-- dump date   	20140619_125848
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1234378000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1234378000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1234378000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000004	Walker A motif; other site
1234378000005	ATP binding site [chemical binding]; other site
1234378000006	Walker B motif; other site
1234378000007	arginine finger; other site
1234378000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1234378000009	DnaA box-binding interface [nucleotide binding]; other site
1234378000010	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1234378000011	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1234378000012	RF-1 domain; Region: RF-1; pfam00472
1234378000013	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1234378000014	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1234378000015	S4 domain; Region: S4; pfam01479
1234378000016	RNA binding surface [nucleotide binding]; other site
1234378000017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378000018	S-adenosylmethionine binding site [chemical binding]; other site
1234378000019	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1234378000020	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1234378000021	E-class dimer interface [polypeptide binding]; other site
1234378000022	P-class dimer interface [polypeptide binding]; other site
1234378000023	active site
1234378000024	Cu2+ binding site [ion binding]; other site
1234378000025	Zn2+ binding site [ion binding]; other site
1234378000026	TLC ATP/ADP transporter; Region: TLC; pfam03219
1234378000027	Alphaherpesvirus glycoprotein E; Region: Herpes_gE; pfam02480
1234378000028	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
1234378000029	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1234378000030	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1234378000031	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1234378000032	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1234378000033	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1234378000034	putative acyl-acceptor binding pocket; other site
1234378000035	recombination factor protein RarA; Reviewed; Region: PRK13342
1234378000036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000037	Walker A motif; other site
1234378000038	ATP binding site [chemical binding]; other site
1234378000039	Walker B motif; other site
1234378000040	arginine finger; other site
1234378000041	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1234378000042	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1234378000043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1234378000044	active site
1234378000045	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1234378000046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1234378000047	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1234378000048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378000049	S-adenosylmethionine binding site [chemical binding]; other site
1234378000050	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1234378000051	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1234378000052	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1234378000053	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1234378000054	active site
1234378000055	HIGH motif; other site
1234378000056	nucleotide binding site [chemical binding]; other site
1234378000057	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1234378000058	active site
1234378000059	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1234378000060	HIGH motif; other site
1234378000061	dimer interface [polypeptide binding]; other site
1234378000062	KMSKS motif; other site
1234378000063	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1234378000064	Peptidase family M50; Region: Peptidase_M50; pfam02163
1234378000065	active site
1234378000066	putative substrate binding region [chemical binding]; other site
1234378000067	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1234378000068	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1234378000069	active site
1234378000070	HIGH motif; other site
1234378000071	dimer interface [polypeptide binding]; other site
1234378000072	KMSKS motif; other site
1234378000073	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1234378000074	RNA binding surface [nucleotide binding]; other site
1234378000075	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1234378000076	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1234378000077	DNA binding site [nucleotide binding]
1234378000078	active site
1234378000079	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1234378000080	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1234378000081	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1234378000082	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1234378000083	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1234378000084	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1234378000085	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1234378000086	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1234378000087	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1234378000088	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1234378000089	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1234378000090	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
1234378000091	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1234378000092	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1234378000093	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1234378000094	alanine racemase; Reviewed; Region: alr; PRK00053
1234378000095	active site
1234378000096	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1234378000097	dimer interface [polypeptide binding]; other site
1234378000098	substrate binding site [chemical binding]; other site
1234378000099	catalytic residues [active]
1234378000100	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1234378000101	metal binding site 2 [ion binding]; metal-binding site
1234378000102	putative DNA binding helix; other site
1234378000103	metal binding site 1 [ion binding]; metal-binding site
1234378000104	dimer interface [polypeptide binding]; other site
1234378000105	structural Zn2+ binding site [ion binding]; other site
1234378000106	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378000107	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378000108	putative active site [active]
1234378000109	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1234378000110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1234378000111	non-specific DNA binding site [nucleotide binding]; other site
1234378000112	salt bridge; other site
1234378000113	sequence-specific DNA binding site [nucleotide binding]; other site
1234378000114	Staphylococcal nuclease homologues; Region: SNc; smart00318
1234378000115	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1234378000116	Catalytic site; other site
1234378000117	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
1234378000118	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
1234378000119	Tir chaperone protein (CesT) family; Region: CesT; cl08444
1234378000120	Sulfatase; Region: Sulfatase; pfam00884
1234378000121	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1234378000122	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1234378000123	Protein export membrane protein; Region: SecD_SecF; pfam02355
1234378000124	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1234378000125	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1234378000126	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1234378000127	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1234378000128	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
1234378000129	Family description; Region: UvrD_C_2; pfam13538
1234378000130	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1234378000131	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
1234378000132	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1234378000133	active site
1234378000134	ADP/pyrophosphate binding site [chemical binding]; other site
1234378000135	dimerization interface [polypeptide binding]; other site
1234378000136	allosteric effector site; other site
1234378000137	fructose-1,6-bisphosphate binding site; other site
1234378000138	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1234378000139	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1234378000140	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1234378000141	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1234378000142	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1234378000143	catalytic residue [active]
1234378000144	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1234378000145	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1234378000146	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1234378000147	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1234378000148	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1234378000149	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1234378000150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000151	dimer interface [polypeptide binding]; other site
1234378000152	conserved gate region; other site
1234378000153	putative PBP binding loops; other site
1234378000154	ABC-ATPase subunit interface; other site
1234378000155	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1234378000156	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1234378000157	Walker A/P-loop; other site
1234378000158	ATP binding site [chemical binding]; other site
1234378000159	Q-loop/lid; other site
1234378000160	ABC transporter signature motif; other site
1234378000161	Walker B; other site
1234378000162	D-loop; other site
1234378000163	H-loop/switch region; other site
1234378000164	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1234378000165	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1234378000166	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
1234378000167	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1234378000168	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1234378000169	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1234378000170	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1234378000171	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1234378000172	active site
1234378000173	(T/H)XGH motif; other site
1234378000174	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1234378000175	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1234378000176	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1234378000177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378000178	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1234378000179	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1234378000180	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1234378000181	elongation factor P; Validated; Region: PRK00529
1234378000182	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1234378000183	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1234378000184	RNA binding site [nucleotide binding]; other site
1234378000185	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1234378000186	RNA binding site [nucleotide binding]; other site
1234378000187	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1234378000188	G1 box; other site
1234378000189	GTP/Mg2+ binding site [chemical binding]; other site
1234378000190	Switch I region; other site
1234378000191	G2 box; other site
1234378000192	G3 box; other site
1234378000193	Switch II region; other site
1234378000194	G4 box; other site
1234378000195	G5 box; other site
1234378000196	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1234378000197	active site residue [active]
1234378000198	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1234378000199	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1234378000200	active site
1234378000201	metal binding site [ion binding]; metal-binding site
1234378000202	hexamer interface [polypeptide binding]; other site
1234378000203	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1234378000204	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1234378000205	Walker A/P-loop; other site
1234378000206	ATP binding site [chemical binding]; other site
1234378000207	Q-loop/lid; other site
1234378000208	ABC transporter signature motif; other site
1234378000209	Walker B; other site
1234378000210	D-loop; other site
1234378000211	H-loop/switch region; other site
1234378000212	TOBE domain; Region: TOBE_2; pfam08402
1234378000213	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1234378000214	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1234378000215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000216	dimer interface [polypeptide binding]; other site
1234378000217	conserved gate region; other site
1234378000218	putative PBP binding loops; other site
1234378000219	ABC-ATPase subunit interface; other site
1234378000220	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1234378000221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000222	dimer interface [polypeptide binding]; other site
1234378000223	conserved gate region; other site
1234378000224	putative PBP binding loops; other site
1234378000225	ABC-ATPase subunit interface; other site
1234378000226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1234378000227	NAD(P) binding site [chemical binding]; other site
1234378000228	active site
1234378000229	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1234378000230	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1234378000231	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1234378000232	putative active site [active]
1234378000233	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1234378000234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1234378000235	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1234378000236	Domain of unknown function (DUF386); Region: DUF386; cl01047
1234378000237	acetylornithine aminotransferase; Provisional; Region: PRK02627
1234378000238	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1234378000239	inhibitor-cofactor binding pocket; inhibition site
1234378000240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378000241	catalytic residue [active]
1234378000242	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1234378000243	trimer interface [polypeptide binding]; other site
1234378000244	active site
1234378000245	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1234378000246	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1234378000247	nucleotide binding site [chemical binding]; other site
1234378000248	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1234378000249	enolase; Provisional; Region: eno; PRK00077
1234378000250	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1234378000251	dimer interface [polypeptide binding]; other site
1234378000252	metal binding site [ion binding]; metal-binding site
1234378000253	substrate binding pocket [chemical binding]; other site
1234378000254	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378000255	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378000256	putative active site [active]
1234378000257	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1234378000258	AAA domain; Region: AAA_33; pfam13671
1234378000259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1234378000260	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1234378000261	catalytic core [active]
1234378000262	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1234378000263	Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821
1234378000264	Cl binding site [ion binding]; other site
1234378000265	oligomer interface [polypeptide binding]; other site
1234378000266	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1234378000267	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1234378000268	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1234378000269	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
1234378000270	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1234378000271	DNA polymerase I; Provisional; Region: PRK05755
1234378000272	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1234378000273	active site
1234378000274	metal binding site 1 [ion binding]; metal-binding site
1234378000275	putative 5' ssDNA interaction site; other site
1234378000276	metal binding site 3; metal-binding site
1234378000277	metal binding site 2 [ion binding]; metal-binding site
1234378000278	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1234378000279	putative DNA binding site [nucleotide binding]; other site
1234378000280	putative metal binding site [ion binding]; other site
1234378000281	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1234378000282	active site
1234378000283	DNA binding site [nucleotide binding]
1234378000284	catalytic site [active]
1234378000285	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1234378000286	acetolactate synthase; Reviewed; Region: PRK08322
1234378000287	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1234378000288	PYR/PP interface [polypeptide binding]; other site
1234378000289	dimer interface [polypeptide binding]; other site
1234378000290	TPP binding site [chemical binding]; other site
1234378000291	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1234378000292	putative active site [active]
1234378000293	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1234378000294	TPP-binding site [chemical binding]; other site
1234378000295	dimer interface [polypeptide binding]; other site
1234378000296	Membrane transport protein; Region: Mem_trans; cl09117
1234378000297	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1234378000298	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1234378000299	inhibitor site; inhibition site
1234378000300	active site
1234378000301	dimer interface [polypeptide binding]; other site
1234378000302	catalytic residue [active]
1234378000303	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1234378000304	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1234378000305	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1234378000306	DNA protecting protein DprA; Region: dprA; TIGR00732
1234378000307	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1234378000308	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1234378000309	active site
1234378000310	DNA binding site [nucleotide binding]
1234378000311	Int/Topo IB signature motif; other site
1234378000312	Tim44-like domain; Region: Tim44; pfam04280
1234378000313	GTP-binding protein Der; Reviewed; Region: PRK00093
1234378000314	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1234378000315	G1 box; other site
1234378000316	GTP/Mg2+ binding site [chemical binding]; other site
1234378000317	Switch I region; other site
1234378000318	G2 box; other site
1234378000319	Switch II region; other site
1234378000320	G3 box; other site
1234378000321	G4 box; other site
1234378000322	G5 box; other site
1234378000323	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1234378000324	G1 box; other site
1234378000325	GTP/Mg2+ binding site [chemical binding]; other site
1234378000326	Switch I region; other site
1234378000327	G2 box; other site
1234378000328	G3 box; other site
1234378000329	Switch II region; other site
1234378000330	G4 box; other site
1234378000331	G5 box; other site
1234378000332	seryl-tRNA synthetase; Provisional; Region: PRK05431
1234378000333	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1234378000334	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1234378000335	dimer interface [polypeptide binding]; other site
1234378000336	active site
1234378000337	motif 1; other site
1234378000338	motif 2; other site
1234378000339	motif 3; other site
1234378000340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378000341	TPR motif; other site
1234378000342	TPR repeat; Region: TPR_11; pfam13414
1234378000343	binding surface
1234378000344	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1234378000345	diphthine synthase; Region: dph5; TIGR00522
1234378000346	active site
1234378000347	SAM binding site [chemical binding]; other site
1234378000348	homodimer interface [polypeptide binding]; other site
1234378000349	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1234378000350	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1234378000351	active site
1234378000352	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1234378000353	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1234378000354	active site
1234378000355	substrate binding site [chemical binding]; other site
1234378000356	cosubstrate binding site; other site
1234378000357	catalytic site [active]
1234378000358	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1234378000359	methionine sulfoxide reductase B; Provisional; Region: PRK05508
1234378000360	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1234378000361	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
1234378000362	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1234378000363	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1234378000364	maltose O-acetyltransferase; Provisional; Region: PRK10092
1234378000365	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1234378000366	active site
1234378000367	substrate binding site [chemical binding]; other site
1234378000368	trimer interface [polypeptide binding]; other site
1234378000369	CoA binding site [chemical binding]; other site
1234378000370	chaperone protein DnaJ; Provisional; Region: PRK14299
1234378000371	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1234378000372	HSP70 interaction site [polypeptide binding]; other site
1234378000373	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1234378000374	substrate binding site [polypeptide binding]; other site
1234378000375	dimer interface [polypeptide binding]; other site
1234378000376	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
1234378000377	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
1234378000378	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1234378000379	Clp amino terminal domain; Region: Clp_N; pfam02861
1234378000380	Clp amino terminal domain; Region: Clp_N; pfam02861
1234378000381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000382	Walker A motif; other site
1234378000383	ATP binding site [chemical binding]; other site
1234378000384	Walker B motif; other site
1234378000385	arginine finger; other site
1234378000386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000387	Walker A motif; other site
1234378000388	ATP binding site [chemical binding]; other site
1234378000389	Walker B motif; other site
1234378000390	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1234378000391	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1234378000392	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1234378000393	Walker A/P-loop; other site
1234378000394	ATP binding site [chemical binding]; other site
1234378000395	Q-loop/lid; other site
1234378000396	ABC transporter signature motif; other site
1234378000397	Walker B; other site
1234378000398	D-loop; other site
1234378000399	H-loop/switch region; other site
1234378000400	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1234378000401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000402	dimer interface [polypeptide binding]; other site
1234378000403	conserved gate region; other site
1234378000404	putative PBP binding loops; other site
1234378000405	ABC-ATPase subunit interface; other site
1234378000406	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1234378000407	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1234378000408	substrate binding pocket [chemical binding]; other site
1234378000409	membrane-bound complex binding site; other site
1234378000410	hinge residues; other site
1234378000411	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1234378000412	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1234378000413	active site
1234378000414	motif I; other site
1234378000415	motif II; other site
1234378000416	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1234378000417	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1234378000418	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
1234378000419	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1234378000420	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1234378000421	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1234378000422	catalytic residue [active]
1234378000423	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1234378000424	anti sigma factor interaction site; other site
1234378000425	regulatory phosphorylation site [posttranslational modification]; other site
1234378000426	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1234378000427	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1234378000428	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1234378000429	HD domain; Region: HD_3; pfam13023
1234378000430	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1234378000431	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
1234378000432	YtxH-like protein; Region: YtxH; cl02079
1234378000433	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1234378000434	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1234378000435	Probable Catalytic site; other site
1234378000436	metal-binding site
1234378000437	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1234378000438	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1234378000439	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1234378000440	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1234378000441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378000442	S-adenosylmethionine binding site [chemical binding]; other site
1234378000443	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1234378000444	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1234378000445	G1 box; other site
1234378000446	putative GEF interaction site [polypeptide binding]; other site
1234378000447	GTP/Mg2+ binding site [chemical binding]; other site
1234378000448	Switch I region; other site
1234378000449	G2 box; other site
1234378000450	G3 box; other site
1234378000451	Switch II region; other site
1234378000452	G4 box; other site
1234378000453	G5 box; other site
1234378000454	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1234378000455	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1234378000456	GTP-binding protein YchF; Reviewed; Region: PRK09601
1234378000457	YchF GTPase; Region: YchF; cd01900
1234378000458	G1 box; other site
1234378000459	GTP/Mg2+ binding site [chemical binding]; other site
1234378000460	Switch I region; other site
1234378000461	G2 box; other site
1234378000462	Switch II region; other site
1234378000463	G3 box; other site
1234378000464	G4 box; other site
1234378000465	G5 box; other site
1234378000466	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1234378000467	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1234378000468	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1234378000469	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1234378000470	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000471	Walker A motif; other site
1234378000472	ATP binding site [chemical binding]; other site
1234378000473	Walker B motif; other site
1234378000474	arginine finger; other site
1234378000475	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1234378000476	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
1234378000477	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1234378000478	MPN+ (JAMM) motif; other site
1234378000479	Zinc-binding site [ion binding]; other site
1234378000480	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
1234378000481	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1234378000482	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1234378000483	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1234378000484	HIGH motif; other site
1234378000485	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1234378000486	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1234378000487	active site
1234378000488	KMSKS motif; other site
1234378000489	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1234378000490	tRNA binding surface [nucleotide binding]; other site
1234378000491	transcription antitermination factor NusB; Region: nusB; TIGR01951
1234378000492	putative RNA binding site [nucleotide binding]; other site
1234378000493	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1234378000494	homopentamer interface [polypeptide binding]; other site
1234378000495	active site
1234378000496	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1234378000497	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1234378000498	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1234378000499	dimerization interface [polypeptide binding]; other site
1234378000500	active site
1234378000501	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1234378000502	Lumazine binding domain; Region: Lum_binding; pfam00677
1234378000503	Lumazine binding domain; Region: Lum_binding; pfam00677
1234378000504	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1234378000505	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1234378000506	catalytic motif [active]
1234378000507	Zn binding site [ion binding]; other site
1234378000508	RibD C-terminal domain; Region: RibD_C; cl17279
1234378000509	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1234378000510	catalytic motif [active]
1234378000511	Zn binding site [ion binding]; other site
1234378000512	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1234378000513	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1234378000514	dimer interface [polypeptide binding]; other site
1234378000515	active site
1234378000516	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1234378000517	folate binding site [chemical binding]; other site
1234378000518	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1234378000519	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1234378000520	dimer interface [polypeptide binding]; other site
1234378000521	active site
1234378000522	acyl carrier protein; Provisional; Region: acpP; PRK00982
1234378000523	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1234378000524	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1234378000525	NAD(P) binding site [chemical binding]; other site
1234378000526	homotetramer interface [polypeptide binding]; other site
1234378000527	homodimer interface [polypeptide binding]; other site
1234378000528	active site
1234378000529	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1234378000530	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1234378000531	dimer interface [polypeptide binding]; other site
1234378000532	active site
1234378000533	CoA binding pocket [chemical binding]; other site
1234378000534	putative phosphate acyltransferase; Provisional; Region: PRK05331
1234378000535	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1234378000536	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1234378000537	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1234378000538	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1234378000539	minor groove reading motif; other site
1234378000540	helix-hairpin-helix signature motif; other site
1234378000541	substrate binding pocket [chemical binding]; other site
1234378000542	active site
1234378000543	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1234378000544	active site
1234378000545	8-oxo-dGMP binding site [chemical binding]; other site
1234378000546	nudix motif; other site
1234378000547	metal binding site [ion binding]; metal-binding site
1234378000548	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1234378000549	substrate binding site [chemical binding]; other site
1234378000550	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1234378000551	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1234378000552	substrate binding site [chemical binding]; other site
1234378000553	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1234378000554	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1234378000555	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1234378000556	ATP binding site [chemical binding]; other site
1234378000557	putative Mg++ binding site [ion binding]; other site
1234378000558	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1234378000559	nucleotide binding region [chemical binding]; other site
1234378000560	ATP-binding site [chemical binding]; other site
1234378000561	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1234378000562	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
1234378000563	peptide binding site [polypeptide binding]; other site
1234378000564	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1234378000565	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378000566	Zn2+ binding site [ion binding]; other site
1234378000567	Mg2+ binding site [ion binding]; other site
1234378000568	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1234378000569	synthetase active site [active]
1234378000570	NTP binding site [chemical binding]; other site
1234378000571	metal binding site [ion binding]; metal-binding site
1234378000572	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1234378000573	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1234378000574	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1234378000575	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1234378000576	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1234378000577	active site
1234378000578	DNA binding site [nucleotide binding]
1234378000579	Int/Topo IB signature motif; other site
1234378000580	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
1234378000581	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1234378000582	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1234378000583	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1234378000584	G1 box; other site
1234378000585	putative GEF interaction site [polypeptide binding]; other site
1234378000586	GTP/Mg2+ binding site [chemical binding]; other site
1234378000587	Switch I region; other site
1234378000588	G2 box; other site
1234378000589	G3 box; other site
1234378000590	Switch II region; other site
1234378000591	G4 box; other site
1234378000592	G5 box; other site
1234378000593	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1234378000594	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1234378000595	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1234378000596	Endonuclease I; Region: Endonuclease_1; pfam04231
1234378000597	ERF superfamily; Region: ERF; pfam04404
1234378000598	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1234378000599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000600	Walker A motif; other site
1234378000601	ATP binding site [chemical binding]; other site
1234378000602	Walker B motif; other site
1234378000603	arginine finger; other site
1234378000604	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1234378000605	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
1234378000606	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1234378000607	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1234378000608	metal ion-dependent adhesion site (MIDAS); other site
1234378000609	FtsH Extracellular; Region: FtsH_ext; pfam06480
1234378000610	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1234378000611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000612	Walker A motif; other site
1234378000613	ATP binding site [chemical binding]; other site
1234378000614	Walker B motif; other site
1234378000615	arginine finger; other site
1234378000616	Peptidase family M41; Region: Peptidase_M41; pfam01434
1234378000617	dihydropteroate synthase; Region: DHPS; TIGR01496
1234378000618	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1234378000619	substrate binding pocket [chemical binding]; other site
1234378000620	dimer interface [polypeptide binding]; other site
1234378000621	inhibitor binding site; inhibition site
1234378000622	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1234378000623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1234378000624	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
1234378000625	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1234378000626	active site
1234378000627	substrate binding site [chemical binding]; other site
1234378000628	metal binding site [ion binding]; metal-binding site
1234378000629	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1234378000630	active site
1234378000631	tetramer interface; other site
1234378000632	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1234378000633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1234378000634	ATP binding site [chemical binding]; other site
1234378000635	putative Mg++ binding site [ion binding]; other site
1234378000636	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1234378000637	ATP-binding site [chemical binding]; other site
1234378000638	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1234378000639	Predicted permease [General function prediction only]; Region: COG2985
1234378000640	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1234378000641	TrkA-C domain; Region: TrkA_C; pfam02080
1234378000642	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1234378000643	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1234378000644	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1234378000645	membrane protein; Provisional; Region: PRK14397
1234378000646	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1234378000647	RNB domain; Region: RNB; pfam00773
1234378000648	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1234378000649	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1234378000650	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1234378000651	GDP-binding site [chemical binding]; other site
1234378000652	ACT binding site; other site
1234378000653	IMP binding site; other site
1234378000654	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1234378000655	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1234378000656	Ligand Binding Site [chemical binding]; other site
1234378000657	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
1234378000658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378000659	FeS/SAM binding site; other site
1234378000660	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1234378000661	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1234378000662	dimer interface [polypeptide binding]; other site
1234378000663	active site
1234378000664	Schiff base residues; other site
1234378000665	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
1234378000666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378000667	FeS/SAM binding site; other site
1234378000668	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1234378000669	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1234378000670	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1234378000671	Flagellar protein FliS; Region: FliS; cl00654
1234378000672	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1234378000673	flagellar capping protein; Provisional; Region: PRK12765
1234378000674	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1234378000675	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1234378000676	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1234378000677	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1234378000678	active site
1234378000679	dimer interface [polypeptide binding]; other site
1234378000680	motif 1; other site
1234378000681	motif 2; other site
1234378000682	motif 3; other site
1234378000683	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1234378000684	anticodon binding site; other site
1234378000685	translation initiation factor IF-3; Region: infC; TIGR00168
1234378000686	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1234378000687	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1234378000688	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1234378000689	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1234378000690	23S rRNA binding site [nucleotide binding]; other site
1234378000691	L21 binding site [polypeptide binding]; other site
1234378000692	L13 binding site [polypeptide binding]; other site
1234378000693	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1234378000694	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1234378000695	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1234378000696	dimer interface [polypeptide binding]; other site
1234378000697	motif 1; other site
1234378000698	active site
1234378000699	motif 2; other site
1234378000700	motif 3; other site
1234378000701	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1234378000702	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1234378000703	putative tRNA-binding site [nucleotide binding]; other site
1234378000704	B3/4 domain; Region: B3_4; pfam03483
1234378000705	tRNA synthetase B5 domain; Region: B5; smart00874
1234378000706	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1234378000707	dimer interface [polypeptide binding]; other site
1234378000708	motif 1; other site
1234378000709	motif 3; other site
1234378000710	motif 2; other site
1234378000711	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1234378000712	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1234378000713	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1234378000714	DNA binding residues [nucleotide binding]
1234378000715	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1234378000716	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1234378000717	substrate binding site [chemical binding]; other site
1234378000718	hexamer interface [polypeptide binding]; other site
1234378000719	metal binding site [ion binding]; metal-binding site
1234378000720	transketolase; Reviewed; Region: PRK12753
1234378000721	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1234378000722	TPP-binding site [chemical binding]; other site
1234378000723	dimer interface [polypeptide binding]; other site
1234378000724	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1234378000725	PYR/PP interface [polypeptide binding]; other site
1234378000726	dimer interface [polypeptide binding]; other site
1234378000727	TPP binding site [chemical binding]; other site
1234378000728	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1234378000729	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1234378000730	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
1234378000731	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1234378000732	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1234378000733	RNA/DNA hybrid binding site [nucleotide binding]; other site
1234378000734	active site
1234378000735	hypothetical protein; Provisional; Region: PRK14680
1234378000736	Predicted methyltransferases [General function prediction only]; Region: COG0313
1234378000737	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1234378000738	putative SAM binding site [chemical binding]; other site
1234378000739	putative homodimer interface [polypeptide binding]; other site
1234378000740	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1234378000741	SmpB-tmRNA interface; other site
1234378000742	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1234378000743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378000744	Walker A/P-loop; other site
1234378000745	ATP binding site [chemical binding]; other site
1234378000746	Q-loop/lid; other site
1234378000747	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1234378000748	ABC transporter; Region: ABC_tran_2; pfam12848
1234378000749	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1234378000750	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1234378000751	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1234378000752	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1234378000753	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1234378000754	putative active site [active]
1234378000755	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1234378000756	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1234378000757	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1234378000758	active site
1234378000759	HIGH motif; other site
1234378000760	KMSK motif region; other site
1234378000761	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1234378000762	tRNA binding surface [nucleotide binding]; other site
1234378000763	anticodon binding site; other site
1234378000764	Sporulation related domain; Region: SPOR; pfam05036
1234378000765	Permease; Region: Permease; pfam02405
1234378000766	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1234378000767	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1234378000768	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1234378000769	Walker A/P-loop; other site
1234378000770	ATP binding site [chemical binding]; other site
1234378000771	Q-loop/lid; other site
1234378000772	ABC transporter signature motif; other site
1234378000773	Walker B; other site
1234378000774	D-loop; other site
1234378000775	H-loop/switch region; other site
1234378000776	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1234378000777	mce related protein; Region: MCE; pfam02470
1234378000778	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1234378000779	VacJ like lipoprotein; Region: VacJ; cl01073
1234378000780	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1234378000781	MutS domain I; Region: MutS_I; pfam01624
1234378000782	MutS domain II; Region: MutS_II; pfam05188
1234378000783	MutS domain III; Region: MutS_III; pfam05192
1234378000784	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1234378000785	Walker A/P-loop; other site
1234378000786	ATP binding site [chemical binding]; other site
1234378000787	Q-loop/lid; other site
1234378000788	ABC transporter signature motif; other site
1234378000789	Walker B; other site
1234378000790	D-loop; other site
1234378000791	H-loop/switch region; other site
1234378000792	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1234378000793	nucleotide binding site/active site [active]
1234378000794	HIT family signature motif; other site
1234378000795	catalytic residue [active]
1234378000796	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1234378000797	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1234378000798	active site
1234378000799	NTP binding site [chemical binding]; other site
1234378000800	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1234378000801	metal binding triad [ion binding]; metal-binding site
1234378000802	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1234378000803	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1234378000804	active site
1234378000805	DNA binding site [nucleotide binding]
1234378000806	Int/Topo IB signature motif; other site
1234378000807	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1234378000808	catalytic center binding site [active]
1234378000809	ATP binding site [chemical binding]; other site
1234378000810	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
1234378000811	excinuclease ABC subunit B; Provisional; Region: PRK05298
1234378000812	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1234378000813	ATP binding site [chemical binding]; other site
1234378000814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1234378000815	nucleotide binding region [chemical binding]; other site
1234378000816	ATP-binding site [chemical binding]; other site
1234378000817	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1234378000818	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1234378000819	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1234378000820	nucleotide binding pocket [chemical binding]; other site
1234378000821	K-X-D-G motif; other site
1234378000822	catalytic site [active]
1234378000823	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1234378000824	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1234378000825	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1234378000826	Dimer interface [polypeptide binding]; other site
1234378000827	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1234378000828	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1234378000829	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1234378000830	NAD synthetase; Provisional; Region: PRK13981
1234378000831	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1234378000832	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1234378000833	homodimer interface [polypeptide binding]; other site
1234378000834	NAD binding pocket [chemical binding]; other site
1234378000835	ATP binding pocket [chemical binding]; other site
1234378000836	Mg binding site [ion binding]; other site
1234378000837	active-site loop [active]
1234378000838	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1234378000839	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1234378000840	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1234378000841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378000842	TPR motif; other site
1234378000843	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1234378000844	binding surface
1234378000845	AMIN domain; Region: AMIN; pfam11741
1234378000846	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1234378000847	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1234378000848	Walker A/P-loop; other site
1234378000849	ATP binding site [chemical binding]; other site
1234378000850	Q-loop/lid; other site
1234378000851	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1234378000852	ABC transporter signature motif; other site
1234378000853	Walker B; other site
1234378000854	D-loop; other site
1234378000855	H-loop/switch region; other site
1234378000856	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1234378000857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000858	dimer interface [polypeptide binding]; other site
1234378000859	conserved gate region; other site
1234378000860	putative PBP binding loops; other site
1234378000861	ABC-ATPase subunit interface; other site
1234378000862	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1234378000863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378000864	dimer interface [polypeptide binding]; other site
1234378000865	conserved gate region; other site
1234378000866	putative PBP binding loops; other site
1234378000867	ABC-ATPase subunit interface; other site
1234378000868	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
1234378000869	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378000870	Zn2+ binding site [ion binding]; other site
1234378000871	Mg2+ binding site [ion binding]; other site
1234378000872	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1234378000873	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1234378000874	active site
1234378000875	PHP Thumb interface [polypeptide binding]; other site
1234378000876	metal binding site [ion binding]; metal-binding site
1234378000877	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1234378000878	generic binding surface I; other site
1234378000879	generic binding surface II; other site
1234378000880	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1234378000881	active site
1234378000882	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1234378000883	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1234378000884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1234378000885	dimerization interface [polypeptide binding]; other site
1234378000886	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1234378000887	putative active site [active]
1234378000888	heme pocket [chemical binding]; other site
1234378000889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1234378000890	dimer interface [polypeptide binding]; other site
1234378000891	phosphorylation site [posttranslational modification]
1234378000892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378000893	ATP binding site [chemical binding]; other site
1234378000894	Mg2+ binding site [ion binding]; other site
1234378000895	G-X-G motif; other site
1234378000896	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1234378000897	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
1234378000898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378000899	catalytic residue [active]
1234378000900	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
1234378000901	amino acid transporter; Region: 2A0306; TIGR00909
1234378000902	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1234378000903	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1234378000904	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1234378000905	RNA binding site [nucleotide binding]; other site
1234378000906	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1234378000907	multimer interface [polypeptide binding]; other site
1234378000908	Walker A motif; other site
1234378000909	ATP binding site [chemical binding]; other site
1234378000910	Walker B motif; other site
1234378000911	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1234378000912	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1234378000913	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1234378000914	catalytic residue [active]
1234378000915	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
1234378000916	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1234378000917	trimerization site [polypeptide binding]; other site
1234378000918	active site
1234378000919	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1234378000920	NifU-like domain; Region: NifU; cl00484
1234378000921	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1234378000922	active site
1234378000923	putative DNA-binding cleft [nucleotide binding]; other site
1234378000924	dimer interface [polypeptide binding]; other site
1234378000925	hypothetical protein; Validated; Region: PRK00110
1234378000926	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1234378000927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378000928	S-adenosylmethionine binding site [chemical binding]; other site
1234378000929	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1234378000930	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1234378000931	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
1234378000932	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
1234378000933	non-heme iron binding site [ion binding]; other site
1234378000934	dimer interface [polypeptide binding]; other site
1234378000935	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
1234378000936	non-heme iron binding site [ion binding]; other site
1234378000937	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1234378000938	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1234378000939	Flavodoxin; Region: Flavodoxin_1; pfam00258
1234378000940	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1234378000941	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1234378000942	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1234378000943	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
1234378000944	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1234378000945	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1234378000946	dimer interface [polypeptide binding]; other site
1234378000947	PYR/PP interface [polypeptide binding]; other site
1234378000948	TPP binding site [chemical binding]; other site
1234378000949	substrate binding site [chemical binding]; other site
1234378000950	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1234378000951	Domain of unknown function; Region: EKR; smart00890
1234378000952	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1234378000953	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1234378000954	TPP-binding site [chemical binding]; other site
1234378000955	dimer interface [polypeptide binding]; other site
1234378000956	phosphate acetyltransferase; Reviewed; Region: PRK05632
1234378000957	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1234378000958	DRTGG domain; Region: DRTGG; pfam07085
1234378000959	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1234378000960	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1234378000961	propionate/acetate kinase; Provisional; Region: PRK12379
1234378000962	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1234378000963	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1234378000964	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1234378000965	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1234378000966	active site
1234378000967	(T/H)XGH motif; other site
1234378000968	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1234378000969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378000970	S-adenosylmethionine binding site [chemical binding]; other site
1234378000971	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1234378000972	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1234378000973	Beta-Casp domain; Region: Beta-Casp; smart01027
1234378000974	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1234378000975	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
1234378000976	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1234378000977	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1234378000978	NlpC/P60 family; Region: NLPC_P60; cl17555
1234378000979	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
1234378000980	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1234378000981	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
1234378000982	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1234378000983	NlpC/P60 family; Region: NLPC_P60; cl17555
1234378000984	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1234378000985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378000986	Walker A motif; other site
1234378000987	ATP binding site [chemical binding]; other site
1234378000988	Walker B motif; other site
1234378000989	Family description; Region: UvrD_C_2; pfam13538
1234378000990	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
1234378000991	active site
1234378000992	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1234378000993	Pirin-related protein [General function prediction only]; Region: COG1741
1234378000994	Pirin; Region: Pirin; pfam02678
1234378000995	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1234378000996	hypothetical protein; Provisional; Region: PRK07208
1234378000997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1234378000998	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1234378000999	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1234378001000	Fumarase C-terminus; Region: Fumerase_C; cl00795
1234378001001	fumarate hydratase; Provisional; Region: PRK06246
1234378001002	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1234378001003	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1234378001004	dimerization interface [polypeptide binding]; other site
1234378001005	putative ATP binding site [chemical binding]; other site
1234378001006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1234378001007	Smr domain; Region: Smr; pfam01713
1234378001008	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1234378001009	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1234378001010	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1234378001011	dimer interface [polypeptide binding]; other site
1234378001012	motif 1; other site
1234378001013	active site
1234378001014	motif 2; other site
1234378001015	motif 3; other site
1234378001016	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1234378001017	Recombination protein O N terminal; Region: RecO_N; pfam11967
1234378001018	Recombination protein O C terminal; Region: RecO_C; pfam02565
1234378001019	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1234378001020	Helix-turn-helix domain; Region: HTH_25; pfam13413
1234378001021	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1234378001022	SurA N-terminal domain; Region: SurA_N_3; cl07813
1234378001023	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1234378001024	SurA N-terminal domain; Region: SurA_N_3; cl07813
1234378001025	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1234378001026	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1234378001027	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1234378001028	ATP binding site [chemical binding]; other site
1234378001029	putative Mg++ binding site [ion binding]; other site
1234378001030	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1234378001031	nucleotide binding region [chemical binding]; other site
1234378001032	ATP-binding site [chemical binding]; other site
1234378001033	TRCF domain; Region: TRCF; pfam03461
1234378001034	Predicted integral membrane protein [Function unknown]; Region: COG0392
1234378001035	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1234378001036	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1234378001037	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1234378001038	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1234378001039	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1234378001040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378001041	FeS/SAM binding site; other site
1234378001042	hypothetical protein; Provisional; Region: PRK11820
1234378001043	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1234378001044	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1234378001045	hypothetical protein; Provisional; Region: PRK04323
1234378001046	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1234378001047	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1234378001048	catalytic site [active]
1234378001049	G-X2-G-X-G-K; other site
1234378001050	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1234378001051	active site
1234378001052	dimer interface [polypeptide binding]; other site
1234378001053	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1234378001054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378001055	binding surface
1234378001056	TPR motif; other site
1234378001057	TPR repeat; Region: TPR_11; pfam13414
1234378001058	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1234378001059	DHH family; Region: DHH; pfam01368
1234378001060	DHHA1 domain; Region: DHHA1; pfam02272
1234378001061	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1234378001062	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1234378001063	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1234378001064	active site
1234378001065	CoA binding domain; Region: CoA_binding; cl17356
1234378001066	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1234378001067	HSP70 interaction site [polypeptide binding]; other site
1234378001068	adenylate kinase; Provisional; Region: PRK14529
1234378001069	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1234378001070	AMP-binding site [chemical binding]; other site
1234378001071	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1234378001072	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1234378001073	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1234378001074	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378001075	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378001076	putative active site [active]
1234378001077	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
1234378001078	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1234378001079	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1234378001080	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1234378001081	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1234378001082	tRNA; other site
1234378001083	putative tRNA binding site [nucleotide binding]; other site
1234378001084	putative NADP binding site [chemical binding]; other site
1234378001085	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1234378001086	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1234378001087	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1234378001088	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1234378001089	P loop; other site
1234378001090	GTP binding site [chemical binding]; other site
1234378001091	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1234378001092	thiamine phosphate binding site [chemical binding]; other site
1234378001093	active site
1234378001094	pyrophosphate binding site [ion binding]; other site
1234378001095	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1234378001096	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1234378001097	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1234378001098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001099	S-adenosylmethionine binding site [chemical binding]; other site
1234378001100	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1234378001101	IHF dimer interface [polypeptide binding]; other site
1234378001102	IHF - DNA interface [nucleotide binding]; other site
1234378001103	Protein of unknown function (DUF721); Region: DUF721; pfam05258
1234378001104	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
1234378001105	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
1234378001106	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1234378001107	Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297
1234378001108	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1234378001109	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378001110	N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795
1234378001111	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
1234378001112	putative active site [active]
1234378001113	catalytic site [active]
1234378001114	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1234378001115	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1234378001116	putative homodimer interface [polypeptide binding]; other site
1234378001117	putative active site pocket [active]
1234378001118	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1234378001119	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1234378001120	feedback inhibition sensing region; other site
1234378001121	homohexameric interface [polypeptide binding]; other site
1234378001122	nucleotide binding site [chemical binding]; other site
1234378001123	N-acetyl-L-glutamate binding site [chemical binding]; other site
1234378001124	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1234378001125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378001126	Walker A motif; other site
1234378001127	ATP binding site [chemical binding]; other site
1234378001128	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1234378001129	Walker B motif; other site
1234378001130	arginine finger; other site
1234378001131	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1234378001132	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1234378001133	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1234378001134	Walker A/P-loop; other site
1234378001135	ATP binding site [chemical binding]; other site
1234378001136	Q-loop/lid; other site
1234378001137	ABC transporter signature motif; other site
1234378001138	Walker B; other site
1234378001139	D-loop; other site
1234378001140	H-loop/switch region; other site
1234378001141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1234378001142	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1234378001143	Walker A/P-loop; other site
1234378001144	ATP binding site [chemical binding]; other site
1234378001145	Q-loop/lid; other site
1234378001146	ABC transporter signature motif; other site
1234378001147	Walker B; other site
1234378001148	D-loop; other site
1234378001149	H-loop/switch region; other site
1234378001150	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1234378001151	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1234378001152	TM-ABC transporter signature motif; other site
1234378001153	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1234378001154	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1234378001155	TM-ABC transporter signature motif; other site
1234378001156	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1234378001157	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1234378001158	dimerization interface [polypeptide binding]; other site
1234378001159	ligand binding site [chemical binding]; other site
1234378001160	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
1234378001161	Yip1 domain; Region: Yip1; pfam04893
1234378001162	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
1234378001163	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1234378001164	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1234378001165	nucleoside/Zn binding site; other site
1234378001166	dimer interface [polypeptide binding]; other site
1234378001167	catalytic motif [active]
1234378001168	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1234378001169	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001170	S-adenosylmethionine binding site [chemical binding]; other site
1234378001171	HupF/HypC family; Region: HupF_HypC; pfam01455
1234378001172	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1234378001173	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1234378001174	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1234378001175	protein binding site [polypeptide binding]; other site
1234378001176	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1234378001177	protein binding site [polypeptide binding]; other site
1234378001178	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1234378001179	Transglycosylase; Region: Transgly; pfam00912
1234378001180	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1234378001181	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1234378001182	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1234378001183	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1234378001184	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1234378001185	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1234378001186	ATP binding site [chemical binding]; other site
1234378001187	active site
1234378001188	substrate binding site [chemical binding]; other site
1234378001189	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1234378001190	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1234378001191	NAD binding site [chemical binding]; other site
1234378001192	homotetramer interface [polypeptide binding]; other site
1234378001193	homodimer interface [polypeptide binding]; other site
1234378001194	substrate binding site [chemical binding]; other site
1234378001195	active site
1234378001196	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1234378001197	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1234378001198	putative NAD(P) binding site [chemical binding]; other site
1234378001199	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1234378001200	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1234378001201	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1234378001202	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1234378001203	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1234378001204	replicative DNA helicase; Region: DnaB; TIGR00665
1234378001205	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1234378001206	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1234378001207	Walker A motif; other site
1234378001208	ATP binding site [chemical binding]; other site
1234378001209	Walker B motif; other site
1234378001210	DNA binding loops [nucleotide binding]
1234378001211	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1234378001212	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1234378001213	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1234378001214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378001215	Walker A/P-loop; other site
1234378001216	ATP binding site [chemical binding]; other site
1234378001217	Q-loop/lid; other site
1234378001218	ABC transporter signature motif; other site
1234378001219	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1234378001220	Walker B; other site
1234378001221	D-loop; other site
1234378001222	ABC transporter; Region: ABC_tran_2; pfam12848
1234378001223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1234378001224	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1234378001225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001226	S-adenosylmethionine binding site [chemical binding]; other site
1234378001227	AsmA family; Region: AsmA; pfam05170
1234378001228	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1234378001229	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1234378001230	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1234378001231	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1234378001232	Divalent cation transporter; Region: MgtE; pfam01769
1234378001233	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1234378001234	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1234378001235	dimerization interface [polypeptide binding]; other site
1234378001236	active site
1234378001237	quinolinate synthetase; Provisional; Region: PRK09375
1234378001238	L-aspartate oxidase; Region: nadB; TIGR00551
1234378001239	L-aspartate oxidase; Provisional; Region: PRK06175
1234378001240	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1234378001241	YGGT family; Region: YGGT; pfam02325
1234378001242	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1234378001243	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1234378001244	motif II; other site
1234378001245	twin arginine translocase protein A; Provisional; Region: tatA; PRK14859
1234378001246	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1234378001247	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1234378001248	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1234378001249	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1234378001250	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1234378001251	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1234378001252	catalytic residues [active]
1234378001253	UGMP family protein; Validated; Region: PRK09604
1234378001254	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1234378001255	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1234378001256	AMP binding site [chemical binding]; other site
1234378001257	metal binding site [ion binding]; metal-binding site
1234378001258	active site
1234378001259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1234378001260	TPR motif; other site
1234378001261	binding surface
1234378001262	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1234378001263	Septum formation initiator; Region: DivIC; pfam04977
1234378001264	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1234378001265	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1234378001266	Walker A motif; other site
1234378001267	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
1234378001268	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1234378001269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001270	S-adenosylmethionine binding site [chemical binding]; other site
1234378001271	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1234378001272	Peptidase family M23; Region: Peptidase_M23; pfam01551
1234378001273	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1234378001274	rRNA interaction site [nucleotide binding]; other site
1234378001275	S8 interaction site; other site
1234378001276	putative laminin-1 binding site; other site
1234378001277	elongation factor Ts; Provisional; Region: tsf; PRK09377
1234378001278	UBA/TS-N domain; Region: UBA; pfam00627
1234378001279	Elongation factor TS; Region: EF_TS; pfam00889
1234378001280	Elongation factor TS; Region: EF_TS; pfam00889
1234378001281	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1234378001282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1234378001283	NAD(P) binding site [chemical binding]; other site
1234378001284	active site
1234378001285	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1234378001286	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1234378001287	inhibitor-cofactor binding pocket; inhibition site
1234378001288	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378001289	catalytic residue [active]
1234378001290	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1234378001291	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1234378001292	putative metal binding site; other site
1234378001293	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1234378001294	putative nucleotide binding site [chemical binding]; other site
1234378001295	uridine monophosphate binding site [chemical binding]; other site
1234378001296	homohexameric interface [polypeptide binding]; other site
1234378001297	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1234378001298	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1234378001299	hinge region; other site
1234378001300	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1234378001301	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1234378001302	catalytic residue [active]
1234378001303	putative FPP diphosphate  binding site; other site
1234378001304	putative FPP binding hydrophobic cleft; other site
1234378001305	dimer interface [polypeptide binding]; other site
1234378001306	putative IPP diphosphate binding site; other site
1234378001307	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1234378001308	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1234378001309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1234378001310	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1234378001311	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1234378001312	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1234378001313	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1234378001314	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1234378001315	active site
1234378001316	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1234378001317	protein binding site [polypeptide binding]; other site
1234378001318	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1234378001319	putative substrate binding region [chemical binding]; other site
1234378001320	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1234378001321	Glycoprotease family; Region: Peptidase_M22; pfam00814
1234378001322	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1234378001323	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1234378001324	cofactor binding site; other site
1234378001325	DNA binding site [nucleotide binding]
1234378001326	substrate interaction site [chemical binding]; other site
1234378001327	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1234378001328	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1234378001329	dimer interface [polypeptide binding]; other site
1234378001330	motif 1; other site
1234378001331	active site
1234378001332	motif 2; other site
1234378001333	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1234378001334	putative deacylase active site [active]
1234378001335	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1234378001336	active site
1234378001337	motif 3; other site
1234378001338	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1234378001339	anticodon binding site; other site
1234378001340	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1234378001341	rod shape-determining protein MreB; Provisional; Region: PRK13927
1234378001342	MreB and similar proteins; Region: MreB_like; cd10225
1234378001343	nucleotide binding site [chemical binding]; other site
1234378001344	Mg binding site [ion binding]; other site
1234378001345	putative protofilament interaction site [polypeptide binding]; other site
1234378001346	RodZ interaction site [polypeptide binding]; other site
1234378001347	rod shape-determining protein MreC; Provisional; Region: PRK13922
1234378001348	rod shape-determining protein MreC; Region: MreC; pfam04085
1234378001349	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1234378001350	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1234378001351	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1234378001352	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1234378001353	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1234378001354	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
1234378001355	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1234378001356	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1234378001357	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
1234378001358	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
1234378001359	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1234378001360	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1234378001361	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1234378001362	beta subunit interaction interface [polypeptide binding]; other site
1234378001363	Walker A motif; other site
1234378001364	ATP binding site [chemical binding]; other site
1234378001365	Walker B motif; other site
1234378001366	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1234378001367	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1234378001368	core domain interface [polypeptide binding]; other site
1234378001369	delta subunit interface [polypeptide binding]; other site
1234378001370	epsilon subunit interface [polypeptide binding]; other site
1234378001371	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1234378001372	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1234378001373	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1234378001374	alpha subunit interaction interface [polypeptide binding]; other site
1234378001375	Walker A motif; other site
1234378001376	ATP binding site [chemical binding]; other site
1234378001377	Walker B motif; other site
1234378001378	inhibitor binding site; inhibition site
1234378001379	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1234378001380	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
1234378001381	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1234378001382	gamma subunit interface [polypeptide binding]; other site
1234378001383	epsilon subunit interface [polypeptide binding]; other site
1234378001384	LBP interface [polypeptide binding]; other site
1234378001385	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1234378001386	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1234378001387	generic binding surface II; other site
1234378001388	generic binding surface I; other site
1234378001389	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1234378001390	Peptidase family M23; Region: Peptidase_M23; pfam01551
1234378001391	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
1234378001392	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1234378001393	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1234378001394	substrate binding pocket [chemical binding]; other site
1234378001395	chain length determination region; other site
1234378001396	substrate-Mg2+ binding site; other site
1234378001397	catalytic residues [active]
1234378001398	aspartate-rich region 1; other site
1234378001399	active site lid residues [active]
1234378001400	aspartate-rich region 2; other site
1234378001401	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1234378001402	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1234378001403	TPP-binding site; other site
1234378001404	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1234378001405	PYR/PP interface [polypeptide binding]; other site
1234378001406	dimer interface [polypeptide binding]; other site
1234378001407	TPP binding site [chemical binding]; other site
1234378001408	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1234378001409	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1234378001410	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1234378001411	Ligand Binding Site [chemical binding]; other site
1234378001412	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1234378001413	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1234378001414	substrate binding site [chemical binding]; other site
1234378001415	active site
1234378001416	catalytic residues [active]
1234378001417	heterodimer interface [polypeptide binding]; other site
1234378001418	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1234378001419	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1234378001420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378001421	catalytic residue [active]
1234378001422	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1234378001423	active site
1234378001424	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1234378001425	active site
1234378001426	ribulose/triose binding site [chemical binding]; other site
1234378001427	phosphate binding site [ion binding]; other site
1234378001428	substrate (anthranilate) binding pocket [chemical binding]; other site
1234378001429	product (indole) binding pocket [chemical binding]; other site
1234378001430	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1234378001431	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1234378001432	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1234378001433	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1234378001434	kynureninase; Region: kynureninase; TIGR01814
1234378001435	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1234378001436	catalytic residue [active]
1234378001437	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1234378001438	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1234378001439	TM-ABC transporter signature motif; other site
1234378001440	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1234378001441	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1234378001442	Walker A/P-loop; other site
1234378001443	ATP binding site [chemical binding]; other site
1234378001444	Q-loop/lid; other site
1234378001445	ABC transporter signature motif; other site
1234378001446	Walker B; other site
1234378001447	D-loop; other site
1234378001448	H-loop/switch region; other site
1234378001449	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1234378001450	zinc binding site [ion binding]; other site
1234378001451	putative ligand binding site [chemical binding]; other site
1234378001452	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1234378001453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1234378001454	NAD(P) binding site [chemical binding]; other site
1234378001455	active site
1234378001456	biotin synthase; Region: bioB; TIGR00433
1234378001457	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378001458	FeS/SAM binding site; other site
1234378001459	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1234378001460	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1234378001461	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1234378001462	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1234378001463	catalytic residue [active]
1234378001464	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1234378001465	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1234378001466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001467	S-adenosylmethionine binding site [chemical binding]; other site
1234378001468	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1234378001469	AAA domain; Region: AAA_26; pfam13500
1234378001470	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1234378001471	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1234378001472	inhibitor-cofactor binding pocket; inhibition site
1234378001473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378001474	catalytic residue [active]
1234378001475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1234378001476	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1234378001477	Na2 binding site [ion binding]; other site
1234378001478	putative substrate binding site 1 [chemical binding]; other site
1234378001479	Na binding site 1 [ion binding]; other site
1234378001480	putative substrate binding site 2 [chemical binding]; other site
1234378001481	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378001482	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1234378001483	FeS/SAM binding site; other site
1234378001484	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1234378001485	HIT family signature motif; other site
1234378001486	catalytic residue [active]
1234378001487	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1234378001488	IHF - DNA interface [nucleotide binding]; other site
1234378001489	IHF dimer interface [polypeptide binding]; other site
1234378001490	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1234378001491	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
1234378001492	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1234378001493	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1234378001494	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1234378001495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378001496	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378001497	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
1234378001498	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1234378001499	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378001500	homodimer interface [polypeptide binding]; other site
1234378001501	catalytic residue [active]
1234378001502	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1234378001503	catalytic core [active]
1234378001504	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1234378001505	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1234378001506	hydrogenase 1 large subunit; Provisional; Region: PRK10170
1234378001507	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1234378001508	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1234378001509	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1234378001510	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1234378001511	putative substrate-binding site; other site
1234378001512	nickel binding site [ion binding]; other site
1234378001513	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378001514	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1234378001515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378001516	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
1234378001517	putative active site [active]
1234378001518	dimerization interface [polypeptide binding]; other site
1234378001519	putative tRNAtyr binding site [nucleotide binding]; other site
1234378001520	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1234378001521	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1234378001522	substrate binding site; other site
1234378001523	dimer interface; other site
1234378001524	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1234378001525	homotrimer interaction site [polypeptide binding]; other site
1234378001526	zinc binding site [ion binding]; other site
1234378001527	CDP-binding sites; other site
1234378001528	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1234378001529	Putative zinc ribbon domain; Region: DUF164; pfam02591
1234378001530	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1234378001531	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1234378001532	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
1234378001533	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1234378001534	conserved cys residue [active]
1234378001535	CTP synthetase; Validated; Region: pyrG; PRK05380
1234378001536	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1234378001537	Catalytic site [active]
1234378001538	active site
1234378001539	UTP binding site [chemical binding]; other site
1234378001540	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1234378001541	active site
1234378001542	putative oxyanion hole; other site
1234378001543	catalytic triad [active]
1234378001544	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1234378001545	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1234378001546	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1234378001547	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1234378001548	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1234378001549	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1234378001550	OstA-like protein; Region: OstA; pfam03968
1234378001551	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1234378001552	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1234378001553	Walker A/P-loop; other site
1234378001554	ATP binding site [chemical binding]; other site
1234378001555	Q-loop/lid; other site
1234378001556	ABC transporter signature motif; other site
1234378001557	Walker B; other site
1234378001558	D-loop; other site
1234378001559	H-loop/switch region; other site
1234378001560	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1234378001561	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1234378001562	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1234378001563	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1234378001564	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1234378001565	30S subunit binding site; other site
1234378001566	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1234378001567	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1234378001568	substrate binding site [chemical binding]; other site
1234378001569	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1234378001570	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1234378001571	HIGH motif; other site
1234378001572	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1234378001573	active site
1234378001574	KMSKS motif; other site
1234378001575	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
1234378001576	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1234378001577	Phosphoglycerate kinase; Region: PGK; pfam00162
1234378001578	substrate binding site [chemical binding]; other site
1234378001579	hinge regions; other site
1234378001580	ADP binding site [chemical binding]; other site
1234378001581	catalytic site [active]
1234378001582	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1234378001583	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1234378001584	NAD binding site [chemical binding]; other site
1234378001585	homodimer interface [polypeptide binding]; other site
1234378001586	active site
1234378001587	substrate binding site [chemical binding]; other site
1234378001588	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1234378001589	active site clefts [active]
1234378001590	zinc binding site [ion binding]; other site
1234378001591	dimer interface [polypeptide binding]; other site
1234378001592	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1234378001593	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1234378001594	Walker A/P-loop; other site
1234378001595	ATP binding site [chemical binding]; other site
1234378001596	Q-loop/lid; other site
1234378001597	ABC transporter signature motif; other site
1234378001598	Walker B; other site
1234378001599	D-loop; other site
1234378001600	H-loop/switch region; other site
1234378001601	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1234378001602	putative carbohydrate binding site [chemical binding]; other site
1234378001603	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1234378001604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001605	S-adenosylmethionine binding site [chemical binding]; other site
1234378001606	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1234378001607	Peptidase family M23; Region: Peptidase_M23; pfam01551
1234378001608	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
1234378001609	putative active site [active]
1234378001610	putative metal binding site [ion binding]; other site
1234378001611	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1234378001612	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1234378001613	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1234378001614	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
1234378001615	ATP cone domain; Region: ATP-cone; pfam03477
1234378001616	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1234378001617	active site
1234378001618	dimer interface [polypeptide binding]; other site
1234378001619	catalytic residues [active]
1234378001620	effector binding site; other site
1234378001621	R2 peptide binding site; other site
1234378001622	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1234378001623	dimer interface [polypeptide binding]; other site
1234378001624	putative radical transfer pathway; other site
1234378001625	diiron center [ion binding]; other site
1234378001626	tyrosyl radical; other site
1234378001627	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
1234378001628	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1234378001629	active site
1234378001630	putative substrate binding pocket [chemical binding]; other site
1234378001631	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1234378001632	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
1234378001633	active site
1234378001634	catalytic triad [active]
1234378001635	oxyanion hole [active]
1234378001636	Predicted esterase [General function prediction only]; Region: COG0627
1234378001637	S-formylglutathione hydrolase; Region: PLN02442
1234378001638	Uncharacterized conserved protein [Function unknown]; Region: COG1433
1234378001639	flagellar motor protein MotA; Validated; Region: PRK09110
1234378001640	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1234378001641	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1234378001642	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1234378001643	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1234378001644	ligand binding site [chemical binding]; other site
1234378001645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378001646	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1234378001647	putative substrate translocation pore; other site
1234378001648	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1234378001649	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1234378001650	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1234378001651	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1234378001652	ligand binding site [chemical binding]; other site
1234378001653	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1234378001654	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1234378001655	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1234378001656	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1234378001657	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1234378001658	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
1234378001659	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1234378001660	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1234378001661	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1234378001662	dimer interface [polypeptide binding]; other site
1234378001663	ssDNA binding site [nucleotide binding]; other site
1234378001664	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1234378001665	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1234378001666	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1234378001667	active site
1234378001668	HIGH motif; other site
1234378001669	nucleotide binding site [chemical binding]; other site
1234378001670	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1234378001671	KMSKS motif; other site
1234378001672	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1234378001673	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
1234378001674	EF-hand domain pair; Region: EF_hand_5; pfam13499
1234378001675	Ca2+ binding site [ion binding]; other site
1234378001676	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378001677	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378001678	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1234378001679	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1234378001680	putative ligand binding site [chemical binding]; other site
1234378001681	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1234378001682	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1234378001683	TM-ABC transporter signature motif; other site
1234378001684	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1234378001685	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1234378001686	TM-ABC transporter signature motif; other site
1234378001687	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1234378001688	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1234378001689	Walker A/P-loop; other site
1234378001690	ATP binding site [chemical binding]; other site
1234378001691	Q-loop/lid; other site
1234378001692	ABC transporter signature motif; other site
1234378001693	Walker B; other site
1234378001694	D-loop; other site
1234378001695	H-loop/switch region; other site
1234378001696	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1234378001697	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1234378001698	Walker A/P-loop; other site
1234378001699	ATP binding site [chemical binding]; other site
1234378001700	Q-loop/lid; other site
1234378001701	ABC transporter signature motif; other site
1234378001702	Walker B; other site
1234378001703	D-loop; other site
1234378001704	H-loop/switch region; other site
1234378001705	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
1234378001706	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
1234378001707	YceG-like family; Region: YceG; pfam02618
1234378001708	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1234378001709	dimerization interface [polypeptide binding]; other site
1234378001710	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1234378001711	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1234378001712	thiS-thiF/thiG interaction site; other site
1234378001713	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1234378001714	ThiS interaction site; other site
1234378001715	putative active site [active]
1234378001716	tetramer interface [polypeptide binding]; other site
1234378001717	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1234378001718	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1234378001719	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
1234378001720	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
1234378001721	ATP binding site [chemical binding]; other site
1234378001722	substrate interface [chemical binding]; other site
1234378001723	multidrug efflux protein; Reviewed; Region: PRK01766
1234378001724	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1234378001725	cation binding site [ion binding]; other site
1234378001726	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1234378001727	Carbon starvation protein CstA; Region: CstA; pfam02554
1234378001728	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1234378001729	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1234378001730	EVE domain; Region: EVE; cl00728
1234378001731	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
1234378001732	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1234378001733	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378001734	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1234378001735	putative ADP-binding pocket [chemical binding]; other site
1234378001736	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1234378001737	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1234378001738	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1234378001739	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1234378001740	substrate binding pocket [chemical binding]; other site
1234378001741	chain length determination region; other site
1234378001742	substrate-Mg2+ binding site; other site
1234378001743	catalytic residues [active]
1234378001744	aspartate-rich region 1; other site
1234378001745	active site lid residues [active]
1234378001746	aspartate-rich region 2; other site
1234378001747	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
1234378001748	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
1234378001749	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1234378001750	dimerization interface [polypeptide binding]; other site
1234378001751	ATP binding site [chemical binding]; other site
1234378001752	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1234378001753	dimerization interface [polypeptide binding]; other site
1234378001754	ATP binding site [chemical binding]; other site
1234378001755	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1234378001756	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1234378001757	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1234378001758	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1234378001759	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1234378001760	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1234378001761	DNA binding residues [nucleotide binding]
1234378001762	DNA primase, catalytic core; Region: dnaG; TIGR01391
1234378001763	CHC2 zinc finger; Region: zf-CHC2; cl17510
1234378001764	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1234378001765	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1234378001766	active site
1234378001767	metal binding site [ion binding]; metal-binding site
1234378001768	interdomain interaction site; other site
1234378001769	Yqey-like protein; Region: YqeY; pfam09424
1234378001770	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1234378001771	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1234378001772	IHF dimer interface [polypeptide binding]; other site
1234378001773	IHF - DNA interface [nucleotide binding]; other site
1234378001774	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1234378001775	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1234378001776	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378001777	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1234378001778	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1234378001779	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1234378001780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378001781	active site
1234378001782	phosphorylation site [posttranslational modification]
1234378001783	intermolecular recognition site; other site
1234378001784	dimerization interface [polypeptide binding]; other site
1234378001785	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
1234378001786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1234378001787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1234378001788	DNA binding residues [nucleotide binding]
1234378001789	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1234378001790	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1234378001791	P-loop; other site
1234378001792	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
1234378001793	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
1234378001794	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1234378001795	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1234378001796	FHIPEP family; Region: FHIPEP; pfam00771
1234378001797	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1234378001798	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1234378001799	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1234378001800	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1234378001801	Sm and related proteins; Region: Sm_like; cl00259
1234378001802	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1234378001803	putative oligomer interface [polypeptide binding]; other site
1234378001804	putative RNA binding site [nucleotide binding]; other site
1234378001805	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1234378001806	NusA N-terminal domain; Region: NusA_N; pfam08529
1234378001807	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1234378001808	RNA binding site [nucleotide binding]; other site
1234378001809	homodimer interface [polypeptide binding]; other site
1234378001810	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1234378001811	G-X-X-G motif; other site
1234378001812	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1234378001813	G-X-X-G motif; other site
1234378001814	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1234378001815	translation initiation factor IF-2; Validated; Region: infB; PRK05306
1234378001816	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1234378001817	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1234378001818	G1 box; other site
1234378001819	putative GEF interaction site [polypeptide binding]; other site
1234378001820	GTP/Mg2+ binding site [chemical binding]; other site
1234378001821	Switch I region; other site
1234378001822	G2 box; other site
1234378001823	G3 box; other site
1234378001824	Switch II region; other site
1234378001825	G4 box; other site
1234378001826	G5 box; other site
1234378001827	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1234378001828	Translation-initiation factor 2; Region: IF-2; pfam11987
1234378001829	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1234378001830	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1234378001831	DHH family; Region: DHH; pfam01368
1234378001832	type III secretion system protein YscR; Provisional; Region: PRK12797
1234378001833	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1234378001834	Type III secretion protein YscO; Region: YscO; pfam07321
1234378001835	type III secretion system ATPase; Provisional; Region: PRK06936
1234378001836	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1234378001837	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1234378001838	Walker A motif/ATP binding site; other site
1234378001839	Walker B motif; other site
1234378001840	type III secretion system protein; Reviewed; Region: PRK06937
1234378001841	Flagellar assembly protein FliH; Region: FliH; pfam02108
1234378001842	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1234378001843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378001844	TPR motif; other site
1234378001845	binding surface
1234378001846	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029
1234378001847	type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503
1234378001848	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1234378001849	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1234378001850	FHIPEP family; Region: FHIPEP; pfam00771
1234378001851	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
1234378001852	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1234378001853	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
1234378001854	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1234378001855	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1234378001856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1234378001857	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1234378001858	ATP binding site [chemical binding]; other site
1234378001859	Mg2+ binding site [ion binding]; other site
1234378001860	G-X-G motif; other site
1234378001861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1234378001862	active site
1234378001863	phosphorylation site [posttranslational modification]
1234378001864	intermolecular recognition site; other site
1234378001865	dimerization interface [polypeptide binding]; other site
1234378001866	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1234378001867	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1234378001868	active site
1234378001869	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1234378001870	substrate binding site [chemical binding]; other site
1234378001871	catalytic residues [active]
1234378001872	dimer interface [polypeptide binding]; other site
1234378001873	histidinol dehydrogenase; Region: hisD; TIGR00069
1234378001874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378001875	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1234378001876	putative substrate translocation pore; other site
1234378001877	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1234378001878	HD domain; Region: HD_3; pfam13023
1234378001879	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1234378001880	23S rRNA interface [nucleotide binding]; other site
1234378001881	L3 interface [polypeptide binding]; other site
1234378001882	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1234378001883	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1234378001884	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1234378001885	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1234378001886	CHASE3 domain; Region: CHASE3; cl05000
1234378001887	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1234378001888	tetramer interfaces [polypeptide binding]; other site
1234378001889	binuclear metal-binding site [ion binding]; other site
1234378001890	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1234378001891	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1234378001892	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1234378001893	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1234378001894	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
1234378001895	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1234378001896	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1234378001897	Poxvirus P4A protein; Region: Pox_P4A; pfam03395
1234378001898	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1234378001899	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378001900	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378001901	putative active site [active]
1234378001902	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1234378001903	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1234378001904	ribonuclease III; Reviewed; Region: rnc; PRK00102
1234378001905	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1234378001906	dimerization interface [polypeptide binding]; other site
1234378001907	active site
1234378001908	metal binding site [ion binding]; metal-binding site
1234378001909	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1234378001910	dsRNA binding site [nucleotide binding]; other site
1234378001911	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1234378001912	RimM N-terminal domain; Region: RimM; pfam01782
1234378001913	PRC-barrel domain; Region: PRC; pfam05239
1234378001914	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1234378001915	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1234378001916	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1234378001917	signal recognition particle protein; Provisional; Region: PRK10867
1234378001918	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1234378001919	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1234378001920	P loop; other site
1234378001921	GTP binding site [chemical binding]; other site
1234378001922	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1234378001923	TRAM domain; Region: TRAM; pfam01938
1234378001924	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1234378001925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378001926	S-adenosylmethionine binding site [chemical binding]; other site
1234378001927	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1234378001928	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1234378001929	substrate binding site; other site
1234378001930	tetramer interface; other site
1234378001931	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1234378001932	purine monophosphate binding site [chemical binding]; other site
1234378001933	dimer interface [polypeptide binding]; other site
1234378001934	putative catalytic residues [active]
1234378001935	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1234378001936	active site
1234378001937	8-oxo-dGMP binding site [chemical binding]; other site
1234378001938	nudix motif; other site
1234378001939	metal binding site [ion binding]; metal-binding site
1234378001940	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1234378001941	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1234378001942	putative NAD(P) binding site [chemical binding]; other site
1234378001943	active site
1234378001944	putative substrate binding site [chemical binding]; other site
1234378001945	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1234378001946	Flavoprotein; Region: Flavoprotein; pfam02441
1234378001947	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1234378001948	TPR repeat; Region: TPR_11; pfam13414
1234378001949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378001950	binding surface
1234378001951	TPR motif; other site
1234378001952	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1234378001953	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1234378001954	active site
1234378001955	metal binding site [ion binding]; metal-binding site
1234378001956	DNA binding site [nucleotide binding]
1234378001957	AAA domain; Region: AAA_23; pfam13476
1234378001958	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1234378001959	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1234378001960	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1234378001961	GMP synthase; Reviewed; Region: guaA; PRK00074
1234378001962	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1234378001963	AMP/PPi binding site [chemical binding]; other site
1234378001964	candidate oxyanion hole; other site
1234378001965	catalytic triad [active]
1234378001966	potential glutamine specificity residues [chemical binding]; other site
1234378001967	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1234378001968	ATP Binding subdomain [chemical binding]; other site
1234378001969	Ligand Binding sites [chemical binding]; other site
1234378001970	Dimerization subdomain; other site
1234378001971	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1234378001972	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1234378001973	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1234378001974	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1234378001975	active site
1234378001976	maltose O-acetyltransferase; Provisional; Region: PRK10092
1234378001977	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1234378001978	active site
1234378001979	substrate binding site [chemical binding]; other site
1234378001980	trimer interface [polypeptide binding]; other site
1234378001981	CoA binding site [chemical binding]; other site
1234378001982	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1234378001983	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1234378001984	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
1234378001985	putative active site [active]
1234378001986	catalytic site [active]
1234378001987	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
1234378001988	putative active site [active]
1234378001989	catalytic site [active]
1234378001990	ribonuclease R; Region: RNase_R; TIGR02063
1234378001991	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1234378001992	RNB domain; Region: RNB; pfam00773
1234378001993	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1234378001994	RNA binding site [nucleotide binding]; other site
1234378001995	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
1234378001996	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
1234378001997	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1234378001998	dimer interface [polypeptide binding]; other site
1234378001999	catalytic triad [active]
1234378002000	peroxidatic and resolving cysteines [active]
1234378002001	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1234378002002	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1234378002003	metal binding site [ion binding]; metal-binding site
1234378002004	active site
1234378002005	I-site; other site
1234378002006	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1234378002007	nucleotidyl binding site; other site
1234378002008	metal binding site [ion binding]; metal-binding site
1234378002009	TPR repeat; Region: TPR_11; pfam13414
1234378002010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002011	TPR motif; other site
1234378002012	binding surface
1234378002013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002014	binding surface
1234378002015	TPR repeat; Region: TPR_11; pfam13414
1234378002016	TPR motif; other site
1234378002017	TPR repeat; Region: TPR_11; pfam13414
1234378002018	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1234378002019	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1234378002020	metal-binding site [ion binding]
1234378002021	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1234378002022	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1234378002023	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1234378002024	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1234378002025	Na binding site [ion binding]; other site
1234378002026	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1234378002027	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1234378002028	Cl- selectivity filter; other site
1234378002029	Cl- binding residues [ion binding]; other site
1234378002030	pore gating glutamate residue; other site
1234378002031	dimer interface [polypeptide binding]; other site
1234378002032	H+/Cl- coupling transport residue; other site
1234378002033	Protein of unknown function DUF45; Region: DUF45; pfam01863
1234378002034	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1234378002035	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1234378002036	DNA binding residues [nucleotide binding]
1234378002037	dimerization interface [polypeptide binding]; other site
1234378002038	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1234378002039	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1234378002040	metal binding site [ion binding]; metal-binding site
1234378002041	active site
1234378002042	I-site; other site
1234378002043	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1234378002044	diiron binding motif [ion binding]; other site
1234378002045	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
1234378002046	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1234378002047	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1234378002048	DNA-binding site [nucleotide binding]; DNA binding site
1234378002049	FCD domain; Region: FCD; pfam07729
1234378002050	Peptidase family M48; Region: Peptidase_M48; pfam01435
1234378002051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002052	binding surface
1234378002053	TPR motif; other site
1234378002054	TPR repeat; Region: TPR_11; pfam13414
1234378002055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002056	binding surface
1234378002057	TPR motif; other site
1234378002058	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1234378002059	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1234378002060	active site
1234378002061	HIGH motif; other site
1234378002062	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1234378002063	KMSKS motif; other site
1234378002064	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1234378002065	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1234378002066	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002067	binding surface
1234378002068	TPR motif; other site
1234378002069	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002070	binding surface
1234378002071	TPR motif; other site
1234378002072	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1234378002073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002074	binding surface
1234378002075	TPR motif; other site
1234378002076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002077	binding surface
1234378002078	TPR motif; other site
1234378002079	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002080	binding surface
1234378002081	TPR motif; other site
1234378002082	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
1234378002083	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1234378002084	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1234378002085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1234378002086	DNA binding residues [nucleotide binding]
1234378002087	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1234378002088	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1234378002089	catalytic residues [active]
1234378002090	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
1234378002091	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1234378002092	DNA repair protein RadA; Provisional; Region: PRK11823
1234378002093	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1234378002094	Walker A motif; other site
1234378002095	ATP binding site [chemical binding]; other site
1234378002096	Walker B motif; other site
1234378002097	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1234378002098	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1234378002099	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1234378002100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002101	Walker A motif; other site
1234378002102	ATP binding site [chemical binding]; other site
1234378002103	Walker B motif; other site
1234378002104	arginine finger; other site
1234378002105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002106	Walker A motif; other site
1234378002107	ATP binding site [chemical binding]; other site
1234378002108	Walker B motif; other site
1234378002109	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1234378002110	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1234378002111	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1234378002112	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
1234378002113	active site
1234378002114	Zn binding site [ion binding]; other site
1234378002115	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1234378002116	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1234378002117	NADP binding site [chemical binding]; other site
1234378002118	homopentamer interface [polypeptide binding]; other site
1234378002119	substrate binding site [chemical binding]; other site
1234378002120	active site
1234378002121	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
1234378002122	GTP1/OBG; Region: GTP1_OBG; pfam01018
1234378002123	Obg GTPase; Region: Obg; cd01898
1234378002124	G1 box; other site
1234378002125	GTP/Mg2+ binding site [chemical binding]; other site
1234378002126	Switch I region; other site
1234378002127	G2 box; other site
1234378002128	G3 box; other site
1234378002129	Switch II region; other site
1234378002130	G4 box; other site
1234378002131	G5 box; other site
1234378002132	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1234378002133	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1234378002134	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1234378002135	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1234378002136	oligomerisation interface [polypeptide binding]; other site
1234378002137	mobile loop; other site
1234378002138	roof hairpin; other site
1234378002139	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1234378002140	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1234378002141	ring oligomerisation interface [polypeptide binding]; other site
1234378002142	ATP/Mg binding site [chemical binding]; other site
1234378002143	stacking interactions; other site
1234378002144	hinge regions; other site
1234378002145	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1234378002146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378002147	S-adenosylmethionine binding site [chemical binding]; other site
1234378002148	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1234378002149	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1234378002150	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1234378002151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378002152	ATP binding site [chemical binding]; other site
1234378002153	Mg2+ binding site [ion binding]; other site
1234378002154	G-X-G motif; other site
1234378002155	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1234378002156	ATP binding site [chemical binding]; other site
1234378002157	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
1234378002158	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
1234378002159	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
1234378002160	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1234378002161	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1234378002162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1234378002163	nucleotide binding region [chemical binding]; other site
1234378002164	ATP-binding site [chemical binding]; other site
1234378002165	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1234378002166	dimerization interface [polypeptide binding]; other site
1234378002167	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1234378002168	ATP binding site [chemical binding]; other site
1234378002169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378002170	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1234378002171	putative substrate translocation pore; other site
1234378002172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378002173	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
1234378002174	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1234378002175	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1234378002176	acyl-activating enzyme (AAE) consensus motif; other site
1234378002177	active site
1234378002178	AMP binding site [chemical binding]; other site
1234378002179	CoA binding site [chemical binding]; other site
1234378002180	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1234378002181	IHF - DNA interface [nucleotide binding]; other site
1234378002182	IHF dimer interface [polypeptide binding]; other site
1234378002183	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1234378002184	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1234378002185	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1234378002186	DNA binding site [nucleotide binding]
1234378002187	catalytic residue [active]
1234378002188	H2TH interface [polypeptide binding]; other site
1234378002189	putative catalytic residues [active]
1234378002190	turnover-facilitating residue; other site
1234378002191	intercalation triad [nucleotide binding]; other site
1234378002192	8OG recognition residue [nucleotide binding]; other site
1234378002193	putative reading head residues; other site
1234378002194	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1234378002195	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1234378002196	Cupin domain; Region: Cupin_2; cl17218
1234378002197	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1234378002198	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1234378002199	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1234378002200	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1234378002201	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1234378002202	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1234378002203	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1234378002204	catalytic residue [active]
1234378002205	GTPase Era; Reviewed; Region: era; PRK00089
1234378002206	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1234378002207	G1 box; other site
1234378002208	GTP/Mg2+ binding site [chemical binding]; other site
1234378002209	Switch I region; other site
1234378002210	G2 box; other site
1234378002211	Switch II region; other site
1234378002212	G3 box; other site
1234378002213	G4 box; other site
1234378002214	G5 box; other site
1234378002215	KH domain; Region: KH_2; pfam07650
1234378002216	Peptidase family M48; Region: Peptidase_M48; cl12018
1234378002217	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1234378002218	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1234378002219	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1234378002220	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1234378002221	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1234378002222	phosphate binding site [ion binding]; other site
1234378002223	putative substrate binding pocket [chemical binding]; other site
1234378002224	dimer interface [polypeptide binding]; other site
1234378002225	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1234378002226	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1234378002227	active site
1234378002228	HIGH motif; other site
1234378002229	nucleotide binding site [chemical binding]; other site
1234378002230	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1234378002231	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1234378002232	active site
1234378002233	KMSKS motif; other site
1234378002234	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1234378002235	tRNA binding surface [nucleotide binding]; other site
1234378002236	anticodon binding site; other site
1234378002237	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1234378002238	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1234378002239	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
1234378002240	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1234378002241	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1234378002242	Peptidase M16C associated; Region: M16C_assoc; pfam08367
1234378002243	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1234378002244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1234378002245	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1234378002246	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1234378002247	active site residue [active]
1234378002248	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1234378002249	Peptidase family M48; Region: Peptidase_M48; pfam01435
1234378002250	DNA topoisomerase I; Validated; Region: PRK06599
1234378002251	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1234378002252	active site
1234378002253	interdomain interaction site; other site
1234378002254	putative metal-binding site [ion binding]; other site
1234378002255	nucleotide binding site [chemical binding]; other site
1234378002256	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1234378002257	domain I; other site
1234378002258	DNA binding groove [nucleotide binding]
1234378002259	phosphate binding site [ion binding]; other site
1234378002260	domain II; other site
1234378002261	domain III; other site
1234378002262	nucleotide binding site [chemical binding]; other site
1234378002263	catalytic site [active]
1234378002264	domain IV; other site
1234378002265	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1234378002266	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1234378002267	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1234378002268	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1234378002269	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1234378002270	argininosuccinate synthase; Provisional; Region: PRK13820
1234378002271	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1234378002272	ANP binding site [chemical binding]; other site
1234378002273	Substrate Binding Site II [chemical binding]; other site
1234378002274	Substrate Binding Site I [chemical binding]; other site
1234378002275	argininosuccinate lyase; Provisional; Region: PRK00855
1234378002276	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1234378002277	active sites [active]
1234378002278	tetramer interface [polypeptide binding]; other site
1234378002279	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1234378002280	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1234378002281	Shikimate kinase; Region: SKI; pfam01202
1234378002282	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1234378002283	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1234378002284	Ferritin-like domain; Region: Ferritin; pfam00210
1234378002285	heme binding site [chemical binding]; other site
1234378002286	ferroxidase pore; other site
1234378002287	ferroxidase diiron center [ion binding]; other site
1234378002288	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1234378002289	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1234378002290	glutaminase active site [active]
1234378002291	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1234378002292	dimer interface [polypeptide binding]; other site
1234378002293	active site
1234378002294	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1234378002295	dimer interface [polypeptide binding]; other site
1234378002296	active site
1234378002297	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
1234378002298	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1234378002299	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1234378002300	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1234378002301	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1234378002302	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1234378002303	Autotransporter beta-domain; Region: Autotransporter; cl17461
1234378002304	Tir chaperone protein (CesT) family; Region: CesT; cl08444
1234378002305	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378002306	Adenosylhomocysteinase; Provisional; Region: PTZ00075
1234378002307	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1234378002308	homotetramer interface [polypeptide binding]; other site
1234378002309	ligand binding site [chemical binding]; other site
1234378002310	catalytic site [active]
1234378002311	NAD binding site [chemical binding]; other site
1234378002312	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1234378002313	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
1234378002314	putative ligand binding site [chemical binding]; other site
1234378002315	putative NAD binding site [chemical binding]; other site
1234378002316	catalytic site [active]
1234378002317	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1234378002318	Part of AAA domain; Region: AAA_19; pfam13245
1234378002319	Family description; Region: UvrD_C_2; pfam13538
1234378002320	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1234378002321	thiamine monophosphate kinase; Provisional; Region: PRK05731
1234378002322	ATP binding site [chemical binding]; other site
1234378002323	dimerization interface [polypeptide binding]; other site
1234378002324	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1234378002325	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1234378002326	active site
1234378002327	substrate binding site [chemical binding]; other site
1234378002328	metal binding site [ion binding]; metal-binding site
1234378002329	HflK protein; Region: hflK; TIGR01933
1234378002330	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1234378002331	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1234378002332	HflC protein; Region: hflC; TIGR01932
1234378002333	Predicted transcriptional regulator [Transcription]; Region: COG2932
1234378002334	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
1234378002335	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1234378002336	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1234378002337	active site
1234378002338	dimerization interface [polypeptide binding]; other site
1234378002339	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460
1234378002340	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378002341	FeS/SAM binding site; other site
1234378002342	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1234378002343	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1234378002344	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1234378002345	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1234378002346	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1234378002347	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378002348	Zn2+ binding site [ion binding]; other site
1234378002349	Mg2+ binding site [ion binding]; other site
1234378002350	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1234378002351	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1234378002352	Coenzyme A binding pocket [chemical binding]; other site
1234378002353	chaperone protein DnaJ; Provisional; Region: PRK14301
1234378002354	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1234378002355	HSP70 interaction site [polypeptide binding]; other site
1234378002356	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1234378002357	substrate binding site [polypeptide binding]; other site
1234378002358	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1234378002359	Zn binding sites [ion binding]; other site
1234378002360	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1234378002361	dimer interface [polypeptide binding]; other site
1234378002362	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1234378002363	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1234378002364	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1234378002365	interface (dimer of trimers) [polypeptide binding]; other site
1234378002366	Substrate-binding/catalytic site; other site
1234378002367	Zn-binding sites [ion binding]; other site
1234378002368	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1234378002369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378002370	active site
1234378002371	phosphorylation site [posttranslational modification]
1234378002372	intermolecular recognition site; other site
1234378002373	dimerization interface [polypeptide binding]; other site
1234378002374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002375	Walker A motif; other site
1234378002376	ATP binding site [chemical binding]; other site
1234378002377	Walker B motif; other site
1234378002378	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1234378002379	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1234378002380	Surface antigen; Region: Bac_surface_Ag; pfam01103
1234378002381	Family of unknown function (DUF490); Region: DUF490; pfam04357
1234378002382	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1234378002383	dimer interface [polypeptide binding]; other site
1234378002384	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1234378002385	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1234378002386	ligand binding site [chemical binding]; other site
1234378002387	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
1234378002388	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1234378002389	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1234378002390	TonB C terminal; Region: TonB_2; pfam13103
1234378002391	TolA protein; Region: tolA_full; TIGR02794
1234378002392	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1234378002393	TolR protein; Region: tolR; TIGR02801
1234378002394	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1234378002395	Rubrerythrin [Energy production and conversion]; Region: COG1592
1234378002396	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1234378002397	binuclear metal center [ion binding]; other site
1234378002398	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1234378002399	iron binding site [ion binding]; other site
1234378002400	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1234378002401	Rubredoxin; Region: Rubredoxin; pfam00301
1234378002402	iron binding site [ion binding]; other site
1234378002403	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378002404	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378002405	putative active site [active]
1234378002406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002407	binding surface
1234378002408	TPR motif; other site
1234378002409	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1234378002410	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1234378002411	GIY-YIG motif/motif A; other site
1234378002412	active site
1234378002413	catalytic site [active]
1234378002414	putative DNA binding site [nucleotide binding]; other site
1234378002415	metal binding site [ion binding]; metal-binding site
1234378002416	UvrB/uvrC motif; Region: UVR; pfam02151
1234378002417	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1234378002418	Maf-like protein; Region: Maf; pfam02545
1234378002419	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1234378002420	active site
1234378002421	dimer interface [polypeptide binding]; other site
1234378002422	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1234378002423	DHH family; Region: DHH; pfam01368
1234378002424	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1234378002425	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1234378002426	putative dimer interface [polypeptide binding]; other site
1234378002427	putative anticodon binding site; other site
1234378002428	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1234378002429	homodimer interface [polypeptide binding]; other site
1234378002430	motif 1; other site
1234378002431	motif 2; other site
1234378002432	active site
1234378002433	motif 3; other site
1234378002434	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1234378002435	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1234378002436	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
1234378002437	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1234378002438	Part of AAA domain; Region: AAA_19; pfam13245
1234378002439	Family description; Region: UvrD_C_2; pfam13538
1234378002440	Acylphosphatase; Region: Acylphosphatase; pfam00708
1234378002441	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1234378002442	HypF finger; Region: zf-HYPF; pfam07503
1234378002443	HypF finger; Region: zf-HYPF; pfam07503
1234378002444	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1234378002445	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1234378002446	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1234378002447	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1234378002448	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1234378002449	active site
1234378002450	Riboflavin kinase; Region: Flavokinase; pfam01687
1234378002451	flagellin; Provisional; Region: PRK12802
1234378002452	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1234378002453	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1234378002454	Colicin V production protein; Region: Colicin_V; pfam02674
1234378002455	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1234378002456	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1234378002457	heterodimer interface [polypeptide binding]; other site
1234378002458	active site
1234378002459	FMN binding site [chemical binding]; other site
1234378002460	homodimer interface [polypeptide binding]; other site
1234378002461	substrate binding site [chemical binding]; other site
1234378002462	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1234378002463	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1234378002464	FAD binding pocket [chemical binding]; other site
1234378002465	FAD binding motif [chemical binding]; other site
1234378002466	phosphate binding motif [ion binding]; other site
1234378002467	beta-alpha-beta structure motif; other site
1234378002468	NAD binding pocket [chemical binding]; other site
1234378002469	Iron coordination center [ion binding]; other site
1234378002470	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1234378002471	heterotetramer interface [polypeptide binding]; other site
1234378002472	active site pocket [active]
1234378002473	cleavage site
1234378002474	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1234378002475	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1234378002476	RNA binding surface [nucleotide binding]; other site
1234378002477	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1234378002478	active site
1234378002479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1234378002480	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1234378002481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378002482	putative PBP binding loops; other site
1234378002483	dimer interface [polypeptide binding]; other site
1234378002484	ABC-ATPase subunit interface; other site
1234378002485	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1234378002486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378002487	Walker A/P-loop; other site
1234378002488	ATP binding site [chemical binding]; other site
1234378002489	Q-loop/lid; other site
1234378002490	ABC transporter signature motif; other site
1234378002491	Walker B; other site
1234378002492	D-loop; other site
1234378002493	H-loop/switch region; other site
1234378002494	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1234378002495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378002496	dimer interface [polypeptide binding]; other site
1234378002497	conserved gate region; other site
1234378002498	putative PBP binding loops; other site
1234378002499	ABC-ATPase subunit interface; other site
1234378002500	GTP-binding protein LepA; Provisional; Region: PRK05433
1234378002501	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1234378002502	G1 box; other site
1234378002503	putative GEF interaction site [polypeptide binding]; other site
1234378002504	GTP/Mg2+ binding site [chemical binding]; other site
1234378002505	Switch I region; other site
1234378002506	G2 box; other site
1234378002507	G3 box; other site
1234378002508	Switch II region; other site
1234378002509	G4 box; other site
1234378002510	G5 box; other site
1234378002511	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1234378002512	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1234378002513	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1234378002514	MltA specific insert domain; Region: MltA; smart00925
1234378002515	3D domain; Region: 3D; pfam06725
1234378002516	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1234378002517	active site
1234378002518	histidinol-phosphatase; Provisional; Region: PRK07328
1234378002519	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1234378002520	active site
1234378002521	dimer interface [polypeptide binding]; other site
1234378002522	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1234378002523	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1234378002524	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1234378002525	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1234378002526	LytB protein; Region: LYTB; cl00507
1234378002527	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
1234378002528	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1234378002529	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1234378002530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378002531	active site
1234378002532	phosphorylation site [posttranslational modification]
1234378002533	intermolecular recognition site; other site
1234378002534	dimerization interface [polypeptide binding]; other site
1234378002535	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1234378002536	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1234378002537	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1234378002538	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1234378002539	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1234378002540	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1234378002541	active site
1234378002542	HslU subunit interaction site [polypeptide binding]; other site
1234378002543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1234378002544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1234378002545	substrate binding pocket [chemical binding]; other site
1234378002546	membrane-bound complex binding site; other site
1234378002547	hinge residues; other site
1234378002548	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1234378002549	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615
1234378002550	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1234378002551	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1234378002552	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1234378002553	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1234378002554	active site
1234378002555	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1234378002556	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1234378002557	5S rRNA interface [nucleotide binding]; other site
1234378002558	CTC domain interface [polypeptide binding]; other site
1234378002559	L16 interface [polypeptide binding]; other site
1234378002560	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1234378002561	putative active site [active]
1234378002562	catalytic residue [active]
1234378002563	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1234378002564	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1234378002565	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
1234378002566	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1234378002567	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1234378002568	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1234378002569	SAF-like; Region: SAF_2; pfam13144
1234378002570	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
1234378002571	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
1234378002572	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1234378002573	Flagellar L-ring protein; Region: FlgH; pfam02107
1234378002574	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1234378002575	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1234378002576	Rod binding protein; Region: Rod-binding; cl01626
1234378002577	FlgN protein; Region: FlgN; pfam05130
1234378002578	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1234378002579	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
1234378002580	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1234378002581	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1234378002582	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1234378002583	Global regulator protein family; Region: CsrA; pfam02599
1234378002584	FliW protein; Region: FliW; cl00740
1234378002585	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1234378002586	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1234378002587	putative substrate binding site [chemical binding]; other site
1234378002588	putative ATP binding site [chemical binding]; other site
1234378002589	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1234378002590	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1234378002591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002592	Walker A motif; other site
1234378002593	ATP binding site [chemical binding]; other site
1234378002594	Walker B motif; other site
1234378002595	arginine finger; other site
1234378002596	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1234378002597	putative transporter; Provisional; Region: PRK11660
1234378002598	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1234378002599	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1234378002600	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1234378002601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378002602	dimer interface [polypeptide binding]; other site
1234378002603	conserved gate region; other site
1234378002604	putative PBP binding loops; other site
1234378002605	ABC-ATPase subunit interface; other site
1234378002606	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1234378002607	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1234378002608	substrate binding pocket [chemical binding]; other site
1234378002609	membrane-bound complex binding site; other site
1234378002610	hinge residues; other site
1234378002611	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1234378002612	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1234378002613	RNA binding site [nucleotide binding]; other site
1234378002614	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1234378002615	RNA binding site [nucleotide binding]; other site
1234378002616	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1234378002617	RNA binding site [nucleotide binding]; other site
1234378002618	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1234378002619	RNA binding site [nucleotide binding]; other site
1234378002620	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1234378002621	RNA binding site [nucleotide binding]; other site
1234378002622	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1234378002623	RNA binding site [nucleotide binding]; other site
1234378002624	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1234378002625	RNA/DNA hybrid binding site [nucleotide binding]; other site
1234378002626	active site
1234378002627	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1234378002628	UbiA prenyltransferase family; Region: UbiA; pfam01040
1234378002629	CAAX protease self-immunity; Region: Abi; pfam02517
1234378002630	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1234378002631	UbiA prenyltransferase family; Region: UbiA; pfam01040
1234378002632	thymidylate kinase; Validated; Region: tmk; PRK00698
1234378002633	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1234378002634	TMP-binding site; other site
1234378002635	ATP-binding site [chemical binding]; other site
1234378002636	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1234378002637	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1234378002638	generic binding surface I; other site
1234378002639	generic binding surface II; other site
1234378002640	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378002641	Zn2+ binding site [ion binding]; other site
1234378002642	Mg2+ binding site [ion binding]; other site
1234378002643	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1234378002644	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1234378002645	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1234378002646	intersubunit interface [polypeptide binding]; other site
1234378002647	active site
1234378002648	zinc binding site [ion binding]; other site
1234378002649	Na+ binding site [ion binding]; other site
1234378002650	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1234378002651	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1234378002652	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1234378002653	Protein of unknown function DUF116; Region: DUF116; pfam01976
1234378002654	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1234378002655	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1234378002656	putative active site [active]
1234378002657	substrate binding site [chemical binding]; other site
1234378002658	putative cosubstrate binding site; other site
1234378002659	catalytic site [active]
1234378002660	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1234378002661	substrate binding site [chemical binding]; other site
1234378002662	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1234378002663	active site
1234378002664	catalytic residues [active]
1234378002665	metal binding site [ion binding]; metal-binding site
1234378002666	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1234378002667	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1234378002668	FMN binding site [chemical binding]; other site
1234378002669	active site
1234378002670	catalytic residues [active]
1234378002671	substrate binding site [chemical binding]; other site
1234378002672	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1234378002673	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1234378002674	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1234378002675	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1234378002676	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1234378002677	homodimer interface [polypeptide binding]; other site
1234378002678	oligonucleotide binding site [chemical binding]; other site
1234378002679	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
1234378002680	Ligand Binding Site [chemical binding]; other site
1234378002681	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1234378002682	putative cation:proton antiport protein; Provisional; Region: PRK10669
1234378002683	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1234378002684	TrkA-N domain; Region: TrkA_N; pfam02254
1234378002685	TrkA-C domain; Region: TrkA_C; pfam02080
1234378002686	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1234378002687	TrkA-N domain; Region: TrkA_N; pfam02254
1234378002688	TrkA-C domain; Region: TrkA_C; pfam02080
1234378002689	TrkA-N domain; Region: TrkA_N; pfam02254
1234378002690	TrkA-C domain; Region: TrkA_C; pfam02080
1234378002691	Cation transport protein; Region: TrkH; cl17365
1234378002692	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1234378002693	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1234378002694	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1234378002695	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1234378002696	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1234378002697	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1234378002698	minor groove reading motif; other site
1234378002699	helix-hairpin-helix signature motif; other site
1234378002700	substrate binding pocket [chemical binding]; other site
1234378002701	active site
1234378002702	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1234378002703	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
1234378002704	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1234378002705	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1234378002706	substrate binding site [chemical binding]; other site
1234378002707	ATP binding site [chemical binding]; other site
1234378002708	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288
1234378002709	putative active site [active]
1234378002710	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1234378002711	dimer interface [polypeptide binding]; other site
1234378002712	substrate binding site [chemical binding]; other site
1234378002713	ATP binding site [chemical binding]; other site
1234378002714	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1234378002715	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1234378002716	DNA gyrase subunit A; Validated; Region: PRK05560
1234378002717	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1234378002718	CAP-like domain; other site
1234378002719	active site
1234378002720	primary dimer interface [polypeptide binding]; other site
1234378002721	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1234378002722	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1234378002723	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1234378002724	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1234378002725	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1234378002726	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1234378002727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378002728	ATP binding site [chemical binding]; other site
1234378002729	Mg2+ binding site [ion binding]; other site
1234378002730	G-X-G motif; other site
1234378002731	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1234378002732	anchoring element; other site
1234378002733	dimer interface [polypeptide binding]; other site
1234378002734	ATP binding site [chemical binding]; other site
1234378002735	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1234378002736	active site
1234378002737	putative metal-binding site [ion binding]; other site
1234378002738	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1234378002739	DNA polymerase III subunit beta; Provisional; Region: PRK14947
1234378002740	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1234378002741	putative DNA binding surface [nucleotide binding]; other site
1234378002742	dimer interface [polypeptide binding]; other site
1234378002743	beta-clamp/clamp loader binding surface; other site
1234378002744	beta-clamp/translesion DNA polymerase binding surface; other site
1234378002745	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1234378002746	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002747	Walker A motif; other site
1234378002748	ATP binding site [chemical binding]; other site
1234378002749	Walker B motif; other site
1234378002750	arginine finger; other site
1234378002751	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1234378002752	DnaA box-binding interface [nucleotide binding]; other site
1234378002753	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1234378002754	Peptidase family M23; Region: Peptidase_M23; pfam01551
1234378002755	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
1234378002756	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1234378002757	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1234378002758	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1234378002759	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
1234378002760	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1234378002761	dimer interface [polypeptide binding]; other site
1234378002762	PYR/PP interface [polypeptide binding]; other site
1234378002763	TPP binding site [chemical binding]; other site
1234378002764	substrate binding site [chemical binding]; other site
1234378002765	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
1234378002766	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1234378002767	TPP-binding site [chemical binding]; other site
1234378002768	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
1234378002769	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
1234378002770	trigger factor; Region: tig; TIGR00115
1234378002771	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1234378002772	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1234378002773	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1234378002774	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1234378002775	oligomer interface [polypeptide binding]; other site
1234378002776	active site residues [active]
1234378002777	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1234378002778	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1234378002779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002780	Walker A motif; other site
1234378002781	ATP binding site [chemical binding]; other site
1234378002782	Walker B motif; other site
1234378002783	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1234378002784	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1234378002785	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1234378002786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378002787	Walker A motif; other site
1234378002788	ATP binding site [chemical binding]; other site
1234378002789	Walker B motif; other site
1234378002790	arginine finger; other site
1234378002791	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1234378002792	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1234378002793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378002794	FeS/SAM binding site; other site
1234378002795	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1234378002796	Ligand Binding Site [chemical binding]; other site
1234378002797	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356
1234378002798	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1234378002799	Substrate binding site; other site
1234378002800	Mg++ binding site; other site
1234378002801	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1234378002802	active site
1234378002803	substrate binding site [chemical binding]; other site
1234378002804	CoA binding site [chemical binding]; other site
1234378002805	rod shape-determining protein MreC; Provisional; Region: PRK13922
1234378002806	ribonuclease Y; Region: RNase_Y; TIGR03319
1234378002807	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378002808	Zn2+ binding site [ion binding]; other site
1234378002809	Mg2+ binding site [ion binding]; other site
1234378002810	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1234378002811	active site
1234378002812	hypothetical protein; Provisional; Region: PRK10519
1234378002813	Nucleoside recognition; Region: Gate; pfam07670
1234378002814	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1234378002815	acyl-activating enzyme (AAE) consensus motif; other site
1234378002816	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1234378002817	AMP binding site [chemical binding]; other site
1234378002818	active site
1234378002819	CoA binding site [chemical binding]; other site
1234378002820	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1234378002821	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1234378002822	substrate binding site [chemical binding]; other site
1234378002823	oxyanion hole (OAH) forming residues; other site
1234378002824	trimer interface [polypeptide binding]; other site
1234378002825	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1234378002826	CoenzymeA binding site [chemical binding]; other site
1234378002827	subunit interaction site [polypeptide binding]; other site
1234378002828	PHB binding site; other site
1234378002829	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1234378002830	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1234378002831	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1234378002832	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1234378002833	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1234378002834	RNA binding surface [nucleotide binding]; other site
1234378002835	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1234378002836	active site
1234378002837	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1234378002838	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1234378002839	CoA-binding site [chemical binding]; other site
1234378002840	ATP-binding [chemical binding]; other site
1234378002841	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1234378002842	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378002843	P-loop; other site
1234378002844	Magnesium ion binding site [ion binding]; other site
1234378002845	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378002846	Magnesium ion binding site [ion binding]; other site
1234378002847	ParB-like nuclease domain; Region: ParB; smart00470
1234378002848	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1234378002849	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1234378002850	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1234378002851	putative ribose interaction site [chemical binding]; other site
1234378002852	putative ADP binding site [chemical binding]; other site
1234378002853	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
1234378002854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378002855	FeS/SAM binding site; other site
1234378002856	HemN C-terminal domain; Region: HemN_C; pfam06969
1234378002857	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1234378002858	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1234378002859	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1234378002860	dihydroorotase; Validated; Region: pyrC; PRK09357
1234378002861	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1234378002862	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1234378002863	active site
1234378002864	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1234378002865	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1234378002866	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337
1234378002867	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1234378002868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378002869	FeS/SAM binding site; other site
1234378002870	hypothetical protein; Provisional; Region: PRK06361
1234378002871	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1234378002872	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1234378002873	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1234378002874	active site
1234378002875	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378002876	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1234378002877	putative ADP-binding pocket [chemical binding]; other site
1234378002878	O-Antigen ligase; Region: Wzy_C; pfam04932
1234378002879	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1234378002880	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1234378002881	putative ligand binding site [chemical binding]; other site
1234378002882	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1234378002883	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1234378002884	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1234378002885	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1234378002886	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1234378002887	Walker A/P-loop; other site
1234378002888	ATP binding site [chemical binding]; other site
1234378002889	Q-loop/lid; other site
1234378002890	ABC transporter signature motif; other site
1234378002891	Walker B; other site
1234378002892	D-loop; other site
1234378002893	H-loop/switch region; other site
1234378002894	RNA polymerase III subunit Rpc25; Region: RNA_pol_Rbc25; pfam08292
1234378002895	TOBE domain; Region: TOBE_2; pfam08402
1234378002896	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1234378002897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378002898	dimer interface [polypeptide binding]; other site
1234378002899	conserved gate region; other site
1234378002900	putative PBP binding loops; other site
1234378002901	ABC-ATPase subunit interface; other site
1234378002902	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1234378002903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378002904	dimer interface [polypeptide binding]; other site
1234378002905	conserved gate region; other site
1234378002906	putative PBP binding loops; other site
1234378002907	ABC-ATPase subunit interface; other site
1234378002908	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1234378002909	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1234378002910	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
1234378002911	Protein of unknown function (DUF935); Region: DUF935; pfam06074
1234378002912	Mor transcription activator family; Region: Mor; cl02360
1234378002913	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
1234378002914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1234378002915	non-specific DNA binding site [nucleotide binding]; other site
1234378002916	salt bridge; other site
1234378002917	sequence-specific DNA binding site [nucleotide binding]; other site
1234378002918	Predicted transcriptional regulator [Transcription]; Region: COG2932
1234378002919	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1234378002920	Catalytic site [active]
1234378002921	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1234378002922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378002923	TPR motif; other site
1234378002924	binding surface
1234378002925	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1234378002926	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1234378002927	hinge; other site
1234378002928	active site
1234378002929	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1234378002930	putative catalytic site [active]
1234378002931	putative metal binding site [ion binding]; other site
1234378002932	putative phosphate binding site [ion binding]; other site
1234378002933	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1234378002934	hydroperoxidase II; Provisional; Region: katE; PRK11249
1234378002935	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1234378002936	tetramer interface [polypeptide binding]; other site
1234378002937	heme binding pocket [chemical binding]; other site
1234378002938	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1234378002939	domain interactions; other site
1234378002940	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1234378002941	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1234378002942	dimerization interface [polypeptide binding]; other site
1234378002943	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1234378002944	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1234378002945	dimer interface [polypeptide binding]; other site
1234378002946	putative CheW interface [polypeptide binding]; other site
1234378002947	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1234378002948	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1234378002949	Family description; Region: VCBS; pfam13517
1234378002950	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378002951	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1234378002952	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1234378002953	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1234378002954	Glucose inhibited division protein A; Region: GIDA; pfam01134
1234378002955	HD domain; Region: HD_3; pfam13023
1234378002956	HI0933-like protein; Region: HI0933_like; pfam03486
1234378002957	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1234378002958	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1234378002959	FMN binding site [chemical binding]; other site
1234378002960	dimer interface [polypeptide binding]; other site
1234378002961	OsmC-like protein; Region: OsmC; pfam02566
1234378002962	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
1234378002963	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1234378002964	Walker A motif/ATP binding site; other site
1234378002965	Walker B motif; other site
1234378002966	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1234378002967	Flagellar assembly protein FliH; Region: FliH; pfam02108
1234378002968	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1234378002969	FliG C-terminal domain; Region: FliG_C; pfam01706
1234378002970	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1234378002971	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1234378002972	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1234378002973	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
1234378002974	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1234378002975	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1234378002976	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621
1234378002977	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1234378002978	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1234378002979	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1234378002980	Walker A/P-loop; other site
1234378002981	ATP binding site [chemical binding]; other site
1234378002982	Q-loop/lid; other site
1234378002983	ABC transporter signature motif; other site
1234378002984	Walker B; other site
1234378002985	D-loop; other site
1234378002986	H-loop/switch region; other site
1234378002987	Cobalt transport protein; Region: CbiQ; cl00463
1234378002988	cobalt transport protein CbiM; Validated; Region: PRK06265
1234378002989	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1234378002990	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1234378002991	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1234378002992	MviN-like protein; Region: MVIN; pfam03023
1234378002993	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1234378002994	Competence protein; Region: Competence; pfam03772
1234378002995	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1234378002996	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1234378002997	glutamate racemase; Provisional; Region: PRK00865
1234378002998	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1234378002999	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1234378003000	RNA binding surface [nucleotide binding]; other site
1234378003001	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1234378003002	active site
1234378003003	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1234378003004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1234378003005	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1234378003006	Walker A/P-loop; other site
1234378003007	ATP binding site [chemical binding]; other site
1234378003008	Q-loop/lid; other site
1234378003009	ABC transporter signature motif; other site
1234378003010	Walker B; other site
1234378003011	D-loop; other site
1234378003012	H-loop/switch region; other site
1234378003013	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1234378003014	putative acyl-acceptor binding pocket; other site
1234378003015	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1234378003016	putative acyl-acceptor binding pocket; other site
1234378003017	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1234378003018	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1234378003019	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1234378003020	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
1234378003021	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1234378003022	Potassium binding sites [ion binding]; other site
1234378003023	Cesium cation binding sites [ion binding]; other site
1234378003024	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14168
1234378003025	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1234378003026	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1234378003027	homodimer interface [polypeptide binding]; other site
1234378003028	NADP binding site [chemical binding]; other site
1234378003029	substrate binding site [chemical binding]; other site
1234378003030	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1234378003031	NusB family; Region: NusB; pfam01029
1234378003032	putative RNA binding site [nucleotide binding]; other site
1234378003033	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1234378003034	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1234378003035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003036	active site
1234378003037	phosphorylation site [posttranslational modification]
1234378003038	intermolecular recognition site; other site
1234378003039	dimerization interface [polypeptide binding]; other site
1234378003040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378003041	Walker A motif; other site
1234378003042	ATP binding site [chemical binding]; other site
1234378003043	Walker B motif; other site
1234378003044	arginine finger; other site
1234378003045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1234378003046	dimer interface [polypeptide binding]; other site
1234378003047	phosphorylation site [posttranslational modification]
1234378003048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378003049	ATP binding site [chemical binding]; other site
1234378003050	Mg2+ binding site [ion binding]; other site
1234378003051	G-X-G motif; other site
1234378003052	glucose-6-phosphate isomerase; Provisional; Region: PRK03868
1234378003053	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1234378003054	active site
1234378003055	dimer interface [polypeptide binding]; other site
1234378003056	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1234378003057	dimer interface [polypeptide binding]; other site
1234378003058	active site
1234378003059	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1234378003060	Predicted permeases [General function prediction only]; Region: COG0795
1234378003061	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1234378003062	Predicted permeases [General function prediction only]; Region: COG0795
1234378003063	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1234378003064	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1234378003065	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1234378003066	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
1234378003067	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1234378003068	G1 box; other site
1234378003069	putative GEF interaction site [polypeptide binding]; other site
1234378003070	GTP/Mg2+ binding site [chemical binding]; other site
1234378003071	Switch I region; other site
1234378003072	G2 box; other site
1234378003073	G3 box; other site
1234378003074	Switch II region; other site
1234378003075	G4 box; other site
1234378003076	G5 box; other site
1234378003077	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1234378003078	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1234378003079	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1234378003080	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1234378003081	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1234378003082	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1234378003083	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1234378003084	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1234378003085	Ligand Binding Site [chemical binding]; other site
1234378003086	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1234378003087	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378003088	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1234378003089	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1234378003090	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1234378003091	putative active site [active]
1234378003092	catalytic triad [active]
1234378003093	putative dimer interface [polypeptide binding]; other site
1234378003094	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1234378003095	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1234378003096	RF-1 domain; Region: RF-1; pfam00472
1234378003097	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1234378003098	IHF - DNA interface [nucleotide binding]; other site
1234378003099	IHF dimer interface [polypeptide binding]; other site
1234378003100	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1234378003101	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1234378003102	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1234378003103	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1234378003104	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1234378003105	dimer interface [polypeptide binding]; other site
1234378003106	active site
1234378003107	catalytic residue [active]
1234378003108	MFS transport protein AraJ; Provisional; Region: PRK10091
1234378003109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378003110	putative substrate translocation pore; other site
1234378003111	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1234378003112	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1234378003113	active site
1234378003114	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
1234378003115	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1234378003116	DsrC like protein; Region: DsrC; pfam04358
1234378003117	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1234378003118	metal ion-dependent adhesion site (MIDAS); other site
1234378003119	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1234378003120	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1234378003121	ligand binding site [chemical binding]; other site
1234378003122	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1234378003123	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1234378003124	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1234378003125	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1234378003126	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1234378003127	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1234378003128	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1234378003129	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1234378003130	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1234378003131	DNA binding site [nucleotide binding]
1234378003132	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1234378003133	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1234378003134	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1234378003135	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1234378003136	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1234378003137	RPB11 interaction site [polypeptide binding]; other site
1234378003138	RPB12 interaction site [polypeptide binding]; other site
1234378003139	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1234378003140	RPB3 interaction site [polypeptide binding]; other site
1234378003141	RPB1 interaction site [polypeptide binding]; other site
1234378003142	RPB11 interaction site [polypeptide binding]; other site
1234378003143	RPB10 interaction site [polypeptide binding]; other site
1234378003144	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1234378003145	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1234378003146	inhibitor-cofactor binding pocket; inhibition site
1234378003147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378003148	catalytic residue [active]
1234378003149	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1234378003150	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1234378003151	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1234378003152	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1234378003153	rRNA binding site [nucleotide binding]; other site
1234378003154	predicted 30S ribosome binding site; other site
1234378003155	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1234378003156	cytidylate kinase; Provisional; Region: cmk; PRK00023
1234378003157	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1234378003158	CMP-binding site; other site
1234378003159	The sites determining sugar specificity; other site
1234378003160	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1234378003161	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1234378003162	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1234378003163	nucleotide binding site [chemical binding]; other site
1234378003164	NEF interaction site [polypeptide binding]; other site
1234378003165	SBD interface [polypeptide binding]; other site
1234378003166	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1234378003167	Aspartase; Region: Aspartase; cd01357
1234378003168	active sites [active]
1234378003169	tetramer interface [polypeptide binding]; other site
1234378003170	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1234378003171	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1234378003172	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1234378003173	homodimer interface [polypeptide binding]; other site
1234378003174	substrate-cofactor binding pocket; other site
1234378003175	catalytic residue [active]
1234378003176	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1234378003177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378003178	Walker A motif; other site
1234378003179	ATP binding site [chemical binding]; other site
1234378003180	Walker B motif; other site
1234378003181	arginine finger; other site
1234378003182	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1234378003183	hypothetical protein; Validated; Region: PRK00153
1234378003184	recombination protein RecR; Reviewed; Region: recR; PRK00076
1234378003185	RecR protein; Region: RecR; pfam02132
1234378003186	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1234378003187	putative active site [active]
1234378003188	putative metal-binding site [ion binding]; other site
1234378003189	tetramer interface [polypeptide binding]; other site
1234378003190	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1234378003191	active site
1234378003192	substrate binding site [chemical binding]; other site
1234378003193	catalytic site [active]
1234378003194	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1234378003195	Peptidase family M23; Region: Peptidase_M23; pfam01551
1234378003196	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1234378003197	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1234378003198	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1234378003199	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1234378003200	AIR carboxylase; Region: AIRC; pfam00731
1234378003201	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1234378003202	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1234378003203	Catalytic site [active]
1234378003204	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1234378003205	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1234378003206	Sulfatase; Region: Sulfatase; cl17466
1234378003207	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1234378003208	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1234378003209	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1234378003210	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1234378003211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1234378003212	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1234378003213	active site
1234378003214	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1234378003215	peripheral dimer interface [polypeptide binding]; other site
1234378003216	core dimer interface [polypeptide binding]; other site
1234378003217	L10 interface [polypeptide binding]; other site
1234378003218	L11 interface [polypeptide binding]; other site
1234378003219	putative EF-Tu interaction site [polypeptide binding]; other site
1234378003220	putative EF-G interaction site [polypeptide binding]; other site
1234378003221	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1234378003222	23S rRNA interface [nucleotide binding]; other site
1234378003223	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1234378003224	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1234378003225	mRNA/rRNA interface [nucleotide binding]; other site
1234378003226	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1234378003227	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1234378003228	23S rRNA interface [nucleotide binding]; other site
1234378003229	L7/L12 interface [polypeptide binding]; other site
1234378003230	putative thiostrepton binding site; other site
1234378003231	L25 interface [polypeptide binding]; other site
1234378003232	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1234378003233	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1234378003234	putative homodimer interface [polypeptide binding]; other site
1234378003235	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1234378003236	heterodimer interface [polypeptide binding]; other site
1234378003237	homodimer interface [polypeptide binding]; other site
1234378003238	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1234378003239	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1234378003240	elongation factor Tu; Reviewed; Region: PRK00049
1234378003241	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1234378003242	G1 box; other site
1234378003243	GEF interaction site [polypeptide binding]; other site
1234378003244	GTP/Mg2+ binding site [chemical binding]; other site
1234378003245	Switch I region; other site
1234378003246	G2 box; other site
1234378003247	G3 box; other site
1234378003248	Switch II region; other site
1234378003249	G4 box; other site
1234378003250	G5 box; other site
1234378003251	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1234378003252	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1234378003253	Antibiotic Binding Site [chemical binding]; other site
1234378003254	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1234378003255	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1234378003256	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1234378003257	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1234378003258	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1234378003259	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
1234378003260	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
1234378003261	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1234378003262	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1234378003263	active site
1234378003264	tetramer interface [polypeptide binding]; other site
1234378003265	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1234378003266	active site
1234378003267	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1234378003268	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1234378003269	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1234378003270	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1234378003271	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1234378003272	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1234378003273	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1234378003274	IMP binding site; other site
1234378003275	dimer interface [polypeptide binding]; other site
1234378003276	partial ornithine binding site; other site
1234378003277	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1234378003278	nudix motif; other site
1234378003279	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1234378003280	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1234378003281	Transporter associated domain; Region: CorC_HlyC; smart01091
1234378003282	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1234378003283	S17 interaction site [polypeptide binding]; other site
1234378003284	S8 interaction site; other site
1234378003285	16S rRNA interaction site [nucleotide binding]; other site
1234378003286	streptomycin interaction site [chemical binding]; other site
1234378003287	23S rRNA interaction site [nucleotide binding]; other site
1234378003288	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1234378003289	30S ribosomal protein S7; Validated; Region: PRK05302
1234378003290	elongation factor G; Reviewed; Region: PRK00007
1234378003291	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1234378003292	G1 box; other site
1234378003293	putative GEF interaction site [polypeptide binding]; other site
1234378003294	GTP/Mg2+ binding site [chemical binding]; other site
1234378003295	Switch I region; other site
1234378003296	G2 box; other site
1234378003297	G3 box; other site
1234378003298	Switch II region; other site
1234378003299	G4 box; other site
1234378003300	G5 box; other site
1234378003301	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1234378003302	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1234378003303	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1234378003304	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1234378003305	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1234378003306	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1234378003307	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1234378003308	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1234378003309	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1234378003310	NlpC/P60 family; Region: NLPC_P60; pfam00877
1234378003311	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378003312	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378003313	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1234378003314	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1234378003315	homodimer interface [polypeptide binding]; other site
1234378003316	substrate-cofactor binding pocket; other site
1234378003317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378003318	catalytic residue [active]
1234378003319	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1234378003320	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1234378003321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378003322	TPR repeat; Region: TPR_11; pfam13414
1234378003323	binding surface
1234378003324	TPR motif; other site
1234378003325	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1234378003326	CcmB protein; Region: CcmB; cl17444
1234378003327	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1234378003328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378003329	Walker A/P-loop; other site
1234378003330	ATP binding site [chemical binding]; other site
1234378003331	Q-loop/lid; other site
1234378003332	ABC transporter signature motif; other site
1234378003333	Walker B; other site
1234378003334	D-loop; other site
1234378003335	H-loop/switch region; other site
1234378003336	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1234378003337	CcmE; Region: CcmE; cl00994
1234378003338	Domain of unknown function DUF21; Region: DUF21; pfam01595
1234378003339	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1234378003340	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1234378003341	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
1234378003342	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1234378003343	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1234378003344	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1234378003345	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1234378003346	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1234378003347	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1234378003348	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1234378003349	putative translocon binding site; other site
1234378003350	protein-rRNA interface [nucleotide binding]; other site
1234378003351	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1234378003352	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1234378003353	G-X-X-G motif; other site
1234378003354	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1234378003355	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1234378003356	23S rRNA interface [nucleotide binding]; other site
1234378003357	5S rRNA interface [nucleotide binding]; other site
1234378003358	putative antibiotic binding site [chemical binding]; other site
1234378003359	L25 interface [polypeptide binding]; other site
1234378003360	L27 interface [polypeptide binding]; other site
1234378003361	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1234378003362	trigger factor interaction site; other site
1234378003363	23S rRNA interface [nucleotide binding]; other site
1234378003364	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1234378003365	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1234378003366	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1234378003367	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1234378003368	RNA binding site [nucleotide binding]; other site
1234378003369	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1234378003370	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1234378003371	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1234378003372	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1234378003373	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1234378003374	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1234378003375	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1234378003376	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1234378003377	5S rRNA interface [nucleotide binding]; other site
1234378003378	L27 interface [polypeptide binding]; other site
1234378003379	23S rRNA interface [nucleotide binding]; other site
1234378003380	L5 interface [polypeptide binding]; other site
1234378003381	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1234378003382	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1234378003383	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1234378003384	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1234378003385	23S rRNA binding site [nucleotide binding]; other site
1234378003386	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1234378003387	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1234378003388	SecY translocase; Region: SecY; pfam00344
1234378003389	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1234378003390	active site
1234378003391	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1234378003392	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1234378003393	30S ribosomal protein S11; Validated; Region: PRK05309
1234378003394	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1234378003395	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1234378003396	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1234378003397	RNA binding surface [nucleotide binding]; other site
1234378003398	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1234378003399	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1234378003400	alphaNTD - beta interaction site [polypeptide binding]; other site
1234378003401	alphaNTD homodimer interface [polypeptide binding]; other site
1234378003402	alphaNTD - beta' interaction site [polypeptide binding]; other site
1234378003403	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1234378003404	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1234378003405	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1234378003406	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1234378003407	Substrate binding site; other site
1234378003408	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1234378003409	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1234378003410	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1234378003411	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1234378003412	dimer interface [polypeptide binding]; other site
1234378003413	motif 1; other site
1234378003414	active site
1234378003415	motif 2; other site
1234378003416	motif 3; other site
1234378003417	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1234378003418	anticodon binding site; other site
1234378003419	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1234378003420	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1234378003421	dimer interface [polypeptide binding]; other site
1234378003422	anticodon binding site; other site
1234378003423	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1234378003424	homodimer interface [polypeptide binding]; other site
1234378003425	motif 1; other site
1234378003426	active site
1234378003427	motif 2; other site
1234378003428	GAD domain; Region: GAD; pfam02938
1234378003429	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1234378003430	active site
1234378003431	motif 3; other site
1234378003432	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1234378003433	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1234378003434	Walker A/P-loop; other site
1234378003435	ATP binding site [chemical binding]; other site
1234378003436	Q-loop/lid; other site
1234378003437	ABC transporter signature motif; other site
1234378003438	Walker B; other site
1234378003439	D-loop; other site
1234378003440	H-loop/switch region; other site
1234378003441	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1234378003442	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1234378003443	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1234378003444	Ligand binding site; other site
1234378003445	oligomer interface; other site
1234378003446	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1234378003447	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1234378003448	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1234378003449	catalytic site [active]
1234378003450	subunit interface [polypeptide binding]; other site
1234378003451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378003452	binding surface
1234378003453	TPR motif; other site
1234378003454	TPR repeat; Region: TPR_11; pfam13414
1234378003455	TPR repeat; Region: TPR_11; pfam13414
1234378003456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378003457	binding surface
1234378003458	TPR motif; other site
1234378003459	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1234378003460	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1234378003461	HlyD family secretion protein; Region: HlyD_3; pfam13437
1234378003462	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1234378003463	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1234378003464	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1234378003465	adenylosuccinate lyase; Provisional; Region: PRK07492
1234378003466	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1234378003467	tetramer interface [polypeptide binding]; other site
1234378003468	active site
1234378003469	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
1234378003470	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1234378003471	active site
1234378003472	SnoaL-like domain; Region: SnoaL_3; pfam13474
1234378003473	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1234378003474	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1234378003475	Cytochrome c552; Region: Cytochrom_C552; pfam02335
1234378003476	aspartate kinase; Reviewed; Region: PRK06635
1234378003477	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
1234378003478	putative catalytic residues [active]
1234378003479	putative nucleotide binding site [chemical binding]; other site
1234378003480	putative aspartate binding site [chemical binding]; other site
1234378003481	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1234378003482	putative allosteric regulatory site; other site
1234378003483	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1234378003484	putative allosteric regulatory residue; other site
1234378003485	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1234378003486	AAA domain; Region: AAA_22; pfam13401
1234378003487	tRNA pseudouridine synthase B; Provisional; Region: PRK14124
1234378003488	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1234378003489	RNA binding site [nucleotide binding]; other site
1234378003490	active site
1234378003491	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1234378003492	16S/18S rRNA binding site [nucleotide binding]; other site
1234378003493	S13e-L30e interaction site [polypeptide binding]; other site
1234378003494	25S rRNA binding site [nucleotide binding]; other site
1234378003495	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1234378003496	polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591
1234378003497	RNase E interface [polypeptide binding]; other site
1234378003498	trimer interface [polypeptide binding]; other site
1234378003499	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1234378003500	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1234378003501	RNase E interface [polypeptide binding]; other site
1234378003502	trimer interface [polypeptide binding]; other site
1234378003503	active site
1234378003504	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1234378003505	putative nucleic acid binding region [nucleotide binding]; other site
1234378003506	G-X-X-G motif; other site
1234378003507	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1234378003508	RNA binding site [nucleotide binding]; other site
1234378003509	domain interface; other site
1234378003510	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1234378003511	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1234378003512	GatB domain; Region: GatB_Yqey; smart00845
1234378003513	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1234378003514	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
1234378003515	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1234378003516	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1234378003517	dimer interface [polypeptide binding]; other site
1234378003518	active site
1234378003519	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1234378003520	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1234378003521	domain interfaces; other site
1234378003522	active site
1234378003523	AAA domain; Region: AAA_32; pfam13654
1234378003524	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1234378003525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378003526	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1234378003527	putative substrate translocation pore; other site
1234378003528	Oligomerisation domain; Region: Oligomerisation; pfam02410
1234378003529	phosphoglyceromutase; Provisional; Region: PRK05434
1234378003530	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1234378003531	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
1234378003532	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1234378003533	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1234378003534	putative active site [active]
1234378003535	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1234378003536	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1234378003537	active site
1234378003538	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1234378003539	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1234378003540	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1234378003541	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1234378003542	trimer interface [polypeptide binding]; other site
1234378003543	active site
1234378003544	UDP-GlcNAc binding site [chemical binding]; other site
1234378003545	lipid binding site [chemical binding]; lipid-binding site
1234378003546	periplasmic chaperone; Provisional; Region: PRK10780
1234378003547	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1234378003548	TPR repeat; Region: TPR_11; pfam13414
1234378003549	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1234378003550	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1234378003551	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1234378003552	active site
1234378003553	metal binding site [ion binding]; metal-binding site
1234378003554	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1234378003555	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1234378003556	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1234378003557	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1234378003558	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1234378003559	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1234378003560	Surface antigen; Region: Bac_surface_Ag; pfam01103
1234378003561	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1234378003562	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1234378003563	Walker A/P-loop; other site
1234378003564	ATP binding site [chemical binding]; other site
1234378003565	Q-loop/lid; other site
1234378003566	ABC transporter signature motif; other site
1234378003567	Walker B; other site
1234378003568	D-loop; other site
1234378003569	H-loop/switch region; other site
1234378003570	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1234378003571	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1234378003572	FtsX-like permease family; Region: FtsX; pfam02687
1234378003573	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1234378003574	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1234378003575	dimer interface [polypeptide binding]; other site
1234378003576	putative anticodon binding site; other site
1234378003577	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1234378003578	motif 1; other site
1234378003579	active site
1234378003580	motif 2; other site
1234378003581	motif 3; other site
1234378003582	PBP superfamily domain; Region: PBP_like_2; cl17296
1234378003583	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1234378003584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378003585	dimer interface [polypeptide binding]; other site
1234378003586	conserved gate region; other site
1234378003587	putative PBP binding loops; other site
1234378003588	ABC-ATPase subunit interface; other site
1234378003589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1234378003590	dimer interface [polypeptide binding]; other site
1234378003591	conserved gate region; other site
1234378003592	putative PBP binding loops; other site
1234378003593	ABC-ATPase subunit interface; other site
1234378003594	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
1234378003595	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1234378003596	Walker A/P-loop; other site
1234378003597	ATP binding site [chemical binding]; other site
1234378003598	Q-loop/lid; other site
1234378003599	ABC transporter signature motif; other site
1234378003600	Walker B; other site
1234378003601	D-loop; other site
1234378003602	H-loop/switch region; other site
1234378003603	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
1234378003604	Pleckstrin homology-like domain; Region: PH-like; cl17171
1234378003605	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1234378003606	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1234378003607	putative ligand binding site [chemical binding]; other site
1234378003608	putative NAD binding site [chemical binding]; other site
1234378003609	catalytic site [active]
1234378003610	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1234378003611	mce related protein; Region: MCE; pfam02470
1234378003612	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1234378003613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378003614	Walker A/P-loop; other site
1234378003615	ATP binding site [chemical binding]; other site
1234378003616	Q-loop/lid; other site
1234378003617	ABC transporter signature motif; other site
1234378003618	Walker B; other site
1234378003619	D-loop; other site
1234378003620	H-loop/switch region; other site
1234378003621	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1234378003622	Permease; Region: Permease; pfam02405
1234378003623	GrpE; Region: GrpE; pfam01025
1234378003624	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1234378003625	dimer interface [polypeptide binding]; other site
1234378003626	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1234378003627	Trm112p-like protein; Region: Trm112p; cl01066
1234378003628	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1234378003629	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1234378003630	active site
1234378003631	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1234378003632	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1234378003633	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1234378003634	active site
1234378003635	HIGH motif; other site
1234378003636	nucleotide binding site [chemical binding]; other site
1234378003637	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1234378003638	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1234378003639	active site
1234378003640	KMSKS motif; other site
1234378003641	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1234378003642	tRNA binding surface [nucleotide binding]; other site
1234378003643	anticodon binding site; other site
1234378003644	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1234378003645	lipoprotein signal peptidase; Provisional; Region: PRK14787
1234378003646	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1234378003647	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1234378003648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378003649	binding surface
1234378003650	TPR motif; other site
1234378003651	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
1234378003652	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
1234378003653	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1234378003654	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
1234378003655	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1234378003656	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1234378003657	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1234378003658	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1234378003659	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1234378003660	CoA binding domain; Region: CoA_binding; smart00881
1234378003661	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
1234378003662	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1234378003663	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1234378003664	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1234378003665	dimerization interface 3.5A [polypeptide binding]; other site
1234378003666	active site
1234378003667	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1234378003668	4Fe-4S binding domain; Region: Fer4; cl02805
1234378003669	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1234378003670	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1234378003671	NADP binding site [chemical binding]; other site
1234378003672	active site
1234378003673	putative substrate binding site [chemical binding]; other site
1234378003674	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1234378003675	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1234378003676	NAD binding site [chemical binding]; other site
1234378003677	substrate binding site [chemical binding]; other site
1234378003678	homodimer interface [polypeptide binding]; other site
1234378003679	active site
1234378003680	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
1234378003681	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1234378003682	active site
1234378003683	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1234378003684	active site
1234378003685	Ribonuclease P; Region: Ribonuclease_P; cl00457
1234378003686	Uncharacterized conserved protein [Function unknown]; Region: COG0759
1234378003687	membrane protein insertase; Provisional; Region: PRK01318
1234378003688	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1234378003689	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1234378003690	G-X-X-G motif; other site
1234378003691	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1234378003692	RxxxH motif; other site
1234378003693	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1234378003694	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1234378003695	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1234378003696	G1 box; other site
1234378003697	GTP/Mg2+ binding site [chemical binding]; other site
1234378003698	Switch I region; other site
1234378003699	G2 box; other site
1234378003700	Switch II region; other site
1234378003701	G3 box; other site
1234378003702	G4 box; other site
1234378003703	G5 box; other site
1234378003704	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1234378003705	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
1234378003706	catalytic site [active]
1234378003707	putative active site [active]
1234378003708	putative substrate binding site [chemical binding]; other site
1234378003709	probable DNA repair protein; Region: TIGR03623
1234378003710	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1234378003711	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1234378003712	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1234378003713	FMN binding site [chemical binding]; other site
1234378003714	substrate binding site [chemical binding]; other site
1234378003715	putative catalytic residue [active]
1234378003716	Glucokinase; Region: Glucokinase; cl17310
1234378003717	glucokinase, proteobacterial type; Region: glk; TIGR00749
1234378003718	SprA-related family; Region: SprA-related; pfam12118
1234378003719	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1234378003720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1234378003721	putative active site [active]
1234378003722	heme pocket [chemical binding]; other site
1234378003723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1234378003724	dimer interface [polypeptide binding]; other site
1234378003725	phosphorylation site [posttranslational modification]
1234378003726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378003727	ATP binding site [chemical binding]; other site
1234378003728	Mg2+ binding site [ion binding]; other site
1234378003729	G-X-G motif; other site
1234378003730	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1234378003731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003732	active site
1234378003733	phosphorylation site [posttranslational modification]
1234378003734	intermolecular recognition site; other site
1234378003735	dimerization interface [polypeptide binding]; other site
1234378003736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378003737	Walker A motif; other site
1234378003738	ATP binding site [chemical binding]; other site
1234378003739	Walker B motif; other site
1234378003740	arginine finger; other site
1234378003741	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1234378003742	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1234378003743	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1234378003744	Walker A/P-loop; other site
1234378003745	ATP binding site [chemical binding]; other site
1234378003746	Q-loop/lid; other site
1234378003747	ABC transporter signature motif; other site
1234378003748	Walker B; other site
1234378003749	D-loop; other site
1234378003750	H-loop/switch region; other site
1234378003751	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1234378003752	FeoA domain; Region: FeoA; pfam04023
1234378003753	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1234378003754	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1234378003755	G1 box; other site
1234378003756	GTP/Mg2+ binding site [chemical binding]; other site
1234378003757	Switch I region; other site
1234378003758	G2 box; other site
1234378003759	G3 box; other site
1234378003760	Switch II region; other site
1234378003761	G4 box; other site
1234378003762	G5 box; other site
1234378003763	Nucleoside recognition; Region: Gate; pfam07670
1234378003764	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1234378003765	Nucleoside recognition; Region: Gate; pfam07670
1234378003766	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
1234378003767	Cysteine-rich domain; Region: CCG; pfam02754
1234378003768	Cysteine-rich domain; Region: CCG; pfam02754
1234378003769	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1234378003770	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1234378003771	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
1234378003772	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1234378003773	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
1234378003774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378003775	S-adenosylmethionine binding site [chemical binding]; other site
1234378003776	nickel responsive regulator; Provisional; Region: PRK04460
1234378003777	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1234378003778	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1234378003779	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1234378003780	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1234378003781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378003782	Walker A motif; other site
1234378003783	ATP binding site [chemical binding]; other site
1234378003784	Walker B motif; other site
1234378003785	arginine finger; other site
1234378003786	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1234378003787	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1234378003788	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1234378003789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378003790	binding surface
1234378003791	TPR motif; other site
1234378003792	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1234378003793	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378003794	Zn2+ binding site [ion binding]; other site
1234378003795	Mg2+ binding site [ion binding]; other site
1234378003796	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
1234378003797	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1234378003798	domain interfaces; other site
1234378003799	active site
1234378003800	cell division protein MraZ; Reviewed; Region: PRK00326
1234378003801	MraZ protein; Region: MraZ; pfam02381
1234378003802	MraZ protein; Region: MraZ; pfam02381
1234378003803	MraW methylase family; Region: Methyltransf_5; pfam01795
1234378003804	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1234378003805	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1234378003806	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1234378003807	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1234378003808	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1234378003809	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1234378003810	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1234378003811	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1234378003812	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1234378003813	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1234378003814	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1234378003815	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1234378003816	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1234378003817	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1234378003818	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1234378003819	Mg++ binding site [ion binding]; other site
1234378003820	putative catalytic motif [active]
1234378003821	putative substrate binding site [chemical binding]; other site
1234378003822	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
1234378003823	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1234378003824	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1234378003825	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1234378003826	cell division protein FtsW; Region: ftsW; TIGR02614
1234378003827	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1234378003828	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1234378003829	active site
1234378003830	homodimer interface [polypeptide binding]; other site
1234378003831	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1234378003832	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1234378003833	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1234378003834	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1234378003835	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
1234378003836	FAD binding domain; Region: FAD_binding_4; pfam01565
1234378003837	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1234378003838	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1234378003839	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1234378003840	cell division protein FtsA; Region: ftsA; TIGR01174
1234378003841	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1234378003842	nucleotide binding site [chemical binding]; other site
1234378003843	Cell division protein FtsA; Region: FtsA; pfam14450
1234378003844	cell division protein FtsZ; Validated; Region: PRK09330
1234378003845	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1234378003846	nucleotide binding site [chemical binding]; other site
1234378003847	SulA interaction site; other site
1234378003848	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
1234378003849	putative active site [active]
1234378003850	putative metal binding residues [ion binding]; other site
1234378003851	signature motif; other site
1234378003852	putative dimer interface [polypeptide binding]; other site
1234378003853	putative phosphate binding site [ion binding]; other site
1234378003854	DNA utilization protein GntX; Provisional; Region: PRK11595
1234378003855	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1234378003856	active site
1234378003857	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1234378003858	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1234378003859	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1234378003860	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1234378003861	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1234378003862	periplasmic folding chaperone; Provisional; Region: PRK10788
1234378003863	SurA N-terminal domain; Region: SurA_N_3; cl07813
1234378003864	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1234378003865	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1234378003866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003867	active site
1234378003868	phosphorylation site [posttranslational modification]
1234378003869	intermolecular recognition site; other site
1234378003870	dimerization interface [polypeptide binding]; other site
1234378003871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378003872	Walker A motif; other site
1234378003873	ATP binding site [chemical binding]; other site
1234378003874	Walker B motif; other site
1234378003875	arginine finger; other site
1234378003876	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1234378003877	hybrid cluster protein; Provisional; Region: PRK05290
1234378003878	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1234378003879	ACS interaction site; other site
1234378003880	CODH interaction site; other site
1234378003881	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1234378003882	ACS interaction site; other site
1234378003883	CODH interaction site; other site
1234378003884	metal cluster binding site [ion binding]; other site
1234378003885	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1234378003886	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1234378003887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003888	active site
1234378003889	phosphorylation site [posttranslational modification]
1234378003890	intermolecular recognition site; other site
1234378003891	dimerization interface [polypeptide binding]; other site
1234378003892	LabA_like proteins; Region: LabA_like/DUF88; cl10034
1234378003893	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
1234378003894	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1234378003895	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1234378003896	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1234378003897	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1234378003898	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1234378003899	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1234378003900	active site
1234378003901	multimer interface [polypeptide binding]; other site
1234378003902	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1234378003903	NodB motif; other site
1234378003904	putative active site [active]
1234378003905	putative catalytic site [active]
1234378003906	Zn binding site [ion binding]; other site
1234378003907	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1234378003908	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1234378003909	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1234378003910	protein binding site [polypeptide binding]; other site
1234378003911	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1234378003912	Catalytic dyad [active]
1234378003913	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1234378003914	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1234378003915	minor groove reading motif; other site
1234378003916	helix-hairpin-helix signature motif; other site
1234378003917	substrate binding pocket [chemical binding]; other site
1234378003918	active site
1234378003919	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1234378003920	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1234378003921	metal-binding site [ion binding]
1234378003922	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1234378003923	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1234378003924	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1234378003925	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1234378003926	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1234378003927	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
1234378003928	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1234378003929	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1234378003930	Walker A/P-loop; other site
1234378003931	ATP binding site [chemical binding]; other site
1234378003932	Q-loop/lid; other site
1234378003933	ABC transporter signature motif; other site
1234378003934	Walker B; other site
1234378003935	D-loop; other site
1234378003936	H-loop/switch region; other site
1234378003937	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1234378003938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378003939	S-adenosylmethionine binding site [chemical binding]; other site
1234378003940	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1234378003941	triosephosphate isomerase; Provisional; Region: PRK14565
1234378003942	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1234378003943	substrate binding site [chemical binding]; other site
1234378003944	dimer interface [polypeptide binding]; other site
1234378003945	catalytic triad [active]
1234378003946	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1234378003947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1234378003948	Coenzyme A binding pocket [chemical binding]; other site
1234378003949	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1234378003950	nudix motif; other site
1234378003951	rod shape-determining protein MreB; Provisional; Region: PRK13930
1234378003952	MreB and similar proteins; Region: MreB_like; cd10225
1234378003953	nucleotide binding site [chemical binding]; other site
1234378003954	Mg binding site [ion binding]; other site
1234378003955	putative protofilament interaction site [polypeptide binding]; other site
1234378003956	RodZ interaction site [polypeptide binding]; other site
1234378003957	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1234378003958	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1234378003959	GAF domain; Region: GAF; pfam01590
1234378003960	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1234378003961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003962	active site
1234378003963	phosphorylation site [posttranslational modification]
1234378003964	intermolecular recognition site; other site
1234378003965	CheB methylesterase; Region: CheB_methylest; pfam01339
1234378003966	HEAT repeats; Region: HEAT_2; pfam13646
1234378003967	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
1234378003968	protein binding surface [polypeptide binding]; other site
1234378003969	HEAT repeats; Region: HEAT_2; pfam13646
1234378003970	HEAT repeats; Region: HEAT_2; pfam13646
1234378003971	HEAT repeats; Region: HEAT_2; pfam13646
1234378003972	HEAT repeats; Region: HEAT_2; pfam13646
1234378003973	HEAT repeats; Region: HEAT_2; pfam13646
1234378003974	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1234378003975	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1234378003976	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1234378003977	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1234378003978	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378003979	P-loop; other site
1234378003980	Magnesium ion binding site [ion binding]; other site
1234378003981	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378003982	Magnesium ion binding site [ion binding]; other site
1234378003983	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1234378003984	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1234378003985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1234378003986	active site
1234378003987	phosphorylation site [posttranslational modification]
1234378003988	intermolecular recognition site; other site
1234378003989	dimerization interface [polypeptide binding]; other site
1234378003990	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1234378003991	putative binding surface; other site
1234378003992	active site
1234378003993	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1234378003994	putative binding surface; other site
1234378003995	active site
1234378003996	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1234378003997	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1234378003998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1234378003999	ATP binding site [chemical binding]; other site
1234378004000	Mg2+ binding site [ion binding]; other site
1234378004001	G-X-G motif; other site
1234378004002	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1234378004003	HAMP domain; Region: HAMP; pfam00672
1234378004004	dimerization interface [polypeptide binding]; other site
1234378004005	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1234378004006	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1234378004007	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1234378004008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378004009	Walker A motif; other site
1234378004010	ATP binding site [chemical binding]; other site
1234378004011	Walker B motif; other site
1234378004012	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1234378004013	HrpJ-like domain; Region: HrpJ; pfam07201
1234378004014	TyeA; Region: TyeA; pfam09059
1234378004015	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
1234378004016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1234378004017	binding surface
1234378004018	TPR motif; other site
1234378004019	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
1234378004020	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
1234378004021	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1234378004022	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1234378004023	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
1234378004024	FHA domain; Region: FHA; pfam00498
1234378004025	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1234378004026	type III secretion system protein; Reviewed; Region: PRK06937
1234378004027	Flagellar assembly protein FliH; Region: FliH; pfam02108
1234378004028	type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514
1234378004029	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1234378004030	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1234378004031	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1234378004032	anti sigma factor interaction site; other site
1234378004033	regulatory phosphorylation site [posttranslational modification]; other site
1234378004034	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1234378004035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1234378004036	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1234378004037	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1234378004038	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1234378004039	catalytic residue [active]
1234378004040	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1234378004041	putative CheA interaction surface; other site
1234378004042	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1234378004043	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1234378004044	active site
1234378004045	metal binding site [ion binding]; metal-binding site
1234378004046	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1234378004047	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
1234378004048	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1234378004049	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1234378004050	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1234378004051	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1234378004052	catalytic residue [active]
1234378004053	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1234378004054	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1234378004055	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1234378004056	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1234378004057	FMN binding site [chemical binding]; other site
1234378004058	dimer interface [polypeptide binding]; other site
1234378004059	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1234378004060	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1234378004061	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1234378004062	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1234378004063	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1234378004064	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1234378004065	Walker A/P-loop; other site
1234378004066	ATP binding site [chemical binding]; other site
1234378004067	Q-loop/lid; other site
1234378004068	ABC transporter signature motif; other site
1234378004069	Walker B; other site
1234378004070	D-loop; other site
1234378004071	H-loop/switch region; other site
1234378004072	BioY family; Region: BioY; pfam02632
1234378004073	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1234378004074	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1234378004075	motif 1; other site
1234378004076	active site
1234378004077	motif 2; other site
1234378004078	motif 3; other site
1234378004079	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1234378004080	DHHA1 domain; Region: DHHA1; pfam02272
1234378004081	recombinase A; Provisional; Region: recA; PRK09354
1234378004082	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1234378004083	hexamer interface [polypeptide binding]; other site
1234378004084	Walker A motif; other site
1234378004085	ATP binding site [chemical binding]; other site
1234378004086	Walker B motif; other site
1234378004087	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1234378004088	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1234378004089	HIGH motif; other site
1234378004090	active site
1234378004091	KMSKS motif; other site
1234378004092	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1234378004093	tRNA binding surface [nucleotide binding]; other site
1234378004094	anticodon binding site; other site
1234378004095	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1234378004096	dimer interface [polypeptide binding]; other site
1234378004097	putative tRNA-binding site [nucleotide binding]; other site
1234378004098	PSP1 C-terminal conserved region; Region: PSP1; cl00770
1234378004099	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602
1234378004100	RuvA N terminal domain; Region: RuvA_N; pfam01330
1234378004101	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1234378004102	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1234378004103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1234378004104	Walker A motif; other site
1234378004105	ATP binding site [chemical binding]; other site
1234378004106	Walker B motif; other site
1234378004107	arginine finger; other site
1234378004108	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1234378004109	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1234378004110	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1234378004111	active site
1234378004112	catalytic residues [active]
1234378004113	DNA binding site [nucleotide binding]
1234378004114	Int/Topo IB signature motif; other site
1234378004115	Uncharacterized conserved protein [Function unknown]; Region: COG3347
1234378004116	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1234378004117	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1234378004118	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1234378004119	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1234378004120	active site
1234378004121	Substrate binding site; other site
1234378004122	Mg++ binding site; other site
1234378004123	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
1234378004124	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1234378004125	active site
1234378004126	motif I; other site
1234378004127	motif II; other site
1234378004128	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1234378004129	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1234378004130	active site
1234378004131	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1234378004132	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1234378004133	S-adenosylmethionine binding site [chemical binding]; other site
1234378004134	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1234378004135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004136	S-adenosylmethionine binding site [chemical binding]; other site
1234378004137	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1234378004138	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004139	S-adenosylmethionine binding site [chemical binding]; other site
1234378004140	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1234378004141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004142	S-adenosylmethionine binding site [chemical binding]; other site
1234378004143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378004144	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1234378004145	FeS/SAM binding site; other site
1234378004146	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
1234378004147	B12 binding domain; Region: B12-binding; pfam02310
1234378004148	B12 binding site [chemical binding]; other site
1234378004149	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378004150	FeS/SAM binding site; other site
1234378004151	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1234378004152	dimer interface [polypeptide binding]; other site
1234378004153	active site
1234378004154	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1234378004155	DXD motif; other site
1234378004156	Putative Catalytic site; other site
1234378004157	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1234378004158	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1234378004159	NAD binding site [chemical binding]; other site
1234378004160	homodimer interface [polypeptide binding]; other site
1234378004161	active site
1234378004162	substrate binding site [chemical binding]; other site
1234378004163	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1234378004164	Ligand binding site; other site
1234378004165	Putative Catalytic site; other site
1234378004166	DXD motif; other site
1234378004167	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1234378004168	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1234378004169	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1234378004170	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1234378004171	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004172	P-loop; other site
1234378004173	Magnesium ion binding site [ion binding]; other site
1234378004174	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004175	Magnesium ion binding site [ion binding]; other site
1234378004176	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1234378004177	Predicted transcriptional regulator [Transcription]; Region: COG3905
1234378004178	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1234378004179	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1234378004180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1234378004181	non-specific DNA binding site [nucleotide binding]; other site
1234378004182	salt bridge; other site
1234378004183	sequence-specific DNA binding site [nucleotide binding]; other site
1234378004184	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1234378004185	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1234378004186	Zn2+ binding site [ion binding]; other site
1234378004187	Mg2+ binding site [ion binding]; other site
1234378004188	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004189	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1234378004190	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1234378004191	active site
1234378004192	dimer interface [polypeptide binding]; other site
1234378004193	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1234378004194	Ligand Binding Site [chemical binding]; other site
1234378004195	Molecular Tunnel; other site
1234378004196	Catalytic domain of a putative polysaccharide deacetylase WbmS from Bordetella bronchiseptica and similar proteins; Region: CE4_WbmS; cd10920
1234378004197	active site
1234378004198	Zn binding site [ion binding]; other site
1234378004199	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1234378004200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004201	S-adenosylmethionine binding site [chemical binding]; other site
1234378004202	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1234378004203	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1234378004204	inhibitor-cofactor binding pocket; inhibition site
1234378004205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378004206	catalytic residue [active]
1234378004207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378004208	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1234378004209	FeS/SAM binding site; other site
1234378004210	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1234378004211	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1234378004212	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1234378004213	putative trimer interface [polypeptide binding]; other site
1234378004214	putative CoA binding site [chemical binding]; other site
1234378004215	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1234378004216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004217	S-adenosylmethionine binding site [chemical binding]; other site
1234378004218	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004219	S-adenosylmethionine binding site [chemical binding]; other site
1234378004220	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1234378004221	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1234378004222	inhibitor-cofactor binding pocket; inhibition site
1234378004223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378004224	catalytic residue [active]
1234378004225	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
1234378004226	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1234378004227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1234378004228	FeS/SAM binding site; other site
1234378004229	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1234378004230	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1234378004231	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1234378004232	Phage integrase family; Region: Phage_integrase; pfam00589
1234378004233	active site
1234378004234	DNA binding site [nucleotide binding]
1234378004235	Int/Topo IB signature motif; other site
1234378004236	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1234378004237	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004238	P-loop; other site
1234378004239	Magnesium ion binding site [ion binding]; other site
1234378004240	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004241	Magnesium ion binding site [ion binding]; other site
1234378004242	Herpesvirus UL6 like; Region: Herpes_UL6; pfam01763
1234378004243	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1234378004244	active site
1234378004245	DNA binding site [nucleotide binding]
1234378004246	Int/Topo IB signature motif; other site
1234378004247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378004248	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378004249	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1234378004250	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1234378004251	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1234378004252	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1234378004253	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1234378004254	active site
1234378004255	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
1234378004256	putative ligand binding site [chemical binding]; other site
1234378004257	putative catalytic site [active]
1234378004258	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1234378004259	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378004260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1234378004261	S-adenosylmethionine binding site [chemical binding]; other site
1234378004262	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1234378004263	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
1234378004264	Substrate binding site; other site
1234378004265	Mg++ binding site; other site
1234378004266	metal-binding site
1234378004267	Mg++ binding site; other site
1234378004268	metal-binding site
1234378004269	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1234378004270	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1234378004271	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1234378004272	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1234378004273	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1234378004274	classical (c) SDRs; Region: SDR_c; cd05233
1234378004275	NAD(P) binding site [chemical binding]; other site
1234378004276	active site
1234378004277	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1234378004278	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1234378004279	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1234378004280	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1234378004281	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1234378004282	putative translaldolase; Provisional; Region: PRK12376
1234378004283	catalytic residue [active]
1234378004284	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
1234378004285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1234378004286	active site
1234378004287	motif I; other site
1234378004288	motif II; other site
1234378004289	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1234378004290	dimer interface [polypeptide binding]; other site
1234378004291	active site
1234378004292	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1234378004293	UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234
1234378004294	NAD binding site [chemical binding]; other site
1234378004295	homodimer interface [polypeptide binding]; other site
1234378004296	active site
1234378004297	putative substrate binding site [chemical binding]; other site
1234378004298	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1234378004299	Ligand binding site; other site
1234378004300	Putative Catalytic site; other site
1234378004301	DXD motif; other site
1234378004302	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1234378004303	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1234378004304	non-specific DNA binding site [nucleotide binding]; other site
1234378004305	salt bridge; other site
1234378004306	sequence-specific DNA binding site [nucleotide binding]; other site
1234378004307	Protein of unknown function (DUF1804); Region: DUF1804; pfam08822
1234378004308	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1234378004309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1234378004310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1234378004311	catalytic residue [active]
1234378004312	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1234378004314	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1234378004315	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004316	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1234378004317	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1234378004318	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004319	Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108
1234378004320	heterodimer interface [polypeptide binding]; other site
1234378004321	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004322	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004323	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004324	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004325	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004326	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004327	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004328	Autotransporter beta-domain; Region: Autotransporter; cl17461
1234378004329	Autotransporter beta-domain; Region: Autotransporter; cl17461
1234378004330	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1234378004331	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004332	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004333	Autotransporter beta-domain; Region: Autotransporter; cl17461
1234378004334	Autotransporter beta-domain; Region: Autotransporter; cl17461
1234378004335	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004336	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1234378004337	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004338	P-loop; other site
1234378004339	Magnesium ion binding site [ion binding]; other site
1234378004340	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1234378004341	Magnesium ion binding site [ion binding]; other site
1234378004342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1234378004343	DNA-binding site [nucleotide binding]; DNA binding site
1234378004344	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004345	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
1234378004346	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
1234378004347	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
1234378004348	Domain of unknown function (DUF1834); Region: DUF1834; pfam08873
1234378004349	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
1234378004350	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
1234378004351	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1234378004352	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
1234378004353	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
1234378004354	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1234378004355	homotrimer interaction site [polypeptide binding]; other site
1234378004356	putative active site [active]
1234378004357	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1234378004358	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1234378004359	NADP binding site [chemical binding]; other site
1234378004360	active site
1234378004361	putative substrate binding site [chemical binding]; other site
1234378004362	replicative DNA helicase; Region: DnaB; TIGR00665
1234378004363	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1234378004364	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1234378004365	Walker A motif; other site
1234378004366	ATP binding site [chemical binding]; other site
1234378004367	Walker B motif; other site
1234378004368	DNA binding loops [nucleotide binding]
1234378004369	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1234378004370	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1234378004371	NADP-binding site; other site
1234378004372	homotetramer interface [polypeptide binding]; other site
1234378004373	substrate binding site [chemical binding]; other site
1234378004374	homodimer interface [polypeptide binding]; other site
1234378004375	active site
1234378004376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1234378004377	non-specific DNA binding site [nucleotide binding]; other site
1234378004378	salt bridge; other site
1234378004379	sequence-specific DNA binding site [nucleotide binding]; other site
1234378004380	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
1234378004381	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1234378004382	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1234378004383	active site
1234378004384	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1234378004385	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1234378004386	Probable Catalytic site; other site
1234378004387	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1234378004388	Phage protein GP46; Region: GP46; cl01814
1234378004389	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
1234378004390	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
1234378004391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1234378004392	putative substrate translocation pore; other site
1234378004393	POT family; Region: PTR2; cl17359
1234378004394	Autotransporter beta-domain; Region: Autotransporter; smart00869
1234378004395	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
1234378004396	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1234378004397	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1234378004398	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1234378004399	putative trimer interface [polypeptide binding]; other site
1234378004400	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
1234378004401	putative CoA binding site [chemical binding]; other site
1234378004402	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1234378004403	putative trimer interface [polypeptide binding]; other site
1234378004404	putative active site [active]
1234378004405	putative substrate binding site [chemical binding]; other site
1234378004406	putative CoA binding site [chemical binding]; other site
1234378004407	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1234378004408	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1234378004409	inhibitor-cofactor binding pocket; inhibition site
1234378004410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1234378004411	catalytic residue [active]
1234378004412	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1234378004413	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1234378004414	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1234378004415	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1234378004416	dimer interface [polypeptide binding]; other site
1234378004417	putative CheW interface [polypeptide binding]; other site
1234378004418	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1234378004419	Haem-binding domain; Region: Haem_bd; pfam14376
1234378004420	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1234378004421	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1234378004422	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1234378004423	dimerization interface [polypeptide binding]; other site
1234378004424	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1234378004425	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1234378004426	dimer interface [polypeptide binding]; other site
1234378004427	putative CheW interface [polypeptide binding]; other site
1234378004428	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1234378004429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440