-- dump date 20140619_125401 -- class Genbank::misc_feature -- table misc_feature_note -- id note 746361000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 746361000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361000003 Walker A motif; other site 746361000004 ATP binding site [chemical binding]; other site 746361000005 Walker B motif; other site 746361000006 arginine finger; other site 746361000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 746361000008 DnaA box-binding interface [nucleotide binding]; other site 746361000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 746361000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 746361000011 putative DNA binding surface [nucleotide binding]; other site 746361000012 dimer interface [polypeptide binding]; other site 746361000013 beta-clamp/clamp loader binding surface; other site 746361000014 beta-clamp/translesion DNA polymerase binding surface; other site 746361000015 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 746361000016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 746361000017 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 746361000018 Part of AAA domain; Region: AAA_19; pfam13245 746361000019 Family description; Region: UvrD_C_2; pfam13538 746361000020 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 746361000021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361000022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000023 non-specific DNA binding site [nucleotide binding]; other site 746361000024 salt bridge; other site 746361000025 sequence-specific DNA binding site [nucleotide binding]; other site 746361000026 GTP-binding protein YchF; Reviewed; Region: PRK09601 746361000027 YchF GTPase; Region: YchF; cd01900 746361000028 G1 box; other site 746361000029 GTP/Mg2+ binding site [chemical binding]; other site 746361000030 Switch I region; other site 746361000031 G2 box; other site 746361000032 Switch II region; other site 746361000033 G3 box; other site 746361000034 G4 box; other site 746361000035 G5 box; other site 746361000036 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 746361000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000038 non-specific DNA binding site [nucleotide binding]; other site 746361000039 salt bridge; other site 746361000040 sequence-specific DNA binding site [nucleotide binding]; other site 746361000041 topology modulation protein; Reviewed; Region: PRK08118 746361000042 AAA domain; Region: AAA_17; pfam13207 746361000043 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 746361000044 putative active site [active] 746361000045 catalytic residue [active] 746361000046 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 746361000047 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 746361000048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361000049 ATP binding site [chemical binding]; other site 746361000050 putative Mg++ binding site [ion binding]; other site 746361000051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361000052 nucleotide binding region [chemical binding]; other site 746361000053 ATP-binding site [chemical binding]; other site 746361000054 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 746361000055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361000056 RNA binding surface [nucleotide binding]; other site 746361000057 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 746361000058 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746361000059 RNA binding site [nucleotide binding]; other site 746361000060 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 746361000061 SH3-like domain; Region: SH3_8; pfam13457 746361000062 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 746361000063 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 746361000064 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 746361000065 Ligand Binding Site [chemical binding]; other site 746361000066 TilS substrate C-terminal domain; Region: TilS_C; smart00977 746361000067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361000068 active site 746361000069 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 746361000070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361000071 Walker A motif; other site 746361000072 ATP binding site [chemical binding]; other site 746361000073 Walker B motif; other site 746361000074 arginine finger; other site 746361000075 Peptidase family M41; Region: Peptidase_M41; pfam01434 746361000076 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 746361000077 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 746361000078 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 746361000079 active site 746361000080 P-loop; other site 746361000081 phosphorylation site [posttranslational modification] 746361000082 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 746361000083 active site 746361000084 P-loop; other site 746361000085 phosphorylation site [posttranslational modification] 746361000086 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 746361000087 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 746361000088 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 746361000089 active site 746361000090 P-loop; other site 746361000091 phosphorylation site [posttranslational modification] 746361000092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 746361000093 active site 746361000094 phosphorylation site [posttranslational modification] 746361000095 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 746361000096 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 746361000097 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 746361000098 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 746361000099 Phage associated DNA primase [General function prediction only]; Region: COG3378 746361000100 D5 N terminal like; Region: D5_N; smart00885 746361000101 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 746361000102 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 746361000103 polymerase nucleotide-binding site; other site 746361000104 DNA-binding residues [nucleotide binding]; DNA binding site 746361000105 nucleotide binding site [chemical binding]; other site 746361000106 primase nucleotide-binding site [nucleotide binding]; other site 746361000107 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 746361000108 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 746361000109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361000111 non-specific DNA binding site [nucleotide binding]; other site 746361000112 salt bridge; other site 746361000113 sequence-specific DNA binding site [nucleotide binding]; other site 746361000114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361000115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000116 salt bridge; other site 746361000117 non-specific DNA binding site [nucleotide binding]; other site 746361000118 sequence-specific DNA binding site [nucleotide binding]; other site 746361000119 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 746361000120 MepB protein; Region: MepB; cl01985 746361000121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361000122 Integrase core domain; Region: rve; pfam00665 746361000123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361000124 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361000125 Walker A motif; other site 746361000126 ATP binding site [chemical binding]; other site 746361000127 Walker B motif; other site 746361000128 arginine finger; other site 746361000129 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361000130 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 746361000131 Int/Topo IB signature motif; other site 746361000132 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 746361000133 PGAP1-like protein; Region: PGAP1; pfam07819 746361000134 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 746361000135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 746361000136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000137 Coenzyme A binding pocket [chemical binding]; other site 746361000138 TM2 domain; Region: TM2; cl00984 746361000139 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 746361000140 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 746361000141 Sulfate transporter family; Region: Sulfate_transp; pfam00916 746361000142 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 746361000143 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361000144 MULE transposase domain; Region: MULE; pfam10551 746361000145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000146 Coenzyme A binding pocket [chemical binding]; other site 746361000147 aromatic amino acid aminotransferase; Validated; Region: PRK07309 746361000148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361000150 homodimer interface [polypeptide binding]; other site 746361000151 catalytic residue [active] 746361000152 Recombination protein O N terminal; Region: RecO_N; pfam11967 746361000153 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 746361000154 Recombination protein O C terminal; Region: RecO_C; pfam02565 746361000155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000156 non-specific DNA binding site [nucleotide binding]; other site 746361000157 salt bridge; other site 746361000158 sequence-specific DNA binding site [nucleotide binding]; other site 746361000159 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361000160 MFS/sugar transport protein; Region: MFS_2; pfam13347 746361000161 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 746361000162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746361000163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361000164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361000165 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746361000166 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 746361000167 E3 interaction surface; other site 746361000168 lipoyl attachment site [posttranslational modification]; other site 746361000169 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746361000170 E3 interaction surface; other site 746361000171 lipoyl attachment site [posttranslational modification]; other site 746361000172 e3 binding domain; Region: E3_binding; pfam02817 746361000173 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 746361000174 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 746361000175 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 746361000176 TPP binding site [chemical binding]; other site 746361000177 alpha subunit interface [polypeptide binding]; other site 746361000178 heterodimer interface [polypeptide binding]; other site 746361000179 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746361000180 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 746361000181 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 746361000182 tetramer interface [polypeptide binding]; other site 746361000183 TPP-binding site [chemical binding]; other site 746361000184 heterodimer interface [polypeptide binding]; other site 746361000185 phosphorylation loop region [posttranslational modification] 746361000186 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 746361000187 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 746361000188 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 746361000189 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 746361000190 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 746361000191 active site 746361000192 catalytic site [active] 746361000193 metal binding site [ion binding]; metal-binding site 746361000194 dimer interface [polypeptide binding]; other site 746361000195 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 746361000196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361000197 Zn2+ binding site [ion binding]; other site 746361000198 Mg2+ binding site [ion binding]; other site 746361000199 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 746361000200 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 746361000201 active site 746361000202 HIGH motif; other site 746361000203 dimer interface [polypeptide binding]; other site 746361000204 KMSKS motif; other site 746361000205 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 746361000206 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 746361000207 putative phosphate acyltransferase; Provisional; Region: PRK05331 746361000208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 746361000209 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361000210 active site 746361000211 motif I; other site 746361000212 motif II; other site 746361000213 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361000214 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 746361000215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361000216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361000217 ABC transporter; Region: ABC_tran_2; pfam12848 746361000218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361000219 yiaA/B two helix domain; Region: YiaAB; pfam05360 746361000220 short chain dehydrogenase; Validated; Region: PRK06182 746361000221 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 746361000222 NADP binding site [chemical binding]; other site 746361000223 active site 746361000224 steroid binding site; other site 746361000225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361000226 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361000227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361000228 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361000229 HTH-like domain; Region: HTH_21; pfam13276 746361000230 Integrase core domain; Region: rve; pfam00665 746361000231 Integrase core domain; Region: rve_2; pfam13333 746361000232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361000233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361000234 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 746361000235 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746361000236 homodimer interface [polypeptide binding]; other site 746361000237 substrate-cofactor binding pocket; other site 746361000238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361000239 catalytic residue [active] 746361000240 short chain dehydrogenase; Validated; Region: PRK06182 746361000241 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 746361000242 NADP binding site [chemical binding]; other site 746361000243 active site 746361000244 steroid binding site; other site 746361000245 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361000246 Ligand Binding Site [chemical binding]; other site 746361000247 Predicted esterase [General function prediction only]; Region: COG0400 746361000248 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 746361000249 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361000250 Zn binding site [ion binding]; other site 746361000251 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 746361000252 Zn binding site [ion binding]; other site 746361000253 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 746361000254 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 746361000255 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 746361000256 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 746361000257 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361000258 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746361000259 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 746361000260 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746361000261 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746361000262 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 746361000263 ParB-like nuclease domain; Region: ParBc; pfam02195 746361000264 KorB domain; Region: KorB; pfam08535 746361000265 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 746361000266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361000267 Walker A motif; other site 746361000268 ATP binding site [chemical binding]; other site 746361000269 Walker B motif; other site 746361000270 arginine finger; other site 746361000271 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 746361000272 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 746361000273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000274 Coenzyme A binding pocket [chemical binding]; other site 746361000275 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 746361000276 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746361000277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361000278 Walker A/P-loop; other site 746361000279 ATP binding site [chemical binding]; other site 746361000280 Q-loop/lid; other site 746361000281 ABC transporter signature motif; other site 746361000282 Walker B; other site 746361000283 D-loop; other site 746361000284 H-loop/switch region; other site 746361000285 ABC transporter; Region: ABC_tran_2; pfam12848 746361000286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361000287 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 746361000288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361000289 S-adenosylmethionine binding site [chemical binding]; other site 746361000290 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 746361000291 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 746361000292 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 746361000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361000294 S-adenosylmethionine binding site [chemical binding]; other site 746361000295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 746361000296 RNA methyltransferase, RsmE family; Region: TIGR00046 746361000297 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746361000298 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 746361000299 putative active site [active] 746361000300 putative metal binding site [ion binding]; other site 746361000301 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 746361000302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361000303 Zn2+ binding site [ion binding]; other site 746361000304 Mg2+ binding site [ion binding]; other site 746361000305 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 746361000306 synthetase active site [active] 746361000307 NTP binding site [chemical binding]; other site 746361000308 metal binding site [ion binding]; metal-binding site 746361000309 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 746361000310 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 746361000311 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 746361000312 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 746361000313 Ligand binding site; other site 746361000314 Putative Catalytic site; other site 746361000315 DXD motif; other site 746361000316 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 746361000317 putative active site [active] 746361000318 dimerization interface [polypeptide binding]; other site 746361000319 putative tRNAtyr binding site [nucleotide binding]; other site 746361000320 Predicted integral membrane protein [Function unknown]; Region: COG3548 746361000321 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 746361000322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361000323 amino acid transporter; Region: 2A0306; TIGR00909 746361000324 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 746361000325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746361000326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 746361000327 putative acyl-acceptor binding pocket; other site 746361000328 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361000329 MarR family; Region: MarR_2; pfam12802 746361000330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361000331 Transposase; Region: HTH_Tnp_1; pfam01527 746361000332 putative transposase OrfB; Reviewed; Region: PHA02517 746361000333 HTH-like domain; Region: HTH_21; pfam13276 746361000334 Integrase core domain; Region: rve; pfam00665 746361000335 Integrase core domain; Region: rve_3; pfam13683 746361000336 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 746361000337 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 746361000338 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 746361000339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361000340 nucleotide binding region [chemical binding]; other site 746361000341 ATP-binding site [chemical binding]; other site 746361000342 SEC-C motif; Region: SEC-C; pfam02810 746361000343 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 746361000344 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 746361000345 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 746361000346 dimerization domain swap beta strand [polypeptide binding]; other site 746361000347 regulatory protein interface [polypeptide binding]; other site 746361000348 active site 746361000349 regulatory phosphorylation site [posttranslational modification]; other site 746361000350 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 746361000351 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 746361000352 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 746361000353 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 746361000354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 746361000355 potential protein location (hypothetical protein LLNZ_00665 [Lactococcus lactis subsp. cremoris NZ9000]) that overlaps RNA (tRNA-L) 746361000356 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746361000357 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746361000358 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746361000359 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 746361000360 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 746361000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361000362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361000363 putative substrate translocation pore; other site 746361000364 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 746361000365 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 746361000366 Ligand binding site; other site 746361000367 Putative Catalytic site; other site 746361000368 DXD motif; other site 746361000369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361000370 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 746361000371 ATP binding site [chemical binding]; other site 746361000372 Mg2+ binding site [ion binding]; other site 746361000373 G-X-G motif; other site 746361000374 conserved hypothetical integral membrane protein; Region: TIGR03766 746361000375 potential protein location (hypothetical protein LLNZ_00725 [Lactococcus lactis subsp. cremoris NZ9000]) that overlaps RNA (tRNA-S) 746361000376 argininosuccinate synthase; Provisional; Region: PRK13820 746361000377 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 746361000378 ANP binding site [chemical binding]; other site 746361000379 Substrate Binding Site II [chemical binding]; other site 746361000380 Substrate Binding Site I [chemical binding]; other site 746361000381 argininosuccinate lyase; Provisional; Region: PRK00855 746361000382 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 746361000383 active sites [active] 746361000384 tetramer interface [polypeptide binding]; other site 746361000385 drug efflux system protein MdtG; Provisional; Region: PRK09874 746361000386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361000387 putative substrate translocation pore; other site 746361000388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361000389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361000390 WHG domain; Region: WHG; pfam13305 746361000391 ribonuclease P; Reviewed; Region: rnpA; PRK00499 746361000392 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 746361000393 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 746361000394 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 746361000395 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 746361000396 G-X-X-G motif; other site 746361000397 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 746361000398 RxxxH motif; other site 746361000399 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 746361000400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746361000401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746361000402 active site 746361000403 catalytic tetrad [active] 746361000404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000405 non-specific DNA binding site [nucleotide binding]; other site 746361000406 salt bridge; other site 746361000407 sequence-specific DNA binding site [nucleotide binding]; other site 746361000408 CAAX protease self-immunity; Region: Abi; pfam02517 746361000409 hypothetical protein; Provisional; Region: PRK05473 746361000410 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 746361000411 hypothetical protein; Provisional; Region: PRK13678 746361000412 Predicted integral membrane protein [Function unknown]; Region: COG3548 746361000413 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 746361000414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361000415 NAD(P) binding site [chemical binding]; other site 746361000416 active site 746361000417 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 746361000418 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 746361000419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361000420 NAD(P) binding site [chemical binding]; other site 746361000421 active site 746361000422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361000423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361000424 putative DNA binding site [nucleotide binding]; other site 746361000425 putative Zn2+ binding site [ion binding]; other site 746361000426 glycogen branching enzyme; Provisional; Region: PRK12313 746361000427 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 746361000428 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 746361000429 active site 746361000430 catalytic site [active] 746361000431 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 746361000432 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 746361000433 putative FMN binding site [chemical binding]; other site 746361000434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361000435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361000436 Collagen binding domain; Region: Collagen_bind; pfam05737 746361000437 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361000438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000439 non-specific DNA binding site [nucleotide binding]; other site 746361000440 salt bridge; other site 746361000441 sequence-specific DNA binding site [nucleotide binding]; other site 746361000442 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 746361000443 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 746361000444 Protein of unknown function (DUF975); Region: DUF975; cl10504 746361000445 potential frameshift: common BLAST hit: gi|116510986|ref|YP_808202.1| major facilitator superfamily permease 746361000446 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 746361000447 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 746361000448 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 746361000449 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 746361000450 aminotransferase AlaT; Validated; Region: PRK09265 746361000451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361000452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361000453 homodimer interface [polypeptide binding]; other site 746361000454 catalytic residue [active] 746361000455 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 746361000456 CodY GAF-like domain; Region: CodY; pfam06018 746361000457 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 746361000458 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 746361000459 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 746361000460 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 746361000461 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 746361000462 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 746361000463 GatB domain; Region: GatB_Yqey; pfam02637 746361000464 amidase; Provisional; Region: PRK06529 746361000465 Amidase; Region: Amidase; cl11426 746361000466 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 746361000467 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 746361000468 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361000469 DNA-binding site [nucleotide binding]; DNA binding site 746361000470 RNA-binding motif; other site 746361000471 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 746361000472 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 746361000473 Rhomboid family; Region: Rhomboid; pfam01694 746361000474 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 746361000475 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 746361000476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361000477 active site 746361000478 metal binding site [ion binding]; metal-binding site 746361000479 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 746361000480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 746361000481 Uncharacterized conserved protein [Function unknown]; Region: COG3589 746361000482 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 746361000483 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 746361000484 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 746361000485 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 746361000486 beta-galactosidase; Region: BGL; TIGR03356 746361000487 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 746361000488 trimer interface [polypeptide binding]; other site 746361000489 active site 746361000490 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 746361000491 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 746361000492 active site 746361000493 metal binding site [ion binding]; metal-binding site 746361000494 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 746361000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 746361000496 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 746361000497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361000498 FeS/SAM binding site; other site 746361000499 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 746361000500 dimer interface [polypeptide binding]; other site 746361000501 FMN binding site [chemical binding]; other site 746361000502 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 746361000503 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 746361000504 substrate binding pocket [chemical binding]; other site 746361000505 chain length determination region; other site 746361000506 substrate-Mg2+ binding site; other site 746361000507 catalytic residues [active] 746361000508 aspartate-rich region 1; other site 746361000509 active site lid residues [active] 746361000510 aspartate-rich region 2; other site 746361000511 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 746361000512 UbiA prenyltransferase family; Region: UbiA; pfam01040 746361000513 CAAX protease self-immunity; Region: Abi; pfam02517 746361000514 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 746361000515 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 746361000516 G1 box; other site 746361000517 GTP/Mg2+ binding site [chemical binding]; other site 746361000518 Switch I region; other site 746361000519 G2 box; other site 746361000520 G3 box; other site 746361000521 Switch II region; other site 746361000522 G4 box; other site 746361000523 G5 box; other site 746361000524 Nucleoside recognition; Region: Gate; pfam07670 746361000525 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 746361000526 Nucleoside recognition; Region: Gate; pfam07670 746361000527 FeoA domain; Region: FeoA; pfam04023 746361000528 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 746361000529 methionine sulfoxide reductase B; Provisional; Region: PRK00222 746361000530 SelR domain; Region: SelR; pfam01641 746361000531 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 746361000532 DAK2 domain; Region: Dak2; pfam02734 746361000533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 746361000534 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 746361000535 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 746361000536 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 746361000537 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 746361000538 substrate binding site; other site 746361000539 tetramer interface; other site 746361000540 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 746361000541 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 746361000542 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 746361000543 NAD binding site [chemical binding]; other site 746361000544 substrate binding site [chemical binding]; other site 746361000545 homodimer interface [polypeptide binding]; other site 746361000546 active site 746361000547 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 746361000548 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 746361000549 NADP binding site [chemical binding]; other site 746361000550 active site 746361000551 putative substrate binding site [chemical binding]; other site 746361000552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746361000553 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 746361000554 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746361000555 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 746361000556 Probable Catalytic site; other site 746361000557 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 746361000558 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 746361000559 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 746361000560 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 746361000561 Walker A/P-loop; other site 746361000562 ATP binding site [chemical binding]; other site 746361000563 Q-loop/lid; other site 746361000564 ABC transporter signature motif; other site 746361000565 Walker B; other site 746361000566 D-loop; other site 746361000567 H-loop/switch region; other site 746361000568 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 746361000569 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746361000570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361000571 active site 746361000572 Rhamnan synthesis protein F; Region: RgpF; pfam05045 746361000573 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 746361000574 Ligand binding site; other site 746361000575 Putative Catalytic site; other site 746361000576 DXD motif; other site 746361000577 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 746361000578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746361000579 active site 746361000580 putative glycosyl transferase; Provisional; Region: PRK10073 746361000581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361000582 active site 746361000583 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 746361000584 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 746361000585 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746361000586 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 746361000587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746361000588 UDP-galactopyranose mutase; Region: GLF; pfam03275 746361000589 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 746361000590 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 746361000591 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 746361000592 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 746361000593 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 746361000594 active site 746361000595 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 746361000596 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 746361000597 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 746361000598 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 746361000599 active site 746361000600 GTPase YqeH; Provisional; Region: PRK13796 746361000601 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 746361000602 GTP/Mg2+ binding site [chemical binding]; other site 746361000603 G4 box; other site 746361000604 G5 box; other site 746361000605 G1 box; other site 746361000606 Switch I region; other site 746361000607 G2 box; other site 746361000608 G3 box; other site 746361000609 Switch II region; other site 746361000610 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 746361000611 nudix motif; other site 746361000612 GTPases [General function prediction only]; Region: HflX; COG2262 746361000613 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 746361000614 HflX GTPase family; Region: HflX; cd01878 746361000615 G1 box; other site 746361000616 GTP/Mg2+ binding site [chemical binding]; other site 746361000617 Switch I region; other site 746361000618 G2 box; other site 746361000619 G3 box; other site 746361000620 Switch II region; other site 746361000621 G4 box; other site 746361000622 G5 box; other site 746361000623 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 746361000624 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 746361000625 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 746361000626 active site 746361000627 (T/H)XGH motif; other site 746361000628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361000629 Zn2+ binding site [ion binding]; other site 746361000630 Mg2+ binding site [ion binding]; other site 746361000631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000632 Coenzyme A binding pocket [chemical binding]; other site 746361000633 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 746361000634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361000635 S-adenosylmethionine binding site [chemical binding]; other site 746361000636 hypothetical protein; Provisional; Region: PRK13670 746361000637 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 746361000638 hypothetical protein; Provisional; Region: PRK12378 746361000639 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 746361000640 ligand binding site [chemical binding]; other site 746361000641 active site 746361000642 UGI interface [polypeptide binding]; other site 746361000643 catalytic site [active] 746361000644 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 746361000645 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 746361000646 putative NAD(P) binding site [chemical binding]; other site 746361000647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361000648 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746361000649 NAD(P) binding site [chemical binding]; other site 746361000650 active site 746361000651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746361000652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361000653 NAD(P) binding site [chemical binding]; other site 746361000654 active site 746361000655 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 746361000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361000657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361000658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361000659 putative substrate translocation pore; other site 746361000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361000661 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361000662 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 746361000663 DNA binding residues [nucleotide binding] 746361000664 putative dimer interface [polypeptide binding]; other site 746361000665 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 746361000666 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361000667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361000668 active site 746361000669 motif I; other site 746361000670 motif II; other site 746361000671 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361000672 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 746361000673 Phosphoglycerate kinase; Region: PGK; pfam00162 746361000674 substrate binding site [chemical binding]; other site 746361000675 hinge regions; other site 746361000676 ADP binding site [chemical binding]; other site 746361000677 catalytic site [active] 746361000678 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 746361000679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361000680 motif II; other site 746361000681 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 746361000682 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 746361000683 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 746361000684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361000685 potential frameshift: common BLAST hit: gi|281490737|ref|YP_003352717.1| PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding 746361000686 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 746361000687 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 746361000688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 746361000689 potential frameshift: common BLAST hit: gi|116511076|ref|YP_808292.1| glycerol uptake facilitator related permease (major Intrinsic 746361000690 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 746361000691 potential frameshift: common BLAST hit: gi|116511077|ref|YP_808293.1| ABC-type multidrug transport system, ATPase component 746361000692 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 746361000693 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 746361000694 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 746361000695 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 746361000696 putative RNA binding site [nucleotide binding]; other site 746361000697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 746361000698 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 746361000699 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 746361000700 HI0933-like protein; Region: HI0933_like; pfam03486 746361000701 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 746361000702 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 746361000703 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 746361000704 putative substrate binding site [chemical binding]; other site 746361000705 putative ATP binding site [chemical binding]; other site 746361000706 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 746361000707 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361000708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361000709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361000710 Walker A/P-loop; other site 746361000711 ATP binding site [chemical binding]; other site 746361000712 Q-loop/lid; other site 746361000713 ABC transporter signature motif; other site 746361000714 Walker B; other site 746361000715 D-loop; other site 746361000716 H-loop/switch region; other site 746361000717 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361000718 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361000719 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 746361000720 Walker A/P-loop; other site 746361000721 ATP binding site [chemical binding]; other site 746361000722 Q-loop/lid; other site 746361000723 ABC transporter signature motif; other site 746361000724 Walker B; other site 746361000725 D-loop; other site 746361000726 H-loop/switch region; other site 746361000727 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 746361000728 putative oxidoreductase; Provisional; Region: PRK10206 746361000729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746361000730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 746361000731 S-ribosylhomocysteinase; Provisional; Region: PRK02260 746361000732 potential frameshift: common BLAST hit: gi|281490756|ref|YP_003352736.1| Transcription activator 746361000733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746361000734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746361000735 active site 746361000736 catalytic tetrad [active] 746361000737 Isochorismatase family; Region: Isochorismatase; pfam00857 746361000738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 746361000739 catalytic triad [active] 746361000740 conserved cis-peptide bond; other site 746361000741 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 746361000742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361000743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361000744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361000745 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 746361000746 ATP cone domain; Region: ATP-cone; pfam03477 746361000747 Class III ribonucleotide reductase; Region: RNR_III; cd01675 746361000748 effector binding site; other site 746361000749 active site 746361000750 Zn binding site [ion binding]; other site 746361000751 glycine loop; other site 746361000752 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 746361000753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361000754 FeS/SAM binding site; other site 746361000755 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 746361000756 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 746361000757 potential frameshift: common BLAST hit: gi|116511100|ref|YP_808316.1| phosphopyruvate hydratase 746361000758 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 746361000759 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 746361000760 Walker A/P-loop; other site 746361000761 ATP binding site [chemical binding]; other site 746361000762 Q-loop/lid; other site 746361000763 ABC transporter signature motif; other site 746361000764 Walker B; other site 746361000765 D-loop; other site 746361000766 H-loop/switch region; other site 746361000767 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 746361000768 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 746361000769 Walker A/P-loop; other site 746361000770 ATP binding site [chemical binding]; other site 746361000771 Q-loop/lid; other site 746361000772 ABC transporter signature motif; other site 746361000773 Walker B; other site 746361000774 D-loop; other site 746361000775 H-loop/switch region; other site 746361000776 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 746361000777 active site 746361000778 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 746361000779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 746361000780 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 746361000781 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 746361000782 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 746361000783 putative trimer interface [polypeptide binding]; other site 746361000784 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 746361000785 putative CoA binding site [chemical binding]; other site 746361000786 putative trimer interface [polypeptide binding]; other site 746361000787 putative CoA binding site [chemical binding]; other site 746361000788 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 746361000789 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 746361000790 metal binding site [ion binding]; metal-binding site 746361000791 putative dimer interface [polypeptide binding]; other site 746361000792 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746361000793 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 746361000794 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 746361000795 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 746361000796 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 746361000797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361000798 RNA binding surface [nucleotide binding]; other site 746361000799 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 746361000800 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 746361000801 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 746361000802 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 746361000803 RNA binding site [nucleotide binding]; other site 746361000804 SprT homologues; Region: SprT; cl01182 746361000805 hypothetical protein; Provisional; Region: PRK04351 746361000806 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 746361000807 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 746361000808 active site 746361000809 purine riboside binding site [chemical binding]; other site 746361000810 SnoaL-like domain; Region: SnoaL_4; pfam13577 746361000811 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361000812 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 746361000813 DNA binding residues [nucleotide binding] 746361000814 putative dimer interface [polypeptide binding]; other site 746361000815 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 746361000816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 746361000817 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 746361000818 hypothetical protein; Provisional; Region: PRK13667 746361000819 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 746361000820 Glycoprotease family; Region: Peptidase_M22; pfam00814 746361000821 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 746361000822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000823 Coenzyme A binding pocket [chemical binding]; other site 746361000824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361000825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361000826 Coenzyme A binding pocket [chemical binding]; other site 746361000827 UGMP family protein; Validated; Region: PRK09604 746361000828 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 746361000829 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 746361000830 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 746361000831 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 746361000832 Walker A/P-loop; other site 746361000833 ATP binding site [chemical binding]; other site 746361000834 Q-loop/lid; other site 746361000835 ABC transporter signature motif; other site 746361000836 Walker B; other site 746361000837 D-loop; other site 746361000838 H-loop/switch region; other site 746361000839 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 746361000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361000841 dimer interface [polypeptide binding]; other site 746361000842 conserved gate region; other site 746361000843 putative PBP binding loops; other site 746361000844 ABC-ATPase subunit interface; other site 746361000845 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 746361000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361000847 dimer interface [polypeptide binding]; other site 746361000848 conserved gate region; other site 746361000849 ABC-ATPase subunit interface; other site 746361000850 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 746361000851 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 746361000852 active site 746361000853 metal binding site [ion binding]; metal-binding site 746361000854 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 746361000855 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 746361000856 dimer interface [polypeptide binding]; other site 746361000857 catalytic triad [active] 746361000858 peroxidatic and resolving cysteines [active] 746361000859 Peptidase family M1; Region: Peptidase_M1; pfam01433 746361000860 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 746361000861 Zn binding site [ion binding]; other site 746361000862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361000863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361000864 dimer interface [polypeptide binding]; other site 746361000865 phosphorylation site [posttranslational modification] 746361000866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361000867 ATP binding site [chemical binding]; other site 746361000868 Mg2+ binding site [ion binding]; other site 746361000869 G-X-G motif; other site 746361000870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361000872 active site 746361000873 phosphorylation site [posttranslational modification] 746361000874 intermolecular recognition site; other site 746361000875 dimerization interface [polypeptide binding]; other site 746361000876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361000877 DNA binding site [nucleotide binding] 746361000878 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 746361000879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361000880 putative substrate translocation pore; other site 746361000881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361000882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361000883 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 746361000884 Cation efflux family; Region: Cation_efflux; pfam01545 746361000885 Predicted transcriptional regulators [Transcription]; Region: COG1695 746361000886 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 746361000887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361000888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361000889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361000890 Walker A/P-loop; other site 746361000891 ATP binding site [chemical binding]; other site 746361000892 Q-loop/lid; other site 746361000893 ABC transporter signature motif; other site 746361000894 Walker B; other site 746361000895 D-loop; other site 746361000896 H-loop/switch region; other site 746361000897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361000898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361000899 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 746361000900 Walker A/P-loop; other site 746361000901 ATP binding site [chemical binding]; other site 746361000902 Q-loop/lid; other site 746361000903 ABC transporter signature motif; other site 746361000904 Walker B; other site 746361000905 D-loop; other site 746361000906 H-loop/switch region; other site 746361000907 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 746361000908 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 746361000909 hinge; other site 746361000910 active site 746361000911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 746361000912 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361000913 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 746361000914 Walker A/P-loop; other site 746361000915 ATP binding site [chemical binding]; other site 746361000916 Q-loop/lid; other site 746361000917 ABC transporter signature motif; other site 746361000918 Walker B; other site 746361000919 D-loop; other site 746361000920 H-loop/switch region; other site 746361000921 H+ Antiporter protein; Region: 2A0121; TIGR00900 746361000922 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 746361000923 BioY family; Region: BioY; pfam02632 746361000924 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 746361000925 putative deacylase active site [active] 746361000926 Predicted membrane protein [Function unknown]; Region: COG3859 746361000927 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 746361000928 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 746361000929 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 746361000930 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 746361000931 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 746361000932 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 746361000933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361000934 acetoin reductases; Region: 23BDH; TIGR02415 746361000935 NAD(P) binding site [chemical binding]; other site 746361000936 active site 746361000937 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 746361000938 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 746361000939 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 746361000940 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 746361000941 Walker A/P-loop; other site 746361000942 ATP binding site [chemical binding]; other site 746361000943 Q-loop/lid; other site 746361000944 ABC transporter signature motif; other site 746361000945 Walker B; other site 746361000946 D-loop; other site 746361000947 H-loop/switch region; other site 746361000948 NIL domain; Region: NIL; pfam09383 746361000949 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 746361000950 hypothetical protein; Provisional; Region: PRK13661 746361000951 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 746361000952 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 746361000953 Walker A/P-loop; other site 746361000954 ATP binding site [chemical binding]; other site 746361000955 Q-loop/lid; other site 746361000956 ABC transporter signature motif; other site 746361000957 Walker B; other site 746361000958 D-loop; other site 746361000959 H-loop/switch region; other site 746361000960 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 746361000961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 746361000962 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 746361000963 Walker A/P-loop; other site 746361000964 ATP binding site [chemical binding]; other site 746361000965 Q-loop/lid; other site 746361000966 ABC transporter signature motif; other site 746361000967 Walker B; other site 746361000968 D-loop; other site 746361000969 H-loop/switch region; other site 746361000970 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 746361000971 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361000972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361000973 non-specific DNA binding site [nucleotide binding]; other site 746361000974 salt bridge; other site 746361000975 sequence-specific DNA binding site [nucleotide binding]; other site 746361000976 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 746361000977 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 746361000978 Walker A/P-loop; other site 746361000979 ATP binding site [chemical binding]; other site 746361000980 Q-loop/lid; other site 746361000981 ABC transporter signature motif; other site 746361000982 Walker B; other site 746361000983 D-loop; other site 746361000984 H-loop/switch region; other site 746361000985 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 746361000986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746361000987 ABC-ATPase subunit interface; other site 746361000988 dimer interface [polypeptide binding]; other site 746361000989 putative PBP binding regions; other site 746361000990 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 746361000991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746361000992 ABC-ATPase subunit interface; other site 746361000993 dimer interface [polypeptide binding]; other site 746361000994 putative PBP binding regions; other site 746361000995 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 746361000996 putative ligand binding residues [chemical binding]; other site 746361000997 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 746361000998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361000999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361001000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 746361001001 dimerization interface [polypeptide binding]; other site 746361001002 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 746361001003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361001004 putative substrate translocation pore; other site 746361001005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746361001006 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746361001007 active site 746361001008 catalytic tetrad [active] 746361001009 Predicted transcriptional regulators [Transcription]; Region: COG1733 746361001010 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 746361001011 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 746361001012 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361001013 putative metal binding site [ion binding]; other site 746361001014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361001015 catalytic core [active] 746361001016 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361001017 peroxiredoxin; Region: AhpC; TIGR03137 746361001018 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 746361001019 dimer interface [polypeptide binding]; other site 746361001020 decamer (pentamer of dimers) interface [polypeptide binding]; other site 746361001021 catalytic triad [active] 746361001022 peroxidatic and resolving cysteines [active] 746361001023 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 746361001024 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 746361001025 catalytic residue [active] 746361001026 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 746361001027 catalytic residues [active] 746361001028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361001029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361001030 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 746361001031 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 746361001032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 746361001033 recombination protein RecR; Reviewed; Region: recR; PRK00076 746361001034 RecR protein; Region: RecR; pfam02132 746361001035 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 746361001036 putative active site [active] 746361001037 putative metal-binding site [ion binding]; other site 746361001038 tetramer interface [polypeptide binding]; other site 746361001039 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 746361001040 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 746361001041 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 746361001042 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 746361001043 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746361001044 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361001045 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746361001046 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 746361001047 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 746361001048 peptide binding site [polypeptide binding]; other site 746361001049 potential frameshift: common BLAST hit: gi|116511203|ref|YP_808419.1| ABC-type oligopeptide transport system, periplasmic component 746361001050 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 746361001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361001052 dimer interface [polypeptide binding]; other site 746361001053 conserved gate region; other site 746361001054 putative PBP binding loops; other site 746361001055 ABC-ATPase subunit interface; other site 746361001056 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 746361001057 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 746361001058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361001059 dimer interface [polypeptide binding]; other site 746361001060 conserved gate region; other site 746361001061 putative PBP binding loops; other site 746361001062 ABC-ATPase subunit interface; other site 746361001063 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 746361001064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361001065 Walker A/P-loop; other site 746361001066 ATP binding site [chemical binding]; other site 746361001067 Q-loop/lid; other site 746361001068 ABC transporter signature motif; other site 746361001069 Walker B; other site 746361001070 D-loop; other site 746361001071 H-loop/switch region; other site 746361001072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746361001073 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 746361001074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361001075 Walker A/P-loop; other site 746361001076 ATP binding site [chemical binding]; other site 746361001077 Q-loop/lid; other site 746361001078 ABC transporter signature motif; other site 746361001079 Walker B; other site 746361001080 D-loop; other site 746361001081 H-loop/switch region; other site 746361001082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746361001083 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 746361001084 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 746361001085 G1 box; other site 746361001086 putative GEF interaction site [polypeptide binding]; other site 746361001087 GTP/Mg2+ binding site [chemical binding]; other site 746361001088 Switch I region; other site 746361001089 G2 box; other site 746361001090 G3 box; other site 746361001091 Switch II region; other site 746361001092 G4 box; other site 746361001093 G5 box; other site 746361001094 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 746361001095 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 746361001096 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746361001097 ATP binding site [chemical binding]; other site 746361001098 Mg++ binding site [ion binding]; other site 746361001099 motif III; other site 746361001100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361001101 nucleotide binding region [chemical binding]; other site 746361001102 ATP-binding site [chemical binding]; other site 746361001103 GTPase Era; Reviewed; Region: era; PRK00089 746361001104 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 746361001105 G1 box; other site 746361001106 GTP/Mg2+ binding site [chemical binding]; other site 746361001107 Switch I region; other site 746361001108 G2 box; other site 746361001109 Switch II region; other site 746361001110 G3 box; other site 746361001111 G4 box; other site 746361001112 G5 box; other site 746361001113 KH domain; Region: KH_2; pfam07650 746361001114 asparagine synthetase B; Provisional; Region: asnB; PRK09431 746361001115 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 746361001116 dimer interface [polypeptide binding]; other site 746361001117 active site 746361001118 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746361001119 Ligand Binding Site [chemical binding]; other site 746361001120 Molecular Tunnel; other site 746361001121 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 746361001122 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 746361001123 DNA binding site [nucleotide binding] 746361001124 catalytic residue [active] 746361001125 H2TH interface [polypeptide binding]; other site 746361001126 putative catalytic residues [active] 746361001127 turnover-facilitating residue; other site 746361001128 intercalation triad [nucleotide binding]; other site 746361001129 8OG recognition residue [nucleotide binding]; other site 746361001130 putative reading head residues; other site 746361001131 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 746361001132 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 746361001133 recombinase A; Provisional; Region: recA; PRK09354 746361001134 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 746361001135 hexamer interface [polypeptide binding]; other site 746361001136 Walker A motif; other site 746361001137 ATP binding site [chemical binding]; other site 746361001138 Walker B motif; other site 746361001139 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 746361001140 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 746361001141 Protein of unknown function (DUF964); Region: DUF964; cl01483 746361001142 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 746361001143 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 746361001144 putative active site [active] 746361001145 putative triphosphate binding site [ion binding]; other site 746361001146 putative metal binding residues [ion binding]; other site 746361001147 Protein of unknown function (DUF817); Region: DUF817; pfam05675 746361001148 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 746361001149 synthetase active site [active] 746361001150 NTP binding site [chemical binding]; other site 746361001151 metal binding site [ion binding]; metal-binding site 746361001152 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 746361001153 ATP-NAD kinase; Region: NAD_kinase; pfam01513 746361001154 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746361001155 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746361001156 active site 746361001157 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746361001158 active site 746361001159 lysine transporter; Provisional; Region: PRK10836 746361001160 Predicted flavoprotein [General function prediction only]; Region: COG0431 746361001161 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 746361001162 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 746361001163 ApbE family; Region: ApbE; pfam02424 746361001164 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 746361001165 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 746361001166 dimer interface [polypeptide binding]; other site 746361001167 putative anticodon binding site; other site 746361001168 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 746361001169 motif 1; other site 746361001170 active site 746361001171 motif 2; other site 746361001172 motif 3; other site 746361001173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361001174 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 746361001175 LysR substrate binding domain; Region: LysR_substrate; pfam03466 746361001176 dimerization interface [polypeptide binding]; other site 746361001177 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 746361001178 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 746361001179 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 746361001180 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361001181 NAD binding site [chemical binding]; other site 746361001182 dimer interface [polypeptide binding]; other site 746361001183 substrate binding site [chemical binding]; other site 746361001184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361001185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361001186 LysR substrate binding domain; Region: LysR_substrate; pfam03466 746361001187 dimerization interface [polypeptide binding]; other site 746361001188 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 746361001189 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 746361001190 gating phenylalanine in ion channel; other site 746361001191 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 746361001192 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 746361001193 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 746361001194 Ligand Binding Site [chemical binding]; other site 746361001195 potential frameshift: common BLAST hit: gi|15672362|ref|NP_266536.1| efflux pump antibiotic resistance protein 746361001196 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 746361001197 OsmC-like protein; Region: OsmC; cl00767 746361001198 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 746361001199 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 746361001200 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 746361001201 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 746361001202 active site 746361001203 HIGH motif; other site 746361001204 dimer interface [polypeptide binding]; other site 746361001205 KMSKS motif; other site 746361001206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361001207 RNA binding surface [nucleotide binding]; other site 746361001208 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 746361001209 Transglycosylase; Region: Transgly; pfam00912 746361001210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 746361001211 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 746361001212 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 746361001213 oligomer interface [polypeptide binding]; other site 746361001214 active site 746361001215 metal binding site [ion binding]; metal-binding site 746361001216 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746361001217 catalytic residues [active] 746361001218 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 746361001219 putative tRNA-binding site [nucleotide binding]; other site 746361001220 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 746361001221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361001222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361001223 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361001224 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 746361001225 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 746361001226 dimer interface [polypeptide binding]; other site 746361001227 ssDNA binding site [nucleotide binding]; other site 746361001228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361001229 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 746361001230 oligomerisation interface [polypeptide binding]; other site 746361001231 mobile loop; other site 746361001232 roof hairpin; other site 746361001233 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 746361001234 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 746361001235 ring oligomerisation interface [polypeptide binding]; other site 746361001236 ATP/Mg binding site [chemical binding]; other site 746361001237 stacking interactions; other site 746361001238 hinge regions; other site 746361001239 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 746361001240 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 746361001241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 746361001242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746361001243 putative active site [active] 746361001244 heme pocket [chemical binding]; other site 746361001245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361001246 dimer interface [polypeptide binding]; other site 746361001247 phosphorylation site [posttranslational modification] 746361001248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361001249 ATP binding site [chemical binding]; other site 746361001250 Mg2+ binding site [ion binding]; other site 746361001251 G-X-G motif; other site 746361001252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361001253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361001254 active site 746361001255 phosphorylation site [posttranslational modification] 746361001256 intermolecular recognition site; other site 746361001257 dimerization interface [polypeptide binding]; other site 746361001258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361001259 DNA binding site [nucleotide binding] 746361001260 thymidylate kinase; Validated; Region: tmk; PRK00698 746361001261 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 746361001262 TMP-binding site; other site 746361001263 ATP-binding site [chemical binding]; other site 746361001264 DNA polymerase III subunit delta'; Validated; Region: PRK07276 746361001265 DNA polymerase III subunit delta'; Validated; Region: PRK08485 746361001266 PSP1 C-terminal conserved region; Region: PSP1; cl00770 746361001267 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 746361001268 Predicted methyltransferases [General function prediction only]; Region: COG0313 746361001269 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 746361001270 putative SAM binding site [chemical binding]; other site 746361001271 putative homodimer interface [polypeptide binding]; other site 746361001272 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 746361001273 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 746361001274 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 746361001275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361001276 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 746361001277 Walker A/P-loop; other site 746361001278 ATP binding site [chemical binding]; other site 746361001279 Q-loop/lid; other site 746361001280 ABC transporter signature motif; other site 746361001281 Walker B; other site 746361001282 D-loop; other site 746361001283 H-loop/switch region; other site 746361001284 MarR family; Region: MarR_2; pfam12802 746361001285 mevalonate kinase; Region: mevalon_kin; TIGR00549 746361001286 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 746361001287 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 746361001288 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 746361001289 diphosphomevalonate decarboxylase; Region: PLN02407 746361001290 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 746361001291 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 746361001292 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 746361001293 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 746361001294 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 746361001295 homotetramer interface [polypeptide binding]; other site 746361001296 FMN binding site [chemical binding]; other site 746361001297 homodimer contacts [polypeptide binding]; other site 746361001298 putative active site [active] 746361001299 putative substrate binding site [chemical binding]; other site 746361001300 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 746361001301 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 746361001302 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 746361001303 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 746361001304 Carbon starvation protein CstA; Region: CstA; pfam02554 746361001305 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 746361001306 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 746361001307 Predicted transcriptional regulator [Transcription]; Region: COG2378 746361001308 HTH domain; Region: HTH_11; pfam08279 746361001309 WYL domain; Region: WYL; pfam13280 746361001310 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746361001311 DEAD-like helicases superfamily; Region: DEXDc; smart00487 746361001312 ATP binding site [chemical binding]; other site 746361001313 Mg++ binding site [ion binding]; other site 746361001314 motif III; other site 746361001315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361001316 nucleotide binding region [chemical binding]; other site 746361001317 ATP-binding site [chemical binding]; other site 746361001318 Uncharacterized conserved protein [Function unknown]; Region: COG1434 746361001319 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 746361001320 putative active site [active] 746361001321 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361001322 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361001323 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361001324 putative active site [active] 746361001325 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 746361001326 active site 746361001327 P-loop; other site 746361001328 phosphorylation site [posttranslational modification] 746361001329 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 746361001330 active site 746361001331 methionine cluster; other site 746361001332 phosphorylation site [posttranslational modification] 746361001333 metal binding site [ion binding]; metal-binding site 746361001334 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361001335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361001336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361001337 putative active site [active] 746361001338 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 746361001339 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 746361001340 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 746361001341 beta-galactosidase; Region: BGL; TIGR03356 746361001342 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 746361001343 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 746361001344 nucleotide binding pocket [chemical binding]; other site 746361001345 K-X-D-G motif; other site 746361001346 catalytic site [active] 746361001347 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 746361001348 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 746361001349 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 746361001350 Dimer interface [polypeptide binding]; other site 746361001351 BRCT sequence motif; other site 746361001352 putative lipid kinase; Reviewed; Region: PRK13055 746361001353 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 746361001354 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 746361001355 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 746361001356 Walker A/P-loop; other site 746361001357 ATP binding site [chemical binding]; other site 746361001358 Q-loop/lid; other site 746361001359 ABC transporter signature motif; other site 746361001360 Walker B; other site 746361001361 D-loop; other site 746361001362 H-loop/switch region; other site 746361001363 TOBE domain; Region: TOBE_2; pfam08402 746361001364 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 746361001365 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 746361001366 dimer interface [polypeptide binding]; other site 746361001367 PYR/PP interface [polypeptide binding]; other site 746361001368 TPP binding site [chemical binding]; other site 746361001369 substrate binding site [chemical binding]; other site 746361001370 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 746361001371 Domain of unknown function; Region: EKR; smart00890 746361001372 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 746361001373 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 746361001374 TPP-binding site [chemical binding]; other site 746361001375 dimer interface [polypeptide binding]; other site 746361001376 Uncharacterized conserved protein [Function unknown]; Region: COG1624 746361001377 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 746361001378 potential frameshift: common BLAST hit: gi|222153231|ref|YP_002562408.1| exported protein 746361001379 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 746361001380 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 746361001381 active site 746361001382 substrate binding site [chemical binding]; other site 746361001383 metal binding site [ion binding]; metal-binding site 746361001384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 746361001385 DNA-binding site [nucleotide binding]; DNA binding site 746361001386 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 746361001387 UTRA domain; Region: UTRA; pfam07702 746361001388 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 746361001389 HPr interaction site; other site 746361001390 glycerol kinase (GK) interaction site [polypeptide binding]; other site 746361001391 active site 746361001392 phosphorylation site [posttranslational modification] 746361001393 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 746361001394 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 746361001395 active site turn [active] 746361001396 phosphorylation site [posttranslational modification] 746361001397 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 746361001398 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 746361001399 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 746361001400 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 746361001401 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 746361001402 beta-phosphoglucomutase; Region: bPGM; TIGR01990 746361001403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361001404 motif II; other site 746361001405 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746361001406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746361001407 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 746361001408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 746361001409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361001410 Coenzyme A binding pocket [chemical binding]; other site 746361001411 Transcriptional regulator [Transcription]; Region: LytR; COG1316 746361001412 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 746361001413 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 746361001414 dimerization interface 3.5A [polypeptide binding]; other site 746361001415 active site 746361001416 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 746361001417 dimer interface [polypeptide binding]; other site 746361001418 substrate binding site [chemical binding]; other site 746361001419 ATP binding site [chemical binding]; other site 746361001420 Predicted membrane protein [Function unknown]; Region: COG4720 746361001421 hypothetical protein; Provisional; Region: PRK13690 746361001422 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 746361001423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746361001424 catalytic residue [active] 746361001425 CTP synthetase; Validated; Region: pyrG; PRK05380 746361001426 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 746361001427 Catalytic site [active] 746361001428 active site 746361001429 UTP binding site [chemical binding]; other site 746361001430 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 746361001431 active site 746361001432 putative oxyanion hole; other site 746361001433 catalytic triad [active] 746361001434 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 746361001435 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 746361001436 NAD(P) binding site [chemical binding]; other site 746361001437 LDH/MDH dimer interface [polypeptide binding]; other site 746361001438 substrate binding site [chemical binding]; other site 746361001439 Predicted membrane protein [Function unknown]; Region: COG4420 746361001440 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 746361001441 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 746361001442 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 746361001443 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 746361001444 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 746361001445 Substrate-binding site [chemical binding]; other site 746361001446 Substrate specificity [chemical binding]; other site 746361001447 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 746361001448 putative active site [active] 746361001449 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 746361001450 putative active site [active] 746361001451 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 746361001452 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 746361001453 active site 746361001454 PHP Thumb interface [polypeptide binding]; other site 746361001455 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 746361001456 generic binding surface II; other site 746361001457 generic binding surface I; other site 746361001458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361001459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361001460 DNA binding site [nucleotide binding] 746361001461 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 746361001462 dimerization interface [polypeptide binding]; other site 746361001463 ligand binding site [chemical binding]; other site 746361001464 RDD family; Region: RDD; pfam06271 746361001465 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 746361001466 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 746361001467 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 746361001468 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 746361001469 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 746361001470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361001471 dimer interface [polypeptide binding]; other site 746361001472 conserved gate region; other site 746361001473 putative PBP binding loops; other site 746361001474 ABC-ATPase subunit interface; other site 746361001475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 746361001476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361001477 dimer interface [polypeptide binding]; other site 746361001478 conserved gate region; other site 746361001479 putative PBP binding loops; other site 746361001480 ABC-ATPase subunit interface; other site 746361001481 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 746361001482 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 746361001483 EDD domain protein, DegV family; Region: DegV; TIGR00762 746361001484 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 746361001485 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 746361001486 active site 746361001487 catalytic triad [active] 746361001488 oxyanion hole [active] 746361001489 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 746361001490 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 746361001491 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 746361001492 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 746361001493 IHF dimer interface [polypeptide binding]; other site 746361001494 IHF - DNA interface [nucleotide binding]; other site 746361001495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 746361001496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361001497 Coenzyme A binding pocket [chemical binding]; other site 746361001498 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 746361001499 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 746361001500 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 746361001501 DNA binding site [nucleotide binding] 746361001502 active site 746361001503 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 746361001504 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 746361001505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361001506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361001507 N-acetyltransferase; Region: Acetyltransf_2; cl00949 746361001508 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 746361001509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746361001510 Walker A/P-loop; other site 746361001511 ATP binding site [chemical binding]; other site 746361001512 Q-loop/lid; other site 746361001513 ABC transporter signature motif; other site 746361001514 Walker B; other site 746361001515 D-loop; other site 746361001516 H-loop/switch region; other site 746361001517 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 746361001518 ABC-2 type transporter; Region: ABC2_membrane; cl17235 746361001519 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746361001520 LytTr DNA-binding domain; Region: LytTR; pfam04397 746361001521 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 746361001522 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 746361001523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746361001524 catalytic residue [active] 746361001525 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 746361001526 NlpC/P60 family; Region: NLPC_P60; cl17555 746361001527 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 746361001528 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 746361001529 peptide binding site [polypeptide binding]; other site 746361001530 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 746361001531 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 746361001532 dimer interface [polypeptide binding]; other site 746361001533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361001534 catalytic residue [active] 746361001535 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 746361001536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361001537 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361001538 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361001539 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 746361001540 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 746361001541 Transglycosylase; Region: Transgly; pfam00912 746361001542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 746361001543 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 746361001544 hypothetical protein; Provisional; Region: PRK13660 746361001545 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 746361001546 ArsC family; Region: ArsC; pfam03960 746361001547 putative catalytic residues [active] 746361001548 thiol/disulfide switch; other site 746361001549 hypothetical protein; Provisional; Region: PRK04387 746361001550 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 746361001551 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 746361001552 active site 746361001553 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 746361001554 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 746361001555 hinge; other site 746361001556 active site 746361001557 trigger factor; Provisional; Region: tig; PRK01490 746361001558 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 746361001559 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 746361001560 potential protein location (hypothetical protein LLNZ_02685 [Lactococcus lactis subsp. cremoris NZ9000]) that overlaps RNA (tRNA-G) 746361001561 DNA primase, catalytic core; Region: dnaG; TIGR01391 746361001562 CHC2 zinc finger; Region: zf-CHC2; pfam01807 746361001563 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 746361001564 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 746361001565 active site 746361001566 metal binding site [ion binding]; metal-binding site 746361001567 interdomain interaction site; other site 746361001568 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 746361001569 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 746361001570 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 746361001571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746361001572 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 746361001573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746361001574 DNA binding residues [nucleotide binding] 746361001575 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361001576 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361001577 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361001578 putative active site [active] 746361001579 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 746361001580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361001581 putative substrate translocation pore; other site 746361001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361001583 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 746361001584 Double zinc ribbon; Region: DZR; pfam12773 746361001585 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 746361001586 Double zinc ribbon; Region: DZR; pfam12773 746361001587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361001588 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361001589 Walker A motif; other site 746361001590 ATP binding site [chemical binding]; other site 746361001591 Walker B motif; other site 746361001592 arginine finger; other site 746361001593 UvrB/uvrC motif; Region: UVR; pfam02151 746361001594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361001595 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361001596 Walker A motif; other site 746361001597 ATP binding site [chemical binding]; other site 746361001598 Walker B motif; other site 746361001599 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 746361001600 Predicted transcriptional regulator [Transcription]; Region: COG1959 746361001601 Transcriptional regulator; Region: Rrf2; pfam02082 746361001602 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 746361001603 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 746361001604 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 746361001605 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 746361001606 active site 746361001607 catalytic residues [active] 746361001608 metal binding site [ion binding]; metal-binding site 746361001609 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 746361001610 putative active site [active] 746361001611 Ap4A binding site [chemical binding]; other site 746361001612 nudix motif; other site 746361001613 putative metal binding site [ion binding]; other site 746361001614 excinuclease ABC subunit B; Provisional; Region: PRK05298 746361001615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361001616 ATP binding site [chemical binding]; other site 746361001617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361001618 nucleotide binding region [chemical binding]; other site 746361001619 ATP-binding site [chemical binding]; other site 746361001620 Ultra-violet resistance protein B; Region: UvrB; pfam12344 746361001621 UvrB/uvrC motif; Region: UVR; pfam02151 746361001622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746361001623 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 746361001624 substrate binding pocket [chemical binding]; other site 746361001625 membrane-bound complex binding site; other site 746361001626 hinge residues; other site 746361001627 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 746361001628 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 746361001629 metal binding site [ion binding]; metal-binding site 746361001630 dimer interface [polypeptide binding]; other site 746361001631 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 746361001632 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 746361001633 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 746361001634 NAD binding site [chemical binding]; other site 746361001635 homotetramer interface [polypeptide binding]; other site 746361001636 homodimer interface [polypeptide binding]; other site 746361001637 substrate binding site [chemical binding]; other site 746361001638 active site 746361001639 OxaA-like protein precursor; Provisional; Region: PRK02463 746361001640 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 746361001641 Eukaryotic phosphomannomutase; Region: PMM; cl17107 746361001642 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 746361001643 Predicted membrane protein [Function unknown]; Region: COG4684 746361001644 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 746361001645 Flavoprotein; Region: Flavoprotein; pfam02441 746361001646 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 746361001647 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 746361001648 active site 1 [active] 746361001649 dimer interface [polypeptide binding]; other site 746361001650 hexamer interface [polypeptide binding]; other site 746361001651 active site 2 [active] 746361001652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361001653 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 746361001654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361001655 motif II; other site 746361001656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361001657 putative transposase OrfB; Reviewed; Region: PHA02517 746361001658 HTH-like domain; Region: HTH_21; pfam13276 746361001659 Integrase core domain; Region: rve; pfam00665 746361001660 Integrase core domain; Region: rve_3; pfam13683 746361001661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001662 Transposase; Region: HTH_Tnp_1; pfam01527 746361001663 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 746361001664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361001665 active site 746361001666 Uncharacterized conserved protein [Function unknown]; Region: COG1359 746361001667 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361001668 MULE transposase domain; Region: MULE; pfam10551 746361001669 thymidine kinase; Provisional; Region: PRK04296 746361001670 peptide chain release factor 1; Validated; Region: prfA; PRK00591 746361001671 This domain is found in peptide chain release factors; Region: PCRF; smart00937 746361001672 RF-1 domain; Region: RF-1; pfam00472 746361001673 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 746361001674 dimer interface [polypeptide binding]; other site 746361001675 FMN binding site [chemical binding]; other site 746361001676 NADPH bind site [chemical binding]; other site 746361001677 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 746361001678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361001679 S-adenosylmethionine binding site [chemical binding]; other site 746361001680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361001681 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 746361001682 Coenzyme A binding pocket [chemical binding]; other site 746361001683 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 746361001684 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 746361001685 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 746361001686 dimer interface [polypeptide binding]; other site 746361001687 active site 746361001688 glycine-pyridoxal phosphate binding site [chemical binding]; other site 746361001689 folate binding site [chemical binding]; other site 746361001690 Lysozyme-like; Region: Lysozyme_like; pfam13702 746361001691 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 746361001692 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 746361001693 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746361001694 catalytic residue [active] 746361001695 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 746361001696 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 746361001697 putative ligand binding site [chemical binding]; other site 746361001698 putative NAD binding site [chemical binding]; other site 746361001699 putative catalytic site [active] 746361001700 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 746361001701 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361001702 phosphoserine phosphatase SerB; Region: serB; TIGR00338 746361001703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361001704 motif II; other site 746361001705 acylphosphatase; Provisional; Region: PRK14434 746361001706 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 746361001707 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 746361001708 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746361001709 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 746361001710 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361001711 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 746361001712 DNA binding residues [nucleotide binding] 746361001713 putative dimer interface [polypeptide binding]; other site 746361001714 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 746361001715 dimer interface [polypeptide binding]; other site 746361001716 flavodoxin; Validated; Region: PRK07308 746361001717 potential frameshift: common BLAST hit: gi|15672591|ref|NP_266765.1| membrane-bound transport protein 746361001718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361001719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361001720 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 746361001721 active site 746361001722 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 746361001723 Predicted membrane protein [Function unknown]; Region: COG2246 746361001724 GtrA-like protein; Region: GtrA; pfam04138 746361001725 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 746361001726 HPr kinase/phosphorylase; Provisional; Region: PRK05428 746361001727 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 746361001728 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 746361001729 Hpr binding site; other site 746361001730 active site 746361001731 homohexamer subunit interaction site [polypeptide binding]; other site 746361001732 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 746361001733 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 746361001734 YtxH-like protein; Region: YtxH; cl02079 746361001735 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 746361001736 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 746361001737 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 746361001738 potential frameshift: common BLAST hit: gi|116511416|ref|YP_808632.1| K+ transporter 746361001739 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 746361001740 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 746361001741 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746361001742 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 746361001743 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 746361001744 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 746361001745 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 746361001746 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 746361001747 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 746361001748 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 746361001749 Int/Topo IB signature motif; other site 746361001750 potential frameshift: common BLAST hit: gi|15673413|ref|NP_267587.1| prophage pi3 protein 58 746361001751 conserved hypothetical integral membrane protein; Region: TIGR03766 746361001752 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 746361001753 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 746361001754 Ligand binding site; other site 746361001755 Putative Catalytic site; other site 746361001756 DXD motif; other site 746361001757 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 746361001758 pentamer interface [polypeptide binding]; other site 746361001759 dodecaamer interface [polypeptide binding]; other site 746361001760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361001761 non-specific DNA binding site [nucleotide binding]; other site 746361001762 salt bridge; other site 746361001763 sequence-specific DNA binding site [nucleotide binding]; other site 746361001764 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 746361001765 ribonuclease Z; Region: RNase_Z; TIGR02651 746361001766 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 746361001767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361001768 NAD(P) binding site [chemical binding]; other site 746361001769 active site 746361001770 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 746361001771 DHH family; Region: DHH; pfam01368 746361001772 DHHA1 domain; Region: DHHA1; pfam02272 746361001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 746361001774 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361001775 active site 746361001776 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 746361001777 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 746361001778 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 746361001779 dimerization interface [polypeptide binding]; other site 746361001780 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 746361001781 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 746361001782 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 746361001783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001784 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361001785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001786 Homeodomain-like domain; Region: HTH_23; cl17451 746361001787 Integrase core domain; Region: rve; pfam00665 746361001788 Integrase core domain; Region: rve_2; pfam13333 746361001789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001790 Transposase; Region: HTH_Tnp_1; pfam01527 746361001791 putative transposase OrfB; Reviewed; Region: PHA02517 746361001792 HTH-like domain; Region: HTH_21; pfam13276 746361001793 Integrase core domain; Region: rve; pfam00665 746361001794 Integrase core domain; Region: rve_3; pfam13683 746361001795 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 746361001796 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 746361001797 Clp amino terminal domain; Region: Clp_N; pfam02861 746361001798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361001799 Walker A motif; other site 746361001800 ATP binding site [chemical binding]; other site 746361001801 Walker B motif; other site 746361001802 arginine finger; other site 746361001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361001804 Walker A motif; other site 746361001805 ATP binding site [chemical binding]; other site 746361001806 Walker B motif; other site 746361001807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 746361001808 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 746361001809 30S subunit binding site; other site 746361001810 enolase; Provisional; Region: eno; PRK00077 746361001811 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 746361001812 dimer interface [polypeptide binding]; other site 746361001813 metal binding site [ion binding]; metal-binding site 746361001814 substrate binding pocket [chemical binding]; other site 746361001815 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361001816 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 746361001817 active site 746361001818 DNA binding site [nucleotide binding] 746361001819 Int/Topo IB signature motif; other site 746361001820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361001821 Integrase core domain; Region: rve; pfam00665 746361001822 Integrase core domain; Region: rve_3; pfam13683 746361001823 Transposase; Region: HTH_Tnp_1; pfam01527 746361001824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001825 putative transposase OrfB; Reviewed; Region: PHA02517 746361001826 HTH-like domain; Region: HTH_21; pfam13276 746361001827 Integrase core domain; Region: rve; pfam00665 746361001828 Integrase core domain; Region: rve_3; pfam13683 746361001829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001830 Transposase; Region: HTH_Tnp_1; pfam01527 746361001831 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 746361001832 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361001833 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361001834 Walker A/P-loop; other site 746361001835 ATP binding site [chemical binding]; other site 746361001836 Q-loop/lid; other site 746361001837 ABC transporter signature motif; other site 746361001838 Walker B; other site 746361001839 D-loop; other site 746361001840 H-loop/switch region; other site 746361001841 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746361001842 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 746361001843 FtsX-like permease family; Region: FtsX; pfam02687 746361001844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361001845 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 746361001846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746361001847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746361001848 acyl-activating enzyme (AAE) consensus motif; other site 746361001849 acyl-activating enzyme (AAE) consensus motif; other site 746361001850 AMP binding site [chemical binding]; other site 746361001851 active site 746361001852 CoA binding site [chemical binding]; other site 746361001853 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 746361001854 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 746361001855 Cl binding site [ion binding]; other site 746361001856 oligomer interface [polypeptide binding]; other site 746361001857 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 746361001858 Pyruvate formate lyase 1; Region: PFL1; cd01678 746361001859 coenzyme A binding site [chemical binding]; other site 746361001860 active site 746361001861 catalytic residues [active] 746361001862 glycine loop; other site 746361001863 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 746361001864 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 746361001865 CoA-binding site [chemical binding]; other site 746361001866 ATP-binding [chemical binding]; other site 746361001867 drug efflux system protein MdtG; Provisional; Region: PRK09874 746361001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361001869 putative substrate translocation pore; other site 746361001870 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 746361001871 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 746361001872 pyruvate carboxylase; Reviewed; Region: PRK12999 746361001873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746361001874 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 746361001875 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 746361001876 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 746361001877 active site 746361001878 catalytic residues [active] 746361001879 metal binding site [ion binding]; metal-binding site 746361001880 homodimer binding site [polypeptide binding]; other site 746361001881 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 746361001882 carboxyltransferase (CT) interaction site; other site 746361001883 biotinylation site [posttranslational modification]; other site 746361001884 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 746361001885 dimer interface [polypeptide binding]; other site 746361001886 Citrate synthase; Region: Citrate_synt; pfam00285 746361001887 active site 746361001888 citrylCoA binding site [chemical binding]; other site 746361001889 oxalacetate/citrate binding site [chemical binding]; other site 746361001890 coenzyme A binding site [chemical binding]; other site 746361001891 catalytic triad [active] 746361001892 aconitate hydratase; Validated; Region: PRK09277 746361001893 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 746361001894 substrate binding site [chemical binding]; other site 746361001895 ligand binding site [chemical binding]; other site 746361001896 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 746361001897 substrate binding site [chemical binding]; other site 746361001898 Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538 746361001899 isocitrate dehydrogenase; Validated; Region: PRK07362 746361001900 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 746361001901 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 746361001902 oligomer interface [polypeptide binding]; other site 746361001903 active site residues [active] 746361001904 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 746361001905 ArsC family; Region: ArsC; pfam03960 746361001906 putative catalytic residues [active] 746361001907 thiol/disulfide switch; other site 746361001908 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 746361001909 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 746361001910 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361001911 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 746361001912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361001913 motif II; other site 746361001914 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 746361001915 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 746361001916 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 746361001917 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 746361001918 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 746361001919 DXD motif; other site 746361001920 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 746361001921 putative transposase OrfB; Reviewed; Region: PHA02517 746361001922 HTH-like domain; Region: HTH_21; pfam13276 746361001923 Integrase core domain; Region: rve; pfam00665 746361001924 Integrase core domain; Region: rve_3; pfam13683 746361001925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001926 Transposase; Region: HTH_Tnp_1; pfam01527 746361001927 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 746361001928 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 746361001929 Predicted acetyltransferase [General function prediction only]; Region: COG2388 746361001930 putative transposase OrfB; Reviewed; Region: PHA02517 746361001931 HTH-like domain; Region: HTH_21; pfam13276 746361001932 Integrase core domain; Region: rve; pfam00665 746361001933 Integrase core domain; Region: rve_3; pfam13683 746361001934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001935 Transposase; Region: HTH_Tnp_1; pfam01527 746361001936 Integrase core domain; Region: rve; pfam00665 746361001937 Transposase; Region: HTH_Tnp_1; pfam01527 746361001938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001939 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 746361001940 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 746361001941 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 746361001942 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 746361001943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361001944 ATP binding site [chemical binding]; other site 746361001945 putative Mg++ binding site [ion binding]; other site 746361001946 HsdM N-terminal domain; Region: HsdM_N; pfam12161 746361001947 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 746361001948 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746361001949 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746361001950 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 746361001951 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746361001952 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 746361001953 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 746361001954 Cl binding site [ion binding]; other site 746361001955 oligomer interface [polypeptide binding]; other site 746361001956 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361001957 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361001958 MULE transposase domain; Region: MULE; pfam10551 746361001959 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 746361001960 putative substrate binding pocket [chemical binding]; other site 746361001961 AC domain interface; other site 746361001962 catalytic triad [active] 746361001963 AB domain interface; other site 746361001964 interchain disulfide; other site 746361001965 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 746361001966 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 746361001967 metal binding site [ion binding]; metal-binding site 746361001968 dimer interface [polypeptide binding]; other site 746361001969 potential frameshift: common BLAST hit: gi|116511743|ref|YP_808959.1| transposase 746361001970 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 746361001971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361001972 putative substrate translocation pore; other site 746361001973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361001974 Coenzyme A binding pocket [chemical binding]; other site 746361001975 Lactococcin-like family; Region: Lactococcin; pfam04369 746361001976 Plasmid replication protein; Region: Rep_2; pfam01719 746361001977 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 746361001978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 746361001979 Integrase core domain; Region: rve; pfam00665 746361001980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361001981 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 746361001982 Coenzyme A binding pocket [chemical binding]; other site 746361001983 Integrase core domain; Region: rve; pfam00665 746361001984 Integrase core domain; Region: rve_3; pfam13683 746361001985 HTH-like domain; Region: HTH_21; pfam13276 746361001986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361001987 Transposase; Region: HTH_Tnp_1; pfam01527 746361001988 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361001989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361001990 non-specific DNA binding site [nucleotide binding]; other site 746361001991 salt bridge; other site 746361001992 sequence-specific DNA binding site [nucleotide binding]; other site 746361001993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361001994 Integrase core domain; Region: rve; pfam00665 746361001995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361001996 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361001997 Walker A motif; other site 746361001998 ATP binding site [chemical binding]; other site 746361001999 Walker B motif; other site 746361002000 arginine finger; other site 746361002001 putative transposase OrfB; Reviewed; Region: PHA02517 746361002002 HTH-like domain; Region: HTH_21; pfam13276 746361002003 Integrase core domain; Region: rve; pfam00665 746361002004 Integrase core domain; Region: rve_3; pfam13683 746361002005 Lactococcin-like family; Region: Lactococcin; pfam04369 746361002006 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 746361002007 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361002008 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746361002009 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 746361002010 metal-binding site [ion binding] 746361002011 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 746361002012 dinuclear metal binding motif [ion binding]; other site 746361002013 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746361002014 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 746361002015 ligand binding site [chemical binding]; other site 746361002016 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 746361002017 putative switch regulator; other site 746361002018 non-specific DNA interactions [nucleotide binding]; other site 746361002019 DNA binding site [nucleotide binding] 746361002020 sequence specific DNA binding site [nucleotide binding]; other site 746361002021 putative cAMP binding site [chemical binding]; other site 746361002022 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 746361002023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361002024 Walker A/P-loop; other site 746361002025 ATP binding site [chemical binding]; other site 746361002026 Q-loop/lid; other site 746361002027 ABC transporter signature motif; other site 746361002028 Walker B; other site 746361002029 D-loop; other site 746361002030 H-loop/switch region; other site 746361002031 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746361002032 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361002033 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 746361002034 Walker A/P-loop; other site 746361002035 ATP binding site [chemical binding]; other site 746361002036 Q-loop/lid; other site 746361002037 ABC transporter signature motif; other site 746361002038 Walker B; other site 746361002039 D-loop; other site 746361002040 H-loop/switch region; other site 746361002041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 746361002042 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 746361002043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002044 dimer interface [polypeptide binding]; other site 746361002045 conserved gate region; other site 746361002046 putative PBP binding loops; other site 746361002047 ABC-ATPase subunit interface; other site 746361002048 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 746361002049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 746361002050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002051 dimer interface [polypeptide binding]; other site 746361002052 conserved gate region; other site 746361002053 putative PBP binding loops; other site 746361002054 ABC-ATPase subunit interface; other site 746361002055 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 746361002056 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 746361002057 peptide binding site [polypeptide binding]; other site 746361002058 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 746361002059 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 746361002060 active site 746361002061 Zn binding site [ion binding]; other site 746361002062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 746361002063 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 746361002064 Lactococcin-like family; Region: Lactococcin; pfam04369 746361002065 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361002066 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361002067 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 746361002068 Predicted transcriptional regulators [Transcription]; Region: COG1695 746361002069 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 746361002070 hypothetical protein; Validated; Region: PRK07668 746361002071 multiple promoter invertase; Provisional; Region: mpi; PRK13413 746361002072 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 746361002073 catalytic residues [active] 746361002074 catalytic nucleophile [active] 746361002075 Presynaptic Site I dimer interface [polypeptide binding]; other site 746361002076 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 746361002077 Synaptic Flat tetramer interface [polypeptide binding]; other site 746361002078 Synaptic Site I dimer interface [polypeptide binding]; other site 746361002079 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 746361002080 DNA-binding interface [nucleotide binding]; DNA binding site 746361002081 putative transposase OrfB; Reviewed; Region: PHA02517 746361002082 HTH-like domain; Region: HTH_21; pfam13276 746361002083 Integrase core domain; Region: rve; pfam00665 746361002084 Integrase core domain; Region: rve_3; pfam13683 746361002085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 746361002086 Integrase core domain; Region: rve; pfam00665 746361002087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361002088 Integrase core domain; Region: rve; pfam00665 746361002089 ThiF family; Region: ThiF; pfam00899 746361002090 ATP binding site [chemical binding]; other site 746361002091 substrate interface [chemical binding]; other site 746361002092 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 746361002093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002094 Transposase; Region: HTH_Tnp_1; pfam01527 746361002095 putative transposase OrfB; Reviewed; Region: PHA02517 746361002096 HTH-like domain; Region: HTH_21; pfam13276 746361002097 Integrase core domain; Region: rve; pfam00665 746361002098 Integrase core domain; Region: rve_3; pfam13683 746361002099 seryl-tRNA synthetase; Provisional; Region: PRK05431 746361002100 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 746361002101 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 746361002102 dimer interface [polypeptide binding]; other site 746361002103 active site 746361002104 motif 1; other site 746361002105 motif 2; other site 746361002106 motif 3; other site 746361002107 Domain of unknown function (DUF956); Region: DUF956; cl01917 746361002108 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746361002109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 746361002111 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 746361002112 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 746361002113 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 746361002114 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 746361002115 active pocket/dimerization site; other site 746361002116 active site 746361002117 phosphorylation site [posttranslational modification] 746361002118 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 746361002119 active site 746361002120 phosphorylation site [posttranslational modification] 746361002121 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 746361002122 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 746361002123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361002124 cytidylate kinase; Provisional; Region: cmk; PRK00023 746361002125 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 746361002126 CMP-binding site; other site 746361002127 The sites determining sugar specificity; other site 746361002128 Transcriptional regulator [Transcription]; Region: LytR; COG1316 746361002129 Isochorismatase family; Region: Isochorismatase; pfam00857 746361002130 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 746361002131 catalytic triad [active] 746361002132 dimer interface [polypeptide binding]; other site 746361002133 conserved cis-peptide bond; other site 746361002134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361002135 Integrase core domain; Region: rve; pfam00665 746361002136 Integrase core domain; Region: rve_3; pfam13683 746361002137 Transposase; Region: HTH_Tnp_1; pfam01527 746361002138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002139 CAAX protease self-immunity; Region: Abi; pfam02517 746361002140 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 746361002141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002142 dimer interface [polypeptide binding]; other site 746361002143 conserved gate region; other site 746361002144 putative PBP binding loops; other site 746361002145 ABC-ATPase subunit interface; other site 746361002146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002147 dimer interface [polypeptide binding]; other site 746361002148 conserved gate region; other site 746361002149 putative PBP binding loops; other site 746361002150 ABC-ATPase subunit interface; other site 746361002151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 746361002152 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 746361002153 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 746361002154 homodimer interface [polypeptide binding]; other site 746361002155 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 746361002156 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 746361002157 active site 746361002158 homodimer interface [polypeptide binding]; other site 746361002159 catalytic site [active] 746361002160 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 746361002161 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 746361002162 Ca binding site [ion binding]; other site 746361002163 active site 746361002164 catalytic site [active] 746361002165 maltose O-acetyltransferase; Provisional; Region: PRK10092 746361002166 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 746361002167 active site 746361002168 substrate binding site [chemical binding]; other site 746361002169 trimer interface [polypeptide binding]; other site 746361002170 CoA binding site [chemical binding]; other site 746361002171 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 746361002172 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 746361002173 Ca binding site [ion binding]; other site 746361002174 active site 746361002175 catalytic site [active] 746361002176 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 746361002177 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 746361002178 Ca binding site [ion binding]; other site 746361002179 active site 746361002180 catalytic site [active] 746361002181 maltose phosphorylase; Provisional; Region: PRK13807 746361002182 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 746361002183 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 746361002184 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 746361002185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361002186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361002187 DNA binding site [nucleotide binding] 746361002188 domain linker motif; other site 746361002189 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 746361002190 putative dimerization interface [polypeptide binding]; other site 746361002191 putative ligand binding site [chemical binding]; other site 746361002192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361002193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361002194 active site 746361002195 phosphorylation site [posttranslational modification] 746361002196 intermolecular recognition site; other site 746361002197 dimerization interface [polypeptide binding]; other site 746361002198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361002199 DNA binding site [nucleotide binding] 746361002200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361002201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361002202 dimer interface [polypeptide binding]; other site 746361002203 phosphorylation site [posttranslational modification] 746361002204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361002205 ATP binding site [chemical binding]; other site 746361002206 Mg2+ binding site [ion binding]; other site 746361002207 G-X-G motif; other site 746361002208 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 746361002209 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 746361002210 TPP-binding site; other site 746361002211 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 746361002212 PYR/PP interface [polypeptide binding]; other site 746361002213 dimer interface [polypeptide binding]; other site 746361002214 TPP binding site [chemical binding]; other site 746361002215 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746361002216 Uncharacterized conserved protein [Function unknown]; Region: COG0759 746361002217 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 746361002218 beta-galactosidase; Region: BGL; TIGR03356 746361002219 Predicted membrane protein [Function unknown]; Region: COG1511 746361002220 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 746361002221 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 746361002222 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 746361002223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361002224 S-adenosylmethionine binding site [chemical binding]; other site 746361002225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361002226 non-specific DNA binding site [nucleotide binding]; other site 746361002227 salt bridge; other site 746361002228 sequence-specific DNA binding site [nucleotide binding]; other site 746361002229 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361002230 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361002231 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 746361002232 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 746361002233 Cl- selectivity filter; other site 746361002234 Cl- binding residues [ion binding]; other site 746361002235 pore gating glutamate residue; other site 746361002236 dimer interface [polypeptide binding]; other site 746361002237 H+/Cl- coupling transport residue; other site 746361002238 TrkA-C domain; Region: TrkA_C; pfam02080 746361002239 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 746361002240 UbiA prenyltransferase family; Region: UbiA; pfam01040 746361002241 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 746361002242 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 746361002243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 746361002244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746361002245 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 746361002246 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 746361002247 ATP-binding site [chemical binding]; other site 746361002248 Sugar specificity; other site 746361002249 Pyrimidine base specificity; other site 746361002250 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 746361002251 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 746361002252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361002253 active site 746361002254 motif I; other site 746361002255 motif II; other site 746361002256 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 746361002257 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 746361002258 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 746361002259 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 746361002260 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 746361002261 cell division protein GpsB; Provisional; Region: PRK14127 746361002262 DivIVA domain; Region: DivI1A_domain; TIGR03544 746361002263 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 746361002264 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 746361002265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 746361002266 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 746361002267 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 746361002268 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 746361002269 active site 746361002270 catabolite control protein A; Region: ccpA; TIGR01481 746361002271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361002272 DNA binding site [nucleotide binding] 746361002273 domain linker motif; other site 746361002274 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 746361002275 dimerization interface [polypeptide binding]; other site 746361002276 effector binding site; other site 746361002277 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 746361002278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361002279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361002280 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 746361002281 Colicin V production protein; Region: Colicin_V; pfam02674 746361002282 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 746361002283 MutS domain III; Region: MutS_III; pfam05192 746361002284 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 746361002285 Walker A/P-loop; other site 746361002286 ATP binding site [chemical binding]; other site 746361002287 Q-loop/lid; other site 746361002288 ABC transporter signature motif; other site 746361002289 Walker B; other site 746361002290 D-loop; other site 746361002291 H-loop/switch region; other site 746361002292 Smr domain; Region: Smr; pfam01713 746361002293 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746361002294 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746361002295 catalytic residues [active] 746361002296 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 746361002297 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 746361002298 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 746361002299 active site 746361002300 catalytic residue [active] 746361002301 dimer interface [polypeptide binding]; other site 746361002302 adenylosuccinate lyase; Provisional; Region: PRK07492 746361002303 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 746361002304 tetramer interface [polypeptide binding]; other site 746361002305 active site 746361002306 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 746361002307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361002308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361002309 DNA binding site [nucleotide binding] 746361002310 domain linker motif; other site 746361002311 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 746361002312 dimerization interface [polypeptide binding]; other site 746361002313 ligand binding site [chemical binding]; other site 746361002314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 746361002315 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 746361002316 substrate binding site [chemical binding]; other site 746361002317 dimer interface [polypeptide binding]; other site 746361002318 ATP binding site [chemical binding]; other site 746361002319 D-ribose pyranase; Provisional; Region: PRK11797 746361002320 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 746361002321 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 746361002322 Walker A/P-loop; other site 746361002323 ATP binding site [chemical binding]; other site 746361002324 Q-loop/lid; other site 746361002325 ABC transporter signature motif; other site 746361002326 Walker B; other site 746361002327 D-loop; other site 746361002328 H-loop/switch region; other site 746361002329 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 746361002330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 746361002331 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 746361002332 TM-ABC transporter signature motif; other site 746361002333 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 746361002334 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 746361002335 ligand binding site [chemical binding]; other site 746361002336 dimerization interface [polypeptide binding]; other site 746361002337 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 746361002338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361002339 active site 746361002340 DNA binding site [nucleotide binding] 746361002341 Int/Topo IB signature motif; other site 746361002342 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 746361002343 Domain of unknown function (DUF955); Region: DUF955; pfam06114 746361002344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361002345 non-specific DNA binding site [nucleotide binding]; other site 746361002346 salt bridge; other site 746361002347 sequence-specific DNA binding site [nucleotide binding]; other site 746361002348 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 746361002349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361002350 non-specific DNA binding site [nucleotide binding]; other site 746361002351 salt bridge; other site 746361002352 sequence-specific DNA binding site [nucleotide binding]; other site 746361002353 Phage anti-repressor protein [Transcription]; Region: COG3561 746361002354 ORF6C domain; Region: ORF6C; pfam10552 746361002355 Helix-turn-helix domain; Region: HTH_17; pfam12728 746361002356 putative transcription regulator; Provisional; Region: PHA02503 746361002357 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 746361002358 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 746361002359 AAA domain; Region: AAA_24; pfam13479 746361002360 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 746361002361 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 746361002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361002363 Walker A motif; other site 746361002364 ATP binding site [chemical binding]; other site 746361002365 Walker B motif; other site 746361002366 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 746361002367 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 746361002368 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 746361002369 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 746361002370 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 746361002371 trimer interface [polypeptide binding]; other site 746361002372 active site 746361002373 Prophage protein (DUF1660); Region: DUF1660; pfam07874 746361002374 Protein of unknown function (DUF722); Region: DUF722; pfam05263 746361002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361002376 Integrase core domain; Region: rve; pfam00665 746361002377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361002378 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361002379 Walker A motif; other site 746361002380 ATP binding site [chemical binding]; other site 746361002381 Walker B motif; other site 746361002382 arginine finger; other site 746361002383 Terminase small subunit; Region: Terminase_2; pfam03592 746361002384 Phage terminase large subunit; Region: Terminase_3; cl12054 746361002385 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 746361002386 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 746361002387 hypothetical protein; Provisional; Region: PRK14553 746361002388 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 746361002389 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 746361002390 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 746361002391 Phage capsid family; Region: Phage_capsid; pfam05065 746361002392 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 746361002393 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 746361002394 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 746361002395 Phage tail protein; Region: Phage_tail_3; pfam08813 746361002396 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 746361002397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 746361002398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 746361002399 catalytic residue [active] 746361002400 gp58-like protein; Region: Gp58; pfam07902 746361002401 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 746361002402 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 746361002403 active site 746361002404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361002405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361002406 Abi-like protein; Region: Abi_2; pfam07751 746361002407 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361002408 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 746361002409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361002410 putative substrate translocation pore; other site 746361002411 Transcriptional regulators [Transcription]; Region: GntR; COG1802 746361002412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 746361002413 DNA-binding site [nucleotide binding]; DNA binding site 746361002414 FCD domain; Region: FCD; pfam07729 746361002415 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 746361002416 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 746361002417 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 746361002418 mannonate dehydratase; Provisional; Region: PRK03906 746361002419 mannonate dehydratase; Region: uxuA; TIGR00695 746361002420 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 746361002421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361002422 putative substrate translocation pore; other site 746361002423 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 746361002424 active site 746361002425 catalytic residues [active] 746361002426 Glucuronate isomerase; Region: UxaC; pfam02614 746361002427 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 746361002428 potential frameshift: common BLAST hit: gi|15673609|ref|NP_267783.1| 2-dehydro-3-deoxygluconokinase 746361002429 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 746361002430 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 746361002431 active site 746361002432 intersubunit interface [polypeptide binding]; other site 746361002433 catalytic residue [active] 746361002434 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 746361002435 PRD domain; Region: PRD; pfam00874 746361002436 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 746361002437 active site 746361002438 P-loop; other site 746361002439 phosphorylation site [posttranslational modification] 746361002440 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 746361002441 active site 746361002442 phosphorylation site [posttranslational modification] 746361002443 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 746361002444 active site 746361002445 P-loop; other site 746361002446 phosphorylation site [posttranslational modification] 746361002447 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 746361002448 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 746361002449 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 746361002450 TPP-binding site [chemical binding]; other site 746361002451 dimer interface [polypeptide binding]; other site 746361002452 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 746361002453 PYR/PP interface [polypeptide binding]; other site 746361002454 dimer interface [polypeptide binding]; other site 746361002455 TPP binding site [chemical binding]; other site 746361002456 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746361002457 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 746361002458 amphipathic channel; other site 746361002459 Asn-Pro-Ala signature motifs; other site 746361002460 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 746361002461 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 746361002462 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 746361002463 nudix motif; other site 746361002464 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 746361002465 nudix motif; other site 746361002466 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 746361002467 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 746361002468 dimer interface [polypeptide binding]; other site 746361002469 active site 746361002470 catalytic residue [active] 746361002471 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 746361002472 MgtC family; Region: MgtC; pfam02308 746361002473 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 746361002474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 746361002475 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 746361002476 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 746361002477 signal recognition particle protein; Provisional; Region: PRK10867 746361002478 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 746361002479 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 746361002480 P loop; other site 746361002481 GTP binding site [chemical binding]; other site 746361002482 Signal peptide binding domain; Region: SRP_SPB; pfam02978 746361002483 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 746361002484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746361002485 Coenzyme A binding pocket [chemical binding]; other site 746361002486 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 746361002487 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 746361002488 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 746361002489 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 746361002490 Predicted membrane protein [Function unknown]; Region: COG4392 746361002491 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 746361002492 Uncharacterized conserved protein [Function unknown]; Region: COG2461 746361002493 Family of unknown function (DUF438); Region: DUF438; pfam04282 746361002494 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 746361002495 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 746361002496 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 746361002497 nucleotide binding site [chemical binding]; other site 746361002498 homotetrameric interface [polypeptide binding]; other site 746361002499 putative phosphate binding site [ion binding]; other site 746361002500 putative allosteric binding site; other site 746361002501 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 746361002502 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 746361002503 putative catalytic cysteine [active] 746361002504 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 746361002505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361002506 dimerization interface [polypeptide binding]; other site 746361002507 putative DNA binding site [nucleotide binding]; other site 746361002508 putative Zn2+ binding site [ion binding]; other site 746361002509 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 746361002510 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 746361002511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361002512 active site 746361002513 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 746361002514 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 746361002515 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 746361002516 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 746361002517 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 746361002518 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 746361002519 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 746361002520 catalytic site [active] 746361002521 subunit interface [polypeptide binding]; other site 746361002522 potential frameshift: common BLAST hit: gi|385837873|ref|YP_005875503.1| prophage pi3 protein 01 746361002523 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 746361002524 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 746361002525 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 746361002526 metal binding site [ion binding]; metal-binding site 746361002527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002528 Transposase; Region: HTH_Tnp_1; pfam01527 746361002529 putative transposase OrfB; Reviewed; Region: PHA02517 746361002530 HTH-like domain; Region: HTH_21; pfam13276 746361002531 Integrase core domain; Region: rve; pfam00665 746361002532 Integrase core domain; Region: rve_3; pfam13683 746361002533 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 746361002534 Low molecular weight phosphatase family; Region: LMWPc; cd00115 746361002535 active site 746361002536 phosphodiesterase YaeI; Provisional; Region: PRK11340 746361002537 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 746361002538 putative active site [active] 746361002539 putative metal binding site [ion binding]; other site 746361002540 CHAP domain; Region: CHAP; pfam05257 746361002541 conserved hypothetical protein; Region: TIGR02328 746361002542 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 746361002543 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 746361002544 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 746361002545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361002546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361002547 active site 746361002548 phosphorylation site [posttranslational modification] 746361002549 intermolecular recognition site; other site 746361002550 dimerization interface [polypeptide binding]; other site 746361002551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361002552 DNA binding site [nucleotide binding] 746361002553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361002554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 746361002555 dimerization interface [polypeptide binding]; other site 746361002556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361002557 dimer interface [polypeptide binding]; other site 746361002558 phosphorylation site [posttranslational modification] 746361002559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361002560 ATP binding site [chemical binding]; other site 746361002561 Mg2+ binding site [ion binding]; other site 746361002562 G-X-G motif; other site 746361002563 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 746361002564 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 746361002565 Nitrogen regulatory protein P-II; Region: P-II; smart00938 746361002566 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 746361002567 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 746361002568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361002569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746361002570 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 746361002571 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 746361002572 homodimer interface [polypeptide binding]; other site 746361002573 active site 746361002574 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 746361002575 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 746361002576 Cell division protein FtsQ; Region: FtsQ; pfam03799 746361002577 GTPase CgtA; Reviewed; Region: obgE; PRK12297 746361002578 GTP1/OBG; Region: GTP1_OBG; pfam01018 746361002579 Obg GTPase; Region: Obg; cd01898 746361002580 G1 box; other site 746361002581 GTP/Mg2+ binding site [chemical binding]; other site 746361002582 Switch I region; other site 746361002583 G2 box; other site 746361002584 G3 box; other site 746361002585 Switch II region; other site 746361002586 G4 box; other site 746361002587 G5 box; other site 746361002588 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 746361002589 potential frameshift: common BLAST hit: gi|116512392|ref|YP_809608.1| cell surface protein 746361002590 WxL domain surface cell wall-binding; Region: WxL; pfam13731 746361002591 WxL domain surface cell wall-binding; Region: WxL; pfam13731 746361002592 WxL domain surface cell wall-binding; Region: WxL; pfam13731 746361002593 potential frameshift: common BLAST hit: gi|281491853|ref|YP_003353833.1| Cell surface protein with WxL domain 746361002594 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 746361002595 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 746361002596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361002597 non-specific DNA binding site [nucleotide binding]; other site 746361002598 salt bridge; other site 746361002599 sequence-specific DNA binding site [nucleotide binding]; other site 746361002600 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 746361002601 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 746361002602 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746361002603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746361002604 Serine hydrolase (FSH1); Region: FSH1; pfam03959 746361002605 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 746361002606 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 746361002607 active site 746361002608 trimer interface [polypeptide binding]; other site 746361002609 allosteric site; other site 746361002610 active site lid [active] 746361002611 hexamer (dimer of trimers) interface [polypeptide binding]; other site 746361002612 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 746361002613 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 746361002614 dimer interface [polypeptide binding]; other site 746361002615 active site 746361002616 putative acyltransferase; Provisional; Region: PRK05790 746361002617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 746361002618 dimer interface [polypeptide binding]; other site 746361002619 active site 746361002620 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 746361002621 homodimer interface [polypeptide binding]; other site 746361002622 catalytic residues [active] 746361002623 NAD binding site [chemical binding]; other site 746361002624 substrate binding pocket [chemical binding]; other site 746361002625 flexible flap; other site 746361002626 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 746361002627 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 746361002628 KH domain; Region: KH_4; pfam13083 746361002629 Ferrochelatase; Region: Ferrochelatase; pfam00762 746361002630 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 746361002631 C-terminal domain interface [polypeptide binding]; other site 746361002632 active site 746361002633 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 746361002634 active site 746361002635 N-terminal domain interface [polypeptide binding]; other site 746361002636 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 746361002637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746361002638 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 746361002639 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 746361002640 RimM N-terminal domain; Region: RimM; pfam01782 746361002641 PRC-barrel domain; Region: PRC; pfam05239 746361002642 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 746361002643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 746361002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 746361002645 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 746361002646 dihydrodipicolinate reductase; Provisional; Region: PRK00048 746361002647 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 746361002648 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 746361002649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746361002650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361002651 Coenzyme A binding pocket [chemical binding]; other site 746361002652 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 746361002653 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 746361002654 active site 746361002655 NTP binding site [chemical binding]; other site 746361002656 metal binding triad [ion binding]; metal-binding site 746361002657 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 746361002658 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 746361002659 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 746361002660 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 746361002661 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 746361002662 putative active site [active] 746361002663 metal binding site [ion binding]; metal-binding site 746361002664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361002665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361002666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 746361002667 dimerization interface [polypeptide binding]; other site 746361002668 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746361002669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361002670 Walker A/P-loop; other site 746361002671 ATP binding site [chemical binding]; other site 746361002672 Q-loop/lid; other site 746361002673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361002674 ABC transporter signature motif; other site 746361002675 Walker B; other site 746361002676 D-loop; other site 746361002677 ABC transporter; Region: ABC_tran_2; pfam12848 746361002678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361002679 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 746361002680 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746361002681 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 746361002682 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 746361002683 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 746361002684 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 746361002685 active site 746361002686 FMN binding site [chemical binding]; other site 746361002687 substrate binding site [chemical binding]; other site 746361002688 catalytic residues [active] 746361002689 homodimer interface [polypeptide binding]; other site 746361002690 Predicted membrane protein [Function unknown]; Region: COG4905 746361002691 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 746361002692 Enterocin A Immunity; Region: EntA_Immun; pfam08951 746361002693 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 746361002694 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 746361002695 catalytic Zn binding site [ion binding]; other site 746361002696 NAD(P) binding site [chemical binding]; other site 746361002697 structural Zn binding site [ion binding]; other site 746361002698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361002699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361002700 DNA binding site [nucleotide binding] 746361002701 domain linker motif; other site 746361002702 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 746361002703 ligand binding site [chemical binding]; other site 746361002704 dimerization interface [polypeptide binding]; other site 746361002705 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 746361002706 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 746361002707 substrate binding site [chemical binding]; other site 746361002708 hexamer interface [polypeptide binding]; other site 746361002709 metal binding site [ion binding]; metal-binding site 746361002710 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 746361002711 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 746361002712 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 746361002713 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 746361002714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361002715 nucleotide binding site [chemical binding]; other site 746361002716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361002717 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746361002718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361002719 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 746361002720 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 746361002721 thymidylate synthase; Reviewed; Region: thyA; PRK01827 746361002722 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 746361002723 dimerization interface [polypeptide binding]; other site 746361002724 active site 746361002725 potential frameshift: common BLAST hit: gi|116512334|ref|YP_809550.1| surface antigen 746361002726 Transcriptional regulators [Transcription]; Region: MarR; COG1846 746361002727 MarR family; Region: MarR_2; pfam12802 746361002728 putative transporter; Provisional; Region: PRK10504 746361002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361002730 putative substrate translocation pore; other site 746361002731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361002732 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 746361002733 classical (c) SDRs; Region: SDR_c; cd05233 746361002734 NAD(P) binding site [chemical binding]; other site 746361002735 active site 746361002736 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 746361002737 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 746361002738 Uncharacterized conserved protein [Function unknown]; Region: COG1359 746361002739 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 746361002740 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 746361002741 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 746361002742 ATP binding site [chemical binding]; other site 746361002743 active site 746361002744 substrate binding site [chemical binding]; other site 746361002745 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 746361002746 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 746361002747 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 746361002748 putative active site [active] 746361002749 catalytic triad [active] 746361002750 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 746361002751 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 746361002752 dimerization interface [polypeptide binding]; other site 746361002753 ATP binding site [chemical binding]; other site 746361002754 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 746361002755 dimerization interface [polypeptide binding]; other site 746361002756 ATP binding site [chemical binding]; other site 746361002757 amidophosphoribosyltransferase; Provisional; Region: PRK07272 746361002758 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 746361002759 active site 746361002760 tetramer interface [polypeptide binding]; other site 746361002761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361002762 active site 746361002763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002764 Transposase; Region: HTH_Tnp_1; pfam01527 746361002765 potential frameshift: common BLAST hit: gi|116628154|ref|YP_820773.1| transposase 746361002766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002767 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002769 Transposase; Region: HTH_Tnp_1; cl17663 746361002770 putative transposase OrfB; Reviewed; Region: PHA02517 746361002771 HTH-like domain; Region: HTH_21; pfam13276 746361002772 Integrase core domain; Region: rve; pfam00665 746361002773 Integrase core domain; Region: rve_2; pfam13333 746361002774 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 746361002775 Clp amino terminal domain; Region: Clp_N; pfam02861 746361002776 Clp amino terminal domain; Region: Clp_N; pfam02861 746361002777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361002778 Walker A motif; other site 746361002779 ATP binding site [chemical binding]; other site 746361002780 Walker B motif; other site 746361002781 arginine finger; other site 746361002782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361002783 Walker A motif; other site 746361002784 ATP binding site [chemical binding]; other site 746361002785 Walker B motif; other site 746361002786 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 746361002787 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 746361002788 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 746361002789 dimerization interface [polypeptide binding]; other site 746361002790 putative ATP binding site [chemical binding]; other site 746361002791 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 746361002792 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 746361002793 active site 746361002794 substrate binding site [chemical binding]; other site 746361002795 cosubstrate binding site; other site 746361002796 catalytic site [active] 746361002797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361002798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361002799 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 746361002800 Walker A/P-loop; other site 746361002801 ATP binding site [chemical binding]; other site 746361002802 Q-loop/lid; other site 746361002803 ABC transporter signature motif; other site 746361002804 Walker B; other site 746361002805 D-loop; other site 746361002806 H-loop/switch region; other site 746361002807 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361002808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361002809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746361002810 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 746361002811 NADP binding site [chemical binding]; other site 746361002812 putative substrate binding site [chemical binding]; other site 746361002813 active site 746361002814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361002815 active site 746361002816 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 746361002817 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 746361002818 purine monophosphate binding site [chemical binding]; other site 746361002819 dimer interface [polypeptide binding]; other site 746361002820 putative catalytic residues [active] 746361002821 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 746361002822 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 746361002823 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 746361002824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361002825 motif II; other site 746361002826 potential frameshift: common BLAST hit: gi|116512310|ref|YP_809526.1| major facilitator superfamily permease 746361002827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361002828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361002829 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 746361002830 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 746361002831 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 746361002832 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 746361002833 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 746361002834 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 746361002835 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 746361002836 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 746361002837 ATP-grasp domain; Region: ATP-grasp; pfam02222 746361002838 Cupin domain; Region: Cupin_2; pfam07883 746361002839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361002840 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746361002841 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 746361002842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 746361002843 Integrase core domain; Region: rve; pfam00665 746361002844 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 746361002845 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 746361002846 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361002847 nucleotide binding site [chemical binding]; other site 746361002848 butyrate kinase; Provisional; Region: PRK03011 746361002849 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 746361002850 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361002851 nucleotide binding site [chemical binding]; other site 746361002852 GMP synthase; Reviewed; Region: guaA; PRK00074 746361002853 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 746361002854 AMP/PPi binding site [chemical binding]; other site 746361002855 candidate oxyanion hole; other site 746361002856 catalytic triad [active] 746361002857 potential glutamine specificity residues [chemical binding]; other site 746361002858 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 746361002859 ATP Binding subdomain [chemical binding]; other site 746361002860 Dimerization subdomain; other site 746361002861 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 746361002862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002863 dimer interface [polypeptide binding]; other site 746361002864 conserved gate region; other site 746361002865 ABC-ATPase subunit interface; other site 746361002866 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 746361002867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002868 dimer interface [polypeptide binding]; other site 746361002869 conserved gate region; other site 746361002870 ABC-ATPase subunit interface; other site 746361002871 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 746361002872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 746361002873 potential frameshift: common BLAST hit: gi|116512288|ref|YP_809504.1| integral membrane protein 746361002874 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 746361002875 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 746361002876 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 746361002877 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 746361002878 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 746361002879 Cl binding site [ion binding]; other site 746361002880 oligomer interface [polypeptide binding]; other site 746361002881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361002882 MarR family; Region: MarR; pfam01047 746361002883 potential frameshift: common BLAST hit: gi|116512281|ref|YP_809497.1| 1-deoxy-D-xylulose-5-phosphate synthase 746361002884 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 746361002885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361002886 NAD(P) binding site [chemical binding]; other site 746361002887 active site 746361002888 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 746361002889 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361002890 DNA binding residues [nucleotide binding] 746361002891 putative dimer interface [polypeptide binding]; other site 746361002892 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 746361002893 EamA-like transporter family; Region: EamA; pfam00892 746361002894 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361002895 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 746361002896 metal binding site 2 [ion binding]; metal-binding site 746361002897 putative DNA binding helix; other site 746361002898 metal binding site 1 [ion binding]; metal-binding site 746361002899 dimer interface [polypeptide binding]; other site 746361002900 structural Zn2+ binding site [ion binding]; other site 746361002901 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 746361002902 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 746361002903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 746361002904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361002905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361002906 putative DNA binding site [nucleotide binding]; other site 746361002907 putative Zn2+ binding site [ion binding]; other site 746361002908 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 746361002909 dimer interface [polypeptide binding]; other site 746361002910 FMN binding site [chemical binding]; other site 746361002911 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 746361002912 anthranilate synthase component I; Provisional; Region: PRK13570 746361002913 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 746361002914 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 746361002915 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 746361002916 Glutamine amidotransferase class-I; Region: GATase; pfam00117 746361002917 glutamine binding [chemical binding]; other site 746361002918 catalytic triad [active] 746361002919 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 746361002920 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 746361002921 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 746361002922 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 746361002923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 746361002924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361002925 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 746361002926 active site 746361002927 ribulose/triose binding site [chemical binding]; other site 746361002928 phosphate binding site [ion binding]; other site 746361002929 substrate (anthranilate) binding pocket [chemical binding]; other site 746361002930 product (indole) binding pocket [chemical binding]; other site 746361002931 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 746361002932 active site 746361002933 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 746361002934 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 746361002935 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 746361002936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361002937 catalytic residue [active] 746361002938 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 746361002939 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 746361002940 substrate binding site [chemical binding]; other site 746361002941 active site 746361002942 catalytic residues [active] 746361002943 heterodimer interface [polypeptide binding]; other site 746361002944 CAT RNA binding domain; Region: CAT_RBD; pfam03123 746361002945 PRD domain; Region: PRD; pfam00874 746361002946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361002947 Integrase core domain; Region: rve; pfam00665 746361002948 Integrase core domain; Region: rve_3; pfam13683 746361002949 Transposase; Region: HTH_Tnp_1; pfam01527 746361002950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361002951 PRD domain; Region: PRD; pfam00874 746361002952 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 746361002953 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 746361002954 active site turn [active] 746361002955 phosphorylation site [posttranslational modification] 746361002956 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 746361002957 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 746361002958 HPr interaction site; other site 746361002959 glycerol kinase (GK) interaction site [polypeptide binding]; other site 746361002960 active site 746361002961 phosphorylation site [posttranslational modification] 746361002962 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 746361002963 beta-galactosidase; Region: BGL; TIGR03356 746361002964 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 746361002965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 746361002966 DNA-binding site [nucleotide binding]; DNA binding site 746361002967 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 746361002968 TrkA-C domain; Region: TrkA_C; pfam02080 746361002969 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 746361002970 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 746361002971 Walker A/P-loop; other site 746361002972 ATP binding site [chemical binding]; other site 746361002973 Q-loop/lid; other site 746361002974 ABC transporter signature motif; other site 746361002975 Walker B; other site 746361002976 D-loop; other site 746361002977 H-loop/switch region; other site 746361002978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 746361002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361002980 dimer interface [polypeptide binding]; other site 746361002981 conserved gate region; other site 746361002982 putative PBP binding loops; other site 746361002983 ABC-ATPase subunit interface; other site 746361002984 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 746361002985 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 746361002986 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 746361002987 potential frameshift: common BLAST hit: gi|116512251|ref|YP_809467.1| phosphoadenosine phosphosulfate sulfotransferase 746361002988 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 746361002989 ParB-like nuclease domain; Region: ParB; smart00470 746361002990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361002991 non-specific DNA binding site [nucleotide binding]; other site 746361002992 salt bridge; other site 746361002993 sequence-specific DNA binding site [nucleotide binding]; other site 746361002994 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 746361002995 Cation efflux family; Region: Cation_efflux; pfam01545 746361002996 Phosphate-starvation-inducible E; Region: PsiE; cl01264 746361002997 pantothenate kinase; Provisional; Region: PRK05439 746361002998 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 746361002999 ATP-binding site [chemical binding]; other site 746361003000 CoA-binding site [chemical binding]; other site 746361003001 Mg2+-binding site [ion binding]; other site 746361003002 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746361003003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361003004 S-adenosylmethionine binding site [chemical binding]; other site 746361003005 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 746361003006 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 746361003007 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 746361003008 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 746361003009 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 746361003010 intersubunit interface [polypeptide binding]; other site 746361003011 active site 746361003012 catalytic residue [active] 746361003013 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 746361003014 active site 746361003015 catalytic motif [active] 746361003016 Zn binding site [ion binding]; other site 746361003017 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 746361003018 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 746361003019 ligand binding site [chemical binding]; other site 746361003020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 746361003021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 746361003022 DNA-binding site [nucleotide binding]; DNA binding site 746361003023 UTRA domain; Region: UTRA; pfam07702 746361003024 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 746361003025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361003026 dimer interface [polypeptide binding]; other site 746361003027 phosphorylation site [posttranslational modification] 746361003028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361003029 ATP binding site [chemical binding]; other site 746361003030 Mg2+ binding site [ion binding]; other site 746361003031 G-X-G motif; other site 746361003032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361003033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361003034 active site 746361003035 phosphorylation site [posttranslational modification] 746361003036 intermolecular recognition site; other site 746361003037 dimerization interface [polypeptide binding]; other site 746361003038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361003039 DNA binding site [nucleotide binding] 746361003040 putative DNA-binding protein; Validated; Region: PRK00118 746361003041 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 746361003042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003043 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361003044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003045 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361003046 HTH-like domain; Region: HTH_21; pfam13276 746361003047 Integrase core domain; Region: rve; pfam00665 746361003048 Integrase core domain; Region: rve_2; pfam13333 746361003049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003050 Transposase; Region: HTH_Tnp_1; pfam01527 746361003051 HTH-like domain; Region: HTH_21; pfam13276 746361003052 Integrase core domain; Region: rve; pfam00665 746361003053 Integrase core domain; Region: rve_3; cl15866 746361003054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361003055 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361003056 Walker A motif; other site 746361003057 ATP binding site [chemical binding]; other site 746361003058 Walker B motif; other site 746361003059 arginine finger; other site 746361003060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361003061 Integrase core domain; Region: rve; pfam00665 746361003062 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746361003063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361003064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361003065 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 746361003066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 746361003067 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361003068 Ligand Binding Site [chemical binding]; other site 746361003069 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 746361003070 TraX protein; Region: TraX; cl05434 746361003071 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 746361003072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 746361003073 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 746361003074 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 746361003075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361003076 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 746361003077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361003078 motif II; other site 746361003079 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 746361003080 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 746361003081 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 746361003082 catalytic residues [active] 746361003083 dimer interface [polypeptide binding]; other site 746361003084 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 746361003085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746361003086 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 746361003087 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 746361003088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746361003089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746361003090 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 746361003091 IMP binding site; other site 746361003092 dimer interface [polypeptide binding]; other site 746361003093 interdomain contacts; other site 746361003094 partial ornithine binding site; other site 746361003095 potential frameshift: common BLAST hit: gi|385838480|ref|YP_005876110.1| flagellar hook-length control protein FliK 746361003096 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 746361003097 WxL domain surface cell wall-binding; Region: WxL; pfam13731 746361003098 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 746361003099 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 746361003100 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 746361003101 amphipathic channel; other site 746361003102 Asn-Pro-Ala signature motifs; other site 746361003103 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 746361003104 hydroxyglutarate oxidase; Provisional; Region: PRK11728 746361003105 glycerol kinase; Provisional; Region: glpK; PRK00047 746361003106 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 746361003107 N- and C-terminal domain interface [polypeptide binding]; other site 746361003108 active site 746361003109 MgATP binding site [chemical binding]; other site 746361003110 catalytic site [active] 746361003111 metal binding site [ion binding]; metal-binding site 746361003112 glycerol binding site [chemical binding]; other site 746361003113 homotetramer interface [polypeptide binding]; other site 746361003114 homodimer interface [polypeptide binding]; other site 746361003115 FBP binding site [chemical binding]; other site 746361003116 protein IIAGlc interface [polypeptide binding]; other site 746361003117 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 746361003118 pseudouridine synthase; Region: TIGR00093 746361003119 probable active site [active] 746361003120 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 746361003121 Repair protein; Region: Repair_PSII; pfam04536 746361003122 hypothetical protein; Provisional; Region: PRK12495 746361003123 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 746361003124 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 746361003125 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 746361003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361003127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361003128 putative substrate translocation pore; other site 746361003129 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 746361003130 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 746361003131 FAD binding pocket [chemical binding]; other site 746361003132 FAD binding motif [chemical binding]; other site 746361003133 phosphate binding motif [ion binding]; other site 746361003134 beta-alpha-beta structure motif; other site 746361003135 NAD binding pocket [chemical binding]; other site 746361003136 Iron coordination center [ion binding]; other site 746361003137 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 746361003138 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 746361003139 heterodimer interface [polypeptide binding]; other site 746361003140 active site 746361003141 FMN binding site [chemical binding]; other site 746361003142 homodimer interface [polypeptide binding]; other site 746361003143 substrate binding site [chemical binding]; other site 746361003144 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 746361003145 active site 746361003146 dimer interface [polypeptide binding]; other site 746361003147 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 746361003148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361003149 S-adenosylmethionine binding site [chemical binding]; other site 746361003150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 746361003151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 746361003152 substrate binding pocket [chemical binding]; other site 746361003153 chain length determination region; other site 746361003154 substrate-Mg2+ binding site; other site 746361003155 catalytic residues [active] 746361003156 aspartate-rich region 1; other site 746361003157 active site lid residues [active] 746361003158 aspartate-rich region 2; other site 746361003159 Predicted membrane protein [Function unknown]; Region: COG4769 746361003160 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 746361003161 trimer interface [polypeptide binding]; other site 746361003162 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 746361003163 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 746361003164 active site 746361003165 tetramer interface; other site 746361003166 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 746361003167 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 746361003168 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 746361003169 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 746361003170 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 746361003171 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 746361003172 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 746361003173 active site 746361003174 dimer interface [polypeptide binding]; other site 746361003175 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 746361003176 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 746361003177 active site 746361003178 ADP/pyrophosphate binding site [chemical binding]; other site 746361003179 dimerization interface [polypeptide binding]; other site 746361003180 allosteric effector site; other site 746361003181 fructose-1,6-bisphosphate binding site; other site 746361003182 pyruvate kinase; Provisional; Region: PRK05826 746361003183 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 746361003184 domain interfaces; other site 746361003185 active site 746361003186 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 746361003187 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 746361003188 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361003189 NAD binding site [chemical binding]; other site 746361003190 dimer interface [polypeptide binding]; other site 746361003191 substrate binding site [chemical binding]; other site 746361003192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 746361003193 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 746361003194 TM-ABC transporter signature motif; other site 746361003195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 746361003196 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 746361003197 TM-ABC transporter signature motif; other site 746361003198 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 746361003199 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 746361003200 Walker A/P-loop; other site 746361003201 ATP binding site [chemical binding]; other site 746361003202 Q-loop/lid; other site 746361003203 ABC transporter signature motif; other site 746361003204 Walker B; other site 746361003205 D-loop; other site 746361003206 H-loop/switch region; other site 746361003207 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 746361003208 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 746361003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361003210 S-adenosylmethionine binding site [chemical binding]; other site 746361003211 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 746361003212 Domain of unknown function (DUF814); Region: DUF814; pfam05670 746361003213 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 746361003214 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 746361003215 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 746361003216 ArsC family; Region: ArsC; pfam03960 746361003217 putative catalytic residues [active] 746361003218 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 746361003219 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 746361003220 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 746361003221 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 746361003222 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 746361003223 active site 746361003224 metal binding site [ion binding]; metal-binding site 746361003225 DNA binding site [nucleotide binding] 746361003226 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 746361003227 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 746361003228 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 746361003229 Walker A/P-loop; other site 746361003230 ATP binding site [chemical binding]; other site 746361003231 Q-loop/lid; other site 746361003232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361003233 ABC transporter signature motif; other site 746361003234 Walker B; other site 746361003235 D-loop; other site 746361003236 H-loop/switch region; other site 746361003237 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 746361003238 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 746361003239 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 746361003240 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 746361003241 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 746361003242 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746361003243 ABC-ATPase subunit interface; other site 746361003244 dimer interface [polypeptide binding]; other site 746361003245 putative PBP binding regions; other site 746361003246 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 746361003247 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 746361003248 metal binding site [ion binding]; metal-binding site 746361003249 plasmid segregation protein ParM; Provisional; Region: PRK13917 746361003250 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 746361003251 Mg binding site [ion binding]; other site 746361003252 nucleotide binding site [chemical binding]; other site 746361003253 putative protofilament interface [polypeptide binding]; other site 746361003254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003255 non-specific DNA binding site [nucleotide binding]; other site 746361003256 salt bridge; other site 746361003257 sequence-specific DNA binding site [nucleotide binding]; other site 746361003258 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361003259 MULE transposase domain; Region: MULE; pfam10551 746361003260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003261 non-specific DNA binding site [nucleotide binding]; other site 746361003262 salt bridge; other site 746361003263 sequence-specific DNA binding site [nucleotide binding]; other site 746361003264 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361003265 putative transposase OrfB; Reviewed; Region: PHA02517 746361003266 HTH-like domain; Region: HTH_21; pfam13276 746361003267 Integrase core domain; Region: rve; pfam00665 746361003268 Integrase core domain; Region: rve_3; pfam13683 746361003269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003270 Transposase; Region: HTH_Tnp_1; pfam01527 746361003271 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361003272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003273 non-specific DNA binding site [nucleotide binding]; other site 746361003274 salt bridge; other site 746361003275 sequence-specific DNA binding site [nucleotide binding]; other site 746361003276 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 746361003277 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 746361003278 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 746361003279 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 746361003280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 746361003281 DNA-binding site [nucleotide binding]; DNA binding site 746361003282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361003284 homodimer interface [polypeptide binding]; other site 746361003285 catalytic residue [active] 746361003286 legume lectins; Region: lectin_L-type; cd01951 746361003287 homotetramer interaction site [polypeptide binding]; other site 746361003288 carbohydrate binding site [chemical binding]; other site 746361003289 metal binding site [ion binding]; metal-binding site 746361003290 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 746361003291 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 746361003292 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 746361003293 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 746361003294 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 746361003295 glutamine binding [chemical binding]; other site 746361003296 catalytic triad [active] 746361003297 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 746361003298 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 746361003299 chorismate binding enzyme; Region: Chorismate_bind; cl10555 746361003300 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 746361003301 substrate-cofactor binding pocket; other site 746361003302 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 746361003303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361003304 catalytic residue [active] 746361003305 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 746361003306 ArsC family; Region: ArsC; pfam03960 746361003307 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 746361003308 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 746361003309 Domain of unknown function (DUF303); Region: DUF303; pfam03629 746361003310 Domain of unknown function (DUF303); Region: DUF303; pfam03629 746361003311 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 746361003312 Domain of unknown function (DUF303); Region: DUF303; pfam03629 746361003313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 746361003314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 746361003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361003316 dimer interface [polypeptide binding]; other site 746361003317 conserved gate region; other site 746361003318 putative PBP binding loops; other site 746361003319 ABC-ATPase subunit interface; other site 746361003320 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 746361003321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361003322 dimer interface [polypeptide binding]; other site 746361003323 conserved gate region; other site 746361003324 putative PBP binding loops; other site 746361003325 ABC-ATPase subunit interface; other site 746361003326 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 746361003327 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746361003328 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 746361003329 NodB motif; other site 746361003330 active site 746361003331 catalytic site [active] 746361003332 metal binding site [ion binding]; metal-binding site 746361003333 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 746361003334 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 746361003335 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 746361003336 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 746361003337 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 746361003338 active site 746361003339 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 746361003340 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 746361003341 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 746361003342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 746361003343 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 746361003344 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 746361003345 GTP/Mg2+ binding site [chemical binding]; other site 746361003346 G4 box; other site 746361003347 G5 box; other site 746361003348 G1 box; other site 746361003349 Switch I region; other site 746361003350 G2 box; other site 746361003351 G3 box; other site 746361003352 Switch II region; other site 746361003353 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 746361003354 RNA/DNA hybrid binding site [nucleotide binding]; other site 746361003355 active site 746361003356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003357 non-specific DNA binding site [nucleotide binding]; other site 746361003358 salt bridge; other site 746361003359 sequence-specific DNA binding site [nucleotide binding]; other site 746361003360 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361003361 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 746361003362 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 746361003363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361003364 catalytic residue [active] 746361003365 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746361003366 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746361003367 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 746361003368 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 746361003369 homodimer interface [polypeptide binding]; other site 746361003370 substrate-cofactor binding pocket; other site 746361003371 catalytic residue [active] 746361003372 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 746361003373 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 746361003374 active site 746361003375 substrate binding site [chemical binding]; other site 746361003376 trimer interface [polypeptide binding]; other site 746361003377 CoA binding site [chemical binding]; other site 746361003378 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 746361003379 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 746361003380 active site 746361003381 dimer interface [polypeptide binding]; other site 746361003382 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 746361003383 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 746361003384 active site 746361003385 FMN binding site [chemical binding]; other site 746361003386 substrate binding site [chemical binding]; other site 746361003387 3Fe-4S cluster binding site [ion binding]; other site 746361003388 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 746361003389 domain interface; other site 746361003390 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 746361003391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746361003392 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 746361003393 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 746361003394 active site 746361003395 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746361003396 substrate binding site [chemical binding]; other site 746361003397 catalytic residues [active] 746361003398 dimer interface [polypeptide binding]; other site 746361003399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 746361003400 glutamate racemase; Provisional; Region: PRK00865 746361003401 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 746361003402 active site 746361003403 dimerization interface [polypeptide binding]; other site 746361003404 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 746361003405 active site 746361003406 metal binding site [ion binding]; metal-binding site 746361003407 homotetramer interface [polypeptide binding]; other site 746361003408 FOG: CBS domain [General function prediction only]; Region: COG0517 746361003409 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 746361003410 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 746361003411 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 746361003412 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 746361003413 active site 746361003414 catalytic residues [active] 746361003415 DNA binding site [nucleotide binding] 746361003416 Int/Topo IB signature motif; other site 746361003417 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 746361003418 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 746361003419 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 746361003420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361003421 RNA binding surface [nucleotide binding]; other site 746361003422 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 746361003423 active site 746361003424 Predicted membrane protein [Function unknown]; Region: COG3601 746361003425 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 746361003426 potential frameshift: common BLAST hit: gi|385838377|ref|YP_005876007.1| Cell wall surface anchor family protein 746361003427 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 746361003428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361003429 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 746361003430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361003431 Walker A/P-loop; other site 746361003432 ATP binding site [chemical binding]; other site 746361003433 Q-loop/lid; other site 746361003434 ABC transporter signature motif; other site 746361003435 Walker B; other site 746361003436 D-loop; other site 746361003437 H-loop/switch region; other site 746361003438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361003439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361003440 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 746361003441 Walker A/P-loop; other site 746361003442 ATP binding site [chemical binding]; other site 746361003443 Q-loop/lid; other site 746361003444 ABC transporter signature motif; other site 746361003445 Walker B; other site 746361003446 D-loop; other site 746361003447 H-loop/switch region; other site 746361003448 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361003449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003450 non-specific DNA binding site [nucleotide binding]; other site 746361003451 salt bridge; other site 746361003452 sequence-specific DNA binding site [nucleotide binding]; other site 746361003453 Predicted transcriptional regulator [Transcription]; Region: COG2932 746361003454 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 746361003455 Catalytic site [active] 746361003456 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361003457 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 746361003458 23S rRNA interface [nucleotide binding]; other site 746361003459 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 746361003460 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 746361003461 core dimer interface [polypeptide binding]; other site 746361003462 peripheral dimer interface [polypeptide binding]; other site 746361003463 L10 interface [polypeptide binding]; other site 746361003464 L11 interface [polypeptide binding]; other site 746361003465 putative EF-Tu interaction site [polypeptide binding]; other site 746361003466 putative EF-G interaction site [polypeptide binding]; other site 746361003467 MarR family; Region: MarR_2; pfam12802 746361003468 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 746361003469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361003470 putative substrate translocation pore; other site 746361003471 potential frameshift: common BLAST hit: gi|15673248|ref|NP_267422.1| UDP-N-acetylglucosamine 2-epimerase 746361003472 potential frameshift: common BLAST hit: gi|281491786|ref|YP_003353766.1| UDP-N-acetylglucosamine 2-epimerase 746361003473 potential frameshift: common BLAST hit: gi|15673247|ref|NP_267421.1| glycosyl transferase 746361003474 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 746361003475 substrate binding site [chemical binding]; other site 746361003476 multimerization interface [polypeptide binding]; other site 746361003477 ATP binding site [chemical binding]; other site 746361003478 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 746361003479 substrate binding site [chemical binding]; other site 746361003480 dimer interface [polypeptide binding]; other site 746361003481 ATP binding site [chemical binding]; other site 746361003482 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 746361003483 thiamine phosphate binding site [chemical binding]; other site 746361003484 active site 746361003485 pyrophosphate binding site [ion binding]; other site 746361003486 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 746361003487 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 746361003488 acyl-activating enzyme (AAE) consensus motif; other site 746361003489 AMP binding site [chemical binding]; other site 746361003490 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 746361003491 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 746361003492 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 746361003493 DltD N-terminal region; Region: DltD_N; pfam04915 746361003494 DltD central region; Region: DltD_M; pfam04918 746361003495 DltD C-terminal region; Region: DltD_C; pfam04914 746361003496 magnesium-transporting ATPase; Provisional; Region: PRK15122 746361003497 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 746361003498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361003499 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 746361003500 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 746361003501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746361003502 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 746361003503 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 746361003504 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 746361003505 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 746361003506 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 746361003507 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 746361003508 THF binding site; other site 746361003509 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 746361003510 substrate binding site [chemical binding]; other site 746361003511 THF binding site; other site 746361003512 zinc-binding site [ion binding]; other site 746361003513 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 746361003514 FAD binding site [chemical binding]; other site 746361003515 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 746361003516 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 746361003517 putative transposase OrfB; Reviewed; Region: PHA02517 746361003518 HTH-like domain; Region: HTH_21; pfam13276 746361003519 Integrase core domain; Region: rve; pfam00665 746361003520 Integrase core domain; Region: rve_2; pfam13333 746361003521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003522 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361003523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003524 Transposase; Region: HTH_Tnp_1; cl17663 746361003525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003526 Transposase; Region: HTH_Tnp_1; pfam01527 746361003527 putative transposase OrfB; Reviewed; Region: PHA02517 746361003528 HTH-like domain; Region: HTH_21; pfam13276 746361003529 Integrase core domain; Region: rve; pfam00665 746361003530 Integrase core domain; Region: rve_3; pfam13683 746361003531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003532 Transposase; Region: HTH_Tnp_1; pfam01527 746361003533 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746361003534 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746361003535 ligand binding site [chemical binding]; other site 746361003536 flexible hinge region; other site 746361003537 Predicted membrane protein [Function unknown]; Region: COG2364 746361003538 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 746361003539 NAD binding site [chemical binding]; other site 746361003540 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361003541 DNA-binding site [nucleotide binding]; DNA binding site 746361003542 RNA-binding motif; other site 746361003543 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361003544 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361003545 DNA binding site [nucleotide binding] 746361003546 domain linker motif; other site 746361003547 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 746361003548 dimerization interface [polypeptide binding]; other site 746361003549 ligand binding site [chemical binding]; other site 746361003550 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 746361003551 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 746361003552 dimer interface [polypeptide binding]; other site 746361003553 active site 746361003554 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 746361003555 dimer interface [polypeptide binding]; other site 746361003556 active site 746361003557 potential frameshift: common BLAST hit: gi|226222677|ref|YP_002756784.1| xylose repressor and to glucokinase 746361003558 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 746361003559 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 746361003560 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 746361003561 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361003562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361003563 active site 746361003564 motif I; other site 746361003565 motif II; other site 746361003566 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361003567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361003568 dimerization interface [polypeptide binding]; other site 746361003569 putative DNA binding site [nucleotide binding]; other site 746361003570 putative Zn2+ binding site [ion binding]; other site 746361003571 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 746361003572 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 746361003573 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 746361003574 P loop; other site 746361003575 Nucleotide binding site [chemical binding]; other site 746361003576 DTAP/Switch II; other site 746361003577 Switch I; other site 746361003578 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 746361003579 P loop; other site 746361003580 Nucleotide binding site [chemical binding]; other site 746361003581 DTAP/Switch II; other site 746361003582 Switch I; other site 746361003583 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 746361003584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361003585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361003586 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361003587 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 746361003588 active site residue [active] 746361003589 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 746361003590 arsenical-resistance protein; Region: acr3; TIGR00832 746361003591 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361003592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 746361003593 DNA binding residues [nucleotide binding] 746361003594 putative dimer interface [polypeptide binding]; other site 746361003595 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 746361003596 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 746361003597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746361003598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746361003599 active site 746361003600 catalytic tetrad [active] 746361003601 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361003602 DNA-binding site [nucleotide binding]; DNA binding site 746361003603 RNA-binding motif; other site 746361003604 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361003605 DNA-binding site [nucleotide binding]; DNA binding site 746361003606 RNA-binding motif; other site 746361003607 Predicted membrane protein [Function unknown]; Region: COG2261 746361003608 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 746361003609 Asp23 family; Region: Asp23; cl00574 746361003610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361003611 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361003612 Walker A motif; other site 746361003613 ATP binding site [chemical binding]; other site 746361003614 Walker B motif; other site 746361003615 arginine finger; other site 746361003616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361003617 Integrase core domain; Region: rve; pfam00665 746361003618 Asp23 family; Region: Asp23; cl00574 746361003619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003620 Transposase; Region: HTH_Tnp_1; pfam01527 746361003621 HTH-like domain; Region: HTH_21; pfam13276 746361003622 Integrase core domain; Region: rve; pfam00665 746361003623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361003624 Integrase core domain; Region: rve; pfam00665 746361003625 Integrase core domain; Region: rve_3; pfam13683 746361003626 Transposase; Region: HTH_Tnp_1; pfam01527 746361003627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003628 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 746361003629 oligomer interface [polypeptide binding]; other site 746361003630 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 746361003631 NAD binding site [chemical binding]; other site 746361003632 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 746361003633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361003634 active site 746361003635 DNA binding site [nucleotide binding] 746361003636 Int/Topo IB signature motif; other site 746361003637 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 746361003638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361003639 active site 746361003640 DNA binding site [nucleotide binding] 746361003641 Int/Topo IB signature motif; other site 746361003642 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 746361003643 Glucose inhibited division protein A; Region: GIDA; pfam01134 746361003644 DNA topoisomerase I; Validated; Region: PRK05582 746361003645 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 746361003646 active site 746361003647 interdomain interaction site; other site 746361003648 putative metal-binding site [ion binding]; other site 746361003649 nucleotide binding site [chemical binding]; other site 746361003650 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 746361003651 domain I; other site 746361003652 DNA binding groove [nucleotide binding] 746361003653 phosphate binding site [ion binding]; other site 746361003654 domain II; other site 746361003655 domain III; other site 746361003656 nucleotide binding site [chemical binding]; other site 746361003657 catalytic site [active] 746361003658 domain IV; other site 746361003659 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 746361003660 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 746361003661 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 746361003662 DNA protecting protein DprA; Region: dprA; TIGR00732 746361003663 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 746361003664 homotrimer interaction site [polypeptide binding]; other site 746361003665 putative active site [active] 746361003666 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 746361003667 threonine dehydratase; Validated; Region: PRK08639 746361003668 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 746361003669 tetramer interface [polypeptide binding]; other site 746361003670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361003671 catalytic residue [active] 746361003672 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 746361003673 ketol-acid reductoisomerase; Provisional; Region: PRK05479 746361003674 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 746361003675 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 746361003676 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 746361003677 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 746361003678 putative valine binding site [chemical binding]; other site 746361003679 dimer interface [polypeptide binding]; other site 746361003680 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 746361003681 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 746361003682 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 746361003683 PYR/PP interface [polypeptide binding]; other site 746361003684 dimer interface [polypeptide binding]; other site 746361003685 TPP binding site [chemical binding]; other site 746361003686 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 746361003687 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 746361003688 TPP-binding site [chemical binding]; other site 746361003689 dimer interface [polypeptide binding]; other site 746361003690 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 746361003691 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 746361003692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 746361003693 Walker A/P-loop; other site 746361003694 ATP binding site [chemical binding]; other site 746361003695 Q-loop/lid; other site 746361003696 ABC transporter signature motif; other site 746361003697 Walker B; other site 746361003698 D-loop; other site 746361003699 H-loop/switch region; other site 746361003700 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 746361003701 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 746361003702 substrate binding site [chemical binding]; other site 746361003703 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 746361003704 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 746361003705 substrate binding site [chemical binding]; other site 746361003706 ligand binding site [chemical binding]; other site 746361003707 potential frameshift: common BLAST hit: gi|281491722|ref|YP_003353702.1| 3-isopropylmalate dehydrogenase 746361003708 potential frameshift: common BLAST hit: gi|116512053|ref|YP_809269.1| 2-isopropylmalate synthase 746361003709 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 746361003710 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 746361003711 active site residue [active] 746361003712 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 746361003713 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 746361003714 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 746361003715 active site 746361003716 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 746361003717 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 746361003718 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 746361003719 metal binding site [ion binding]; metal-binding site 746361003720 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 746361003721 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 746361003722 substrate binding site [chemical binding]; other site 746361003723 glutamase interaction surface [polypeptide binding]; other site 746361003724 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 746361003725 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 746361003726 catalytic residues [active] 746361003727 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 746361003728 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 746361003729 putative active site [active] 746361003730 oxyanion strand; other site 746361003731 catalytic triad [active] 746361003732 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 746361003733 active site 746361003734 ATP binding site [chemical binding]; other site 746361003735 Phosphotransferase enzyme family; Region: APH; pfam01636 746361003736 antibiotic binding site [chemical binding]; other site 746361003737 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 746361003738 putative active site pocket [active] 746361003739 4-fold oligomerization interface [polypeptide binding]; other site 746361003740 metal binding residues [ion binding]; metal-binding site 746361003741 3-fold/trimer interface [polypeptide binding]; other site 746361003742 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 746361003743 histidinol dehydrogenase; Region: hisD; TIGR00069 746361003744 NAD binding site [chemical binding]; other site 746361003745 dimerization interface [polypeptide binding]; other site 746361003746 product binding site; other site 746361003747 substrate binding site [chemical binding]; other site 746361003748 zinc binding site [ion binding]; other site 746361003749 catalytic residues [active] 746361003750 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 746361003751 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 746361003752 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 746361003753 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 746361003754 dimer interface [polypeptide binding]; other site 746361003755 motif 1; other site 746361003756 active site 746361003757 motif 2; other site 746361003758 motif 3; other site 746361003759 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 746361003760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361003761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361003762 homodimer interface [polypeptide binding]; other site 746361003763 catalytic residue [active] 746361003764 potential frameshift: common BLAST hit: gi|116512066|ref|YP_809282.1| steroid 5-alpha reductase family protein 746361003765 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 746361003766 DAK2 domain; Region: Dak2; pfam02734 746361003767 EDD domain protein, DegV family; Region: DegV; TIGR00762 746361003768 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 746361003769 Predicted membrane protein [Function unknown]; Region: COG4852 746361003770 TspO/MBR family; Region: TspO_MBR; pfam03073 746361003771 ribonuclease R; Region: RNase_R; TIGR02063 746361003772 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 746361003773 RNB domain; Region: RNB; pfam00773 746361003774 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 746361003775 RNA binding site [nucleotide binding]; other site 746361003776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361003777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003778 non-specific DNA binding site [nucleotide binding]; other site 746361003779 salt bridge; other site 746361003780 sequence-specific DNA binding site [nucleotide binding]; other site 746361003781 legume lectins; Region: lectin_L-type; cl14058 746361003782 carbohydrate binding site [chemical binding]; other site 746361003783 metal binding site [ion binding]; metal-binding site 746361003784 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 746361003785 domain interaction interfaces [polypeptide binding]; other site 746361003786 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 746361003787 domain interaction interfaces [polypeptide binding]; other site 746361003788 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 746361003789 domain interaction interfaces [polypeptide binding]; other site 746361003790 acetolactate synthase; Reviewed; Region: PRK08617 746361003791 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 746361003792 PYR/PP interface [polypeptide binding]; other site 746361003793 dimer interface [polypeptide binding]; other site 746361003794 TPP binding site [chemical binding]; other site 746361003795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 746361003796 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 746361003797 TPP-binding site [chemical binding]; other site 746361003798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746361003799 binding surface 746361003800 TPR motif; other site 746361003801 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746361003802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746361003803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746361003804 binding surface 746361003805 TPR motif; other site 746361003806 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 746361003807 Domain of unknown function DUF20; Region: UPF0118; pfam01594 746361003808 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746361003809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361003810 S-adenosylmethionine binding site [chemical binding]; other site 746361003811 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 746361003812 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 746361003813 TRAM domain; Region: TRAM; cl01282 746361003814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361003815 S-adenosylmethionine binding site [chemical binding]; other site 746361003816 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361003817 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361003818 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361003819 putative active site [active] 746361003820 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 746361003821 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 746361003822 putative active site cavity [active] 746361003823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 746361003824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361003825 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 746361003826 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361003827 MULE transposase domain; Region: MULE; pfam10551 746361003828 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 746361003829 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 746361003830 active site 746361003831 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 746361003832 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 746361003833 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 746361003834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361003835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361003836 putative substrate translocation pore; other site 746361003837 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 746361003838 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361003839 MULE transposase domain; Region: MULE; pfam10551 746361003840 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746361003841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746361003842 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 746361003843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 746361003844 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 746361003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361003846 dimer interface [polypeptide binding]; other site 746361003847 conserved gate region; other site 746361003848 putative PBP binding loops; other site 746361003849 ABC-ATPase subunit interface; other site 746361003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361003851 dimer interface [polypeptide binding]; other site 746361003852 conserved gate region; other site 746361003853 putative PBP binding loops; other site 746361003854 ABC-ATPase subunit interface; other site 746361003855 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 746361003856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361003857 Walker A/P-loop; other site 746361003858 ATP binding site [chemical binding]; other site 746361003859 Q-loop/lid; other site 746361003860 ABC transporter signature motif; other site 746361003861 Walker B; other site 746361003862 D-loop; other site 746361003863 H-loop/switch region; other site 746361003864 TOBE domain; Region: TOBE_2; pfam08402 746361003865 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 746361003866 FAD binding domain; Region: FAD_binding_4; pfam01565 746361003867 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 746361003868 homoserine kinase; Provisional; Region: PRK01212 746361003869 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 746361003870 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 746361003871 homoserine dehydrogenase; Provisional; Region: PRK06349 746361003872 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 746361003873 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 746361003874 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 746361003875 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 746361003876 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 746361003877 Substrate-binding site [chemical binding]; other site 746361003878 Substrate specificity [chemical binding]; other site 746361003879 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 746361003880 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361003881 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746361003882 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 746361003883 nudix motif; other site 746361003884 dihydropteroate synthase; Region: DHPS; TIGR01496 746361003885 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 746361003886 substrate binding pocket [chemical binding]; other site 746361003887 dimer interface [polypeptide binding]; other site 746361003888 inhibitor binding site; inhibition site 746361003889 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 746361003890 catalytic center binding site [active] 746361003891 ATP binding site [chemical binding]; other site 746361003892 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 746361003893 GTP cyclohydrolase I; Provisional; Region: PLN03044 746361003894 active site 746361003895 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 746361003896 active site 746361003897 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 746361003898 G1 box; other site 746361003899 GTP/Mg2+ binding site [chemical binding]; other site 746361003900 Switch I region; other site 746361003901 G2 box; other site 746361003902 G3 box; other site 746361003903 Switch II region; other site 746361003904 G4 box; other site 746361003905 G5 box; other site 746361003906 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 746361003907 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 746361003908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361003909 Walker A motif; other site 746361003910 ATP binding site [chemical binding]; other site 746361003911 Walker B motif; other site 746361003912 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 746361003913 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 746361003914 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 746361003915 folate binding site [chemical binding]; other site 746361003916 NADP+ binding site [chemical binding]; other site 746361003917 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 746361003918 xanthine permease; Region: pbuX; TIGR03173 746361003919 Sulfate transporter family; Region: Sulfate_transp; pfam00916 746361003920 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361003921 active site 746361003922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003923 non-specific DNA binding site [nucleotide binding]; other site 746361003924 salt bridge; other site 746361003925 sequence-specific DNA binding site [nucleotide binding]; other site 746361003926 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 746361003927 hypothetical protein; Provisional; Region: PRK14013 746361003928 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 746361003929 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 746361003930 putative metal binding site [ion binding]; other site 746361003931 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 746361003932 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 746361003933 putative metal binding site [ion binding]; other site 746361003934 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 746361003935 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 746361003936 putative metal binding site [ion binding]; other site 746361003937 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 746361003938 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 746361003939 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 746361003940 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 746361003941 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 746361003942 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 746361003943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361003944 non-specific DNA binding site [nucleotide binding]; other site 746361003945 salt bridge; other site 746361003946 sequence-specific DNA binding site [nucleotide binding]; other site 746361003947 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 746361003948 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 746361003949 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 746361003950 active site 746361003951 catalytic residues [active] 746361003952 DNA binding site [nucleotide binding] 746361003953 Int/Topo IB signature motif; other site 746361003954 putative transposase OrfB; Reviewed; Region: PHA02517 746361003955 HTH-like domain; Region: HTH_21; pfam13276 746361003956 Integrase core domain; Region: rve; pfam00665 746361003957 Integrase core domain; Region: rve_3; pfam13683 746361003958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361003959 Transposase; Region: HTH_Tnp_1; pfam01527 746361003960 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 746361003961 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 746361003962 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 746361003963 putative active site [active] 746361003964 putative NTP binding site [chemical binding]; other site 746361003965 putative nucleic acid binding site [nucleotide binding]; other site 746361003966 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 746361003967 Type II intron maturase; Region: Intron_maturas2; pfam01348 746361003968 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 746361003969 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 746361003970 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 746361003971 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 746361003972 Toprim-like; Region: Toprim_2; pfam13155 746361003973 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 746361003974 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 746361003975 CHAP domain; Region: CHAP; pfam05257 746361003976 Domain of unknown function DUF87; Region: DUF87; pfam01935 746361003977 AAA-like domain; Region: AAA_10; pfam12846 746361003978 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 746361003979 Glucan-binding protein C; Region: GbpC; pfam08363 746361003980 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 746361003981 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 746361003982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746361003983 HSP70 interaction site [polypeptide binding]; other site 746361003984 AAA domain; Region: AAA_31; pfam13614 746361003985 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 746361003986 P-loop; other site 746361003987 Magnesium ion binding site [ion binding]; other site 746361003988 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 746361003989 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 746361003990 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 746361003991 active site 746361003992 Predicted membrane protein [Function unknown]; Region: COG4478 746361003993 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 746361003994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361003995 active site 746361003996 motif I; other site 746361003997 motif II; other site 746361003998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361003999 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 746361004000 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 746361004001 active site 746361004002 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 746361004003 active site 2 [active] 746361004004 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 746361004005 catalytic motif [active] 746361004006 Zn binding site [ion binding]; other site 746361004007 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 746361004008 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 746361004009 active site 746361004010 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 746361004011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361004012 FeS/SAM binding site; other site 746361004013 HemN C-terminal domain; Region: HemN_C; pfam06969 746361004014 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 746361004015 ParB-like nuclease domain; Region: ParB; smart00470 746361004016 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 746361004017 Active Sites [active] 746361004018 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 746361004019 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 746361004020 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 746361004021 active site 746361004022 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 746361004023 triosephosphate isomerase; Provisional; Region: PRK14565 746361004024 substrate binding site [chemical binding]; other site 746361004025 dimer interface [polypeptide binding]; other site 746361004026 catalytic triad [active] 746361004027 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361004028 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361004029 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361004030 putative active site [active] 746361004031 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 746361004032 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 746361004033 active site turn [active] 746361004034 phosphorylation site [posttranslational modification] 746361004035 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 746361004036 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 746361004037 HPr interaction site; other site 746361004038 glycerol kinase (GK) interaction site [polypeptide binding]; other site 746361004039 active site 746361004040 phosphorylation site [posttranslational modification] 746361004041 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 746361004042 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 746361004043 putative active site [active] 746361004044 Uncharacterized conserved protein [Function unknown]; Region: COG3589 746361004045 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 746361004046 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 746361004047 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 746361004048 dimer interface [polypeptide binding]; other site 746361004049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361004050 NAD binding site [chemical binding]; other site 746361004051 substrate binding site [chemical binding]; other site 746361004052 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 746361004053 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 746361004054 active site 746361004055 Riboflavin kinase; Region: Flavokinase; smart00904 746361004056 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 746361004057 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 746361004058 RNA binding site [nucleotide binding]; other site 746361004059 active site 746361004060 potential frameshift: common BLAST hit: gi|385838204|ref|YP_005875834.1| cell surface protein 746361004061 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 746361004062 putative transposase OrfB; Reviewed; Region: PHA02517 746361004063 HTH-like domain; Region: HTH_21; pfam13276 746361004064 Integrase core domain; Region: rve; pfam00665 746361004065 Integrase core domain; Region: rve_3; pfam13683 746361004066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004067 Transposase; Region: HTH_Tnp_1; pfam01527 746361004068 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 746361004069 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 746361004070 L-aspartate oxidase; Provisional; Region: PRK06175 746361004071 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 746361004072 dimer interface [polypeptide binding]; other site 746361004073 potential frameshift: common BLAST hit: gi|116511960|ref|YP_809176.1| DNA-3-methyladenine glycosylase I 746361004074 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 746361004075 putative active site [active] 746361004076 nucleotide binding site [chemical binding]; other site 746361004077 nudix motif; other site 746361004078 putative metal binding site [ion binding]; other site 746361004079 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 746361004080 Part of AAA domain; Region: AAA_19; pfam13245 746361004081 Family description; Region: UvrD_C_2; pfam13538 746361004082 Protein of unknown function (DUF998); Region: DUF998; pfam06197 746361004083 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 746361004084 Uncharacterized conserved protein [Function unknown]; Region: COG2898 746361004085 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 746361004086 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 746361004087 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 746361004088 dimer interface [polypeptide binding]; other site 746361004089 putative anticodon binding site; other site 746361004090 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 746361004091 active site 746361004092 catalytic site [active] 746361004093 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 746361004094 ApbE family; Region: ApbE; pfam02424 746361004095 DNA gyrase subunit A; Validated; Region: PRK05560 746361004096 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 746361004097 CAP-like domain; other site 746361004098 active site 746361004099 primary dimer interface [polypeptide binding]; other site 746361004100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004106 Amino acid permease; Region: AA_permease_2; pfam13520 746361004107 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 746361004108 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746361004109 NAD(P) binding site [chemical binding]; other site 746361004110 putative active site [active] 746361004111 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 746361004112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361004113 nucleotide binding site [chemical binding]; other site 746361004114 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 746361004115 beta-galactosidase; Region: BGL; TIGR03356 746361004116 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 746361004117 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 746361004118 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 746361004119 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 746361004120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361004121 Walker A/P-loop; other site 746361004122 ATP binding site [chemical binding]; other site 746361004123 Q-loop/lid; other site 746361004124 ABC transporter signature motif; other site 746361004125 Walker B; other site 746361004126 D-loop; other site 746361004127 H-loop/switch region; other site 746361004128 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746361004129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 746361004130 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 746361004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361004132 dimer interface [polypeptide binding]; other site 746361004133 conserved gate region; other site 746361004134 putative PBP binding loops; other site 746361004135 ABC-ATPase subunit interface; other site 746361004136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 746361004137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361004138 dimer interface [polypeptide binding]; other site 746361004139 conserved gate region; other site 746361004140 putative PBP binding loops; other site 746361004141 ABC-ATPase subunit interface; other site 746361004142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 746361004143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746361004144 Walker A/P-loop; other site 746361004145 ATP binding site [chemical binding]; other site 746361004146 Q-loop/lid; other site 746361004147 ABC transporter signature motif; other site 746361004148 Walker B; other site 746361004149 D-loop; other site 746361004150 H-loop/switch region; other site 746361004151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746361004152 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 746361004153 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 746361004154 substrate binding site [chemical binding]; other site 746361004155 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361004156 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361004157 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361004158 putative active site [active] 746361004159 GTP-binding protein LepA; Provisional; Region: PRK05433 746361004160 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 746361004161 G1 box; other site 746361004162 putative GEF interaction site [polypeptide binding]; other site 746361004163 GTP/Mg2+ binding site [chemical binding]; other site 746361004164 Switch I region; other site 746361004165 G2 box; other site 746361004166 G3 box; other site 746361004167 Switch II region; other site 746361004168 G4 box; other site 746361004169 G5 box; other site 746361004170 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 746361004171 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 746361004172 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 746361004173 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 746361004174 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 746361004175 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361004176 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 746361004177 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 746361004178 catalytic triad [active] 746361004179 FtsX-like permease family; Region: FtsX; pfam02687 746361004180 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746361004181 FtsX-like permease family; Region: FtsX; pfam02687 746361004182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361004183 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361004184 Walker A/P-loop; other site 746361004185 ATP binding site [chemical binding]; other site 746361004186 Q-loop/lid; other site 746361004187 ABC transporter signature motif; other site 746361004188 Walker B; other site 746361004189 D-loop; other site 746361004190 H-loop/switch region; other site 746361004191 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 746361004192 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 746361004193 homodimer interface [polypeptide binding]; other site 746361004194 NAD binding pocket [chemical binding]; other site 746361004195 ATP binding pocket [chemical binding]; other site 746361004196 Mg binding site [ion binding]; other site 746361004197 active-site loop [active] 746361004198 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 746361004199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361004200 Coenzyme A binding pocket [chemical binding]; other site 746361004201 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 746361004202 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 746361004203 active site 746361004204 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 746361004205 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 746361004206 active site 746361004207 (T/H)XGH motif; other site 746361004208 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 746361004209 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 746361004210 putative Cl- selectivity filter; other site 746361004211 putative pore gating glutamate residue; other site 746361004212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 746361004213 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 746361004214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 746361004215 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 746361004216 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 746361004217 motif 1; other site 746361004218 dimer interface [polypeptide binding]; other site 746361004219 active site 746361004220 motif 2; other site 746361004221 motif 3; other site 746361004222 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 746361004223 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 746361004224 active site 746361004225 metal binding site [ion binding]; metal-binding site 746361004226 hypothetical protein; Provisional; Region: PRK14013 746361004227 VanZ like family; Region: VanZ; pfam04892 746361004228 Uncharacterized conserved protein [Function unknown]; Region: COG1739 746361004229 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 746361004230 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 746361004231 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 746361004232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 746361004233 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 746361004234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 746361004235 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 746361004236 metal-binding heat shock protein; Provisional; Region: PRK00016 746361004237 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 746361004238 nudix motif; other site 746361004239 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 746361004240 PhoH-like protein; Region: PhoH; pfam02562 746361004241 manganese transport protein MntH; Reviewed; Region: PRK00701 746361004242 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 746361004243 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 746361004244 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 746361004245 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 746361004246 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 746361004247 Predicted membrane protein [Function unknown]; Region: COG3371 746361004248 Protein of unknown function (DUF998); Region: DUF998; pfam06197 746361004249 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 746361004250 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 746361004251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361004252 Zn2+ binding site [ion binding]; other site 746361004253 Mg2+ binding site [ion binding]; other site 746361004254 sugar phosphate phosphatase; Provisional; Region: PRK10513 746361004255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361004256 active site 746361004257 motif I; other site 746361004258 motif II; other site 746361004259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361004260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 746361004261 Uncharacterized conserved protein [Function unknown]; Region: COG0327 746361004262 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 746361004263 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 746361004264 Family of unknown function (DUF633); Region: DUF633; pfam04816 746361004265 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 746361004266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 746361004267 minor groove reading motif; other site 746361004268 helix-hairpin-helix signature motif; other site 746361004269 substrate binding pocket [chemical binding]; other site 746361004270 active site 746361004271 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 746361004272 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 746361004273 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 746361004274 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 746361004275 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 746361004276 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 746361004277 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 746361004278 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 746361004279 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 746361004280 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 746361004281 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 746361004282 active site 746361004283 active site 746361004284 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 746361004285 Helix-turn-helix domain; Region: HTH_38; pfam13936 746361004286 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 746361004287 Sel1-like repeats; Region: SEL1; smart00671 746361004288 Sel1 repeat; Region: Sel1; cl02723 746361004289 dihydroorotase; Validated; Region: pyrC; PRK09357 746361004290 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746361004291 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 746361004292 active site 746361004293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361004294 active site 746361004295 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746361004296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004298 ABC transporter; Region: ABC_tran_2; pfam12848 746361004299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004300 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 746361004301 ArsC family; Region: ArsC; pfam03960 746361004302 putative catalytic residues [active] 746361004303 thiol/disulfide switch; other site 746361004304 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 746361004305 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 746361004306 CoA binding domain; Region: CoA_binding; pfam02629 746361004307 DNA repair protein radc; Region: radc; TIGR00608 746361004308 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 746361004309 MPN+ (JAMM) motif; other site 746361004310 Zinc-binding site [ion binding]; other site 746361004311 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 746361004312 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 746361004313 glutaminase active site [active] 746361004314 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 746361004315 dimer interface [polypeptide binding]; other site 746361004316 active site 746361004317 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 746361004318 dimer interface [polypeptide binding]; other site 746361004319 active site 746361004320 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 746361004321 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 746361004322 active site 746361004323 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 746361004324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361004325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746361004326 dimer interface [polypeptide binding]; other site 746361004327 phosphorylation site [posttranslational modification] 746361004328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361004329 ATP binding site [chemical binding]; other site 746361004330 Mg2+ binding site [ion binding]; other site 746361004331 G-X-G motif; other site 746361004332 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 746361004333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361004334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361004335 active site 746361004336 phosphorylation site [posttranslational modification] 746361004337 intermolecular recognition site; other site 746361004338 dimerization interface [polypeptide binding]; other site 746361004339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361004340 DNA binding site [nucleotide binding] 746361004341 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 746361004342 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 746361004343 Ligand binding site; other site 746361004344 Putative Catalytic site; other site 746361004345 DXD motif; other site 746361004346 conserved hypothetical integral membrane protein; Region: TIGR03766 746361004347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 746361004348 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746361004349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361004350 RNA binding surface [nucleotide binding]; other site 746361004351 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746361004352 active site 746361004353 lipoprotein signal peptidase; Provisional; Region: PRK14797 746361004354 HTH domain; Region: HTH_11; pfam08279 746361004355 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 746361004356 homopentamer interface [polypeptide binding]; other site 746361004357 active site 746361004358 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 746361004359 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 746361004360 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 746361004361 dimerization interface [polypeptide binding]; other site 746361004362 active site 746361004363 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 746361004364 Lumazine binding domain; Region: Lum_binding; pfam00677 746361004365 Lumazine binding domain; Region: Lum_binding; pfam00677 746361004366 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 746361004367 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 746361004368 catalytic motif [active] 746361004369 Zn binding site [ion binding]; other site 746361004370 RibD C-terminal domain; Region: RibD_C; cl17279 746361004371 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 746361004372 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 746361004373 oligomer interface [polypeptide binding]; other site 746361004374 Cl binding site [ion binding]; other site 746361004375 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 746361004376 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 746361004377 CAP-like domain; other site 746361004378 active site 746361004379 primary dimer interface [polypeptide binding]; other site 746361004380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746361004382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361004383 Coenzyme A binding pocket [chemical binding]; other site 746361004384 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 746361004385 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746361004386 active site 746361004387 catalytic site [active] 746361004388 substrate binding site [chemical binding]; other site 746361004389 Isochorismatase family; Region: Isochorismatase; pfam00857 746361004390 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 746361004391 catalytic triad [active] 746361004392 conserved cis-peptide bond; other site 746361004393 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 746361004394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361004395 Mg2+ binding site [ion binding]; other site 746361004396 G-X-G motif; other site 746361004397 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 746361004398 anchoring element; other site 746361004399 dimer interface [polypeptide binding]; other site 746361004400 ATP binding site [chemical binding]; other site 746361004401 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 746361004402 active site 746361004403 putative metal-binding site [ion binding]; other site 746361004404 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 746361004405 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 746361004406 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 746361004407 catalytic residues [active] 746361004408 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 746361004409 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 746361004410 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 746361004411 Class I ribonucleotide reductase; Region: RNR_I; cd01679 746361004412 active site 746361004413 dimer interface [polypeptide binding]; other site 746361004414 catalytic residues [active] 746361004415 effector binding site; other site 746361004416 R2 peptide binding site; other site 746361004417 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 746361004418 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 746361004419 dimer interface [polypeptide binding]; other site 746361004420 putative radical transfer pathway; other site 746361004421 diiron center [ion binding]; other site 746361004422 tyrosyl radical; other site 746361004423 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 746361004424 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 746361004425 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 746361004426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361004427 Walker A/P-loop; other site 746361004428 ATP binding site [chemical binding]; other site 746361004429 Q-loop/lid; other site 746361004430 ABC transporter signature motif; other site 746361004431 Walker B; other site 746361004432 D-loop; other site 746361004433 H-loop/switch region; other site 746361004434 peptide chain release factor 2; Validated; Region: prfB; PRK00578 746361004435 This domain is found in peptide chain release factors; Region: PCRF; smart00937 746361004436 RF-1 domain; Region: RF-1; pfam00472 746361004437 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 746361004438 putative phosphoesterase; Region: acc_ester; TIGR03729 746361004439 hypothetical protein; Provisional; Region: PRK13662 746361004440 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 746361004441 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 746361004442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 746361004443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746361004444 Walker A/P-loop; other site 746361004445 ATP binding site [chemical binding]; other site 746361004446 Q-loop/lid; other site 746361004447 ABC transporter signature motif; other site 746361004448 Walker B; other site 746361004449 D-loop; other site 746361004450 H-loop/switch region; other site 746361004451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 746361004452 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 746361004453 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 746361004454 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 746361004455 dimer interface [polypeptide binding]; other site 746361004456 phosphate binding site [ion binding]; other site 746361004457 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 746361004458 AAA domain; Region: AAA_18; pfam13238 746361004459 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 746361004460 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 746361004461 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 746361004462 putative active site [active] 746361004463 catalytic site [active] 746361004464 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 746361004465 putative active site [active] 746361004466 catalytic site [active] 746361004467 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746361004468 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746361004469 ligand binding site [chemical binding]; other site 746361004470 flexible hinge region; other site 746361004471 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 746361004472 putative switch regulator; other site 746361004473 non-specific DNA interactions [nucleotide binding]; other site 746361004474 DNA binding site [nucleotide binding] 746361004475 sequence specific DNA binding site [nucleotide binding]; other site 746361004476 putative cAMP binding site [chemical binding]; other site 746361004477 Heavy-metal-associated domain; Region: HMA; pfam00403 746361004478 metal-binding site [ion binding] 746361004479 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 746361004480 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361004481 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746361004482 Protein of unknown function (DUF805); Region: DUF805; pfam05656 746361004483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004484 Transposase; Region: HTH_Tnp_1; pfam01527 746361004485 putative transposase OrfB; Reviewed; Region: PHA02517 746361004486 HTH-like domain; Region: HTH_21; pfam13276 746361004487 Integrase core domain; Region: rve; pfam00665 746361004488 Integrase core domain; Region: rve_3; pfam13683 746361004489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004490 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361004491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004492 Transposase; Region: HTH_Tnp_1; cl17663 746361004493 potential frameshift: common BLAST hit: gi|116513067|ref|YP_811974.1| transposase 746361004494 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 746361004495 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 746361004496 active site 746361004497 phosphorylation site [posttranslational modification] 746361004498 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 746361004499 active site 746361004500 P-loop; other site 746361004501 phosphorylation site [posttranslational modification] 746361004502 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 746361004503 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 746361004504 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 746361004505 putative substrate binding site [chemical binding]; other site 746361004506 putative ATP binding site [chemical binding]; other site 746361004507 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 746361004508 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 746361004509 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 746361004510 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 746361004511 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 746361004512 metal binding site [ion binding]; metal-binding site 746361004513 dimer interface [polypeptide binding]; other site 746361004514 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 746361004515 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 746361004516 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 746361004517 nucleotide binding site [chemical binding]; other site 746361004518 NEF interaction site [polypeptide binding]; other site 746361004519 SBD interface [polypeptide binding]; other site 746361004520 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 746361004521 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 746361004522 dimer interface [polypeptide binding]; other site 746361004523 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 746361004524 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 746361004525 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 746361004526 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 746361004527 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 746361004528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361004529 catalytic core [active] 746361004530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361004531 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 746361004532 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 746361004533 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 746361004534 UbiA prenyltransferase family; Region: UbiA; pfam01040 746361004535 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746361004536 putative catalytic site [active] 746361004537 putative metal binding site [ion binding]; other site 746361004538 putative phosphate binding site [ion binding]; other site 746361004539 Isochorismatase family; Region: Isochorismatase; pfam00857 746361004540 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 746361004541 catalytic triad [active] 746361004542 conserved cis-peptide bond; other site 746361004543 ribonuclease R; Region: RNase_R; TIGR02063 746361004544 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 746361004545 RNB domain; Region: RNB; pfam00773 746361004546 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 746361004547 RNA binding site [nucleotide binding]; other site 746361004548 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 746361004549 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 746361004550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361004551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361004552 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 746361004553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 746361004554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 746361004555 Walker A/P-loop; other site 746361004556 ATP binding site [chemical binding]; other site 746361004557 Q-loop/lid; other site 746361004558 ABC transporter signature motif; other site 746361004559 Walker B; other site 746361004560 D-loop; other site 746361004561 H-loop/switch region; other site 746361004562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361004563 dimer interface [polypeptide binding]; other site 746361004564 conserved gate region; other site 746361004565 putative PBP binding loops; other site 746361004566 ABC-ATPase subunit interface; other site 746361004567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 746361004568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746361004569 substrate binding pocket [chemical binding]; other site 746361004570 membrane-bound complex binding site; other site 746361004571 hinge residues; other site 746361004572 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 746361004573 NlpC/P60 family; Region: NLPC_P60; pfam00877 746361004574 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 746361004575 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 746361004576 Potassium binding sites [ion binding]; other site 746361004577 Cesium cation binding sites [ion binding]; other site 746361004578 hypothetical protein; Provisional; Region: PRK00967 746361004579 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 746361004580 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 746361004581 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 746361004582 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 746361004583 phosphopentomutase; Provisional; Region: PRK05362 746361004584 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 746361004585 Transcriptional regulator [Transcription]; Region: LytR; COG1316 746361004586 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 746361004587 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 746361004588 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 746361004589 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 746361004590 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746361004591 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 746361004592 active site 746361004593 nucleotide binding site [chemical binding]; other site 746361004594 HIGH motif; other site 746361004595 KMSKS motif; other site 746361004596 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 746361004597 putative substrate binding site [chemical binding]; other site 746361004598 active site 746361004599 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 746361004600 active site 746361004601 catalytic triad [active] 746361004602 oxyanion hole [active] 746361004603 potential frameshift: common BLAST hit: gi|281491423|ref|YP_003353403.1| UDP-galactopyranose mutase 746361004604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361004605 Integrase core domain; Region: rve; pfam00665 746361004606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361004607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361004608 Walker A motif; other site 746361004609 ATP binding site [chemical binding]; other site 746361004610 Walker B motif; other site 746361004611 arginine finger; other site 746361004612 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 746361004613 trimer interface [polypeptide binding]; other site 746361004614 CoA binding site [chemical binding]; other site 746361004615 active site 746361004616 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 746361004617 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 746361004618 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 746361004619 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 746361004620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746361004621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361004622 active site 746361004623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361004624 active site 746361004625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361004626 active site 746361004627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361004628 active site 746361004629 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 746361004630 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 746361004631 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 746361004632 Walker A/P-loop; other site 746361004633 ATP binding site [chemical binding]; other site 746361004634 Q-loop/lid; other site 746361004635 ABC transporter signature motif; other site 746361004636 Walker B; other site 746361004637 D-loop; other site 746361004638 H-loop/switch region; other site 746361004639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746361004640 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 746361004641 potential frameshift: common BLAST hit: gi|281491412|ref|YP_003353392.1| Multidrug resistance protein B, MF superfamily 746361004642 MarR family; Region: MarR_2; pfam12802 746361004643 MarR family; Region: MarR_2; cl17246 746361004644 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 746361004645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361004646 S-adenosylmethionine binding site [chemical binding]; other site 746361004647 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 746361004648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361004649 Mg2+ binding site [ion binding]; other site 746361004650 G-X-G motif; other site 746361004651 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 746361004652 anchoring element; other site 746361004653 dimer interface [polypeptide binding]; other site 746361004654 ATP binding site [chemical binding]; other site 746361004655 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 746361004656 active site 746361004657 putative metal-binding site [ion binding]; other site 746361004658 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 746361004659 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 746361004660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361004661 motif II; other site 746361004662 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 746361004663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 746361004664 putative metal binding site [ion binding]; other site 746361004665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 746361004666 active site 746361004667 metal binding site [ion binding]; metal-binding site 746361004668 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 746361004669 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746361004670 Walker A/P-loop; other site 746361004671 ATP binding site [chemical binding]; other site 746361004672 Q-loop/lid; other site 746361004673 ABC transporter signature motif; other site 746361004674 Walker B; other site 746361004675 D-loop; other site 746361004676 H-loop/switch region; other site 746361004677 EamA-like transporter family; Region: EamA; pfam00892 746361004678 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 746361004679 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 746361004680 malate dehydrogenase; Provisional; Region: PRK13529 746361004681 Malic enzyme, N-terminal domain; Region: malic; pfam00390 746361004682 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 746361004683 NAD(P) binding site [chemical binding]; other site 746361004684 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746361004685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004687 ABC transporter; Region: ABC_tran_2; pfam12848 746361004688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746361004689 acetoin reductase; Validated; Region: PRK08643 746361004690 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 746361004691 NAD binding site [chemical binding]; other site 746361004692 homotetramer interface [polypeptide binding]; other site 746361004693 homodimer interface [polypeptide binding]; other site 746361004694 active site 746361004695 substrate binding site [chemical binding]; other site 746361004696 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 746361004697 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 746361004698 putative NAD(P) binding site [chemical binding]; other site 746361004699 catalytic Zn binding site [ion binding]; other site 746361004700 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 746361004701 Uncharacterized conserved protein [Function unknown]; Region: COG0398 746361004702 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 746361004703 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 746361004704 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746361004705 RNA binding site [nucleotide binding]; other site 746361004706 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746361004707 active site 746361004708 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361004709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 746361004710 motif II; other site 746361004711 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361004712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746361004713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361004714 active site 746361004715 phosphorylation site [posttranslational modification] 746361004716 intermolecular recognition site; other site 746361004717 dimerization interface [polypeptide binding]; other site 746361004718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746361004719 DNA binding residues [nucleotide binding] 746361004720 dimerization interface [polypeptide binding]; other site 746361004721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361004722 Histidine kinase; Region: HisKA_3; pfam07730 746361004723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361004724 ATP binding site [chemical binding]; other site 746361004725 Mg2+ binding site [ion binding]; other site 746361004726 G-X-G motif; other site 746361004727 Predicted membrane protein [Function unknown]; Region: COG4758 746361004728 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 746361004729 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 746361004730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746361004731 putative metal binding site [ion binding]; other site 746361004732 CHAP domain; Region: CHAP; pfam05257 746361004733 Surface antigen [General function prediction only]; Region: COG3942 746361004734 putative transposase OrfB; Reviewed; Region: PHA02517 746361004735 HTH-like domain; Region: HTH_21; pfam13276 746361004736 Integrase core domain; Region: rve; pfam00665 746361004737 Integrase core domain; Region: rve_3; pfam13683 746361004738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004739 Transposase; Region: HTH_Tnp_1; pfam01527 746361004740 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 746361004741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361004742 active site 746361004743 DNA binding site [nucleotide binding] 746361004744 Int/Topo IB signature motif; other site 746361004745 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 746361004746 Predicted membrane protein [Function unknown]; Region: COG1511 746361004747 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 746361004748 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 746361004749 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 746361004750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361004751 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 746361004752 IHF - DNA interface [nucleotide binding]; other site 746361004753 IHF dimer interface [polypeptide binding]; other site 746361004754 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361004755 Ligand Binding Site [chemical binding]; other site 746361004756 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 746361004757 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 746361004758 N-glycosyltransferase; Provisional; Region: PRK11204 746361004759 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 746361004760 DXD motif; other site 746361004761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361004762 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 746361004763 Coenzyme A binding pocket [chemical binding]; other site 746361004764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361004765 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 746361004766 SnoaL-like domain; Region: SnoaL_3; pfam13474 746361004767 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 746361004768 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 746361004769 synthetase active site [active] 746361004770 NTP binding site [chemical binding]; other site 746361004771 metal binding site [ion binding]; metal-binding site 746361004772 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361004773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361004774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361004775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 746361004776 dimerization interface [polypeptide binding]; other site 746361004777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361004778 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361004779 Walker A/P-loop; other site 746361004780 ATP binding site [chemical binding]; other site 746361004781 Q-loop/lid; other site 746361004782 ABC transporter signature motif; other site 746361004783 Walker B; other site 746361004784 D-loop; other site 746361004785 H-loop/switch region; other site 746361004786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746361004787 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 746361004788 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 746361004789 Mg++ binding site [ion binding]; other site 746361004790 putative catalytic motif [active] 746361004791 putative substrate binding site [chemical binding]; other site 746361004792 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 746361004793 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 746361004794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 746361004795 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 746361004796 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 746361004797 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 746361004798 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 746361004799 MraW methylase family; Region: Methyltransf_5; pfam01795 746361004800 Protein of unknown function (DUF805); Region: DUF805; pfam05656 746361004801 Protein of unknown function (DUF805); Region: DUF805; cl01224 746361004802 Predicted membrane protein [Function unknown]; Region: COG3152 746361004803 Predicted integral membrane protein [Function unknown]; Region: COG3548 746361004804 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 746361004805 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 746361004806 Walker A/P-loop; other site 746361004807 ATP binding site [chemical binding]; other site 746361004808 Q-loop/lid; other site 746361004809 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 746361004810 ABC transporter signature motif; other site 746361004811 Walker B; other site 746361004812 D-loop; other site 746361004813 H-loop/switch region; other site 746361004814 Arginine repressor [Transcription]; Region: ArgR; COG1438 746361004815 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 746361004816 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 746361004817 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 746361004818 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361004819 RNA binding surface [nucleotide binding]; other site 746361004820 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 746361004821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746361004822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361004823 Coenzyme A binding pocket [chemical binding]; other site 746361004824 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 746361004825 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 746361004826 substrate binding pocket [chemical binding]; other site 746361004827 chain length determination region; other site 746361004828 substrate-Mg2+ binding site; other site 746361004829 catalytic residues [active] 746361004830 aspartate-rich region 1; other site 746361004831 active site lid residues [active] 746361004832 aspartate-rich region 2; other site 746361004833 potential frameshift: common BLAST hit: gi|116511679|ref|YP_808895.1| glycerate kinase 746361004834 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 746361004835 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 746361004836 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 746361004837 generic binding surface II; other site 746361004838 generic binding surface I; other site 746361004839 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 746361004840 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 746361004841 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 746361004842 homodimer interface [polypeptide binding]; other site 746361004843 NADP binding site [chemical binding]; other site 746361004844 substrate binding site [chemical binding]; other site 746361004845 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 746361004846 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361004847 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 746361004848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361004849 Integrase core domain; Region: rve; pfam00665 746361004850 Integrase core domain; Region: rve_3; pfam13683 746361004851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361004852 ABC-ATPase subunit interface; other site 746361004853 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 746361004854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 746361004855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361004856 Walker A/P-loop; other site 746361004857 ATP binding site [chemical binding]; other site 746361004858 Q-loop/lid; other site 746361004859 ABC transporter signature motif; other site 746361004860 Walker B; other site 746361004861 D-loop; other site 746361004862 H-loop/switch region; other site 746361004863 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 746361004864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361004865 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361004866 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 746361004867 ArsC family; Region: ArsC; pfam03960 746361004868 putative catalytic residues [active] 746361004869 thiol/disulfide switch; other site 746361004870 alanine racemase; Reviewed; Region: alr; PRK00053 746361004871 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 746361004872 active site 746361004873 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746361004874 dimer interface [polypeptide binding]; other site 746361004875 substrate binding site [chemical binding]; other site 746361004876 catalytic residues [active] 746361004877 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 746361004878 dipeptidase PepV; Region: dipeptidase; TIGR01886 746361004879 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 746361004880 active site 746361004881 metal binding site [ion binding]; metal-binding site 746361004882 potential frameshift: common BLAST hit: gi|116511661|ref|YP_808877.1| lipopolysaccharide biosynthesis glycosyltransferase 746361004883 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 746361004884 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 746361004885 Ligand binding site; other site 746361004886 metal-binding site 746361004887 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 746361004888 trimer interface [polypeptide binding]; other site 746361004889 active site 746361004890 substrate binding site [chemical binding]; other site 746361004891 CoA binding site [chemical binding]; other site 746361004892 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361004893 active site 746361004894 Integrase core domain; Region: rve; pfam00665 746361004895 DDE domain; Region: DDE_Tnp_IS240; pfam13610 746361004896 Integrase core domain; Region: rve_3; pfam13683 746361004897 putative transposase OrfB; Reviewed; Region: PHA02517 746361004898 HTH-like domain; Region: HTH_21; pfam13276 746361004899 Integrase core domain; Region: rve; pfam00665 746361004900 Integrase core domain; Region: rve_3; pfam13683 746361004901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004902 Transposase; Region: HTH_Tnp_1; pfam01527 746361004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361004904 Transposase; Region: HTH_Tnp_1; pfam01527 746361004905 putative transposase OrfB; Reviewed; Region: PHA02517 746361004906 HTH-like domain; Region: HTH_21; pfam13276 746361004907 Integrase core domain; Region: rve; pfam00665 746361004908 Integrase core domain; Region: rve_3; pfam13683 746361004909 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 746361004910 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 746361004911 minor groove reading motif; other site 746361004912 helix-hairpin-helix signature motif; other site 746361004913 substrate binding pocket [chemical binding]; other site 746361004914 active site 746361004915 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 746361004916 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 746361004917 DNA binding and oxoG recognition site [nucleotide binding] 746361004918 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 746361004919 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 746361004920 GIY-YIG motif/motif A; other site 746361004921 active site 746361004922 catalytic site [active] 746361004923 putative DNA binding site [nucleotide binding]; other site 746361004924 metal binding site [ion binding]; metal-binding site 746361004925 UvrB/uvrC motif; Region: UVR; pfam02151 746361004926 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 746361004927 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 746361004928 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 746361004929 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 746361004930 potential frameshift: common BLAST hit: gi|116511654|ref|YP_808870.1| Signal transduction histidine kinase 746361004931 potential frameshift: common BLAST hit: gi|116511653|ref|YP_808869.1| DNA-binding response regulator 746361004932 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 746361004933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361004934 DNA binding site [nucleotide binding] 746361004935 potential frameshift: common BLAST hit: gi|385838681|ref|YP_005876311.1| Phosphate regulon transcriptional regulatory protein PhoB 746361004936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361004937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361004938 active site 746361004939 phosphorylation site [posttranslational modification] 746361004940 intermolecular recognition site; other site 746361004941 Fibronectin-binding repeat; Region: SSURE; pfam11966 746361004942 Fibronectin-binding repeat; Region: SSURE; pfam11966 746361004943 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 746361004944 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 746361004945 RNA binding site [nucleotide binding]; other site 746361004946 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 746361004947 RNA binding site [nucleotide binding]; other site 746361004948 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 746361004949 RNA binding site [nucleotide binding]; other site 746361004950 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746361004951 RNA binding site [nucleotide binding]; other site 746361004952 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 746361004953 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 746361004954 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 746361004955 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 746361004956 nucleotide binding site/active site [active] 746361004957 HIT family signature motif; other site 746361004958 catalytic residue [active] 746361004959 Predicted membrane protein [Function unknown]; Region: COG4485 746361004960 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 746361004961 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 746361004962 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 746361004963 metal-binding site [ion binding] 746361004964 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361004965 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746361004966 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 746361004967 metal-binding site [ion binding] 746361004968 Predicted transcriptional regulator [Transcription]; Region: COG3682 746361004969 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 746361004970 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 746361004971 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 746361004972 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 746361004973 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 746361004974 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 746361004975 putative L-serine binding site [chemical binding]; other site 746361004976 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 746361004977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361004978 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 746361004979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746361004980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361004981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 746361004982 Lipase (class 2); Region: Lipase_2; pfam01674 746361004983 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 746361004984 beta-galactosidase; Region: BGL; TIGR03356 746361004985 potential frameshift: common BLAST hit: gi|281491312|ref|YP_003353292.1| PTS system, cellobiose-specific IIC component 746361004986 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361004987 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361004988 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361004989 putative active site [active] 746361004990 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 746361004991 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 746361004992 HIGH motif; other site 746361004993 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 746361004994 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746361004995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746361004996 active site 746361004997 KMSKS motif; other site 746361004998 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 746361004999 tRNA binding surface [nucleotide binding]; other site 746361005000 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 746361005001 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 746361005002 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 746361005003 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 746361005004 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 746361005005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361005006 active site 746361005007 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 746361005008 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 746361005009 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 746361005010 P loop; other site 746361005011 GTP binding site [chemical binding]; other site 746361005012 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 746361005013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005014 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361005015 active site 746361005016 motif I; other site 746361005017 motif II; other site 746361005018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005019 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 746361005020 YibE/F-like protein; Region: YibE_F; cl02259 746361005021 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 746361005022 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 746361005023 Sulfatase; Region: Sulfatase; cl17466 746361005024 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 746361005025 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 746361005026 Walker A/P-loop; other site 746361005027 ATP binding site [chemical binding]; other site 746361005028 Q-loop/lid; other site 746361005029 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 746361005030 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 746361005031 ABC transporter signature motif; other site 746361005032 Walker B; other site 746361005033 D-loop; other site 746361005034 H-loop/switch region; other site 746361005035 ribonuclease III; Reviewed; Region: rnc; PRK00102 746361005036 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 746361005037 dimerization interface [polypeptide binding]; other site 746361005038 active site 746361005039 metal binding site [ion binding]; metal-binding site 746361005040 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 746361005041 dsRNA binding site [nucleotide binding]; other site 746361005042 ornithine carbamoyltransferase; Validated; Region: PRK02102 746361005043 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 746361005044 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 746361005045 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 746361005046 feedback inhibition sensing region; other site 746361005047 homohexameric interface [polypeptide binding]; other site 746361005048 nucleotide binding site [chemical binding]; other site 746361005049 N-acetyl-L-glutamate binding site [chemical binding]; other site 746361005050 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 746361005051 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746361005052 inhibitor-cofactor binding pocket; inhibition site 746361005053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361005054 catalytic residue [active] 746361005055 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 746361005056 heterotetramer interface [polypeptide binding]; other site 746361005057 active site pocket [active] 746361005058 cleavage site 746361005059 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 746361005060 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 746361005061 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 746361005062 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746361005063 NAD binding site [chemical binding]; other site 746361005064 substrate binding site [chemical binding]; other site 746361005065 putative active site [active] 746361005066 Predicted membrane protein [Function unknown]; Region: COG4708 746361005067 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 746361005068 classical (c) SDRs; Region: SDR_c; cd05233 746361005069 NAD(P) binding site [chemical binding]; other site 746361005070 active site 746361005071 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 746361005072 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 746361005073 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 746361005074 active site 746361005075 HIGH motif; other site 746361005076 KMSKS motif; other site 746361005077 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 746361005078 tRNA binding surface [nucleotide binding]; other site 746361005079 anticodon binding site; other site 746361005080 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 746361005081 dimer interface [polypeptide binding]; other site 746361005082 putative tRNA-binding site [nucleotide binding]; other site 746361005083 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 746361005084 active site 746361005085 putative catalytic site [active] 746361005086 DNA binding site [nucleotide binding] 746361005087 putative phosphate binding site [ion binding]; other site 746361005088 metal binding site A [ion binding]; metal-binding site 746361005089 AP binding site [nucleotide binding]; other site 746361005090 metal binding site B [ion binding]; metal-binding site 746361005091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746361005092 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 746361005093 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 746361005094 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 746361005095 ArsC family; Region: ArsC; pfam03960 746361005096 putative ArsC-like catalytic residues; other site 746361005097 putative TRX-like catalytic residues [active] 746361005098 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 746361005099 putative homodimer interface [polypeptide binding]; other site 746361005100 putative homotetramer interface [polypeptide binding]; other site 746361005101 putative metal binding site [ion binding]; other site 746361005102 putative homodimer-homodimer interface [polypeptide binding]; other site 746361005103 putative allosteric switch controlling residues; other site 746361005104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746361005105 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 746361005106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361005107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361005108 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 746361005109 active site residue [active] 746361005110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746361005111 active site residue [active] 746361005112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746361005113 active site residue [active] 746361005114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 746361005115 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 746361005116 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 746361005117 dimer interface [polypeptide binding]; other site 746361005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361005119 catalytic residue [active] 746361005120 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 746361005121 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746361005122 homodimer interface [polypeptide binding]; other site 746361005123 substrate-cofactor binding pocket; other site 746361005124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361005125 catalytic residue [active] 746361005126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 746361005127 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 746361005128 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 746361005129 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 746361005130 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 746361005131 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746361005132 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746361005133 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 746361005134 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 746361005135 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 746361005136 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 746361005137 carboxyltransferase (CT) interaction site; other site 746361005138 biotinylation site [posttranslational modification]; other site 746361005139 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 746361005140 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 746361005141 dimer interface [polypeptide binding]; other site 746361005142 active site 746361005143 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 746361005144 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 746361005145 NAD(P) binding site [chemical binding]; other site 746361005146 homotetramer interface [polypeptide binding]; other site 746361005147 homodimer interface [polypeptide binding]; other site 746361005148 active site 746361005149 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 746361005150 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 746361005151 acyl carrier protein; Provisional; Region: acpP; PRK00982 746361005152 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 746361005153 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 746361005154 dimer interface [polypeptide binding]; other site 746361005155 active site 746361005156 CoA binding pocket [chemical binding]; other site 746361005157 MarR family; Region: MarR; pfam01047 746361005158 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 746361005159 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 746361005160 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 746361005161 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 746361005162 translation initiation factor IF-2; Region: IF-2; TIGR00487 746361005163 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 746361005164 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 746361005165 G1 box; other site 746361005166 putative GEF interaction site [polypeptide binding]; other site 746361005167 GTP/Mg2+ binding site [chemical binding]; other site 746361005168 Switch I region; other site 746361005169 G2 box; other site 746361005170 G3 box; other site 746361005171 Switch II region; other site 746361005172 G4 box; other site 746361005173 G5 box; other site 746361005174 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 746361005175 Translation-initiation factor 2; Region: IF-2; pfam11987 746361005176 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 746361005177 hypothetical protein; Provisional; Region: PRK07283 746361005178 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 746361005179 putative RNA binding cleft [nucleotide binding]; other site 746361005180 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 746361005181 NusA N-terminal domain; Region: NusA_N; pfam08529 746361005182 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 746361005183 RNA binding site [nucleotide binding]; other site 746361005184 homodimer interface [polypeptide binding]; other site 746361005185 NusA-like KH domain; Region: KH_5; pfam13184 746361005186 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 746361005187 G-X-X-G motif; other site 746361005188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 746361005189 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 746361005190 putative oligomer interface [polypeptide binding]; other site 746361005191 putative RNA binding site [nucleotide binding]; other site 746361005192 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 746361005193 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 746361005194 CD20-like family; Region: CD20; pfam04103 746361005195 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 746361005196 active site 746361005197 catalytic site [active] 746361005198 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 746361005199 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 746361005200 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361005201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361005202 non-specific DNA binding site [nucleotide binding]; other site 746361005203 salt bridge; other site 746361005204 sequence-specific DNA binding site [nucleotide binding]; other site 746361005205 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361005206 GTP-binding protein Der; Reviewed; Region: PRK00093 746361005207 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 746361005208 G1 box; other site 746361005209 GTP/Mg2+ binding site [chemical binding]; other site 746361005210 Switch I region; other site 746361005211 G2 box; other site 746361005212 Switch II region; other site 746361005213 G3 box; other site 746361005214 G4 box; other site 746361005215 G5 box; other site 746361005216 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 746361005217 G1 box; other site 746361005218 GTP/Mg2+ binding site [chemical binding]; other site 746361005219 Switch I region; other site 746361005220 G2 box; other site 746361005221 G3 box; other site 746361005222 Switch II region; other site 746361005223 G4 box; other site 746361005224 G5 box; other site 746361005225 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 746361005226 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 746361005227 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 746361005228 dimer interface [polypeptide binding]; other site 746361005229 FMN binding site [chemical binding]; other site 746361005230 NADPH bind site [chemical binding]; other site 746361005231 primosomal protein DnaI; Reviewed; Region: PRK08939 746361005232 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 746361005233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361005234 Walker A motif; other site 746361005235 ATP binding site [chemical binding]; other site 746361005236 Walker B motif; other site 746361005237 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 746361005238 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 746361005239 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 746361005240 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 746361005241 ATP cone domain; Region: ATP-cone; pfam03477 746361005242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361005243 S-adenosylmethionine binding site [chemical binding]; other site 746361005244 Phosphotransferase enzyme family; Region: APH; pfam01636 746361005245 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 746361005246 active site 746361005247 ATP binding site [chemical binding]; other site 746361005248 substrate binding site [chemical binding]; other site 746361005249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 746361005250 replicative DNA helicase; Provisional; Region: PRK05748 746361005251 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 746361005252 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 746361005253 Walker A motif; other site 746361005254 ATP binding site [chemical binding]; other site 746361005255 Walker B motif; other site 746361005256 DNA binding loops [nucleotide binding] 746361005257 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 746361005258 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 746361005259 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 746361005260 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 746361005261 DHH family; Region: DHH; pfam01368 746361005262 DHHA1 domain; Region: DHHA1; pfam02272 746361005263 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 746361005264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005265 motif II; other site 746361005266 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361005267 MarR family; Region: MarR_2; pfam12802 746361005268 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 746361005269 active site 746361005270 nucleophile elbow; other site 746361005271 aspartate kinase; Reviewed; Region: PRK09034 746361005272 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 746361005273 nucleotide binding site [chemical binding]; other site 746361005274 substrate binding site [chemical binding]; other site 746361005275 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 746361005276 allosteric regulatory residue; other site 746361005277 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 746361005278 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 746361005279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005280 active site 746361005281 motif I; other site 746361005282 motif II; other site 746361005283 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361005284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 746361005285 metal binding site [ion binding]; metal-binding site 746361005286 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 746361005287 active site 746361005288 homotetramer interface [polypeptide binding]; other site 746361005289 homodimer interface [polypeptide binding]; other site 746361005290 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 746361005291 DHH family; Region: DHH; pfam01368 746361005292 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 746361005293 DRTGG domain; Region: DRTGG; pfam07085 746361005294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 746361005295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746361005296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361005297 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 746361005298 chorismate binding enzyme; Region: Chorismate_bind; cl10555 746361005299 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 746361005300 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 746361005301 dimer interface [polypeptide binding]; other site 746361005302 tetramer interface [polypeptide binding]; other site 746361005303 PYR/PP interface [polypeptide binding]; other site 746361005304 TPP binding site [chemical binding]; other site 746361005305 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 746361005306 TPP-binding site; other site 746361005307 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 746361005308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746361005309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746361005310 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 746361005311 substrate binding site [chemical binding]; other site 746361005312 oxyanion hole (OAH) forming residues; other site 746361005313 trimer interface [polypeptide binding]; other site 746361005314 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 746361005315 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 746361005316 acyl-activating enzyme (AAE) consensus motif; other site 746361005317 putative AMP binding site [chemical binding]; other site 746361005318 putative active site [active] 746361005319 putative CoA binding site [chemical binding]; other site 746361005320 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 746361005321 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 746361005322 active site 746361005323 octamer interface [polypeptide binding]; other site 746361005324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 746361005325 CoenzymeA binding site [chemical binding]; other site 746361005326 subunit interaction site [polypeptide binding]; other site 746361005327 PHB binding site; other site 746361005328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 746361005329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 746361005330 DNA binding site [nucleotide binding] 746361005331 domain linker motif; other site 746361005332 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 746361005333 dimerization interface [polypeptide binding]; other site 746361005334 ligand binding site [chemical binding]; other site 746361005335 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 746361005336 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 746361005337 putative active site [active] 746361005338 putative catalytic site [active] 746361005339 Protein of unknown function, DUF624; Region: DUF624; pfam04854 746361005340 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 746361005341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 746361005342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 746361005343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005344 dimer interface [polypeptide binding]; other site 746361005345 conserved gate region; other site 746361005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 746361005347 ABC-ATPase subunit interface; other site 746361005348 putative transposase OrfB; Reviewed; Region: PHA02517 746361005349 HTH-like domain; Region: HTH_21; pfam13276 746361005350 Integrase core domain; Region: rve; pfam00665 746361005351 Integrase core domain; Region: rve_3; pfam13683 746361005352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005353 Transposase; Region: HTH_Tnp_1; pfam01527 746361005354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361005355 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 746361005356 nucleoside/Zn binding site; other site 746361005357 dimer interface [polypeptide binding]; other site 746361005358 catalytic motif [active] 746361005359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 746361005360 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 746361005361 active site 746361005362 metal binding site [ion binding]; metal-binding site 746361005363 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 746361005364 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361005365 DNA-binding site [nucleotide binding]; DNA binding site 746361005366 RNA-binding motif; other site 746361005367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746361005368 DNA-binding site [nucleotide binding]; DNA binding site 746361005369 RNA-binding motif; other site 746361005370 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 746361005371 substrate binding site [chemical binding]; other site 746361005372 THF binding site; other site 746361005373 zinc-binding site [ion binding]; other site 746361005374 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 746361005375 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 746361005376 putative NAD(P) binding site [chemical binding]; other site 746361005377 dimer interface [polypeptide binding]; other site 746361005378 Predicted membrane protein [Function unknown]; Region: COG3619 746361005379 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 746361005380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361005381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361005382 Walker A/P-loop; other site 746361005383 ATP binding site [chemical binding]; other site 746361005384 Q-loop/lid; other site 746361005385 ABC transporter signature motif; other site 746361005386 Walker B; other site 746361005387 D-loop; other site 746361005388 H-loop/switch region; other site 746361005389 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746361005390 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 746361005391 FtsX-like permease family; Region: FtsX; pfam02687 746361005392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 746361005393 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 746361005394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746361005395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361005396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361005397 Walker A/P-loop; other site 746361005398 ATP binding site [chemical binding]; other site 746361005399 Q-loop/lid; other site 746361005400 ABC transporter signature motif; other site 746361005401 Walker B; other site 746361005402 D-loop; other site 746361005403 H-loop/switch region; other site 746361005404 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 746361005405 catalytic triad [active] 746361005406 Flavodoxin domain; Region: Flavodoxin_5; cl17428 746361005407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361005408 putative DNA binding site [nucleotide binding]; other site 746361005409 putative Zn2+ binding site [ion binding]; other site 746361005410 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 746361005411 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 746361005412 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 746361005413 Walker A/P-loop; other site 746361005414 ATP binding site [chemical binding]; other site 746361005415 Q-loop/lid; other site 746361005416 ABC transporter signature motif; other site 746361005417 Walker B; other site 746361005418 D-loop; other site 746361005419 H-loop/switch region; other site 746361005420 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 746361005421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746361005422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361005423 Walker A/P-loop; other site 746361005424 ATP binding site [chemical binding]; other site 746361005425 Q-loop/lid; other site 746361005426 ABC transporter signature motif; other site 746361005427 Walker B; other site 746361005428 D-loop; other site 746361005429 H-loop/switch region; other site 746361005430 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 746361005431 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 746361005432 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 746361005433 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 746361005434 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 746361005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361005436 putative substrate translocation pore; other site 746361005437 POT family; Region: PTR2; pfam00854 746361005438 potential frameshift: common BLAST hit: gi|116511499|ref|YP_808715.1| metal-dependent membrane protease 746361005439 COMC family; Region: ComC; pfam03047 746361005440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361005441 non-specific DNA binding site [nucleotide binding]; other site 746361005442 salt bridge; other site 746361005443 sequence-specific DNA binding site [nucleotide binding]; other site 746361005444 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 746361005445 active site 746361005446 homodimer interface [polypeptide binding]; other site 746361005447 catalytic site [active] 746361005448 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 746361005449 homodimer interface [polypeptide binding]; other site 746361005450 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 746361005451 active site pocket [active] 746361005452 glycogen synthase; Provisional; Region: glgA; PRK00654 746361005453 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 746361005454 ADP-binding pocket [chemical binding]; other site 746361005455 homodimer interface [polypeptide binding]; other site 746361005456 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 746361005457 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 746361005458 ligand binding site; other site 746361005459 oligomer interface; other site 746361005460 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 746361005461 dimer interface [polypeptide binding]; other site 746361005462 N-terminal domain interface [polypeptide binding]; other site 746361005463 sulfate 1 binding site; other site 746361005464 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 746361005465 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 746361005466 ligand binding site; other site 746361005467 oligomer interface; other site 746361005468 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 746361005469 dimer interface [polypeptide binding]; other site 746361005470 N-terminal domain interface [polypeptide binding]; other site 746361005471 sulfate 1 binding site; other site 746361005472 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 746361005473 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361005474 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 746361005475 putative RNA binding site [nucleotide binding]; other site 746361005476 Transcription termination factor [Transcription]; Region: NusB; COG0781 746361005477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 746361005478 elongation factor P; Validated; Region: PRK00529 746361005479 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 746361005480 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 746361005481 RNA binding site [nucleotide binding]; other site 746361005482 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 746361005483 RNA binding site [nucleotide binding]; other site 746361005484 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 746361005485 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 746361005486 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 746361005487 active site 746361005488 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 746361005489 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 746361005490 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 746361005491 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 746361005492 putative active site [active] 746361005493 putative metal binding site [ion binding]; other site 746361005494 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 746361005495 topology modulation protein; Reviewed; Region: PRK08118 746361005496 AAA domain; Region: AAA_17; pfam13207 746361005497 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 746361005498 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 746361005499 active site 746361005500 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746361005501 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 746361005502 Int/Topo IB signature motif; other site 746361005503 Antirestriction protein (ArdA); Region: ArdA; pfam07275 746361005504 CHAP domain; Region: CHAP; cl17642 746361005505 Transposase; Region: HTH_Tnp_1; pfam01527 746361005506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005507 Integrase core domain; Region: rve; pfam00665 746361005508 DDE domain; Region: DDE_Tnp_IS240; pfam13610 746361005509 Integrase core domain; Region: rve_3; pfam13683 746361005510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005511 Transposase; Region: HTH_Tnp_1; pfam01527 746361005512 putative transposase OrfB; Reviewed; Region: PHA02517 746361005513 HTH-like domain; Region: HTH_21; pfam13276 746361005514 Integrase core domain; Region: rve; pfam00665 746361005515 Integrase core domain; Region: rve_3; pfam13683 746361005516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361005517 catalytic core [active] 746361005518 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 746361005519 PhoU domain; Region: PhoU; pfam01895 746361005520 PhoU domain; Region: PhoU; pfam01895 746361005521 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 746361005522 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 746361005523 Walker A/P-loop; other site 746361005524 ATP binding site [chemical binding]; other site 746361005525 Q-loop/lid; other site 746361005526 ABC transporter signature motif; other site 746361005527 Walker B; other site 746361005528 D-loop; other site 746361005529 H-loop/switch region; other site 746361005530 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 746361005531 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 746361005532 Walker A/P-loop; other site 746361005533 ATP binding site [chemical binding]; other site 746361005534 Q-loop/lid; other site 746361005535 ABC transporter signature motif; other site 746361005536 Walker B; other site 746361005537 D-loop; other site 746361005538 H-loop/switch region; other site 746361005539 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 746361005540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005541 dimer interface [polypeptide binding]; other site 746361005542 conserved gate region; other site 746361005543 putative PBP binding loops; other site 746361005544 ABC-ATPase subunit interface; other site 746361005545 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 746361005546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005547 dimer interface [polypeptide binding]; other site 746361005548 conserved gate region; other site 746361005549 putative PBP binding loops; other site 746361005550 ABC-ATPase subunit interface; other site 746361005551 PBP superfamily domain; Region: PBP_like_2; cl17296 746361005552 PBP superfamily domain; Region: PBP_like_2; cl17296 746361005553 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 746361005554 SmpB-tmRNA interface; other site 746361005555 Predicted transcriptional regulators [Transcription]; Region: COG1733 746361005556 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 746361005557 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 746361005558 dimer interface [polypeptide binding]; other site 746361005559 FMN binding site [chemical binding]; other site 746361005560 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 746361005561 active site 746361005562 catalytic triad [active] 746361005563 oxyanion hole [active] 746361005564 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 746361005565 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 746361005566 motif 1; other site 746361005567 active site 746361005568 motif 2; other site 746361005569 motif 3; other site 746361005570 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 746361005571 DHHA1 domain; Region: DHHA1; pfam02272 746361005572 foldase protein PrsA; Reviewed; Region: PRK12450 746361005573 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 746361005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361005575 S-adenosylmethionine binding site [chemical binding]; other site 746361005576 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 746361005577 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 746361005578 active site 746361005579 Zn binding site [ion binding]; other site 746361005580 Competence protein CoiA-like family; Region: CoiA; pfam06054 746361005581 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 746361005582 putative active site [active] 746361005583 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 746361005584 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 746361005585 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 746361005586 Sulfate transporter family; Region: Sulfate_transp; pfam00916 746361005587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005588 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361005589 active site 746361005590 motif I; other site 746361005591 motif II; other site 746361005592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 746361005593 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 746361005594 Cysteine-rich domain; Region: CCG; pfam02754 746361005595 Cysteine-rich domain; Region: CCG; pfam02754 746361005596 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 746361005597 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 746361005598 Uncharacterized conserved protein [Function unknown]; Region: COG1556 746361005599 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 746361005600 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 746361005601 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 746361005602 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 746361005603 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 746361005604 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361005605 Zn2+ binding site [ion binding]; other site 746361005606 Mg2+ binding site [ion binding]; other site 746361005607 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 746361005608 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 746361005609 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 746361005610 AAA domain; Region: AAA_30; pfam13604 746361005611 Family description; Region: UvrD_C_2; pfam13538 746361005612 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746361005613 catalytic core [active] 746361005614 prephenate dehydratase; Provisional; Region: PRK11898 746361005615 Prephenate dehydratase; Region: PDT; pfam00800 746361005616 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 746361005617 putative L-Phe binding site [chemical binding]; other site 746361005618 shikimate kinase; Reviewed; Region: aroK; PRK00131 746361005619 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 746361005620 ADP binding site [chemical binding]; other site 746361005621 magnesium binding site [ion binding]; other site 746361005622 putative shikimate binding site; other site 746361005623 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 746361005624 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 746361005625 hinge; other site 746361005626 active site 746361005627 prephenate dehydrogenase; Validated; Region: PRK06545 746361005628 prephenate dehydrogenase; Validated; Region: PRK08507 746361005629 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 746361005630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746361005631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361005632 ATP binding site [chemical binding]; other site 746361005633 Mg2+ binding site [ion binding]; other site 746361005634 G-X-G motif; other site 746361005635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746361005636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746361005637 active site 746361005638 phosphorylation site [posttranslational modification] 746361005639 intermolecular recognition site; other site 746361005640 dimerization interface [polypeptide binding]; other site 746361005641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746361005642 DNA binding site [nucleotide binding] 746361005643 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 746361005644 potential frameshift: common BLAST hit: gi|116512602|ref|YP_811509.1| peptide ABC transporter permease 746361005645 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361005646 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361005647 Walker A/P-loop; other site 746361005648 ATP binding site [chemical binding]; other site 746361005649 Q-loop/lid; other site 746361005650 ABC transporter signature motif; other site 746361005651 Walker B; other site 746361005652 D-loop; other site 746361005653 H-loop/switch region; other site 746361005654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 746361005655 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 746361005656 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 746361005657 Tetramer interface [polypeptide binding]; other site 746361005658 active site 746361005659 FMN-binding site [chemical binding]; other site 746361005660 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 746361005661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005662 motif II; other site 746361005663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 746361005664 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 746361005665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 746361005666 Protein of unknown function, DUF606; Region: DUF606; pfam04657 746361005667 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 746361005668 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 746361005669 active site 746361005670 dimer interface [polypeptide binding]; other site 746361005671 metal binding site [ion binding]; metal-binding site 746361005672 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 746361005673 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 746361005674 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 746361005675 shikimate binding site; other site 746361005676 NAD(P) binding site [chemical binding]; other site 746361005677 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 746361005678 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 746361005679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746361005680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 746361005681 substrate binding pocket [chemical binding]; other site 746361005682 membrane-bound complex binding site; other site 746361005683 hinge residues; other site 746361005684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746361005685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 746361005686 substrate binding pocket [chemical binding]; other site 746361005687 membrane-bound complex binding site; other site 746361005688 hinge residues; other site 746361005689 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 746361005690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005691 dimer interface [polypeptide binding]; other site 746361005692 conserved gate region; other site 746361005693 putative PBP binding loops; other site 746361005694 ABC-ATPase subunit interface; other site 746361005695 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 746361005696 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 746361005697 Walker A/P-loop; other site 746361005698 ATP binding site [chemical binding]; other site 746361005699 Q-loop/lid; other site 746361005700 ABC transporter signature motif; other site 746361005701 Walker B; other site 746361005702 D-loop; other site 746361005703 H-loop/switch region; other site 746361005704 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 746361005705 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 746361005706 gamma subunit interface [polypeptide binding]; other site 746361005707 epsilon subunit interface [polypeptide binding]; other site 746361005708 LBP interface [polypeptide binding]; other site 746361005709 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 746361005710 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 746361005711 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 746361005712 alpha subunit interaction interface [polypeptide binding]; other site 746361005713 Walker A motif; other site 746361005714 ATP binding site [chemical binding]; other site 746361005715 Walker B motif; other site 746361005716 inhibitor binding site; inhibition site 746361005717 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 746361005718 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 746361005719 core domain interface [polypeptide binding]; other site 746361005720 delta subunit interface [polypeptide binding]; other site 746361005721 epsilon subunit interface [polypeptide binding]; other site 746361005722 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 746361005723 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 746361005724 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 746361005725 beta subunit interaction interface [polypeptide binding]; other site 746361005726 Walker A motif; other site 746361005727 ATP binding site [chemical binding]; other site 746361005728 Walker B motif; other site 746361005729 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 746361005730 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 746361005731 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 746361005732 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 746361005733 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 746361005734 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 746361005735 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 746361005736 F0F1 ATP synthase subunit C; Provisional; Region: PRK13466 746361005737 Predicted esterase [General function prediction only]; Region: COG0627 746361005738 S-formylglutathione hydrolase; Region: PLN02442 746361005739 potential frameshift: common BLAST hit: gi|281492364|ref|YP_003354344.1| ComE operon protein 3, DNA internalization 746361005740 potential frameshift: common BLAST hit: gi|281492364|ref|YP_003354344.1| ComE operon protein 3, DNA internalization 746361005741 SLBB domain; Region: SLBB; pfam10531 746361005742 comEA protein; Region: comE; TIGR01259 746361005743 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 746361005744 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 746361005745 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 746361005746 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 746361005747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361005748 Walker A/P-loop; other site 746361005749 ATP binding site [chemical binding]; other site 746361005750 Q-loop/lid; other site 746361005751 ABC transporter signature motif; other site 746361005752 Walker B; other site 746361005753 D-loop; other site 746361005754 H-loop/switch region; other site 746361005755 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 746361005756 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 746361005757 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746361005758 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 746361005759 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 746361005760 transmembrane helices; other site 746361005761 Putative transcription activator [Transcription]; Region: TenA; COG0819 746361005762 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 746361005763 CHY zinc finger; Region: zf-CHY; pfam05495 746361005764 Biotin operon repressor [Transcription]; Region: BirA; COG1654 746361005765 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 746361005766 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 746361005767 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 746361005768 BioY family; Region: BioY; pfam02632 746361005769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746361005770 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 746361005771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746361005772 acyl-activating enzyme (AAE) consensus motif; other site 746361005773 AMP binding site [chemical binding]; other site 746361005774 active site 746361005775 CoA binding site [chemical binding]; other site 746361005776 Transposase; Region: HTH_Tnp_1; pfam01527 746361005777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 746361005779 Integrase core domain; Region: rve; pfam00665 746361005780 Integrase core domain; Region: rve_3; pfam13683 746361005781 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 746361005782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 746361005783 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 746361005784 FeS assembly protein SufB; Region: sufB; TIGR01980 746361005785 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 746361005786 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 746361005787 trimerization site [polypeptide binding]; other site 746361005788 active site 746361005789 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 746361005790 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 746361005791 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 746361005792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746361005793 catalytic residue [active] 746361005794 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 746361005795 FeS assembly protein SufD; Region: sufD; TIGR01981 746361005796 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 746361005797 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 746361005798 Walker A/P-loop; other site 746361005799 ATP binding site [chemical binding]; other site 746361005800 Q-loop/lid; other site 746361005801 ABC transporter signature motif; other site 746361005802 Walker B; other site 746361005803 D-loop; other site 746361005804 H-loop/switch region; other site 746361005805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005806 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361005807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361005808 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361005809 HTH-like domain; Region: HTH_21; pfam13276 746361005810 Integrase core domain; Region: rve; pfam00665 746361005811 Integrase core domain; Region: rve_2; pfam13333 746361005812 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 746361005813 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 746361005814 Mg++ binding site [ion binding]; other site 746361005815 putative catalytic motif [active] 746361005816 substrate binding site [chemical binding]; other site 746361005817 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 746361005818 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 746361005819 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 746361005820 Walker A/P-loop; other site 746361005821 ATP binding site [chemical binding]; other site 746361005822 Q-loop/lid; other site 746361005823 ABC transporter signature motif; other site 746361005824 Walker B; other site 746361005825 D-loop; other site 746361005826 H-loop/switch region; other site 746361005827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 746361005828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005829 dimer interface [polypeptide binding]; other site 746361005830 conserved gate region; other site 746361005831 putative PBP binding loops; other site 746361005832 ABC-ATPase subunit interface; other site 746361005833 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 746361005834 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 746361005835 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 746361005836 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 746361005837 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 746361005838 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 746361005839 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 746361005840 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 746361005841 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 746361005842 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 746361005843 G-loop; other site 746361005844 DNA binding site [nucleotide binding] 746361005845 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 746361005846 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 746361005847 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 746361005848 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 746361005849 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 746361005850 RPB1 interaction site [polypeptide binding]; other site 746361005851 RPB10 interaction site [polypeptide binding]; other site 746361005852 RPB11 interaction site [polypeptide binding]; other site 746361005853 RPB3 interaction site [polypeptide binding]; other site 746361005854 RPB12 interaction site [polypeptide binding]; other site 746361005855 CodY GAF-like domain; Region: CodY; pfam06018 746361005856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361005857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361005858 non-specific DNA binding site [nucleotide binding]; other site 746361005859 salt bridge; other site 746361005860 sequence-specific DNA binding site [nucleotide binding]; other site 746361005861 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 746361005862 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 746361005863 active site 746361005864 Zn binding site [ion binding]; other site 746361005865 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 746361005866 active site 746361005867 DNA binding site [nucleotide binding] 746361005868 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 746361005869 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 746361005870 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 746361005871 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746361005872 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361005873 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746361005874 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 746361005875 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 746361005876 NAD binding site [chemical binding]; other site 746361005877 substrate binding site [chemical binding]; other site 746361005878 catalytic Zn binding site [ion binding]; other site 746361005879 tetramer interface [polypeptide binding]; other site 746361005880 structural Zn binding site [ion binding]; other site 746361005881 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 746361005882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361005883 ATP binding site [chemical binding]; other site 746361005884 putative Mg++ binding site [ion binding]; other site 746361005885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361005886 nucleotide binding region [chemical binding]; other site 746361005887 ATP-binding site [chemical binding]; other site 746361005888 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 746361005889 HRDC domain; Region: HRDC; pfam00570 746361005890 inner membrane transporter YjeM; Provisional; Region: PRK15238 746361005891 peptidase T; Region: peptidase-T; TIGR01882 746361005892 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 746361005893 metal binding site [ion binding]; metal-binding site 746361005894 dimer interface [polypeptide binding]; other site 746361005895 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 746361005896 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 746361005897 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 746361005898 DHH family; Region: DHH; pfam01368 746361005899 DHHA2 domain; Region: DHHA2; pfam02833 746361005900 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 746361005901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361005902 FeS/SAM binding site; other site 746361005903 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 746361005904 Domain of unknown function DUF21; Region: DUF21; pfam01595 746361005905 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 746361005906 Transporter associated domain; Region: CorC_HlyC; smart01091 746361005907 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 746361005908 Domain of unknown function DUF20; Region: UPF0118; pfam01594 746361005909 Transcriptional regulator; Region: Rrf2; pfam02082 746361005910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361005911 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746361005912 NAD(P) binding site [chemical binding]; other site 746361005913 active site 746361005914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361005915 Coenzyme A binding pocket [chemical binding]; other site 746361005916 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 746361005917 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 746361005918 putative uracil binding site [chemical binding]; other site 746361005919 putative active site [active] 746361005920 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 746361005921 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746361005922 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746361005923 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 746361005924 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 746361005925 GIY-YIG motif/motif A; other site 746361005926 putative active site [active] 746361005927 putative metal binding site [ion binding]; other site 746361005928 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 746361005929 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 746361005930 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746361005931 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 746361005932 Thiamine pyrophosphokinase; Region: TPK; cd07995 746361005933 active site 746361005934 dimerization interface [polypeptide binding]; other site 746361005935 thiamine binding site [chemical binding]; other site 746361005936 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 746361005937 putative metal binding site [ion binding]; other site 746361005938 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 746361005939 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 746361005940 putative dimer interface [polypeptide binding]; other site 746361005941 putative anticodon binding site; other site 746361005942 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 746361005943 homodimer interface [polypeptide binding]; other site 746361005944 motif 1; other site 746361005945 motif 2; other site 746361005946 active site 746361005947 motif 3; other site 746361005948 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 746361005949 GIY-YIG motif/motif A; other site 746361005950 active site 746361005951 catalytic site [active] 746361005952 metal binding site [ion binding]; metal-binding site 746361005953 aspartate aminotransferase; Provisional; Region: PRK05764 746361005954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361005955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361005956 homodimer interface [polypeptide binding]; other site 746361005957 catalytic residue [active] 746361005958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 746361005959 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 746361005960 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746361005961 active site 746361005962 catalytic site [active] 746361005963 substrate binding site [chemical binding]; other site 746361005964 DEAD/DEAH box helicase; Region: DEAD; pfam00270 746361005965 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 746361005966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361005967 Ligand Binding Site [chemical binding]; other site 746361005968 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 746361005969 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 746361005970 peptide binding site [polypeptide binding]; other site 746361005971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 746361005972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005973 dimer interface [polypeptide binding]; other site 746361005974 conserved gate region; other site 746361005975 putative PBP binding loops; other site 746361005976 ABC-ATPase subunit interface; other site 746361005977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 746361005978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746361005979 dimer interface [polypeptide binding]; other site 746361005980 conserved gate region; other site 746361005981 putative PBP binding loops; other site 746361005982 ABC-ATPase subunit interface; other site 746361005983 potential frameshift: common BLAST hit: gi|116512716|ref|YP_811623.1| ABC-type oligopeptide transport system, ATPase component 746361005984 potential frameshift: common BLAST hit: gi|116512717|ref|YP_811624.1| ABC-type dipeptide/oligopeptide/nickel transport system, ATPase 746361005985 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 746361005986 23S rRNA binding site [nucleotide binding]; other site 746361005987 L21 binding site [polypeptide binding]; other site 746361005988 L13 binding site [polypeptide binding]; other site 746361005989 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 746361005990 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 746361005991 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 746361005992 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 746361005993 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 746361005994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361005995 motif II; other site 746361005996 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 746361005997 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 746361005998 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 746361005999 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 746361006000 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 746361006001 active site 746361006002 metal binding site [ion binding]; metal-binding site 746361006003 dimerization interface [polypeptide binding]; other site 746361006004 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 746361006005 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 746361006006 active site 746361006007 HIGH motif; other site 746361006008 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 746361006009 KMSKS motif; other site 746361006010 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 746361006011 tRNA binding surface [nucleotide binding]; other site 746361006012 anticodon binding site; other site 746361006013 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 746361006014 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 746361006015 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 746361006016 trimer interface [polypeptide binding]; other site 746361006017 active site 746361006018 substrate binding site [chemical binding]; other site 746361006019 CoA binding site [chemical binding]; other site 746361006020 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 746361006021 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 746361006022 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 746361006023 RNase E interface [polypeptide binding]; other site 746361006024 trimer interface [polypeptide binding]; other site 746361006025 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 746361006026 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 746361006027 RNase E interface [polypeptide binding]; other site 746361006028 trimer interface [polypeptide binding]; other site 746361006029 active site 746361006030 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 746361006031 putative nucleic acid binding region [nucleotide binding]; other site 746361006032 G-X-X-G motif; other site 746361006033 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 746361006034 RNA binding site [nucleotide binding]; other site 746361006035 domain interface; other site 746361006036 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 746361006037 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 746361006038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361006039 active site 746361006040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361006041 Ligand Binding Site [chemical binding]; other site 746361006042 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 746361006043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746361006044 catalytic residue [active] 746361006045 Putative amino acid metabolism; Region: DUF1831; pfam08866 746361006046 elongation factor Tu; Reviewed; Region: PRK00049 746361006047 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 746361006048 G1 box; other site 746361006049 GEF interaction site [polypeptide binding]; other site 746361006050 GTP/Mg2+ binding site [chemical binding]; other site 746361006051 Switch I region; other site 746361006052 G2 box; other site 746361006053 G3 box; other site 746361006054 Switch II region; other site 746361006055 G4 box; other site 746361006056 G5 box; other site 746361006057 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 746361006058 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 746361006059 Antibiotic Binding Site [chemical binding]; other site 746361006060 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 746361006061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746361006062 active site 746361006063 HIGH motif; other site 746361006064 nucleotide binding site [chemical binding]; other site 746361006065 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 746361006066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 746361006067 active site 746361006068 KMSKS motif; other site 746361006069 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 746361006070 tRNA binding surface [nucleotide binding]; other site 746361006071 anticodon binding site; other site 746361006072 DivIVA protein; Region: DivIVA; pfam05103 746361006073 DivIVA domain; Region: DivI1A_domain; TIGR03544 746361006074 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 746361006075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361006076 RNA binding surface [nucleotide binding]; other site 746361006077 YGGT family; Region: YGGT; pfam02325 746361006078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 746361006079 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 746361006080 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746361006081 catalytic residue [active] 746361006082 cell division protein FtsZ; Validated; Region: PRK09330 746361006083 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 746361006084 nucleotide binding site [chemical binding]; other site 746361006085 SulA interaction site; other site 746361006086 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 746361006087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361006088 nucleotide binding site [chemical binding]; other site 746361006089 Cell division protein FtsA; Region: FtsA; pfam14450 746361006090 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 746361006091 EDD domain protein, DegV family; Region: DegV; TIGR00762 746361006092 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 746361006093 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 746361006094 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 746361006095 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746361006096 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 746361006097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746361006098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746361006099 active site 746361006100 catalytic tetrad [active] 746361006101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361006102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361006103 putative substrate translocation pore; other site 746361006104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361006105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361006106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361006107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 746361006108 dimerization interface [polypeptide binding]; other site 746361006109 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 746361006110 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361006111 DNA binding residues [nucleotide binding] 746361006112 putative dimer interface [polypeptide binding]; other site 746361006113 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 746361006114 trimer interface [polypeptide binding]; other site 746361006115 active site 746361006116 G bulge; other site 746361006117 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361006118 Zn2+ binding site [ion binding]; other site 746361006119 Mg2+ binding site [ion binding]; other site 746361006120 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 746361006121 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 746361006122 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 746361006123 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 746361006124 dimer interface [polypeptide binding]; other site 746361006125 ADP-ribose binding site [chemical binding]; other site 746361006126 active site 746361006127 nudix motif; other site 746361006128 metal binding site [ion binding]; metal-binding site 746361006129 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 746361006130 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 746361006131 Substrate binding site; other site 746361006132 Mg++ binding site; other site 746361006133 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 746361006134 active site 746361006135 substrate binding site [chemical binding]; other site 746361006136 CoA binding site [chemical binding]; other site 746361006137 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 746361006138 pyrroline-5-carboxylate reductase; Region: PLN02688 746361006139 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 746361006140 16S/18S rRNA binding site [nucleotide binding]; other site 746361006141 S13e-L30e interaction site [polypeptide binding]; other site 746361006142 25S rRNA binding site [nucleotide binding]; other site 746361006143 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 746361006144 Catalytic domain of Protein Kinases; Region: PKc; cd00180 746361006145 active site 746361006146 ATP binding site [chemical binding]; other site 746361006147 substrate binding site [chemical binding]; other site 746361006148 activation loop (A-loop); other site 746361006149 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 746361006150 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 746361006151 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 746361006152 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 746361006153 active site 746361006154 16S rRNA methyltransferase B; Provisional; Region: PRK14902 746361006155 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 746361006156 putative RNA binding site [nucleotide binding]; other site 746361006157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361006158 S-adenosylmethionine binding site [chemical binding]; other site 746361006159 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 746361006160 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 746361006161 active site 746361006162 phage holin, LL-H family; Region: holin_LLH; TIGR01673 746361006163 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 746361006164 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 746361006165 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cd07964 746361006166 trimer interface [polypeptide binding]; other site 746361006167 potential frameshift: common BLAST hit: gi|281491554|ref|YP_003353534.1| Phage protein, tail component 746361006168 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 746361006169 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 746361006170 N-acetyl-D-glucosamine binding site [chemical binding]; other site 746361006171 catalytic residue [active] 746361006172 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 746361006173 Phage major tail protein; Region: Phage_tail; pfam04630 746361006174 Protein of unknown function (DUF806); Region: DUF806; pfam05657 746361006175 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 746361006176 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 746361006177 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 746361006178 oligomerization interface [polypeptide binding]; other site 746361006179 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 746361006180 Phage capsid family; Region: Phage_capsid; pfam05065 746361006181 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 746361006182 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 746361006183 oligomer interface [polypeptide binding]; other site 746361006184 active site residues [active] 746361006185 Phage-related protein [Function unknown]; Region: COG4695 746361006186 Phage portal protein; Region: Phage_portal; pfam04860 746361006187 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 746361006188 Phage Terminase; Region: Terminase_1; pfam03354 746361006189 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361006190 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 746361006191 Phage terminase, small subunit; Region: Terminase_4; pfam05119 746361006192 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 746361006193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 746361006194 active site 746361006195 Protein of unknown function (DUF722); Region: DUF722; pfam05263 746361006196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361006197 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746361006198 Walker A motif; other site 746361006199 ATP binding site [chemical binding]; other site 746361006200 Walker B motif; other site 746361006201 arginine finger; other site 746361006202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 746361006203 Integrase core domain; Region: rve; pfam00665 746361006204 Prophage protein (DUF1660); Region: DUF1660; pfam07874 746361006205 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 746361006206 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 746361006207 trimer interface [polypeptide binding]; other site 746361006208 active site 746361006209 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 746361006210 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 746361006211 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 746361006212 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 746361006213 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 746361006214 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 746361006215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 746361006216 dimer interface [polypeptide binding]; other site 746361006217 ssDNA binding site [nucleotide binding]; other site 746361006218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361006219 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 746361006220 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 746361006221 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 746361006222 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 746361006223 Prophage antirepressor [Transcription]; Region: COG3617 746361006224 BRO family, N-terminal domain; Region: Bro-N; smart01040 746361006225 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 746361006226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361006227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361006228 non-specific DNA binding site [nucleotide binding]; other site 746361006229 salt bridge; other site 746361006230 sequence-specific DNA binding site [nucleotide binding]; other site 746361006231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361006232 non-specific DNA binding site [nucleotide binding]; other site 746361006233 salt bridge; other site 746361006234 sequence-specific DNA binding site [nucleotide binding]; other site 746361006235 Domain of unknown function (DUF955); Region: DUF955; cl01076 746361006236 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 746361006237 Int/Topo IB signature motif; other site 746361006238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 746361006239 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 746361006240 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 746361006241 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 746361006242 putative active site [active] 746361006243 substrate binding site [chemical binding]; other site 746361006244 putative cosubstrate binding site; other site 746361006245 catalytic site [active] 746361006246 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 746361006247 substrate binding site [chemical binding]; other site 746361006248 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 746361006249 dimer interface [polypeptide binding]; other site 746361006250 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 746361006251 nudix motif; other site 746361006252 SnoaL-like domain; Region: SnoaL_2; pfam12680 746361006253 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 746361006254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361006255 ATP binding site [chemical binding]; other site 746361006256 putative Mg++ binding site [ion binding]; other site 746361006257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361006258 nucleotide binding region [chemical binding]; other site 746361006259 ATP-binding site [chemical binding]; other site 746361006260 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 746361006261 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 746361006262 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 746361006263 catalytic site [active] 746361006264 G-X2-G-X-G-K; other site 746361006265 phosphodiesterase; Provisional; Region: PRK12704 746361006266 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 746361006267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361006268 Zn2+ binding site [ion binding]; other site 746361006269 Mg2+ binding site [ion binding]; other site 746361006270 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 746361006271 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 746361006272 active site 746361006273 trimer interface [polypeptide binding]; other site 746361006274 allosteric site; other site 746361006275 active site lid [active] 746361006276 S-adenosylmethionine synthetase; Validated; Region: PRK05250 746361006277 S-adenosylmethionine synthetase; Validated; Region: PRK05250 746361006278 S-adenosylmethionine synthetase; Validated; Region: PRK05250 746361006279 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 746361006280 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 746361006281 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 746361006282 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 746361006283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361006284 S-adenosylmethionine binding site [chemical binding]; other site 746361006285 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 746361006286 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 746361006287 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 746361006288 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 746361006289 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 746361006290 Uncharacterized conserved protein [Function unknown]; Region: COG3595 746361006291 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 746361006292 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 746361006293 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 746361006294 CHAP domain; Region: CHAP; pfam05257 746361006295 potential frameshift: common BLAST hit: gi|125625249|ref|YP_001033732.1| transposase for insertion sequence element IS905N 746361006296 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 746361006297 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 746361006298 intersubunit interface [polypeptide binding]; other site 746361006299 active site 746361006300 zinc binding site [ion binding]; other site 746361006301 Na+ binding site [ion binding]; other site 746361006302 potential protein location (hypothetical protein LLNZ_11190 [Lactococcus lactis subsp. cremoris NZ9000]) that overlaps RNA (5S ribosomal RNA) 746361006303 Predicted membrane protein [Function unknown]; Region: COG2860 746361006304 UPF0126 domain; Region: UPF0126; pfam03458 746361006305 UPF0126 domain; Region: UPF0126; pfam03458 746361006306 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 746361006307 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 746361006308 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 746361006309 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 746361006310 active site 746361006311 dimer interface [polypeptide binding]; other site 746361006312 motif 1; other site 746361006313 motif 2; other site 746361006314 motif 3; other site 746361006315 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 746361006316 anticodon binding site; other site 746361006317 ATP cone domain; Region: ATP-cone; pfam03477 746361006318 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 746361006319 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 746361006320 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 746361006321 dimer interface [polypeptide binding]; other site 746361006322 FMN binding site [chemical binding]; other site 746361006323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361006324 Transposase; Region: HTH_Tnp_1; pfam01527 746361006325 putative transposase OrfB; Reviewed; Region: PHA02517 746361006326 HTH-like domain; Region: HTH_21; pfam13276 746361006327 Integrase core domain; Region: rve; pfam00665 746361006328 Integrase core domain; Region: rve_3; pfam13683 746361006329 HTH-like domain; Region: HTH_21; pfam13276 746361006330 Integrase core domain; Region: rve; pfam00665 746361006331 Integrase core domain; Region: rve_2; pfam13333 746361006332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361006333 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361006334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 746361006335 Helix-turn-helix domain; Region: HTH_28; pfam13518 746361006336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361006337 active site 746361006338 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 746361006339 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 746361006340 potential frameshift: common BLAST hit: gi|116512853|ref|YP_811760.1| bifunctional beta-cystathionase/maltose regulon repressor 746361006341 cystathionine gamma-synthase; Reviewed; Region: PRK07269 746361006342 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746361006343 homodimer interface [polypeptide binding]; other site 746361006344 substrate-cofactor binding pocket; other site 746361006345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361006346 catalytic residue [active] 746361006347 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 746361006348 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 746361006349 proposed active site lysine [active] 746361006350 conserved cys residue [active] 746361006351 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 746361006352 nudix motif; other site 746361006353 Predicted permeases [General function prediction only]; Region: COG0679 746361006354 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 746361006355 active site 746361006356 catalytic residues [active] 746361006357 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 746361006358 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 746361006359 generic binding surface II; other site 746361006360 generic binding surface I; other site 746361006361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746361006362 Zn2+ binding site [ion binding]; other site 746361006363 Mg2+ binding site [ion binding]; other site 746361006364 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 746361006365 RmuC family; Region: RmuC; pfam02646 746361006366 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 746361006367 active site 746361006368 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 746361006369 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 746361006370 substrate binding site [chemical binding]; other site 746361006371 hexamer interface [polypeptide binding]; other site 746361006372 metal binding site [ion binding]; metal-binding site 746361006373 GTPase RsgA; Reviewed; Region: PRK00098 746361006374 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 746361006375 RNA binding site [nucleotide binding]; other site 746361006376 homodimer interface [polypeptide binding]; other site 746361006377 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 746361006378 GTPase/Zn-binding domain interface [polypeptide binding]; other site 746361006379 GTP/Mg2+ binding site [chemical binding]; other site 746361006380 G4 box; other site 746361006381 G1 box; other site 746361006382 Switch I region; other site 746361006383 G2 box; other site 746361006384 G3 box; other site 746361006385 Switch II region; other site 746361006386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 746361006387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 746361006388 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 746361006389 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 746361006390 putative tRNA-binding site [nucleotide binding]; other site 746361006391 B3/4 domain; Region: B3_4; pfam03483 746361006392 tRNA synthetase B5 domain; Region: B5; smart00874 746361006393 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 746361006394 dimer interface [polypeptide binding]; other site 746361006395 motif 1; other site 746361006396 motif 3; other site 746361006397 motif 2; other site 746361006398 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 746361006399 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 746361006400 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 746361006401 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 746361006402 dimer interface [polypeptide binding]; other site 746361006403 motif 1; other site 746361006404 active site 746361006405 motif 2; other site 746361006406 motif 3; other site 746361006407 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 746361006408 Predicted transcriptional regulators [Transcription]; Region: COG1695 746361006409 Transcriptional regulator PadR-like family; Region: PadR; cl17335 746361006410 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 746361006411 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 746361006412 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 746361006413 putative active site [active] 746361006414 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 746361006415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 746361006416 Interdomain contacts; other site 746361006417 Cytokine receptor motif; other site 746361006418 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 746361006419 aromatic chitin/cellulose binding site residues [chemical binding]; other site 746361006420 Chitin binding domain; Region: Chitin_bind_3; pfam03067 746361006421 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 746361006422 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 746361006423 GDP-binding site [chemical binding]; other site 746361006424 ACT binding site; other site 746361006425 IMP binding site; other site 746361006426 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 746361006427 Cadmium resistance transporter; Region: Cad; pfam03596 746361006428 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 746361006429 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 746361006430 dimerization interface [polypeptide binding]; other site 746361006431 domain crossover interface; other site 746361006432 redox-dependent activation switch; other site 746361006433 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 746361006434 RibD C-terminal domain; Region: RibD_C; cl17279 746361006435 Protein of unknown function (DUF805); Region: DUF805; pfam05656 746361006436 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 746361006437 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 746361006438 FMN binding site [chemical binding]; other site 746361006439 active site 746361006440 catalytic residues [active] 746361006441 substrate binding site [chemical binding]; other site 746361006442 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746361006443 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006444 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006445 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 746361006446 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746361006447 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006448 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006449 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 746361006450 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746361006451 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006452 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746361006453 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 746361006454 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 746361006455 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 746361006456 dimer interface [polypeptide binding]; other site 746361006457 anticodon binding site; other site 746361006458 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 746361006459 homodimer interface [polypeptide binding]; other site 746361006460 motif 1; other site 746361006461 active site 746361006462 motif 2; other site 746361006463 GAD domain; Region: GAD; pfam02938 746361006464 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 746361006465 active site 746361006466 motif 3; other site 746361006467 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 746361006468 nucleotide binding site/active site [active] 746361006469 HIT family signature motif; other site 746361006470 catalytic residue [active] 746361006471 histidyl-tRNA synthetase; Region: hisS; TIGR00442 746361006472 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 746361006473 dimer interface [polypeptide binding]; other site 746361006474 motif 1; other site 746361006475 active site 746361006476 motif 2; other site 746361006477 motif 3; other site 746361006478 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 746361006479 anticodon binding site; other site 746361006480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361006481 non-specific DNA binding site [nucleotide binding]; other site 746361006482 salt bridge; other site 746361006483 sequence-specific DNA binding site [nucleotide binding]; other site 746361006484 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361006485 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 746361006486 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 746361006487 Helix-turn-helix domain; Region: HTH_25; pfam13413 746361006488 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746361006489 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 746361006490 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746361006491 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746361006492 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746361006493 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 746361006494 recF protein; Region: recf; TIGR00611 746361006495 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 746361006496 Walker A/P-loop; other site 746361006497 ATP binding site [chemical binding]; other site 746361006498 Q-loop/lid; other site 746361006499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746361006500 ABC transporter signature motif; other site 746361006501 Walker B; other site 746361006502 D-loop; other site 746361006503 H-loop/switch region; other site 746361006504 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 746361006505 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 746361006506 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 746361006507 DNA binding residues [nucleotide binding] 746361006508 putative dimer interface [polypeptide binding]; other site 746361006509 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 746361006510 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 746361006511 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 746361006512 NAD binding site [chemical binding]; other site 746361006513 homodimer interface [polypeptide binding]; other site 746361006514 active site 746361006515 substrate binding site [chemical binding]; other site 746361006516 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 746361006517 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 746361006518 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 746361006519 galactokinase; Provisional; Region: PRK05322 746361006520 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 746361006521 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 746361006522 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 746361006523 active site 746361006524 catalytic residues [active] 746361006525 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 746361006526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361006527 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361006528 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361006529 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361006530 putative active site [active] 746361006531 potential frameshift: common BLAST hit: gi|116512910|ref|YP_811817.1| aryl-alcohol dehydrogenase family oxidoreductase 746361006532 potential frameshift: common BLAST hit: gi|116512910|ref|YP_811817.1| aryl-alcohol dehydrogenase family oxidoreductase 746361006533 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 746361006534 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 746361006535 active site 746361006536 (T/H)XGH motif; other site 746361006537 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 746361006538 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 746361006539 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 746361006540 NAD binding site [chemical binding]; other site 746361006541 ligand binding site [chemical binding]; other site 746361006542 catalytic site [active] 746361006543 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 746361006544 Peptidase family U32; Region: Peptidase_U32; pfam01136 746361006545 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 746361006546 Peptidase family U32; Region: Peptidase_U32; pfam01136 746361006547 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 746361006548 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 746361006549 Methyltransferase domain; Region: Methyltransf_11; pfam08241 746361006550 AAA domain; Region: AAA_23; pfam13476 746361006551 AAA domain; Region: AAA_21; pfam13304 746361006552 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 746361006553 Phage associated DNA primase [General function prediction only]; Region: COG3378 746361006554 D5 N terminal like; Region: D5_N; smart00885 746361006555 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 746361006556 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 746361006557 polymerase nucleotide-binding site; other site 746361006558 DNA-binding residues [nucleotide binding]; DNA binding site 746361006559 nucleotide binding site [chemical binding]; other site 746361006560 primase nucleotide-binding site [nucleotide binding]; other site 746361006561 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 746361006562 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 746361006563 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 746361006564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361006565 sequence-specific DNA binding site [nucleotide binding]; other site 746361006566 salt bridge; other site 746361006567 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746361006568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361006569 non-specific DNA binding site [nucleotide binding]; other site 746361006570 salt bridge; other site 746361006571 sequence-specific DNA binding site [nucleotide binding]; other site 746361006572 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 746361006573 Uncharacterized conserved protein [Function unknown]; Region: COG4127 746361006574 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 746361006575 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 746361006576 Int/Topo IB signature motif; other site 746361006577 CutC family; Region: CutC; pfam03932 746361006578 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 746361006579 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 746361006580 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746361006581 Walker A/P-loop; other site 746361006582 ATP binding site [chemical binding]; other site 746361006583 Q-loop/lid; other site 746361006584 ABC transporter signature motif; other site 746361006585 Walker B; other site 746361006586 D-loop; other site 746361006587 H-loop/switch region; other site 746361006588 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 746361006589 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 746361006590 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 746361006591 putative active site [active] 746361006592 catalytic site [active] 746361006593 putative metal binding site [ion binding]; other site 746361006594 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 746361006595 HIT family signature motif; other site 746361006596 catalytic residue [active] 746361006597 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 746361006598 mRNA/rRNA interface [nucleotide binding]; other site 746361006599 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 746361006600 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 746361006601 23S rRNA interface [nucleotide binding]; other site 746361006602 L7/L12 interface [polypeptide binding]; other site 746361006603 putative thiostrepton binding site; other site 746361006604 L25 interface [polypeptide binding]; other site 746361006605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 746361006606 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746361006607 Walker A/P-loop; other site 746361006608 ATP binding site [chemical binding]; other site 746361006609 Q-loop/lid; other site 746361006610 ABC transporter signature motif; other site 746361006611 Walker B; other site 746361006612 D-loop; other site 746361006613 H-loop/switch region; other site 746361006614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 746361006615 methionine sulfoxide reductase A; Provisional; Region: PRK14054 746361006616 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 746361006617 S1 domain; Region: S1_2; pfam13509 746361006618 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746361006619 RNA binding site [nucleotide binding]; other site 746361006620 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 746361006621 RNA binding site [nucleotide binding]; other site 746361006622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746361006623 Coenzyme A binding pocket [chemical binding]; other site 746361006624 ribosome recycling factor; Reviewed; Region: frr; PRK00083 746361006625 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 746361006626 hinge region; other site 746361006627 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 746361006628 putative nucleotide binding site [chemical binding]; other site 746361006629 uridine monophosphate binding site [chemical binding]; other site 746361006630 homohexameric interface [polypeptide binding]; other site 746361006631 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 746361006632 propionate/acetate kinase; Provisional; Region: PRK12379 746361006633 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 746361006634 propionate/acetate kinase; Provisional; Region: PRK12379 746361006635 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 746361006636 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746361006637 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 746361006638 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 746361006639 G1 box; other site 746361006640 putative GEF interaction site [polypeptide binding]; other site 746361006641 GTP/Mg2+ binding site [chemical binding]; other site 746361006642 Switch I region; other site 746361006643 G2 box; other site 746361006644 G3 box; other site 746361006645 Switch II region; other site 746361006646 G4 box; other site 746361006647 G5 box; other site 746361006648 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 746361006649 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 746361006650 LytTr DNA-binding domain; Region: LytTR; cl04498 746361006651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 746361006652 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 746361006653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361006654 nucleotide binding site [chemical binding]; other site 746361006655 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746361006656 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 746361006657 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 746361006658 dimerization interface [polypeptide binding]; other site 746361006659 DPS ferroxidase diiron center [ion binding]; other site 746361006660 ion pore; other site 746361006661 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 746361006662 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 746361006663 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 746361006664 active site 746361006665 DNA polymerase IV; Validated; Region: PRK02406 746361006666 DNA binding site [nucleotide binding] 746361006667 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 746361006668 putative deacylase active site [active] 746361006669 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 746361006670 transaminase; Validated; Region: PRK07324 746361006671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746361006672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361006673 homodimer interface [polypeptide binding]; other site 746361006674 catalytic residue [active] 746361006675 carbamate kinase; Reviewed; Region: PRK12686 746361006676 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 746361006677 putative substrate binding site [chemical binding]; other site 746361006678 nucleotide binding site [chemical binding]; other site 746361006679 nucleotide binding site [chemical binding]; other site 746361006680 homodimer interface [polypeptide binding]; other site 746361006681 carbamate kinase; Reviewed; Region: PRK12686 746361006682 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 746361006683 putative substrate binding site [chemical binding]; other site 746361006684 nucleotide binding site [chemical binding]; other site 746361006685 nucleotide binding site [chemical binding]; other site 746361006686 homodimer interface [polypeptide binding]; other site 746361006687 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 746361006688 ornithine carbamoyltransferase; Validated; Region: PRK02102 746361006689 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 746361006690 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 746361006691 arginine deiminase; Provisional; Region: PRK01388 746361006692 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 746361006693 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 746361006694 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 746361006695 active site 746361006696 HIGH motif; other site 746361006697 KMSK motif region; other site 746361006698 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 746361006699 tRNA binding surface [nucleotide binding]; other site 746361006700 anticodon binding site; other site 746361006701 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 746361006702 arginine repressor; Region: argR_whole; TIGR01529 746361006703 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 746361006704 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 746361006705 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746361006706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746361006707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746361006708 SWIM zinc finger; Region: SWIM; pfam04434 746361006709 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 746361006710 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 746361006711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361006712 ATP binding site [chemical binding]; other site 746361006713 putative Mg++ binding site [ion binding]; other site 746361006714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361006715 nucleotide binding region [chemical binding]; other site 746361006716 ATP-binding site [chemical binding]; other site 746361006717 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 746361006718 metal ion-dependent adhesion site (MIDAS); other site 746361006719 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 746361006720 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 746361006721 PYR/PP interface [polypeptide binding]; other site 746361006722 dimer interface [polypeptide binding]; other site 746361006723 tetramer interface [polypeptide binding]; other site 746361006724 TPP binding site [chemical binding]; other site 746361006725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 746361006726 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 746361006727 TPP-binding site [chemical binding]; other site 746361006728 Beta-lactamase; Region: Beta-lactamase; pfam00144 746361006729 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746361006730 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 746361006731 Domain of unknown function (DU1801); Region: DUF1801; cl17490 746361006732 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 746361006733 CAAX protease self-immunity; Region: Abi; pfam02517 746361006734 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 746361006735 amphipathic channel; other site 746361006736 Asn-Pro-Ala signature motifs; other site 746361006737 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 746361006738 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 746361006739 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 746361006740 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 746361006741 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 746361006742 catalytic triad [active] 746361006743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 746361006744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746361006745 substrate binding pocket [chemical binding]; other site 746361006746 membrane-bound complex binding site; other site 746361006747 hinge residues; other site 746361006748 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 746361006749 TrkA-N domain; Region: TrkA_N; pfam02254 746361006750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746361006751 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746361006752 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 746361006753 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 746361006754 active site 746361006755 HIGH motif; other site 746361006756 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 746361006757 active site 746361006758 KMSKS motif; other site 746361006759 potential frameshift: common BLAST hit: gi|116513003|ref|YP_811910.1| amidase 746361006760 Isochorismatase family; Region: Isochorismatase; pfam00857 746361006761 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 746361006762 catalytic triad [active] 746361006763 conserved cis-peptide bond; other site 746361006764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746361006765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746361006766 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 746361006767 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 746361006768 active site 746361006769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 746361006770 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 746361006771 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 746361006772 Predicted transcriptional regulators [Transcription]; Region: COG1695 746361006773 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 746361006774 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 746361006775 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 746361006776 putative active site [active] 746361006777 Predicted membrane protein [Function unknown]; Region: COG3619 746361006778 DNA repair protein RadA; Provisional; Region: PRK11823 746361006779 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 746361006780 Walker A motif/ATP binding site; other site 746361006781 ATP binding site [chemical binding]; other site 746361006782 Walker B motif; other site 746361006783 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 746361006784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361006785 active site 746361006786 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 746361006787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361006788 active site 746361006789 motif I; other site 746361006790 motif II; other site 746361006791 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361006792 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 746361006793 dimer interface [polypeptide binding]; other site 746361006794 active site 746361006795 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 746361006796 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 746361006797 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 746361006798 GDP-Fucose binding site [chemical binding]; other site 746361006799 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746361006800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361006801 active site 746361006802 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746361006803 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746361006804 active site 746361006805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746361006806 FemAB family; Region: FemAB; pfam02388 746361006807 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 746361006808 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 746361006809 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 746361006810 alphaNTD homodimer interface [polypeptide binding]; other site 746361006811 alphaNTD - beta interaction site [polypeptide binding]; other site 746361006812 alphaNTD - beta' interaction site [polypeptide binding]; other site 746361006813 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 746361006814 30S ribosomal protein S11; Validated; Region: PRK05309 746361006815 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 746361006816 30S ribosomal protein S13; Region: bact_S13; TIGR03631 746361006817 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 746361006818 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 746361006819 rRNA binding site [nucleotide binding]; other site 746361006820 predicted 30S ribosome binding site; other site 746361006821 adenylate kinase; Reviewed; Region: adk; PRK00279 746361006822 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 746361006823 AMP-binding site [chemical binding]; other site 746361006824 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 746361006825 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 746361006826 SecY translocase; Region: SecY; pfam00344 746361006827 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 746361006828 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 746361006829 23S rRNA binding site [nucleotide binding]; other site 746361006830 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 746361006831 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 746361006832 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 746361006833 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 746361006834 5S rRNA interface [nucleotide binding]; other site 746361006835 L27 interface [polypeptide binding]; other site 746361006836 23S rRNA interface [nucleotide binding]; other site 746361006837 L5 interface [polypeptide binding]; other site 746361006838 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 746361006839 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 746361006840 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 746361006841 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 746361006842 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 746361006843 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 746361006844 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 746361006845 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 746361006846 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 746361006847 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 746361006848 RNA binding site [nucleotide binding]; other site 746361006849 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 746361006850 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 746361006851 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 746361006852 23S rRNA interface [nucleotide binding]; other site 746361006853 putative translocon interaction site; other site 746361006854 signal recognition particle (SRP54) interaction site; other site 746361006855 L23 interface [polypeptide binding]; other site 746361006856 trigger factor interaction site; other site 746361006857 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 746361006858 23S rRNA interface [nucleotide binding]; other site 746361006859 5S rRNA interface [nucleotide binding]; other site 746361006860 putative antibiotic binding site [chemical binding]; other site 746361006861 L25 interface [polypeptide binding]; other site 746361006862 L27 interface [polypeptide binding]; other site 746361006863 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 746361006864 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 746361006865 G-X-X-G motif; other site 746361006866 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 746361006867 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 746361006868 putative translocon binding site; other site 746361006869 protein-rRNA interface [nucleotide binding]; other site 746361006870 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 746361006871 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 746361006872 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 746361006873 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 746361006874 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 746361006875 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 746361006876 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 746361006877 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 746361006878 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 746361006879 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 746361006880 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 746361006881 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 746361006882 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 746361006883 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 746361006884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746361006885 catalytic residue [active] 746361006886 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 746361006887 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 746361006888 putative homodimer interface [polypeptide binding]; other site 746361006889 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 746361006890 heterodimer interface [polypeptide binding]; other site 746361006891 homodimer interface [polypeptide binding]; other site 746361006892 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 746361006893 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 746361006894 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 746361006895 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 746361006896 catalytic triad [active] 746361006897 catalytic triad [active] 746361006898 oxyanion hole [active] 746361006899 Transglycosylase; Region: Transgly; pfam00912 746361006900 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 746361006901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 746361006902 Predicted membrane protein [Function unknown]; Region: COG2323 746361006903 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 746361006904 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 746361006905 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746361006906 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746361006907 active site 746361006908 potential frameshift: common BLAST hit: gi|116513067|ref|YP_811974.1| transposase 746361006909 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 746361006910 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746361006911 ABC-ATPase subunit interface; other site 746361006912 dimer interface [polypeptide binding]; other site 746361006913 putative PBP binding regions; other site 746361006914 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 746361006915 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 746361006916 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 746361006917 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 746361006918 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 746361006919 metal binding site [ion binding]; metal-binding site 746361006920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746361006921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361006922 putative DNA binding site [nucleotide binding]; other site 746361006923 putative Zn2+ binding site [ion binding]; other site 746361006924 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 746361006925 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 746361006926 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 746361006927 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 746361006928 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 746361006929 Type II/IV secretion system protein; Region: T2SE; pfam00437 746361006930 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 746361006931 Walker A motif; other site 746361006932 ATP binding site [chemical binding]; other site 746361006933 Walker B motif; other site 746361006934 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 746361006935 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 746361006936 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 746361006937 generic binding surface II; other site 746361006938 generic binding surface I; other site 746361006939 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 746361006940 generic binding surface II; other site 746361006941 generic binding surface I; other site 746361006942 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 746361006943 active site 746361006944 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746361006945 active site 746361006946 catalytic site [active] 746361006947 substrate binding site [chemical binding]; other site 746361006948 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 746361006949 potential frameshift: common BLAST hit: gi|116513080|ref|YP_811987.1| NAD(FAD)-dependent dehydrogenase 746361006950 prolyl-tRNA synthetase; Provisional; Region: PRK09194 746361006951 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 746361006952 dimer interface [polypeptide binding]; other site 746361006953 motif 1; other site 746361006954 active site 746361006955 motif 2; other site 746361006956 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 746361006957 putative deacylase active site [active] 746361006958 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 746361006959 active site 746361006960 motif 3; other site 746361006961 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 746361006962 anticodon binding site; other site 746361006963 RIP metalloprotease RseP; Region: TIGR00054 746361006964 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 746361006965 active site 746361006966 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 746361006967 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 746361006968 protein binding site [polypeptide binding]; other site 746361006969 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 746361006970 putative substrate binding region [chemical binding]; other site 746361006971 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 746361006972 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 746361006973 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 746361006974 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 746361006975 catalytic residue [active] 746361006976 putative FPP diphosphate binding site; other site 746361006977 putative FPP binding hydrophobic cleft; other site 746361006978 dimer interface [polypeptide binding]; other site 746361006979 putative IPP diphosphate binding site; other site 746361006980 Preprotein translocase subunit; Region: YajC; cl00806 746361006981 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 746361006982 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 746361006983 active site 746361006984 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 746361006985 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 746361006986 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 746361006987 protein binding site [polypeptide binding]; other site 746361006988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746361006989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746361006990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746361006991 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 746361006992 putative ADP-binding pocket [chemical binding]; other site 746361006993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 746361006994 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 746361006995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361006996 S-adenosylmethionine binding site [chemical binding]; other site 746361006997 DNA polymerase I; Provisional; Region: PRK05755 746361006998 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 746361006999 active site 746361007000 metal binding site 1 [ion binding]; metal-binding site 746361007001 putative 5' ssDNA interaction site; other site 746361007002 metal binding site 3; metal-binding site 746361007003 metal binding site 2 [ion binding]; metal-binding site 746361007004 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 746361007005 putative DNA binding site [nucleotide binding]; other site 746361007006 putative metal binding site [ion binding]; other site 746361007007 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 746361007008 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 746361007009 active site 746361007010 DNA binding site [nucleotide binding] 746361007011 catalytic site [active] 746361007012 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 746361007013 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 746361007014 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746361007015 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 746361007016 elongation factor Ts; Provisional; Region: tsf; PRK09377 746361007017 UBA/TS-N domain; Region: UBA; pfam00627 746361007018 Elongation factor TS; Region: EF_TS; pfam00889 746361007019 Elongation factor TS; Region: EF_TS; pfam00889 746361007020 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 746361007021 rRNA interaction site [nucleotide binding]; other site 746361007022 S8 interaction site; other site 746361007023 putative laminin-1 binding site; other site 746361007024 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 746361007025 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 746361007026 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 746361007027 putative catalytic cysteine [active] 746361007028 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 746361007029 putative active site [active] 746361007030 metal binding site [ion binding]; metal-binding site 746361007031 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 746361007032 dimer interface [polypeptide binding]; other site 746361007033 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 746361007034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361007035 FeS/SAM binding site; other site 746361007036 potential frameshift: common BLAST hit: gi|281492813|ref|YP_003354793.1| Fe-S oxidoreductase, radical SAM superfamily/transporter, MF 746361007037 Helix-turn-helix domain; Region: HTH_19; pfam12844 746361007038 non-specific DNA binding site [nucleotide binding]; other site 746361007039 salt bridge; other site 746361007040 sequence-specific DNA binding site [nucleotide binding]; other site 746361007041 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 746361007042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361007043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361007044 putative substrate translocation pore; other site 746361007045 KxxxW cyclic peptide radical SAM maturase; Region: rSAM_pep_cyc; TIGR04080 746361007046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746361007047 FeS/SAM binding site; other site 746361007048 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 746361007049 KxxxW-cyclized secreted peptide; Region: phero_cyc_pep; TIGR04079 746361007050 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 746361007051 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 746361007052 protein binding site [polypeptide binding]; other site 746361007053 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 746361007054 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 746361007055 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 746361007056 active site 746361007057 (T/H)XGH motif; other site 746361007058 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 746361007059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361007060 S-adenosylmethionine binding site [chemical binding]; other site 746361007061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361007062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361007063 putative substrate translocation pore; other site 746361007064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361007065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361007066 putative substrate translocation pore; other site 746361007067 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 746361007068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746361007069 DNA binding residues [nucleotide binding] 746361007070 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 746361007071 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 746361007072 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 746361007073 active site 746361007074 dimer interface [polypeptide binding]; other site 746361007075 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 746361007076 dimer interface [polypeptide binding]; other site 746361007077 active site 746361007078 Flagellin N-methylase; Region: FliB; pfam03692 746361007079 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 746361007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361007081 NAD(P) binding site [chemical binding]; other site 746361007082 active site 746361007083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361007084 non-specific DNA binding site [nucleotide binding]; other site 746361007085 salt bridge; other site 746361007086 sequence-specific DNA binding site [nucleotide binding]; other site 746361007087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361007088 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 746361007089 NAD(P) binding site [chemical binding]; other site 746361007090 active site 746361007091 Predicted transcriptional regulators [Transcription]; Region: COG1733 746361007092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746361007093 putative DNA binding site [nucleotide binding]; other site 746361007094 dimerization interface [polypeptide binding]; other site 746361007095 putative Zn2+ binding site [ion binding]; other site 746361007096 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 746361007097 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746361007098 active site 746361007099 HIGH motif; other site 746361007100 nucleotide binding site [chemical binding]; other site 746361007101 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 746361007102 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 746361007103 active site 746361007104 KMSKS motif; other site 746361007105 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 746361007106 tRNA binding surface [nucleotide binding]; other site 746361007107 anticodon binding site; other site 746361007108 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 746361007109 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 746361007110 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 746361007111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 746361007112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 746361007113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746361007114 Coenzyme A binding pocket [chemical binding]; other site 746361007115 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 746361007116 B3/4 domain; Region: B3_4; pfam03483 746361007117 TRAM domain; Region: TRAM; pfam01938 746361007118 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 746361007119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746361007120 S-adenosylmethionine binding site [chemical binding]; other site 746361007121 legume lectins; Region: lectin_L-type; cd01951 746361007122 homotetramer interaction site [polypeptide binding]; other site 746361007123 carbohydrate binding site [chemical binding]; other site 746361007124 metal binding site [ion binding]; metal-binding site 746361007125 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 746361007126 MucBP domain; Region: MucBP; pfam06458 746361007127 MucBP domain; Region: MucBP; pfam06458 746361007128 MucBP domain; Region: MucBP; pfam06458 746361007129 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 746361007130 recombination regulator RecX; Provisional; Region: recX; PRK14135 746361007131 fructuronate transporter; Provisional; Region: PRK10034; cl15264 746361007132 GntP family permease; Region: GntP_permease; pfam02447 746361007133 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 746361007134 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 746361007135 N- and C-terminal domain interface [polypeptide binding]; other site 746361007136 active site 746361007137 catalytic site [active] 746361007138 metal binding site [ion binding]; metal-binding site 746361007139 carbohydrate binding site [chemical binding]; other site 746361007140 ATP binding site [chemical binding]; other site 746361007141 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 746361007142 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 746361007143 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 746361007144 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 746361007145 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 746361007146 putative active site [active] 746361007147 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 746361007148 phosphodiesterase YaeI; Provisional; Region: PRK11340 746361007149 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 746361007150 putative active site [active] 746361007151 putative metal binding site [ion binding]; other site 746361007152 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 746361007153 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 746361007154 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 746361007155 dimer interface [polypeptide binding]; other site 746361007156 ssDNA binding site [nucleotide binding]; other site 746361007157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361007158 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 746361007159 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 746361007160 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 746361007161 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 746361007162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361007163 Walker A motif; other site 746361007164 ATP binding site [chemical binding]; other site 746361007165 Walker B motif; other site 746361007166 arginine finger; other site 746361007167 Phosphotransferase enzyme family; Region: APH; pfam01636 746361007168 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 746361007169 substrate binding site [chemical binding]; other site 746361007170 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 746361007171 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 746361007172 hypothetical protein; Provisional; Region: PRK07248 746361007173 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 746361007174 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 746361007175 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 746361007176 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 746361007177 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 746361007178 DNA binding residues [nucleotide binding] 746361007179 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 746361007180 Low molecular weight phosphatase family; Region: LMWPc; cd00115 746361007181 active site 746361007182 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 746361007183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746361007184 Walker A motif; other site 746361007185 ATP binding site [chemical binding]; other site 746361007186 Walker B motif; other site 746361007187 arginine finger; other site 746361007188 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 746361007189 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 746361007190 RuvA N terminal domain; Region: RuvA_N; pfam01330 746361007191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 746361007192 helix-hairpin-helix signature motif; other site 746361007193 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 746361007194 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 746361007195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746361007196 ATP binding site [chemical binding]; other site 746361007197 Mg2+ binding site [ion binding]; other site 746361007198 G-X-G motif; other site 746361007199 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 746361007200 ATP binding site [chemical binding]; other site 746361007201 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 746361007202 Protein of unknown function (DUF805); Region: DUF805; pfam05656 746361007203 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 746361007204 MutS domain I; Region: MutS_I; pfam01624 746361007205 MutS domain II; Region: MutS_II; pfam05188 746361007206 MutS domain III; Region: MutS_III; pfam05192 746361007207 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 746361007208 Walker A/P-loop; other site 746361007209 ATP binding site [chemical binding]; other site 746361007210 Q-loop/lid; other site 746361007211 ABC transporter signature motif; other site 746361007212 Walker B; other site 746361007213 D-loop; other site 746361007214 H-loop/switch region; other site 746361007215 Predicted membrane protein [Function unknown]; Region: COG4550 746361007216 Transposase, Mutator family; Region: Transposase_mut; pfam00872 746361007217 MULE transposase domain; Region: MULE; pfam10551 746361007218 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 746361007219 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 746361007220 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 746361007221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 746361007222 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 746361007223 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 746361007224 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 746361007225 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 746361007226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361007227 active site 746361007228 motif I; other site 746361007229 motif II; other site 746361007230 chaperone protein DnaJ; Provisional; Region: PRK14276 746361007231 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746361007232 HSP70 interaction site [polypeptide binding]; other site 746361007233 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 746361007234 substrate binding site [polypeptide binding]; other site 746361007235 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 746361007236 Zn binding sites [ion binding]; other site 746361007237 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 746361007238 substrate binding site [polypeptide binding]; other site 746361007239 dimer interface [polypeptide binding]; other site 746361007240 potential frameshift: common BLAST hit: gi|281492903|ref|YP_003354883.1| Hypothetical protein, extracellular 746361007241 aspartate racemase; Region: asp_race; TIGR00035 746361007242 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 746361007243 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 746361007244 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 746361007245 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 746361007246 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 746361007247 active site 746361007248 dimer interface [polypeptide binding]; other site 746361007249 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746361007250 Ligand Binding Site [chemical binding]; other site 746361007251 Molecular Tunnel; other site 746361007252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 746361007253 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 746361007254 Surface antigen [General function prediction only]; Region: COG3942 746361007255 CHAP domain; Region: CHAP; pfam05257 746361007256 rod shape-determining protein MreD; Region: MreD; pfam04093 746361007257 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 746361007258 rod shape-determining protein MreC; Region: MreC; pfam04085 746361007259 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 746361007260 nudix motif; other site 746361007261 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 746361007262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746361007263 active site 746361007264 dimer interface [polypeptide binding]; other site 746361007265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746361007266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746361007267 ligand binding site [chemical binding]; other site 746361007268 flexible hinge region; other site 746361007269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 746361007270 putative switch regulator; other site 746361007271 non-specific DNA interactions [nucleotide binding]; other site 746361007272 DNA binding site [nucleotide binding] 746361007273 sequence specific DNA binding site [nucleotide binding]; other site 746361007274 putative cAMP binding site [chemical binding]; other site 746361007275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746361007276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746361007277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746361007278 Ligand Binding Site [chemical binding]; other site 746361007279 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 746361007280 nucleotide binding site [chemical binding]; other site 746361007281 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 746361007282 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 746361007283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 746361007284 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 746361007285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 746361007286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361007287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361007288 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 746361007289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746361007290 RNA binding surface [nucleotide binding]; other site 746361007291 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 746361007292 active site 746361007293 uracil binding [chemical binding]; other site 746361007294 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 746361007295 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 746361007296 trmE is a tRNA modification GTPase; Region: trmE; cd04164 746361007297 G1 box; other site 746361007298 GTP/Mg2+ binding site [chemical binding]; other site 746361007299 Switch I region; other site 746361007300 G2 box; other site 746361007301 Switch II region; other site 746361007302 G3 box; other site 746361007303 G4 box; other site 746361007304 G5 box; other site 746361007305 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 746361007306 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 746361007307 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 746361007308 generic binding surface II; other site 746361007309 ssDNA binding site; other site 746361007310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746361007311 ATP binding site [chemical binding]; other site 746361007312 putative Mg++ binding site [ion binding]; other site 746361007313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746361007314 nucleotide binding region [chemical binding]; other site 746361007315 ATP-binding site [chemical binding]; other site 746361007316 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 746361007317 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 746361007318 PhnA protein; Region: PhnA; pfam03831 746361007319 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 746361007320 Int/Topo IB signature motif; other site 746361007321 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 746361007322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746361007323 non-specific DNA binding site [nucleotide binding]; other site 746361007324 salt bridge; other site 746361007325 sequence-specific DNA binding site [nucleotide binding]; other site 746361007326 BRO family, N-terminal domain; Region: Bro-N; smart01040 746361007327 Glucuronate isomerase; Region: UxaC; cl00829 746361007328 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 746361007329 polymerase nucleotide-binding site; other site 746361007330 DNA-binding residues [nucleotide binding]; DNA binding site 746361007331 nucleotide binding site [chemical binding]; other site 746361007332 primase nucleotide-binding site [nucleotide binding]; other site 746361007333 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 746361007334 Phage associated DNA primase [General function prediction only]; Region: COG3378 746361007335 D5 N terminal like; Region: D5_N; smart00885 746361007336 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 746361007337 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 746361007338 Protein of unknown function (DUF722); Region: DUF722; pfam05263 746361007339 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746361007340 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 746361007341 DNA binding residues [nucleotide binding] 746361007342 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 746361007343 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 746361007344 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 746361007345 seryl-tRNA synthetase; Region: serS; TIGR00414 746361007346 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 746361007347 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 746361007348 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746361007349 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 746361007350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746361007351 motif II; other site 746361007352 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 746361007353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746361007354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746361007355 oxidoreductase; Provisional; Region: PRK06196 746361007356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746361007357 NAD(P) binding site [chemical binding]; other site 746361007358 active site 746361007359 potential protein location (hypothetical protein LLNZ_13145 [Lactococcus lactis subsp. cremoris NZ9000]) that overlaps RNA (5S ribosomal RNA) 746361007360 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 746361007361 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 746361007362 23S rRNA interface [nucleotide binding]; other site 746361007363 L3 interface [polypeptide binding]; other site 746361007364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746361007365 FtsX-like permease family; Region: FtsX; pfam02687 746361007366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746361007367 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746361007368 Walker A/P-loop; other site 746361007369 ATP binding site [chemical binding]; other site 746361007370 Q-loop/lid; other site 746361007371 ABC transporter signature motif; other site 746361007372 Walker B; other site 746361007373 D-loop; other site 746361007374 H-loop/switch region; other site 746361007375 ribonuclease HIII; Provisional; Region: PRK00996 746361007376 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 746361007377 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 746361007378 RNA/DNA hybrid binding site [nucleotide binding]; other site 746361007379 active site 746361007380 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 746361007381 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 746361007382 Catalytic site [active] 746361007383 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 746361007384 pur operon repressor; Provisional; Region: PRK09213 746361007385 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 746361007386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746361007387 active site 746361007388 elongation factor G; Reviewed; Region: PRK00007 746361007389 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 746361007390 G1 box; other site 746361007391 putative GEF interaction site [polypeptide binding]; other site 746361007392 GTP/Mg2+ binding site [chemical binding]; other site 746361007393 Switch I region; other site 746361007394 G2 box; other site 746361007395 G3 box; other site 746361007396 Switch II region; other site 746361007397 G4 box; other site 746361007398 G5 box; other site 746361007399 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 746361007400 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 746361007401 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 746361007402 30S ribosomal protein S7; Validated; Region: PRK05302 746361007403 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 746361007404 S17 interaction site [polypeptide binding]; other site 746361007405 S8 interaction site; other site 746361007406 16S rRNA interaction site [nucleotide binding]; other site 746361007407 streptomycin interaction site [chemical binding]; other site 746361007408 23S rRNA interaction site [nucleotide binding]; other site 746361007409 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 746361007410 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 746361007411 Beta-lactamase; Region: Beta-lactamase; cl17358 746361007412 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 746361007413 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 746361007414 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 746361007415 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242