg_1161 NC_009004.1 1126850 1127323 D Pseudogene; Conserved hypothetical protein; sialic acid-specific 9-O-acetylesterase 1126850..1127323 Lactococcus lactis subsp. cremoris MG1363 4799144 YP_001032475.1 CDS llmg_1162 NC_009004.1 1127360 1128718 D Pseudogene; Conserved hypothetical protein; sialic acid-specific 9-O-acetylesterase 1127360..1128718 Lactococcus lactis subsp. cremoris MG1363 4799054 YP_001032476.1 CDS llmg_1163 NC_009004.1 1128720 1130027 D IPR006059: Bacterial extracellular solute-binding protein, family 1; Conserved hypothetical protein; sugar ABC transporter substrate-binding protein 1128720..1130027 Lactococcus lactis subsp. cremoris MG1363 4798935 YP_001032477.1 CDS llmg_1164 NC_009004.1 1130161 1131120 D sugar ABC transporter permease, IPR000515: Binding-protein-dependent transport systems inner membrane component; Conserved hypothetical protein; hypothetical protein 1130161..1131120 Lactococcus lactis subsp. cremoris MG1363 4798931 YP_001032478.1 CDS llmg_1165 NC_009004.1 1131120 1131974 D sugar ABC transporter permease, PF00528: Binding-protein-dependent transport system inner membrane component; Conserved hypothetical protein; hypothetical protein 1131120..1131974 Lactococcus lactis subsp. cremoris MG1363 4798282 YP_001032479.1 CDS llmg_1166 NC_009004.1 1131976 1132872 D pseudogene, IPR008928: Glycoside transferase, six- hairpin; High confidence in function and specificity; endoglucanase 1131976..1132872 Lactococcus lactis subsp. cremoris MG1363 4798270 YP_001032480.1 CDS llmg_1167 NC_009004.1 1132978 1133109 D pseudogene, IPR008928: Glycoside transferase, six- hairpin; Conserved hypothetical protein; endoglucanase 1132978..1133109 Lactococcus lactis subsp. cremoris MG1363 4797239 YP_001032481.1 CDS llmg_1168 NC_009004.1 1133124 1133750 D PF01522: Polysaccharide deacetylase; High confidence in function and specificity; polysaccharide deacetylase 1133124..1133750 Lactococcus lactis subsp. cremoris MG1363 4797236 YP_001032482.1 CDS aguA NC_009004.1 1133781 1135775 D PF07488: Glycosyl hydrolase 67 middle domain, PF07477: Glycosyl hydrolase 67 C-terminus; High confidence in function and specificity; AguA protein 1133781..1135775 Lactococcus lactis subsp. cremoris MG1363 4797216 YP_001032483.1 CDS llmg_1170 NC_009004.1 1135978 1137705 D IPR004843: Metallophosphoesterase; hypothetical protein 1135978..1137705 Lactococcus lactis subsp. cremoris MG1363 4797474 YP_001032484.1 CDS llmg_1171 NC_009004.1 1137774 1139159 R hypothetical protein complement(1137774..1139159) Lactococcus lactis subsp. cremoris MG1363 4797212 YP_001032485.1 CDS rdrB NC_009004.1 1139152 1139913 R PF00455: Bacterial regulatory proteins, deoR family; Conserved hypothetical protein; transcriptional regulator complement(1139152..1139913) Lactococcus lactis subsp. cremoris MG1363 4796858 YP_001032486.1 CDS llmg_1173 NC_009004.1 1140260 1141309 D membrane protein; hypothetical protein 1140260..1141309 Lactococcus lactis subsp. cremoris MG1363 4796740 YP_001032487.1 CDS llmg_1174 NC_009004.1 1141470 1142015 D hypothetical protein 1141470..1142015 Lactococcus lactis subsp. cremoris MG1363 4798406 YP_001032488.1 CDS rbgA NC_009004.1 1142245 1143093 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1142245..1143093 Lactococcus lactis subsp. cremoris MG1363 4797779 YP_001032489.1 CDS rnhB NC_009004.1 1143206 1143979 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1143206..1143979 Lactococcus lactis subsp. cremoris MG1363 4797799 YP_001032490.1 CDS gadR NC_009004.1 1144571 1145401 D activates chloride dependent transcription of gadCB, TIGR01716: Transcriptional activator Rgg/GadR/MutR, C-terminal domain; High confidence in function and specificity; positive regulator GadR 1144571..1145401 Lactococcus lactis subsp. cremoris MG1363 4797311 YP_001032491.1 CDS gadC NC_009004.1 1145542 1147056 D TIGR00910: Glutamate:g-aminobutyrate antiporter, involved in glutamate-dependent acid resistance; High confidence in function and specificity; glutamate/gamma-aminobutyrate antiporter 1145542..1147056 Lactococcus lactis subsp. cremoris MG1363 4798793 YP_001032492.1 CDS gadB NC_009004.1 1147076 1148476 D PF00282: Pyridoxal-dependent decarboxylase conserved domain, TIGR01788: glutamate decarboxylase, involved in glutamate-dependant acid resistance; High confidence in function and specificity; glutamate decarboxylase 1147076..1148476 Lactococcus lactis subsp. cremoris MG1363 4797573 YP_001032493.1 CDS llmg_1180 NC_009004.1 1148551 1149297 R mechanosensitive ion channel, PF00924: Mechanosensitive ion channel; hypothetical protein complement(1148551..1149297) Lactococcus lactis subsp. cremoris MG1363 4798359 YP_001032494.1 CDS ilvE NC_009004.1 1149457 1150479 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1149457..1150479 Lactococcus lactis subsp. cremoris MG1363 4798630 YP_001032495.1 CDS llmg_1182 NC_009004.1 1150512 1151123 R IPR011004: Trimeric LpxA-like; Conserved hypothetical protein; acetyltransferase complement(1150512..1151123) Lactococcus lactis subsp. cremoris MG1363 4797699 YP_001032496.1 CDS gltB NC_009004.1 1151292 1155761 D PF01645: Conserved region in glutamate synthase; High confidence in function and specificity; glutamate synthase, large subunit 1151292..1155761 Lactococcus lactis subsp. cremoris MG1363 4798639 YP_001032497.1 CDS gltD NC_009004.1 1155761 1157200 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 1155761..1157200 Lactococcus lactis subsp. cremoris MG1363 4796775 YP_001032498.1 CDS lysA NC_009004.1 1157315 1158574 D PF00278: Pyridoxal-dependent decarboxylase, C- terminal sheet domain, TIGR01048: diaminopimelate decarboxylase; High confidence in function and specificity; LysA protein 1157315..1158574 Lactococcus lactis subsp. cremoris MG1363 4799015 YP_001032499.1 CDS llmg_1186 NC_009004.1 1158725 1158964 D PF03672: Protein of unknown function UPF0154; hypothetical protein 1158725..1158964 Lactococcus lactis subsp. cremoris MG1363 4797083 YP_001032500.1 CDS murI NC_009004.1 1159140 1159955 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1159140..1159955 Lactococcus lactis subsp. cremoris MG1363 4796830 YP_001032501.1 CDS llmg_1188 NC_009004.1 1159956 1160561 D Ham1-like protein, PF01725: Ham1 family, TIGR00042: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; High confidence in function and specificity; hypothetical protein 1159956..1160561 Lactococcus lactis subsp. cremoris MG1363 4797531 YP_001032502.1 CDS llmg_1189 NC_009004.1 1160600 1161103 D TIGR00040: phosphodiesterase, MJ0936 family, PF00149: Calcineurin-like phosphoesterase; hypothetical protein 1160600..1161103 Lactococcus lactis subsp. cremoris MG1363 4797720 YP_001032503.1 CDS llmg_1190 NC_009004.1 1161134 1161595 D PF00571: 2 CBS domains; hypothetical protein 1161134..1161595 Lactococcus lactis subsp. cremoris MG1363 4797359 YP_001032504.1 CDS xerD NC_009004.1 1161573 1162289 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1161573..1162289 Lactococcus lactis subsp. cremoris MG1363 4797962 YP_001032505.1 CDS scpA NC_009004.1 1162320 1163048 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1162320..1163048 Lactococcus lactis subsp. cremoris MG1363 4797931 YP_001032506.1 CDS scpB NC_009004.1 1163041 1163607 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1163041..1163607 Lactococcus lactis subsp. cremoris MG1363 4799068 YP_001032507.1 CDS rluB NC_009004.1 1163540 1164313 D PF00849: RNA pseudouridylate synthase; High confidence in function and specificity; pseudouridylate synthase 1163540..1164313 Lactococcus lactis subsp. cremoris MG1363 4799069 YP_001032508.1 CDS llmg_1195 NC_009004.1 1164663 1165283 D membrane protein; hypothetical protein 1164663..1165283 Lactococcus lactis subsp. cremoris MG1363 4797377 YP_001032509.1 CDS llmg_1196 NC_009004.1 1165594 1166181 D secreted protein; hypothetical protein 1165594..1166181 Lactococcus lactis subsp. cremoris MG1363 4797196 YP_001032510.1 CDS llmg_1197 NC_009004.1 1166235 1166825 D membrane protein; hypothetical protein 1166235..1166825 Lactococcus lactis subsp. cremoris MG1363 4797716 YP_001032511.1 CDS llmg_1198 NC_009004.1 1166862 1167350 D secreted protein; hypothetical protein 1166862..1167350 Lactococcus lactis subsp. cremoris MG1363 4797151 YP_001032512.1 CDS llmg_1200 NC_009004.1 1167469 1168296 D hypothetical protein 1167469..1168296 Lactococcus lactis subsp. cremoris MG1363 4797857 YP_001032513.1 CDS llmg_1201 NC_009004.1 1168384 1168731 D Pseudogene; hypothetical protein 1168384..1168731 Lactococcus lactis subsp. cremoris MG1363 4798192 YP_001032514.1 CDS llmg_1202 NC_009004.1 1168869 1170686 D PF00005: ABC transporter TIGR02203: lipid A export ATP-binding/permease MsbA; Conserved hypothetical protein; ABC transporter ABC binding and permease 1168869..1170686 Lactococcus lactis subsp. cremoris MG1363 4798046 YP_001032515.1 CDS llmg_1203 NC_009004.1 1170670 1172454 D PF00664: ABC transporter transmembrane region, PF00005: ABC transporter TIGR02203: lipid A export ATP- binding/permease MsbA; Conserved hypothetical protein; ABC transporter ABC binding and permease 1170670..1172454 Lactococcus lactis subsp. cremoris MG1363 4799120 YP_001032516.1 CDS hdiR NC_009004.1 1172575 1173333 D IPR011056: Peptidase S24 and S26, C-terminal region, PF01381: Helix-turn-helix; Conserved hypothetical protein; HTH-type transcriptional regulator HdiR 1172575..1173333 Lactococcus lactis subsp. cremoris MG1363 4799040 YP_001032517.1 CDS llmg_1205 NC_009004.1 1173347 1173535 D membrane protein; hypothetical protein 1173347..1173535 Lactococcus lactis subsp. cremoris MG1363 4797550 YP_001032518.1 CDS rplJ NC_009004.1 1175758 1176273 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1175758..1176273 Lactococcus lactis subsp. cremoris MG1363 4797191 YP_001032519.1 CDS rplL NC_009004.1 1176343 1176708 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1176343..1176708 Lactococcus lactis subsp. cremoris MG1363 4797926 YP_001032520.1 CDS rmaX NC_009004.1 1177158 1177541 D PF01047: MarR family; Conserved hypothetical protein; MarR family transcriptional regulator 1177158..1177541 Lactococcus lactis subsp. cremoris MG1363 4797914 YP_001032521.1 CDS llmg_1210 NC_009004.1 1177542 1179101 D PF07690: Major facilitator superfamily, TIGR00711: drug resistance transporter EmrB/QacA subfamily; Conserved hypothetical protein; multidrug resistance protein 1177542..1179101 Lactococcus lactis subsp. cremoris MG1363 4798047 YP_001032522.1 CDS llmg_1211 NC_009004.1 1179098 1179934 D hypothetical protein 1179098..1179934 Lactococcus lactis subsp. cremoris MG1363 4798177 YP_001032523.1 CDS llmg_1214 NC_009004.1 1181520 1181846 D pseudogene, glycosyl transferase; hypothetical protein 1181520..1181846 Lactococcus lactis subsp. cremoris MG1363 4798563 YP_001032524.1 CDS llmg_1215 NC_009004.1 1181861 1183993 D Pseudogene, glycosyl transferase, PF00535: glycosyl transferase, family 2; hypothetical protein 1181861..1183993 Lactococcus lactis subsp. cremoris MG1363 4798094 YP_001032525.1 CDS thiM NC_009004.1 1184278 1185030 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 1184278..1185030 Lactococcus lactis subsp. cremoris MG1363 4798091 YP_001032526.1 CDS thiD1 NC_009004.1 1185043 1185843 D TIGR00097 : phosphomethylpyrimidine kinase; High confidence in function and specificity; phosphomethylpyrimidine kinase 1185043..1185843 Lactococcus lactis subsp. cremoris MG1363 4797608 YP_001032527.1 CDS thiE NC_009004.1 1185836 1186492 D PF02581: Thiamine monophosphate synthase/TENI, TIGR00693: thiamine-phosphate pyrophosphorylase; High confidence in function and specificity; thiamine-phosphate pyrophosphorylase 1185836..1186492 Lactococcus lactis subsp. cremoris MG1363 4797017 YP_001032528.1 CDS dltA NC_009004.1 1186831 1188330 D transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 1186831..1188330 Lactococcus lactis subsp. cremoris MG1363 4797046 YP_001032529.1 CDS dltB NC_009004.1 1188330 1189553 D PF03062: Membrane bound O-acyl transferase, MBOAT; Conserved hypothetical protein; protein dltB (basic membrane protein) (BMP) 1188330..1189553 Lactococcus lactis subsp. cremoris MG1363 4798915 YP_001032530.1 CDS dltC NC_009004.1 1189589 1189828 D D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 1189589..1189828 Lactococcus lactis subsp. cremoris MG1363 4798918 YP_001032531.1 CDS dltD NC_009004.1 1189818 1191104 D PF04918: DltD central region; High confidence in function and specificity; D-alanine transfer protein DltD 1189818..1191104 Lactococcus lactis subsp. cremoris MG1363 4798924 YP_001032532.1 CDS mgtA NC_009004.1 1191579 1194311 D PF00122: E1-E2 ATPase, PF00690: Cation transporter/ATPase, N-terminus; High confidence in function and specificity; cation-transporting P-ATPase 1191579..1194311 Lactococcus lactis subsp. cremoris MG1363 4796803 YP_001032533.1 CDS llmg_1224 NC_009004.1 1194404 1195057 D PF01325: Iron dependent repressor, N-terminal DNA binding domain; Conserved hypothetical protein; transcriptional regulator 1194404..1195057 Lactococcus lactis subsp. cremoris MG1363 4798916 YP_001032534.1 CDS metE NC_009004.1 1195217 1197490 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1195217..1197490 Lactococcus lactis subsp. cremoris MG1363 4796963 YP_001032535.1 CDS metF NC_009004.1 1197480 1198337 D PF02219: Methylenetetrahydrofolate reductase, TIGR00676: 5,10-methylenetetrahydrofolate reductase; High confidence in function and specificity; 5,10-methylenetetrahydrofolate reductase 1197480..1198337 Lactococcus lactis subsp. cremoris MG1363 4798873 YP_001032536.1 CDS aroH NC_009004.1 1198699 1199721 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1198699..1199721 Lactococcus lactis subsp. cremoris MG1363 4798884 YP_001032537.1 CDS llmg_1228 NC_009004.1 1199843 1200025 R Region start changed from 1200064 to 1200025 (-39 bases); hypothetical protein complement(1199843..1200025) Lactococcus lactis subsp. cremoris MG1363 4798267 YP_001032538.1 CDS llmg_1229 NC_009004.1 1200210 1200380 D hypothetical protein 1200210..1200380 Lactococcus lactis subsp. cremoris MG1363 4798224 YP_001032539.1 CDS llmg_1230 NC_009004.1 1200421 1201662 D membrane protein; hypothetical protein 1200421..1201662 Lactococcus lactis subsp. cremoris MG1363 4798188 YP_001032540.1 CDS llmg_1231 NC_009004.1 1202589 1203170 R Conserved hypothetical protein; hypothetical protein complement(1202589..1203170) Lactococcus lactis subsp. cremoris MG1363 4797129 YP_001032541.1 CDS llmg_1232 NC_009004.1 1203241 1203531 D transposase helper protein for IS904; hypothetical protein 1203241..1203531 Lactococcus lactis subsp. cremoris MG1363 4797948 YP_001032542.1 CDS tnp981 NC_009004.1 1203668 1204507 R PF00665: Integrase core domain; High confidence in function and specificity; transposase for insertion element IS981J complement(1203668..1204507) Lactococcus lactis subsp. cremoris MG1363 4797919 YP_001032543.1 CDS llmg_1234 NC_009004.1 1204519 1204779 R transposase helper protein for IS981; hypothetical protein complement(1204519..1204779) Lactococcus lactis subsp. cremoris MG1363 4797274 YP_001032544.1 CDS llmg_1235 NC_009004.1 1205420 1206076 R PF00027: Cyclic nucleotide-binding domain; Conserved hypothetical protein; cyclic nucleotide-binding domain-containing protein complement(1205420..1206076) Lactococcus lactis subsp. cremoris MG1363 4797918 YP_001032545.1 CDS llmg_1236 NC_009004.1 1206198 1206809 D membrane protein; hypothetical protein 1206198..1206809 Lactococcus lactis subsp. cremoris MG1363 4797898 YP_001032546.1 CDS ceo NC_009004.1 1207355 1208293 D High confidence in function and specificity; N5-carboxyethyl-ornithine synthase 1207355..1208293 Lactococcus lactis subsp. cremoris MG1363 4797888 YP_001032547.1 CDS cspD2 NC_009004.1 1209297 1209497 D PF00313: 'Cold-shock' DNA-binding domain; Conserved hypothetical protein; cold shock-like protein cspD2 1209297..1209497 Lactococcus lactis subsp. cremoris MG1363 4798101 YP_001032548.1 CDS llmg_1240 NC_009004.1 1210978 1212060 D PF01380: Sugar isomerase (SIS); hypothetical protein 1210978..1212060 Lactococcus lactis subsp. cremoris MG1363 4797491 YP_001032549.1 CDS llmg_1241 NC_009004.1 1212077 1212787 D pseudogene; hypothetical protein 1212077..1212787 Lactococcus lactis subsp. cremoris MG1363 4797840 YP_001032550.1 CDS llmg_1242 NC_009004.1 1212815 1213036 D pseudogene; hypothetical protein 1212815..1213036 Lactococcus lactis subsp. cremoris MG1363 4798411 YP_001032551.1 CDS llmg_1243 NC_009004.1 1213067 1215454 D endoglucanase, IPR008928: Glycoside transferase, six-hairpin; High confidence in function and specificity; hypothetical protein 1213067..1215454 Lactococcus lactis subsp. cremoris MG1363 4797458 YP_001032552.1 CDS llmg_1244 NC_009004.1 1215435 1216742 D hypothetical protein 1215435..1216742 Lactococcus lactis subsp. cremoris MG1363 4797457 YP_001032553.1 CDS llmg_1245 NC_009004.1 1216780 1217592 D hydrolase, haloacid dehalogenase-like family, TIGR00099: Cof-like hydrolase; hypothetical protein 1216780..1217592 Lactococcus lactis subsp. cremoris MG1363 4797465 YP_001032554.1 CDS arsR NC_009004.1 1217893 1218216 D High confidence in function and specificity; regulator of arsenical resistance 1217893..1218216 Lactococcus lactis subsp. cremoris MG1363 4797463 YP_001032555.1 CDS arsD NC_009004.1 1218231 1218626 D PF06953: Arsenical resistance operon trans-acting repressor ArsD; Conserved hypothetical protein; arsenical resistance operon trans-acting repressor arsD 1218231..1218626 Lactococcus lactis subsp. cremoris MG1363 4797233 YP_001032556.1 CDS arsA NC_009004.1 1218639 1220354 D PF02374: Anion-transporting ATPase, TIGR00345: arsenite-activated ATPase; High confidence in function and specificity; arsenical pump-driving ATPase 1218639..1220354 Lactococcus lactis subsp. cremoris MG1363 4797240 YP_001032557.1 CDS llmg_1249 NC_009004.1 1220371 1222032 D pyridine nucleotide-disulphide oxidoreductase, PF00070: Pyridine nucleotide-disulphide oxidoreductase; hypothetical protein 1220371..1222032 Lactococcus lactis subsp. cremoris MG1363 4798264 YP_001032558.1 CDS llmg_1250 NC_009004.1 1222048 1223100 D PF01758: Sodium Bile acid symporter family, TIGR00832: arsenical-resistance protein; Conserved hypothetical protein; arsenical-resistance protein 1222048..1223100 Lactococcus lactis subsp. cremoris MG1363 4797472 YP_001032559.1 CDS llmg_1251 NC_009004.1 1223109 1223312 D hypothetical protein 1223109..1223312 Lactococcus lactis subsp. cremoris MG1363 4797468 YP_001032560.1 CDS llmg_1252 NC_009004.1 1223857 1224258 R transcriptional regulator, IPR009061: DNA binding; hypothetical protein complement(1223857..1224258) Lactococcus lactis subsp. cremoris MG1363 4797456 YP_001032561.1 CDS llmg_1253 NC_009004.1 1224964 1225821 D aldo/keto reductase, PF00248: Aldo/keto reductase; hypothetical protein 1224964..1225821 Lactococcus lactis subsp. cremoris MG1363 4797428 YP_001032562.1 CDS llmg_1254 NC_009004.1 1226569 1226769 D hypothetical protein 1226569..1226769 Lactococcus lactis subsp. cremoris MG1363 4798225 YP_001032563.1 CDS cspC NC_009004.1 1226900 1227100 D IPR008994: Nucleic acid-binding OB-fold, PF00313: 'Cold-shock' DNA-binding domain; Conserved hypothetical protein; cold shock protein cspC 1226900..1227100 Lactococcus lactis subsp. cremoris MG1363 4797470 YP_001032564.1 CDS cspD NC_009004.1 1227378 1227578 D PF00313: Cold-shock protein, DNA-binding; Conserved hypothetical protein; cold shock protein cspD 1227378..1227578 Lactococcus lactis subsp. cremoris MG1363 4798824 YP_001032565.1 CDS llmg_1257 NC_009004.1 1228094 1228333 D membrane protein, PF04226: Transglycosylase-associated protein; hypothetical protein 1228094..1228333 Lactococcus lactis subsp. cremoris MG1363 4798833 YP_001032566.1 CDS llmg_1258 NC_009004.1 1228363 1228923 D membrane protein; hypothetical protein 1228363..1228923 Lactococcus lactis subsp. cremoris MG1363 4798744 YP_001032567.1 CDS llmg_1259 NC_009004.1 1228933 1229121 D membrane protein; hypothetical protein 1228933..1229121 Lactococcus lactis subsp. cremoris MG1363 4798462 YP_001032568.1 CDS llmg_1260 NC_009004.1 1229142 1229402 D pseudogene, general stress protein, PF03780: Protein of unknown function DUF322; hypothetical protein 1229142..1229402 Lactococcus lactis subsp. cremoris MG1363 4798450 YP_001032569.1 CDS llmg_1261 NC_009004.1 1229451 1230209 R PF01695: IstB-like ATP-binding protein; Conserved hypothetical protein; transposase helper protein for IS712F complement(1229451..1230209) Lactococcus lactis subsp. cremoris MG1363 4797366 YP_001032570.1 CDS tnp712 NC_009004.1 1230221 1231444 R PF00665: Integrase core domain; Conserved hypothetical protein; transposase for insertion sequence element IS712F complement(1230221..1231444) Lactococcus lactis subsp. cremoris MG1363 4797787 YP_001032571.1 CDS llmg_1263 NC_009004.1 1231488 1231862 D pseudogene, general stress protein, PF03780: Protein of unknown function DUF322; hypothetical protein 1231488..1231862 Lactococcus lactis subsp. cremoris MG1363 4796584 YP_001032572.1 CDS llmg_1264 NC_009004.1 1232254 1232514 D Conserved hypothetical protein; transposase helper protein for IS981 1232254..1232514 Lactococcus lactis subsp. cremoris MG1363 4799016 YP_001032573.1 CDS tnp981 NC_009004.1 1232526 1233140 D Conserved hypothetical protein; transposase for insertion sequence element IS981J 1232526..1233140 Lactococcus lactis subsp. cremoris MG1363 4798033 YP_001032574.1 CDS llmg_1267 NC_009004.1 1234522 1234869 D hypothetical protein 1234522..1234869 Lactococcus lactis subsp. cremoris MG1363 4797467 YP_001032575.1 CDS xerS NC_009004.1 1236405 1237460 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1236405..1237460 Lactococcus lactis subsp. cremoris MG1363 4797744 YP_001032576.1 CDS llmg_1269 NC_009004.1 1237544 1237831 D hypothetical protein 1237544..1237831 Lactococcus lactis subsp. cremoris MG1363 4796826 YP_001032577.1 CDS xerS NC_009004.1 1238314 1239384 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1238314..1239384 Lactococcus lactis subsp. cremoris MG1363 4798583 YP_001032578.1 CDS gidC NC_009004.1 1239434 1240780 R TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid complement(1239434..1240780) Lactococcus lactis subsp. cremoris MG1363 4798788 YP_001032579.1 CDS topA NC_009004.1 1240852 1242978 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1240852..1242978) Lactococcus lactis subsp. cremoris MG1363 4798178 YP_001032580.1 CDS smf NC_009004.1 1243244 1244092 R PF02481: SMF family, TIGR00732: DNA processing protein DprA, Conserved hypothetical protein; Smf protein complement(1243244..1244092) Lactococcus lactis subsp. cremoris MG1363 4797917 YP_001032581.1 CDS aldR NC_009004.1 1244240 1244620 R translation initiation inhibitor, PF01042: Endoribonuclease L-PSP, TIGR00004: endoribonuclease L-PSP, Conserved hypothetical protein; regulator AldR complement(1244240..1244620) Lactococcus lactis subsp. cremoris MG1363 4796684 YP_001032582.1 CDS aldB NC_009004.1 1244660 1245370 R PF03306: Alpha-acetolactate decarboxylase, TIGR01252: alpha-acetolactate decarboxylase; High confidence in function and specificity; AldB protein complement(1244660..1245370) Lactococcus lactis subsp. cremoris MG1363 4796602 YP_001032583.1 CDS ilvA NC_009004.1 1245506 1246756 R catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase complement(1245506..1246756) Lactococcus lactis subsp. cremoris MG1363 4797499 YP_001032584.1 CDS ilvC NC_009004.1 1246815 1247837 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(1246815..1247837) Lactococcus lactis subsp. cremoris MG1363 4796658 YP_001032585.1 CDS ilvH NC_009004.1 1247882 1248358 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(1247882..1248358) Lactococcus lactis subsp. cremoris MG1363 4798565 YP_001032586.1 CDS ilvB NC_009004.1 1248351 1250075 R catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit complement(1248351..1250075) Lactococcus lactis subsp. cremoris MG1363 4797629 YP_001032587.1 CDS ilvD NC_009004.1 1250090 1251802 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1250090..1251802) Lactococcus lactis subsp. cremoris MG1363 4797714 YP_001032588.1 CDS llmg_1281 NC_009004.1 1251922 1252758 R PF00005: ABC transporter; Conserved hypothetical protein; ABC transporter ATP-binding protein complement(1251922..1252758) Lactococcus lactis subsp. cremoris MG1363 4797673 YP_001032589.1 CDS leuD NC_009004.1 1252718 1253293 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(1252718..1253293) Lactococcus lactis subsp. cremoris MG1363 4799063 YP_001032590.1 CDS llmg_1283 NC_009004.1 1253342 1253875 R membrane protein; hypothetical protein complement(1253342..1253875) Lactococcus lactis subsp. cremoris MG1363 4798333 YP_001032591.1 CDS leuC NC_009004.1 1253875 1255251 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(1253875..1255251) Lactococcus lactis subsp. cremoris MG1363 4796776 YP_001032592.1 CDS llmg_1287 NC_009004.1 1258411 1259370 D PF00581: Rhodanese-like domain; hypothetical protein 1258411..1259370 Lactococcus lactis subsp. cremoris MG1363 4796611 YP_001032593.1 CDS hisK NC_009004.1 1259403 1260188 R IPR010140: Histidinol phosphate phosphatase, HisJ, TIGR01856: histidinol phosphate phosphatase HisJ family; High confidence in function and specificity; histidinol-phosphatase complement(1259403..1260188) Lactococcus lactis subsp. cremoris MG1363 4798511 YP_001032594.1 CDS hisI NC_009004.1 1260189 1260827 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase complement(1260189..1260827) Lactococcus lactis subsp. cremoris MG1363 4799118 YP_001032595.1 CDS hisF NC_009004.1 1260824 1261603 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(1260824..1261603) Lactococcus lactis subsp. cremoris MG1363 4797606 YP_001032596.1 CDS hisA NC_009004.1 1261572 1262312 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(1261572..1262312) Lactococcus lactis subsp. cremoris MG1363 4797807 YP_001032597.1 CDS hisH NC_009004.1 1262312 1262920 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(1262312..1262920) Lactococcus lactis subsp. cremoris MG1363 4798340 YP_001032598.1 CDS llmg_1293 NC_009004.1 1262971 1263759 R kanamycin kinase , PF01636: Phosphotransferase enzyme family; hypothetical protein complement(1262971..1263759) Lactococcus lactis subsp. cremoris MG1363 4798068 YP_001032599.1 CDS hisB NC_009004.1 1263756 1264355 R catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase complement(1263756..1264355) Lactococcus lactis subsp. cremoris MG1363 4798854 YP_001032600.1 CDS hisD NC_009004.1 1264356 1265663 R PF00815: Histidinol dehydrogenase, TIGR00069: histidinol dehydrogenase; High confidence in function and specificity; HisD protein complement(1264356..1265663) Lactococcus lactis subsp. cremoris MG1363 4798351 YP_001032601.1 CDS hisG NC_009004.1 1265647 1266273 R short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase complement(1265647..1266273) Lactococcus lactis subsp. cremoris MG1363 4798549 YP_001032602.1 CDS hisZ NC_009004.1 1266502 1267458 R IPR006195: Aminoacyl-transfer RNA synthetase, class II; High confidence in function and specificity; ATP phosphoribosyltransferase complement(1266502..1267458) Lactococcus lactis subsp. cremoris MG1363 4798491 YP_001032603.1 CDS hisC NC_009004.1 1267458 1268528 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(1267458..1268528) Lactococcus lactis subsp. cremoris MG1363 4798509 YP_001032604.1 CDS llmg_1299 NC_009004.1 1269077 1269691 R pseudogene, membrane protein, PF06966: Protein of unknown function DUF1295; hypothetical protein complement(1269077..1269691) Lactococcus lactis subsp. cremoris MG1363 4796813 YP_001032605.1 CDS llmg_1300 NC_009004.1 1269721 1269849 R pseudogene, membrane protein, PF06966: Protein of unknown function DUF1295; hypothetical protein complement(1269721..1269849) Lactococcus lactis subsp. cremoris MG1363 4797476 YP_001032606.1 CDS llmg_1301 NC_009004.1 1269846 1271642 R PF02645: DegV, PF02734: DAK2 domain; hypothetical protein complement(1269846..1271642) Lactococcus lactis subsp. cremoris MG1363 4797417 YP_001032607.1 CDS llmg_1302 NC_009004.1 1271646 1272047 R membrane protein; hypothetical protein complement(1271646..1272047) Lactococcus lactis subsp. cremoris MG1363 4797455 YP_001032608.1 CDS llmg_1303 NC_009004.1 1272123 1272602 R sensory protein, PF03073: TspO/MBR family; hypothetical protein complement(1272123..1272602) Lactococcus lactis subsp. cremoris MG1363 4796827 YP_001032609.1 CDS vacB2 NC_009004.1 1272922 1274925 R PF00773: RNB-like protein, TIGR02063: ribonuclease R; High confidence in function and specificity; exoribonuclease R complement(1272922..1274925) Lactococcus lactis subsp. cremoris MG1363 4796937 YP_001032610.1 CDS llmg_1305 NC_009004.1 1275130 1275462 R PF01381: Helix-turn-helix; transcriptional regulator complement(1275130..1275462) Lactococcus lactis subsp. cremoris MG1363 4798438 YP_001032611.1 CDS llmg_1306 NC_009004.1 1275928 1278375 R adhesin precursor, IPR008985: Concanavalin A-like lectin/glucanase, PF05738: Cna protein B-type domain; hypothetical protein complement(1275928..1278375) Lactococcus lactis subsp. cremoris MG1363 4797530 YP_001032612.1 CDS llmg_1308 NC_009004.1 1279042 1279197 R hypothetical protein complement(1279042..1279197) Lactococcus lactis subsp. cremoris MG1363 4797601 YP_001032613.1 CDS als NC_009004.1 1279940 1281604 R catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase complement(1279940..1281604) Lactococcus lactis subsp. cremoris MG1363 4797159 YP_001032614.1 CDS llmg_1310 NC_009004.1 1281759 1283015 R TPR domain protein; hypothetical protein complement(1281759..1283015) Lactococcus lactis subsp. cremoris MG1363 4796609 YP_001032615.1 CDS llmg_1311 NC_009004.1 1283043 1284215 R membrane protein, PF01594: Domain of unknown function DUF20; hypothetical protein complement(1283043..1284215) Lactococcus lactis subsp. cremoris MG1363 4796762 YP_001032616.1 CDS llmg_1313 NC_009004.1 1284281 1284901 R methyltransferase; hypothetical protein complement(1284281..1284901) Lactococcus lactis subsp. cremoris MG1363 4797957 YP_001032617.1 CDS llmg_1314 NC_009004.1 1284903 1286510 R hypothetical protein complement(1284903..1286510) Lactococcus lactis subsp. cremoris MG1363 4799116 YP_001032618.1 CDS llmg_1315 NC_009004.1 1286555 1287925 R TIGR00479: 23S rRNA (uracil-5-)-methyltransferase RumA, PF05958: tRNA (Uracil-5-)-methyltransferase , PF01938: TRAM domain; Conserved hypothetical protein; RNA methyltransferase complement(1286555..1287925) Lactococcus lactis subsp. cremoris MG1363 4798329 YP_001032619.1 CDS llmg_1316 NC_009004.1 1287988 1288809 R PF01380: Sugar isomerase (SIS), PF01418: Helix-turn- helix domain, rpiR family; Conserved hypothetical protein; transcriptional regulator complement(1287988..1288809) Lactococcus lactis subsp. cremoris MG1363 4797433 YP_001032620.1 CDS llmg_1317 NC_009004.1 1288947 1289651 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1288947..1289651 Lactococcus lactis subsp. cremoris MG1363 4797484 YP_001032621.1 CDS llmg_1318 NC_009004.1 1289736 1292261 R PF00122: E1-E2 ATPase, TIGR01647: plasma-membrane proton-efflux P-type ATPase; High confidence in function and specificity; cation-transporting ATPase complement(1289736..1292261) Lactococcus lactis subsp. cremoris MG1363 4796704 YP_001032622.1 CDS tnp905 NC_009004.1 1292447 1293622 D PF00872: Transposase, Mutator family; High confidence in function and specificity; transposase for insertion sequence element IS905H 1292447..1293622 Lactococcus lactis subsp. cremoris MG1363 4796723 YP_001032623.1 CDS llmg_1320 NC_009004.1 1294199 1295584 R pseudogene; Conserved hypothetical protein; xylan beta-1,4-xylosidase complement(1294199..1295584) Lactococcus lactis subsp. cremoris MG1363 4796823 YP_001032624.1 CDS llmg_1321 NC_009004.1 1295892 1297073 R Endoglucanase; hypothetical protein complement(1295892..1297073) Lactococcus lactis subsp. cremoris MG1363 4796727 YP_001032625.1 CDS llmg_1322 NC_009004.1 1297370 1298566 D multidrug efflux permease , PF07690: Major facilitator superfamily; hypothetical protein 1297370..1298566 Lactococcus lactis subsp. cremoris MG1363 4797437 YP_001032626.1 CDS tnp905 NC_009004.1 1298942 1300117 R PF00872: Transposase, Mutator family; High confidence in function and specificity; transposase for insertion sequence element IS905I complement(1298942..1300117) Lactococcus lactis subsp. cremoris MG1363 4798429 YP_001032627.1 CDS llmg_1324 NC_009004.1 1300331 1300786 D pseudogene, PF00165: Bacterial regulatory helix- turn-helix proteins, AraC type; Conserved hypothetical protein; AraC family transcriptional regulator 1300331..1300786 Lactococcus lactis subsp. cremoris MG1363 4798251 YP_001032628.1 CDS potD NC_009004.1 1301096 1302163 R Spermidine/putrescine ABC transporter substrate binding; High confidence in function and specificity; spermidine/putrescine ABC transporter substrate-binding protein complement(1301096..1302163) Lactococcus lactis subsp. cremoris MG1363 4799050 YP_001032629.1 CDS potC NC_009004.1 1302211 1303011 R High confidence in function and specificity; spermidine/putrescine ABC transporter permease complement(1302211..1303011) Lactococcus lactis subsp. cremoris MG1363 4797142 YP_001032630.1 CDS potB NC_009004.1 1303013 1303801 R High confidence in function and specificity; spermidine/putrescine ABC transporter permease complement(1303013..1303801) Lactococcus lactis subsp. cremoris MG1363 4797149 YP_001032631.1 CDS potA NC_009004.1 1303798 1305078 R High confidence in function and specificity; spermidine/putrescine ABC transporter ATP-binding protein complement(1303798..1305078) Lactococcus lactis subsp. cremoris MG1363 4796757 YP_001032632.1 CDS murB NC_009004.1 1305539 1306438 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1305539..1306438) Lactococcus lactis subsp. cremoris MG1363 4796678 YP_001032633.1 CDS llmg_1330 NC_009004.1 1306481 1307149 R Conserved hypothetical protein; hypothetical protein complement(1306481..1307149) Lactococcus lactis subsp. cremoris MG1363 4797508 YP_001032634.1 CDS thrB NC_009004.1 1307334 1308224 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1307334..1308224) Lactococcus lactis subsp. cremoris MG1363 4799049 YP_001032635.1 CDS hom NC_009004.1 1308229 1309515 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1308229..1309515) Lactococcus lactis subsp. cremoris MG1363 4796939 YP_001032636.1 CDS dukB NC_009004.1 1309696 1310334 R High confidence in function and specificity; deoxynucleoside kinase complement(1309696..1310334) Lactococcus lactis subsp. cremoris MG1363 4796698 YP_001032637.1 CDS folC NC_009004.1 1310463 1311746 R FolC protein complement(1310463..1311746) Lactococcus lactis subsp. cremoris MG1363 4798823 YP_001032638.1 CDS llmg_1335 NC_009004.1 1311762 1312262 R Also known as ylgG (AAN64308), IPR000086: NUDIX_hydrolase domain (NUcleoside DIphosphate linked to some other moiety X); hypothetical protein complement(1311762..1312262) Lactococcus lactis subsp. cremoris MG1363 4797940 YP_001032639.1 CDS folP NC_009004.1 1312265 1313338 R High confidence in function and specificity; dihydropteroate synthase complement(1312265..1313338) Lactococcus lactis subsp. cremoris MG1363 4796860 YP_001032640.1 CDS folE NC_009004.1 1313335 1314384 R FolE protein complement(1313335..1314384) Lactococcus lactis subsp. cremoris MG1363 4797323 YP_001032641.1 CDS folB NC_009004.1 1314464 1314814 R High confidence in function and specificity; FolB protein complement(1314464..1314814) Lactococcus lactis subsp. cremoris MG1363 4797968 YP_001032642.1 CDS engB NC_009004.1 1314868 1315455 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1314868..1315455) Lactococcus lactis subsp. cremoris MG1363 4798135 YP_001032643.1 CDS clpX NC_009004.1 1315452 1316687 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1315452..1316687) Lactococcus lactis subsp. cremoris MG1363 4797578 YP_001032644.1 CDS dfrA NC_009004.1 1316936 1317442 R High confidence in function and specificity; DfrA protein complement(1316936..1317442) Lactococcus lactis subsp. cremoris MG1363 4796862 YP_001032645.1 CDS spoU NC_009004.1 1317707 1318297 D rRNA methyltransferase 1317707..1318297 Lactococcus lactis subsp. cremoris MG1363 4798897 YP_001032646.1 CDS llmg_1344 NC_009004.1 1318515 1318862 D hypothetical protein 1318515..1318862 Lactococcus lactis subsp. cremoris MG1363 4797951 YP_001032647.1 CDS pbuX NC_009004.1 1318899 1320203 R High confidence in function and specificity; xanthine/uracil permease complement(1318899..1320203) Lactococcus lactis subsp. cremoris MG1363 4797006 YP_001032648.1 CDS xpt NC_009004.1 1320261 1320854 R Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase complement(1320261..1320854) Lactococcus lactis subsp. cremoris MG1363 4798145 YP_001032649.1 CDS llmg_1347 NC_009004.1 1321531 1321815 R ORF59; transcriptional regulator, IPR010982: Lambda repressor-like, DNA-binding, PF01381: Helix-turn- helix; hypothetical protein complement(1321531..1321815) Lactococcus lactis subsp. cremoris MG1363 4797864 YP_001032650.1 CDS llmg_1348 NC_009004.1 1321802 1322167 R ORF58; hypothetical protein complement(1321802..1322167) Lactococcus lactis subsp. cremoris MG1363 4797008 YP_001032651.1 CDS llmg_1349 NC_009004.1 1322595 1323665 R ORF57; integral membrane protein, PF04332: Protein of unknown function DUF475; hypothetical protein complement(1322595..1323665) Lactococcus lactis subsp. cremoris MG1363 4796953 YP_001032652.1 CDS telC NC_009004.1 1323752 1324327 R PF02342: Bacterial stress protein; Conserved hypothetical protein; tellurium resistance protein complement(1323752..1324327) Lactococcus lactis subsp. cremoris MG1363 4797011 YP_001032653.1 CDS telB NC_009004.1 1324343 1324918 R PF02342: Bacterial stress protein; Conserved hypothetical protein; tellurium resistance protein complement(1324343..1324918) Lactococcus lactis subsp. cremoris MG1363 4796966 YP_001032654.1 CDS telA NC_009004.1 1324928 1325551 R PF02342: Bacterial stress protein; Conserved hypothetical protein; tellurium resistance protein complement(1324928..1325551) Lactococcus lactis subsp. cremoris MG1363 4797061 YP_001032655.1 CDS llmg_1353 NC_009004.1 1325631 1326728 R ORF53; PF05816: Toxic anion resistance protein (TelA); tellurite resistance protein complement(1325631..1326728) Lactococcus lactis subsp. cremoris MG1363 4798216 YP_001032656.1 CDS llmg_1354 NC_009004.1 1326746 1328350 R ORF52; hypothetical protein complement(1326746..1328350) Lactococcus lactis subsp. cremoris MG1363 4797095 YP_001032657.1 CDS llmg_1355 NC_009004.1 1328376 1329197 R ORF51; hypothetical protein complement(1328376..1329197) Lactococcus lactis subsp. cremoris MG1363 4798227 YP_001032658.1 CDS llmg_1356 NC_009004.1 1329199 1330305 R ORF50; hypothetical protein complement(1329199..1330305) Lactococcus lactis subsp. cremoris MG1363 4797137 YP_001032659.1 CDS llmg_1357 NC_009004.1 1330302 1331498 R ORF49; hypothetical protein complement(1330302..1331498) Lactococcus lactis subsp. cremoris MG1363 4798036 YP_001032660.1 CDS llmg_1358 NC_009004.1 1331491 1332717 R ORF48; hypothetical protein complement(1331491..1332717) Lactococcus lactis subsp. cremoris MG1363 4797278 YP_001032661.1 CDS llmg_1359 NC_009004.1 1334029 1334313 R ORF47; transcriptional regulator, IPR010982: Lambda repressor-like, DNA-binding, PF01381: Helix-turn- helix; hypothetical protein complement(1334029..1334313) Lactococcus lactis subsp. cremoris MG1363 4797340 YP_001032662.1 CDS llmg_1360 NC_009004.1 1334300 1334665 R ORF46; hypothetical protein complement(1334300..1334665) Lactococcus lactis subsp. cremoris MG1363 4798441 YP_001032663.1 CDS xerS NC_009004.1 1334736 1335809 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS complement(1334736..1335809) Lactococcus lactis subsp. cremoris MG1363 4797858 YP_001032664.1 CDS llmg_1362 NC_009004.1 1335893 1336165 R ORF44; hypothetical protein complement(1335893..1336165) Lactococcus lactis subsp. cremoris MG1363 4797847 YP_001032665.1 CDS llmg_1364 NC_009004.1 1337148 1337708 R ORF43; hypothetical protein complement(1337148..1337708) Lactococcus lactis subsp. cremoris MG1363 4798336 YP_001032666.1 CDS llmg_1365 NC_009004.1 1338108 1338746 R ORF42; hypothetical protein complement(1338108..1338746) Lactococcus lactis subsp. cremoris MG1363 4798288 YP_001032667.1 CDS llmg_1366 NC_009004.1 1339191 1341710 R ORF41; hypothetical protein complement(1339191..1341710) Lactococcus lactis subsp. cremoris MG1363 4798126 YP_001032668.1 CDS tnp981 NC_009004.1 1342117 1342956 R High confidence in function and specificity; transposase for insertion sequence element IS981K complement(1342117..1342956) Lactococcus lactis subsp. cremoris MG1363 4796822 YP_001032669.1 CDS llmg_1368 NC_009004.1 1342968 1343228 R ORF39; transposase helper protein for IS981 complement(1342968..1343228) Lactococcus lactis subsp. cremoris MG1363 4797252 YP_001032670.1 CDS llmg_1369 NC_009004.1 1343265 1343921 R ORF38; hypothetical protein complement(1343265..1343921) Lactococcus lactis subsp. cremoris MG1363 4798029 YP_001032671.1 CDS llmg_1369a NC_009004.1 1344187 1348370 R Mobilisation protein; hypothetical protein complement(join(1344187..1345428,1347858..1348370)) Lactococcus lactis subsp. cremoris MG1363 4798958 YP_001032672.1 CDS matR NC_009004.1 1345518 1347317 R maturase complement(1345518..1347317) Lactococcus lactis subsp. cremoris MG1363 4797413 YP_001032673.1 CDS llmg_1373 NC_009004.1 1348370 1348726 R ORF34; IPR008687: Bacterial mobilisation; hypothetical protein complement(1348370..1348726) Lactococcus lactis subsp. cremoris MG1363 4798765 YP_001032674.1 CDS ltrE NC_009004.1 1348769 1349419 R DNA topoisomerase, IPR000380: DNA topoisomerase I; High confidence in function and specificity; LtrE protein complement(1348769..1349419) Lactococcus lactis subsp. cremoris MG1363 4798641 YP_001032675.1 CDS ltrD NC_009004.1 1349704 1350180 R LtrD protein complement(1349704..1350180) Lactococcus lactis subsp. cremoris MG1363 4797695 YP_001032676.1 CDS ltrC NC_009004.1 1350253 1351905 R Conserved hypothetical protein; LtrC protein complement(1350253..1351905) Lactococcus lactis subsp. cremoris MG1363 4797640 YP_001032677.1 CDS llmg_1377 NC_009004.1 1351957 1353723 R ORF30; hypothetical protein complement(1351957..1353723) Lactococcus lactis subsp. cremoris MG1363 4797689 YP_001032678.1 CDS llmg_1378 NC_009004.1 1353704 1354219 R ORF29; hypothetical protein complement(1353704..1354219) Lactococcus lactis subsp. cremoris MG1363 4798507 YP_001032679.1 CDS llmg_1379 NC_009004.1 1354233 1355417 R ORF28; Conserved hypothetical protein; Zn peptidase complement(1354233..1355417) Lactococcus lactis subsp. cremoris MG1363 4798023 YP_001032680.1 CDS llmg_1381 NC_009004.1 1355479 1355673 R ORF27; hypothetical protein complement(1355479..1355673) Lactococcus lactis subsp. cremoris MG1363 4798778 YP_001032681.1 CDS llmg_1382 NC_009004.1 1355782 1356846 R ORF26; hypothetical protein complement(1355782..1356846) Lactococcus lactis subsp. cremoris MG1363 4796872 YP_001032682.1 CDS traD NC_009004.1 1356872 1358710 R PF02534: TraG/TraD family; Conserved hypothetical protein; conjugal transfer protein TraD complement(1356872..1358710) Lactococcus lactis subsp. cremoris MG1363 4796645 YP_001032683.1 CDS llmg_1384 NC_009004.1 1358707 1359210 R ORF24; hypothetical protein complement(1358707..1359210) Lactococcus lactis subsp. cremoris MG1363 4797163 YP_001032684.1 CDS llmg_1385 NC_009004.1 1359189 1359407 R ORF23; hypothetical protein complement(1359189..1359407) Lactococcus lactis subsp. cremoris MG1363 4798471 YP_001032685.1 CDS llmg_1386 NC_009004.1 1359423 1360736 R ORF22; Conserved hypothetical protein; hypothetical protein complement(1359423..1360736) Lactococcus lactis subsp. cremoris MG1363 4798559 YP_001032686.1 CDS llmg_1387 NC_009004.1 1360736 1360981 R ORF21; Specificity unclear; hypothetical protein complement(1360736..1360981) Lactococcus lactis subsp. cremoris MG1363 4798852 YP_001032687.1 CDS llmg_1388 NC_009004.1 1360982 1361674 R ORF20; membrane protein; hypothetical protein complement(1360982..1361674) Lactococcus lactis subsp. cremoris MG1363 4798858 YP_001032688.1 CDS llmg_1389 NC_009004.1 1361700 1362017 R ORF19; hypothetical protein complement(1361700..1362017) Lactococcus lactis subsp. cremoris MG1363 4797111 YP_001032689.1 CDS llmg_1390 NC_009004.1 1362027 1364639 R ORF18; hypothetical protein complement(1362027..1364639) Lactococcus lactis subsp. cremoris MG1363 4796960 YP_001032690.1 CDS llmg_1391 NC_009004.1 1364643 1366889 R Region start changed from 1367033 to 1366889 (-144 bases); hypothetical protein complement(1364643..1366889) Lactococcus lactis subsp. cremoris MG1363 4798100 YP_001032691.1 CDS llmg_1392 NC_009004.1 1366987 1367340 R ORF16; hypothetical protein complement(1366987..1367340) Lactococcus lactis subsp. cremoris MG1363 4797119 YP_001032692.1 CDS llmg_1393 NC_009004.1 1367342 1368130 R ORF15; hypothetical protein complement(1367342..1368130) Lactococcus lactis subsp. cremoris MG1363 4796887 YP_001032693.1 CDS llmg_1395 NC_009004.1 1368421 1368819 R ORF14; hypothetical protein complement(1368421..1368819) Lactococcus lactis subsp. cremoris MG1363 4796974 YP_001032694.1 CDS llmg_1396 NC_009004.1 1368792 1368962 R ORF13; hypothetical protein complement(1368792..1368962) Lactococcus lactis subsp. cremoris MG1363 4796843 YP_001032695.1 CDS llmg_1397 NC_009004.1 1368981 1369139 R ORF12; hypothetical protein complement(1368981..1369139) Lactococcus lactis subsp. cremoris MG1363 4798163 YP_001032696.1 CDS cluA NC_009004.1 1369190 1372921 R Bacterial adhesion involved in high frequency conjugation, peptidoglycan linked, gram positive LPXTG cell wall anchor, signal peptide; High confidence in function and specificity; cell surface antigen I/II precursor complement(1369190..1372921) Lactococcus lactis subsp. cremoris MG1363 4798533 YP_001032697.1 CDS llmg_1399 NC_009004.1 1373131 1374153 R ORF10; hypothetical protein complement(1373131..1374153) Lactococcus lactis subsp. cremoris MG1363 4797960 YP_001032698.1 CDS llmg_1400 NC_009004.1 1374171 1374470 R ORF9; PF00226: DnaJ domain; hypothetical protein complement(1374171..1374470) Lactococcus lactis subsp. cremoris MG1363 4798566 YP_001032699.1 CDS llmg_1402 NC_009004.1 1375104 1375466 R ORF8; hypothetical protein complement(1375104..1375466) Lactococcus lactis subsp. cremoris MG1363 4796795 YP_001032700.1 CDS llmg_1403 NC_009004.1 1375896 1376435 R ORF7; hypothetical protein complement(1375896..1376435) Lactococcus lactis subsp. cremoris MG1363 4799062 YP_001032701.1 CDS llmg_1406 NC_009004.1 1376846 1377109 R ORF6; hypothetical protein complement(1376846..1377109) Lactococcus lactis subsp. cremoris MG1363 4796798 YP_001032702.1 CDS llmg_1407 NC_009004.1 1377114 1377311 R ORF5; hypothetical protein complement(1377114..1377311) Lactococcus lactis subsp. cremoris MG1363 4798508 YP_001032703.1 CDS llmg_1408 NC_009004.1 1377325 1377522 R ORF4; hypothetical protein complement(1377325..1377522) Lactococcus lactis subsp. cremoris MG1363 4798889 YP_001032704.1 CDS llmg_1409 NC_009004.1 1377548 1378417 R ORF3; hypothetical protein complement(1377548..1378417) Lactococcus lactis subsp. cremoris MG1363 4798074 YP_001032705.1 CDS llmg_1410 NC_009004.1 1378410 1378865 R ORF2; hypothetical protein complement(1378410..1378865) Lactococcus lactis subsp. cremoris MG1363 4798108 YP_001032706.1 CDS llmg_1411 NC_009004.1 1379125 1380063 R ORF1; hypothetical protein complement(1379125..1380063) Lactococcus lactis subsp. cremoris MG1363 4798659 YP_001032707.1 CDS guaC NC_009004.1 1380599 1381588 R High confidence in function and specificity; guanosine 5'-monophosphate oxidoreductase complement(1380599..1381588) Lactococcus lactis subsp. cremoris MG1363 4798556 YP_001032708.1 CDS llmg_1413 NC_009004.1 1381851 1382468 R Protein of unknown function DUF1461; Family membership; hypothetical protein complement(1381851..1382468) Lactococcus lactis subsp. cremoris MG1363 4797528 YP_001032709.1 CDS nagD NC_009004.1 1382610 1383383 R phosphatases involved in N-acetyl- glucosamine catabolism, TIGR01457: HAD-SF-IIA-hyp2: HAD- superfamily subfamily IIA hydrolase; High confidence in function and specificity; N-acetylglucosamine catabolic protein complement(1382610..1383383) Lactococcus lactis subsp. cremoris MG1363 4798077 YP_001032710.1 CDS llmg_1415 NC_009004.1 1383432 1384163 R Acyl-ACP thioesterase, oleoyl- acyl carrier protein thioesterase; hypothetical protein complement(1383432..1384163) Lactococcus lactis subsp. cremoris MG1363 4797574 YP_001032711.1 CDS llmg_1416 NC_009004.1 1384265 1384705 R hypothetical protein complement(1384265..1384705) Lactococcus lactis subsp. cremoris MG1363 4798842 YP_001032712.1 CDS llmg_1417 NC_009004.1 1384807 1385622 R autolytic lysozyme; Conserved hypothetical protein; hypothetical protein complement(1384807..1385622) Lactococcus lactis subsp. cremoris MG1363 4796816 YP_001032713.1 CDS hemN NC_009004.1 1385668 1386807 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1385668..1386807) Lactococcus lactis subsp. cremoris MG1363 4796787 YP_001032714.1 CDS llmg_1419 NC_009004.1 1386995 1387522 R Conserved hypothetical protein; transcriptional regulator complement(1386995..1387522) Lactococcus lactis subsp. cremoris MG1363 4797565 YP_001032715.1 CDS llmg_1420 NC_009004.1 1387504 1388823 R hypothetical protein complement(1387504..1388823) Lactococcus lactis subsp. cremoris MG1363 4799064 YP_001032716.1 CDS llmg_1421 NC_009004.1 1389161 1389562 R hypothetical protein complement(1389161..1389562) Lactococcus lactis subsp. cremoris MG1363 4796773 YP_001032717.1 CDS pacA NC_009004.1 1389794 1390711 R PF02275.7: Linear amide C-N hydrolases, choloylglycine hydrolase; High confidence in function and specificity; penicillin acylase complement(1389794..1390711) Lactococcus lactis subsp. cremoris MG1363 4798501 YP_001032718.1 CDS tpiA NC_009004.1 1390877 1391635 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1390877..1391635) Lactococcus lactis subsp. cremoris MG1363 4799076 YP_001032719.1 CDS llmg_1425 NC_009004.1 1391768 1392619 R PF01380.10: Contains sugar isomerase (SIS) domain., PF01418.7: Helix-turn-helix protein RpiR; Conserved hypothetical protein; RpiR family transcriptional regulator complement(1391768..1392619) Lactococcus lactis subsp. cremoris MG1363 4798326 YP_001032720.1 CDS llmg_1426 NC_009004.1 1392681 1394633 R High confidence in function and specificity; sucrose-specific PTS system IIBC component complement(1392681..1394633) Lactococcus lactis subsp. cremoris MG1363 4798564 YP_001032721.1 CDS murQ NC_009004.1 1394669 1395562 R catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase complement(1394669..1395562) Lactococcus lactis subsp. cremoris MG1363 4799122 YP_001032722.1 CDS llmg_1428 NC_009004.1 1395555 1396616 R Bacterial protein of unknown function DUF871; hypothetical protein complement(1395555..1396616) Lactococcus lactis subsp. cremoris MG1363 4799052 YP_001032723.1 CDS ldhX NC_009004.1 1396766 1397737 R High confidence in function and specificity; L-lactate dehydrogenase complement(1396766..1397737) Lactococcus lactis subsp. cremoris MG1363 4798805 YP_001032724.1 CDS ribC NC_009004.1 1397821 1398723 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(1397821..1398723) Lactococcus lactis subsp. cremoris MG1363 4796614 YP_001032725.1 CDS truB NC_009004.1 1398755 1399747 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1398755..1399747) Lactococcus lactis subsp. cremoris MG1363 4798154 YP_001032726.1 CDS llmg_1432 NC_009004.1 1399886 1400605 R hypothetical protein complement(1399886..1400605) Lactococcus lactis subsp. cremoris MG1363 4798203 YP_001032727.1 CDS llmg_1433 NC_009004.1 1400795 1403095 R PF00478: IMP dehydrogenase / GMP reductase domain; Conserved hypothetical protein; hypothetical protein complement(1400795..1403095) Lactococcus lactis subsp. cremoris MG1363 4797694 YP_001032728.1 CDS llmg_1434 NC_009004.1 1403462 1403986 D Conserved hypothetical protein; hypothetical protein 1403462..1403986 Lactococcus lactis subsp. cremoris MG1363 4797713 YP_001032729.1 CDS llmg_1435 NC_009004.1 1404048 1404506 D hypothetical protein 1404048..1404506 Lactococcus lactis subsp. cremoris MG1363 4798370 YP_001032730.1 CDS tnp981 NC_009004.1 1404756 1405595 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981L complement(1404756..1405595) Lactococcus lactis subsp. cremoris MG1363 4798383 YP_001032731.1 CDS llmg_1438 NC_009004.1 1405607 1405867 R transposase helper protein for IS981; hypothetical protein complement(1405607..1405867) Lactococcus lactis subsp. cremoris MG1363 4797247 YP_001032732.1 CDS llmg_1440 NC_009004.1 1406092 1407036 R Protein kinase-like; Family membership; hypothetical protein complement(1406092..1407036) Lactococcus lactis subsp. cremoris MG1363 4798387 YP_001032733.1 CDS frdC NC_009004.1 1407163 1408671 R Reduces fumarate to succinate in anaerobic bacterial respiration; fumarate reductase flavoprotein subunit complement(1407163..1408671) Lactococcus lactis subsp. cremoris MG1363 4797182 YP_001032734.1 CDS llmg_1442 NC_009004.1 1408847 1409296 R Family membership; hypothetical protein complement(1408847..1409296) Lactococcus lactis subsp. cremoris MG1363 4797861 YP_001032735.1 CDS mutX NC_009004.1 1409997 1410464 R contains NUDIX domain; High confidence in function and specificity; ADP-ribose pyrophosphatase complement(1409997..1410464) Lactococcus lactis subsp. cremoris MG1363 4798735 YP_001032736.1 CDS pcrA NC_009004.1 1410489 1412765 R High confidence in function and specificity; ATP-dependent DNA helicase complement(1410489..1412765) Lactococcus lactis subsp. cremoris MG1363 4798182 YP_001032737.1 CDS llmg_1446 NC_009004.1 1412917 1413693 D hypothetical protein 1412917..1413693 Lactococcus lactis subsp. cremoris MG1363 4798140 YP_001032738.1 CDS llmg_1447 NC_009004.1 1413638 1414267 R Conserved hypothetical protein; hypothetical protein complement(1413638..1414267) Lactococcus lactis subsp. cremoris MG1363 4797157 YP_001032739.1 CDS llmg_1448 NC_009004.1 1414254 1417007 R C-terminal end; Specificity unclear; hypothetical protein complement(1414254..1417007) Lactococcus lactis subsp. cremoris MG1363 4796629 YP_001032740.1 CDS srtA NC_009004.1 1417226 1417978 R High confidence in function and specificity; sortase SrtA complement(1417226..1417978) Lactococcus lactis subsp. cremoris MG1363 4796566 YP_001032741.1 CDS apbE NC_009004.1 1418101 1419186 R High confidence in function and specificity; thiamine biosynthesis lipoprotein apbE precursor complement(1418101..1419186) Lactococcus lactis subsp. cremoris MG1363 4799114 YP_001032742.1 CDS gyrA NC_009004.1 1419268 1421778 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1419268..1421778) Lactococcus lactis subsp. cremoris MG1363 4798945 YP_001032743.1 CDS llmg_1452 NC_009004.1 1422000 1423469 R Contains Amino acid permease-associated region; Function unclear; amino-acid permease complement(1422000..1423469) Lactococcus lactis subsp. cremoris MG1363 4797540 YP_001032744.1 CDS llmg_1453 NC_009004.1 1423642 1424277 R Similar to nucleoside-diphosphate-sugar epimerases; Conserved hypothetical protein; oxidoreductase complement(1423642..1424277) Lactococcus lactis subsp. cremoris MG1363 4796724 YP_001032745.1 CDS llmg_1454 NC_009004.1 1424379 1425326 R ROK_glcA_fam: ROK family protein ( glucokinase), Similar to xylose repressor protein; Specificity unclear; sugar kinase complement(1424379..1425326) Lactococcus lactis subsp. cremoris MG1363 4796702 YP_001032746.1 CDS bglA2 NC_009004.1 1425329 1426771 R Glycoside hydrolase, family 1; High confidence in function and specificity; 6-phospho-beta-glucosidase complement(1425329..1426771) Lactococcus lactis subsp. cremoris MG1363 4798171 YP_001032747.1 CDS bglX NC_009004.1 1426768 1428912 R Glycoside hydrolase, family 3; High confidence in function and specificity; beta-glucosidase complement(1426768..1428912) Lactococcus lactis subsp. cremoris MG1363 4797229 YP_001032748.1 CDS llmg_1457 NC_009004.1 1428989 1430053 R oligo_HPY: oligopeptide/dipeptide ABC transporter ATP-binding protein; Specificity unclear; di/Tri-peptide transport ATP-binding protein complement(1428989..1430053) Lactococcus lactis subsp. cremoris MG1363 4798448 YP_001032749.1 CDS llmg_1458 NC_009004.1 1430053 1431072 R Specificity unclear; di/Tri-peptide transport system permease complement(1430053..1431072) Lactococcus lactis subsp. cremoris MG1363 4799139 YP_001032750.1 CDS llmg_1459 NC_009004.1 1431074 1432054 R Specificity unclear; di/Tri-peptide transport system permease complement(1431074..1432054) Lactococcus lactis subsp. cremoris MG1363 4799111 YP_001032751.1 CDS llmg_1460 NC_009004.1 1432054 1433154 R Specificity unclear; di/Tri-peptide transport ATP-binding protein complement(1432054..1433154) Lactococcus lactis subsp. cremoris MG1363 4799125 YP_001032752.1 CDS llmg_1461 NC_009004.1 1433227 1434771 R Specificity unclear; di/Tri-peptide binding protein precursor complement(1433227..1434771) Lactococcus lactis subsp. cremoris MG1363 4797777 YP_001032753.1 CDS llmg_1462 NC_009004.1 1435163 1435888 R Contains sugar isomerase (SIS)domain; Family membership; HTH-type transcriptional regulator complement(1435163..1435888) Lactococcus lactis subsp. cremoris MG1363 4797776 YP_001032754.1 CDS lepA NC_009004.1 1436035 1437858 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1436035..1437858) Lactococcus lactis subsp. cremoris MG1363 4797775 YP_001032755.1 CDS aldC NC_009004.1 1438148 1438813 R High confidence in function and specificity; AldC protein complement(1438148..1438813) Lactococcus lactis subsp. cremoris MG1363 4797048 YP_001032756.1 CDS murC2 NC_009004.1 1438912 1440261 D High confidence in function and specificity; UDP-N-acetylmuramyl tripeptide synthetase 1438912..1440261 Lactococcus lactis subsp. cremoris MG1363 4797642 YP_001032757.1 CDS cobQ NC_009004.1 1440262 1441047 D CobB/CobQ-like glutamine amidotransferase; High confidence in function and specificity; cobyric acid synthase 1440262..1441047 Lactococcus lactis subsp. cremoris MG1363 4797423 YP_001032758.1 CDS llmg_1467 NC_009004.1 1441125 1443806 R Similar to ABC-type antimicrobial peptide transport system, permease component; Specificity unclear; ABC transporter permease complement(1441125..1443806) Lactococcus lactis subsp. cremoris MG1363 4798086 YP_001032759.1 CDS llmg_1468 NC_009004.1 1443810 1444511 R Specificity unclear; ABC transporter ATP-binding protein complement(1443810..1444511) Lactococcus lactis subsp. cremoris MG1363 4797774 YP_001032760.1 CDS nadE NC_009004.1 1444713 1445537 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1444713..1445537) Lactococcus lactis subsp. cremoris MG1363 4797773 YP_001032761.1 CDS llmg_1471 NC_009004.1 1445594 1446082 R GCN5-related N-acetyltransferase; Family membership; acetyltransferase complement(1445594..1446082) Lactococcus lactis subsp. cremoris MG1363 4797079 YP_001032762.1 CDS pncB NC_009004.1 1446079 1447551 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1446079..1447551) Lactococcus lactis subsp. cremoris MG1363 4797772 YP_001032763.1 CDS nadD NC_009004.1 1448134 1448727 D transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1448134..1448727 Lactococcus lactis subsp. cremoris MG1363 4799109 YP_001032764.1 CDS llmg_1474 NC_009004.1 1448742 1449953 R Cl- channel, voltage gated, Voltage gated chloride channel; Specificity unclear; voltage gated chloride channel complement(1448742..1449953) Lactococcus lactis subsp. cremoris MG1363 4798194 YP_001032765.1 CDS llmg_1475 NC_009004.1 1450356 1450598 R Bacterial protein of unknown function DUF896; hypothetical protein complement(1450356..1450598) Lactococcus lactis subsp. cremoris MG1363 4797771 YP_001032766.1 CDS glyS NC_009004.1 1450705 1452726 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1450705..1452726) Lactococcus lactis subsp. cremoris MG1363 4797769 YP_001032767.1 CDS glyQ NC_009004.1 1452726 1453679 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1452726..1453679) Lactococcus lactis subsp. cremoris MG1363 4798752 YP_001032768.1 CDS nucA NC_009004.1 1453908 1454675 R High confidence in function and specificity; 5'-nucleotidase complement(1453908..1454675) Lactococcus lactis subsp. cremoris MG1363 4798743 YP_001032769.1 CDS llmg_1480 NC_009004.1 1454785 1455804 R Protein of unknown function DUF475; Conserved hypothetical protein; hypothetical protein complement(1454785..1455804) Lactococcus lactis subsp. cremoris MG1363 4798584 YP_001032770.1 CDS vanZ NC_009004.1 1455870 1456370 R VanZ like protein; Function unclear; teicoplanin resistance protein complement(1455870..1456370) Lactococcus lactis subsp. cremoris MG1363 4797768 YP_001032771.1 CDS llmg_1482 NC_009004.1 1456412 1457047 R Protein of unknown function UPF0029; hypothetical protein complement(1456412..1457047) Lactococcus lactis subsp. cremoris MG1363 4798422 YP_001032772.1 CDS comFA NC_009004.1 1457104 1458396 D DEAD/DEAH box helicase, N-terminal, competence protein; Function unclear; superfamily II DNA/RNA helicase 1457104..1458396 Lactococcus lactis subsp. cremoris MG1363 4797767 YP_001032773.1 CDS comFC NC_009004.1 1458396 1459046 D comF: comF family protein, Similar to amidophosphoribosyltransferases; Function unclear; late competence protein 1458396..1459046 Lactococcus lactis subsp. cremoris MG1363 4798782 YP_001032774.1 CDS llmg_1485 NC_009004.1 1459105 1459683 R Bacterial protein of unknown function DUF925; hypothetical protein complement(1459105..1459683) Lactococcus lactis subsp. cremoris MG1363 4798784 YP_001032775.1 CDS dgkA NC_009004.1 1459700 1460155 R High confidence in function and specificity; DgkA protein complement(1459700..1460155) Lactococcus lactis subsp. cremoris MG1363 4797766 YP_001032776.1 CDS llmg_1487 NC_009004.1 1460139 1460627 R Protein of unknown function UPF0054; metalloprotease complement(1460139..1460627) Lactococcus lactis subsp. cremoris MG1363 4798899 YP_001032777.1 CDS llmg_1488 NC_009004.1 1460857 1461345 R contains NUDIX domain; Family membership; hydrolase complement(1460857..1461345) Lactococcus lactis subsp. cremoris MG1363 4797765 YP_001032778.1 CDS phoH NC_009004.1 1461415 1462383 R phosphate starvation inducible protein; High confidence in function and specificity; PhoH-like protein complement(1461415..1462383) Lactococcus lactis subsp. cremoris MG1363 4797762 YP_001032779.1 CDS mntH NC_009004.1 1462457 1463989 R nramp: NRAMP family Mn2+/Fe2+ transporters; High confidence in function and specificity; proton-dependent manganese transporter group C beta complement(1462457..1463989) Lactococcus lactis subsp. cremoris MG1363 4798552 YP_001032780.1 CDS rpmA NC_009004.1 1464261 1464545 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1464261..1464545) Lactococcus lactis subsp. cremoris MG1363 4797431 YP_001032781.1 CDS llmg_1492 NC_009004.1 1464547 1464882 R Protein of unknown function DUF464; hypothetical protein complement(1464547..1464882) Lactococcus lactis subsp. cremoris MG1363 4799030 YP_001032782.1 CDS rplU NC_009004.1 1464885 1465199 R High confidence in function and specificity; 50S ribosomal protein L21 complement(1464885..1465199) Lactococcus lactis subsp. cremoris MG1363 4797761 YP_001032783.1 CDS llmg_1494 NC_009004.1 1465369 1466544 R Conserved hypothetical protein; ABC transporter permease complement(1465369..1466544) Lactococcus lactis subsp. cremoris MG1363 4797845 YP_001032784.1 CDS llmg_1495 NC_009004.1 1466537 1466935 R hypothetical protein complement(1466537..1466935) Lactococcus lactis subsp. cremoris MG1363 4797760 YP_001032785.1 CDS llmg_1496 NC_009004.1 1467108 1468451 D metal-dependent phosphohydrolase, contains HD region; Family membership; phosphohydrolase 1467108..1468451 Lactococcus lactis subsp. cremoris MG1363 4797759 YP_001032786.1 CDS llmg_1497 NC_009004.1 1468504 1469319 D Cof-subfamily: Cof-like hydrolase; Family membership; hydrolase 1468504..1469319 Lactococcus lactis subsp. cremoris MG1363 4797758 YP_001032787.1 CDS llmg_1498 NC_009004.1 1469458 1469823 D hypothetical protein 1469458..1469823 Lactococcus lactis subsp. cremoris MG1363 4797757 YP_001032788.1 CDS llmg_1499 NC_009004.1 1469857 1470630 R NIF3 (NGG1p interacting factor 3) like protein; hypothetical protein complement(1469857..1470630) Lactococcus lactis subsp. cremoris MG1363 4797756 YP_001032789.1 CDS llmg_1500 NC_009004.1 1470627 1471316 R Similar to SAM-dependent methyltransferases; Conserved hypothetical protein; methyltransferase complement(1470627..1471316) Lactococcus lactis subsp. cremoris MG1363 4797755 YP_001032790.1 CDS nth NC_009004.1 1471309 1471965 R HhH-GPD superfamily base excision DNA repair protein; High confidence in function and specificity; endonuclease III complement(1471309..1471965) Lactococcus lactis subsp. cremoris MG1363 4797754 YP_001032791.1 CDS dnaD NC_009004.1 1471987 1472655 R DnaD-like domain; High confidence in function and specificity; DNA replication protein dnaD complement(1471987..1472655) Lactococcus lactis subsp. cremoris MG1363 4796778 YP_001032792.1 CDS llmg_1503 NC_009004.1 1472921 1475113 R TIGR02167: Bacterial surface protein 26-residue repeat; Family membership; surface protein complement(1472921..1475113) Lactococcus lactis subsp. cremoris MG1363 4798378 YP_001032793.1 CDS llmg_1504 NC_009004.1 1475575 1475691 D hypothetical protein 1475575..1475691 Lactococcus lactis subsp. cremoris MG1363 4797753 YP_001032794.1 CDS llmg_1505 NC_009004.1 1475841 1476767 R hypothetical protein complement(1475841..1476767) Lactococcus lactis subsp. cremoris MG1363 4797752 YP_001032795.1 CDS llmg_1506 NC_009004.1 1476975 1480778 R SSF49313: cadherin, PF07523.2: Bacterial Ig-like, SSF50447: Translation factor, TIGR01167: Surface protein from Gram-positive cocci, anchor region; hypothetical protein complement(1476975..1480778) Lactococcus lactis subsp. cremoris MG1363 4797751 YP_001032796.1 CDS llmg_1507 NC_009004.1 1480957 1482024 R SM00671: Sel1-like repeat, contains HTH motif; Family membership; hypothetical protein complement(1480957..1482024) Lactococcus lactis subsp. cremoris MG1363 4797741 YP_001032797.1 CDS pyrC NC_009004.1 1482282 1483553 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1482282..1483553) Lactococcus lactis subsp. cremoris MG1363 4797740 YP_001032798.1 CDS pyrE NC_009004.1 1483705 1484334 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(1483705..1484334) Lactococcus lactis subsp. cremoris MG1363 4797637 YP_001032799.1 CDS llmg_1512 NC_009004.1 1484827 1486734 R Function unclear; ABC transporter ATP-binding protein complement(1484827..1486734) Lactococcus lactis subsp. cremoris MG1363 4797715 YP_001032800.1 CDS llmg_1513 NC_009004.1 1486907 1487299 R arsC_related: conserved hypothetical protein, Similar to Regulatory protein spx; hypothetical protein complement(1486907..1487299) Lactococcus lactis subsp. cremoris MG1363 4797739 YP_001032801.1 CDS rex NC_009004.1 1487522 1488172 D modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 1487522..1488172 Lactococcus lactis subsp. cremoris MG1363 4797738 YP_001032802.1 CDS radC NC_009004.1 1488359 1489042 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(1488359..1489042) Lactococcus lactis subsp. cremoris MG1363 4796930 YP_001032803.1 CDS glmS NC_009004.1 1489160 1490977 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(1489160..1490977) Lactococcus lactis subsp. cremoris MG1363 4799102 YP_001032804.1 CDS llmg_1517 NC_009004.1 1491159 1491815 R phosphatidic acid phosphatase complement(1491159..1491815) Lactococcus lactis subsp. cremoris MG1363 4798024 YP_001032805.1 CDS kinE NC_009004.1 1491825 1493150 R High confidence in function and specificity; sensor kinase complement(1491825..1493150) Lactococcus lactis subsp. cremoris MG1363 4797737 YP_001032806.1 CDS llmg_1519 NC_009004.1 1493154 1493669 R Conserved hypothetical protein; hypothetical protein complement(1493154..1493669) Lactococcus lactis subsp. cremoris MG1363 4796649 YP_001032807.1 CDS llrE NC_009004.1 1493690 1494376 R Response regulator receiver domain; High confidence in function and specificity; two-component system regulator llrE complement(1493690..1494376) Lactococcus lactis subsp. cremoris MG1363 4797736 YP_001032808.1 CDS llmg_1521 NC_009004.1 1494504 1495460 R Family membership; glycosyl transferase family protein complement(1494504..1495460) Lactococcus lactis subsp. cremoris MG1363 4796707 YP_001032809.1 CDS llmg_1522 NC_009004.1 1495463 1497100 R Conserved hypothetical protein; hypothetical protein complement(1495463..1497100) Lactococcus lactis subsp. cremoris MG1363 4797750 YP_001032810.1 CDS llmg_1523 NC_009004.1 1497243 1497686 R Similar to acid phosphatase/vanadium-dependent haloperoxidases; hypothetical protein complement(1497243..1497686) Lactococcus lactis subsp. cremoris MG1363 4797749 YP_001032811.1 CDS rluD NC_009004.1 1497844 1498749 R High confidence in function and specificity; ribosomal large subunit pseudouridine synthase D complement(1497844..1498749) Lactococcus lactis subsp. cremoris MG1363 4797748 YP_001032812.1 CDS lspA NC_009004.1 1498812 1499264 R lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase complement(1498812..1499264) Lactococcus lactis subsp. cremoris MG1363 4796771 YP_001032813.1 CDS llmg_1526 NC_009004.1 1499553 1499933 R hypothetical protein complement(1499553..1499933) Lactococcus lactis subsp. cremoris MG1363 4799080 YP_001032814.1 CDS llmg_1527 NC_009004.1 1500033 1500431 D Family membership; transcriptional regulator 1500033..1500431 Lactococcus lactis subsp. cremoris MG1363 4797747 YP_001032815.1 CDS llmg_1528 NC_009004.1 1500713 1500937 D hypothetical protein 1500713..1500937 Lactococcus lactis subsp. cremoris MG1363 4797746 YP_001032816.1 CDS ribH NC_009004.1 1501033 1501497 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(1501033..1501497) Lactococcus lactis subsp. cremoris MG1363 4797745 YP_001032817.1 CDS ribA NC_009004.1 1501524 1502720 R 3,4-dihydroxy-2-butanone 4-phosphate synthase, GTP cyclohydrolase II; High confidence in function and specificity; riboflavin biosynthesis protein ribA complement(1501524..1502720) Lactococcus lactis subsp. cremoris MG1363 4797735 YP_001032818.1 CDS ribB NC_009004.1 1502732 1503379 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1502732..1503379) Lactococcus lactis subsp. cremoris MG1363 4797066 YP_001032819.1 CDS ribD NC_009004.1 1503379 1504467 R riboflavin biosynthesis protein RibD complement(1503379..1504467) Lactococcus lactis subsp. cremoris MG1363 4797148 YP_001032820.1 CDS llmg_1533 NC_009004.1 1504959 1505864 D Mg2+ and Co2+ transporter protein, CorA-like; Conserved hypothetical protein; magnesium and cobalt transport protein 1504959..1505864 Lactococcus lactis subsp. cremoris MG1363 4798233 YP_001032821.1 CDS parC NC_009004.1 1505890 1508364 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(1505890..1508364) Lactococcus lactis subsp. cremoris MG1363 4797734 YP_001032822.1 CDS elaA NC_009004.1 1508689 1509138 R GCN5-related N-acetyltransferase; Conserved hypothetical protein; ElaA protein complement(1508689..1509138) Lactococcus lactis subsp. cremoris MG1363 4798129 YP_001032823.1 CDS dnaQ NC_009004.1 1509135 1509968 R High confidence in function and specificity; DNA polymerase III subunit epsilon complement(1509135..1509968) Lactococcus lactis subsp. cremoris MG1363 4797529 YP_001032824.1 CDS llmg_1538 NC_009004.1 1509961 1510542 R High confidence in function and specificity; isochorismatase complement(1509961..1510542) Lactococcus lactis subsp. cremoris MG1363 4798398 YP_001032825.1 CDS parE NC_009004.1 1510604 1512538 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(1510604..1512538) Lactococcus lactis subsp. cremoris MG1363 4797733 YP_001032826.1 CDS llmg_1540 NC_009004.1 1512817 1513458 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 1512817..1513458 Lactococcus lactis subsp. cremoris MG1363 4798139 YP_001032827.1 CDS nrdH NC_009004.1 1513632 1513850 D High confidence in function and specificity; glutaredoxin-like protein nrdH 1513632..1513850 Lactococcus lactis subsp. cremoris MG1363 4798360 YP_001032828.1 CDS nrdI NC_009004.1 1513852 1514274 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1513852..1514274 Lactococcus lactis subsp. cremoris MG1363 4797260 YP_001032829.1 CDS nrdE NC_009004.1 1514411 1516579 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1514411..1516579 Lactococcus lactis subsp. cremoris MG1363 4797357 YP_001032830.1 CDS nrdF NC_009004.1 1516864 1517841 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1516864..1517841 Lactococcus lactis subsp. cremoris MG1363 4797076 YP_001032831.1 CDS ftsX NC_009004.1 1517951 1518886 R High confidence in function and specificity; cell division protein FtsX complement(1517951..1518886) Lactococcus lactis subsp. cremoris MG1363 4798066 YP_001032832.1 CDS ftsE NC_009004.1 1518879 1519571 R High confidence in function and specificity; cell division ATP-binding protein complement(1518879..1519571) Lactococcus lactis subsp. cremoris MG1363 4798846 YP_001032833.1 CDS prfB NC_009004.1 1519901 1520998 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(1519901..1520998) Lactococcus lactis subsp. cremoris MG1363 4799057 YP_001032834.1 CDS llmg_1548 NC_009004.1 1521136 1521723 D Family membership; phosphohydrolase 1521136..1521723 Lactococcus lactis subsp. cremoris MG1363 4798165 YP_001032835.1 CDS llmg_1549 NC_009004.1 1521871 1522041 D hypothetical protein 1521871..1522041 Lactococcus lactis subsp. cremoris MG1363 4799029 YP_001032836.1 CDS llmg_1550 NC_009004.1 1522205 1522735 D Protein of unknown function DUF402; hypothetical protein 1522205..1522735 Lactococcus lactis subsp. cremoris MG1363 4799028 YP_001032837.1 CDS fdhC NC_009004.1 1522750 1523553 R High confidence in function and specificity; formate dehydrogenase complement(1522750..1523553) Lactococcus lactis subsp. cremoris MG1363 4799027 YP_001032838.1 CDS llmg_1552 NC_009004.1 1523708 1525330 R Specificity unclear; ABC type transport system permease complement(1523708..1525330) Lactococcus lactis subsp. cremoris MG1363 4798959 YP_001032839.1 CDS llmg_1553 NC_009004.1 1525342 1526220 R Specificity unclear; ABC transporter ATP-binding protein complement(1525342..1526220) Lactococcus lactis subsp. cremoris MG1363 4799026 YP_001032840.1 CDS llmg_1554 NC_009004.1 1526416 1527066 D Homeodomain-like; Family membership; TetR family transcriptional regulator 1526416..1527066 Lactococcus lactis subsp. cremoris MG1363 4799005 YP_001032841.1 CDS llmg_1555 NC_009004.1 1527099 1528016 R Protein of unknown function DUF199; hypothetical protein complement(1527099..1528016) Lactococcus lactis subsp. cremoris MG1363 4799004 YP_001032842.1 CDS llmg_1556 NC_009004.1 1528112 1529095 R Conserved hypothetical protein CofD related, Uncharacterised protein family UPF0052; hypothetical protein complement(1528112..1529095) Lactococcus lactis subsp. cremoris MG1363 4799003 YP_001032843.1 CDS llmg_1557 NC_009004.1 1529092 1529979 R Uncharacterised P-loop ATPase UPF0042; Family membership; hypothetical protein complement(1529092..1529979) Lactococcus lactis subsp. cremoris MG1363 4799002 YP_001032844.1 CDS clsA NC_009004.1 1530044 1531489 R High confidence in function and specificity; cardiolipin synthetase complement(1530044..1531489) Lactococcus lactis subsp. cremoris MG1363 4799001 YP_001032845.1 CDS flpA NC_009004.1 1531681 1532370 R Cyclic nucleotide-binding domain; High confidence in function and specificity; FNR like protein A complement(1531681..1532370) Lactococcus lactis subsp. cremoris MG1363 4798105 YP_001032846.1 CDS llmg_1560 NC_009004.1 1532360 1532899 R Ferritin/ribonucleotide reductase-like; Conserved hypothetical protein; stress induced DNA binding protein () complement(1532360..1532899) Lactococcus lactis subsp. cremoris MG1363 4796689 YP_001032847.1 CDS llmg_1561 NC_009004.1 1533121 1534983 R High confidence in function and specificity; heavy metal-translocating P-type ATPase complement(1533121..1534983) Lactococcus lactis subsp. cremoris MG1363 4799000 YP_001032848.1 CDS llmg_1562 NC_009004.1 1535617 1536057 R hypothetical protein complement(1535617..1536057) Lactococcus lactis subsp. cremoris MG1363 4798999 YP_001032849.1 CDS llmg_1563 NC_009004.1 1536449 1537783 R Protein of unknown function DUF805; Conserved hypothetical protein; hypothetical protein complement(1536449..1537783) Lactococcus lactis subsp. cremoris MG1363 4798998 YP_001032850.1 CDS llmg_1564 NC_009004.1 1538074 1538364 D transposase helper protein for IS904; High confidence in function and specificity; hypothetical protein 1538074..1538364 Lactococcus lactis subsp. cremoris MG1363 4798997 YP_001032851.1 CDS tnp904 NC_009004.1 1538460 1539221 D Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence IS904F 1538460..1539221 Lactococcus lactis subsp. cremoris MG1363 4798996 YP_001032852.1 CDS llmg_1566 NC_009004.1 1539275 1539856 D High confidence in function and specificity; hypothetical protein 1539275..1539856 Lactococcus lactis subsp. cremoris MG1363 4797361 YP_001032853.1 CDS fruA NC_009004.1 1540757 1542661 R High confidence in function and specificity; PTS system, fructose specific IIBC components complement(1540757..1542661) Lactococcus lactis subsp. cremoris MG1363 4796624 YP_001032854.1 CDS fruC NC_009004.1 1542661 1543578 R High confidence in function and specificity; tagatose-6-phosphate kinase complement(1542661..1543578) Lactococcus lactis subsp. cremoris MG1363 4798943 YP_001032855.1 CDS fruR NC_009004.1 1543662 1544363 R Bacterial regulatory proteins, deoR family; High confidence in function and specificity; lactose transport regulator complement(1543662..1544363) Lactococcus lactis subsp. cremoris MG1363 4797790 YP_001032856.1 CDS hipO2 NC_009004.1 1544485 1545624 R High confidence in function and specificity; aminoacylase/N-acyl-L-amino acid amidohydrolase/hippurate hydrolase complement(1544485..1545624) Lactococcus lactis subsp. cremoris MG1363 4797339 YP_001032857.1 CDS mycA NC_009004.1 1545691 1547454 R in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; hypothetical protein complement(1545691..1547454) Lactococcus lactis subsp. cremoris MG1363 4798337 YP_001032858.1 CDS llmg_1573 NC_009004.1 1547624 1549468 R Hypothetical 70.0 kDa protein in dnaK 3'region; hypothetical protein complement(1547624..1549468) Lactococcus lactis subsp. cremoris MG1363 4797063 YP_001032859.1 CDS dnaK NC_009004.1 1549632 1551455 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(1549632..1551455) Lactococcus lactis subsp. cremoris MG1363 4798994 YP_001032860.1 CDS grpE NC_009004.1 1551527 1552066 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(1551527..1552066) Lactococcus lactis subsp. cremoris MG1363 4798395 YP_001032861.1 CDS hrcA NC_009004.1 1552096 1553139 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(1552096..1553139) Lactococcus lactis subsp. cremoris MG1363 4798750 YP_001032862.1 CDS llmg_1577 NC_009004.1 1553287 1553691 R hypothetical protein complement(1553287..1553691) Lactococcus lactis subsp. cremoris MG1363 4796612 YP_001032863.1 CDS dacB NC_009004.1 1553706 1554452 R High confidence in function and specificity; D-alanyl-D-alanine carboxypeptidase complement(1553706..1554452) Lactococcus lactis subsp. cremoris MG1363 4798993 YP_001032864.1 CDS gpmB NC_009004.1 1554449 1555144 R High confidence in function and specificity; phosphoglycerate mutase complement(1554449..1555144) Lactococcus lactis subsp. cremoris MG1363 4798872 YP_001032865.1 CDS llmg_1580 NC_009004.1 1555215 1555694 R hypothetical protein complement(1555215..1555694) Lactococcus lactis subsp. cremoris MG1363 4798590 YP_001032866.1 CDS llmg_1581 NC_009004.1 1555789 1557126 R Protein of unknown function DUF711; hypothetical protein complement(1555789..1557126) Lactococcus lactis subsp. cremoris MG1363 4798992 YP_001032867.1 CDS llmg_1582 NC_009004.1 1557243 1557506 R ACT domain-containing protein; hypothetical protein complement(1557243..1557506) Lactococcus lactis subsp. cremoris MG1363 4798991 YP_001032868.1 CDS llmg_1583 NC_009004.1 1557660 1558601 D Specificity unclear; prenyltransferase 1557660..1558601 Lactococcus lactis subsp. cremoris MG1363 4798990 YP_001032869.1 CDS llmg_1584 NC_009004.1 1558625 1559683 R Family membership; hypothetical protein complement(1558625..1559683) Lactococcus lactis subsp. cremoris MG1363 4798989 YP_001032870.1 CDS llmg_1585 NC_009004.1 1559761 1560348 R Similar to amidases related to nicotinamidase; Family membership; amidase complement(1559761..1560348) Lactococcus lactis subsp. cremoris MG1363 4798988 YP_001032871.1 CDS vacB1 NC_009004.1 1560360 1562819 R exoribonuclease, VacB/Rnb family; High confidence in function and specificity; exoribonuclease R complement(1560360..1562819) Lactococcus lactis subsp. cremoris MG1363 4798987 YP_001032872.1 CDS secG NC_009004.1 1563061 1563309 R Preprotein translocase SecG subunit; High confidence in function and specificity; preprotein translocase subunit SecG complement(1563061..1563309) Lactococcus lactis subsp. cremoris MG1363 4798437 YP_001032873.1 CDS trxB1 NC_009004.1 1563450 1564376 R High confidence in function and specificity; TrxB1 protein complement(1563450..1564376) Lactococcus lactis subsp. cremoris MG1363 4798271 YP_001032874.1 CDS llmg_1589 NC_009004.1 1564574 1564801 R hypothetical protein complement(1564574..1564801) Lactococcus lactis subsp. cremoris MG1363 4797152 YP_001032875.1 CDS llmg_1590 NC_009004.1 1564803 1565555 R Specificity unclear; amino-acid ABC transporter ATP-binding protein complement(1564803..1565555) Lactococcus lactis subsp. cremoris MG1363 4798986 YP_001032876.1 CDS llmg_1591 NC_009004.1 1565567 1566454 R Specificity unclear; amino-acid ABC transporter permease complement(1565567..1566454) Lactococcus lactis subsp. cremoris MG1363 4798985 YP_001032877.1 CDS llmg_1593 NC_009004.1 1566722 1567570 R Specificity unclear; amino acid ABC transporter substrate-binding protein complement(1566722..1567570) Lactococcus lactis subsp. cremoris MG1363 4798984 YP_001032878.1 CDS llmg_1594 NC_009004.1 1567714 1568289 R Region start changed from 1568256 to 1568289 (33 bases); gamma-glutamyl-diamino acid-endopeptidase complement(1567714..1568289) Lactococcus lactis subsp. cremoris MG1363 4798983 YP_001032879.1 CDS fhs NC_009004.1 1568416 1570083 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1568416..1570083) Lactococcus lactis subsp. cremoris MG1363 4798982 YP_001032880.1 CDS llmg_1596 NC_009004.1 1570244 1570570 R Protein of unknown function DUF74; hypothetical protein complement(1570244..1570570) Lactococcus lactis subsp. cremoris MG1363 4798197 YP_001032881.1 CDS llmg_1597 NC_009004.1 1570654 1571100 R Protein of unknown function DUF984; hypothetical protein complement(1570654..1571100) Lactococcus lactis subsp. cremoris MG1363 4798981 YP_001032882.1 CDS llmg_1598 NC_009004.1 1571714 1572202 D hypothetical protein 1571714..1572202 Lactococcus lactis subsp. cremoris MG1363 4798980 YP_001032883.1 CDS deoD NC_009004.1 1572439 1573143 R catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase complement(1572439..1573143) Lactococcus lactis subsp. cremoris MG1363 4798979 YP_001032884.1 CDS llmg_1600 NC_009004.1 1573214 1573483 R hypothetical protein complement(1573214..1573483) Lactococcus lactis subsp. cremoris MG1363 4798886 YP_001032885.1 CDS deoB NC_009004.1 1573541 1574776 R catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase complement(1573541..1574776) Lactococcus lactis subsp. cremoris MG1363 4798978 YP_001032886.1 CDS llmg_1602 NC_009004.1 1574963 1575793 R Similar to cell envelope-related transcriptional attenuator lytR; Conserved hypothetical protein; transcriptional regulator complement(1574963..1575793) Lactococcus lactis subsp. cremoris MG1363 4798881 YP_001032887.1 CDS tagB NC_009004.1 1575893 1577008 R teichoic acid biosynthesis protein B complement(1575893..1577008) Lactococcus lactis subsp. cremoris MG1363 4798977 YP_001032888.1 CDS tagF NC_009004.1 1576998 1578185 R CDP-glycerol:glycerophosphate glycerophosphotransferase; High confidence in function and specificity; teichoic acid biosynthesis protein F complement(1576998..1578185) Lactococcus lactis subsp. cremoris MG1363 4798736 YP_001032889.1 CDS llmg_1605 NC_009004.1 1578208 1578639 R hypothetical protein complement(1578208..1578639) Lactococcus lactis subsp. cremoris MG1363 4798746 YP_001032890.1 CDS tagD2 NC_009004.1 1578636 1579091 R High confidence in function and specificity; glycerol-3-phosphate cytidylyltransferase complement(1578636..1579091) Lactococcus lactis subsp. cremoris MG1363 4798976 YP_001032891.1 CDS llmg_1607 NC_009004.1 1579142 1580323 R hypothetical protein complement(1579142..1580323) Lactococcus lactis subsp. cremoris MG1363 4798737 YP_001032892.1 CDS llmg_1608 NC_009004.1 1580420 1581421 R Similar to xylosidases/arabinosidases; Function unclear; glycosyl hydrolases complement(1580420..1581421) Lactococcus lactis subsp. cremoris MG1363 4798975 YP_001032893.1 CDS llmg_1609 NC_009004.1 1581424 1582710 R Similar to lipolytic enzymes, G-D-S-L family; Family membership; hypothetical protein complement(1581424..1582710) Lactococcus lactis subsp. cremoris MG1363 4798695 YP_001032894.1 CDS tnp712 NC_009004.1 1584010 1585233 D Integrase, catalytic region; Specificity unclear; transposase for insertion sequence element IS712G 1584010..1585233 Lactococcus lactis subsp. cremoris MG1363 4796735 YP_001032895.1 CDS llmg_1612 NC_009004.1 1585245 1586003 D PF01695: IstB-like ATP-binding protein; Specificity unclear; transposase helper protein for IS712G 1585245..1586003 Lactococcus lactis subsp. cremoris MG1363 4797570 YP_001032896.1 CDS llmg_1613 NC_009004.1 1586044 1586841 R hypothetical protein complement(1586044..1586841) Lactococcus lactis subsp. cremoris MG1363 4798693 YP_001032897.1 CDS llmg_1614 NC_009004.1 1586856 1587236 R hypothetical protein complement(1586856..1587236) Lactococcus lactis subsp. cremoris MG1363 4798692 YP_001032898.1 CDS llmg_1615 NC_009004.1 1587246 1587899 R Family membership; acetyltransferase complement(1587246..1587899) Lactococcus lactis subsp. cremoris MG1363 4798691 YP_001032899.1 CDS ugd NC_009004.1 1587913 1589082 R High confidence in function and specificity; UDP-glucose 6-dehydrogenase complement(1587913..1589082) Lactococcus lactis subsp. cremoris MG1363 4798690 YP_001032900.1 CDS llmg_1617 NC_009004.1 1589136 1592123 R glycosyl transferase, group 2 family protein, Glycosyltransferases involved in cell wall biogenesis; Family membership; hypothetical protein complement(1589136..1592123) Lactococcus lactis subsp. cremoris MG1363 4798017 YP_001032901.1 CDS llmg_1618 NC_009004.1 1592144 1593481 R hypothetical protein complement(1592144..1593481) Lactococcus lactis subsp. cremoris MG1363 4798689 YP_001032902.1 CDS llmg_1619 NC_009004.1 1593468 1594496 R hypothetical protein complement(1593468..1594496) Lactococcus lactis subsp. cremoris MG1363 4798688 YP_001032903.1 CDS llmg_1620 NC_009004.1 1594493 1596694 R glycosyl transferase, group 2 family protein, Glycosyltransferases involved in cell wall biogenesis; Family membership; hypothetical protein complement(1594493..1596694) Lactococcus lactis subsp. cremoris MG1363 4798687 YP_001032904.1 CDS llmg_1621 NC_009004.1 1596691 1598169 R glycosyl transferase, group 2 family protein, Glycosyltransferases involved in cell wall biogenesi; Family membership; hypothetical protein complement(1596691..1598169) Lactococcus lactis subsp. cremoris MG1363 4798686 YP_001032905.1 CDS tagG NC_009004.1 1598186 1598992 R High confidence in function and specificity; teichoic acid ABC transporter permease complement(1598186..1598992) Lactococcus lactis subsp. cremoris MG1363 4798685 YP_001032906.1 CDS tagH NC_009004.1 1599003 1600433 R High confidence in function and specificity; teichoic acid export ATP-binding protein tagH complement(1599003..1600433) Lactococcus lactis subsp. cremoris MG1363 4798747 YP_001032907.1 CDS tagL NC_009004.1 1600496 1601404 R High confidence in function and specificity; exopolysaccharide biosynthesis protein complement(1600496..1601404) Lactococcus lactis subsp. cremoris MG1363 4798757 YP_001032908.1 CDS llmg_1625 NC_009004.1 1601728 1602447 R Conserved hypothetical protein; hypothetical protein complement(1601728..1602447) Lactococcus lactis subsp. cremoris MG1363 4798759 YP_001032909.1 CDS rmaH NC_009004.1 1603984 1604448 R Specificity unclear; MarR family transcriptional regulator complement(1603984..1604448) Lactococcus lactis subsp. cremoris MG1363 4797429 YP_001032910.1 CDS llmg_1628 NC_009004.1 1604605 1605246 R Conserved hypothetical protein; hypothetical protein complement(1604605..1605246) Lactococcus lactis subsp. cremoris MG1363 4798040 YP_001032911.1 CDS llmg_1629 NC_009004.1 1605419 1606156 R methyltransferase, UbiE/COQ5 family; Family membership; methyltransferase complement(1605419..1606156) Lactococcus lactis subsp. cremoris MG1363 4798683 YP_001032912.1 CDS llmg_1630 NC_009004.1 1606380 1606565 R hypothetical protein complement(1606380..1606565) Lactococcus lactis subsp. cremoris MG1363 4798682 YP_001032913.1 CDS gyrB NC_009004.1 1606663 1608618 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(1606663..1608618) Lactococcus lactis subsp. cremoris MG1363 4798681 YP_001032914.1 CDS llmg_1632 NC_009004.1 1608772 1609419 R Haloacid dehalogenase-like hydrolase; High confidence in function and specificity; hydrolase complement(1608772..1609419) Lactococcus lactis subsp. cremoris MG1363 4797544 YP_001032915.1 CDS llmg_1633 NC_009004.1 1609485 1610330 R Similar to predicted ring-cleavage extradiol dioxygenase; Family membership; hypothetical protein complement(1609485..1610330) Lactococcus lactis subsp. cremoris MG1363 4798680 YP_001032916.1 CDS llmg_1634 NC_009004.1 1610468 1612048 R Similar to ABC type transport system permease; Conserved hypothetical protein; hypothetical protein complement(1610468..1612048) Lactococcus lactis subsp. cremoris MG1363 4798679 YP_001032917.1 CDS llmg_1635 NC_009004.1 1612029 1612793 R Specificity unclear; ABC transporter ATP-binding protein complement(1612029..1612793) Lactococcus lactis subsp. cremoris MG1363 4798678 YP_001032918.1 CDS llmg_1636 NC_009004.1 1612916 1613815 R TIGRFAM 2A78: Carboxylate/Amino Acid/Amine Transporter; Conserved hypothetical protein; permease complement(1612916..1613815) Lactococcus lactis subsp. cremoris MG1363 4798677 YP_001032919.1 CDS mleP NC_009004.1 1614001 1615278 R High confidence in function and specificity; malate transporter complement(1614001..1615278) Lactococcus lactis subsp. cremoris MG1363 4798676 YP_001032920.1 CDS mleS NC_009004.1 1615293 1616915 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1615293..1616915) Lactococcus lactis subsp. cremoris MG1363 4798616 YP_001032921.1 CDS llmg_1639 NC_009004.1 1617330 1618880 R Similar to lincosamides and streptogramins A transporter Lsa; Specificity unclear; ABC transporter ATP-binding protein complement(1617330..1618880) Lactococcus lactis subsp. cremoris MG1363 4797155 YP_001032922.1 CDS llmg_1640 NC_009004.1 1618991 1619152 R hypothetical protein complement(1618991..1619152) Lactococcus lactis subsp. cremoris MG1363 4798675 YP_001032923.1 CDS butA NC_009004.1 1619425 1620186 R High confidence in function and specificity; acetoin reductase complement(1619425..1620186) Lactococcus lactis subsp. cremoris MG1363 4798674 YP_001032924.1 CDS butB NC_009004.1 1620222 1621202 R High confidence in function and specificity; 2,3-butanediol dehydrogenase complement(1620222..1621202) Lactococcus lactis subsp. cremoris MG1363 4797719 YP_001032925.1 CDS rodA NC_009004.1 1621500 1622744 R Cell cycle protein; High confidence in function and specificity; rod shape-determining protein RodA complement(1621500..1622744) Lactococcus lactis subsp. cremoris MG1363 4797722 YP_001032926.1 CDS llmg_1644 NC_009004.1 1622956 1623561 R Conserved hypothetical protein; hypothetical protein complement(1622956..1623561) Lactococcus lactis subsp. cremoris MG1363 4797296 YP_001032927.1 CDS llmg_1645 NC_009004.1 1623558 1624028 R polyribonucleotide nucleotidyltransferase, 30S ribosomal protein S1; Function unclear; general stress protein GSP13 complement(1623558..1624028) Lactococcus lactis subsp. cremoris MG1363 4798673 YP_001032928.1 CDS ppiB NC_009004.1 1623991 1624581 R High confidence in function and specificity; peptidyl-prolyl cis-trans isomerase complement(1623991..1624581) Lactococcus lactis subsp. cremoris MG1363 4798672 YP_001032929.1 CDS llmg_1647 NC_009004.1 1624680 1625486 R Cof-subfamily: Cof-like hydrolase, Peptidyl-prolyl cis-trans isomerase, cyclophilin type; Family membership; hydrolase complement(1624680..1625486) Lactococcus lactis subsp. cremoris MG1363 4796924 YP_001032930.1 CDS llrD NC_009004.1 1625557 1626186 R Response regulator receiver domain; High confidence in function and specificity; two-component system regulator llrD complement(1625557..1626186) Lactococcus lactis subsp. cremoris MG1363 4798671 YP_001032931.1 CDS kinD NC_009004.1 1626214 1627212 R Histidine kinase; High confidence in function and specificity; sensor protein kinase kinD complement(1626214..1627212) Lactococcus lactis subsp. cremoris MG1363 4796745 YP_001032932.1 CDS llmg_1650 NC_009004.1 1627209 1627784 R Region start changed from 1627838 to 1627784 (-54 bases); hypothetical protein complement(1627209..1627784) Lactococcus lactis subsp. cremoris MG1363 4797122 YP_001032933.1 CDS llmg_1651 NC_009004.1 1628174 1628272 R hypothetical protein complement(1628174..1628272) Lactococcus lactis subsp. cremoris MG1363 4798670 YP_001032934.1 CDS llmg_1652 NC_009004.1 1628988 1629821 R Similar to predicted ring-cleavage extradiol dioxygenases; hypothetical protein complement(1628988..1629821) Lactococcus lactis subsp. cremoris MG1363 4798669 YP_001032935.1 CDS llmg_1653 NC_009004.1 1630153 1631604 R PF05257.3: CHAP domain; hypothetical protein complement(1630153..1631604) Lactococcus lactis subsp. cremoris MG1363 4798668 YP_001032936.1 CDS tnp981 NC_009004.1 1631663 1632502 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981M complement(1631663..1632502) Lactococcus lactis subsp. cremoris MG1363 4798667 YP_001032937.1 CDS llmg_1655 NC_009004.1 1632514 1632774 R transposase helper protein for IS981; High confidence in function and specificity; hypothetical protein complement(1632514..1632774) Lactococcus lactis subsp. cremoris MG1363 4797923 YP_001032938.1 CDS llmg_1656 NC_009004.1 1632954 1633292 D hypothetical protein 1632954..1633292 Lactococcus lactis subsp. cremoris MG1363 4798666 YP_001032939.1 CDS xerD NC_009004.1 1633481 1634455 R Similar to phage integrases; High confidence in function and specificity; integrase/recombinase complement(1633481..1634455) Lactococcus lactis subsp. cremoris MG1363 4798665 YP_001032940.1 CDS llmg_1658 NC_009004.1 1634590 1634922 R metal-sulfur cluster biosynthetic enzyme; hypothetical protein complement(1634590..1634922) Lactococcus lactis subsp. cremoris MG1363 4797890 YP_001032941.1 CDS llmg_1659 NC_009004.1 1635111 1637510 R Similar to phage infection protein pip; hypothetical protein complement(1635111..1637510) Lactococcus lactis subsp. cremoris MG1363 4798960 YP_001032942.1 CDS llmg_1660 NC_009004.1 1637672 1638205 D Family membership; TetR family transcriptional regulator 1637672..1638205 Lactococcus lactis subsp. cremoris MG1363 4798961 YP_001032943.1 CDS hslB NC_009004.1 1638267 1638572 R Histone-like bacterial DNA-binding protein; High confidence in function and specificity; HU-like DNA-binding protein complement(1638267..1638572) Lactococcus lactis subsp. cremoris MG1363 4798962 YP_001032944.1 CDS uspA NC_009004.1 1638797 1639222 R Universal stress protein family; High confidence in function and specificity; universal stress protein A complement(1638797..1639222) Lactococcus lactis subsp. cremoris MG1363 4796666 YP_001032945.1 CDS llmg_1663 NC_009004.1 1639477 1639632 D hypothetical protein 1639477..1639632 Lactococcus lactis subsp. cremoris MG1363 4798293 YP_001032946.1 CDS pnuC2 NC_009004.1 1639775 1640500 R High confidence in function and specificity; nicotinamide mononucleotide transporter complement(1639775..1640500) Lactococcus lactis subsp. cremoris MG1363 4798963 YP_001032947.1 CDS llmg_1665 NC_009004.1 1640773 1641018 D hypothetical protein 1640773..1641018 Lactococcus lactis subsp. cremoris MG1363 4799056 YP_001032948.1 CDS llmg_1666 NC_009004.1 1641081 1641638 R Conserved hypothetical protein; hypothetical protein complement(1641081..1641638) Lactococcus lactis subsp. cremoris MG1363 4798964 YP_001032949.1 CDS llmg_1667 NC_009004.1 1641869 1643197 R Glycosyl transferase, family 2, Glycosyltransferases, probably involved in cell wall biogenesis; Specificity unclear; glycosyltransferase complement(1641869..1643197) Lactococcus lactis subsp. cremoris MG1363 4798965 YP_001032950.1 CDS llmg_1668 NC_009004.1 1643190 1643381 R hypothetical protein complement(1643190..1643381) Lactococcus lactis subsp. cremoris MG1363 4798966 YP_001032951.1 CDS llmg_1669 NC_009004.1 1643957 1644418 D GCN5-related N-acetyltransferase; acetyltransferase 1643957..1644418 Lactococcus lactis subsp. cremoris MG1363 4798967 YP_001032952.1 CDS llmg_1670 NC_009004.1 1644756 1645172 D Conserved hypothetical protein; ketosteroid isomerase 1644756..1645172 Lactococcus lactis subsp. cremoris MG1363 4798968 YP_001032953.1 CDS rplS NC_009004.1 1645348 1645692 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1645348..1645692) Lactococcus lactis subsp. cremoris MG1363 4798969 YP_001032954.1 CDS llmg_1672 NC_009004.1 1645852 1646526 R Similar to GTP pyrophosphokinases; High confidence in function and specificity; hypothetical protein complement(1645852..1646526) Lactococcus lactis subsp. cremoris MG1363 4797854 YP_001032955.1 CDS mleR NC_009004.1 1648077 1648964 R High confidence in function and specificity; malolactic fermentation system transcription activator complement(1648077..1648964) Lactococcus lactis subsp. cremoris MG1363 4798459 YP_001032956.1 CDS llmg_1675 NC_009004.1 1649325 1649987 R Specificity unclear; ABC transporter ATP-binding protein complement(1649325..1649987) Lactococcus lactis subsp. cremoris MG1363 4797524 YP_001032957.1 CDS llmg_1676 NC_009004.1 1650095 1651612 R Protein of unknown function DUF214; Function unclear; ABC transporter permease complement(1650095..1651612) Lactococcus lactis subsp. cremoris MG1363 4798971 YP_001032958.1 CDS llmg_1677 NC_009004.1 1651763 1652047 R hypothetical protein complement(1651763..1652047) Lactococcus lactis subsp. cremoris MG1363 4798972 YP_001032959.1 CDS mraY NC_009004.1 1652246 1653235 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1652246..1653235) Lactococcus lactis subsp. cremoris MG1363 4798973 YP_001032960.1 CDS pbpX NC_009004.1 1653310 1655607 R High confidence in function and specificity; penicillin-binding protein complement(1653310..1655607) Lactococcus lactis subsp. cremoris MG1363 4797575 YP_001032961.1 CDS ftsL NC_009004.1 1655604 1655984 R Conserved hypothetical protein; cell division protein complement(1655604..1655984) Lactococcus lactis subsp. cremoris MG1363 4798150 YP_001032962.1 CDS mraW NC_009004.1 1656140 1657093 R High confidence in function and specificity; S-adenosyl-methyltransferase MraW complement(1656140..1657093) Lactococcus lactis subsp. cremoris MG1363 4798341 YP_001032963.1 CDS llmg_1682 NC_009004.1 1657324 1658250 R Protein of unknown function DUF805; Conserved hypothetical protein; hypothetical protein complement(1657324..1658250) Lactococcus lactis subsp. cremoris MG1363 4796863 YP_001032964.1 CDS llmg_1683 NC_009004.1 1658272 1658793 R Protein of unknown function DUF805; Conserved hypothetical protein; hypothetical protein complement(1658272..1658793) Lactococcus lactis subsp. cremoris MG1363 4798974 YP_001032965.1 CDS llmg_1684 NC_009004.1 1658888 1659454 R Protein of unknown function DUF1211; Conserved hypothetical protein; hypothetical protein complement(1658888..1659454) Lactococcus lactis subsp. cremoris MG1363 4799017 YP_001032966.1 CDS recN NC_009004.1 1660156 1661823 R Recombination protein N; High confidence in function and specificity; DNA repair protein recN complement(1660156..1661823) Lactococcus lactis subsp. cremoris MG1363 4798661 YP_001032967.1 CDS ahrC NC_009004.1 1662003 1662449 R High confidence in function and specificity; arginine transcriptional regulator complement(1662003..1662449) Lactococcus lactis subsp. cremoris MG1363 4798230 YP_001032968.1 CDS llmg_1687 NC_009004.1 1662446 1663252 R Similar to tly, Hemolysin A, Similar to rRNA methylases; hypothetical protein complement(1662446..1663252) Lactococcus lactis subsp. cremoris MG1363 4796703 YP_001032969.1 CDS llmg_1688 NC_009004.1 1663328 1663828 R GCN5-related N-acetyltransferase; Family membership; acetyltransferase complement(1663328..1663828) Lactococcus lactis subsp. cremoris MG1363 4796580 YP_001032970.1 CDS ispA NC_009004.1 1663829 1664734 R geranyltranstransferase complement(1663829..1664734) Lactococcus lactis subsp. cremoris MG1363 4797409 YP_001032971.1 CDS xseB NC_009004.1 1666225 1666464 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1666225..1666464) Lactococcus lactis subsp. cremoris MG1363 4798591 YP_001032972.1 CDS xseA NC_009004.1 1666467 1667720 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1666467..1667720) Lactococcus lactis subsp. cremoris MG1363 4797853 YP_001032973.1 CDS folD NC_009004.1 1667891 1668748 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(1667891..1668748) Lactococcus lactis subsp. cremoris MG1363 4797860 YP_001032974.1 CDS copB NC_009004.1 1668937 1670979 D High confidence in function and specificity; copper-potassium transporting ATPase B 1668937..1670979 Lactococcus lactis subsp. cremoris MG1363 4798056 YP_001032975.1 CDS llmg_1695 NC_009004.1 1671055 1671336 R hypothetical protein complement(1671055..1671336) Lactococcus lactis subsp. cremoris MG1363 4798804 YP_001032976.1 CDS llmg_1698 NC_009004.1 1672592 1674109 R hypothetical protein complement(1672592..1674109) Lactococcus lactis subsp. cremoris MG1363 4797878 YP_001032977.1 CDS choS NC_009004.1 1674398 1675900 R High confidence in function and specificity; choline ABC transporter permease and substrate binding protein complement(1674398..1675900) Lactococcus lactis subsp. cremoris MG1363 4797983 YP_001032978.1 CDS choQ NC_009004.1 1675897 1676814 R High confidence in function and specificity; choline ABC transporter ATP binding protein complement(1675897..1676814) Lactococcus lactis subsp. cremoris MG1363 4798179 YP_001032979.1 CDS llmg_1701 NC_009004.1 1676817 1676960 D hypothetical protein 1676817..1676960 Lactococcus lactis subsp. cremoris MG1363 4796962 YP_001032980.1 CDS gshR NC_009004.1 1676943 1678250 R High confidence in function and specificity; glutathione reductase complement(1676943..1678250) Lactococcus lactis subsp. cremoris MG1363 4798320 YP_001032981.1 CDS llmg_1703 NC_009004.1 1678389 1678817 R Similar to regulatory protein spx; Family membership; hypothetical protein complement(1678389..1678817) Lactococcus lactis subsp. cremoris MG1363 4798755 YP_001032982.1 CDS alr NC_009004.1 1678978 1680081 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1678978..1680081) Lactococcus lactis subsp. cremoris MG1363 4796695 YP_001032983.1 CDS acpS NC_009004.1 1680125 1680484 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1680125..1680484) Lactococcus lactis subsp. cremoris MG1363 4797682 YP_001032984.1 CDS pepV NC_009004.1 1680613 1682031 R divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV complement(1680613..1682031) Lactococcus lactis subsp. cremoris MG1363 4798910 YP_001032985.1 CDS llmg_1707 NC_009004.1 1682785 1683171 D Conserved hypothetical protein; glycosyltransferase 1682785..1683171 Lactococcus lactis subsp. cremoris MG1363 4796786 YP_001032986.1 CDS llmg_1708 NC_009004.1 1683885 1685078 R Similar to Lipopolysaccharide 1,2- glucosyltransferases; Family membership; glycosyltransferase complement(1683885..1685078) Lactococcus lactis subsp. cremoris MG1363 4797980 YP_001032987.1 CDS maa2 NC_009004.1 1685283 1685765 R High confidence in function and specificity; maltose O-acetyltransferase complement(1685283..1685765) Lactococcus lactis subsp. cremoris MG1363 4798454 YP_001032988.1 CDS llmg_1710 NC_009004.1 1685949 1686839 R Glycosyltransferases involved in cell wall biogenesis; Family membership; glycosyltransferase complement(1685949..1686839) Lactococcus lactis subsp. cremoris MG1363 4797167 YP_001032989.1 CDS tnp981 NC_009004.1 1688183 1689022 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981N complement(1688183..1689022) Lactococcus lactis subsp. cremoris MG1363 4797848 YP_001032990.1 CDS llmg_1714 NC_009004.1 1689034 1689294 R transposase helper protein for IS981; Specificity unclear; hypothetical protein complement(1689034..1689294) Lactococcus lactis subsp. cremoris MG1363 4797922 YP_001032991.1 CDS llmg_1715 NC_009004.1 1689454 1689744 D transposase helper protein for IS904; hypothetical protein 1689454..1689744 Lactococcus lactis subsp. cremoris MG1363 4797403 YP_001032992.1 CDS tnp904 NC_009004.1 1689840 1690601 D Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence IS904G 1689840..1690601 Lactococcus lactis subsp. cremoris MG1363 4797406 YP_001032993.1 CDS mutY NC_009004.1 1691590 1692750 R High confidence in function and specificity; A/G-specific adenine glycosylase complement(1691590..1692750) Lactococcus lactis subsp. cremoris MG1363 4796733 YP_001032994.1 CDS uvrC NC_009004.1 1692848 1694857 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(1692848..1694857) Lactococcus lactis subsp. cremoris MG1363 4796774 YP_001032995.1 CDS pnuC1 NC_009004.1 1694953 1695666 R High confidence in function and specificity; PnuC1 protein complement(1694953..1695666) Lactococcus lactis subsp. cremoris MG1363 4797324 YP_001032996.1 CDS udp NC_009004.1 1695684 1696400 R High confidence in function and specificity; uridine phosphorylase complement(1695684..1696400) Lactococcus lactis subsp. cremoris MG1363 4799058 YP_001032997.1 CDS llmg_1723 NC_009004.1 1698612 1700063 R Conserved hypothetical protein; hypothetical protein complement(1698612..1700063) Lactococcus lactis subsp. cremoris MG1363 4796710 YP_001032998.1 CDS rpsA NC_009004.1 1700259 1701485 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(1700259..1701485) Lactococcus lactis subsp. cremoris MG1363 4798321 YP_001032999.1 CDS mnmA NC_009004.1 1701740 1702894 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1701740..1702894) Lactococcus lactis subsp. cremoris MG1363 4799019 YP_001033000.1 CDS llmg_1726 NC_009004.1 1703183 1703968 D High confidence in function and specificity; galactose-1-phosphate uridylyltransferase 1703183..1703968 Lactococcus lactis subsp. cremoris MG1363 4797445 YP_001033001.1 CDS llmg_1727 NC_009004.1 1704039 1706690 D Conserved hypothetical protein; ABC transporter permease 1704039..1706690 Lactococcus lactis subsp. cremoris MG1363 4798319 YP_001033002.1 CDS llmg_1728 NC_009004.1 1706680 1706826 D hypothetical protein 1706680..1706826 Lactococcus lactis subsp. cremoris MG1363 4797396 YP_001033003.1 CDS copA NC_009004.1 1706892 1709054 R High confidence in function and specificity; copper/potassium-transporting ATPase complement(1706892..1709054) Lactococcus lactis subsp. cremoris MG1363 4797389 YP_001033004.1 CDS merP NC_009004.1 1709241 1709441 R TIGR00003: copper ion binding protein; High confidence in function and specificity; mercuric reductase complement(1709241..1709441) Lactococcus lactis subsp. cremoris MG1363 4798803 YP_001033005.1 CDS copR NC_009004.1 1709460 1709915 R High confidence in function and specificity; transcriptional regulator complement(1709460..1709915) Lactococcus lactis subsp. cremoris MG1363 4798331 YP_001033006.1 CDS sdaA NC_009004.1 1710037 1710900 R High confidence in function and specificity; L-serine dehydratase alpha subunit complement(1710037..1710900) Lactococcus lactis subsp. cremoris MG1363 4798808 YP_001033007.1 CDS sdaB NC_009004.1 1710920 1711591 R High confidence in function and specificity; L-serine dehydratase beta subunit complement(1710920..1711591) Lactococcus lactis subsp. cremoris MG1363 4798927 YP_001033008.1 CDS noxB NC_009004.1 1711705 1713708 R High confidence in function and specificity; NADH dehydrogenase complement(1711705..1713708) Lactococcus lactis subsp. cremoris MG1363 4798272 YP_001033009.1 CDS noxA NC_009004.1 1713852 1715111 R High confidence in function and specificity; NADH dehydrogenase complement(1713852..1715111) Lactococcus lactis subsp. cremoris MG1363 4797065 YP_001033010.1 CDS llmg_1736 NC_009004.1 1715242 1715604 R hypothetical protein complement(1715242..1715604) Lactococcus lactis subsp. cremoris MG1363 4799101 YP_001033011.1 CDS cpo NC_009004.1 1715764 1716567 R High confidence in function and specificity; non-heme chloride peroxidase complement(1715764..1716567) Lactococcus lactis subsp. cremoris MG1363 4797988 YP_001033012.1 CDS llmg_1738 NC_009004.1 1716819 1718180 R High confidence in function and specificity; beta-glucosidase complement(1716819..1718180) Lactococcus lactis subsp. cremoris MG1363 4798816 YP_001033013.1 CDS llmg_1740 NC_009004.1 1720098 1720853 R LacI-family regulatory protein; Family membership; HTH-type transcriptional regulator complement(1720098..1720853) Lactococcus lactis subsp. cremoris MG1363 4797425 YP_001033014.1 CDS leuS NC_009004.1 1721185 1723674 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(1721185..1723674) Lactococcus lactis subsp. cremoris MG1363 4797994 YP_001033015.1 CDS llmg_1742 NC_009004.1 1723745 1724416 R contains Fis-type Helix-turn-helix domain; Conserved hypothetical protein; regulator complement(1723745..1724416) Lactococcus lactis subsp. cremoris MG1363 4796671 YP_001033016.1 CDS prsA NC_009004.1 1724489 1725463 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1724489..1725463) Lactococcus lactis subsp. cremoris MG1363 4798038 YP_001033017.1 CDS ftsY NC_009004.1 1725640 1727019 R High confidence in function and specificity; signal recognition particle-docking protein complement(1725640..1727019) Lactococcus lactis subsp. cremoris MG1363 4798494 YP_001033018.1 CDS llmg_1745 NC_009004.1 1727081 1727632 R hypothetical protein complement(1727081..1727632) Lactococcus lactis subsp. cremoris MG1363 4798651 YP_001033019.1 CDS llmg_1746 NC_009004.1 1727642 1728451 R Cof-subfamily: Cof-like hydrolase; Conserved hypothetical protein; hydrolase complement(1727642..1728451) Lactococcus lactis subsp. cremoris MG1363 4797395 YP_001033020.1 CDS llmg_1747 NC_009004.1 1728858 1730168 D Family membership; amino acid permease 1728858..1730168 Lactococcus lactis subsp. cremoris MG1363 4797618 YP_001033021.1 CDS llmg_1748 NC_009004.1 1730218 1730979 R Conserved hypothetical protein; hypothetical protein complement(1730218..1730979) Lactococcus lactis subsp. cremoris MG1363 4797380 YP_001033022.1 CDS llmg_1749 NC_009004.1 1730976 1732094 R Conserved hypothetical protein; hypothetical protein complement(1730976..1732094) Lactococcus lactis subsp. cremoris MG1363 4797995 YP_001033023.1 CDS llmg_1750 NC_009004.1 1732185 1732595 R hypothetical protein complement(1732185..1732595) Lactococcus lactis subsp. cremoris MG1363 4797982 YP_001033024.1 CDS llmg_1751 NC_009004.1 1732686 1734854 R Conserved hypothetical protein; alkaline phosphatase complement(1732686..1734854) Lactococcus lactis subsp. cremoris MG1363 4797977 YP_001033025.1 CDS smc NC_009004.1 1735096 1738620 R High confidence in function and specificity; chromosome segregation protein smc complement(1735096..1738620) Lactococcus lactis subsp. cremoris MG1363 4797410 YP_001033026.1 CDS rnc NC_009004.1 1738610 1739305 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1738610..1739305) Lactococcus lactis subsp. cremoris MG1363 4797743 YP_001033027.1 CDS argF NC_009004.1 1739480 1740481 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(1739480..1740481) Lactococcus lactis subsp. cremoris MG1363 4798050 YP_001033028.1 CDS argB NC_009004.1 1740509 1741360 R catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase complement(1740509..1741360) Lactococcus lactis subsp. cremoris MG1363 4798089 YP_001033029.1 CDS argD NC_009004.1 1741357 1742490 R High confidence in function and specificity; acetylornithine aminotransferase complement(1741357..1742490) Lactococcus lactis subsp. cremoris MG1363 4797969 YP_001033030.1 CDS argJ NC_009004.1 1742503 1743693 R bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase complement(1742503..1743693) Lactococcus lactis subsp. cremoris MG1363 4798473 YP_001033031.1 CDS argC NC_009004.1 1743705 1744727 R catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase complement(1743705..1744727) Lactococcus lactis subsp. cremoris MG1363 4799150 YP_001033032.1 CDS llmg_1759 NC_009004.1 1744868 1745500 R Family membership; NADH-flavin reductase complement(1744868..1745500) Lactococcus lactis subsp. cremoris MG1363 4798016 YP_001033033.1 CDS llmg_1760 NC_009004.1 1745604 1746113 R Protein of unknown function DUF988; hypothetical protein complement(1745604..1746113) Lactococcus lactis subsp. cremoris MG1363 4797382 YP_001033034.1 CDS llmg_1761 NC_009004.1 1746125 1746241 D hypothetical protein 1746125..1746241 Lactococcus lactis subsp. cremoris MG1363 4797401 YP_001033035.1 CDS fabG NC_009004.1 1746516 1747247 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(1746516..1747247) Lactococcus lactis subsp. cremoris MG1363 4797984 YP_001033036.1 CDS llmg_1763 NC_009004.1 1747264 1747503 R hypothetical protein complement(1747264..1747503) Lactococcus lactis subsp. cremoris MG1363 4797398 YP_001033037.1 CDS metS NC_009004.1 1748021 1750009 R High confidence in function and specificity; MetS protein complement(1748021..1750009) Lactococcus lactis subsp. cremoris MG1363 4797402 YP_001033038.1 CDS exoA NC_009004.1 1750191 1751048 D exodeoxyribonuclease A; High confidence in function and specificity; 3'-exo-deoxyribonuclease 1750191..1751048 Lactococcus lactis subsp. cremoris MG1363 4798900 YP_001033039.1 CDS llmg_1766 NC_009004.1 1751137 1751694 D GCN5-related N-acetyltransferase; High confidence in function and specificity; acetyltransferase 1751137..1751694 Lactococcus lactis subsp. cremoris MG1363 4797415 YP_001033040.1 CDS rdrA NC_009004.1 1751946 1752530 D High confidence in function and specificity; DeoR family transcriptional regulator 1751946..1752530 Lactococcus lactis subsp. cremoris MG1363 4797992 YP_001033041.1 CDS llmg_1768 NC_009004.1 1752697 1753047 R Similar to regulatory protein spx; Family membership; hypothetical protein complement(1752697..1753047) Lactococcus lactis subsp. cremoris MG1363 4796590 YP_001033042.1 CDS llmg_1769 NC_009004.1 1753123 1753377 R Protein of unknown function DUF156; hypothetical protein complement(1753123..1753377) Lactococcus lactis subsp. cremoris MG1363 4797408 YP_001033043.1 CDS noxC NC_009004.1 1753404 1755047 R High confidence in function and specificity; NADH oxidase complement(1753404..1755047) Lactococcus lactis subsp. cremoris MG1363 4798111 YP_001033044.1 CDS llmg_1771 NC_009004.1 1755044 1755352 R Contains rhodanese-like domain; Conserved hypothetical protein; rhodanese-related sulfurtransferase complement(1755044..1755352) Lactococcus lactis subsp. cremoris MG1363 4797039 YP_001033045.1 CDS llmg_1772 NC_009004.1 1755363 1755740 R Contains Rhodanese-like domain; Conserved hypothetical protein; rhodanese-related sulfurtransferase complement(1755363..1755740) Lactococcus lactis subsp. cremoris MG1363 4797390 YP_001033046.1 CDS llmg_1773 NC_009004.1 1755797 1756036 R CsbD-like protein; hypothetical protein complement(1755797..1756036) Lactococcus lactis subsp. cremoris MG1363 4796755 YP_001033047.1 CDS llmg_1774 NC_009004.1 1756038 1756130 R hypothetical protein complement(1756038..1756130) Lactococcus lactis subsp. cremoris MG1363 4797400 YP_001033048.1 CDS cysK NC_009004.1 1756264 1757184 R cysteine synthase; High confidence in function and specificity; O-acetylserine sulfhydrylase complement(1756264..1757184) Lactococcus lactis subsp. cremoris MG1363 4797411 YP_001033049.1 CDS metC NC_009004.1 1757399 1758541 R catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine; cystathionine gamma-synthase complement(1757399..1758541) Lactococcus lactis subsp. cremoris MG1363 4798866 YP_001033050.1 CDS accA NC_009004.1 1758672 1759466 R High confidence in function and specificity; AccA protein complement(1758672..1759466) Lactococcus lactis subsp. cremoris MG1363 4798868 YP_001033051.1 CDS accD NC_009004.1 1759459 1760325 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(1759459..1760325) Lactococcus lactis subsp. cremoris MG1363 4796842 YP_001033052.1 CDS accC NC_009004.1 1760411 1761778 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit complement(1760411..1761778) Lactococcus lactis subsp. cremoris MG1363 4798865 YP_001033053.1 CDS llmg_1780 NC_009004.1 1761771 1761953 R hypothetical protein complement(1761771..1761953) Lactococcus lactis subsp. cremoris MG1363 4798855 YP_001033054.1 CDS fabZ NC_009004.1 1762172 1762606 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(1762172..1762606) Lactococcus lactis subsp. cremoris MG1363 4798455 YP_001033055.1 CDS accB NC_009004.1 1762733 1763200 R composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(1762733..1763200) Lactococcus lactis subsp. cremoris MG1363 4797581 YP_001033056.1 CDS fabF NC_009004.1 1763207 1764436 R High confidence in function and specificity; 3-oxoacyl-ACP synthase complement(1763207..1764436) Lactococcus lactis subsp. cremoris MG1363 4796577 YP_001033057.1 CDS fabG NC_009004.1 1764477 1765208 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(1764477..1765208) Lactococcus lactis subsp. cremoris MG1363 4799130 YP_001033058.1 CDS fabD NC_009004.1 1765337 1766257 R High confidence in function and specificity; malonyl CoA-acyl carrier protein transacylase complement(1765337..1766257) Lactococcus lactis subsp. cremoris MG1363 4796708 YP_001033059.1 CDS acpP NC_009004.1 1766543 1766764 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1766543..1766764) Lactococcus lactis subsp. cremoris MG1363 4797480 YP_001033060.1 CDS fabH NC_009004.1 1766945 1767922 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1766945..1767922) Lactococcus lactis subsp. cremoris MG1363 4798894 YP_001033061.1 CDS rmaG NC_009004.1 1767922 1768362 R High confidence in function and specificity; MarR family transcriptional regulator complement(1767922..1768362) Lactococcus lactis subsp. cremoris MG1363 4796594 YP_001033062.1 CDS pmi NC_009004.1 1768769 1769716 R High confidence in function and specificity; mannose-6-phosphate isomerase complement(1768769..1769716) Lactococcus lactis subsp. cremoris MG1363 4798063 YP_001033063.1 CDS llmg_1790 NC_009004.1 1769704 1769883 D hypothetical protein 1769704..1769883 Lactococcus lactis subsp. cremoris MG1363 4797801 YP_001033064.1 CDS rbfA NC_009004.1 1769892 1770251 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1769892..1770251) Lactococcus lactis subsp. cremoris MG1363 4797384 YP_001033065.1 CDS infB NC_009004.1 1770497 1773349 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1770497..1773349) Lactococcus lactis subsp. cremoris MG1363 4796800 YP_001033066.1 CDS llmg_1793 NC_009004.1 1773370 1773675 R Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Conserved hypothetical protein; hypothetical protein complement(1773370..1773675) Lactococcus lactis subsp. cremoris MG1363 4797652 YP_001033067.1 CDS llmg_1794 NC_009004.1 1773678 1774004 R Protein of unknown function DUF448., Predicted nucleic-acid-binding protein implicated in transcription termination; hypothetical protein complement(1773678..1774004) Lactococcus lactis subsp. cremoris MG1363 4797405 YP_001033068.1 CDS nusA NC_009004.1 1774170 1775318 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1774170..1775318) Lactococcus lactis subsp. cremoris MG1363 4797407 YP_001033069.1 CDS llmg_1797 NC_009004.1 1775486 1775959 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(1775486..1775959) Lactococcus lactis subsp. cremoris MG1363 4796861 YP_001033070.1 CDS lrgA NC_009004.1 1776233 1776637 D export of murein hydrolases; Conserved hypothetical protein; LrgA family protein 1776233..1776637 Lactococcus lactis subsp. cremoris MG1363 4797999 YP_001033071.1 CDS lrgB NC_009004.1 1776656 1777354 D effector of murein hydrolase; Conserved hypothetical protein; LrgB family protein 1776656..1777354 Lactococcus lactis subsp. cremoris MG1363 4797617 YP_001033072.1 CDS llmg_1800 NC_009004.1 1777419 1778129 R Conserved hypothetical protein; hypothetical protein complement(1777419..1778129) Lactococcus lactis subsp. cremoris MG1363 4796677 YP_001033073.1 CDS srtC NC_009004.1 1778143 1779432 R High confidence in function and specificity; sortase complement(1778143..1779432) Lactococcus lactis subsp. cremoris MG1363 4797391 YP_001033074.1 CDS llmg_1802 NC_009004.1 1779483 1781306 R Contains Cna B-type domain (PF05738.2); hypothetical protein complement(1779483..1781306) Lactococcus lactis subsp. cremoris MG1363 4798581 YP_001033075.1 CDS llmg_1803 NC_009004.1 1781422 1784949 R Surface protein from Gram-positive cocci, anchor region; Family membership; hypothetical protein complement(1781422..1784949) Lactococcus lactis subsp. cremoris MG1363 4797393 YP_001033076.1 CDS llmg_1804 NC_009004.1 1785382 1786230 R Transcriptional regulator Rgg/GadR/MutR family; Family membership; Rgg family transcriptional regulator complement(1785382..1786230) Lactococcus lactis subsp. cremoris MG1363 4797616 YP_001033077.1 CDS engA NC_009004.1 1786335 1787645 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1786335..1787645) Lactococcus lactis subsp. cremoris MG1363 4797379 YP_001033078.1 CDS llmg_1806 NC_009004.1 1787757 1788272 R Region start changed from 1788440 to 1788272 (-168 bases); hypothetical protein complement(1787757..1788272) Lactococcus lactis subsp. cremoris MG1363 4798363 YP_001033079.1 CDS llmg_1807 NC_009004.1 1788380 1789102 R Family membership; nitroreductase complement(1788380..1789102) Lactococcus lactis subsp. cremoris MG1363 4797997 YP_001033080.1 CDS dnaI NC_009004.1 1789095 1789976 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1789095..1789976) Lactococcus lactis subsp. cremoris MG1363 4798453 YP_001033081.1 CDS dnaB NC_009004.1 1789976 1791151 R High confidence in function and specificity; chromosome replication initiation / membrane attachment protein complement(1789976..1791151) Lactococcus lactis subsp. cremoris MG1363 4798390 YP_001033082.1 CDS nrdR NC_009004.1 1791234 1791680 R Protein of unknown function DUF193, Contains ATP- cone domain PF03477; Conserved hypothetical protein; transcriptional regulator NrdR complement(1791234..1791680) Lactococcus lactis subsp. cremoris MG1363 4798374 YP_001033083.1 CDS trmB NC_009004.1 1791868 1792521 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(1791868..1792521) Lactococcus lactis subsp. cremoris MG1363 4797998 YP_001033084.1 CDS llmg_1812 NC_009004.1 1792647 1793420 R Phosphotransferase enzyme family, Similar to choline kinases involved in LPS biosynthesis; kinase complement(1792647..1793420) Lactococcus lactis subsp. cremoris MG1363 4797989 YP_001033085.1 CDS llmg_1813 NC_009004.1 1793489 1793746 R Protein of unknown function DUF1021; hypothetical protein complement(1793489..1793746) Lactococcus lactis subsp. cremoris MG1363 4797394 YP_001033086.1 CDS dnaC NC_009004.1 1793972 1795339 R High confidence in function and specificity; DnaC protein complement(1793972..1795339) Lactococcus lactis subsp. cremoris MG1363 4797404 YP_001033087.1 CDS rplI NC_009004.1 1795345 1795797 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1795345..1795797) Lactococcus lactis subsp. cremoris MG1363 4798375 YP_001033088.1 CDS llmg_1816 NC_009004.1 1795794 1797758 R Phosphoesterase, RecJ-like, DHH family; Conserved hypothetical protein; RecJ-like protein complement(1795794..1797758) Lactococcus lactis subsp. cremoris MG1363 4797927 YP_001033089.1 CDS llmg_1817 NC_009004.1 1797851 1798555 R Family membership; beta-phosphoglucomutase complement(1797851..1798555) Lactococcus lactis subsp. cremoris MG1363 4797392 YP_001033090.1 CDS rmaA NC_009004.1 1798647 1799129 D High confidence in function and specificity; MarR family transcriptional regulator 1798647..1799129 Lactococcus lactis subsp. cremoris MG1363 4798315 YP_001033091.1 CDS llmg_1819 NC_009004.1 1799113 1799976 D patatin like protein; hypothetical protein 1799113..1799976 Lactococcus lactis subsp. cremoris MG1363 4798469 YP_001033092.1 CDS thrA NC_009004.1 1800198 1801550 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 1800198..1801550 Lactococcus lactis subsp. cremoris MG1363 4798458 YP_001033093.1 CDS llmg_1821 NC_009004.1 1801588 1801770 R Similar to C terminal of FloL, flotilin like protein; hypothetical protein complement(1801588..1801770) Lactococcus lactis subsp. cremoris MG1363 4796986 YP_001033094.1 CDS llmg_1822 NC_009004.1 1801934 1803322 R Cof-subfamily: Cof-like hydrolase; hypothetical protein complement(1801934..1803322) Lactococcus lactis subsp. cremoris MG1363 4797987 YP_001033095.1 CDS ansB NC_009004.1 1803517 1804485 D High confidence in function and specificity; L-asparaginase 1803517..1804485 Lactococcus lactis subsp. cremoris MG1363 4798318 YP_001033096.1 CDS llmg_1824 NC_009004.1 1804462 1804557 R hypothetical protein complement(1804462..1804557) Lactococcus lactis subsp. cremoris MG1363 4799136 YP_001033097.1 CDS llmg_1825 NC_009004.1 1804587 1805510 R PF01368.8: Phosphoesterase, RecJ-like, PF02272.6: Phosphoesterase, DHHA1; hypothetical protein complement(1804587..1805510) Lactococcus lactis subsp. cremoris MG1363 4797981 YP_001033098.1 CDS llmg_1826 NC_009004.1 1805605 1806885 R PF00571.15: contains CBS domain; Family membership; hypothetical protein complement(1805605..1806885) Lactococcus lactis subsp. cremoris MG1363 4797985 YP_001033099.1 CDS llmg_1827 NC_009004.1 1806892 1807473 R GCN5-related N-acetyltransferase; Family membership; acetyltransferase complement(1806892..1807473) Lactococcus lactis subsp. cremoris MG1363 4797976 YP_001033100.1 CDS menF NC_009004.1 1807726 1808877 D High confidence in function and specificity; menaquinone-specific isochorismate synthase 1807726..1808877 Lactococcus lactis subsp. cremoris MG1363 4797388 YP_001033101.1 CDS menD NC_009004.1 1808919 1810583 D 2-oxoglutarate decarboxylase 1808919..1810583 Lactococcus lactis subsp. cremoris MG1363 4797539 YP_001033102.1 CDS menX NC_009004.1 1810573 1811388 D contains alpha/beta hydrolase fold; High confidence in function and specificity; menaquinone biosynthesis-like protein 1810573..1811388 Lactococcus lactis subsp. cremoris MG1363 4797549 YP_001033103.1 CDS menB NC_009004.1 1811711 1812553 D catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1811711..1812553 Lactococcus lactis subsp. cremoris MG1363 4797588 YP_001033104.1 CDS menE NC_009004.1 1812710 1814065 D High confidence in function and specificity; O-succinylbenzoic acid--CoA ligase 1812710..1814065 Lactococcus lactis subsp. cremoris MG1363 4797587 YP_001033105.1 CDS menC NC_009004.1 1814062 1815174 D High confidence in function and specificity; o-succinylbenzoate synthase 1814062..1815174 Lactococcus lactis subsp. cremoris MG1363 4797543 YP_001033106.1 CDS llmg_1834 NC_009004.1 1815577 1815987 D Phenylacetic acid degradation-related protein; hypothetical protein 1815577..1815987 Lactococcus lactis subsp. cremoris MG1363 4797564 YP_001033107.1 CDS rliC NC_009004.1 1815995 1816984 R transcriptional regulator, LacI family; High confidence in function and specificity; LacI family transcriptional regulator complement(1815995..1816984) Lactococcus lactis subsp. cremoris MG1363 4797007 YP_001033108.1 CDS xylS NC_009004.1 1817071 1819290 R Glycoside hydrolase, family 31; High confidence in function and specificity; alpha-xylosidase complement(1817071..1819290) Lactococcus lactis subsp. cremoris MG1363 4796679 YP_001033109.1 CDS llmg_1837 NC_009004.1 1819317 1819958 R Protein of unknown function DUF624; Family membership; hypothetical protein complement(1819317..1819958) Lactococcus lactis subsp. cremoris MG1363 4798938 YP_001033110.1 CDS llmg_1838 NC_009004.1 1820036 1821598 R Family membership; sugar ABC transporter substrate-binding protein complement(1820036..1821598) Lactococcus lactis subsp. cremoris MG1363 4797991 YP_001033111.1 CDS llmg_1839 NC_009004.1 1821661 1822275 R Family membership; sugar ABC transporter permease complement(1821661..1822275) Lactococcus lactis subsp. cremoris MG1363 4797990 YP_001033112.1 CDS tnp981 NC_009004.1 1822453 1823292 R Integrase, catalytic region; High confidence in function and specificity; transposase for insertion sequence element IS981O complement(1822453..1823292) Lactococcus lactis subsp. cremoris MG1363 4798457 YP_001033113.1 CDS llmg_1841 NC_009004.1 1823304 1823564 R transposase helper protein for IS981; hypothetical protein complement(1823304..1823564) Lactococcus lactis subsp. cremoris MG1363 4797904 YP_001033114.1 CDS llmg_1842 NC_009004.1 1823644 1823748 D SSF56349: DNA breaking-rejoining enzyme, catalytic core, fragment; hypothetical protein 1823644..1823748 Lactococcus lactis subsp. cremoris MG1363 4797399 YP_001033115.1 CDS llmg_1843 NC_009004.1 1824296 1824763 R cytidine/deoxycytidylate deaminase; hypothetical protein complement(1824296..1824763) Lactococcus lactis subsp. cremoris MG1363 4797996 YP_001033116.1 CDS llmg_1844 NC_009004.1 1824764 1825702 R PF00149.13: Metallophosphoesterase; hypothetical protein complement(1824764..1825702) Lactococcus lactis subsp. cremoris MG1363 4798322 YP_001033117.1 CDS llmg_1845 NC_009004.1 1825690 1826442 R PF00753.14: Beta-lactamase-like; Family membership; metal-dependent hydrolase complement(1825690..1826442) Lactococcus lactis subsp. cremoris MG1363 4797381 YP_001033118.1 CDS cspB NC_009004.1 1826765 1826965 R Cold-shock protein, DNA-binding, 'Cold-shock' DNA- binding domain; Conserved hypothetical protein; cold shock-like protein cspB complement(1826765..1826965) Lactococcus lactis subsp. cremoris MG1363 4797397 YP_001033119.1 CDS cspA NC_009004.1 1827234 1827434 R Nucleic acid-binding OB-fold, 'Cold-shock' DNA- binding domain; Conserved hypothetical protein; cold shock-like protein cspA complement(1827234..1827434) Lactococcus lactis subsp. cremoris MG1363 4798821 YP_001033120.1 CDS llmg_1848 NC_009004.1 1827557 1827757 R hypothetical protein complement(1827557..1827757) Lactococcus lactis subsp. cremoris MG1363 4798820 YP_001033121.1 CDS metE2 NC_009004.1 1828098 1829207 R High confidence in function and specificity; hypothetical protein complement(1828098..1829207) Lactococcus lactis subsp. cremoris MG1363 4798175 YP_001033122.1 CDS qor NC_009004.1 1829375 1830361 D Zinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity; quinone oxidoreductase 1829375..1830361 Lactococcus lactis subsp. cremoris MG1363 4798878 YP_001033123.1 CDS llmg_1851 NC_009004.1 1830390 1831052 R Protein of unknown function DUF1275; Conserved hypothetical protein; hypothetical protein complement(1830390..1831052) Lactococcus lactis subsp. cremoris MG1363 4798415 YP_001033124.1 CDS llmg_1852 NC_009004.1 1831263 1831481 D SSF53056: Carbonic anhydrase, prokaryotic and plant; hypothetical protein 1831263..1831481 Lactococcus lactis subsp. cremoris MG1363 4797978 YP_001033125.1 CDS llmg_1853 NC_009004.1 1831548 1833542 D Protein of unknown function DUF214; Family membership; ABC transporter ATP-binding and permease 1831548..1833542 Lactococcus lactis subsp. cremoris MG1363 4797993 YP_001033126.1 CDS apl NC_009004.1 1833817 1834461 D PF00597.8: DedA family protein; High confidence in function and specificity; alkaline phosphatase 1833817..1834461 Lactococcus lactis subsp. cremoris MG1363 4797386 YP_001033127.1 CDS llmg_1855 NC_009004.1 1834775 1835149 D hypothetical protein 1834775..1835149 Lactococcus lactis subsp. cremoris MG1363 4798947 YP_001033128.1 CDS lmrA NC_009004.1 1835166 1836938 R High confidence in function and specificity; multidrug resistance ABC transporter ATP-binding protein/permease complement(1835166..1836938) Lactococcus lactis subsp. cremoris MG1363 4797383 YP_001033129.1 CDS llmg_1857 NC_009004.1 1837030 1837368 R Conserved hypothetical protein; esterase complement(1837030..1837368) Lactococcus lactis subsp. cremoris MG1363 4797647 YP_001033130.1 CDS llmg_1859 NC_009004.1 1837720 1838208 R Conserved hypothetical protein; flavodoxin complement(1837720..1838208) Lactococcus lactis subsp. cremoris MG1363 4796791 YP_001033131.1 CDS rmaB NC_009004.1 1838235 1839122 R High confidence in function and specificity; MarR family transcriptional regulator complement(1838235..1839122) Lactococcus lactis subsp. cremoris MG1363 4797387 YP_001033132.1 CDS cydD NC_009004.1 1839456 1841177 R involved in the cytochrome D branch of aerobic respiration; High confidence in function and specificity; cytochrome D ABC transporter ATP binding and permease complement(1839456..1841177) Lactococcus lactis subsp. cremoris MG1363 4797221 YP_001033133.1 CDS cydC NC_009004.1 1841177 1842952 R involved in the cytochrome D branch of aerobic respiration; High confidence in function and specificity; cytochrome D ABC transporter ATP binding and permease complement(1841177..1842952) Lactococcus lactis subsp. cremoris MG1363 4798856 YP_001033134.1 CDS cydB NC_009004.1 1843151 1844146 R High confidence in function and specificity; cytochrome d ubiquinol oxidase, subunit II complement(1843151..1844146) Lactococcus lactis subsp. cremoris MG1363 4798853 YP_001033135.1 CDS cydA NC_009004.1 1844146 1845621 R High confidence in function and specificity; cytochrome bd-I ubiquinol oxidase subunit I complement(1844146..1845621) Lactococcus lactis subsp. cremoris MG1363 4798851 YP_001033136.1 CDS dtpT NC_009004.1 1846343 1847836 R POT family protein; High confidence in function and specificity; di-/tripeptide transporter complement(1846343..1847836) Lactococcus lactis subsp. cremoris MG1363 4798848 YP_001033137.1 CDS llmg_1866 NC_009004.1 1848372 1848671 R Conserved hypothetical protein; hypothetical protein complement(1848372..1848671) Lactococcus lactis subsp. cremoris MG1363 4798393 YP_001033138.1 CDS llmg_1867 NC_009004.1 1848710 1848859 R contains Bacteriocin-type signal sequence; hypothetical protein complement(1848710..1848859) Lactococcus lactis subsp. cremoris MG1363 4797385 YP_001033139.1 CDS llmg_1868 NC_009004.1 1848959 1849216 R Family membership; HTH-type transcriptional regulator complement(1848959..1849216) Lactococcus lactis subsp. cremoris MG1363 4796982 YP_001033140.1 CDS apu NC_009004.1 1849292 1851094 R amylopullulanase complement(1849292..1851094) Lactococcus lactis subsp. cremoris MG1363 4797986 YP_001033141.1 CDS llmg_1870 NC_009004.1 1851191 1851337 D hypothetical protein 1851191..1851337 Lactococcus lactis subsp. cremoris MG1363 4797056 YP_001033142.1 CDS glgP NC_009004.1 1851324 1853726 R PF00343.8: Glycosyl transferase, family 35, P_ylase: glycogen/starch/alpha-glucan phosphorylases; High confidence in function and specificity; glycogen phosphorylase complement(1851324..1853726) Lactococcus lactis subsp. cremoris MG1363 4796756 YP_001033143.1 CDS glgA NC_009004.1 1853810 1855282 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(1853810..1855282) Lactococcus lactis subsp. cremoris MG1363 4798517 YP_001033144.1 CDS glgD NC_009004.1 1855336 1856475 R High confidence in function and specificity; glucose-1-phosphate adenylyltransferase complement(1855336..1856475) Lactococcus lactis subsp. cremoris MG1363 4796915 YP_001033145.1 CDS glgC NC_009004.1 1856465 1857607 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(1856465..1857607) Lactococcus lactis subsp. cremoris MG1363 4797208 YP_001033146.1 CDS nusB NC_009004.1 1861256 1862233 R N utilization substance protein B homolog (NusB protein); High confidence in function and specificity; transcription termination protein nusB complement(1861256..1862233) Lactococcus lactis subsp. cremoris MG1363 4798601 YP_001033147.1 CDS llmg_1879 NC_009004.1 1862226 1862627 R Protein of unknown function DUF322; hypothetical protein complement(1862226..1862627) Lactococcus lactis subsp. cremoris MG1363 4798598 YP_001033148.1 CDS efp NC_009004.1 1862774 1863331 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(1862774..1863331) Lactococcus lactis subsp. cremoris MG1363 4796721 YP_001033149.1 CDS pepP NC_009004.1 1863463 1864521 R metallopeptidase M24; High confidence in function and specificity; aminopeptidase complement(1863463..1864521) Lactococcus lactis subsp. cremoris MG1363 4798751 YP_001033150.1 CDS ksgA NC_009004.1 1864629 1865513 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1864629..1865513) Lactococcus lactis subsp. cremoris MG1363 4796867 YP_001033151.1 CDS llmg_1883 NC_009004.1 1865644 1866204 R primaseG_like: primase-related protein, TIGR00334; High confidence in function and specificity; hypothetical protein complement(1865644..1866204) Lactococcus lactis subsp. cremoris MG1363 4797620 YP_001033152.1 CDS flaR NC_009004.1 1866182 1866715 R COG0563: Adenylate kinase and related kinases [Enterococcus faecium]; DNA topology modulation protein FlaR complement(1866182..1866715) Lactococcus lactis subsp. cremoris MG1363 4796812 YP_001033153.1 CDS tatD NC_009004.1 1866749 1867522 R TatD-related deoxyribonuclease, TIGR00010: hydrolase, TatD family; High confidence in function and specificity; deoxyribonuclease complement(1866749..1867522) Lactococcus lactis subsp. cremoris MG1363 4796902 YP_001033154.1 CDS intTn5276 NC_009004.1 1867667 1868806 R DNA breaking-rejoining enzyme, catalytic core; Conserved hypothetical protein; IntTn5276 protein complement(1867667..1868806) Lactococcus lactis subsp. cremoris MG1363 4798760 YP_001033155.1 CDS xisTn5276 NC_009004.1 1868889 1869122 R N-terminal 10aa extension to Tn5276 excisionase in L. lactis reported in database.[alternative start point (ttg)]; Tn5276 excisionase complement(1868889..1869122) Lactococcus lactis subsp. cremoris MG1363 4796628 YP_001033156.1 CDS ardA NC_009004.1 1869149 1869640 R Conserved hypothetical protein; ArdA protein complement(1869149..1869640) Lactococcus lactis subsp. cremoris MG1363 4797932 YP_001033157.1 CDS llmg_1889 NC_009004.1 1869664 1870158 R hypothetical protein complement(1869664..1870158) Lactococcus lactis subsp. cremoris MG1363 4796871 YP_001033158.1 CDS isp2 NC_009004.1 1870253 1870531 R CHAP family similarity although does not contain the invariant Cys,His residues; hypothetical protein complement(1870253..1870531) Lactococcus lactis subsp. cremoris MG1363 4796809 YP_001033159.1 CDS tnp904 NC_009004.1 1872289 1873050 D Conserved hypothetical protein; transposase for insertion sequence IS904H 1872289..1873050 Lactococcus lactis subsp. cremoris MG1363 4798523 YP_001033160.1 CDS llmg_1894 NC_009004.1 1873268 1873849 D Similar to phosphoglycerate/bisphosphoglycerate mutases; High confidence in function and specificity; phosphoglycerate mutase 1873268..1873849 Lactococcus lactis subsp. cremoris MG1363 4798170 YP_001033161.1 CDS phoU NC_009004.1 1873877 1874530 R Conserved hypothetical protein; phosphate transport system regulator phoU complement(1873877..1874530) Lactococcus lactis subsp. cremoris MG1363 4796817 YP_001033162.1 CDS pstA NC_009004.1 1874773 1875534 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1874773..1875534) Lactococcus lactis subsp. cremoris MG1363 4796635 YP_001033163.1 CDS pstB NC_009004.1 1875742 1876551 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1875742..1876551) Lactococcus lactis subsp. cremoris MG1363 4797870 YP_001033164.1 CDS pstC NC_009004.1 1876584 1877477 R Conserved hypothetical protein; phosphate ABC transporter permease complement(1876584..1877477) Lactococcus lactis subsp. cremoris MG1363 4797868 YP_001033165.1 CDS pstD NC_009004.1 1877477 1878400 R Conserved hypothetical protein; phosphate ABC transporter permease complement(1877477..1878400) Lactococcus lactis subsp. cremoris MG1363 4797852 YP_001033166.1 CDS pstE NC_009004.1 1878541 1879392 R Conserved hypothetical protein; phosphate transport substrate binding protein pstE complement(1878541..1879392) Lactococcus lactis subsp. cremoris MG1363 4797846 YP_001033167.1 CDS pstF NC_009004.1 1879732 1880628 R Conserved hypothetical protein; phosphate transport substrate binding protein pstF complement(1879732..1880628) Lactococcus lactis subsp. cremoris MG1363 4797782 YP_001033168.1 CDS smpB NC_009004.1 1880841 1881308 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(1880841..1881308) Lactococcus lactis subsp. cremoris MG1363 4797783 YP_001033169.1 CDS llmg_1903 NC_009004.1 1881373 1881675 R Protein of unknown function DUF24; Conserved hypothetical protein; transcriptional regulator complement(1881373..1881675) Lactococcus lactis subsp. cremoris MG1363 4796685 YP_001033170.1 CDS llmg_1904 NC_009004.1 1881777 1882388 D Similar to NAD(P)H nitroreductases; High confidence in function and specificity; nitroreductase 1881777..1882388 Lactococcus lactis subsp. cremoris MG1363 4797001 YP_001033171.1 CDS llmg_1905 NC_009004.1 1882378 1882941 R GDSL-like Lipase/Acylhydrolase; High confidence in function and specificity; esterase complement(1882378..1882941) Lactococcus lactis subsp. cremoris MG1363 4798534 YP_001033172.1 CDS alaS NC_009004.1 1883038 1885656 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1883038..1885656) Lactococcus lactis subsp. cremoris MG1363 4798416 YP_001033173.1 CDS pmpA NC_009004.1 1885919 1886845 R High confidence in function and specificity; foldase prsA complement(1885919..1886845) Lactococcus lactis subsp. cremoris MG1363 4796714 YP_001033174.1 CDS llmg_1908 NC_009004.1 1886991 1887683 R O-methyltransferase, family 3; High confidence in function and specificity; methyltransferase complement(1886991..1887683) Lactococcus lactis subsp. cremoris MG1363 4797972 YP_001033175.1 CDS pepF NC_009004.1 1887686 1889491 R Peptidase M3B, oligoendopeptidase F; High confidence in function and specificity; PepF protein complement(1887686..1889491) Lactococcus lactis subsp. cremoris MG1363 4797941 YP_001033176.1 CDS llmg_1911 NC_009004.1 1890624 1891709 R Protein of unknown function DUF218; hypothetical protein complement(1890624..1891709) Lactococcus lactis subsp. cremoris MG1363 4798771 YP_001033177.1 CDS llmg_1912 NC_009004.1 1891862 1892710 R COG:4814 Uncharacterized protein with an alpha/beta hydrolase fold, Bacterial protein of unknown function DUF915; hypothetical protein complement(1891862..1892710) Lactococcus lactis subsp. cremoris MG1363 4797942 YP_001033178.1 CDS pbuO NC_009004.1 1892919 1894340 R Xanthine/uracil/vitamin C permease; Conserved hypothetical protein; xanthine/uracil/vitamin C permease complement(1892919..1894340) Lactococcus lactis subsp. cremoris MG1363 4797963 YP_001033179.1 CDS llmg_1914 NC_009004.1 1894647 1895483 D Cof-subfamily: Cof-like hydrolase TIGRFAM00099; Conserved hypothetical protein; hypothetical protein 1894647..1895483 Lactococcus lactis subsp. cremoris MG1363 4798147 YP_001033180.1 CDS llmg_1915 NC_009004.1 1895665 1896435 D Fe-S oxidoreductase 1895665..1896435 Lactococcus lactis subsp. cremoris MG1363 4798446 YP_001033181.1 CDS llmg_1916 NC_009004.1 1896445 1897917 D Similar to electron transport protein ykgF (E. coli), TIGR00273: iron-sulfur cluster binding protein; Conserved hypothetical protein; electron transport protein 1896445..1897917 Lactococcus lactis subsp. cremoris MG1363 4797362 YP_001033182.1 CDS llmg_1917 NC_009004.1 1897920 1898603 D Protein of unknown function DUF162, Uncharacterized ACR, YkgG family COG1556; Conserved hypothetical protein; hypothetical protein 1897920..1898603 Lactococcus lactis subsp. cremoris MG1363 4797370 YP_001033183.1 CDS llmg_1918 NC_009004.1 1898680 1899393 R Protein of unknown function UPF0005; Conserved hypothetical protein; hypothetical protein complement(1898680..1899393) Lactococcus lactis subsp. cremoris MG1363 4797160 YP_001033184.1 CDS llmg_1919 NC_009004.1 1899507 1900421 R Conserved hypothetical protein, similarity to eucaryotic, Diacylglycerol kinase (catalytic domain); hypothetical protein complement(1899507..1900421) Lactococcus lactis subsp. cremoris MG1363 4798286 YP_001033185.1 CDS llmg_1920 NC_009004.1 1900601 1901113 R Metal-dependent phosphohydrolase, HD region; hypothetical protein complement(1900601..1901113) Lactococcus lactis subsp. cremoris MG1363 4797855 YP_001033186.1 CDS rpsT NC_009004.1 1901443 1901676 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1901443..1901676 Lactococcus lactis subsp. cremoris MG1363 4797837 YP_001033187.1 CDS recD NC_009004.1 1901770 1904271 R RecD/TraA family; High confidence in function and specificity; exodeoxyribonuclease V subunit alpha complement(1901770..1904271) Lactococcus lactis subsp. cremoris MG1363 4797368 YP_001033188.1 CDS gpmC NC_009004.1 1904268 1904861 R 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; High confidence in function and specificity; phosphoglycerate mutase complement(1904268..1904861) Lactococcus lactis subsp. cremoris MG1363 4796607 YP_001033189.1 CDS pheA NC_009004.1 1904864 1905703 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1904864..1905703) Lactococcus lactis subsp. cremoris MG1363 4798602 YP_001033190.1 CDS aroK NC_009004.1 1905705 1906193 R AroK protein complement(1905705..1906193) Lactococcus lactis subsp. cremoris MG1363 4798412 YP_001033191.1 CDS aroA NC_009004.1 1906217 1907509 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1906217..1907509) Lactococcus lactis subsp. cremoris MG1363 4798266 YP_001033192.1 CDS tyrA NC_009004.1 1907629 1908693 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1907629..1908693) Lactococcus lactis subsp. cremoris MG1363 4799070 YP_001033193.1 CDS kinG NC_009004.1 1908697 1909572 R Histidine kinase; High confidence in function and specificity; sensor histidine kinase complement(1908697..1909572) Lactococcus lactis subsp. cremoris MG1363 4798278 YP_001033194.1 CDS llrG NC_009004.1 1909559 1910230 R Response regulator; Conserved hypothetical protein; response regulator complement(1909559..1910230) Lactococcus lactis subsp. cremoris MG1363 4797728 YP_001033195.1 CDS llmg_1930 NC_009004.1 1910233 1911297 R VanZ like family; hypothetical protein complement(1910233..1911297) Lactococcus lactis subsp. cremoris MG1363 4796701 YP_001033196.1 CDS llmg_1932 NC_009004.1 1913487 1914266 R Sulfate/thiosulfate import ATP-binding protein cysA. ABC transporter related; High confidence in function and specificity; Sulfate/thiosulfate import ATP-binding protein cysA complement(1913487..1914266) Lactococcus lactis subsp. cremoris MG1363 4798255 YP_001033197.1 CDS llmg_1933 NC_009004.1 1914460 1914816 R Conserved hypothetical protein; hypothetical protein complement(1914460..1914816) Lactococcus lactis subsp. cremoris MG1363 4797441 YP_001033198.1 CDS aroC NC_009004.1 1914939 1916105 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1914939..1916105) Lactococcus lactis subsp. cremoris MG1363 4798316 YP_001033199.1 CDS llmg_1936 NC_009004.1 1916738 1917337 R Protein of unknown function DUF1054; hypothetical protein complement(1916738..1917337) Lactococcus lactis subsp. cremoris MG1363 4798766 YP_001033200.1 CDS llmg_1937 NC_009004.1 1917709 1918632 R Protein of unknown function DUF606; hypothetical protein complement(1917709..1918632) Lactococcus lactis subsp. cremoris MG1363 4797815 YP_001033201.1 CDS aroB NC_009004.1 1918746 1919816 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1918746..1919816) Lactococcus lactis subsp. cremoris MG1363 4797811 YP_001033202.1 CDS aroE NC_009004.1 1919813 1920673 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1919813..1920673) Lactococcus lactis subsp. cremoris MG1363 4798936 YP_001033203.1 CDS llmg_1941 NC_009004.1 1920851 1921510 R DedA family; hypothetical protein complement(1920851..1921510) Lactococcus lactis subsp. cremoris MG1363 4798102 YP_001033204.1 CDS glnP NC_009004.1 1921895 1924039 D glutamine ABC transporter permease and substrate binding protein; High confidence in function and specificity; glutamine ABC transporter permease and substrate binding protein 1921895..1924039 Lactococcus lactis subsp. cremoris MG1363 4797831 YP_001033205.1 CDS glnQ NC_009004.1 1924062 1924805 D High confidence in function and specificity; glutamine ABC transporter ATP-binding protein 1924062..1924805 Lactococcus lactis subsp. cremoris MG1363 4797844 YP_001033206.1 CDS llmg_1944 NC_009004.1 1924864 1926804 R hypothetical protein complement(1924864..1926804) Lactococcus lactis subsp. cremoris MG1363 4798031 YP_001033207.1 CDS atpC NC_009004.1 1926908 1927333 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(1926908..1927333) Lactococcus lactis subsp. cremoris MG1363 4798465 YP_001033208.1 CDS atpD NC_009004.1 1927518 1928978 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(1927518..1928978) Lactococcus lactis subsp. cremoris MG1363 4797781 YP_001033209.1 CDS atpG NC_009004.1 1929099 1929968 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(1929099..1929968) Lactococcus lactis subsp. cremoris MG1363 4797793 YP_001033210.1 CDS atpA NC_009004.1 1929984 1931486 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(1929984..1931486) Lactococcus lactis subsp. cremoris MG1363 4798114 YP_001033211.1 CDS atpH NC_009004.1 1931675 1932202 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(1931675..1932202) Lactococcus lactis subsp. cremoris MG1363 4798488 YP_001033212.1 CDS atpF NC_009004.1 1932204 1932710 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(1932204..1932710) Lactococcus lactis subsp. cremoris MG1363 4798625 YP_001033213.1 CDS atpB NC_009004.1 1932725 1933438 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(1932725..1933438) Lactococcus lactis subsp. cremoris MG1363 4797802 YP_001033214.1 CDS atpE NC_009004.1 1933485 1933700 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(1933485..1933700) Lactococcus lactis subsp. cremoris MG1363 4797764 YP_001033215.1 CDS estA NC_009004.1 1933883 1934659 R esterase; High confidence in function and specificity; tributyrin esterase complement(1933883..1934659) Lactococcus lactis subsp. cremoris MG1363 4797796 YP_001033216.1 CDS comEA NC_009004.1 1937133 1937747 R Competence protein ComEA helix-hairpin-helix region; High confidence in function and specificity; competence protein complement(1937133..1937747) Lactococcus lactis subsp. cremoris MG1363 4798781 YP_001033217.1 CDS llmg_1956 NC_009004.1 1937847 1939208 R ABC transporter permease; Conserved hypothetical protein; hypothetical protein complement(1937847..1939208) Lactococcus lactis subsp. cremoris MG1363 4798777 YP_001033218.1 CDS llmg_1957 NC_009004.1 1939205 1940137 R ABC transporter ATP binding protein; High confidence in function and specificity; ABC transporter ATP-binding protein complement(1939205..1940137) Lactococcus lactis subsp. cremoris MG1363 4797788 YP_001033219.1 CDS llmg_1958 NC_009004.1 1940243 1940428 R hypothetical protein complement(1940243..1940428) Lactococcus lactis subsp. cremoris MG1363 4798627 YP_001033220.1 CDS bar NC_009004.1 1940757 1941317 R Phosphinothricin N-acetyltransferase (GNAT) family; High confidence in function and specificity; phosphinothricin N-acetyltransferase complement(1940757..1941317) Lactococcus lactis subsp. cremoris MG1363 4797833 YP_001033221.1 CDS llmg_1960 NC_009004.1 1941491 1942669 R cation transporter; Conserved hypothetical protein; hypothetical protein complement(1941491..1942669) Lactococcus lactis subsp. cremoris MG1363 4798640 YP_001033222.1 CDS tenA NC_009004.1 1943058 1943714 R TENA/THI-4 protein; High confidence in function and specificity; transcriptional activator TenA complement(1943058..1943714) Lactococcus lactis subsp. cremoris MG1363 4798435 YP_001033223.1 CDS llmg_1962 NC_009004.1 1943932 1944261 R CHY zinc finger; Conserved hypothetical protein; hypothetical protein complement(1943932..1944261) Lactococcus lactis subsp. cremoris MG1363 4797536 YP_001033224.1 CDS birA1 NC_009004.1 1944255 1945226 R Biotin-- [acetyl-CoA-carboxylase] synthetase; High confidence in function and specificity; biotin--[acetyl-CoA-carboxylase] ligase and biotin operon repressor complement(1944255..1945226) Lactococcus lactis subsp. cremoris MG1363 4797525 YP_001033225.1 CDS bioY NC_009004.1 1945232 1945801 R BioY protein; Conserved hypothetical protein; hypothetical protein complement(1945232..1945801) Lactococcus lactis subsp. cremoris MG1363 4798221 YP_001033226.1 CDS llmg_1965 NC_009004.1 1945938 1947182 D Acetyl-coenzyme A synthetase; High confidence in function and specificity; AMP-binding protein 1945938..1947182 Lactococcus lactis subsp. cremoris MG1363 4798301 YP_001033227.1 CDS llmg_1966 NC_009004.1 1948940 1949203 R hypothetical protein complement(1948940..1949203) Lactococcus lactis subsp. cremoris MG1363 4798019 YP_001033228.1 CDS llmg_1967 NC_009004.1 1949203 1949673 R hypothetical protein complement(1949203..1949673) Lactococcus lactis subsp. cremoris MG1363 4797806 YP_001033229.1 CDS llmg_1968 NC_009004.1 1949781 1950071 R Conserved hypothetical protein; hypothetical protein complement(1949781..1950071) Lactococcus lactis subsp. cremoris MG1363 4798700 YP_001033230.1 CDS sufB NC_009004.1 1950420 1951832 R FeS assembly protein SufB; hypothetical protein complement(1950420..1951832) Lactococcus lactis subsp. cremoris MG1363 4798702 YP_001033231.1 CDS nifU NC_009004.1 1951928 1952386 R May be involved in the formation or repair of [Fe- S] clusters present in iron-sulfur proteins; hypothetical protein complement(1951928..1952386) Lactococcus lactis subsp. cremoris MG1363 4798596 YP_001033232.1 CDS llmg_1971 NC_009004.1 1952520 1953002 R hypothetical protein complement(1952520..1953002) Lactococcus lactis subsp. cremoris MG1363 4797952 YP_001033233.1 CDS llmg_1972 NC_009004.1 1953004 1954221 R cysteine desulfurases, SufS subfamily; High confidence in function and specificity; hypothetical protein complement(1953004..1954221) Lactococcus lactis subsp. cremoris MG1363 4798707 YP_001033234.1 CDS llmg_1973 NC_009004.1 1954221 1955477 R FeS assembly protein SufD; hypothetical protein complement(1954221..1955477) Lactococcus lactis subsp. cremoris MG1363 4798576 YP_001033235.1 CDS llmg_1974 NC_009004.1 1955617 1956387 R ATP-dependent transporter; Conserved hypothetical protein; ATP-dependent transporter complement(1955617..1956387) Lactococcus lactis subsp. cremoris MG1363 4798719 YP_001033236.1 CDS llmg_1975 NC_009004.1 1956608 1957177 D hypothetical protein 1956608..1957177 Lactococcus lactis subsp. cremoris MG1363 4798698 YP_001033237.1 CDS llmg_1976 NC_009004.1 1958065 1959390 R Phospho-N-acetylmuramoyl-pentapeptide-transferase. Glycosyl transferase; High confidence in function and specificity; polysaccharide biosynthesis protein complement(1958065..1959390) Lactococcus lactis subsp. cremoris MG1363 4798528 YP_001033238.1 CDS llmg_1977 NC_009004.1 1959393 1960094 R Similar to B. subtilis MecA,(Negative regulator of genetic competence in B. subtilis); High confidence in function and specificity; MecA-like protein complement(1959393..1960094) Lactococcus lactis subsp. cremoris MG1363 4798567 YP_001033239.1 CDS gltQ NC_009004.1 1960224 1960958 R Glutamate ABC transporter ATP binding protein; Conserved hypothetical protein; glutamate ABC transporter ATP-binding protein complement(1960224..1960958) Lactococcus lactis subsp. cremoris MG1363 4798575 YP_001033240.1 CDS gltP NC_009004.1 1960958 1961644 R amino acid ABC transporter permease; High confidence in function and specificity; glutamate ABC transporter permease complement(1960958..1961644) Lactococcus lactis subsp. cremoris MG1363 4798813 YP_001033241.1 CDS llmg_1980 NC_009004.1 1961791 1962699 R Diacylglycerol kinase catalytic domain; hypothetical protein complement(1961791..1962699) Lactococcus lactis subsp. cremoris MG1363 4796841 YP_001033242.1 CDS rpoC NC_009004.1 1962823 1966446 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1962823..1966446) Lactococcus lactis subsp. cremoris MG1363 4798573 YP_001033243.1 CDS rpoB NC_009004.1 1966555 1970145 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1966555..1970145) Lactococcus lactis subsp. cremoris MG1363 4798827 YP_001033244.1 CDS codZ NC_009004.1 1970414 1971013 R transcriptional repressor, CodY family; High confidence in function and specificity; CodY family transcriptional regulator complement(1970414..1971013) Lactococcus lactis subsp. cremoris MG1363 4798826 YP_001033245.1 CDS llmg_1984 NC_009004.1 1971249 1971923 D Family membership; transcriptional regulator 1971249..1971923 Lactococcus lactis subsp. cremoris MG1363 4798768 YP_001033246.1 CDS pepO2 NC_009004.1 1972038 1973921 D Peptidase M13; High confidence in function and specificity; neutral endopeptidase O2 1972038..1973921 Lactococcus lactis subsp. cremoris MG1363 4798570 YP_001033247.1 CDS llmg_1986 NC_009004.1 1973970 1974275 R methylated-DNA--protein-cysteine methyltransferase; High confidence in function and specificity; hypothetical protein complement(1973970..1974275) Lactococcus lactis subsp. cremoris MG1363 4798131 YP_001033248.1 CDS llmg_1988 NC_009004.1 1974345 1976018 R Polysaccharide biosynthesis protein; hypothetical protein complement(1974345..1976018) Lactococcus lactis subsp. cremoris MG1363 4798578 YP_001033249.1 CDS murE NC_009004.1 1976229 1977680 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1976229..1977680 Lactococcus lactis subsp. cremoris MG1363 4798713 YP_001033250.1 CDS llmg_1990 NC_009004.1 1977762 1978022 R SSF47413: Lambda repressor-like, DNA-binding; hypothetical protein complement(1977762..1978022) Lactococcus lactis subsp. cremoris MG1363 4796913 YP_001033251.1 CDS adhA NC_009004.1 1978043 1979065 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1978043..1979065) Lactococcus lactis subsp. cremoris MG1363 4798721 YP_001033252.1 CDS recQ NC_009004.1 1979285 1981063 D ATP-requiring DNA helicase RecQ; High confidence in function and specificity; ATP-dependent DNA helicase RecQ 1979285..1981063 Lactococcus lactis subsp. cremoris MG1363 4797653 YP_001033253.1 CDS llmg_1993 NC_009004.1 1981100 1982623 R Amino acid permease-associated region; High confidence in function and specificity; transporter complement(1981100..1982623) Lactococcus lactis subsp. cremoris MG1363 4797055 YP_001033254.1 CDS pepT NC_009004.1 1982905 1984146 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(1982905..1984146) Lactococcus lactis subsp. cremoris MG1363 4798720 YP_001033255.1 CDS llmg_1995 NC_009004.1 1984175 1984972 R hypothetical protein complement(1984175..1984972) Lactococcus lactis subsp. cremoris MG1363 4798132 YP_001033256.1 CDS ppa NC_009004.1 1984972 1985916 R catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase complement(1984972..1985916) Lactococcus lactis subsp. cremoris MG1363 4798571 YP_001033257.1 CDS pflA NC_009004.1 1986117 1986908 R Pyruvate formate-lyase 1 activating enzyme; High confidence in function and specificity; pyruvate-formate lyase activating enzyme complement(1986117..1986908) Lactococcus lactis subsp. cremoris MG1363 4797023 YP_001033258.1 CDS llmg_1999 NC_009004.1 1987127 1988464 R Protein of unknown function DUF21; hypothetical protein complement(1987127..1988464) Lactococcus lactis subsp. cremoris MG1363 4797309 YP_001033259.1 CDS llmg_2000 NC_009004.1 1988584 1989699 R Protein of unknown function DUF20; Conserved hypothetical protein; permease complement(1988584..1989699) Lactococcus lactis subsp. cremoris MG1363 4798715 YP_001033260.1 CDS llmg_2002 NC_009004.1 1990003 1990467 R Protein of unknown function; hypothetical protein complement(1990003..1990467) Lactococcus lactis subsp. cremoris MG1363 4798579 YP_001033261.1 CDS llmg_2003 NC_009004.1 1990464 1991033 R High confidence in function and specificity; UDP-glucose 4-epimerase complement(1990464..1991033) Lactococcus lactis subsp. cremoris MG1363 4798709 YP_001033262.1 CDS llmg_2004 NC_009004.1 1991280 1991732 D probable acetyltransferase (GNAT) family; hypothetical protein 1991280..1991732 Lactococcus lactis subsp. cremoris MG1363 4798723 YP_001033263.1 CDS llmg_2005 NC_009004.1 1991789 1992226 R cell wall hydrolase complement(1991789..1992226) Lactococcus lactis subsp. cremoris MG1363 4798718 YP_001033264.1 CDS llmg_2006 NC_009004.1 1992275 1992862 D zimilar to prophage pi3 protein 58; hypothetical protein 1992275..1992862 Lactococcus lactis subsp. cremoris MG1363 4798703 YP_001033265.1 CDS llmg_2007 NC_009004.1 1992989 1993570 R Uracil-DNA glycosylase superfamily; Conserved hypothetical protein; hypothetical protein complement(1992989..1993570) Lactococcus lactis subsp. cremoris MG1363 4798722 YP_001033266.1 CDS uvrA NC_009004.1 1993652 1996483 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(1993652..1996483) Lactococcus lactis subsp. cremoris MG1363 4796829 YP_001033267.1 CDS llmg_2009 NC_009004.1 1996628 1997266 R hypothetical protein complement(1996628..1997266) Lactococcus lactis subsp. cremoris MG1363 4797344 YP_001033268.1 CDS llmg_2010 NC_009004.1 1997373 1997669 D hypothetical protein 1997373..1997669 Lactococcus lactis subsp. cremoris MG1363 4797493 YP_001033269.1 CDS llmg_2011 NC_009004.1 1997679 1999052 R Family membership; amino acid permease complement(1997679..1999052) Lactococcus lactis subsp. cremoris MG1363 4797475 YP_001033270.1 CDS llmg_2012 NC_009004.1 1999452 2000369 R Oxidoreductase, Oxidoreductase, NAD- binding Rossmann fold; hypothetical protein complement(1999452..2000369) Lactococcus lactis subsp. cremoris MG1363 4798287 YP_001033271.1 CDS thiN NC_009004.1 2000399 2001034 R PF04263.5: Thiamin pyrophosphokinase, catalytic region, PF04265: Thiamin pyrophosphokinase, vitamin B1 binding domain; High confidence in function and specificity; thiamin pyrophosphokinase complement(2000399..2001034) Lactococcus lactis subsp. cremoris MG1363 4799053 YP_001033272.1 CDS llmg_2014 NC_009004.1 2001031 2001378 R pyrophosphohydrolase, MazG-related, GP37 type; hypothetical protein complement(2001031..2001378) Lactococcus lactis subsp. cremoris MG1363 4796890 YP_001033273.1 CDS llmg_2015 NC_009004.1 2001410 2001859 R hypothetical protein complement(2001410..2001859) Lactococcus lactis subsp. cremoris MG1363 4799033 YP_001033274.1 CDS llmg_2016 NC_009004.1 2002053 2002571 D hypothetical protein 2002053..2002571 Lactococcus lactis subsp. cremoris MG1363 4798079 YP_001033275.1 CDS asnC NC_009004.1 2002619 2003962 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(2002619..2003962) Lactococcus lactis subsp. cremoris MG1363 4796865 YP_001033276.1 CDS llmg_2018 NC_009004.1 2004010 2004321 R hypothetical protein complement(2004010..2004321) Lactococcus lactis subsp. cremoris MG1363 4797206 YP_001033277.1 CDS aspB NC_009004.1 2004314 2005495 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(2004314..2005495) Lactococcus lactis subsp. cremoris MG1363 4796808 YP_001033278.1 CDS llmg_2020 NC_009004.1 2005492 2005935 R hypothetical protein complement(2005492..2005935) Lactococcus lactis subsp. cremoris MG1363 4797205 YP_001033279.1 CDS dinG NC_009004.1 2006071 2008446 R DnaQ exonuclease/DinG family helicase; High confidence in function and specificity; ATP-dependent helicase dinG-like protein complement(2006071..2008446) Lactococcus lactis subsp. cremoris MG1363 4798775 YP_001033280.1 CDS llmg_2022 NC_009004.1 2008550 2008672 D hypothetical protein 2008550..2008672 Lactococcus lactis subsp. cremoris MG1363 4798911 YP_001033281.1 CDS llmg_2023 NC_009004.1 2008694 2009131 D UspA Universal stress protein family; High confidence in function and specificity; universal stress protein A 2008694..2009131 Lactococcus lactis subsp. cremoris MG1363 4798067 YP_001033282.1 CDS oppA2 NC_009004.1 2009303 2011105 R Bacterial extracellular solute-binding protein; High confidence in function and specificity; oligopeptide-binding protein oppA2 precursor complement(2009303..2011105) Lactococcus lactis subsp. cremoris MG1363 4798123 YP_001033283.1 CDS oppC2 NC_009004.1 2011218 2012102 R Binding-protein-dependent transport systems inner membrane component; High confidence in function and specificity; oligopeptide transport system permease oppC2 complement(2011218..2012102) Lactococcus lactis subsp. cremoris MG1363 4799092 YP_001033284.1 CDS oppB2 NC_009004.1 2012112 2013071 R Binding-protein-dependent transport systems inner membrane component; High confidence in function and specificity; peptide transport system permease oppB2 complement(2012112..2013071) Lactococcus lactis subsp. cremoris MG1363 4799088 YP_001033285.1 CDS rplT NC_009004.1 2015238 2015597 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(2015238..2015597) Lactococcus lactis subsp. cremoris MG1363 4799086 YP_001033286.1 CDS rpmI NC_009004.1 2015861 2016061 R Ribosomal protein L35; Conserved hypothetical protein; 50S ribosomal protein L35 complement(2015861..2016061) Lactococcus lactis subsp. cremoris MG1363 4797849 YP_001033287.1 CDS infC NC_009004.1 2016189 2016839 R IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 complement(2016189..2016839) Lactococcus lactis subsp. cremoris MG1363 4798807 YP_001033288.1 CDS llmg_2032 NC_009004.1 2017144 2017272 D hypothetical protein 2017144..2017272 Lactococcus lactis subsp. cremoris MG1363 4796686 YP_001033289.1 CDS llmg_2033 NC_009004.1 2017303 2017851 D hypothetical protein 2017303..2017851 Lactococcus lactis subsp. cremoris MG1363 4798093 YP_001033290.1 CDS llmg_2034 NC_009004.1 2017879 2018565 R Haloacid dehalogenase-like hydrolase, HAD superfamily; HAD superfamily hydrolase complement(2017879..2018565) Lactococcus lactis subsp. cremoris MG1363 4798099 YP_001033291.1 CDS gidA NC_009004.1 2018737 2020614 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(2018737..2020614) Lactococcus lactis subsp. cremoris MG1363 4798083 YP_001033292.1 CDS llmg_2036 NC_009004.1 2020999 2021562 R hypothetical protein complement(2020999..2021562) Lactococcus lactis subsp. cremoris MG1363 4799132 YP_001033293.1 CDS llmg_2037 NC_009004.1 2021695 2022063 R Protein of unknown function DUF1033; hypothetical protein complement(2021695..2022063) Lactococcus lactis subsp. cremoris MG1363 4796769 YP_001033294.1 CDS llmg_2039 NC_009004.1 2022177 2022596 R Uncharacterised conserved protein; Conserved hypothetical protein; ribonuclease III complement(2022177..2022596) Lactococcus lactis subsp. cremoris MG1363 4798096 YP_001033295.1 CDS cysS NC_009004.1 2022571 2023917 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(2022571..2023917) Lactococcus lactis subsp. cremoris MG1363 4798035 YP_001033296.1 CDS llmg_2041 NC_009004.1 2023930 2024523 R Protein of unknown function DUF1211; hypothetical protein complement(2023930..2024523) Lactococcus lactis subsp. cremoris MG1363 4798867 YP_001033297.1 CDS cysE NC_009004.1 2024537 2025136 R serine O-acetyltransferase; High confidence in function and specificity; serine acetyltransferase complement(2024537..2025136) Lactococcus lactis subsp. cremoris MG1363 4797797 YP_001033298.1 CDS llmg_2043 NC_009004.1 2025242 2026012 R hypothetical protein complement(2025242..2026012) Lactococcus lactis subsp. cremoris MG1363 4798864 YP_001033299.1 CDS pnpA NC_009004.1 2026280 2028580 R Polyribonucleotide nucleotidyltransferase; High confidence in function and specificity; polynucleotide phosphorylase complement(2026280..2028580) Lactococcus lactis subsp. cremoris MG1363 4799121 YP_001033300.1 CDS prsA NC_009004.1 2028861 2030006 R phosphoribosylpyrophosphate synthetase; hypothetical protein complement(2028861..2030006) Lactococcus lactis subsp. cremoris MG1363 4799065 YP_001033301.1 CDS prsB NC_009004.1 2030371 2031336 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 2030371..2031336 Lactococcus lactis subsp. cremoris MG1363 4796992 YP_001033302.1 CDS llmg_2047 NC_009004.1 2031441 2031872 R UspA Universal stress protein family; Conserved hypothetical protein; universal stress protein E complement(2031441..2031872) Lactococcus lactis subsp. cremoris MG1363 4798546 YP_001033303.1 CDS nifS NC_009004.1 2032415 2033296 D Cysteine desulfurase/Cysteine sulfinate desulfinase; High confidence in function and specificity; iron-sulfur cofactor synthesis protein 2032415..2033296 Lactococcus lactis subsp. cremoris MG1363 4796820 YP_001033304.1 CDS llmg_2049 NC_009004.1 2033322 2033666 D hypothetical protein 2033322..2033666 Lactococcus lactis subsp. cremoris MG1363 4797248 YP_001033305.1 CDS tufA NC_009004.1 2033755 2034942 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(2033755..2034942) Lactococcus lactis subsp. cremoris MG1363 4798092 YP_001033306.1 CDS llmg_2051 NC_009004.1 2035186 2035368 D hypothetical protein 2035186..2035368 Lactococcus lactis subsp. cremoris MG1363 4798244 YP_001033307.1 CDS llmg_2052 NC_009004.1 2035427 2035543 D hypothetical protein 2035427..2035543 Lactococcus lactis subsp. cremoris MG1363 4798084 YP_001033308.1 CDS ileS NC_009004.1 2035603 2038401 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(2035603..2038401) Lactococcus lactis subsp. cremoris MG1363 4797961 YP_001033309.1 CDS llmg_2054 NC_009004.1 2038605 2038745 D hypothetical protein 2038605..2038745 Lactococcus lactis subsp. cremoris MG1363 4797630 YP_001033310.1 CDS llmg_2055 NC_009004.1 2038848 2039783 R cell division initiation protein, DivIVA; hypothetical protein complement(2038848..2039783) Lactococcus lactis subsp. cremoris MG1363 4798451 YP_001033311.1 CDS llmg_2056 NC_009004.1 2039840 2040559 R hypothetical protein complement(2039840..2040559) Lactococcus lactis subsp. cremoris MG1363 4797367 YP_001033312.1 CDS llmg_2057 NC_009004.1 2040628 2040903 R Protein of unknown function,YGGT protein family, predicted integral membrane protein; hypothetical protein complement(2040628..2040903) Lactococcus lactis subsp. cremoris MG1363 4797372 YP_001033313.1 CDS llmg_2058 NC_009004.1 2040903 2041493 R Protein of unknown function DUF552; Conserved hypothetical protein; hypothetical protein complement(2040903..2041493) Lactococcus lactis subsp. cremoris MG1363 4796848 YP_001033314.1 CDS llmg_2059 NC_009004.1 2041527 2042204 R Protein of unknown function UPF0001, conserved hypothetical protein; hypothetical protein complement(2041527..2042204) Lactococcus lactis subsp. cremoris MG1363 4798663 YP_001033315.1 CDS ftsZ NC_009004.1 2042201 2043460 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(2042201..2043460) Lactococcus lactis subsp. cremoris MG1363 4798073 YP_001033316.1 CDS ftsA NC_009004.1 2043490 2044860 R Cell division protein FtsA; High confidence in function and specificity; cell division protein ftsA complement(2043490..2044860) Lactococcus lactis subsp. cremoris MG1363 4797264 YP_001033317.1 CDS llmg_2062 NC_009004.1 2045022 2045891 R Uncharacterized protein, DegV family COG1307; Conserved hypothetical protein; hypothetical protein complement(2045022..2045891) Lactococcus lactis subsp. cremoris MG1363 4798300 YP_001033318.1 CDS trmH NC_009004.1 2046008 2046736 R 23S ribosomal RNA methyltransferase, TrmH family; High confidence in function and specificity; tRNA/rRNA methyltransferase complement(2046008..2046736) Lactococcus lactis subsp. cremoris MG1363 4798072 YP_001033319.1 CDS llmg_2064 NC_009004.1 2046900 2048000 R Oxidoreductase, Glycine/D-amino acid oxidase; High confidence in function and specificity; oxidoreductase complement(2046900..2048000) Lactococcus lactis subsp. cremoris MG1363 4799046 YP_001033320.1 CDS llmg_2065 NC_009004.1 2048138 2048983 R Aldo/keto reductase; Family membership; aldo/keto reductase complement(2048138..2048983) Lactococcus lactis subsp. cremoris MG1363 4798065 YP_001033321.1 CDS llmg_2066 NC_009004.1 2048995 2050320 R Multidrug resistance protein B, permease of the Major facilitator superfamily, EmrB family; High confidence in function and specificity; multidrug resistance protein B complement(2048995..2050320) Lactococcus lactis subsp. cremoris MG1363 4798452 YP_001033322.1 CDS rlrB NC_009004.1 2050435 2051313 R HTH type transcriptional regulator, LysR family; Conserved hypothetical protein; LysR family transcriptional regulator complement(2050435..2051313) Lactococcus lactis subsp. cremoris MG1363 4797374 YP_001033323.1 CDS rmeA NC_009004.1 2051329 2051733 R HTH-type transcriptional regulator, MerR family; High confidence in function and specificity; MerR family transcriptional regulator complement(2051329..2051733) Lactococcus lactis subsp. cremoris MG1363 4797132 YP_001033324.1 CDS pepC NC_009004.1 2051813 2053177 R PepC protein complement(2051813..2053177) Lactococcus lactis subsp. cremoris MG1363 4798018 YP_001033325.1 CDS llmg_2070 NC_009004.1 2053252 2053926 R Hypothetical protein in pepC 5'region (ORF 2, Metal- dependent phosphohydrolase, HD domain; High confidence in function and specificity; hypothetical protein complement(2053252..2053926) Lactococcus lactis subsp. cremoris MG1363 4798037 YP_001033326.1 CDS llmg_2071 NC_009004.1 2053944 2054447 R hypothetical protein complement(2053944..2054447) Lactococcus lactis subsp. cremoris MG1363 4797688 YP_001033327.1 CDS llmg_2072 NC_009004.1 2054401 2054514 R hypothetical protein complement(2054401..2054514) Lactococcus lactis subsp. cremoris MG1363 4798211 YP_001033328.1 CDS pfs NC_009004.1 2054584 2055264 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(2054584..2055264) Lactococcus lactis subsp. cremoris MG1363 4797803 YP_001033329.1 CDS llmg_2074 NC_009004.1 2055292 2055570 R hypothetical protein complement(2055292..2055570) Lactococcus lactis subsp. cremoris MG1363 4796815 YP_001033330.1 CDS llmg_2075 NC_009004.1 2055563 2056147 R ADP-ribose pyrophosphatase, MutT/nudix family; High confidence in function and specificity; ADP-ribose pyrophosphatase complement(2055563..2056147) Lactococcus lactis subsp. cremoris MG1363 4797281 YP_001033331.1 CDS glmU NC_009004.1 2056248 2057624 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(2056248..2057624) Lactococcus lactis subsp. cremoris MG1363 4797872 YP_001033332.1 CDS proC NC_009004.1 2057845 2058636 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 2057845..2058636 Lactococcus lactis subsp. cremoris MG1363 4797351 YP_001033333.1 CDS rpsO NC_009004.1 2058720 2059043 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(2058720..2059043) Lactococcus lactis subsp. cremoris MG1363 4796767 YP_001033334.1 CDS pknB NC_009004.1 2059160 2061037 R serine/threonine protein kinase complement(2059160..2061037) Lactococcus lactis subsp. cremoris MG1363 4797201 YP_001033335.1 CDS pppL NC_009004.1 2061037 2061813 R Protein phosphatase 2C-like; High confidence in function and specificity; phosphoprotein phosphatase complement(2061037..2061813) Lactococcus lactis subsp. cremoris MG1363 4796750 YP_001033336.1 CDS sunL NC_009004.1 2061936 2063210 R Ribosomal RNA small subunit methyltransferase B, NusB/NOL1/NOP2/sun family; High confidence in function and specificity; ribosomal RNA small subunit methyltransferase B complement(2061936..2063210) Lactococcus lactis subsp. cremoris MG1363 4796892 YP_001033337.1 CDS ps461 NC_009004.1 2064418 2065275 R phage lysin, cell wall hydrolase; High confidence in function and specificity; bacteriophage lysin complement(2064418..2065275) Lactococcus lactis subsp. cremoris MG1363 4798734 YP_001033338.1 CDS ps460 NC_009004.1 2065277 2065738 R Phage holin, LL-H; High confidence in function and specificity; bacteriophage holin complement(2065277..2065738) Lactococcus lactis subsp. cremoris MG1363 4798043 YP_001033339.1 CDS ps459 NC_009004.1 2065754 2066101 R hypothetical protein complement(2065754..2066101) Lactococcus lactis subsp. cremoris MG1363 4798078 YP_001033340.1 CDS ps458 NC_009004.1 2066114 2066350 R hypothetical protein complement(2066114..2066350) Lactococcus lactis subsp. cremoris MG1363 4798345 YP_001033341.1 CDS ps457 NC_009004.1 2066366 2071219 R Phage minor structural protein, N-terminal, probable phage host specificity protein; High confidence in function and specificity; serine/threonine-rich protein precursor complement(2066366..2071219) Lactococcus lactis subsp. cremoris MG1363 4797331 YP_001033342.1 CDS ps455 NC_009004.1 2071216 2072298 R phage tail component protein; High confidence in function and specificity; phage tail component complement(2071216..2072298) Lactococcus lactis subsp. cremoris MG1363 4796578 YP_001033343.1 CDS ps454 NC_009004.1 2072222 2072869 R tail protein; hypothetical protein complement(2072222..2072869) Lactococcus lactis subsp. cremoris MG1363 4796627 YP_001033344.1 CDS ps453 NC_009004.1 2072866 2078013 R phage tail component; High confidence in function and specificity; phage tail component complement(2072866..2078013) Lactococcus lactis subsp. cremoris MG1363 4798432 YP_001033345.1 CDS ps452 NC_009004.1 2078236 2078652 R phage tail component; High confidence in function and specificity; phage tail component complement(2078236..2078652) Lactococcus lactis subsp. cremoris MG1363 4796568 YP_001033346.1 CDS ps451 NC_009004.1 2078797 2079390 R Phage major tail protein; High confidence in function and specificity; phage major tail protein complement(2078797..2079390) Lactococcus lactis subsp. cremoris MG1363 4798240 YP_001033347.1 CDS ps450 NC_009004.1 2079421 2079816 R tail component protein; hypothetical protein complement(2079421..2079816) Lactococcus lactis subsp. cremoris MG1363 4798219 YP_001033348.1 CDS ps449 NC_009004.1 2079813 2080319 R Bacteriophage protein of unknown function DUF646; hypothetical protein complement(2079813..2080319) Lactococcus lactis subsp. cremoris MG1363 4796738 YP_001033349.1 CDS ps448 NC_009004.1 2080321 2080671 R hypothetical protein complement(2080321..2080671) Lactococcus lactis subsp. cremoris MG1363 4796993 YP_001033350.1 CDS ps447 NC_009004.1 2080646 2080969 R Uncharacterized phage protein (possible DNA packaging); hypothetical protein complement(2080646..2080969) Lactococcus lactis subsp. cremoris MG1363 4797144 YP_001033351.1 CDS ps446 NC_009004.1 2081170 2082384 R Phage major capsid protein, HK97 phage capsid family; High confidence in function and specificity; major head protein precursor complement(2081170..2082384) Lactococcus lactis subsp. cremoris MG1363 4798193 YP_001033352.1 CDS ps445 NC_009004.1 2082396 2083100 R Similar to ATP-dependent Clp protease proteolytic subunit; High confidence in function and specificity; hypothetical protein complement(2082396..2083100) Lactococcus lactis subsp. cremoris MG1363 4797092 YP_001033353.1 CDS ps444 NC_009004.1 2083146 2084318 R Phage portal protein, HK97 family; High confidence in function and specificity; phage portal protein complement(2083146..2084318) Lactococcus lactis subsp. cremoris MG1363 4797131 YP_001033354.1 CDS ps443 NC_009004.1 2084321 2084530 R Conserved hypothetical protein; head-tail joining protein complement(2084321..2084530) Lactococcus lactis subsp. cremoris MG1363 4796884 YP_001033355.1 CDS ps442 NC_009004.1 2084499 2086097 R Phage Terminase, large subunit; Conserved hypothetical protein; terminase large subunit complement(2084499..2086097) Lactococcus lactis subsp. cremoris MG1363 4798215 YP_001033356.1 CDS ps440 NC_009004.1 2087720 2088118 R phage terminase, small subunit, P27 family; phage terminase small subunit complement(2087720..2088118) Lactococcus lactis subsp. cremoris MG1363 4798025 YP_001033357.1 CDS ps439 NC_009004.1 2088300 2088818 R restriction endonuclease; hypothetical protein complement(2088300..2088818) Lactococcus lactis subsp. cremoris MG1363 4796987 YP_001033358.1 CDS ps438 NC_009004.1 2088822 2089112 R hypothetical protein complement(2088822..2089112) Lactococcus lactis subsp. cremoris MG1363 4798186 YP_001033359.1 CDS ps437 NC_009004.1 2089489 2089890 R Protein of unknown function DUF722; hypothetical protein complement(2089489..2089890) Lactococcus lactis subsp. cremoris MG1363 4796951 YP_001033360.1 CDS ps436 NC_009004.1 2089973 2090158 R Lambda repressor-like, DNA-binding protein; hypothetical protein complement(2089973..2090158) Lactococcus lactis subsp. cremoris MG1363 4797125 YP_001033361.1 CDS ps435 NC_009004.1 2090155 2090463 R hypothetical protein complement(2090155..2090463) Lactococcus lactis subsp. cremoris MG1363 4797139 YP_001033362.1 CDS ps434 NC_009004.1 2090646 2090819 R hypothetical protein complement(2090646..2090819) Lactococcus lactis subsp. cremoris MG1363 4797059 YP_001033363.1 CDS llmg_2109 NC_009004.1 2090895 2091653 R PF01695: IstB-like ATP-binding protein; Conserved hypothetical protein; transposase helper protein for IS712H complement(2090895..2091653) Lactococcus lactis subsp. cremoris MG1363 4797053 YP_001033364.1 CDS tnp712 NC_009004.1 2091665 2092888 R Conserved hypothetical protein; transposase for insertion sequence element IS712H complement(2091665..2092888) Lactococcus lactis subsp. cremoris MG1363 4797294 YP_001033365.1 CDS ps431 NC_009004.1 2093448 2093657 D hypothetical protein 2093448..2093657 Lactococcus lactis subsp. cremoris MG1363 4797571 YP_001033366.1 CDS ps430 NC_009004.1 2093903 2094133 R hypothetical protein complement(2093903..2094133) Lactococcus lactis subsp. cremoris MG1363 4797051 YP_001033367.1 CDS ps429 NC_009004.1 2094152 2094490 R Protein of unknown function DUF1140; hypothetical protein complement(2094152..2094490) Lactococcus lactis subsp. cremoris MG1363 4798153 YP_001033368.1 CDS ps428 NC_009004.1 2094491 2094910 R Deoxyuridine 5'-triphosphate nucleotidohydrolase; High confidence in function and specificity; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(2094491..2094910) Lactococcus lactis subsp. cremoris MG1363 4798157 YP_001033369.1 CDS ps427 NC_009004.1 2094907 2095464 R Protein of unknown function (DUF1642); hypothetical protein complement(2094907..2095464) Lactococcus lactis subsp. cremoris MG1363 4798499 YP_001033370.1 CDS ps426 NC_009004.1 2095480 2095716 R hypothetical protein complement(2095480..2095716) Lactococcus lactis subsp. cremoris MG1363 4796984 YP_001033371.1 CDS ps425 NC_009004.1 2095888 2096085 R hypothetical protein complement(2095888..2096085) Lactococcus lactis subsp. cremoris MG1363 4796838 YP_001033372.1 CDS ps424 NC_009004.1 2096086 2096352 R hypothetical protein complement(2096086..2096352) Lactococcus lactis subsp. cremoris MG1363 4797062 YP_001033373.1 CDS ps423 NC_009004.1 2096333 2096665 R hypothetical protein complement(2096333..2096665) Lactococcus lactis subsp. cremoris MG1363 4798228 YP_001033374.1 CDS ps422 NC_009004.1 2096680 2096964 R hypothetical protein complement(2096680..2096964) Lactococcus lactis subsp. cremoris MG1363 4797244 YP_001033375.1 CDS ps421 NC_009004.1 2096981 2097205 R hypothetical protein complement(2096981..2097205) Lactococcus lactis subsp. cremoris MG1363 4796608 YP_001033376.1 CDS ps420 NC_009004.1 2097312 2097551 R Protein of unknown function DUF1031; hypothetical protein complement(2097312..2097551) Lactococcus lactis subsp. cremoris MG1363 4796926 YP_001033377.1 CDS ps419 NC_009004.1 2097548 2097922 R Protein of unknown function DUF1064; hypothetical protein complement(2097548..2097922) Lactococcus lactis subsp. cremoris MG1363 4799104 YP_001033378.1 CDS ps418 NC_009004.1 2097919 2098644 R phage replication module protein; High confidence in function and specificity; hypothetical protein complement(2097919..2098644) Lactococcus lactis subsp. cremoris MG1363 4797286 YP_001033379.1 CDS ps417 NC_009004.1 2098644 2099426 R replisome organiser; High confidence in function and specificity; phage replication initiation protein complement(2098644..2099426) Lactococcus lactis subsp. cremoris MG1363 4796807 YP_001033380.1 CDS ps416 NC_009004.1 2099555 2099980 R Single-strand binding protein (SSB) (Helix- destabilizing protein); High confidence in function and specificity; single-strand binding protein ssB complement(2099555..2099980) Lactococcus lactis subsp. cremoris MG1363 4798574 YP_001033381.1 CDS llmg_2127 NC_009004.1 2099973 2100107 R C-terminal end of prophage protein. Frameshift upstream in N-terminal region (1st 123aa's) corresponding to next ORF automatically called; translation initiation factor complement(2099973..2100107) Lactococcus lactis subsp. cremoris MG1363 4798714 YP_001033382.1 CDS ps415 NC_009004.1 2100360 2100731 R translation initiation factor complement(2100360..2100731) Lactococcus lactis subsp. cremoris MG1363 4799100 YP_001033383.1 CDS ps414 NC_009004.1 2100740 2101135 R hypothetical protein complement(2100740..2101135) Lactococcus lactis subsp. cremoris MG1363 4798705 YP_001033384.1 CDS ps413 NC_009004.1 2101234 2101476 R hypothetical protein complement(2101234..2101476) Lactococcus lactis subsp. cremoris MG1363 4798699 YP_001033385.1 CDS ps412 NC_009004.1 2101482 2101961 D Conserved hypothetical protein; hypothetical protein 2101482..2101961 Lactococcus lactis subsp. cremoris MG1363 4798711 YP_001033386.1 CDS ps411 NC_009004.1 2101954 2102157 R hypothetical protein complement(2101954..2102157) Lactococcus lactis subsp. cremoris MG1363 4798716 YP_001033387.1 CDS ps410 NC_009004.1 2102253 2102522 R DNA binding protein; hypothetical protein complement(2102253..2102522) Lactococcus lactis subsp. cremoris MG1363 4798710 YP_001033388.1 CDS ps409 NC_009004.1 2102536 2103294 R Phage antirepressor protein; Conserved hypothetical protein; phage antirepressor protein complement(2102536..2103294) Lactococcus lactis subsp. cremoris MG1363 4798706 YP_001033389.1 CDS ps408 NC_009004.1 2103307 2103555 R Lambda repressor-like, DNA-binding, Helix-turn- helix motif, phage associated; Cro repressor complement(2103307..2103555) Lactococcus lactis subsp. cremoris MG1363 4796621 YP_001033390.1 CDS ps407 NC_009004.1 2103660 2103896 D phage associated; hypothetical protein 2103660..2103896 Lactococcus lactis subsp. cremoris MG1363 4796793 YP_001033391.1 CDS ps406 NC_009004.1 2103868 2104089 R phage associated; hypothetical protein complement(2103868..2104089) Lactococcus lactis subsp. cremoris MG1363 4796741 YP_001033392.1 CDS ps405 NC_009004.1 2104187 2104300 D phage associated; hypothetical protein 2104187..2104300 Lactococcus lactis subsp. cremoris MG1363 4798545 YP_001033393.1 CDS ps404 NC_009004.1 2104945 2105442 D DNA-binding transcriptional regulator, Phage associated; High confidence in function and specificity; cI-like repressor 2104945..2105442 Lactococcus lactis subsp. cremoris MG1363 4796837 YP_001033394.1 CDS ps403 NC_009004.1 2105448 2105882 D phage associated; hypothetical protein 2105448..2105882 Lactococcus lactis subsp. cremoris MG1363 4799010 YP_001033395.1 CDS ps402 NC_009004.1 2105896 2106231 D Phage associated; hypothetical protein 2105896..2106231 Lactococcus lactis subsp. cremoris MG1363 4798725 YP_001033396.1 CDS ps401 NC_009004.1 2106266 2107480 D Phage integrase; High confidence in function and specificity; phage integrase 2106266..2107480 Lactococcus lactis subsp. cremoris MG1363 4796844 YP_001033397.1 CDS llmg_2143 NC_009004.1 2107775 2108281 R Protein of unknown function DUF322, Protein of unknown function (DUF322); Conserved hypothetical protein; 20-kDa protein complement(2107775..2108281) Lactococcus lactis subsp. cremoris MG1363 4799108 YP_001033398.1 CDS llmg_2144 NC_009004.1 2108291 2108479 R hypothetical protein complement(2108291..2108479) Lactococcus lactis subsp. cremoris MG1363 4799124 YP_001033399.1 CDS llmg_2145 NC_009004.1 2108490 2109050 R --; hypothetical protein complement(2108490..2109050) Lactococcus lactis subsp. cremoris MG1363 4799126 YP_001033400.1 CDS llmg_2146 NC_009004.1 2109078 2109320 R -; hypothetical protein complement(2109078..2109320) Lactococcus lactis subsp. cremoris MG1363 4799115 YP_001033401.1 CDS fmt NC_009004.1 2109555 2110526 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(2109555..2110526) Lactococcus lactis subsp. cremoris MG1363 4799113 YP_001033402.1 CDS llmg_2148 NC_009004.1 2110523 2110987 R 3-demethylubiquinone-9 3-methyltransferase; hypothetical protein complement(2110523..2110987) Lactococcus lactis subsp. cremoris MG1363 4798490 YP_001033403.1 CDS llmg_2149 NC_009004.1 2110953 2111474 R NUDIX hydrolase; Conserved hypothetical protein; Nudix hydrolase complement(2110953..2111474) Lactococcus lactis subsp. cremoris MG1363 4797124 YP_001033404.1 CDS llmg_2150 NC_009004.1 2111488 2111862 R hypothetical protein complement(2111488..2111862) Lactococcus lactis subsp. cremoris MG1363 4797054 YP_001033405.1 CDS llmg_2151 NC_009004.1 2111849 2112595 R Conserved hypothetical protein; hypothetical protein complement(2111849..2112595) Lactococcus lactis subsp. cremoris MG1363 4796575 YP_001033406.1 CDS llmg_2152 NC_009004.1 2112728 2113069 R Conserved hypothetical protein; hypothetical protein complement(2112728..2113069) Lactococcus lactis subsp. cremoris MG1363 4797042 YP_001033407.1 CDS priA NC_009004.1 2113093 2115438 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(2113093..2115438) Lactococcus lactis subsp. cremoris MG1363 4797106 YP_001033408.1 CDS rpoZ NC_009004.1 2115615 2115968 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(2115615..2115968) Lactococcus lactis subsp. cremoris MG1363 4796949 YP_001033409.1 CDS gmk NC_009004.1 2116037 2116654 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(2116037..2116654) Lactococcus lactis subsp. cremoris MG1363 4797566 YP_001033410.1 CDS llmg_2156 NC_009004.1 2116803 2118398 R protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP; phosphodiesterase complement(2116803..2118398) Lactococcus lactis subsp. cremoris MG1363 4797527 YP_001033411.1 CDS nagB2 NC_009004.1 2118632 2119345 R Glucosamine-6-phosphate deaminase; High confidence in function and specificity; 6-phosphogluconolactonase complement(2118632..2119345) Lactococcus lactis subsp. cremoris MG1363 4796882 YP_001033412.1 CDS llmg_2158 NC_009004.1 2119449 2119541 R duplication of the C-terminal end of metK; hypothetical protein complement(2119449..2119541) Lactococcus lactis subsp. cremoris MG1363 4797026 YP_001033413.1 CDS llmg_2159 NC_009004.1 2119619 2119711 R duplication of the C-terminal end of metK; hypothetical protein complement(2119619..2119711) Lactococcus lactis subsp. cremoris MG1363 4798112 YP_001033414.1 CDS metK NC_009004.1 2119789 2120988 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(2119789..2120988) Lactococcus lactis subsp. cremoris MG1363 4798180 YP_001033415.1 CDS cfa NC_009004.1 2121533 2122726 R cyclopropane-fatty-acyl-phospholipid synthase complement(2121533..2122726) Lactococcus lactis subsp. cremoris MG1363 4798893 YP_001033416.1 CDS birA2 NC_009004.1 2122883 2123635 D BirA bifunctional protein; High confidence in function and specificity; acetyl-CoA carboxylase ligase / biotin operon repressor bifunctional protein 2122883..2123635 Lactococcus lactis subsp. cremoris MG1363 4799099 YP_001033417.1 CDS llmg_2163 NC_009004.1 2123763 2124227 R contains PspC domain; hypothetical protein complement(2123763..2124227) Lactococcus lactis subsp. cremoris MG1363 4798831 YP_001033418.1 CDS llmg_2164 NC_009004.1 2124563 2125675 R hypothetical protein complement(2124563..2125675) Lactococcus lactis subsp. cremoris MG1363 4797034 YP_001033419.1 CDS acmB NC_009004.1 2125886 2127502 R peptidoglycan hydrolase; High confidence in function and specificity; N-acetylmuramoyl-L-alanine amidase complement(2125886..2127502) Lactococcus lactis subsp. cremoris MG1363 4797015 YP_001033420.1 CDS fbaA NC_009004.1 2129181 2130077 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(2129181..2130077) Lactococcus lactis subsp. cremoris MG1363 4798307 YP_001033421.1 CDS llmg_2168 NC_009004.1 2136110 2136769 R Protein of unknown function; Conserved hypothetical protein; hypothetical protein complement(2136110..2136769) Lactococcus lactis subsp. cremoris MG1363 4797444 YP_001033422.1 CDS thrS NC_009004.1 2136874 2138814 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(2136874..2138814) Lactococcus lactis subsp. cremoris MG1363 4796964 YP_001033423.1 CDS llmg_2170 NC_009004.1 2139513 2139830 R High confidence in function and specificity; ribonucleoside-diphosphate reductase complement(2139513..2139830) Lactococcus lactis subsp. cremoris MG1363 4797584 YP_001033424.1 CDS mntA NC_009004.1 2139888 2141150 R High confidence in function and specificity; Mn and Fe transporters complement(2139888..2141150) Lactococcus lactis subsp. cremoris MG1363 4796927 YP_001033425.1 CDS llmg_2172 NC_009004.1 2141256 2141864 R Conserved hypothetical protein; nitroreductase complement(2141256..2141864) Lactococcus lactis subsp. cremoris MG1363 4797481 YP_001033426.1 CDS llmg_2173 NC_009004.1 2142091 2142381 D Conserved hypothetical protein; hypothetical protein 2142091..2142381 Lactococcus lactis subsp. cremoris MG1363 4796903 YP_001033427.1 CDS tnp904 NC_009004.1 2142477 2143238 D Conserved hypothetical protein; transposase for insertion sequence element IS904I 2142477..2143238 Lactococcus lactis subsp. cremoris MG1363 4796744 YP_001033428.1 CDS llmg_2175 NC_009004.1 2144101 2144670 R Function unclear; hypothetical protein complement(2144101..2144670) Lactococcus lactis subsp. cremoris MG1363 4797003 YP_001033429.1 CDS upp NC_009004.1 2144746 2145381 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2144746..2145381) Lactococcus lactis subsp. cremoris MG1363 4797268 YP_001033430.1 CDS nah NC_009004.1 2145583 2146722 R Sodium/hydrogen exchanger family; High confidence in function and specificity; Na+/H+ antiporter complement(2145583..2146722) Lactococcus lactis subsp. cremoris MG1363 4797164 YP_001033431.1 CDS metB1 NC_009004.1 2148432 2149520 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(2148432..2149520) Lactococcus lactis subsp. cremoris MG1363 4798149 YP_001033432.1 CDS metA NC_009004.1 2149551 2150510 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(2149551..2150510) Lactococcus lactis subsp. cremoris MG1363 4796856 YP_001033433.1 CDS llmg_2183 NC_009004.1 2150648 2151205 R hypothetical protein complement(2150648..2151205) Lactococcus lactis subsp. cremoris MG1363 4797454 YP_001033434.1 CDS llmg_2184 NC_009004.1 2151214 2152122 R hypothetical protein complement(2151214..2152122) Lactococcus lactis subsp. cremoris MG1363 4797166 YP_001033435.1 CDS lacX NC_009004.1 2152257 2153126 R Galactose mutarotase-like, Aldose 1-epimerase; galactose mutarotase related enzyme complement(2152257..2153126) Lactococcus lactis subsp. cremoris MG1363 4798297 YP_001033436.1 CDS cbf NC_009004.1 2153217 2154161 R Metal-dependent phosphohydrolase, HD subdomain; Conserved hypothetical protein; CMP-binding factor complement(2153217..2154161) Lactococcus lactis subsp. cremoris MG1363 4797654 YP_001033437.1 CDS llmg_2187 NC_009004.1 2154235 2155533 R Protein of unknown function DUF195, RmuC family; hypothetical protein complement(2154235..2155533) Lactococcus lactis subsp. cremoris MG1363 4797648 YP_001033438.1 CDS llmg_2188 NC_009004.1 2155543 2155812 R hypothetical protein complement(2155543..2155812) Lactococcus lactis subsp. cremoris MG1363 4798612 YP_001033439.1 CDS tmrB NC_009004.1 2155879 2156052 R Conserved hypothetical protein; tunicamycin resistance protein complement(2155879..2156052) Lactococcus lactis subsp. cremoris MG1363 4797188 YP_001033440.1 CDS rpe NC_009004.1 2156049 2156711 R Ribulose-phosphate 3-epimerase; High confidence in function and specificity; ribulose-phosphate 3-epimerase complement(2156049..2156711) Lactococcus lactis subsp. cremoris MG1363 4796920 YP_001033441.1 CDS llmg_2191 NC_009004.1 2156785 2157042 R hypothetical protein complement(2156785..2157042) Lactococcus lactis subsp. cremoris MG1363 4797291 YP_001033442.1 CDS llmg_2192 NC_009004.1 2157039 2157293 R hypothetical protein complement(2157039..2157293) Lactococcus lactis subsp. cremoris MG1363 4798510 YP_001033443.1 CDS llmg_2193 NC_009004.1 2157265 2158188 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(2157265..2158188) Lactococcus lactis subsp. cremoris MG1363 4798051 YP_001033444.1 CDS llmg_2194 NC_009004.1 2158249 2159322 R Region start changed from 2159382 to 2159322 (-60 bases); hypothetical protein complement(2158249..2159322) Lactococcus lactis subsp. cremoris MG1363 4798120 YP_001033445.1 CDS pheT NC_009004.1 2159623 2162016 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(2159623..2162016) Lactococcus lactis subsp. cremoris MG1363 4799009 YP_001033446.1 CDS pheS NC_009004.1 2162127 2163164 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(2162127..2163164) Lactococcus lactis subsp. cremoris MG1363 4798544 YP_001033447.1 CDS padC NC_009004.1 2163648 2164103 D Probable phenolic acid decarboxylase; High confidence in function and specificity; PadC protein 2163648..2164103 Lactococcus lactis subsp. cremoris MG1363 4797867 YP_001033448.1 CDS padR NC_009004.1 2164419 2164958 D Transcriptional regulator PadR-like; transcriptional repressor of padC 2164419..2164958 Lactococcus lactis subsp. cremoris MG1363 4799074 YP_001033449.1 CDS chiC NC_009004.1 2165127 2166605 D Chitinase II, Glycosyl hydrolases family 18; Conserved hypothetical protein; acidic endochitinase precursor 2165127..2166605 Lactococcus lactis subsp. cremoris MG1363 4799073 YP_001033450.1 CDS chb NC_009004.1 2166626 2167288 D Chitin-binding, domain 3; chitin binding protein 2166626..2167288 Lactococcus lactis subsp. cremoris MG1363 4797027 YP_001033451.1 CDS purA NC_009004.1 2167331 2168623 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(2167331..2168623) Lactococcus lactis subsp. cremoris MG1363 4796977 YP_001033452.1 CDS llmg_2202 NC_009004.1 2168798 2168911 R hypothetical protein complement(2168798..2168911) Lactococcus lactis subsp. cremoris MG1363 4797731 YP_001033453.1 CDS cadD NC_009004.1 2168989 2169600 R cadmium resistance transporter family protein; cadmium resistance protein complement(2168989..2169600) Lactococcus lactis subsp. cremoris MG1363 4798254 YP_001033454.1 CDS hslO NC_009004.1 2169764 2170630 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2169764..2170630 Lactococcus lactis subsp. cremoris MG1363 4797626 YP_001033455.1 CDS llmg_2205 NC_009004.1 2170685 2171206 D Bacterial bifunctional deaminase-reductase, C- terminal; dihydrofolate reductase 2170685..2171206 Lactococcus lactis subsp. cremoris MG1363 4796618 YP_001033456.1 CDS llmg_2206 NC_009004.1 2171541 2172818 D hypothetical protein 2171541..2172818 Lactococcus lactis subsp. cremoris MG1363 4798075 YP_001033457.1 CDS llmg_2207 NC_009004.1 2172828 2173400 D hypothetical protein 2172828..2173400 Lactococcus lactis subsp. cremoris MG1363 4798475 YP_001033458.1 CDS llmg_2208 NC_009004.1 2173443 2173835 D hypothetical protein 2173443..2173835 Lactococcus lactis subsp. cremoris MG1363 4797190 YP_001033459.1 CDS llmg_2209 NC_009004.1 2173947 2174951 D Dihydrouridine synthase TIM-barrel protein nifR3; Conserved hypothetical protein; tRNA-dihydrouridine synthase B 2173947..2174951 Lactococcus lactis subsp. cremoris MG1363 4798097 YP_001033460.1 CDS llmg_2210 NC_009004.1 2175017 2175109 D hypothetical protein 2175017..2175109 Lactococcus lactis subsp. cremoris MG1363 4798408 YP_001033461.1 CDS llmg_2211 NC_009004.1 2175267 2175497 D hypothetical protein 2175267..2175497 Lactococcus lactis subsp. cremoris MG1363 4798615 YP_001033462.1 CDS llmg_2212 NC_009004.1 2175537 2176421 R Protein of unknown function DUF161; hypothetical protein complement(2175537..2176421) Lactococcus lactis subsp. cremoris MG1363 4798740 YP_001033463.1 CDS llmg_2213 NC_009004.1 2176572 2177447 R Protein of unknown function DUF161; hypothetical protein complement(2176572..2177447) Lactococcus lactis subsp. cremoris MG1363 4798953 YP_001033464.1 CDS llmg_2214 NC_009004.1 2177551 2178480 R Protein of unknown function DUF161; hypothetical protein complement(2177551..2178480) Lactococcus lactis subsp. cremoris MG1363 4798604 YP_001033465.1 CDS aspS NC_009004.1 2178461 2180233 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2178461..2180233) Lactococcus lactis subsp. cremoris MG1363 4798611 YP_001033466.1 CDS llmg_2216 NC_009004.1 2180297 2180665 R Hypothetical 12.4 kDa HIT-like protein in PSBAII 5'region (ORF 1); High confidence in function and specificity; cell-cycle regulation histidine triad protein complement(2180297..2180665) Lactococcus lactis subsp. cremoris MG1363 4798409 YP_001033467.1 CDS hisS NC_009004.1 2180691 2181983 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2180691..2181983) Lactococcus lactis subsp. cremoris MG1363 4798614 YP_001033468.1 CDS llmg_2218 NC_009004.1 2182296 2183456 R Transcriptional activator Rgg/GadR/MutR, C- terminal; hypothetical protein complement(2182296..2183456) Lactococcus lactis subsp. cremoris MG1363 4796650 YP_001033469.1 CDS llmg_2219 NC_009004.1 2183700 2184023 R Region start changed from 2184026 to 2184023 (-3 bases); hypothetical protein complement(2183700..2184023) Lactococcus lactis subsp. cremoris MG1363 4797542 YP_001033470.1 CDS llmg_2220 NC_009004.1 2184088 2184165 R Region start changed from 2184420 to 2184165 (-255 bases); hypothetical protein complement(2184088..2184165) Lactococcus lactis subsp. cremoris MG1363 4797552 YP_001033471.1 CDS llmg_2221 NC_009004.1 2184552 2184896 R Region start changed from 2184947 to 2184896 (-51 bases); hypothetical protein complement(2184552..2184896) Lactococcus lactis subsp. cremoris MG1363 4797559 YP_001033472.1 CDS llmg_2222 NC_009004.1 2185006 2185329 R Region start changed from 2185332 to 2185329 (-3 bases); hypothetical protein complement(2185006..2185329) Lactococcus lactis subsp. cremoris MG1363 4797560 YP_001033473.1 CDS llmg_2223 NC_009004.1 2185333 2186193 R hypothetical protein complement(2185333..2186193) Lactococcus lactis subsp. cremoris MG1363 4797586 YP_001033474.1 CDS pgsA NC_009004.1 2186432 2187004 R High confidence in function and specificity; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2186432..2187004) Lactococcus lactis subsp. cremoris MG1363 4797595 YP_001033475.1 CDS llmg_2225 NC_009004.1 2187046 2187942 R Lambda repressor-like, DNA-binding; hypothetical protein complement(2187046..2187942) Lactococcus lactis subsp. cremoris MG1363 4798380 YP_001033476.1 CDS llmg_2226 NC_009004.1 2188155 2189438 R High confidence in function and specificity; M16 family peptidase complement(2188155..2189438) Lactococcus lactis subsp. cremoris MG1363 4798338 YP_001033477.1 CDS llmg_2227 NC_009004.1 2189428 2190714 R High confidence in function and specificity; hypothetical protein complement(2189428..2190714) Lactococcus lactis subsp. cremoris MG1363 4798343 YP_001033478.1 CDS llmg_2228 NC_009004.1 2190912 2191274 D RNA-binding S4; hypothetical protein 2190912..2191274 Lactococcus lactis subsp. cremoris MG1363 4798660 YP_001033479.1 CDS recF NC_009004.1 2191274 2192353 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2191274..2192353 Lactococcus lactis subsp. cremoris MG1363 4797336 YP_001033480.1 CDS pcaC NC_009004.1 2192458 2192826 R Carboxymuconolactone decarboxylase; High confidence in function and specificity; gamma-carboxymuconolactone decarboxylase complement(2192458..2192826) Lactococcus lactis subsp. cremoris MG1363 4796697 YP_001033481.1 CDS rmeD NC_009004.1 2192903 2193280 D DNA binding; Conserved hypothetical protein; MerR family transcriptional regulator 2192903..2193280 Lactococcus lactis subsp. cremoris MG1363 4798143 YP_001033482.1 CDS llmg_2232 NC_009004.1 2193297 2194262 R Bacterial protein of unknown function (DUF915); hypothetical protein complement(2193297..2194262) Lactococcus lactis subsp. cremoris MG1363 4797813 YP_001033483.1 CDS galE NC_009004.1 2194374 2195354 R NAD dependent epimerase/dehydratase; High confidence in function and specificity; GalE protein complement(2194374..2195354) Lactococcus lactis subsp. cremoris MG1363 4798346 YP_001033484.1 CDS galT NC_009004.1 2195471 2196952 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(2195471..2196952) Lactococcus lactis subsp. cremoris MG1363 4799060 YP_001033485.1 CDS galK NC_009004.1 2197125 2198324 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(2197125..2198324) Lactococcus lactis subsp. cremoris MG1363 4797662 YP_001033486.1 CDS galM NC_009004.1 2198351 2199370 R Galactose mutarotase-like; High confidence in function and specificity; aldose 1-epimerase complement(2198351..2199370) Lactococcus lactis subsp. cremoris MG1363 4797632 YP_001033487.1 CDS galP NC_009004.1 2199576 2200964 R Sodium:galactoside symporter; Conserved hypothetical protein; galactose permease complement(2199576..2200964) Lactococcus lactis subsp. cremoris MG1363 4797641 YP_001033488.1 CDS llmg_2238 NC_009004.1 2201271 2202023 R transcriptional regulator, PF01380: Sugar isomerase (SIS domain); hypothetical protein complement(2201271..2202023) Lactococcus lactis subsp. cremoris MG1363 4797651 YP_001033489.1 CDS nadR NC_009004.1 2203231 2204370 R IPR006417 Nicotinamide-nucleotide adenylyltransferase, TIGR01526: nicotinamide-nucleotide adenylyltransferase, no DNA binding HTH-motif; Conserved hypothetical protein; nicotinamide-nucleotide adenylyltransferase complement(2203231..2204370) Lactococcus lactis subsp. cremoris MG1363 4798095 YP_001033490.1 CDS llmg_2242 NC_009004.1 2204357 2205334 R PF02826: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Family membership; hypothetical protein complement(2204357..2205334) Lactococcus lactis subsp. cremoris MG1363 4798500 YP_001033491.1 CDS llmg_2243 NC_009004.1 2205532 2206824 R PF01136: Peptidase U32, protease; hypothetical protein complement(2205532..2206824) Lactococcus lactis subsp. cremoris MG1363 4797532 YP_001033492.1 CDS llmg_2244 NC_009004.1 2207148 2208119 R PF01136: Peptidase U32, protease; hypothetical protein complement(2207148..2208119) Lactococcus lactis subsp. cremoris MG1363 4797523 YP_001033493.1 CDS llmg_2245 NC_009004.1 2208291 2208572 D hypothetical protein 2208291..2208572 Lactococcus lactis subsp. cremoris MG1363 4798876 YP_001033494.1 CDS rrmA NC_009004.1 2208602 2209423 R Conserved hypothetical protein; rRNA (guanine-N1-)-methyltransferase complement(2208602..2209423) Lactococcus lactis subsp. cremoris MG1363 4798888 YP_001033495.1 CDS llmg_2247 NC_009004.1 2210138 2210863 R hypothetical protein complement(2210138..2210863) Lactococcus lactis subsp. cremoris MG1363 4798381 YP_001033496.1 CDS llmg_2248 NC_009004.1 2210856 2212178 R Hypothetical phage protein; abortive phage resistance complement(2210856..2212178) Lactococcus lactis subsp. cremoris MG1363 4798898 YP_001033497.1 CDS llmg_2249 NC_009004.1 2212625 2212957 R hypothetical protein complement(2212625..2212957) Lactococcus lactis subsp. cremoris MG1363 4798912 YP_001033498.1 CDS ps519 NC_009004.1 2212957 2213397 R PF03592: Terminase small subunit; Conserved hypothetical protein; terminase small subunit complement(2212957..2213397) Lactococcus lactis subsp. cremoris MG1363 4798923 YP_001033499.1 CDS ps518 NC_009004.1 2213530 2214072 R phage protein by Glimmer/Critica complement(2213530..2214072) Lactococcus lactis subsp. cremoris MG1363 4798309 YP_001033500.1 CDS ps517 NC_009004.1 2214289 2215917 R Conserved hypothetical protein; DNA primase complement(2214289..2215917) Lactococcus lactis subsp. cremoris MG1363 4798311 YP_001033501.1 CDS ps516 NC_009004.1 2215928 2216722 R phage protein by Glimmer/Critica complement(2215928..2216722) Lactococcus lactis subsp. cremoris MG1363 4798026 YP_001033502.1 CDS ps515 NC_009004.1 2216719 2217054 R phage protein by Glimmer/Critica complement(2216719..2217054) Lactococcus lactis subsp. cremoris MG1363 4797287 YP_001033503.1 CDS ps514 NC_009004.1 2217124 2217363 R phage protein by Glimmer/Critica complement(2217124..2217363) Lactococcus lactis subsp. cremoris MG1363 4797174 YP_001033504.1 CDS ps513 NC_009004.1 2217401 2217682 R hypothetical protein complement(2217401..2217682) Lactococcus lactis subsp. cremoris MG1363 4797176 YP_001033505.1 CDS ps512 NC_009004.1 2217675 2217800 R hypothetical protein complement(2217675..2217800) Lactococcus lactis subsp. cremoris MG1363 4797192 YP_001033506.1 CDS ps511 NC_009004.1 2217816 2217911 R hypothetical protein complement(2217816..2217911) Lactococcus lactis subsp. cremoris MG1363 4797814 YP_001033507.1 CDS ps510 NC_009004.1 2217904 2218107 R hypothetical protein complement(2217904..2218107) Lactococcus lactis subsp. cremoris MG1363 4797822 YP_001033508.1 CDS ps509 NC_009004.1 2218104 2218625 R phage protein by Glimmer/Critica complement(2218104..2218625) Lactococcus lactis subsp. cremoris MG1363 4797821 YP_001033509.1 CDS ps508 NC_009004.1 2218884 2219549 R phage protein by Glimmer/Critica complement(2218884..2219549) Lactococcus lactis subsp. cremoris MG1363 4798030 YP_001033510.1 CDS ps507 NC_009004.1 2220104 2220646 D bacteriophage repressor, PF01381: Helix- turn-helix , IPR010982: Lambda repressor-like, DNA- binding; hypothetical protein 2220104..2220646 Lactococcus lactis subsp. cremoris MG1363 4798004 YP_001033511.1 CDS ps506 NC_009004.1 2221547 2222281 D hypothetical protein 2221547..2222281 Lactococcus lactis subsp. cremoris MG1363 4797907 YP_001033512.1 CDS ps505 NC_009004.1 2222487 2222672 D hypothetical protein 2222487..2222672 Lactococcus lactis subsp. cremoris MG1363 4797828 YP_001033513.1 CDS ps504 NC_009004.1 2222859 2223923 D hypothetical protein 2222859..2223923 Lactococcus lactis subsp. cremoris MG1363 4797301 YP_001033514.1 CDS ps503 NC_009004.1 2224575 2224889 D hypothetical protein 2224575..2224889 Lactococcus lactis subsp. cremoris MG1363 4797156 YP_001033515.1 CDS ps502 NC_009004.1 2225693 2225887 D hypothetical protein 2225693..2225887 Lactococcus lactis subsp. cremoris MG1363 4798505 YP_001033516.1 CDS ps501 NC_009004.1 2226384 2227565 D PF00589: Phage integrase; Conserved hypothetical protein; phage integrase 2226384..2227565 Lactococcus lactis subsp. cremoris MG1363 4798002 YP_001033517.1 CDS cutC NC_009004.1 2227778 2228404 D PF03932: CutC family; Conserved hypothetical protein; copper homeostasis protein cutC 2227778..2228404 Lactococcus lactis subsp. cremoris MG1363 4798260 YP_001033518.1 CDS ecsB NC_009004.1 2228437 2229456 R PF05975: Bacterial ABC transporter protein EcsB; Family membership; ABC transporter ATP-binding protein complement(2228437..2229456) Lactococcus lactis subsp. cremoris MG1363 4798847 YP_001033519.1 CDS ecsA NC_009004.1 2229449 2230219 R PF00005: ABC transporter; Conserved hypothetical protein; ABC transporter ATP-binding protein complement(2229449..2230219) Lactococcus lactis subsp. cremoris MG1363 4798619 YP_001033520.1 CDS llmg_2272 NC_009004.1 2230238 2232016 R IPR004129: Glycerophosphoryl diester phosphodiesterase , Glycerophosphoryl diester phosphodiesterase; hypothetical protein complement(2230238..2232016) Lactococcus lactis subsp. cremoris MG1363 4797563 YP_001033521.1 CDS llmg_2273 NC_009004.1 2232315 2232713 D Histidine triad protein, PF01230: HIT domain; hypothetical protein 2232315..2232713 Lactococcus lactis subsp. cremoris MG1363 4798540 YP_001033522.1 CDS llmg_2274 NC_009004.1 2232728 2232949 D hypothetical protein 2232728..2232949 Lactococcus lactis subsp. cremoris MG1363 4796651 YP_001033523.1 CDS llmg_2275 NC_009004.1 2232961 2233320 R membrane protein; hypothetical protein complement(2232961..2233320) Lactococcus lactis subsp. cremoris MG1363 4796579 YP_001033524.1 CDS rplA NC_009004.1 2233383 2234072 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(2233383..2234072) Lactococcus lactis subsp. cremoris MG1363 4796746 YP_001033525.1 CDS rplK NC_009004.1 2234459 2234884 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(2234459..2234884) Lactococcus lactis subsp. cremoris MG1363 4798439 YP_001033526.1 CDS llmg_2278 NC_009004.1 2235020 2235784 R membrane protein; hypothetical protein complement(2235020..2235784) Lactococcus lactis subsp. cremoris MG1363 4797915 YP_001033527.1 CDS bcrA NC_009004.1 2235784 2236662 R PF00005: ABC transporter; Conserved hypothetical protein; bacitracin transport ATP-binding protein complement(2235784..2236662) Lactococcus lactis subsp. cremoris MG1363 4798106 YP_001033528.1 CDS llmg_2280 NC_009004.1 2236729 2236938 R PF06855: Protein of unknown function DUF1250; hypothetical protein complement(2236729..2236938) Lactococcus lactis subsp. cremoris MG1363 4798648 YP_001033529.1 CDS pmsR NC_009004.1 2236972 2237493 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(2236972..2237493) Lactococcus lactis subsp. cremoris MG1363 4796673 YP_001033530.1 CDS llmg_2282 NC_009004.1 2237669 2238526 R IPR008994: Nucleic acid-binding, OB-fold; hypothetical protein complement(2237669..2238526) Lactococcus lactis subsp. cremoris MG1363 4797834 YP_001033531.1 CDS llmg_2283 NC_009004.1 2238571 2239029 R GNAT family acetyltransferase, PF00583: Acetyltransferase (GNAT) family; hypothetical protein complement(2238571..2239029) Lactococcus lactis subsp. cremoris MG1363 4796652 YP_001033532.1 CDS frr NC_009004.1 2239114 2239671 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(2239114..2239671) Lactococcus lactis subsp. cremoris MG1363 4796622 YP_001033533.1 CDS pyrH NC_009004.1 2239828 2240544 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(2239828..2240544) Lactococcus lactis subsp. cremoris MG1363 4798942 YP_001033534.1 CDS llmg_2286 NC_009004.1 2240629 2241081 R hypothetical protein complement(2240629..2241081) Lactococcus lactis subsp. cremoris MG1363 4797541 YP_001033535.1 CDS ackA2 NC_009004.1 2241211 2242398 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(2241211..2242398) Lactococcus lactis subsp. cremoris MG1363 4796749 YP_001033536.1 CDS ackA1 NC_009004.1 2242557 2243744 R PF00871: Acetokinase, TIGR00016: acetate kinase; High confidence in function and specificity; AckA1 protein complement(2242557..2243744) Lactococcus lactis subsp. cremoris MG1363 4798785 YP_001033537.1 CDS llmg_2290 NC_009004.1 2243936 2244874 R IPR000051: SAM (and some other nucleotide) binding motif; hypothetical protein complement(2243936..2244874) Lactococcus lactis subsp. cremoris MG1363 4798772 YP_001033538.1 CDS llmg_2291 NC_009004.1 2244962 2245213 R membrane protein; hypothetical protein complement(2244962..2245213) Lactococcus lactis subsp. cremoris MG1363 4796693 YP_001033539.1 CDS typA NC_009004.1 2245314 2247155 R PF00009: Elongation factor Tu GTP binding domain, TIGR01394: GTP-binding protein TypA; Conserved hypothetical protein; GTP-binding protein TypA complement(2245314..2247155) Lactococcus lactis subsp. cremoris MG1363 4796711 YP_001033540.1 CDS llmg_2293 NC_009004.1 2247824 2248228 R hypothetical protein complement(2247824..2248228) Lactococcus lactis subsp. cremoris MG1363 4798103 YP_001033541.1 CDS llmg_2294 NC_009004.1 2248240 2248698 R membrane protein; hypothetical protein complement(2248240..2248698) Lactococcus lactis subsp. cremoris MG1363 4796571 YP_001033542.1 CDS llmg_2295 NC_009004.1 2248713 2249486 R secreted protein; hypothetical protein complement(2248713..2249486) Lactococcus lactis subsp. cremoris MG1363 4796667 YP_001033543.1 CDS llmg_2297 NC_009004.1 2249826 2250554 R PF04397: LytTr DNA-binding region; hypothetical protein complement(2249826..2250554) Lactococcus lactis subsp. cremoris MG1363 4797785 YP_001033544.1 CDS llmg_2298 NC_009004.1 2250747 2250968 D PF06014: Bacterial protein of unknown function (DUF910); hypothetical protein 2250747..2250968 Lactococcus lactis subsp. cremoris MG1363 4798426 YP_001033545.1 CDS glk NC_009004.1 2251002 2251973 D PF00480: ROK family, TIGR00744: ROK family protein ( glucokinase); High confidence in function and specificity; glucokinase 2251002..2251973 Lactococcus lactis subsp. cremoris MG1363 4799138 YP_001033546.1 CDS llmg_2300 NC_009004.1 2251976 2252362 D PF00581: Rhodanese-like domain; hypothetical protein 2251976..2252362 Lactococcus lactis subsp. cremoris MG1363 4797959 YP_001033547.1 CDS llmg_2301 NC_009004.1 2252332 2252436 D hypothetical protein 2252332..2252436 Lactococcus lactis subsp. cremoris MG1363 4796600 YP_001033548.1 CDS dpsA NC_009004.1 2252478 2252924 R PF00210: Ferritin-like domain; High confidence in function and specificity; non-heme iron-binding ferritin complement(2252478..2252924) Lactococcus lactis subsp. cremoris MG1363 4798207 YP_001033549.1 CDS comC NC_009004.1 2253090 2253755 D PF01478: Peptidase A24A, prepilin type IV, PF06750: Bacterial Peptidase A24 N-terminal domain; High confidence in function and specificity; type 4 prepilin-like protein specific leader peptidase 2253090..2253755 Lactococcus lactis subsp. cremoris MG1363 4798371 YP_001033550.1 CDS dinP NC_009004.1 2253706 2254800 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(2253706..2254800) Lactococcus lactis subsp. cremoris MG1363 4799035 YP_001033551.1 CDS llmg_2306 NC_009004.1 2254876 2255367 R IPR007214: YbaK/prolyl-tRNA synthetase associated region; hypothetical protein complement(2254876..2255367) Lactococcus lactis subsp. cremoris MG1363 4798914 YP_001033552.1 CDS arcD2 NC_009004.1 2255443 2256936 R PF00324: Amino acid permease-associated region, TIGR00905: arginine/ornithine antiporter; Conserved hypothetical protein; arginine/ornithine antiporter complement(2255443..2256936) Lactococcus lactis subsp. cremoris MG1363 4798160 YP_001033553.1 CDS arcT NC_009004.1 2257126 2258256 R associated with arginine deiminase pathway genes; probably functions in arginine catabolism; transaminase complement(2257126..2258256) Lactococcus lactis subsp. cremoris MG1363 4796869 YP_001033554.1 CDS arcC2 NC_009004.1 2258520 2259464 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(2258520..2259464) Lactococcus lactis subsp. cremoris MG1363 4796870 YP_001033555.1 CDS arcC1 NC_009004.1 2259497 2260441 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(2259497..2260441) Lactococcus lactis subsp. cremoris MG1363 4797220 YP_001033556.1 CDS arcD1 NC_009004.1 2260459 2262039 R PF00324:Amino acid permease-associated region, TIGR00905: arginine/ornithine antiporter; High confidence in function and specificity; arginine/ornithine antiporter complement(2260459..2262039) Lactococcus lactis subsp. cremoris MG1363 4797572 YP_001033557.1 CDS arcB NC_009004.1 2262171 2263235 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(2262171..2263235) Lactococcus lactis subsp. cremoris MG1363 4796868 YP_001033558.1 CDS arcA NC_009004.1 2263401 2264633 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(2263401..2264633) Lactococcus lactis subsp. cremoris MG1363 4798543 YP_001033559.1 CDS argS NC_009004.1 2264934 2266628 R catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase complement(2264934..2266628) Lactococcus lactis subsp. cremoris MG1363 4797819 YP_001033560.1 CDS argR NC_009004.1 2266696 2267154 D PF01316: Arginine repressor, PF02863: Arginine repressor, C-terminal domain, TIGR01529: arginine repressor; High confidence in function and specificity; arginine repressor ArgR 2266696..2267154 Lactococcus lactis subsp. cremoris MG1363 4799140 YP_001033561.1 CDS murC NC_009004.1 2267316 2268647 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(2267316..2268647) Lactococcus lactis subsp. cremoris MG1363 4799142 YP_001033562.1 CDS llmg_2318 NC_009004.1 2268848 2269447 R hypothetical protein complement(2268848..2269447) Lactococcus lactis subsp. cremoris MG1363 4797414 YP_001033563.1 CDS snf NC_009004.1 2269664 2272768 R PF00176:SNF2 family N-terminal domain; Family membership; SWI/SNF family helicase complement(2269664..2272768) Lactococcus lactis subsp. cremoris MG1363 4798076 YP_001033564.1 CDS llmg_2320 NC_009004.1 2272997 2277331 R hypothetical protein complement(2272997..2277331) Lactococcus lactis subsp. cremoris MG1363 4798445 YP_001033565.1 CDS poxL NC_009004.1 2277746 2279473 R PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity; pyruvate oxidase complement(2277746..2279473) Lactococcus lactis subsp. cremoris MG1363 4798181 YP_001033566.1 CDS llmg_2322 NC_009004.1 2279723 2280679 R PF00144: Beta-lactamase; hypothetical protein complement(2279723..2280679) Lactococcus lactis subsp. cremoris MG1363 4797143 YP_001033567.1 CDS llmg_2323 NC_009004.1 2280752 2281531 R Conserved hypothetical protein; hypothetical protein complement(2280752..2281531) Lactococcus lactis subsp. cremoris MG1363 4798220 YP_001033568.1 CDS llmg_2324 NC_009004.1 2281993 2282325 R hypothetical protein complement(2281993..2282325) Lactococcus lactis subsp. cremoris MG1363 4798218 YP_001033569.1 CDS llmg_2325 NC_009004.1 2282357 2282863 R IPR009002: FMN-binding split barrel; hypothetical protein complement(2282357..2282863) Lactococcus lactis subsp. cremoris MG1363 4797049 YP_001033570.1 CDS llmg_2326 NC_009004.1 2283229 2284011 D PF02517: CAAX amino terminal protease , Abortive infection protein; Conserved hypothetical protein; hypothetical protein 2283229..2284011 Lactococcus lactis subsp. cremoris MG1363 4797134 YP_001033571.1 CDS glpF3 NC_009004.1 2284047 2284916 R PF00230: Major intrinsic protein, TIGR00861: MIP family channel proteins; Family membership; glycerol uptake facilitator protein complement(2284047..2284916) Lactococcus lactis subsp. cremoris MG1363 4798088 YP_001033572.1 CDS pepXP NC_009004.1 2285088 2287379 D catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 2285088..2287379 Lactococcus lactis subsp. cremoris MG1363 4798350 YP_001033573.1 CDS llmg_2329 NC_009004.1 2287381 2288091 D PF07722: Peptidase C26; hypothetical protein 2287381..2288091 Lactococcus lactis subsp. cremoris MG1363 4798728 YP_001033574.1 CDS llmg_2330 NC_009004.1 2288241 2289083 D PF00497: Bacterial extracellular solute-binding protein, family 3; Family membership; amino-acid ABC transporter extracellular binding protein 2288241..2289083 Lactococcus lactis subsp. cremoris MG1363 4796941 YP_001033575.1 CDS llmg_2331 NC_009004.1 2289174 2290496 R PF00070: Pyridine nucleotide-disulphide oxidoreductase, TIGR02053: mercuric reductase; High confidence in function and specificity; pyridine nucleotide-disulfide oxidoreductase complement(2289174..2290496) Lactococcus lactis subsp. cremoris MG1363 4798296 YP_001033576.1 CDS gltX NC_009004.1 2290608 2292059 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2290608..2292059) Lactococcus lactis subsp. cremoris MG1363 4798062 YP_001033577.1 CDS llmg_2333 NC_009004.1 2292686 2293228 R PF00857: Isochorismatase hydrolase, Hypothetical isochorismatase; Family membership; hypothetical protein complement(2292686..2293228) Lactococcus lactis subsp. cremoris MG1363 4798637 YP_001033578.1 CDS llmg_2334 NC_009004.1 2293373 2294224 D PF00126: Bacterial regulatory helix-turn-helix protein, lysR family; Conserved hypothetical protein; ORF3; hypothetical protein 2293373..2294224 Lactococcus lactis subsp. cremoris MG1363 4798949 YP_001033579.1 CDS llmg_2335 NC_009004.1 2294257 2295180 R PF01569: PAP2 superfamily, membrane- associated phospholipid phosphatase; Conserved hypothetical protein; hypothetical protein complement(2294257..2295180) Lactococcus lactis subsp. cremoris MG1363 4798952 YP_001033580.1 CDS llmg_2336 NC_009004.1 2295320 2295871 D PF00583: Acetyltransferase (GNAT) family; Conserved hypothetical protein; acetyltransferase 2295320..2295871 Lactococcus lactis subsp. cremoris MG1363 4798955 YP_001033581.1 CDS llmg_2337 NC_009004.1 2295962 2296285 R PF06304: Protein of unknown function (DUF1048); hypothetical protein complement(2295962..2296285) Lactococcus lactis subsp. cremoris MG1363 4798956 YP_001033582.1 CDS llmg_2338 NC_009004.1 2296282 2296620 R PF06304: Protein of unknown function (DUF1048); hypothetical protein complement(2296282..2296620) Lactococcus lactis subsp. cremoris MG1363 4797341 YP_001033583.1 CDS llmg_2339 NC_009004.1 2296613 2296969 R PF03551: Transcriptional regulator PadR-like family; Family membership; transcriptional regulator complement(2296613..2296969) Lactococcus lactis subsp. cremoris MG1363 4797325 YP_001033584.1 CDS llmg_2340 NC_009004.1 2297090 2297719 R IPR009002: FMN-binding split barrel; hypothetical protein complement(2297090..2297719) Lactococcus lactis subsp. cremoris MG1363 4797350 YP_001033585.1 CDS llmg_2341 NC_009004.1 2297778 2298863 R hypothetical protein complement(2297778..2298863) Lactococcus lactis subsp. cremoris MG1363 4797305 YP_001033586.1 CDS llmg_2342 NC_009004.1 2299130 2299807 D PF06912: Protein of unknown function DUF1275; Conserved hypothetical protein; hypothetical protein 2299130..2299807 Lactococcus lactis subsp. cremoris MG1363 4797939 YP_001033587.1 CDS radA NC_009004.1 2299853 2301214 R Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA complement(2299853..2301214) Lactococcus lactis subsp. cremoris MG1363 4797910 YP_001033588.1 CDS llmg_2344 NC_009004.1 2301833 2302396 R PF00535: Glycosyl transferase, family 2; Family membership; glycosyl transferase family protein complement(2301833..2302396) Lactococcus lactis subsp. cremoris MG1363 4798009 YP_001033589.1 CDS llmg_2345 NC_009004.1 2302378 2302923 R TIGR01656 : histidinol-phosphate phosphatase domain, hisB like protein; High confidence in function and specificity; histidinol-phosphate phosphatase complement(2302378..2302923) Lactococcus lactis subsp. cremoris MG1363 4797956 YP_001033590.1 CDS gmhA NC_009004.1 2302920 2303495 R PF01380: Sugar isomerase (SIS domain), TIGR00441: phosphoheptose isomerase; High confidence in function and specificity; GmhA protein complement(2302920..2303495) Lactococcus lactis subsp. cremoris MG1363 4797273 YP_001033591.1 CDS llmg_2347 NC_009004.1 2303557 2304531 R PF00288: GHMP kinases ATP-binding protein; Family membership; hypothetical protein complement(2303557..2304531) Lactococcus lactis subsp. cremoris MG1363 4798756 YP_001033592.1 CDS llmg_2348 NC_009004.1 2304561 2306084 R Conserved hypothetical protein; hypothetical protein complement(2304561..2306084) Lactococcus lactis subsp. cremoris MG1363 4797314 YP_001033593.1 CDS llmg_2349 NC_009004.1 2306158 2307081 R PF01531: Glycosyl transferase, family 11; Family membership; glycosyl transferase family protein complement(2306158..2307081) Lactococcus lactis subsp. cremoris MG1363 4797250 YP_001033594.1 CDS llmg_2350 NC_009004.1 2307078 2308037 R PF00535: Glycosyl transferase, family 2; Family membership; glycosyl transferase family protein complement(2307078..2308037) Lactococcus lactis subsp. cremoris MG1363 4798646 YP_001033595.1 CDS llmg_2351 NC_009004.1 2308056 2309036 R PF00535: Glycosyl transferase, family 2; Family membership; glycosyl transferase family protein complement(2308056..2309036) Lactococcus lactis subsp. cremoris MG1363 4799024 YP_001033596.1 CDS murM NC_009004.1 2309043 2310233 R PF02388: FemAB family, considered as a factor influencing the level of methicillin resistance in Staphylococcus aureus; Conserved hypothetical protein; peptidoglycan branched peptide synthesis protein complement(2309043..2310233) Lactococcus lactis subsp. cremoris MG1363 4798516 YP_001033597.1 CDS rplQ NC_009004.1 2310945 2311325 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(2310945..2311325) Lactococcus lactis subsp. cremoris MG1363 4797004 YP_001033598.1 CDS rpoA NC_009004.1 2311344 2312282 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(2311344..2312282) Lactococcus lactis subsp. cremoris MG1363 4797865 YP_001033599.1 CDS rpsK NC_009004.1 2312331 2312714 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(2312331..2312714) Lactococcus lactis subsp. cremoris MG1363 4798819 YP_001033600.1 CDS rpsM NC_009004.1 2312735 2313100 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(2312735..2313100) Lactococcus lactis subsp. cremoris MG1363 4798259 YP_001033601.1 CDS rpmJ NC_009004.1 2313118 2313234 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(2313118..2313234) Lactococcus lactis subsp. cremoris MG1363 4797226 YP_001033602.1 CDS infA NC_009004.1 2313288 2313506 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(2313288..2313506) Lactococcus lactis subsp. cremoris MG1363 4798815 YP_001033603.1 CDS adk NC_009004.1 2313809 2314456 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(2313809..2314456) Lactococcus lactis subsp. cremoris MG1363 4797666 YP_001033604.1 CDS secY NC_009004.1 2314596 2315915 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(2314596..2315915) Lactococcus lactis subsp. cremoris MG1363 4797668 YP_001033605.1 CDS rplO NC_009004.1 2315993 2316436 R late assembly protein; 50S ribosomal protein L15 complement(2315993..2316436) Lactococcus lactis subsp. cremoris MG1363 4797213 YP_001033606.1 CDS rpmD NC_009004.1 2316732 2316911 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(2316732..2316911) Lactococcus lactis subsp. cremoris MG1363 4797873 YP_001033607.1 CDS rpsE NC_009004.1 2316922 2317428 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(2316922..2317428) Lactococcus lactis subsp. cremoris MG1363 4798090 YP_001033608.1 CDS rplR NC_009004.1 2317447 2317794 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(2317447..2317794) Lactococcus lactis subsp. cremoris MG1363 4799022 YP_001033609.1 CDS rplF NC_009004.1 2318063 2318599 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(2318063..2318599) Lactococcus lactis subsp. cremoris MG1363 4797863 YP_001033610.1 CDS rpsH NC_009004.1 2318816 2319214 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(2318816..2319214) Lactococcus lactis subsp. cremoris MG1363 4797933 YP_001033611.1 CDS llmg_2368 NC_009004.1 2319420 2319680 R hypothetical protein complement(2319420..2319680) Lactococcus lactis subsp. cremoris MG1363 4798934 YP_001033612.1 CDS llmg_2369 NC_009004.1 2319744 2320025 R hypothetical protein complement(2319744..2320025) Lactococcus lactis subsp. cremoris MG1363 4798005 YP_001033613.1 CDS rpsN NC_009004.1 2320176 2320361 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 complement(2320176..2320361) Lactococcus lactis subsp. cremoris MG1363 4798055 YP_001033614.1 CDS rplE NC_009004.1 2320380 2320922 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(2320380..2320922) Lactococcus lactis subsp. cremoris MG1363 4797215 YP_001033615.1 CDS rplX NC_009004.1 2320942 2321247 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(2320942..2321247) Lactococcus lactis subsp. cremoris MG1363 4797891 YP_001033616.1 CDS rplN NC_009004.1 2321381 2321749 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(2321381..2321749) Lactococcus lactis subsp. cremoris MG1363 4799034 YP_001033617.1 CDS rpsQ NC_009004.1 2321772 2322032 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(2321772..2322032) Lactococcus lactis subsp. cremoris MG1363 4798014 YP_001033618.1 CDS rpmC NC_009004.1 2322053 2322262 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(2322053..2322262) Lactococcus lactis subsp. cremoris MG1363 4797789 YP_001033619.1 CDS rplP NC_009004.1 2322262 2322675 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(2322262..2322675) Lactococcus lactis subsp. cremoris MG1363 4798472 YP_001033620.1 CDS rpsC NC_009004.1 2322679 2323332 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(2322679..2323332) Lactococcus lactis subsp. cremoris MG1363 4797871 YP_001033621.1 CDS rplV NC_009004.1 2323345 2323692 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(2323345..2323692) Lactococcus lactis subsp. cremoris MG1363 4798792 YP_001033622.1 CDS rpsS NC_009004.1 2323708 2323986 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(2323708..2323986) Lactococcus lactis subsp. cremoris MG1363 4797839 YP_001033623.1 CDS rplB NC_009004.1 2324146 2324976 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(2324146..2324976) Lactococcus lactis subsp. cremoris MG1363 4798645 YP_001033624.1 CDS rplW NC_009004.1 2324992 2325285 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(2324992..2325285) Lactococcus lactis subsp. cremoris MG1363 4798431 YP_001033625.1 CDS rplD NC_009004.1 2325285 2325911 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(2325285..2325911) Lactococcus lactis subsp. cremoris MG1363 4798524 YP_001033626.1 CDS rplC NC_009004.1 2325937 2326560 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(2325937..2326560) Lactococcus lactis subsp. cremoris MG1363 4798418 YP_001033627.1 CDS rpsJ NC_009004.1 2326579 2326887 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(2326579..2326887) Lactococcus lactis subsp. cremoris MG1363 4798419 YP_001033628.1 CDS mscL NC_009004.1 2327222 2327587 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 2327222..2327587 Lactococcus lactis subsp. cremoris MG1363 4798275 YP_001033629.1 CDS llmg_2386 NC_009004.1 2327625 2328914 R multidrug resistance protein, PF01554: MatE, TIGR00797MATE efflux family protein; hypothetical protein complement(2327625..2328914) Lactococcus lactis subsp. cremoris MG1363 4796805 YP_001033630.1 CDS thrC NC_009004.1 2328911 2330401 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(2328911..2330401) Lactococcus lactis subsp. cremoris MG1363 4798502 YP_001033631.1 CDS nusG NC_009004.1 2330500 2331057 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(2330500..2331057) Lactococcus lactis subsp. cremoris MG1363 4796940 YP_001033632.1 CDS secE NC_009004.1 2331263 2331457 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(2331263..2331457) Lactococcus lactis subsp. cremoris MG1363 4798605 YP_001033633.1 CDS rpmG NC_009004.1 2331569 2331718 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(2331569..2331718) Lactococcus lactis subsp. cremoris MG1363 4797237 YP_001033634.1 CDS llmg_2391 NC_009004.1 2331759 2333576 R acyltransferase, PF01757: Acyltransferase; Conserved hypothetical protein; hypothetical protein complement(2331759..2333576) Lactococcus lactis subsp. cremoris MG1363 4798801 YP_001033635.1 CDS pbp2A NC_009004.1 2333678 2335909 R PF00912: Transglycosylase; High confidence in function and specificity; penicillin-binding protein 2a complement(2333678..2335909) Lactococcus lactis subsp. cremoris MG1363 4798109 YP_001033636.1 CDS llmg_2393 NC_009004.1 2336296 2336931 R PF04239: Protein of unknown function DUF421; hypothetical protein complement(2336296..2336931) Lactococcus lactis subsp. cremoris MG1363 4798553 YP_001033637.1 CDS llmg_2394 NC_009004.1 2336949 2337380 R hypothetical protein complement(2336949..2337380) Lactococcus lactis subsp. cremoris MG1363 4798081 YP_001033638.1 CDS llmg_2395 NC_009004.1 2337495 2337911 R FMN-binding protein, IPR009002: FMN- binding split barrel; hypothetical protein complement(2337495..2337911) Lactococcus lactis subsp. cremoris MG1363 4796847 YP_001033639.1 CDS rluA NC_009004.1 2338067 2338939 D PF00849: RNA pseudouridylate synthase , TIGR00005: ribosomal large subunit pseudouridine synthases, RluD subfamily; High confidence in function and specificity; ribosomal large subunit pseudouridine synthase 2338067..2338939 Lactococcus lactis subsp. cremoris MG1363 4796857 YP_001033640.1 CDS zitP NC_009004.1 2340471 2341280 R PF00950: ABC-3 transport family; High confidence in function and specificity; zinc ABC transporter permease complement(2340471..2341280) Lactococcus lactis subsp. cremoris MG1363 4799038 YP_001033641.1 CDS zitQ NC_009004.1 2341273 2342010 R PF00005: ABC transporter; High confidence in function and specificity; zinc ABC transporter ATP binding protein complement(2341273..2342010) Lactococcus lactis subsp. cremoris MG1363 4797161 YP_001033642.1 CDS zitS NC_009004.1 2342189 2343031 R PF01297.7: Periplasmic solute binding protein family; High confidence in function and specificity; zinc ABC transporter substrate binding protein complement(2342189..2343031) Lactococcus lactis subsp. cremoris MG1363 4797162 YP_001033643.1 CDS zitR NC_009004.1 2343028 2343465 R PF01047.9: Bacterial regulatory protein, MarR; High confidence in function and specificity; transcriptional regulator of the zit operon complement(2343028..2343465) Lactococcus lactis subsp. cremoris MG1363 4799067 YP_001033644.1 CDS llmg_2402 NC_009004.1 2343546 2343845 R hypothetical protein complement(2343546..2343845) Lactococcus lactis subsp. cremoris MG1363 4798053 YP_001033645.1 CDS llmg_2403 NC_009004.1 2343869 2344315 R hypothetical protein complement(2343869..2344315) Lactococcus lactis subsp. cremoris MG1363 4797498 YP_001033646.1 CDS llmg_2404 NC_009004.1 2344278 2344664 R hypothetical protein complement(2344278..2344664) Lactococcus lactis subsp. cremoris MG1363 4797503 YP_001033647.1 CDS comGD NC_009004.1 2344546 2344989 R High confidence in function and specificity; competence protein ComGD complement(2344546..2344989) Lactococcus lactis subsp. cremoris MG1363 4797507 YP_001033648.1 CDS comGC NC_009004.1 2344937 2345314 R Specificity unclear; competence protein ComGC complement(2344937..2345314) Lactococcus lactis subsp. cremoris MG1363 4798798 YP_001033649.1 CDS comGB NC_009004.1 2345332 2346420 R PF00482: Bacterial type II secretion system protein F domain, membrane protein; Conserved hypothetical protein; competence protein ComGB complement(2345332..2346420) Lactococcus lactis subsp. cremoris MG1363 4798796 YP_001033650.1 CDS comGA NC_009004.1 2346257 2347237 R PF00437: Type II/IV secretion system protein; Conserved hypothetical protein; competence protein ComGA complement(2346257..2347237) Lactococcus lactis subsp. cremoris MG1363 4798794 YP_001033651.1 CDS polC NC_009004.1 2347351 2352258 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC complement(2347351..2352258) Lactococcus lactis subsp. cremoris MG1363 4798790 YP_001033652.1 CDS llmg_2410 NC_009004.1 2352432 2352968 R hypothetical protein complement(2352432..2352968) Lactococcus lactis subsp. cremoris MG1363 4797074 YP_001033653.1 CDS proS NC_009004.1 2354322 2356172 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(2354322..2356172) Lactococcus lactis subsp. cremoris MG1363 4796999 YP_001033654.1 CDS llmg_2413 NC_009004.1 2356242 2357528 R PF02163: Peptidase M50, TIGR00054: membrane- associated zinc metalloprotease, High confidence in function and specificity; zinc metalloprotease complement(2356242..2357528) Lactococcus lactis subsp. cremoris MG1363 4797040 YP_001033655.1 CDS cdsA NC_009004.1 2357547 2358350 R PF01148.9: Phosphatidate cytidylyltransferase, PF01148: Cytidylyltransferase; High confidence in function and specificity; phosphatidate cytidylyltransferase complement(2357547..2358350) Lactococcus lactis subsp. cremoris MG1363 4797516 YP_001033656.1 CDS uppS NC_009004.1 2358350 2359084 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase complement(2358350..2359084) Lactococcus lactis subsp. cremoris MG1363 4798290 YP_001033657.1 CDS yajC NC_009004.1 2359435 2359767 R PF02699: Preprotein translocase subunit, TIGR00739: preprotein translocase, YajC subunit; hypothetical protein complement(2359435..2359767) Lactococcus lactis subsp. cremoris MG1363 4797262 YP_001033658.1 CDS llmg_2417 NC_009004.1 2359862 2360560 R hypothetical protein complement(2359862..2360560) Lactococcus lactis subsp. cremoris MG1363 4798925 YP_001033659.1 CDS llmg_2418 NC_009004.1 2360578 2361057 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2360578..2361057) Lactococcus lactis subsp. cremoris MG1363 4798521 YP_001033660.1 CDS htrA NC_009004.1 2361433 2362656 D serine protease, PF00089: Trypsin, TIGR02037: degP_htrA_DO (protease DO); High confidence in function and specificity; housekeeping protease 2361433..2362656 Lactococcus lactis subsp. cremoris MG1363 4797497 YP_001033661.1 CDS llmg_2420 NC_009004.1 2362776 2363774 D PF00534: Glycosyl transferasegroup 1; hypothetical protein 2362776..2363774 Lactococcus lactis subsp. cremoris MG1363 4797677 YP_001033662.1 CDS llmg_2421 NC_009004.1 2363920 2365260 D PF00534: Glycosyl transferases group 1; hypothetical protein 2363920..2365260 Lactococcus lactis subsp. cremoris MG1363 4797505 YP_001033663.1 CDS llmg_2422 NC_009004.1 2365368 2365592 D hypothetical protein 2365368..2365592 Lactococcus lactis subsp. cremoris MG1363 4797519 YP_001033664.1 CDS llmg_2423 NC_009004.1 2365736 2366740 D hypothetical protein 2365736..2366740 Lactococcus lactis subsp. cremoris MG1363 4797921 YP_001033665.1 CDS llmg_2424 NC_009004.1 2366797 2367549 R PF01367: SAM (and some other nucleotide) binding motif; hypothetical protein complement(2366797..2367549) Lactococcus lactis subsp. cremoris MG1363 4798941 YP_001033666.1 CDS polA NC_009004.1 2367757 2370390 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(2367757..2370390) Lactococcus lactis subsp. cremoris MG1363 4797780 YP_001033667.1 CDS llmg_2426 NC_009004.1 2370652 2371407 D TIGR00099: Cof-like hydrolase; hypothetical protein 2370652..2371407 Lactococcus lactis subsp. cremoris MG1363 4799048 YP_001033668.1 CDS comX NC_009004.1 2376782 2377273 R Sigma factor, regulation of competence; competence regulator ComX complement(2376782..2377273) Lactococcus lactis subsp. cremoris MG1363 4797447 YP_001033669.1 CDS ezrA NC_009004.1 2377538 2379268 R acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA complement(2377538..2379268) Lactococcus lactis subsp. cremoris MG1363 4798799 YP_001033670.1 CDS tsf NC_009004.1 2379473 2380501 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2379473..2380501) Lactococcus lactis subsp. cremoris MG1363 4797460 YP_001033671.1 CDS rpsB NC_009004.1 2380623 2381390 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2380623..2381390) Lactococcus lactis subsp. cremoris MG1363 4797347 YP_001033672.1 CDS llmg_2431 NC_009004.1 2381785 2382810 D hypothetical protein 2381785..2382810 Lactococcus lactis subsp. cremoris MG1363 4798780 YP_001033673.1 CDS adhE NC_009004.1 2383065 2385776 D PF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 2383065..2385776 Lactococcus lactis subsp. cremoris MG1363 4798121 YP_001033674.1 CDS llmg_2433 NC_009004.1 2386051 2386158 R hypothetical protein complement(2386051..2386158) Lactococcus lactis subsp. cremoris MG1363 4797633 YP_001033675.1 CDS llmg_2434 NC_009004.1 2386240 2386737 R hypothetical protein complement(2386240..2386737) Lactococcus lactis subsp. cremoris MG1363 4797520 YP_001033676.1 CDS llmg_2435 NC_009004.1 2386724 2386933 R Region start changed from 2386948 to 2386933 (-15 bases); hypothetical protein complement(2386724..2386933) Lactococcus lactis subsp. cremoris MG1363 4798541 YP_001033677.1 CDS llmg_2436 NC_009004.1 2386930 2387757 R PF04055: Radical SAM superfamily; Family membership; hypothetical protein complement(2386930..2387757) Lactococcus lactis subsp. cremoris MG1363 4798763 YP_001033678.1 CDS llmg_2438 NC_009004.1 2389975 2390832 R TIGR01716: Transcriptional activator Rgg/GadR/MutR, C-terminal domain, IPR010057: Transcriptional activator Rgg/GadR/MutR, C-terminal; Conserved hypothetical protein; HTH-type transcriptional regulator complement(2389975..2390832) Lactococcus lactis subsp. cremoris MG1363 4796770 YP_001033679.1 CDS llmg_2439 NC_009004.1 2390884 2392020 R PF07690: Major facilitator superfamily MFS_1; hypothetical protein complement(2390884..2392020) Lactococcus lactis subsp. cremoris MG1363 4798327 YP_001033680.1 CDS llmg_2440 NC_009004.1 2392017 2393336 R Coenzyme PQQ synthesis protein E , PF04055: Radical SAM superfamily, IPR006638 Elongator protein 3/MiaB/NifB; High confidence in function and specificity; hypothetical protein complement(2392017..2393336) Lactococcus lactis subsp. cremoris MG1363 4797435 YP_001033681.1 CDS llmg_2441 NC_009004.1 2393404 2393517 R hypothetical protein complement(2393404..2393517) Lactococcus lactis subsp. cremoris MG1363 4798776 YP_001033682.1 CDS llmg_2442 NC_009004.1 2393837 2394868 R Conserved hypothetical protein; hypothetical protein complement(2393837..2394868) Lactococcus lactis subsp. cremoris MG1363 4797730 YP_001033683.1 CDS coaD NC_009004.1 2394852 2395352 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(2394852..2395352) Lactococcus lactis subsp. cremoris MG1363 4798324 YP_001033684.1 CDS llmg_2444 NC_009004.1 2395400 2395939 R PF03602:Conserved hypothetical protein 95, TIGR00095: methyltransferase; hypothetical protein complement(2395400..2395939) Lactococcus lactis subsp. cremoris MG1363 4796696 YP_001033685.1 CDS llmg_2445 NC_009004.1 2396112 2397329 R PF07690: Major facilitator superfamilyI, TIGR00880: Multidrug resistance protein; Conserved hypothetical protein; multidrug resistance protein complement(2396112..2397329) Lactococcus lactis subsp. cremoris MG1363 4798080 YP_001033686.1 CDS lmrP NC_009004.1 2397414 2398640 R PF07690: Major facilitator superfamily I, TIGR00880: Multidrug resistance protein; High confidence in function and specificity; multidrug resistance protein complement(2397414..2398640) Lactococcus lactis subsp. cremoris MG1363 4797726 YP_001033687.1 CDS llmg_2447 NC_009004.1 2399342 2400448 D hypothetical protein 2399342..2400448 Lactococcus lactis subsp. cremoris MG1363 4798622 YP_001033688.1 CDS pgi NC_009004.1 2400544 2401890 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(2400544..2401890) Lactococcus lactis subsp. cremoris MG1363 4797611 YP_001033689.1 CDS llmg_2449 NC_009004.1 2402210 2402740 D PF03692.4: Protein of unknown function UPF0153; hypothetical protein 2402210..2402740 Lactococcus lactis subsp. cremoris MG1363 4798372 YP_001033690.1 CDS llmg_2450 NC_009004.1 2402774 2403514 R alcohol dehydrogenase; hypothetical protein complement(2402774..2403514) Lactococcus lactis subsp. cremoris MG1363 4797615 YP_001033691.1 CDS llmg_2451 NC_009004.1 2403560 2404363 R transcriptional regulator, IPR010982: Lambda repressor-like, DNA-binding; hypothetical protein complement(2403560..2404363) Lactococcus lactis subsp. cremoris MG1363 4797624 YP_001033692.1 CDS llmg_2452 NC_009004.1 2404433 2405278 R hypothetical protein complement(2404433..2405278) Lactococcus lactis subsp. cremoris MG1363 4797628 YP_001033693.1 CDS llmg_2453 NC_009004.1 2405452 2405784 D PF01638: Protein of unknown function DUF24, predicted transcriptional regulator; Conserved hypothetical protein; transcriptional regulator 2405452..2405784 Lactococcus lactis subsp. cremoris MG1363 4797635 YP_001033694.1 CDS llmg_2454 NC_009004.1 2405901 2406230 D hypothetical protein 2405901..2406230 Lactococcus lactis subsp. cremoris MG1363 4797644 YP_001033695.1 CDS valS NC_009004.1 2406273 2408915 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(2406273..2408915) Lactococcus lactis subsp. cremoris MG1363 4797649 YP_001033696.1 CDS llmg_2456 NC_009004.1 2408951 2409439 R hypothetical protein complement(2408951..2409439) Lactococcus lactis subsp. cremoris MG1363 4798436 YP_001033697.1 CDS llmg_2457 NC_009004.1 2409436 2409555 R hypothetical protein complement(2409436..2409555) Lactococcus lactis subsp. cremoris MG1363 4797655 YP_001033698.1 CDS llmg_2458 NC_009004.1 2409746 2410402 R PF07299: Fibronectin-binding protein (FBP); fibronectin-binding protein complement(2409746..2410402) Lactococcus lactis subsp. cremoris MG1363 4797661 YP_001033699.1 CDS llmg_2459 NC_009004.1 2410880 2411128 R hypothetical protein complement(2410880..2411128) Lactococcus lactis subsp. cremoris MG1363 4797667 YP_001033700.1 CDS llmg_2460 NC_009004.1 2411201 2411545 R PF02575: Protein of unknown function DUF419; hypothetical protein complement(2411201..2411545) Lactococcus lactis subsp. cremoris MG1363 4797672 YP_001033701.1 CDS llmg_2461 NC_009004.1 2411538 2412059 R hypothetical protein complement(2411538..2412059) Lactococcus lactis subsp. cremoris MG1363 4797679 YP_001033702.1 CDS llmg_2463 NC_009004.1 2412260 2412979 R PF03483: B3/4 domain; hypothetical protein complement(2412260..2412979) Lactococcus lactis subsp. cremoris MG1363 4797684 YP_001033703.1 CDS llmg_2464 NC_009004.1 2413060 2414601 R PF01938: TRAM domain, TIGR00479: 23S rRNA (uracil-5- )-methyltransferase RumA; Conserved hypothetical protein; RNA methyltransferase complement(2413060..2414601) Lactococcus lactis subsp. cremoris MG1363 4797691 YP_001033704.1 CDS llmg_2465 NC_009004.1 2414829 2417606 R PF06458: MucBP domain; hypothetical protein complement(2414829..2417606) Lactococcus lactis subsp. cremoris MG1363 4797701 YP_001033705.1 CDS recX NC_009004.1 2417964 2418773 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2417964..2418773 Lactococcus lactis subsp. cremoris MG1363 4797707 YP_001033706.1 CDS gntP NC_009004.1 2424123 2425538 R PF02447: GntP family permease, TIGR00791: gluconate transporter; High confidence in function and specificity; gluconate transport protein complement(2424123..2425538) Lactococcus lactis subsp. cremoris MG1363 4798480 YP_001033707.1 CDS gntK NC_009004.1 2425675 2427183 R PF00370: FGGY family of carbohydrate kinases, N- terminal domain, TIGR01314: gntK_FGGY: gluconate kinase; High confidence in function and specificity; gluconate kinase complement(2425675..2427183) Lactococcus lactis subsp. cremoris MG1363 4798483 YP_001033708.1 CDS gntZ NC_009004.1 2427450 2428355 R similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase complement(2427450..2428355) Lactococcus lactis subsp. cremoris MG1363 4797450 YP_001033709.1 CDS gntR NC_009004.1 2428725 2429573 D PF01418: Helix-turn-helix domain, RpiR family , PF01380: SIS domain sugar isomerase domain; Conserved hypothetical protein; RpiR family transcriptional regulator 2428725..2429573 Lactococcus lactis subsp. cremoris MG1363 4798587 YP_001033710.1 CDS llmg_2471 NC_009004.1 2429612 2429920 D hypothetical protein 2429612..2429920 Lactococcus lactis subsp. cremoris MG1363 4798210 YP_001033711.1 CDS llmg_2472 NC_009004.1 2429992 2430777 R IPR004843: Metallophosphoesterase; hypothetical protein complement(2429992..2430777) Lactococcus lactis subsp. cremoris MG1363 4797711 YP_001033712.1 CDS rpsR NC_009004.1 2430908 2431153 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(2430908..2431153) Lactococcus lactis subsp. cremoris MG1363 4796709 YP_001033713.1 CDS ssbB NC_009004.1 2431325 2431825 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(2431325..2431825) Lactococcus lactis subsp. cremoris MG1363 4797809 YP_001033714.1 CDS rpsF NC_009004.1 2431855 2432148 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(2431855..2432148) Lactococcus lactis subsp. cremoris MG1363 4798594 YP_001033715.1 CDS bacA NC_009004.1 2432342 2433196 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(2432342..2433196) Lactococcus lactis subsp. cremoris MG1363 4799148 YP_001033716.1 CDS llmg_2477 NC_009004.1 2433658 2435184 D Region start changed from 2433717 to 2433657 (60 bases); lysine specific permease 2433658..2435184 Lactococcus lactis subsp. cremoris MG1363 4798635 YP_001033717.1 CDS dnaX NC_009004.1 2435218 2436879 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(2435218..2436879) Lactococcus lactis subsp. cremoris MG1363 4796796 YP_001033718.1 CDS llmg_2479 NC_009004.1 2436925 2437566 R IPR011009: Protein kinase-like; hypothetical protein complement(2436925..2437566) Lactococcus lactis subsp. cremoris MG1363 4798402 YP_001033719.1 CDS llmg_2480 NC_009004.1 2437598 2438086 R GAF; hypothetical protein complement(2437598..2438086) Lactococcus lactis subsp. cremoris MG1363 4796623 YP_001033720.1 CDS llmg_2481 NC_009004.1 2438170 2438442 D PF01817: Chorismate mutase type II, TIGR01805: CM_mono_grmpos: chorismate mutase; Family membership; hypothetical protein 2438170..2438442 Lactococcus lactis subsp. cremoris MG1363 4796617 YP_001033721.1 CDS llmg_2482 NC_009004.1 2438477 2438926 R hypothetical protein complement(2438477..2438926) Lactococcus lactis subsp. cremoris MG1363 4796586 YP_001033722.1 CDS llmg_2483 NC_009004.1 2439144 2439344 D hypothetical protein 2439144..2439344 Lactococcus lactis subsp. cremoris MG1363 4797469 YP_001033723.1 CDS glnA NC_009004.1 2439405 2440745 R PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity; GlnA protein complement(2439405..2440745) Lactococcus lactis subsp. cremoris MG1363 4797464 YP_001033724.1 CDS glnR NC_009004.1 2440807 2441172 R GLNR, MerR family transcriptional regulator; High confidence in function and specificity; glutamine synthetase complement(2440807..2441172) Lactococcus lactis subsp. cremoris MG1363 4797312 YP_001033725.1 CDS ptpL NC_009004.1 2441273 2441710 R PF01451: Low molecular weight phosphotyrosine protein phosphatase; High confidence in function and specificity; protein-tyrosine-phosphatase complement(2441273..2441710) Lactococcus lactis subsp. cremoris MG1363 4796835 YP_001033726.1 CDS ruvB NC_009004.1 2441855 2442856 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2441855..2442856) Lactococcus lactis subsp. cremoris MG1363 4797675 YP_001033727.1 CDS ruvA NC_009004.1 2443004 2443597 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2443004..2443597) Lactococcus lactis subsp. cremoris MG1363 4797168 YP_001033728.1 CDS mutL NC_009004.1 2443649 2445619 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(2443649..2445619) Lactococcus lactis subsp. cremoris MG1363 4797473 YP_001033729.1 CDS llmg_2490 NC_009004.1 2445749 2446444 R hypothetical protein complement(2445749..2446444) Lactococcus lactis subsp. cremoris MG1363 4798617 YP_001033730.1 CDS mutS NC_009004.1 2446554 2449076 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(2446554..2449076) Lactococcus lactis subsp. cremoris MG1363 4797478 YP_001033731.1 CDS llmg_2492 NC_009004.1 2449192 2449539 R hypothetical protein complement(2449192..2449539) Lactococcus lactis subsp. cremoris MG1363 4798536 YP_001033732.1 CDS tnp905 NC_009004.1 2449740 2450915 D PF00872: Transposase, Mutator family; Conserved hypothetical protein; transposase for insertion sequence element IS905N 2449740..2450915 Lactococcus lactis subsp. cremoris MG1363 4798655 YP_001033733.1 CDS ywjF NC_009004.1 2451026 2451907 R TIGR01505: 2-hydroxy-3-oxopropionate reductase; Conserved hypothetical protein; 3-hydroxyisobutyrate dehydrogenase complement(2451026..2451907) Lactococcus lactis subsp. cremoris MG1363 4797816 YP_001033734.1 CDS llmg_2495 NC_009004.1 2451950 2452270 R Region start changed from 2452228 to 2452270 (42 bases); hypothetical protein complement(2451950..2452270) Lactococcus lactis subsp. cremoris MG1363 4797436 YP_001033735.1 CDS llmg_2496 NC_009004.1 2452387 2452764 R PF07843: Protein of unknown function (DUF1634); hypothetical protein complement(2452387..2452764) Lactococcus lactis subsp. cremoris MG1363 4796906 YP_001033736.1 CDS llmg_2497 NC_009004.1 2452764 2453615 R PF01925: Protein of unknown function DUF81; hypothetical protein complement(2452764..2453615) Lactococcus lactis subsp. cremoris MG1363 4797561 YP_001033737.1 CDS llmg_2498 NC_009004.1 2453799 2453978 D hypothetical protein 2453799..2453978 Lactococcus lactis subsp. cremoris MG1363 4796734 YP_001033738.1 CDS llmg_2499 NC_009004.1 2454098 2455609 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2454098..2455609 Lactococcus lactis subsp. cremoris MG1363 4796825 YP_001033739.1 CDS llmg_2500 NC_009004.1 2455805 2456332 R TIGR01668: HAD-superfamily, subfamily IIIA phosphatase; hypothetical protein complement(2455805..2456332) Lactococcus lactis subsp. cremoris MG1363 4798538 YP_001033740.1 CDS dnaJ NC_009004.1 2456461 2457600 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(2456461..2457600) Lactococcus lactis subsp. cremoris MG1363 4796631 YP_001033741.1 CDS racD NC_009004.1 2458449 2459171 R PF01177: Asp/Glu/Hydantoin racemase; High confidence in function and specificity; RacD protein complement(2458449..2459171) Lactococcus lactis subsp. cremoris MG1363 4797808 YP_001033742.1 CDS llmg_2505 NC_009004.1 2459203 2460429 R hypothetical protein complement(2459203..2460429) Lactococcus lactis subsp. cremoris MG1363 4797911 YP_001033743.1 CDS asnH NC_009004.1 2460441 2462318 R Asparagine synthetase (glutamine-hydrolyzing), PF00733: Asparagine synthase; High confidence in function and specificity; asparagine synthase complement(2460441..2462318) Lactococcus lactis subsp. cremoris MG1363 4797108 YP_001033744.1 CDS usp45 NC_009004.1 2462440 2463825 R PF05257: CHAP domain, IPR011050: Pectin lyase- like; Conserved hypothetical protein; secreted 45 kDa protein precursor complement(2462440..2463825) Lactococcus lactis subsp. cremoris MG1363 4797218 YP_001033745.1 CDS llmg_2508 NC_009004.1 2463929 2464456 R Region start changed from 2464405 to 2464456 (51 bases); cell shape determining protein mreD complement(2463929..2464456) Lactococcus lactis subsp. cremoris MG1363 4798305 YP_001033746.1 CDS mreC NC_009004.1 2464535 2465410 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2464535..2465410) Lactococcus lactis subsp. cremoris MG1363 4798257 YP_001033747.1 CDS mutT NC_009004.1 2465701 2466141 D mutator protein 2465701..2466141 Lactococcus lactis subsp. cremoris MG1363 4797526 YP_001033748.1 CDS rpiA NC_009004.1 2466170 2466844 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(2466170..2466844) Lactococcus lactis subsp. cremoris MG1363 4797489 YP_001033749.1 CDS rcfB NC_009004.1 2466928 2467611 R IPR000595: cNMP_binding , CRP/FNR family of transcription regulators; Family membership; transcriptional regulator complement(2466928..2467611) Lactococcus lactis subsp. cremoris MG1363 4797184 YP_001033750.1 CDS llmg_2513 NC_009004.1 2467698 2468918 R Region start changed from 2468930 to 2468918 (-12 bases); transporter complement(2467698..2468918) Lactococcus lactis subsp. cremoris MG1363 4798542 YP_001033751.1 CDS llmg_2514 NC_009004.1 2468981 2469418 R PF00582: Universal stress protein family; hypothetical protein complement(2468981..2469418) Lactococcus lactis subsp. cremoris MG1363 4796687 YP_001033752.1 CDS llmg_2515 NC_009004.1 2469438 2469641 R hypothetical protein complement(2469438..2469641) Lactococcus lactis subsp. cremoris MG1363 4797085 YP_001033753.1 CDS llmg_2516 NC_009004.1 2469872 2474182 R TIGR00241: CoA-substrate-specific enzyme activase, , PF01869: BadF/BadG/BcrA/BcrD ATPase; Family membership; hypothetical protein complement(2469872..2474182) Lactococcus lactis subsp. cremoris MG1363 4798117 YP_001033754.1 CDS llmg_2517 NC_009004.1 2474592 2475206 D Region start changed from 2474583 to 2474592 (-9 bases); hypothetical protein 2474592..2475206 Lactococcus lactis subsp. cremoris MG1363 4797087 YP_001033755.1 CDS llmg_2518 NC_009004.1 2475290 2476276 R Region start changed from 2476018 to 2476276 (258 bases); ribosomal small subunit pseudouridine synthase A complement(2475290..2476276) Lactococcus lactis subsp. cremoris MG1363 4796895 YP_001033756.1 CDS llmg_2520 NC_009004.1 2476285 2476998 R hypothetical protein complement(2476285..2476998) Lactococcus lactis subsp. cremoris MG1363 4796878 YP_001033757.1 CDS trmE NC_009004.1 2477220 2478587 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 2477220..2478587 Lactococcus lactis subsp. cremoris MG1363 4798071 YP_001033758.1 CDS llmg_2522 NC_009004.1 2478636 2479373 R hypothetical protein complement(2478636..2479373) Lactococcus lactis subsp. cremoris MG1363 4799006 YP_001033759.1 CDS recG NC_009004.1 2479373 2481373 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(2479373..2481373) Lactococcus lactis subsp. cremoris MG1363 4798184 YP_001033760.1 CDS phnA NC_009004.1 2481512 2481877 R TIGR00686: Alkylphosphonate utilization operon protein PhnA; Conserved hypothetical protein; alkylphosphonate uptake protein complement(2481512..2481877) Lactococcus lactis subsp. cremoris MG1363 4799117 YP_001033761.1 CDS ps601 NC_009004.1 2481927 2483105 R PF00589: Phage integrase; Conserved hypothetical protein; integrase complement(2481927..2483105) Lactococcus lactis subsp. cremoris MG1363 4796699 YP_001033762.1 CDS ps602 NC_009004.1 2483633 2484235 R IPR010982: Lambda repressor-like, DNA-binding; hypothetical protein complement(2483633..2484235) Lactococcus lactis subsp. cremoris MG1363 4798291 YP_001033763.1 CDS ps603 NC_009004.1 2484619 2485311 D hypothetical protein 2484619..2485311 Lactococcus lactis subsp. cremoris MG1363 4797322 YP_001033764.1 CDS ps604 NC_009004.1 2485565 2486098 D phage associated; hypothetical protein 2485565..2486098 Lactococcus lactis subsp. cremoris MG1363 4797316 YP_001033765.1 CDS ps605 NC_009004.1 2486091 2486372 D IPR009061: DNA binding, phage associated; hypothetical protein 2486091..2486372 Lactococcus lactis subsp. cremoris MG1363 4797302 YP_001033766.1 CDS ps606 NC_009004.1 2486415 2486654 D Phage associated; hypothetical protein 2486415..2486654 Lactococcus lactis subsp. cremoris MG1363 4797295 YP_001033767.1 CDS llmg_2531 NC_009004.1 2486651 2486905 D CDS; hypothetical protein 2486651..2486905 Lactococcus lactis subsp. cremoris MG1363 4797251 YP_001033768.1 CDS ps608 NC_009004.1 2486902 2487231 D hypothetical protein 2486902..2487231 Lactococcus lactis subsp. cremoris MG1363 4798187 YP_001033769.1 CDS ps609 NC_009004.1 2487340 2488134 D hypothetical protein 2487340..2488134 Lactococcus lactis subsp. cremoris MG1363 4797945 YP_001033770.1 CDS ps610 NC_009004.1 2488145 2489773 D Similar to prophage ps105 in L. lactis IL1403, DNA primase, PF03288: Poxvirus D5 protein-like; hypothetical protein 2488145..2489773 Lactococcus lactis subsp. cremoris MG1363 4797938 YP_001033771.1 CDS ps611 NC_009004.1 2490001 2490543 D Similar to prophage ps104 in L. lactis IL1403; hypothetical protein 2490001..2490543 Lactococcus lactis subsp. cremoris MG1363 4797924 YP_001033772.1 CDS ps612 NC_009004.1 2490816 2491118 D hypothetical protein 2490816..2491118 Lactococcus lactis subsp. cremoris MG1363 4797905 YP_001033773.1 CDS ps613 NC_009004.1 2491192 2491602 D Similar to prophage ps102, PF05263: Protein of unknown function DUF722; hypothetical protein 2491192..2491602 Lactococcus lactis subsp. cremoris MG1363 4797900 YP_001033774.1 CDS ps614 NC_009004.1 2491626 2491949 D Similar to ps101 in L. lactis IL1403; hypothetical protein 2491626..2491949 Lactococcus lactis subsp. cremoris MG1363 4797876 YP_001033775.1 CDS gapB NC_009004.1 2492509 2493519 R TIGR01534: Glyceraldehyde-3-phosphate dehydrogenase, type I, PF02800: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; High confidence in function and specificity; glyceraldehyde 3-phosphate dehydrogenase complement(2492509..2493519) Lactococcus lactis subsp. cremoris MG1363 4797877 YP_001033776.1 CDS llmg_2540 NC_009004.1 2493797 2494309 R hypothetical protein complement(2493797..2494309) Lactococcus lactis subsp. cremoris MG1363 4797420 YP_001033777.1 CDS llmg_2541 NC_009004.1 2494447 2497140 D Specificity unclear; cation transporting ATPase 2494447..2497140 Lactococcus lactis subsp. cremoris MG1363 4796973 YP_001033778.1 CDS llmg_2542 NC_009004.1 2497182 2497655 R Region start changed from 2497709 to 2497655 (-54 bases); HTH-type transcriptional regulator complement(2497182..2497655) Lactococcus lactis subsp. cremoris MG1363 4796945 YP_001033779.1 CDS llmg_2543 NC_009004.1 2497834 2498853 D hypothetical protein 2497834..2498853 Lactococcus lactis subsp. cremoris MG1363 4796971 YP_001033780.1 CDS llmg_2544 NC_009004.1 2499079 2499534 D membrane protein; hypothetical protein 2499079..2499534 Lactococcus lactis subsp. cremoris MG1363 4797154 YP_001033781.1 CDS rpsI NC_009004.1 2505530 2505922 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(2505530..2505922) Lactococcus lactis subsp. cremoris MG1363 4798481 YP_001033782.1 CDS rplM NC_009004.1 2505942 2506388 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(2505942..2506388) Lactococcus lactis subsp. cremoris MG1363 4798926 YP_001033783.1 CDS llmg_2547 NC_009004.1 2506786 2507856 D hypothetical protein 2506786..2507856 Lactococcus lactis subsp. cremoris MG1363 4797889 YP_001033784.1 CDS llmg_2548 NC_009004.1 2507872 2508543 D hypothetical protein 2507872..2508543 Lactococcus lactis subsp. cremoris MG1363 4797121 YP_001033785.1 CDS rnhA NC_009004.1 2508690 2509568 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 2508690..2509568 Lactococcus lactis subsp. cremoris MG1363 4798110 YP_001033786.1 CDS sipL NC_009004.1 2509580 2510206 D Signal peptidase I (Leader peptidase I)., TIGR02227: Peptidase S26A, signal peptidase I; High confidence in function and specificity; SipL protein 2509580..2510206 Lactococcus lactis subsp. cremoris MG1363 4797335 YP_001033787.1 CDS purR NC_009004.1 2510254 2511069 R TIGR01743: purR_Bsub, PF00156: Phosphoribosyl transferase domain; High confidence in function and specificity; pur operon repressor complement(2510254..2511069) Lactococcus lactis subsp. cremoris MG1363 4797800 YP_001033788.1 CDS llmg_2552 NC_009004.1 2511357 2511644 R hypothetical protein complement(2511357..2511644) Lactococcus lactis subsp. cremoris MG1363 4797685 YP_001033789.1 CDS llmg_2553 NC_009004.1 2511669 2512325 R membrane protein; hypothetical protein complement(2511669..2512325) Lactococcus lactis subsp. cremoris MG1363 4796929 YP_001033790.1 CDS llmg_2554 NC_009004.1 2512328 2513755 R membrane protein; hypothetical protein complement(2512328..2513755) Lactococcus lactis subsp. cremoris MG1363 4798292 YP_001033791.1 CDS llmg_2555 NC_009004.1 2513755 2514018 R membrane protein; hypothetical protein complement(2513755..2514018) Lactococcus lactis subsp. cremoris MG1363 4797272 YP_001033792.1 CDS fusA NC_009004.1 2514375 2516504 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(2514375..2516504) Lactococcus lactis subsp. cremoris MG1363 4797421 YP_001033793.1 CDS rpsG NC_009004.1 2516765 2517232 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(2516765..2517232) Lactococcus lactis subsp. cremoris MG1363 4797556 YP_001033794.1 CDS rpsL NC_009004.1 2517251 2517664 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(2517251..2517664) Lactococcus lactis subsp. cremoris MG1363 4799037 YP_001033795.1 CDS llmg_2559 NC_009004.1 2518096 2518257 R hypothetical protein complement(2518096..2518257) Lactococcus lactis subsp. cremoris MG1363 4797225 YP_001033796.1 CDS dacA NC_009004.1 2519311 2520615 D D-alanyl-D-alanine carboxypeptidase precursor, PF00768: D-alanyl-D-alanine carboxypeptidase; High confidence in function and specificity; DacA protein 2519311..2520615 Lactococcus lactis subsp. cremoris MG1363 4797426 YP_001033797.1 CDS glcU NC_009004.1 2520690 2521577 R Pf06800: Sugartransport protein, TIGR00776 RhaT: RhaT L-rhamnose-proton symporter family protein; Family membership; glucose uptake protein glcU complement(2520690..2521577) Lactococcus lactis subsp. cremoris MG1363 4798871 YP_001033798.1 CDS llmg_2562 NC_009004.1 2521703 2522338 R Pfam: rRNA methylase; Family membership; hypothetical protein complement(2521703..2522338) Lactococcus lactis subsp. cremoris MG1363 4797047 YP_001033799.1 CDS llmg_2563 NC_009004.1 2522482 2523423 R PF04055: Radical SAM superfamily, TIGR01212 family: radical SAM protein; Family membership; hypothetical protein complement(2522482..2523423) Lactococcus lactis subsp. cremoris MG1363 4797479 llmg_tRNA_01 tRNA llmg_tRNA_01 NC_009004.1 25648 25719 D tRNA-Glu 25648..25719 Lactococcus lactis subsp. cremoris MG1363 4798787 llmg_tRNA_02 tRNA llmg_tRNA_02 NC_009004.1 25725 25814 D tRNA-Ser 25725..25814 Lactococcus lactis subsp. cremoris MG1363 4796660 llmg_tRNA_03 tRNA llmg_tRNA_03 NC_009004.1 25825 25898 D tRNA-Met 25825..25898 Lactococcus lactis subsp. cremoris MG1363 4796901 llmg_tRNA_04 tRNA llmg_tRNA_04 NC_009004.1 25904 25976 D tRNA-Phe 25904..25976 Lactococcus lactis subsp. cremoris MG1363 4797075 llmg_tRNA_05 tRNA llmg_tRNA_05 NC_009004.1 25988 26058 D tRNA-Gly 25988..26058 Lactococcus lactis subsp. cremoris MG1363 4798176 llmg_tRNA_06 tRNA llmg_tRNA_06 NC_009004.1 26073 26146 D tRNA-Ile 26073..26146 Lactococcus lactis subsp. cremoris MG1363 4796729 llmg_tRNA_07 tRNA llmg_tRNA_07 NC_009004.1 26271 26344 D tRNA-Asn 26271..26344 Lactococcus lactis subsp. cremoris MG1363 4796632 llmg_tRNA_08 tRNA llmg_tRNA_08 NC_009004.1 60653 60725 D tRNA-Lys 60653..60725 Lactococcus lactis subsp. cremoris MG1363 4796647 llmg_tRNA_09 tRNA llmg_tRNA_09 NC_009004.1 123801 123889 R tRNA-Leu complement(123801..123889) Lactococcus lactis subsp. cremoris MG1363 4796777 llmg_tRNA_10 tRNA llmg_tRNA_10 NC_009004.1 133800 133886 R tRNA-Ser complement(133800..133886) Lactococcus lactis subsp. cremoris MG1363 4798907 llmg_tRNA_11 tRNA llmg_tRNA_11 NC_009004.1 154602 154677 R tRNA-Thr complement(154602..154677) Lactococcus lactis subsp. cremoris MG1363 4798901 llmg_tRNA_12 tRNA llmg_tRNA_12 NC_009004.1 252907 252995 R tRNA-Leu complement(252907..252995) Lactococcus lactis subsp. cremoris MG1363 4799129 llmg_tRNA_13 tRNA llmg_tRNA_13 NC_009004.1 275886 275973 R tRNA-Ser complement(275886..275973) Lactococcus lactis subsp. cremoris MG1363 4797795 llmg_tRNA_14 tRNA llmg_tRNA_14 NC_009004.1 283053 283126 D tRNA-Arg 283053..283126 Lactococcus lactis subsp. cremoris MG1363 4798939 llmg_tRNA_15 tRNA llmg_tRNA_15 NC_009004.1 283312 283385 D tRNA-Pro 283312..283385 Lactococcus lactis subsp. cremoris MG1363 4798754 llmg_tRNA_16 tRNA llmg_tRNA_16 NC_009004.1 433860 433930 D tRNA-Cys 433860..433930 Lactococcus lactis subsp. cremoris MG1363 4796948 llmg_tRNA_17 tRNA llmg_tRNA_17 NC_009004.1 456744 456817 D tRNA-Arg 456744..456817 Lactococcus lactis subsp. cremoris MG1363 4797634 llmg_tRNA_18 tRNA llmg_tRNA_18 NC_009004.1 513063 513135 D tRNA-Ala 513063..513135 Lactococcus lactis subsp. cremoris MG1363 4797576 llmg_tRNA_19 tRNA llmg_tRNA_19 NC_009004.1 516376 516448 D tRNA-Val 516376..516448 Lactococcus lactis subsp. cremoris MG1363 4798354 llmg_tRNA_20 tRNA llmg_tRNA_20 NC_009004.1 516478 516550 D tRNA-Asp 516478..516550 Lactococcus lactis subsp. cremoris MG1363 4796879 llmg_tRNA_21 tRNA llmg_tRNA_21 NC_009004.1 516568 516640 D tRNA-Lys 516568..516640 Lactococcus lactis subsp. cremoris MG1363 4798607 llmg_tRNA_22 tRNA llmg_tRNA_22 NC_009004.1 516650 516731 D tRNA-Leu 516650..516731 Lactococcus lactis subsp. cremoris MG1363 4796989 llmg_tRNA_23 tRNA llmg_tRNA_23 NC_009004.1 516745 516817 D tRNA-Thr 516745..516817 Lactococcus lactis subsp. cremoris MG1363 4796864 llmg_tRNA_24 tRNA llmg_tRNA_24 NC_009004.1 516843 516914 D tRNA-Gly 516843..516914 Lactococcus lactis subsp. cremoris MG1363 4797005 llmg_tRNA_25 tRNA llmg_tRNA_25 NC_009004.1 516953 517026 D tRNA-Arg 516953..517026 Lactococcus lactis subsp. cremoris MG1363 4796654 llmg_tRNA_26 tRNA llmg_tRNA_26 NC_009004.1 517032 517105 D tRNA-Pro 517032..517105 Lactococcus lactis subsp. cremoris MG1363 4796581 llmg_tRNA_27 tRNA llmg_tRNA_27 NC_009004.1 517143 517216 D tRNA-Met 517143..517216 Lactococcus lactis subsp. cremoris MG1363 4798122 llmg_tRNA_28 tRNA llmg_tRNA_28 NC_009004.1 517229 517302 D tRNA-Met 517229..517302 Lactococcus lactis subsp. cremoris MG1363 4796959 llmg_tRNA_29 tRNA llmg_tRNA_29 NC_009004.1 517310 517382 D tRNA-Phe 517310..517382 Lactococcus lactis subsp. cremoris MG1363 4796947 llmg_tRNA_30 tRNA llmg_tRNA_30 NC_009004.1 517393 517463 D tRNA-Gly 517393..517463 Lactococcus lactis subsp. cremoris MG1363 4796598 llmg_tRNA_31 tRNA llmg_tRNA_31 NC_009004.1 517489 517562 D tRNA-Ile 517489..517562 Lactococcus lactis subsp. cremoris MG1363 4796633 llmg_tRNA_32 tRNA llmg_tRNA_32 NC_009004.1 517605 517692 D tRNA-Ser 517605..517692 Lactococcus lactis subsp. cremoris MG1363 4796626 llmg_tRNA_33 tRNA llmg_tRNA_33 NC_009004.1 583292 583363 D tRNA-Arg 583292..583363 Lactococcus lactis subsp. cremoris MG1363 4799032 llmg_tRNA_34 tRNA llmg_tRNA_34 NC_009004.1 591544 591619 D tRNA-Lys 591544..591619 Lactococcus lactis subsp. cremoris MG1363 4798526 llmg_tRNA_35 tRNA llmg_tRNA_35 NC_009004.1 749856 749928 R tRNA-Arg complement(749856..749928) Lactococcus lactis subsp. cremoris MG1363 4797893 llmg_tRNA_36 tRNA llmg_tRNA_36 NC_009004.1 770595 770666 D tRNA-Gln 770595..770666 Lactococcus lactis subsp. cremoris MG1363 4796792 llmg_tRNA_37 tRNA llmg_tRNA_37 NC_009004.1 869644 869733 D tRNA-Ser 869644..869733 Lactococcus lactis subsp. cremoris MG1363 4797285 llmg_tRNA_38 tRNA llmg_tRNA_38 NC_009004.1 1226392 1226465 D tRNA-Met 1226392..1226465 Lactococcus lactis subsp. cremoris MG1363 4797416 llmg_tRNA_39 tRNA llmg_tRNA_39 NC_009004.1 1827876 1827949 R tRNA-Met complement(1827876..1827949) Lactococcus lactis subsp. cremoris MG1363 4797979 llmg_tRNA_40 tRNA llmg_tRNA_40 NC_009004.1 2089171 2089241 R tRNA-Lys complement(2089171..2089241) Lactococcus lactis subsp. cremoris MG1363 4796904 llmg_tRNA_41 tRNA llmg_tRNA_41 NC_009004.1 2130238 2130323 R tRNA-Leu complement(2130238..2130323) Lactococcus lactis subsp. cremoris MG1363 4797352 llmg_tRNA_42 tRNA llmg_tRNA_42 NC_009004.1 2130358 2130429 R tRNA-Gly complement(2130358..2130429) Lactococcus lactis subsp. cremoris MG1363 4799097 llmg_tRNA_43 tRNA llmg_tRNA_43 NC_009004.1 2130455 2130527 R tRNA-Thr complement(2130455..2130527) Lactococcus lactis subsp. cremoris MG1363 4796619 llmg_tRNA_44 tRNA llmg_tRNA_44 NC_009004.1 2130541 2130622 R tRNA-Leu complement(2130541..2130622) Lactococcus lactis subsp. cremoris MG1363 4798200 llmg_tRNA_45 tRNA llmg_tRNA_45 NC_009004.1 2130632 2130704 R tRNA-Lys complement(2130632..2130704) Lactococcus lactis subsp. cremoris MG1363 4799119 llmg_tRNA_46 tRNA llmg_tRNA_46 NC_009004.1 2130722 2130794 R tRNA-Asp complement(2130722..2130794) Lactococcus lactis subsp. cremoris MG1363 4797045 llmg_tRNA_47 tRNA llmg_tRNA_47 NC_009004.1 2130824 2130896 R tRNA-Val complement(2130824..2130896) Lactococcus lactis subsp. cremoris MG1363 4797466 llmg_tRNA_48 tRNA llmg_tRNA_48 NC_009004.1 2134137 2134209 R tRNA-Ala complement(2134137..2134209) Lactococcus lactis subsp. cremoris MG1363 4798353 llmg_tRNA_49 tRNA llmg_tRNA_49 NC_009004.1 2310690 2310762 R tRNA-Thr complement(2310690..2310762) Lactococcus lactis subsp. cremoris MG1363 4798585 llmg_tRNA_50 tRNA llmg_tRNA_50 NC_009004.1 2374727 2374799 R tRNA-Ala complement(2374727..2374799) Lactococcus lactis subsp. cremoris MG1363 4798753 llmg_tRNA_51 tRNA llmg_tRNA_51 NC_009004.1 2422096 2422168 R tRNA-Ala complement(2422096..2422168) Lactococcus lactis subsp. cremoris MG1363 4798802 llmg_tRNA_52 tRNA llmg_tRNA_52 NC_009004.1 2452228 2452310 R tRNA-Leu complement(2452228..2452310) Lactococcus lactis subsp. cremoris MG1363 4796899 llmg_tRNA_53 tRNA llmg_tRNA_53 NC_009004.1 2499667 2499750 R tRNA-Leu complement(2499667..2499750) Lactococcus lactis subsp. cremoris MG1363 4796886 llmg_tRNA_54 tRNA llmg_tRNA_54 NC_009004.1 2499763 2499834 R tRNA-Gln complement(2499763..2499834) Lactococcus lactis subsp. cremoris MG1363 4798234 llmg_tRNA_55 tRNA llmg_tRNA_55 NC_009004.1 2499844 2499916 R tRNA-His complement(2499844..2499916) Lactococcus lactis subsp. cremoris MG1363 4798547 llmg_tRNA_56 tRNA llmg_tRNA_56 NC_009004.1 2499928 2499998 R tRNA-Trp complement(2499928..2499998) Lactococcus lactis subsp. cremoris MG1363 4796725 llmg_tRNA_57 tRNA llmg_tRNA_57 NC_009004.1 2500015 2500095 R tRNA-Tyr complement(2500015..2500095) Lactococcus lactis subsp. cremoris MG1363 4796922 llmg_tRNA_58 tRNA llmg_tRNA_58 NC_009004.1 2500131 2500203 R tRNA-Val complement(2500131..2500203) Lactococcus lactis subsp. cremoris MG1363 4796567 llmg_tRNA_59 tRNA llmg_tRNA_59 NC_009004.1 2503444 2503516 R tRNA-Ala complement(2503444..2503516) Lactococcus lactis subsp. cremoris MG1363 4798828 llmg_tRNA_60 tRNA llmg_tRNA_60 NC_009004.1 2523520 2523593 R tRNA-Asn complement(2523520..2523593) Lactococcus lactis subsp. cremoris MG1363 4797487 llmg_tRNA_61 tRNA llmg_tRNA_61 NC_009004.1 2523630 2523701 R tRNA-Glu complement(2523630..2523701) Lactococcus lactis subsp. cremoris MG1363 4799043 llmg_tRNA_62 tRNA llmg_tRNA_62 NC_009004.1 2526949 2527021 R tRNA-Ala complement(2526949..2527021) Lactococcus lactis subsp. cremoris MG1363 4798334 llmg_tRNA_06a rRNA llmg_tRNA_06a NC_009004.1 26149 26264 D 5S ribosomal RNA 26149..26264 Lactococcus lactis subsp. cremoris MG1363 5309718 llmg_rRNA_1 rRNA llmg_rRNA_1 NC_009004.1 511423 512971 D 16S ribosomal RNA 511423..512971 Lactococcus lactis subsp. cremoris MG1363 4796931 llmg_rRNA_2 rRNA llmg_rRNA_2 NC_009004.1 513274 516175 D 23S ribosomal RNA 513274..516175 Lactococcus lactis subsp. cremoris MG1363 4797448 llmg_rRNA_2a rRNA llmg_rRNA_2a NC_009004.1 516258 516373 D 5S ribosomal RNA 516258..516373 Lactococcus lactis subsp. cremoris MG1363 5309715 llmg_rRNA_48b rRNA llmg_rRNA_48b NC_009004.1 2130899 2131014 R 5S ribosomal RNA complement(2130899..2131014) Lactococcus lactis subsp. cremoris MG1363 5469468 llmg_rRNA_48c rRNA llmg_rRNA_48c NC_009004.1 2131097 2133998 R 23S ribosomal RNA complement(2131097..2133998) Lactococcus lactis subsp. cremoris MG1363 5469469 llmg_rRNA_48a rRNA llmg_rRNA_48a NC_009004.1 2134301 2135851 R 16S ribosomal RNA complement(2134301..2135851) Lactococcus lactis subsp. cremoris MG1363 5309709 llmg_2426a rRNA llmg_2426a NC_009004.1 2371489 2371604 R 5S ribosomal RNA complement(2371489..2371604) Lactococcus lactis subsp. cremoris MG1363 5309713 llmg_rRNA_4 rRNA llmg_rRNA_4 NC_009004.1 2371687 2374588 R 23S ribosomal RNA complement(2371687..2374588) Lactococcus lactis subsp. cremoris MG1363 4798860 llmg_rRNA_4a rRNA llmg_rRNA_4a NC_009004.1 2374891 2376441 R 16S ribosomal RNA complement(2374891..2376441) Lactococcus lactis subsp. cremoris MG1363 5309716 llmg_2466a rRNA llmg_2466a NC_009004.1 2418858 2418973 R 5S ribosomal RNA complement(2418858..2418973) Lactococcus lactis subsp. cremoris MG1363 5309711 llmg_rRNA_5 rRNA llmg_rRNA_5 NC_009004.1 2419056 2421957 R 23S ribosomal RNA complement(2419056..2421957) Lactococcus lactis subsp. cremoris MG1363 4796912 llmg_rRNA_5a rRNA llmg_rRNA_5a NC_009004.1 2422260 2423810 R 16S ribosomal RNA complement(2422260..2423810) Lactococcus lactis subsp. cremoris MG1363 5309712 llmg_rRNA_6a rRNA llmg_rRNA_6a NC_009004.1 2500206 2500321 R 5S ribosomal RNA complement(2500206..2500321) Lactococcus lactis subsp. cremoris MG1363 5469470 llmg_rRNA_6 rRNA llmg_rRNA_6 NC_009004.1 2500404 2503305 R 23S ribosomal RNA complement(2500404..2503305) Lactococcus lactis subsp. cremoris MG1363 4796980 llmg_rRNA_6b rRNA llmg_rRNA_6b NC_009004.1 2503608 2505158 R 16S ribosomal RNA complement(2503608..2505158) Lactococcus lactis subsp. cremoris MG1363 5309717 llmg_rRNA_60a rRNA llmg_rRNA_60a NC_009004.1 2523711 2523826 R 5S ribosomal RNA complement(2523711..2523826) Lactococcus lactis subsp. cremoris MG1363 5309710 llmg_rRNA_7 rRNA llmg_rRNA_7 NC_009004.1 2523909 2526810 R 23S ribosomal RNA complement(2523909..2526810) Lactococcus lactis subsp. cremoris MG1363 4796728 llmg_rRNA_7a rRNA llmg_rRNA_7a NC_009004.1 2527113 2528663 R 16S ribosomal RNA complement(2527113..2528663) Lactococcus lactis subsp. cremoris MG1363 5309714