-- dump date 20140619_125910 -- class Genbank::misc_feature -- table misc_feature_note -- id note 363253000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 363253000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 363253000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000004 Walker A motif; other site 363253000005 ATP binding site [chemical binding]; other site 363253000006 Walker B motif; other site 363253000007 arginine finger; other site 363253000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 363253000009 DnaA box-binding interface [nucleotide binding]; other site 363253000010 peptide chain release factor 1; Validated; Region: prfA; PRK00591 363253000011 This domain is found in peptide chain release factors; Region: PCRF; smart00937 363253000012 RF-1 domain; Region: RF-1; pfam00472 363253000013 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 363253000014 S4 domain; Region: S4; pfam01479 363253000015 RNA binding surface [nucleotide binding]; other site 363253000016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253000017 S-adenosylmethionine binding site [chemical binding]; other site 363253000018 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 363253000019 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 363253000020 E-class dimer interface [polypeptide binding]; other site 363253000021 P-class dimer interface [polypeptide binding]; other site 363253000022 active site 363253000023 Cu2+ binding site [ion binding]; other site 363253000024 Zn2+ binding site [ion binding]; other site 363253000025 TLC ATP/ADP transporter; Region: TLC; pfam03219 363253000026 Alphaherpesvirus glycoprotein E; Region: Herpes_gE; pfam02480 363253000027 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 363253000028 DNA polymerase III subunit delta'; Validated; Region: PRK08485 363253000029 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 363253000030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 363253000031 putative acyl-acceptor binding pocket; other site 363253000032 recombination factor protein RarA; Reviewed; Region: PRK13342 363253000033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000034 Walker A motif; other site 363253000035 ATP binding site [chemical binding]; other site 363253000036 Walker B motif; other site 363253000037 arginine finger; other site 363253000038 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 363253000039 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 363253000040 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 363253000041 active site 363253000042 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 363253000043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 363253000044 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 363253000045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253000046 S-adenosylmethionine binding site [chemical binding]; other site 363253000047 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 363253000048 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 363253000049 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 363253000050 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 363253000051 active site 363253000052 HIGH motif; other site 363253000053 nucleotide binding site [chemical binding]; other site 363253000054 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 363253000055 active site 363253000056 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 363253000057 HIGH motif; other site 363253000058 dimer interface [polypeptide binding]; other site 363253000059 KMSKS motif; other site 363253000060 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 363253000061 Peptidase family M50; Region: Peptidase_M50; pfam02163 363253000062 active site 363253000063 putative substrate binding region [chemical binding]; other site 363253000064 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 363253000065 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 363253000066 active site 363253000067 HIGH motif; other site 363253000068 dimer interface [polypeptide binding]; other site 363253000069 KMSKS motif; other site 363253000070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 363253000071 RNA binding surface [nucleotide binding]; other site 363253000072 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 363253000073 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 363253000074 DNA binding site [nucleotide binding] 363253000075 active site 363253000076 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 363253000077 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 363253000078 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 363253000079 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 363253000080 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 363253000081 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 363253000082 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 363253000083 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 363253000084 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 363253000085 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 363253000086 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 363253000087 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 363253000088 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 363253000089 Organic solvent tolerance protein; Region: OstA_C; pfam04453 363253000090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 363253000091 alanine racemase; Reviewed; Region: alr; PRK00053 363253000092 active site 363253000093 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 363253000094 dimer interface [polypeptide binding]; other site 363253000095 substrate binding site [chemical binding]; other site 363253000096 catalytic residues [active] 363253000097 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 363253000098 metal binding site 2 [ion binding]; metal-binding site 363253000099 putative DNA binding helix; other site 363253000100 metal binding site 1 [ion binding]; metal-binding site 363253000101 dimer interface [polypeptide binding]; other site 363253000102 structural Zn2+ binding site [ion binding]; other site 363253000103 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253000104 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253000105 putative active site [active] 363253000106 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 363253000107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 363253000108 non-specific DNA binding site [nucleotide binding]; other site 363253000109 salt bridge; other site 363253000110 sequence-specific DNA binding site [nucleotide binding]; other site 363253000111 Staphylococcal nuclease homologues; Region: SNc; smart00318 363253000112 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 363253000113 Catalytic site; other site 363253000114 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 363253000115 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 363253000116 Tir chaperone protein (CesT) family; Region: CesT; cl08444 363253000117 Sulfatase; Region: Sulfatase; pfam00884 363253000118 Uncharacterized conserved protein [Function unknown]; Region: COG4748 363253000119 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 363253000120 Protein export membrane protein; Region: SecD_SecF; pfam02355 363253000121 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 363253000122 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 363253000123 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 363253000124 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 363253000125 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 363253000126 Family description; Region: UvrD_C_2; pfam13538 363253000127 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 363253000128 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 363253000129 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 363253000130 active site 363253000131 ADP/pyrophosphate binding site [chemical binding]; other site 363253000132 dimerization interface [polypeptide binding]; other site 363253000133 allosteric effector site; other site 363253000134 fructose-1,6-bisphosphate binding site; other site 363253000135 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 363253000136 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 363253000137 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 363253000138 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 363253000139 N-acetyl-D-glucosamine binding site [chemical binding]; other site 363253000140 catalytic residue [active] 363253000141 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 363253000142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 363253000143 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 363253000144 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 363253000145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 363253000146 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 363253000147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000148 dimer interface [polypeptide binding]; other site 363253000149 conserved gate region; other site 363253000150 putative PBP binding loops; other site 363253000151 ABC-ATPase subunit interface; other site 363253000152 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 363253000153 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 363253000154 Walker A/P-loop; other site 363253000155 ATP binding site [chemical binding]; other site 363253000156 Q-loop/lid; other site 363253000157 ABC transporter signature motif; other site 363253000158 Walker B; other site 363253000159 D-loop; other site 363253000160 H-loop/switch region; other site 363253000161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 363253000162 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 363253000163 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 363253000164 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 363253000165 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 363253000166 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 363253000167 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 363253000168 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 363253000169 active site 363253000170 (T/H)XGH motif; other site 363253000171 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 363253000172 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 363253000173 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 363253000174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253000175 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 363253000176 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 363253000177 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 363253000178 elongation factor P; Validated; Region: PRK00529 363253000179 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 363253000180 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 363253000181 RNA binding site [nucleotide binding]; other site 363253000182 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 363253000183 RNA binding site [nucleotide binding]; other site 363253000184 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 363253000185 G1 box; other site 363253000186 GTP/Mg2+ binding site [chemical binding]; other site 363253000187 Switch I region; other site 363253000188 G2 box; other site 363253000189 G3 box; other site 363253000190 Switch II region; other site 363253000191 G4 box; other site 363253000192 G5 box; other site 363253000193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 363253000194 active site residue [active] 363253000195 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 363253000196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 363253000197 active site 363253000198 metal binding site [ion binding]; metal-binding site 363253000199 hexamer interface [polypeptide binding]; other site 363253000200 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 363253000201 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 363253000202 Walker A/P-loop; other site 363253000203 ATP binding site [chemical binding]; other site 363253000204 Q-loop/lid; other site 363253000205 ABC transporter signature motif; other site 363253000206 Walker B; other site 363253000207 D-loop; other site 363253000208 H-loop/switch region; other site 363253000209 TOBE domain; Region: TOBE_2; pfam08402 363253000210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 363253000211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 363253000212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000213 dimer interface [polypeptide binding]; other site 363253000214 conserved gate region; other site 363253000215 putative PBP binding loops; other site 363253000216 ABC-ATPase subunit interface; other site 363253000217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 363253000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000219 dimer interface [polypeptide binding]; other site 363253000220 conserved gate region; other site 363253000221 putative PBP binding loops; other site 363253000222 ABC-ATPase subunit interface; other site 363253000223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 363253000224 NAD(P) binding site [chemical binding]; other site 363253000225 active site 363253000226 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 363253000227 KpsF/GutQ family protein; Region: kpsF; TIGR00393 363253000228 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 363253000229 putative active site [active] 363253000230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 363253000231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 363253000232 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 363253000233 Domain of unknown function (DUF386); Region: DUF386; cl01047 363253000234 acetylornithine aminotransferase; Provisional; Region: PRK02627 363253000235 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 363253000236 inhibitor-cofactor binding pocket; inhibition site 363253000237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253000238 catalytic residue [active] 363253000239 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 363253000240 trimer interface [polypeptide binding]; other site 363253000241 active site 363253000242 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 363253000243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 363253000244 nucleotide binding site [chemical binding]; other site 363253000245 Type III pantothenate kinase; Region: Pan_kinase; cl17198 363253000246 enolase; Provisional; Region: eno; PRK00077 363253000247 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 363253000248 dimer interface [polypeptide binding]; other site 363253000249 metal binding site [ion binding]; metal-binding site 363253000250 substrate binding pocket [chemical binding]; other site 363253000251 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253000252 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253000253 putative active site [active] 363253000254 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 363253000255 AAA domain; Region: AAA_33; pfam13671 363253000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 363253000257 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 363253000258 catalytic core [active] 363253000259 Tetratricopeptide repeat; Region: TPR_16; pfam13432 363253000260 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 363253000261 Cl binding site [ion binding]; other site 363253000262 oligomer interface [polypeptide binding]; other site 363253000263 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 363253000264 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 363253000265 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 363253000266 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 363253000267 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 363253000268 DNA polymerase I; Provisional; Region: PRK05755 363253000269 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 363253000270 active site 363253000271 metal binding site 1 [ion binding]; metal-binding site 363253000272 putative 5' ssDNA interaction site; other site 363253000273 metal binding site 3; metal-binding site 363253000274 metal binding site 2 [ion binding]; metal-binding site 363253000275 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 363253000276 putative DNA binding site [nucleotide binding]; other site 363253000277 putative metal binding site [ion binding]; other site 363253000278 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 363253000279 active site 363253000280 DNA binding site [nucleotide binding] 363253000281 catalytic site [active] 363253000282 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 363253000283 acetolactate synthase; Reviewed; Region: PRK08322 363253000284 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 363253000285 PYR/PP interface [polypeptide binding]; other site 363253000286 dimer interface [polypeptide binding]; other site 363253000287 TPP binding site [chemical binding]; other site 363253000288 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 363253000289 putative active site [active] 363253000290 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 363253000291 TPP-binding site [chemical binding]; other site 363253000292 dimer interface [polypeptide binding]; other site 363253000293 Membrane transport protein; Region: Mem_trans; cl09117 363253000294 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 363253000295 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 363253000296 inhibitor site; inhibition site 363253000297 active site 363253000298 dimer interface [polypeptide binding]; other site 363253000299 catalytic residue [active] 363253000300 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 363253000301 Tetratricopeptide repeat; Region: TPR_6; pfam13174 363253000302 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 363253000303 DNA protecting protein DprA; Region: dprA; TIGR00732 363253000304 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 363253000305 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 363253000306 active site 363253000307 DNA binding site [nucleotide binding] 363253000308 Int/Topo IB signature motif; other site 363253000309 Tim44-like domain; Region: Tim44; pfam04280 363253000310 GTP-binding protein Der; Reviewed; Region: PRK00093 363253000311 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 363253000312 G1 box; other site 363253000313 GTP/Mg2+ binding site [chemical binding]; other site 363253000314 Switch I region; other site 363253000315 G2 box; other site 363253000316 Switch II region; other site 363253000317 G3 box; other site 363253000318 G4 box; other site 363253000319 G5 box; other site 363253000320 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 363253000321 G1 box; other site 363253000322 GTP/Mg2+ binding site [chemical binding]; other site 363253000323 Switch I region; other site 363253000324 G2 box; other site 363253000325 G3 box; other site 363253000326 Switch II region; other site 363253000327 G4 box; other site 363253000328 G5 box; other site 363253000329 seryl-tRNA synthetase; Provisional; Region: PRK05431 363253000330 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 363253000331 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 363253000332 dimer interface [polypeptide binding]; other site 363253000333 active site 363253000334 motif 1; other site 363253000335 motif 2; other site 363253000336 motif 3; other site 363253000337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253000338 TPR motif; other site 363253000339 TPR repeat; Region: TPR_11; pfam13414 363253000340 binding surface 363253000341 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 363253000342 diphthine synthase; Region: dph5; TIGR00522 363253000343 active site 363253000344 SAM binding site [chemical binding]; other site 363253000345 homodimer interface [polypeptide binding]; other site 363253000346 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 363253000347 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 363253000348 active site 363253000349 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 363253000350 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 363253000351 active site 363253000352 substrate binding site [chemical binding]; other site 363253000353 cosubstrate binding site; other site 363253000354 catalytic site [active] 363253000355 methionine sulfoxide reductase A; Provisional; Region: PRK14054 363253000356 methionine sulfoxide reductase B; Provisional; Region: PRK05508 363253000357 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 363253000358 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 363253000359 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 363253000360 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 363253000361 maltose O-acetyltransferase; Provisional; Region: PRK10092 363253000362 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 363253000363 active site 363253000364 substrate binding site [chemical binding]; other site 363253000365 trimer interface [polypeptide binding]; other site 363253000366 CoA binding site [chemical binding]; other site 363253000367 chaperone protein DnaJ; Provisional; Region: PRK14299 363253000368 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 363253000369 HSP70 interaction site [polypeptide binding]; other site 363253000370 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 363253000371 substrate binding site [polypeptide binding]; other site 363253000372 dimer interface [polypeptide binding]; other site 363253000373 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 363253000374 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 363253000375 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 363253000376 Clp amino terminal domain; Region: Clp_N; pfam02861 363253000377 Clp amino terminal domain; Region: Clp_N; pfam02861 363253000378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000379 Walker A motif; other site 363253000380 ATP binding site [chemical binding]; other site 363253000381 Walker B motif; other site 363253000382 arginine finger; other site 363253000383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000384 Walker A motif; other site 363253000385 ATP binding site [chemical binding]; other site 363253000386 Walker B motif; other site 363253000387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 363253000388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 363253000389 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 363253000390 Walker A/P-loop; other site 363253000391 ATP binding site [chemical binding]; other site 363253000392 Q-loop/lid; other site 363253000393 ABC transporter signature motif; other site 363253000394 Walker B; other site 363253000395 D-loop; other site 363253000396 H-loop/switch region; other site 363253000397 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 363253000398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000399 dimer interface [polypeptide binding]; other site 363253000400 conserved gate region; other site 363253000401 putative PBP binding loops; other site 363253000402 ABC-ATPase subunit interface; other site 363253000403 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 363253000404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 363253000405 substrate binding pocket [chemical binding]; other site 363253000406 membrane-bound complex binding site; other site 363253000407 hinge residues; other site 363253000408 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 363253000409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 363253000410 active site 363253000411 motif I; other site 363253000412 motif II; other site 363253000413 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 363253000414 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 363253000415 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 363253000416 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 363253000417 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 363253000418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 363253000419 catalytic residue [active] 363253000420 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 363253000421 anti sigma factor interaction site; other site 363253000422 regulatory phosphorylation site [posttranslational modification]; other site 363253000423 Protein of unknown function (DUF342); Region: DUF342; pfam03961 363253000424 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 363253000425 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 363253000426 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 363253000427 HD domain; Region: HD_3; pfam13023 363253000428 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 363253000429 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 363253000430 YtxH-like protein; Region: YtxH; cl02079 363253000431 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 363253000432 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 363253000433 Probable Catalytic site; other site 363253000434 metal-binding site 363253000435 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 363253000436 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 363253000437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 363253000438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253000439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253000440 S-adenosylmethionine binding site [chemical binding]; other site 363253000441 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 363253000442 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 363253000443 G1 box; other site 363253000444 putative GEF interaction site [polypeptide binding]; other site 363253000445 GTP/Mg2+ binding site [chemical binding]; other site 363253000446 Switch I region; other site 363253000447 G2 box; other site 363253000448 G3 box; other site 363253000449 Switch II region; other site 363253000450 G4 box; other site 363253000451 G5 box; other site 363253000452 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 363253000453 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 363253000454 GTP-binding protein YchF; Reviewed; Region: PRK09601 363253000455 YchF GTPase; Region: YchF; cd01900 363253000456 G1 box; other site 363253000457 GTP/Mg2+ binding site [chemical binding]; other site 363253000458 Switch I region; other site 363253000459 G2 box; other site 363253000460 Switch II region; other site 363253000461 G3 box; other site 363253000462 G4 box; other site 363253000463 G5 box; other site 363253000464 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 363253000465 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 363253000466 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 363253000467 Found in ATP-dependent protease La (LON); Region: LON; smart00464 363253000468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000469 Walker A motif; other site 363253000470 ATP binding site [chemical binding]; other site 363253000471 Walker B motif; other site 363253000472 arginine finger; other site 363253000473 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 363253000474 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 363253000475 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 363253000476 MPN+ (JAMM) motif; other site 363253000477 Zinc-binding site [ion binding]; other site 363253000478 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 363253000479 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 363253000480 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 363253000481 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 363253000482 HIGH motif; other site 363253000483 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 363253000484 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 363253000485 active site 363253000486 KMSKS motif; other site 363253000487 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 363253000488 tRNA binding surface [nucleotide binding]; other site 363253000489 transcription antitermination factor NusB; Region: nusB; TIGR01951 363253000490 putative RNA binding site [nucleotide binding]; other site 363253000491 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 363253000492 homopentamer interface [polypeptide binding]; other site 363253000493 active site 363253000494 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 363253000495 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 363253000496 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 363253000497 dimerization interface [polypeptide binding]; other site 363253000498 active site 363253000499 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 363253000500 Lumazine binding domain; Region: Lum_binding; pfam00677 363253000501 Lumazine binding domain; Region: Lum_binding; pfam00677 363253000502 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 363253000503 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 363253000504 catalytic motif [active] 363253000505 Zn binding site [ion binding]; other site 363253000506 RibD C-terminal domain; Region: RibD_C; cl17279 363253000507 deoxycytidylate deaminase 363253000508 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 363253000509 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 363253000510 dimer interface [polypeptide binding]; other site 363253000511 active site 363253000512 glycine-pyridoxal phosphate binding site [chemical binding]; other site 363253000513 folate binding site [chemical binding]; other site 363253000514 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 363253000515 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 363253000516 dimer interface [polypeptide binding]; other site 363253000517 active site 363253000518 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 363253000519 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 363253000520 NAD(P) binding site [chemical binding]; other site 363253000521 homotetramer interface [polypeptide binding]; other site 363253000522 homodimer interface [polypeptide binding]; other site 363253000523 active site 363253000524 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 363253000525 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 363253000526 dimer interface [polypeptide binding]; other site 363253000527 active site 363253000528 CoA binding pocket [chemical binding]; other site 363253000529 putative phosphate acyltransferase; Provisional; Region: PRK05331 363253000530 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 363253000531 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 363253000532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 363253000533 minor groove reading motif; other site 363253000534 helix-hairpin-helix signature motif; other site 363253000535 substrate binding pocket [chemical binding]; other site 363253000536 active site 363253000537 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 363253000538 active site 363253000539 8-oxo-dGMP binding site [chemical binding]; other site 363253000540 nudix motif; other site 363253000541 metal binding site [ion binding]; metal-binding site 363253000542 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 363253000543 substrate binding site [chemical binding]; other site 363253000544 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 363253000545 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 363253000546 substrate binding site [chemical binding]; other site 363253000547 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 363253000548 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 363253000549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 363253000550 ATP binding site [chemical binding]; other site 363253000551 putative Mg++ binding site [ion binding]; other site 363253000552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 363253000553 nucleotide binding region [chemical binding]; other site 363253000554 ATP-binding site [chemical binding]; other site 363253000555 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 363253000556 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 363253000557 peptide binding site [polypeptide binding]; other site 363253000558 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 363253000559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253000560 Zn2+ binding site [ion binding]; other site 363253000561 Mg2+ binding site [ion binding]; other site 363253000562 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 363253000563 synthetase active site [active] 363253000564 NTP binding site [chemical binding]; other site 363253000565 metal binding site [ion binding]; metal-binding site 363253000566 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 363253000567 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 363253000568 Protein of unknown function (DUF456); Region: DUF456; pfam04306 363253000569 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 363253000570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 363253000571 active site 363253000572 DNA binding site [nucleotide binding] 363253000573 Int/Topo IB signature motif; other site 363253000574 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 363253000575 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 363253000576 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 363253000577 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 363253000578 G1 box; other site 363253000579 putative GEF interaction site [polypeptide binding]; other site 363253000580 GTP/Mg2+ binding site [chemical binding]; other site 363253000581 Switch I region; other site 363253000582 G2 box; other site 363253000583 G3 box; other site 363253000584 Switch II region; other site 363253000585 G4 box; other site 363253000586 G5 box; other site 363253000587 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 363253000588 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 363253000589 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 363253000590 Endonuclease I; Region: Endonuclease_1; pfam04231 363253000591 ERF superfamily; Region: ERF; pfam04404 363253000592 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 363253000593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000594 Walker A motif; other site 363253000595 ATP binding site [chemical binding]; other site 363253000596 Walker B motif; other site 363253000597 arginine finger; other site 363253000598 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 363253000599 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 363253000600 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 363253000601 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 363253000602 metal ion-dependent adhesion site (MIDAS); other site 363253000603 FtsH Extracellular; Region: FtsH_ext; pfam06480 363253000604 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 363253000605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000606 Walker A motif; other site 363253000607 ATP binding site [chemical binding]; other site 363253000608 Walker B motif; other site 363253000609 arginine finger; other site 363253000610 Peptidase family M41; Region: Peptidase_M41; pfam01434 363253000611 dihydropteroate synthase; Region: DHPS; TIGR01496 363253000612 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 363253000613 substrate binding pocket [chemical binding]; other site 363253000614 dimer interface [polypeptide binding]; other site 363253000615 inhibitor binding site; inhibition site 363253000616 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 363253000617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 363253000618 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 363253000619 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 363253000620 active site 363253000621 substrate binding site [chemical binding]; other site 363253000622 metal binding site [ion binding]; metal-binding site 363253000623 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 363253000624 active site 363253000625 tetramer interface; other site 363253000626 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 363253000627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 363253000628 ATP binding site [chemical binding]; other site 363253000629 putative Mg++ binding site [ion binding]; other site 363253000630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 363253000631 ATP-binding site [chemical binding]; other site 363253000632 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 363253000633 Predicted permease [General function prediction only]; Region: COG2985 363253000634 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 363253000635 TrkA-C domain; Region: TrkA_C; pfam02080 363253000636 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 363253000637 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 363253000638 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 363253000639 membrane protein; Provisional; Region: PRK14397 363253000640 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 363253000641 RNB domain; Region: RNB; pfam00773 363253000642 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 363253000643 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 363253000644 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 363253000645 GDP-binding site [chemical binding]; other site 363253000646 ACT binding site; other site 363253000647 IMP binding site; other site 363253000648 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 363253000649 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 363253000650 Ligand Binding Site [chemical binding]; other site 363253000651 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 363253000652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253000653 FeS/SAM binding site; other site 363253000654 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 363253000655 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 363253000656 dimer interface [polypeptide binding]; other site 363253000657 active site 363253000658 Schiff base residues; other site 363253000659 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 363253000660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253000661 FeS/SAM binding site; other site 363253000662 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 363253000663 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 363253000664 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 363253000665 Flagellar protein FliS; Region: FliS; cl00654 363253000666 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 363253000667 flagellar capping protein; Provisional; Region: PRK12765 363253000668 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 363253000669 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 363253000670 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 363253000671 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 363253000672 active site 363253000673 dimer interface [polypeptide binding]; other site 363253000674 motif 1; other site 363253000675 motif 2; other site 363253000676 motif 3; other site 363253000677 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 363253000678 anticodon binding site; other site 363253000679 translation initiation factor IF-3; Region: infC; TIGR00168 363253000680 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 363253000681 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 363253000682 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 363253000683 23S rRNA binding site [nucleotide binding]; other site 363253000684 L21 binding site [polypeptide binding]; other site 363253000685 L13 binding site [polypeptide binding]; other site 363253000686 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 363253000687 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 363253000688 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 363253000689 dimer interface [polypeptide binding]; other site 363253000690 motif 1; other site 363253000691 active site 363253000692 motif 2; other site 363253000693 motif 3; other site 363253000694 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 363253000695 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 363253000696 putative tRNA-binding site [nucleotide binding]; other site 363253000697 B3/4 domain; Region: B3_4; pfam03483 363253000698 tRNA synthetase B5 domain; Region: B5; smart00874 363253000699 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 363253000700 dimer interface [polypeptide binding]; other site 363253000701 motif 1; other site 363253000702 motif 3; other site 363253000703 motif 2; other site 363253000704 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 363253000705 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 363253000706 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 363253000707 DNA binding residues [nucleotide binding] 363253000708 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 363253000709 substrate binding site [chemical binding]; other site 363253000710 hexamer interface [polypeptide binding]; other site 363253000711 transketolase; Reviewed; Region: PRK12753 363253000712 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 363253000713 TPP-binding site [chemical binding]; other site 363253000714 dimer interface [polypeptide binding]; other site 363253000715 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 363253000716 PYR/PP interface [polypeptide binding]; other site 363253000717 dimer interface [polypeptide binding]; other site 363253000718 TPP binding site [chemical binding]; other site 363253000719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 363253000720 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 363253000721 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 363253000722 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 363253000723 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 363253000724 RNA/DNA hybrid binding site [nucleotide binding]; other site 363253000725 active site 363253000726 hypothetical protein; Provisional; Region: PRK14680 363253000727 Predicted methyltransferases [General function prediction only]; Region: COG0313 363253000728 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 363253000729 putative SAM binding site [chemical binding]; other site 363253000730 putative homodimer interface [polypeptide binding]; other site 363253000731 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 363253000732 SmpB-tmRNA interface; other site 363253000733 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 363253000734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253000735 Walker A/P-loop; other site 363253000736 ATP binding site [chemical binding]; other site 363253000737 Q-loop/lid; other site 363253000738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 363253000739 ABC transporter; Region: ABC_tran_2; pfam12848 363253000740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 363253000741 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 363253000742 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 363253000743 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 363253000744 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 363253000745 putative active site [active] 363253000746 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 363253000747 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 363253000748 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 363253000749 active site 363253000750 HIGH motif; other site 363253000751 KMSK motif region; other site 363253000752 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 363253000753 tRNA binding surface [nucleotide binding]; other site 363253000754 anticodon binding site; other site 363253000755 Sporulation related domain; Region: SPOR; pfam05036 363253000756 Permease; Region: Permease; pfam02405 363253000757 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 363253000758 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 363253000759 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 363253000760 Walker A/P-loop; other site 363253000761 ATP binding site [chemical binding]; other site 363253000762 Q-loop/lid; other site 363253000763 ABC transporter signature motif; other site 363253000764 Walker B; other site 363253000765 D-loop; other site 363253000766 H-loop/switch region; other site 363253000767 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 363253000768 mce related protein; Region: MCE; pfam02470 363253000769 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 363253000770 VacJ like lipoprotein; Region: VacJ; cl01073 363253000771 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 363253000772 MutS domain I; Region: MutS_I; pfam01624 363253000773 MutS domain II; Region: MutS_II; pfam05188 363253000774 MutS domain III; Region: MutS_III; pfam05192 363253000775 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 363253000776 Walker A/P-loop; other site 363253000777 ATP binding site [chemical binding]; other site 363253000778 Q-loop/lid; other site 363253000779 ABC transporter signature motif; other site 363253000780 Walker B; other site 363253000781 D-loop; other site 363253000782 H-loop/switch region; other site 363253000783 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 363253000784 nucleotide binding site/active site [active] 363253000785 HIT family signature motif; other site 363253000786 catalytic residue [active] 363253000787 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 363253000788 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 363253000789 active site 363253000790 NTP binding site [chemical binding]; other site 363253000791 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 363253000792 metal binding triad [ion binding]; metal-binding site 363253000793 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 363253000794 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 363253000795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 363253000796 active site 363253000797 DNA binding site [nucleotide binding] 363253000798 Int/Topo IB signature motif; other site 363253000799 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 363253000800 catalytic center binding site [active] 363253000801 ATP binding site [chemical binding]; other site 363253000802 excinuclease ABC subunit B; Provisional; Region: PRK05298 363253000803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 363253000804 ATP binding site [chemical binding]; other site 363253000805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 363253000806 nucleotide binding region [chemical binding]; other site 363253000807 ATP-binding site [chemical binding]; other site 363253000808 Ultra-violet resistance protein B; Region: UvrB; pfam12344 363253000809 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 363253000810 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 363253000811 nucleotide binding pocket [chemical binding]; other site 363253000812 K-X-D-G motif; other site 363253000813 catalytic site [active] 363253000814 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 363253000815 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 363253000816 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 363253000817 Dimer interface [polypeptide binding]; other site 363253000818 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 363253000819 dihydrodipicolinate reductase; Provisional; Region: PRK00048 363253000820 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 363253000821 NAD synthetase; Provisional; Region: PRK13981 363253000822 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 363253000823 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 363253000824 homodimer interface [polypeptide binding]; other site 363253000825 NAD binding pocket [chemical binding]; other site 363253000826 ATP binding pocket [chemical binding]; other site 363253000827 Mg binding site [ion binding]; other site 363253000828 active-site loop [active] 363253000829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 363253000830 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 363253000831 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 363253000832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253000833 TPR motif; other site 363253000834 Tetratricopeptide repeat; Region: TPR_16; pfam13432 363253000835 binding surface 363253000836 AMIN domain; Region: AMIN; pfam11741 363253000837 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 363253000838 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 363253000839 Walker A/P-loop; other site 363253000840 ATP binding site [chemical binding]; other site 363253000841 Q-loop/lid; other site 363253000842 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 363253000843 ABC transporter signature motif; other site 363253000844 Walker B; other site 363253000845 D-loop; other site 363253000846 H-loop/switch region; other site 363253000847 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 363253000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000849 dimer interface [polypeptide binding]; other site 363253000850 conserved gate region; other site 363253000851 putative PBP binding loops; other site 363253000852 ABC-ATPase subunit interface; other site 363253000853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 363253000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253000855 dimer interface [polypeptide binding]; other site 363253000856 conserved gate region; other site 363253000857 putative PBP binding loops; other site 363253000858 ABC-ATPase subunit interface; other site 363253000859 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 363253000860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253000861 Zn2+ binding site [ion binding]; other site 363253000862 Mg2+ binding site [ion binding]; other site 363253000863 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 363253000864 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 363253000865 active site 363253000866 PHP Thumb interface [polypeptide binding]; other site 363253000867 metal binding site [ion binding]; metal-binding site 363253000868 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 363253000869 generic binding surface I; other site 363253000870 generic binding surface II; other site 363253000871 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 363253000872 active site 363253000873 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 363253000874 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 363253000875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 363253000876 dimerization interface [polypeptide binding]; other site 363253000877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 363253000878 putative active site [active] 363253000879 heme pocket [chemical binding]; other site 363253000880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 363253000881 dimer interface [polypeptide binding]; other site 363253000882 phosphorylation site [posttranslational modification] 363253000883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253000884 ATP binding site [chemical binding]; other site 363253000885 Mg2+ binding site [ion binding]; other site 363253000886 G-X-G motif; other site 363253000887 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 363253000888 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 363253000889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253000890 catalytic residue [active] 363253000891 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 363253000892 amino acid transporter; Region: 2A0306; TIGR00909 363253000893 transcription termination factor Rho; Provisional; Region: rho; PRK09376 363253000894 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 363253000895 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 363253000896 RNA binding site [nucleotide binding]; other site 363253000897 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 363253000898 multimer interface [polypeptide binding]; other site 363253000899 Walker A motif; other site 363253000900 ATP binding site [chemical binding]; other site 363253000901 Walker B motif; other site 363253000902 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 363253000903 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 363253000904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 363253000905 catalytic residue [active] 363253000906 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 363253000907 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 363253000908 trimerization site [polypeptide binding]; other site 363253000909 active site 363253000910 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 363253000911 NifU-like domain; Region: NifU; cl00484 363253000912 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 363253000913 active site 363253000914 putative DNA-binding cleft [nucleotide binding]; other site 363253000915 dimer interface [polypeptide binding]; other site 363253000916 hypothetical protein; Validated; Region: PRK00110 363253000917 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 363253000918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253000919 S-adenosylmethionine binding site [chemical binding]; other site 363253000920 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 363253000921 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 363253000922 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 363253000923 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 363253000924 non-heme iron binding site [ion binding]; other site 363253000925 dimer interface [polypeptide binding]; other site 363253000926 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 363253000927 non-heme iron binding site [ion binding]; other site 363253000928 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 363253000929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 363253000930 Flavodoxin; Region: Flavodoxin_1; pfam00258 363253000931 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 363253000932 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 363253000933 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 363253000934 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 363253000935 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 363253000936 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 363253000937 dimer interface [polypeptide binding]; other site 363253000938 PYR/PP interface [polypeptide binding]; other site 363253000939 TPP binding site [chemical binding]; other site 363253000940 substrate binding site [chemical binding]; other site 363253000941 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 363253000942 Domain of unknown function; Region: EKR; smart00890 363253000943 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 363253000944 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 363253000945 TPP-binding site [chemical binding]; other site 363253000946 dimer interface [polypeptide binding]; other site 363253000947 phosphate acetyltransferase; Reviewed; Region: PRK05632 363253000948 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 363253000949 DRTGG domain; Region: DRTGG; pfam07085 363253000950 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 363253000951 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 363253000952 propionate/acetate kinase; Provisional; Region: PRK12379 363253000953 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 363253000954 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 363253000955 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 363253000956 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 363253000957 active site 363253000958 (T/H)XGH motif; other site 363253000959 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 363253000960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253000961 S-adenosylmethionine binding site [chemical binding]; other site 363253000962 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 363253000963 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 363253000964 Beta-Casp domain; Region: Beta-Casp; smart01027 363253000965 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 363253000966 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 363253000967 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 363253000968 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 363253000969 NlpC/P60 family; Region: NLPC_P60; cl17555 363253000970 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 363253000971 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 363253000972 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 363253000973 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 363253000974 NlpC/P60 family; Region: NLPC_P60; cl17555 363253000975 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 363253000976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253000977 Walker A motif; other site 363253000978 ATP binding site [chemical binding]; other site 363253000979 Walker B motif; other site 363253000980 Family description; Region: UvrD_C_2; pfam13538 363253000981 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 363253000982 active site 363253000983 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 363253000984 Pirin-related protein [General function prediction only]; Region: COG1741 363253000985 Pirin; Region: Pirin; pfam02678 363253000986 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 363253000987 hypothetical protein; Provisional; Region: PRK07208 363253000988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 363253000989 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 363253000990 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 363253000991 Fumarase C-terminus; Region: Fumerase_C; cl00795 363253000992 fumarate hydratase; Provisional; Region: PRK06246 363253000993 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 363253000994 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 363253000995 dimerization interface [polypeptide binding]; other site 363253000996 putative ATP binding site [chemical binding]; other site 363253000997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 363253000998 Smr domain; Region: Smr; pfam01713 363253000999 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 363253001000 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 363253001001 dimer interface [polypeptide binding]; other site 363253001002 motif 1; other site 363253001003 active site 363253001004 motif 2; other site 363253001005 motif 3; other site 363253001006 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 363253001007 Recombination protein O N terminal; Region: RecO_N; pfam11967 363253001008 Recombination protein O C terminal; Region: RecO_C; pfam02565 363253001009 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 363253001010 Helix-turn-helix domain; Region: HTH_25; pfam13413 363253001011 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 363253001012 SurA N-terminal domain; Region: SurA_N_3; cl07813 363253001013 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 363253001014 SurA N-terminal domain; Region: SurA_N_3; cl07813 363253001015 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 363253001016 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 363253001017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 363253001018 ATP binding site [chemical binding]; other site 363253001019 putative Mg++ binding site [ion binding]; other site 363253001020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 363253001021 nucleotide binding region [chemical binding]; other site 363253001022 ATP-binding site [chemical binding]; other site 363253001023 TRCF domain; Region: TRCF; pfam03461 363253001024 Predicted integral membrane protein [Function unknown]; Region: COG0392 363253001025 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 363253001026 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 363253001027 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 363253001028 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 363253001029 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 363253001030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253001031 FeS/SAM binding site; other site 363253001032 hypothetical protein; Provisional; Region: PRK11820 363253001033 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 363253001034 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 363253001035 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 363253001036 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 363253001037 catalytic site [active] 363253001038 G-X2-G-X-G-K; other site 363253001039 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 363253001040 active site 363253001041 dimer interface [polypeptide binding]; other site 363253001042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 363253001043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001044 binding surface 363253001045 TPR motif; other site 363253001046 TPR repeat; Region: TPR_11; pfam13414 363253001047 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 363253001048 DHH family; Region: DHH; pfam01368 363253001049 DHHA1 domain; Region: DHHA1; pfam02272 363253001050 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 363253001051 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 363253001052 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 363253001053 active site 363253001054 CoA binding domain; Region: CoA_binding; cl17356 363253001055 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 363253001056 HSP70 interaction site [polypeptide binding]; other site 363253001057 adenylate kinase; Provisional; Region: PRK14529 363253001058 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 363253001059 AMP-binding site [chemical binding]; other site 363253001060 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 363253001061 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 363253001062 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 363253001063 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253001064 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253001065 putative active site [active] 363253001066 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 363253001067 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 363253001068 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 363253001069 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 363253001070 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 363253001071 tRNA; other site 363253001072 putative tRNA binding site [nucleotide binding]; other site 363253001073 putative NADP binding site [chemical binding]; other site 363253001074 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 363253001075 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 363253001076 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 363253001077 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 363253001078 P loop; other site 363253001079 GTP binding site [chemical binding]; other site 363253001080 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 363253001081 thiamine phosphate binding site [chemical binding]; other site 363253001082 active site 363253001083 pyrophosphate binding site [ion binding]; other site 363253001084 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 363253001085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 363253001086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 363253001087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001088 S-adenosylmethionine binding site [chemical binding]; other site 363253001089 Protein of unknown function (DUF721); Region: DUF721; pfam05258 363253001090 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 363253001091 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 363253001092 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 363253001093 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 363253001094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 363253001095 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253001096 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 363253001097 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 363253001098 putative active site [active] 363253001099 catalytic site [active] 363253001100 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 363253001101 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 363253001102 putative homodimer interface [polypeptide binding]; other site 363253001103 putative active site pocket [active] 363253001104 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 363253001105 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 363253001106 feedback inhibition sensing region; other site 363253001107 homohexameric interface [polypeptide binding]; other site 363253001108 nucleotide binding site [chemical binding]; other site 363253001109 N-acetyl-L-glutamate binding site [chemical binding]; other site 363253001110 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 363253001111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253001112 Walker A motif; other site 363253001113 ATP binding site [chemical binding]; other site 363253001114 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 363253001115 Walker B motif; other site 363253001116 arginine finger; other site 363253001117 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 363253001118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 363253001119 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 363253001120 Walker A/P-loop; other site 363253001121 ATP binding site [chemical binding]; other site 363253001122 Q-loop/lid; other site 363253001123 ABC transporter signature motif; other site 363253001124 Walker B; other site 363253001125 D-loop; other site 363253001126 H-loop/switch region; other site 363253001127 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 363253001128 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 363253001129 Walker A/P-loop; other site 363253001130 ATP binding site [chemical binding]; other site 363253001131 Q-loop/lid; other site 363253001132 ABC transporter signature motif; other site 363253001133 Walker B; other site 363253001134 D-loop; other site 363253001135 H-loop/switch region; other site 363253001136 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 363253001137 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 363253001138 TM-ABC transporter signature motif; other site 363253001139 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 363253001140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 363253001141 TM-ABC transporter signature motif; other site 363253001142 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 363253001143 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 363253001144 dimerization interface [polypeptide binding]; other site 363253001145 ligand binding site [chemical binding]; other site 363253001146 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 363253001147 Yip1 domain; Region: Yip1; pfam04893 363253001148 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 363253001149 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 363253001150 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 363253001151 nucleoside/Zn binding site; other site 363253001152 dimer interface [polypeptide binding]; other site 363253001153 catalytic motif [active] 363253001154 Methyltransferase domain; Region: Methyltransf_31; pfam13847 363253001155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001156 S-adenosylmethionine binding site [chemical binding]; other site 363253001157 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 363253001158 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 363253001159 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 363253001160 protein binding site [polypeptide binding]; other site 363253001161 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 363253001162 protein binding site [polypeptide binding]; other site 363253001163 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 363253001164 Transglycosylase; Region: Transgly; pfam00912 363253001165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 363253001166 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 363253001167 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 363253001168 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 363253001169 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 363253001170 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 363253001171 ATP binding site [chemical binding]; other site 363253001172 active site 363253001173 substrate binding site [chemical binding]; other site 363253001174 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 363253001175 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 363253001176 NAD binding site [chemical binding]; other site 363253001177 homotetramer interface [polypeptide binding]; other site 363253001178 homodimer interface [polypeptide binding]; other site 363253001179 substrate binding site [chemical binding]; other site 363253001180 active site 363253001181 Malic enzyme, N-terminal domain; Region: malic; pfam00390 363253001182 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 363253001183 putative NAD(P) binding site [chemical binding]; other site 363253001184 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 363253001185 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 363253001186 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 363253001187 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 363253001188 replicative DNA helicase; Region: DnaB; TIGR00665 363253001189 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 363253001190 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 363253001191 Walker A motif; other site 363253001192 ATP binding site [chemical binding]; other site 363253001193 Walker B motif; other site 363253001194 DNA binding loops [nucleotide binding] 363253001195 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 363253001196 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 363253001197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 363253001198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253001199 Walker A/P-loop; other site 363253001200 ATP binding site [chemical binding]; other site 363253001201 Q-loop/lid; other site 363253001202 ABC transporter signature motif; other site 363253001203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 363253001204 Walker B; other site 363253001205 D-loop; other site 363253001206 ABC transporter; Region: ABC_tran_2; pfam12848 363253001207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 363253001208 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 363253001209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001210 S-adenosylmethionine binding site [chemical binding]; other site 363253001211 AsmA family; Region: AsmA; pfam05170 363253001212 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 363253001213 MgtE intracellular N domain; Region: MgtE_N; pfam03448 363253001214 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 363253001215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 363253001216 Divalent cation transporter; Region: MgtE; pfam01769 363253001217 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 363253001218 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 363253001219 dimerization interface [polypeptide binding]; other site 363253001220 active site 363253001221 quinolinate synthetase; Provisional; Region: PRK09375 363253001222 L-aspartate oxidase; Region: nadB; TIGR00551 363253001223 L-aspartate oxidase; Provisional; Region: PRK06175 363253001224 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 363253001225 YGGT family; Region: YGGT; pfam02325 363253001226 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 363253001227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 363253001228 motif II; other site 363253001229 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 363253001230 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 363253001231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 363253001232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 363253001233 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 363253001234 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 363253001235 catalytic residues [active] 363253001236 UGMP family protein; Validated; Region: PRK09604 363253001237 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 363253001238 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 363253001239 AMP binding site [chemical binding]; other site 363253001240 metal binding site [ion binding]; metal-binding site 363253001241 active site 363253001242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 363253001243 TPR motif; other site 363253001244 binding surface 363253001245 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 363253001246 Septum formation initiator; Region: DivIC; pfam04977 363253001247 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 363253001248 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 363253001249 Walker A motif; other site 363253001250 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 363253001251 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 363253001252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001253 S-adenosylmethionine binding site [chemical binding]; other site 363253001254 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 363253001255 Peptidase family M23; Region: Peptidase_M23; pfam01551 363253001256 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 363253001257 rRNA interaction site [nucleotide binding]; other site 363253001258 S8 interaction site; other site 363253001259 putative laminin-1 binding site; other site 363253001260 elongation factor Ts; Provisional; Region: tsf; PRK09377 363253001261 UBA/TS-N domain; Region: UBA; pfam00627 363253001262 Elongation factor TS; Region: EF_TS; pfam00889 363253001263 Elongation factor TS; Region: EF_TS; pfam00889 363253001264 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 363253001265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 363253001266 NAD(P) binding site [chemical binding]; other site 363253001267 active site 363253001268 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 363253001269 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 363253001270 inhibitor-cofactor binding pocket; inhibition site 363253001271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253001272 catalytic residue [active] 363253001273 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 363253001274 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 363253001275 putative metal binding site; other site 363253001276 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 363253001277 putative nucleotide binding site [chemical binding]; other site 363253001278 uridine monophosphate binding site [chemical binding]; other site 363253001279 homohexameric interface [polypeptide binding]; other site 363253001280 ribosome recycling factor; Reviewed; Region: frr; PRK00083 363253001281 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 363253001282 hinge region; other site 363253001283 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 363253001284 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 363253001285 catalytic residue [active] 363253001286 putative FPP diphosphate binding site; other site 363253001287 putative FPP binding hydrophobic cleft; other site 363253001288 dimer interface [polypeptide binding]; other site 363253001289 putative IPP diphosphate binding site; other site 363253001290 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 363253001291 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 363253001292 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 363253001293 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 363253001294 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 363253001295 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 363253001296 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 363253001297 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 363253001298 active site 363253001299 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 363253001300 protein binding site [polypeptide binding]; other site 363253001301 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 363253001302 putative substrate binding region [chemical binding]; other site 363253001303 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 363253001304 Glycoprotease family; Region: Peptidase_M22; pfam00814 363253001305 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 363253001306 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 363253001307 DNA binding site [nucleotide binding] 363253001308 substrate interaction site [chemical binding]; other site 363253001309 prolyl-tRNA synthetase; Provisional; Region: PRK09194 363253001310 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 363253001311 dimer interface [polypeptide binding]; other site 363253001312 motif 1; other site 363253001313 active site 363253001314 motif 2; other site 363253001315 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 363253001316 putative deacylase active site [active] 363253001317 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 363253001318 active site 363253001319 motif 3; other site 363253001320 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 363253001321 anticodon binding site; other site 363253001322 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 363253001323 rod shape-determining protein MreB; Provisional; Region: PRK13927 363253001324 MreB and similar proteins; Region: MreB_like; cd10225 363253001325 nucleotide binding site [chemical binding]; other site 363253001326 Mg binding site [ion binding]; other site 363253001327 putative protofilament interaction site [polypeptide binding]; other site 363253001328 RodZ interaction site [polypeptide binding]; other site 363253001329 rod shape-determining protein MreC; Provisional; Region: PRK13922 363253001330 rod shape-determining protein MreC; Region: MreC; pfam04085 363253001331 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 363253001332 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 363253001333 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 363253001334 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 363253001335 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 363253001336 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 363253001337 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 363253001338 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 363253001339 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 363253001340 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 363253001341 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 363253001342 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 363253001343 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 363253001344 beta subunit interaction interface [polypeptide binding]; other site 363253001345 Walker A motif; other site 363253001346 ATP binding site [chemical binding]; other site 363253001347 Walker B motif; other site 363253001348 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 363253001349 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 363253001350 core domain interface [polypeptide binding]; other site 363253001351 delta subunit interface [polypeptide binding]; other site 363253001352 epsilon subunit interface [polypeptide binding]; other site 363253001353 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 363253001354 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 363253001355 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 363253001356 alpha subunit interaction interface [polypeptide binding]; other site 363253001357 Walker A motif; other site 363253001358 ATP binding site [chemical binding]; other site 363253001359 Walker B motif; other site 363253001360 inhibitor binding site; inhibition site 363253001361 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 363253001362 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 363253001363 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 363253001364 gamma subunit interface [polypeptide binding]; other site 363253001365 epsilon subunit interface [polypeptide binding]; other site 363253001366 LBP interface [polypeptide binding]; other site 363253001367 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 363253001368 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 363253001369 generic binding surface II; other site 363253001370 generic binding surface I; other site 363253001371 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 363253001372 Peptidase family M23; Region: Peptidase_M23; pfam01551 363253001373 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 363253001374 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 363253001375 substrate binding pocket [chemical binding]; other site 363253001376 chain length determination region; other site 363253001377 substrate-Mg2+ binding site; other site 363253001378 catalytic residues [active] 363253001379 aspartate-rich region 1; other site 363253001380 active site lid residues [active] 363253001381 aspartate-rich region 2; other site 363253001382 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 363253001383 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 363253001384 TPP-binding site; other site 363253001385 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 363253001386 PYR/PP interface [polypeptide binding]; other site 363253001387 dimer interface [polypeptide binding]; other site 363253001388 TPP binding site [chemical binding]; other site 363253001389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 363253001390 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 363253001391 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 363253001392 Ligand Binding Site [chemical binding]; other site 363253001393 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 363253001394 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 363253001395 substrate binding site [chemical binding]; other site 363253001396 active site 363253001397 catalytic residues [active] 363253001398 heterodimer interface [polypeptide binding]; other site 363253001399 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 363253001400 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 363253001401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253001402 catalytic residue [active] 363253001403 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 363253001404 active site 363253001405 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 363253001406 active site 363253001407 ribulose/triose binding site [chemical binding]; other site 363253001408 phosphate binding site [ion binding]; other site 363253001409 substrate (anthranilate) binding pocket [chemical binding]; other site 363253001410 product (indole) binding pocket [chemical binding]; other site 363253001411 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 363253001412 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 363253001413 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 363253001414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 363253001415 kynureninase; Region: kynureninase; TIGR01814 363253001416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 363253001417 catalytic residue [active] 363253001418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 363253001419 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 363253001420 TM-ABC transporter signature motif; other site 363253001421 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 363253001422 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 363253001423 Walker A/P-loop; other site 363253001424 ATP binding site [chemical binding]; other site 363253001425 Q-loop/lid; other site 363253001426 ABC transporter signature motif; other site 363253001427 Walker B; other site 363253001428 D-loop; other site 363253001429 H-loop/switch region; other site 363253001430 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 363253001431 zinc binding site [ion binding]; other site 363253001432 putative ligand binding site [chemical binding]; other site 363253001433 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 363253001434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 363253001435 NAD(P) binding site [chemical binding]; other site 363253001436 active site 363253001437 biotin synthase; Region: bioB; TIGR00433 363253001438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253001439 FeS/SAM binding site; other site 363253001440 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 363253001441 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 363253001442 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 363253001443 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 363253001444 catalytic residue [active] 363253001445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 363253001446 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 363253001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001448 S-adenosylmethionine binding site [chemical binding]; other site 363253001449 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 363253001450 AAA domain; Region: AAA_26; pfam13500 363253001451 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 363253001452 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 363253001453 inhibitor-cofactor binding pocket; inhibition site 363253001454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253001455 catalytic residue [active] 363253001456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 363253001457 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 363253001458 Na2 binding site [ion binding]; other site 363253001459 putative substrate binding site 1 [chemical binding]; other site 363253001460 Na binding site 1 [ion binding]; other site 363253001461 putative substrate binding site 2 [chemical binding]; other site 363253001462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253001463 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 363253001464 FeS/SAM binding site; other site 363253001465 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 363253001466 HIT family signature motif; other site 363253001467 catalytic residue [active] 363253001468 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 363253001469 IHF - DNA interface [nucleotide binding]; other site 363253001470 IHF dimer interface [polypeptide binding]; other site 363253001471 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 363253001472 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 363253001473 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 363253001474 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 363253001475 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 363253001476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253001477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253001478 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 363253001479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 363253001480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253001481 homodimer interface [polypeptide binding]; other site 363253001482 catalytic residue [active] 363253001483 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 363253001484 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 363253001485 catalytic core [active] 363253001486 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 363253001487 catalytic core [active] 363253001488 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 363253001489 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 363253001490 hydrogenase 1 large subunit; Provisional; Region: PRK10170 363253001491 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 363253001492 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 363253001493 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 363253001494 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 363253001495 putative substrate-binding site; other site 363253001496 nickel binding site [ion binding]; other site 363253001497 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253001498 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 363253001499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253001500 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 363253001501 putative active site [active] 363253001502 dimerization interface [polypeptide binding]; other site 363253001503 putative tRNAtyr binding site [nucleotide binding]; other site 363253001504 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 363253001505 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 363253001506 substrate binding site; other site 363253001507 dimer interface; other site 363253001508 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 363253001509 homotrimer interaction site [polypeptide binding]; other site 363253001510 zinc binding site [ion binding]; other site 363253001511 CDP-binding sites; other site 363253001512 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 363253001513 Putative zinc ribbon domain; Region: DUF164; pfam02591 363253001514 Uncharacterized conserved protein [Function unknown]; Region: COG0327 363253001515 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 363253001516 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 363253001517 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 363253001518 conserved cys residue [active] 363253001519 CTP synthetase; Validated; Region: pyrG; PRK05380 363253001520 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 363253001521 Catalytic site [active] 363253001522 active site 363253001523 UTP binding site [chemical binding]; other site 363253001524 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 363253001525 active site 363253001526 putative oxyanion hole; other site 363253001527 catalytic triad [active] 363253001528 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 363253001529 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 363253001530 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 363253001531 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 363253001532 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 363253001533 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 363253001534 OstA-like protein; Region: OstA; pfam03968 363253001535 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 363253001536 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 363253001537 Walker A/P-loop; other site 363253001538 ATP binding site [chemical binding]; other site 363253001539 Q-loop/lid; other site 363253001540 ABC transporter signature motif; other site 363253001541 Walker B; other site 363253001542 D-loop; other site 363253001543 H-loop/switch region; other site 363253001544 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 363253001545 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 363253001546 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 363253001547 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 363253001548 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 363253001549 30S subunit binding site; other site 363253001550 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 363253001551 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 363253001552 substrate binding site [chemical binding]; other site 363253001553 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 363253001554 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 363253001555 HIGH motif; other site 363253001556 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 363253001557 active site 363253001558 KMSKS motif; other site 363253001559 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 363253001560 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 363253001561 Phosphoglycerate kinase; Region: PGK; pfam00162 363253001562 substrate binding site [chemical binding]; other site 363253001563 hinge regions; other site 363253001564 ADP binding site [chemical binding]; other site 363253001565 catalytic site [active] 363253001566 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 363253001567 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 363253001568 NAD binding site [chemical binding]; other site 363253001569 homodimer interface [polypeptide binding]; other site 363253001570 active site 363253001571 substrate binding site [chemical binding]; other site 363253001572 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 363253001573 active site clefts [active] 363253001574 zinc binding site [ion binding]; other site 363253001575 dimer interface [polypeptide binding]; other site 363253001576 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 363253001577 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 363253001578 Walker A/P-loop; other site 363253001579 ATP binding site [chemical binding]; other site 363253001580 Q-loop/lid; other site 363253001581 ABC transporter signature motif; other site 363253001582 Walker B; other site 363253001583 D-loop; other site 363253001584 H-loop/switch region; other site 363253001585 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 363253001586 putative carbohydrate binding site [chemical binding]; other site 363253001587 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253001588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001589 S-adenosylmethionine binding site [chemical binding]; other site 363253001590 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 363253001591 Peptidase family M23; Region: Peptidase_M23; pfam01551 363253001592 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 363253001593 putative active site [active] 363253001594 putative metal binding site [ion binding]; other site 363253001595 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 363253001596 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 363253001597 Methyltransferase domain; Region: Methyltransf_26; pfam13659 363253001598 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 363253001599 gating phenylalanine in ion channel; other site 363253001600 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 363253001601 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 363253001602 ATP cone domain; Region: ATP-cone; pfam03477 363253001603 Class I ribonucleotide reductase; Region: RNR_I; cd01679 363253001604 active site 363253001605 dimer interface [polypeptide binding]; other site 363253001606 catalytic residues [active] 363253001607 effector binding site; other site 363253001608 R2 peptide binding site; other site 363253001609 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 363253001610 dimer interface [polypeptide binding]; other site 363253001611 putative radical transfer pathway; other site 363253001612 diiron center [ion binding]; other site 363253001613 tyrosyl radical; other site 363253001614 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 363253001615 Amidohydrolase; Region: Amidohydro_4; pfam13147 363253001616 active site 363253001617 putative substrate binding pocket [chemical binding]; other site 363253001618 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 363253001619 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 363253001620 active site 363253001621 catalytic triad [active] 363253001622 oxyanion hole [active] 363253001623 Predicted esterase [General function prediction only]; Region: COG0627 363253001624 S-formylglutathione hydrolase; Region: PLN02442 363253001625 Uncharacterized conserved protein [Function unknown]; Region: COG1433 363253001626 flagellar motor protein MotA; Validated; Region: PRK09110 363253001627 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 363253001628 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 363253001629 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 363253001630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 363253001631 ligand binding site [chemical binding]; other site 363253001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253001633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 363253001634 putative substrate translocation pore; other site 363253001635 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 363253001636 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 363253001637 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 363253001638 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 363253001639 ligand binding site [chemical binding]; other site 363253001640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 363253001641 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 363253001642 ATP-grasp domain; Region: ATP-grasp_4; cl17255 363253001643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 363253001644 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 363253001645 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 363253001646 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 363253001647 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 363253001648 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 363253001649 dimer interface [polypeptide binding]; other site 363253001650 ssDNA binding site [nucleotide binding]; other site 363253001651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 363253001652 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 363253001653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 363253001654 active site 363253001655 HIGH motif; other site 363253001656 nucleotide binding site [chemical binding]; other site 363253001657 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 363253001658 KMSKS motif; other site 363253001659 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 363253001660 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 363253001661 EF-hand domain pair; Region: EF_hand_5; pfam13499 363253001662 Ca2+ binding site [ion binding]; other site 363253001663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253001664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253001665 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 363253001666 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 363253001667 putative ligand binding site [chemical binding]; other site 363253001668 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 363253001669 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 363253001670 TM-ABC transporter signature motif; other site 363253001671 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 363253001672 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 363253001673 TM-ABC transporter signature motif; other site 363253001674 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 363253001675 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 363253001676 Walker A/P-loop; other site 363253001677 ATP binding site [chemical binding]; other site 363253001678 Q-loop/lid; other site 363253001679 ABC transporter signature motif; other site 363253001680 Walker B; other site 363253001681 D-loop; other site 363253001682 H-loop/switch region; other site 363253001683 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 363253001684 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 363253001685 Walker A/P-loop; other site 363253001686 ATP binding site [chemical binding]; other site 363253001687 Q-loop/lid; other site 363253001688 ABC transporter signature motif; other site 363253001689 Walker B; other site 363253001690 D-loop; other site 363253001691 H-loop/switch region; other site 363253001692 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 363253001693 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 363253001694 YceG-like family; Region: YceG; pfam02618 363253001695 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 363253001696 dimerization interface [polypeptide binding]; other site 363253001697 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 363253001698 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 363253001699 ThiS interaction site; other site 363253001700 putative active site [active] 363253001701 tetramer interface [polypeptide binding]; other site 363253001702 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 363253001703 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 363253001704 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 363253001705 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 363253001706 ATP binding site [chemical binding]; other site 363253001707 substrate interface [chemical binding]; other site 363253001708 multidrug efflux protein; Reviewed; Region: PRK01766 363253001709 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 363253001710 cation binding site [ion binding]; other site 363253001711 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 363253001712 Carbon starvation protein CstA; Region: CstA; pfam02554 363253001713 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 363253001714 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 363253001715 EVE domain; Region: EVE; cl00728 363253001716 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 363253001717 Bacterial sugar transferase; Region: Bac_transf; pfam02397 363253001718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253001719 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 363253001720 putative ADP-binding pocket [chemical binding]; other site 363253001721 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 363253001722 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 363253001723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 363253001724 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 363253001725 substrate binding pocket [chemical binding]; other site 363253001726 chain length determination region; other site 363253001727 substrate-Mg2+ binding site; other site 363253001728 catalytic residues [active] 363253001729 aspartate-rich region 1; other site 363253001730 active site lid residues [active] 363253001731 aspartate-rich region 2; other site 363253001732 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 363253001733 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 363253001734 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 363253001735 dimerization interface [polypeptide binding]; other site 363253001736 ATP binding site [chemical binding]; other site 363253001737 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 363253001738 dimerization interface [polypeptide binding]; other site 363253001739 ATP binding site [chemical binding]; other site 363253001740 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 363253001741 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 363253001742 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 363253001743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 363253001744 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 363253001745 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 363253001746 DNA binding residues [nucleotide binding] 363253001747 DNA primase, catalytic core; Region: dnaG; TIGR01391 363253001748 CHC2 zinc finger; Region: zf-CHC2; cl17510 363253001749 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 363253001750 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 363253001751 active site 363253001752 metal binding site [ion binding]; metal-binding site 363253001753 interdomain interaction site; other site 363253001754 Yqey-like protein; Region: YqeY; pfam09424 363253001755 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 363253001756 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 363253001757 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253001758 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 363253001759 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 363253001760 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 363253001761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253001762 active site 363253001763 phosphorylation site [posttranslational modification] 363253001764 intermolecular recognition site; other site 363253001765 dimerization interface [polypeptide binding]; other site 363253001766 DNA-directed RNA polymerase specialized sigma subunit 363253001767 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 363253001768 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 363253001769 P-loop; other site 363253001770 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 363253001771 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 363253001772 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 363253001773 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 363253001774 FHIPEP family; Region: FHIPEP; pfam00771 363253001775 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 363253001776 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 363253001777 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 363253001778 ribosome maturation protein RimP; Reviewed; Region: PRK00092 363253001779 Sm and related proteins; Region: Sm_like; cl00259 363253001780 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 363253001781 putative oligomer interface [polypeptide binding]; other site 363253001782 putative RNA binding site [nucleotide binding]; other site 363253001783 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 363253001784 NusA N-terminal domain; Region: NusA_N; pfam08529 363253001785 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 363253001786 RNA binding site [nucleotide binding]; other site 363253001787 homodimer interface [polypeptide binding]; other site 363253001788 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 363253001789 G-X-X-G motif; other site 363253001790 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 363253001791 G-X-X-G motif; other site 363253001792 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 363253001793 translation initiation factor IF-2; Validated; Region: infB; PRK05306 363253001794 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 363253001795 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 363253001796 G1 box; other site 363253001797 putative GEF interaction site [polypeptide binding]; other site 363253001798 GTP/Mg2+ binding site [chemical binding]; other site 363253001799 Switch I region; other site 363253001800 G2 box; other site 363253001801 G3 box; other site 363253001802 Switch II region; other site 363253001803 G4 box; other site 363253001804 G5 box; other site 363253001805 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 363253001806 Translation-initiation factor 2; Region: IF-2; pfam11987 363253001807 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 363253001808 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 363253001809 DHH family; Region: DHH; pfam01368 363253001810 type III secretion system protein YscR; Provisional; Region: PRK12797 363253001811 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 363253001812 Type III secretion protein YscO; Region: YscO; pfam07321 363253001813 type III secretion system ATPase; Provisional; Region: PRK06936 363253001814 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 363253001815 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 363253001816 Walker A motif/ATP binding site; other site 363253001817 Walker B motif; other site 363253001818 type III secretion system protein; Reviewed; Region: PRK06937 363253001819 Flagellar assembly protein FliH; Region: FliH; pfam02108 363253001820 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 363253001821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001822 TPR motif; other site 363253001823 binding surface 363253001824 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 363253001825 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 363253001826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001827 TPR repeat; Region: TPR_11; pfam13414 363253001828 binding surface 363253001829 TPR motif; other site 363253001830 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 363253001831 FHIPEP family; Region: FHIPEP; pfam00771 363253001832 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 363253001833 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 363253001834 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 363253001835 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 363253001836 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 363253001837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 363253001838 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 363253001839 ATP binding site [chemical binding]; other site 363253001840 Mg2+ binding site [ion binding]; other site 363253001841 G-X-G motif; other site 363253001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 363253001843 active site 363253001844 phosphorylation site [posttranslational modification] 363253001845 intermolecular recognition site; other site 363253001846 dimerization interface [polypeptide binding]; other site 363253001847 diaminopimelate decarboxylase; Region: lysA; TIGR01048 363253001848 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 363253001849 active site 363253001850 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 363253001851 substrate binding site [chemical binding]; other site 363253001852 catalytic residues [active] 363253001853 dimer interface [polypeptide binding]; other site 363253001854 histidinol dehydrogenase; Region: hisD; TIGR00069 363253001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253001856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 363253001857 putative substrate translocation pore; other site 363253001858 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 363253001859 HD domain; Region: HD_3; pfam13023 363253001860 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 363253001861 23S rRNA interface [nucleotide binding]; other site 363253001862 L3 interface [polypeptide binding]; other site 363253001863 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 363253001864 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 363253001865 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 363253001866 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 363253001867 CHASE3 domain; Region: CHASE3; cl05000 363253001868 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 363253001869 tetramer interfaces [polypeptide binding]; other site 363253001870 binuclear metal-binding site [ion binding]; other site 363253001871 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 363253001872 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 363253001873 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 363253001874 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 363253001875 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 363253001876 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 363253001877 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 363253001878 Poxvirus P4A protein; Region: Pox_P4A; pfam03395 363253001879 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 363253001880 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253001881 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253001882 putative active site [active] 363253001883 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 363253001884 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 363253001885 ribonuclease III; Reviewed; Region: rnc; PRK00102 363253001886 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 363253001887 dimerization interface [polypeptide binding]; other site 363253001888 active site 363253001889 metal binding site [ion binding]; metal-binding site 363253001890 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 363253001891 dsRNA binding site [nucleotide binding]; other site 363253001892 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 363253001893 RimM N-terminal domain; Region: RimM; pfam01782 363253001894 PRC-barrel domain; Region: PRC; pfam05239 363253001895 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 363253001896 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 363253001897 signal recognition particle protein; Provisional; Region: PRK10867 363253001898 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 363253001899 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 363253001900 P loop; other site 363253001901 GTP binding site [chemical binding]; other site 363253001902 Signal peptide binding domain; Region: SRP_SPB; pfam02978 363253001903 TRAM domain; Region: TRAM; pfam01938 363253001904 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 363253001905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253001906 S-adenosylmethionine binding site [chemical binding]; other site 363253001907 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 363253001908 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 363253001909 substrate binding site; other site 363253001910 tetramer interface; other site 363253001911 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 363253001912 purine monophosphate binding site [chemical binding]; other site 363253001913 dimer interface [polypeptide binding]; other site 363253001914 putative catalytic residues [active] 363253001915 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 363253001916 active site 363253001917 8-oxo-dGMP binding site [chemical binding]; other site 363253001918 nudix motif; other site 363253001919 metal binding site [ion binding]; metal-binding site 363253001920 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 363253001921 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 363253001922 putative NAD(P) binding site [chemical binding]; other site 363253001923 active site 363253001924 putative substrate binding site [chemical binding]; other site 363253001925 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 363253001926 Flavoprotein; Region: Flavoprotein; pfam02441 363253001927 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 363253001928 TPR repeat; Region: TPR_11; pfam13414 363253001929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001930 binding surface 363253001931 TPR motif; other site 363253001932 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 363253001933 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 363253001934 active site 363253001935 metal binding site [ion binding]; metal-binding site 363253001936 DNA binding site [nucleotide binding] 363253001937 AAA domain; Region: AAA_23; pfam13476 363253001938 P-loop containing region of AAA domain; Region: AAA_29; cl17516 363253001939 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 363253001940 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 363253001941 GMP synthase; Reviewed; Region: guaA; PRK00074 363253001942 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 363253001943 AMP/PPi binding site [chemical binding]; other site 363253001944 candidate oxyanion hole; other site 363253001945 catalytic triad [active] 363253001946 potential glutamine specificity residues [chemical binding]; other site 363253001947 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 363253001948 ATP Binding subdomain [chemical binding]; other site 363253001949 Ligand Binding sites [chemical binding]; other site 363253001950 Dimerization subdomain; other site 363253001951 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 363253001952 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 363253001953 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 363253001954 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 363253001955 active site 363253001956 maltose O-acetyltransferase; Provisional; Region: PRK10092 363253001957 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 363253001958 active site 363253001959 substrate binding site [chemical binding]; other site 363253001960 trimer interface [polypeptide binding]; other site 363253001961 CoA binding site [chemical binding]; other site 363253001962 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 363253001963 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 363253001964 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 363253001965 putative active site [active] 363253001966 catalytic site [active] 363253001967 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 363253001968 putative active site [active] 363253001969 catalytic site [active] 363253001970 ribonuclease R; Region: RNase_R; TIGR02063 363253001971 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 363253001972 RNB domain; Region: RNB; pfam00773 363253001973 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 363253001974 RNA binding site [nucleotide binding]; other site 363253001975 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 363253001976 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 363253001977 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 363253001978 dimer interface [polypeptide binding]; other site 363253001979 catalytic triad [active] 363253001980 peroxidatic and resolving cysteines [active] 363253001981 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 363253001982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 363253001983 metal binding site [ion binding]; metal-binding site 363253001984 active site 363253001985 I-site; other site 363253001986 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 363253001987 nucleotidyl binding site; other site 363253001988 metal binding site [ion binding]; metal-binding site 363253001989 TPR repeat; Region: TPR_11; pfam13414 363253001990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001991 TPR motif; other site 363253001992 binding surface 363253001993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253001994 binding surface 363253001995 TPR repeat; Region: TPR_11; pfam13414 363253001996 TPR motif; other site 363253001997 TPR repeat; Region: TPR_11; pfam13414 363253001998 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 363253001999 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 363253002000 metal-binding site [ion binding] 363253002001 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 363253002002 Soluble P-type ATPase [General function prediction only]; Region: COG4087 363253002003 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 363253002004 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 363253002005 Na binding site [ion binding]; other site 363253002006 Protein of unknown function (DUF997); Region: DUF997; pfam06196 363253002007 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 363253002008 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 363253002009 Cl- selectivity filter; other site 363253002010 Cl- binding residues [ion binding]; other site 363253002011 pore gating glutamate residue; other site 363253002012 dimer interface [polypeptide binding]; other site 363253002013 H+/Cl- coupling transport residue; other site 363253002014 Protein of unknown function DUF45; Region: DUF45; pfam01863 363253002015 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 363253002016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 363253002017 DNA binding residues [nucleotide binding] 363253002018 dimerization interface [polypeptide binding]; other site 363253002019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 363253002020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 363253002021 metal binding site [ion binding]; metal-binding site 363253002022 active site 363253002023 I-site; other site 363253002024 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 363253002025 diiron binding motif [ion binding]; other site 363253002026 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 363253002027 Transcriptional regulators [Transcription]; Region: GntR; COG1802 363253002028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 363253002029 DNA-binding site [nucleotide binding]; DNA binding site 363253002030 FCD domain; Region: FCD; pfam07729 363253002031 Peptidase family M48; Region: Peptidase_M48; pfam01435 363253002032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002033 binding surface 363253002034 TPR motif; other site 363253002035 TPR repeat; Region: TPR_11; pfam13414 363253002036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002037 binding surface 363253002038 TPR motif; other site 363253002039 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 363253002040 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 363253002041 active site 363253002042 HIGH motif; other site 363253002043 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 363253002044 KMSKS motif; other site 363253002045 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 363253002046 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 363253002047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002048 binding surface 363253002049 TPR motif; other site 363253002050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002051 binding surface 363253002052 TPR motif; other site 363253002053 Tetratricopeptide repeat; Region: TPR_16; pfam13432 363253002054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002055 binding surface 363253002056 TPR motif; other site 363253002057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002058 binding surface 363253002059 TPR motif; other site 363253002060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002061 binding surface 363253002062 TPR motif; other site 363253002063 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 363253002064 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 363253002065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 363253002066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 363253002067 DNA binding residues [nucleotide binding] 363253002068 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 363253002069 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 363253002070 catalytic residues [active] 363253002071 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 363253002072 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 363253002073 DNA repair protein RadA; Provisional; Region: PRK11823 363253002074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 363253002075 Walker A motif; other site 363253002076 ATP binding site [chemical binding]; other site 363253002077 Walker B motif; other site 363253002078 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 363253002079 Uncharacterized conserved protein [Function unknown]; Region: COG2127 363253002080 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 363253002081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002082 Walker A motif; other site 363253002083 ATP binding site [chemical binding]; other site 363253002084 Walker B motif; other site 363253002085 arginine finger; other site 363253002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002087 Walker A motif; other site 363253002088 ATP binding site [chemical binding]; other site 363253002089 Walker B motif; other site 363253002090 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 363253002091 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 363253002092 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 363253002093 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 363253002094 active site 363253002095 Zn binding site [ion binding]; other site 363253002096 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 363253002097 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 363253002098 NADP binding site [chemical binding]; other site 363253002099 homopentamer interface [polypeptide binding]; other site 363253002100 substrate binding site [chemical binding]; other site 363253002101 active site 363253002102 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 363253002103 GTP1/OBG; Region: GTP1_OBG; pfam01018 363253002104 Obg GTPase; Region: Obg; cd01898 363253002105 G1 box; other site 363253002106 GTP/Mg2+ binding site [chemical binding]; other site 363253002107 Switch I region; other site 363253002108 G2 box; other site 363253002109 G3 box; other site 363253002110 Switch II region; other site 363253002111 G4 box; other site 363253002112 G5 box; other site 363253002113 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 363253002114 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 363253002115 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 363253002116 oligomerisation interface [polypeptide binding]; other site 363253002117 mobile loop; other site 363253002118 roof hairpin; other site 363253002119 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 363253002120 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 363253002121 ring oligomerisation interface [polypeptide binding]; other site 363253002122 ATP/Mg binding site [chemical binding]; other site 363253002123 stacking interactions; other site 363253002124 hinge regions; other site 363253002125 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 363253002126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253002127 S-adenosylmethionine binding site [chemical binding]; other site 363253002128 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 363253002129 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 363253002130 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 363253002131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253002132 ATP binding site [chemical binding]; other site 363253002133 Mg2+ binding site [ion binding]; other site 363253002134 G-X-G motif; other site 363253002135 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 363253002136 ATP binding site [chemical binding]; other site 363253002137 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 363253002138 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 363253002139 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 363253002140 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 363253002141 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 363253002142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 363253002143 nucleotide binding region [chemical binding]; other site 363253002144 ATP-binding site [chemical binding]; other site 363253002145 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 363253002146 dimerization interface [polypeptide binding]; other site 363253002147 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 363253002148 ATP binding site [chemical binding]; other site 363253002149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253002150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 363253002151 putative substrate translocation pore; other site 363253002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253002153 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 363253002154 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 363253002155 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 363253002156 acyl-activating enzyme (AAE) consensus motif; other site 363253002157 active site 363253002158 AMP binding site [chemical binding]; other site 363253002159 CoA binding site [chemical binding]; other site 363253002160 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 363253002161 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 363253002162 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 363253002163 DNA binding site [nucleotide binding] 363253002164 catalytic residue [active] 363253002165 H2TH interface [polypeptide binding]; other site 363253002166 putative catalytic residues [active] 363253002167 turnover-facilitating residue; other site 363253002168 intercalation triad [nucleotide binding]; other site 363253002169 8OG recognition residue [nucleotide binding]; other site 363253002170 putative reading head residues; other site 363253002171 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 363253002172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 363253002173 Cupin domain; Region: Cupin_2; cl17218 363253002174 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 363253002175 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 363253002176 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 363253002177 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 363253002178 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 363253002179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 363253002180 catalytic residue [active] 363253002181 GTPase Era; Reviewed; Region: era; PRK00089 363253002182 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 363253002183 G1 box; other site 363253002184 GTP/Mg2+ binding site [chemical binding]; other site 363253002185 Switch I region; other site 363253002186 G2 box; other site 363253002187 Switch II region; other site 363253002188 G3 box; other site 363253002189 G4 box; other site 363253002190 G5 box; other site 363253002191 KH domain; Region: KH_2; pfam07650 363253002192 Peptidase family M48; Region: Peptidase_M48; cl12018 363253002193 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 363253002194 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 363253002195 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 363253002196 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 363253002197 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 363253002198 phosphate binding site [ion binding]; other site 363253002199 putative substrate binding pocket [chemical binding]; other site 363253002200 dimer interface [polypeptide binding]; other site 363253002201 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 363253002202 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 363253002203 active site 363253002204 HIGH motif; other site 363253002205 nucleotide binding site [chemical binding]; other site 363253002206 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 363253002207 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 363253002208 active site 363253002209 KMSKS motif; other site 363253002210 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 363253002211 tRNA binding surface [nucleotide binding]; other site 363253002212 anticodon binding site; other site 363253002213 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 363253002214 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 363253002215 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 363253002216 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 363253002217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 363253002218 Peptidase M16C associated; Region: M16C_assoc; pfam08367 363253002219 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 363253002220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 363253002221 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 363253002222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 363253002223 active site residue [active] 363253002224 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 363253002225 Peptidase family M48; Region: Peptidase_M48; pfam01435 363253002226 DNA topoisomerase I; Validated; Region: PRK06599 363253002227 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 363253002228 active site 363253002229 interdomain interaction site; other site 363253002230 putative metal-binding site [ion binding]; other site 363253002231 nucleotide binding site [chemical binding]; other site 363253002232 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 363253002233 domain I; other site 363253002234 DNA binding groove [nucleotide binding] 363253002235 phosphate binding site [ion binding]; other site 363253002236 domain II; other site 363253002237 domain III; other site 363253002238 nucleotide binding site [chemical binding]; other site 363253002239 catalytic site [active] 363253002240 domain IV; other site 363253002241 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 363253002242 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 363253002243 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 363253002244 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 363253002245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 363253002246 argininosuccinate synthase; Provisional; Region: PRK13820 363253002247 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 363253002248 ANP binding site [chemical binding]; other site 363253002249 Substrate Binding Site II [chemical binding]; other site 363253002250 Substrate Binding Site I [chemical binding]; other site 363253002251 argininosuccinate lyase; Provisional; Region: PRK00855 363253002252 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 363253002253 active sites [active] 363253002254 tetramer interface [polypeptide binding]; other site 363253002255 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 363253002256 Domain of unknown function (DUF814); Region: DUF814; pfam05670 363253002257 Shikimate kinase; Region: SKI; pfam01202 363253002258 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 363253002259 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 363253002260 Ferritin-like domain; Region: Ferritin; pfam00210 363253002261 heme binding site [chemical binding]; other site 363253002262 ferroxidase pore; other site 363253002263 ferroxidase diiron center [ion binding]; other site 363253002264 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 363253002265 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 363253002266 glutaminase active site [active] 363253002267 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 363253002268 dimer interface [polypeptide binding]; other site 363253002269 active site 363253002270 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 363253002271 dimer interface [polypeptide binding]; other site 363253002272 active site 363253002273 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 363253002274 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 363253002275 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 363253002276 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 363253002277 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 363253002278 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 363253002279 Autotransporter beta-domain; Region: Autotransporter; cl17461 363253002280 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253002281 Adenosylhomocysteinase; Provisional; Region: PTZ00075 363253002282 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 363253002283 homotetramer interface [polypeptide binding]; other site 363253002284 ligand binding site [chemical binding]; other site 363253002285 catalytic site [active] 363253002286 NAD binding site [chemical binding]; other site 363253002287 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 363253002288 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 363253002289 putative ligand binding site [chemical binding]; other site 363253002290 putative NAD binding site [chemical binding]; other site 363253002291 catalytic site [active] 363253002292 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 363253002293 Part of AAA domain; Region: AAA_19; pfam13245 363253002294 Family description; Region: UvrD_C_2; pfam13538 363253002295 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 363253002296 thiamine monophosphate kinase; Provisional; Region: PRK05731 363253002297 ATP binding site [chemical binding]; other site 363253002298 dimerization interface [polypeptide binding]; other site 363253002299 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 363253002300 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 363253002301 active site 363253002302 substrate binding site [chemical binding]; other site 363253002303 metal binding site [ion binding]; metal-binding site 363253002304 HflK protein; Region: hflK; TIGR01933 363253002305 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 363253002306 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 363253002307 HflC protein; Region: hflC; TIGR01932 363253002308 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 363253002309 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 363253002310 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 363253002311 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 363253002312 active site 363253002313 dimerization interface [polypeptide binding]; other site 363253002314 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 363253002315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253002316 FeS/SAM binding site; other site 363253002317 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 363253002318 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 363253002319 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 363253002320 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 363253002321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 363253002322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253002323 Zn2+ binding site [ion binding]; other site 363253002324 Mg2+ binding site [ion binding]; other site 363253002325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 363253002326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 363253002327 Coenzyme A binding pocket [chemical binding]; other site 363253002328 chaperone protein DnaJ; Provisional; Region: PRK14301 363253002329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 363253002330 HSP70 interaction site [polypeptide binding]; other site 363253002331 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 363253002332 substrate binding site [polypeptide binding]; other site 363253002333 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 363253002334 Zn binding sites [ion binding]; other site 363253002335 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 363253002336 dimer interface [polypeptide binding]; other site 363253002337 multifunctional aminopeptidase A; Provisional; Region: PRK00913 363253002338 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 363253002339 interface (dimer of trimers) [polypeptide binding]; other site 363253002340 Substrate-binding/catalytic site; other site 363253002341 Zn-binding sites [ion binding]; other site 363253002342 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 363253002343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253002344 active site 363253002345 phosphorylation site [posttranslational modification] 363253002346 intermolecular recognition site; other site 363253002347 dimerization interface [polypeptide binding]; other site 363253002348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002349 Walker A motif; other site 363253002350 ATP binding site [chemical binding]; other site 363253002351 Walker B motif; other site 363253002352 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 363253002353 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 363253002354 Surface antigen; Region: Bac_surface_Ag; pfam01103 363253002355 Family of unknown function (DUF490); Region: DUF490; pfam04357 363253002356 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 363253002357 dimer interface [polypeptide binding]; other site 363253002358 putative outer membrane lipoprotein; Provisional; Region: PRK09967 363253002359 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 363253002360 ligand binding site [chemical binding]; other site 363253002361 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 363253002362 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 363253002363 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 363253002364 TonB C terminal; Region: TonB_2; pfam13103 363253002365 TolA protein; Region: tolA_full; TIGR02794 363253002366 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 363253002367 TolR protein; Region: tolR; TIGR02801 363253002368 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 363253002369 Rubrerythrin [Energy production and conversion]; Region: COG1592 363253002370 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 363253002371 binuclear metal center [ion binding]; other site 363253002372 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 363253002373 iron binding site [ion binding]; other site 363253002374 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 363253002375 Rubredoxin; Region: Rubredoxin; pfam00301 363253002376 iron binding site [ion binding]; other site 363253002377 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253002378 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253002379 putative active site [active] 363253002380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002381 binding surface 363253002382 TPR motif; other site 363253002383 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 363253002384 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 363253002385 GIY-YIG motif/motif A; other site 363253002386 active site 363253002387 catalytic site [active] 363253002388 putative DNA binding site [nucleotide binding]; other site 363253002389 metal binding site [ion binding]; metal-binding site 363253002390 UvrB/uvrC motif; Region: UVR; pfam02151 363253002391 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 363253002392 Maf-like protein; Region: Maf; pfam02545 363253002393 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 363253002394 active site 363253002395 dimer interface [polypeptide binding]; other site 363253002396 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 363253002397 DHH family; Region: DHH; pfam01368 363253002398 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 363253002399 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 363253002400 putative dimer interface [polypeptide binding]; other site 363253002401 putative anticodon binding site; other site 363253002402 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 363253002403 homodimer interface [polypeptide binding]; other site 363253002404 motif 1; other site 363253002405 motif 2; other site 363253002406 active site 363253002407 motif 3; other site 363253002408 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 363253002409 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 363253002410 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 363253002411 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 363253002412 Part of AAA domain; Region: AAA_19; pfam13245 363253002413 Family description; Region: UvrD_C_2; pfam13538 363253002414 Acylphosphatase; Region: Acylphosphatase; pfam00708 363253002415 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 363253002416 HypF finger; Region: zf-HYPF; pfam07503 363253002417 HypF finger; Region: zf-HYPF; pfam07503 363253002418 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 363253002419 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 363253002420 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 363253002421 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 363253002422 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 363253002423 active site 363253002424 Riboflavin kinase; Region: Flavokinase; pfam01687 363253002425 flagellin; Provisional; Region: PRK12802 363253002426 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 363253002427 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 363253002428 Colicin V production protein; Region: Colicin_V; pfam02674 363253002429 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 363253002430 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 363253002431 heterodimer interface [polypeptide binding]; other site 363253002432 active site 363253002433 FMN binding site [chemical binding]; other site 363253002434 homodimer interface [polypeptide binding]; other site 363253002435 substrate binding site [chemical binding]; other site 363253002436 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 363253002437 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 363253002438 FAD binding pocket [chemical binding]; other site 363253002439 FAD binding motif [chemical binding]; other site 363253002440 phosphate binding motif [ion binding]; other site 363253002441 beta-alpha-beta structure motif; other site 363253002442 NAD binding pocket [chemical binding]; other site 363253002443 Iron coordination center [ion binding]; other site 363253002444 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 363253002445 heterotetramer interface [polypeptide binding]; other site 363253002446 active site pocket [active] 363253002447 cleavage site 363253002448 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 363253002449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 363253002450 RNA binding surface [nucleotide binding]; other site 363253002451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 363253002452 active site 363253002453 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 363253002454 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 363253002455 substrate binding pocket [chemical binding]; other site 363253002456 membrane-bound complex binding site; other site 363253002457 hinge residues; other site 363253002458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 363253002459 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 363253002460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253002461 putative PBP binding loops; other site 363253002462 dimer interface [polypeptide binding]; other site 363253002463 ABC-ATPase subunit interface; other site 363253002464 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 363253002465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253002466 Walker A/P-loop; other site 363253002467 ATP binding site [chemical binding]; other site 363253002468 Q-loop/lid; other site 363253002469 ABC transporter signature motif; other site 363253002470 Walker B; other site 363253002471 D-loop; other site 363253002472 H-loop/switch region; other site 363253002473 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 363253002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253002475 dimer interface [polypeptide binding]; other site 363253002476 conserved gate region; other site 363253002477 putative PBP binding loops; other site 363253002478 ABC-ATPase subunit interface; other site 363253002479 GTP-binding protein LepA; Provisional; Region: PRK05433 363253002480 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 363253002481 G1 box; other site 363253002482 putative GEF interaction site [polypeptide binding]; other site 363253002483 GTP/Mg2+ binding site [chemical binding]; other site 363253002484 Switch I region; other site 363253002485 G2 box; other site 363253002486 G3 box; other site 363253002487 Switch II region; other site 363253002488 G4 box; other site 363253002489 G5 box; other site 363253002490 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 363253002491 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 363253002492 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 363253002493 Membrane transport protein; Region: Mem_trans; cl09117 363253002494 MltA specific insert domain; Region: MltA; smart00925 363253002495 3D domain; Region: 3D; pfam06725 363253002496 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 363253002497 active site 363253002498 histidinol-phosphatase; Provisional; Region: PRK07328 363253002499 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 363253002500 active site 363253002501 dimer interface [polypeptide binding]; other site 363253002502 S-adenosylmethionine synthetase; Validated; Region: PRK05250 363253002503 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 363253002504 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 363253002505 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 363253002506 LytB protein; Region: LYTB; cl00507 363253002507 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 363253002508 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 363253002509 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 363253002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253002511 active site 363253002512 phosphorylation site [posttranslational modification] 363253002513 intermolecular recognition site; other site 363253002514 dimerization interface [polypeptide binding]; other site 363253002515 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 363253002516 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 363253002517 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 363253002518 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 363253002519 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 363253002520 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 363253002521 active site 363253002522 HslU subunit interaction site [polypeptide binding]; other site 363253002523 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 363253002524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 363253002525 substrate binding pocket [chemical binding]; other site 363253002526 membrane-bound complex binding site; other site 363253002527 hinge residues; other site 363253002528 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 363253002529 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 363253002530 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 363253002531 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 363253002532 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 363253002533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 363253002534 active site 363253002535 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 363253002536 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 363253002537 5S rRNA interface [nucleotide binding]; other site 363253002538 CTC domain interface [polypeptide binding]; other site 363253002539 L16 interface [polypeptide binding]; other site 363253002540 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 363253002541 putative active site [active] 363253002542 catalytic residue [active] 363253002543 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 363253002544 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 363253002545 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 363253002546 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 363253002547 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 363253002548 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 363253002549 SAF-like; Region: SAF_2; pfam13144 363253002550 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 363253002551 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 363253002552 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 363253002553 Flagellar L-ring protein; Region: FlgH; pfam02107 363253002554 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 363253002555 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 363253002556 Rod binding protein; Region: Rod-binding; cl01626 363253002557 FlgN protein; Region: FlgN; pfam05130 363253002558 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 363253002559 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 363253002560 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 363253002561 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 363253002562 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 363253002563 Global regulator protein family; Region: CsrA; pfam02599 363253002564 FliW protein; Region: FliW; cl00740 363253002565 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 363253002566 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 363253002567 putative substrate binding site [chemical binding]; other site 363253002568 putative ATP binding site [chemical binding]; other site 363253002569 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 363253002570 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 363253002571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002572 Walker A motif; other site 363253002573 ATP binding site [chemical binding]; other site 363253002574 Walker B motif; other site 363253002575 arginine finger; other site 363253002576 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 363253002577 putative transporter; Provisional; Region: PRK11660 363253002578 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 363253002579 Sulfate transporter family; Region: Sulfate_transp; pfam00916 363253002580 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 363253002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253002582 dimer interface [polypeptide binding]; other site 363253002583 conserved gate region; other site 363253002584 putative PBP binding loops; other site 363253002585 ABC-ATPase subunit interface; other site 363253002586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 363253002587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 363253002588 substrate binding pocket [chemical binding]; other site 363253002589 membrane-bound complex binding site; other site 363253002590 hinge residues; other site 363253002591 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 363253002592 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 363253002593 RNA binding site [nucleotide binding]; other site 363253002594 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 363253002595 RNA binding site [nucleotide binding]; other site 363253002596 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 363253002597 RNA binding site [nucleotide binding]; other site 363253002598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 363253002599 RNA binding site [nucleotide binding]; other site 363253002600 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 363253002601 RNA binding site [nucleotide binding]; other site 363253002602 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 363253002603 RNA binding site [nucleotide binding]; other site 363253002604 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 363253002605 RNA/DNA hybrid binding site [nucleotide binding]; other site 363253002606 active site 363253002607 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 363253002608 UbiA prenyltransferase family; Region: UbiA; pfam01040 363253002609 CAAX protease self-immunity; Region: Abi; pfam02517 363253002610 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 363253002611 UbiA prenyltransferase family; Region: UbiA; pfam01040 363253002612 thymidylate kinase; Validated; Region: tmk; PRK00698 363253002613 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 363253002614 TMP-binding site; other site 363253002615 ATP-binding site [chemical binding]; other site 363253002616 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 363253002617 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 363253002618 generic binding surface I; other site 363253002619 generic binding surface II; other site 363253002620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253002621 Zn2+ binding site [ion binding]; other site 363253002622 Mg2+ binding site [ion binding]; other site 363253002623 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 363253002624 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 363253002625 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 363253002626 intersubunit interface [polypeptide binding]; other site 363253002627 active site 363253002628 zinc binding site [ion binding]; other site 363253002629 Na+ binding site [ion binding]; other site 363253002630 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 363253002631 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 363253002632 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 363253002633 Protein of unknown function DUF116; Region: DUF116; pfam01976 363253002634 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 363253002635 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 363253002636 putative active site [active] 363253002637 substrate binding site [chemical binding]; other site 363253002638 putative cosubstrate binding site; other site 363253002639 catalytic site [active] 363253002640 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 363253002641 substrate binding site [chemical binding]; other site 363253002642 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 363253002643 active site 363253002644 catalytic residues [active] 363253002645 metal binding site [ion binding]; metal-binding site 363253002646 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 363253002647 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 363253002648 FMN binding site [chemical binding]; other site 363253002649 active site 363253002650 catalytic residues [active] 363253002651 substrate binding site [chemical binding]; other site 363253002652 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 363253002653 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 363253002654 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 363253002655 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 363253002656 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 363253002657 homodimer interface [polypeptide binding]; other site 363253002658 oligonucleotide binding site [chemical binding]; other site 363253002659 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 363253002660 Ligand Binding Site [chemical binding]; other site 363253002661 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 363253002662 putative cation:proton antiport protein; Provisional; Region: PRK10669 363253002663 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 363253002664 TrkA-N domain; Region: TrkA_N; pfam02254 363253002665 TrkA-C domain; Region: TrkA_C; pfam02080 363253002666 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 363253002667 TrkA-N domain; Region: TrkA_N; pfam02254 363253002668 TrkA-C domain; Region: TrkA_C; pfam02080 363253002669 TrkA-N domain; Region: TrkA_N; pfam02254 363253002670 TrkA-C domain; Region: TrkA_C; pfam02080 363253002671 Cation transport protein; Region: TrkH; cl17365 363253002672 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 363253002673 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 363253002674 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 363253002675 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 363253002676 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 363253002677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 363253002678 minor groove reading motif; other site 363253002679 helix-hairpin-helix signature motif; other site 363253002680 substrate binding pocket [chemical binding]; other site 363253002681 active site 363253002682 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 363253002683 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 363253002684 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 363253002685 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 363253002686 substrate binding site [chemical binding]; other site 363253002687 ATP binding site [chemical binding]; other site 363253002688 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 363253002689 dimer interface [polypeptide binding]; other site 363253002690 substrate binding site [chemical binding]; other site 363253002691 ATP binding site [chemical binding]; other site 363253002692 DNA gyrase subunit A; Validated; Region: PRK05560 363253002693 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 363253002694 CAP-like domain; other site 363253002695 active site 363253002696 primary dimer interface [polypeptide binding]; other site 363253002697 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 363253002698 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 363253002699 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 363253002700 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 363253002701 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 363253002702 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 363253002703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253002704 ATP binding site [chemical binding]; other site 363253002705 Mg2+ binding site [ion binding]; other site 363253002706 G-X-G motif; other site 363253002707 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 363253002708 anchoring element; other site 363253002709 dimer interface [polypeptide binding]; other site 363253002710 ATP binding site [chemical binding]; other site 363253002711 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 363253002712 active site 363253002713 putative metal-binding site [ion binding]; other site 363253002714 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 363253002715 DNA polymerase III subunit beta; Provisional; Region: PRK14947 363253002716 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 363253002717 putative DNA binding surface [nucleotide binding]; other site 363253002718 dimer interface [polypeptide binding]; other site 363253002719 beta-clamp/clamp loader binding surface; other site 363253002720 beta-clamp/translesion DNA polymerase binding surface; other site 363253002721 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 363253002722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002723 Walker A motif; other site 363253002724 ATP binding site [chemical binding]; other site 363253002725 Walker B motif; other site 363253002726 arginine finger; other site 363253002727 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 363253002728 DnaA box-binding interface [nucleotide binding]; other site 363253002729 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 363253002730 Peptidase family M23; Region: Peptidase_M23; pfam01551 363253002731 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 363253002732 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 363253002733 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 363253002734 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 363253002735 dimer interface [polypeptide binding]; other site 363253002736 PYR/PP interface [polypeptide binding]; other site 363253002737 TPP binding site [chemical binding]; other site 363253002738 substrate binding site [chemical binding]; other site 363253002739 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 363253002740 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 363253002741 TPP-binding site [chemical binding]; other site 363253002742 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 363253002743 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 363253002744 trigger factor; Region: tig; TIGR00115 363253002745 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 363253002746 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 363253002747 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 363253002748 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 363253002749 oligomer interface [polypeptide binding]; other site 363253002750 active site residues [active] 363253002751 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 363253002752 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 363253002753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002754 Walker A motif; other site 363253002755 ATP binding site [chemical binding]; other site 363253002756 Walker B motif; other site 363253002757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 363253002758 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 363253002759 Found in ATP-dependent protease La (LON); Region: LON; smart00464 363253002760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253002761 Walker A motif; other site 363253002762 ATP binding site [chemical binding]; other site 363253002763 Walker B motif; other site 363253002764 arginine finger; other site 363253002765 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 363253002766 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 363253002767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253002768 FeS/SAM binding site; other site 363253002769 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 363253002770 Ligand Binding Site [chemical binding]; other site 363253002771 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 363253002772 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 363253002773 Substrate binding site; other site 363253002774 Mg++ binding site; other site 363253002775 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 363253002776 active site 363253002777 substrate binding site [chemical binding]; other site 363253002778 CoA binding site [chemical binding]; other site 363253002779 ribonuclease Y; Region: RNase_Y; TIGR03319 363253002780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253002781 Zn2+ binding site [ion binding]; other site 363253002782 Mg2+ binding site [ion binding]; other site 363253002783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 363253002784 active site 363253002785 hypothetical protein; Provisional; Region: PRK10519 363253002786 Nucleoside recognition; Region: Gate; pfam07670 363253002787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 363253002788 acyl-activating enzyme (AAE) consensus motif; other site 363253002789 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 363253002790 AMP binding site [chemical binding]; other site 363253002791 active site 363253002792 CoA binding site [chemical binding]; other site 363253002793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 363253002794 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 363253002795 substrate binding site [chemical binding]; other site 363253002796 oxyanion hole (OAH) forming residues; other site 363253002797 trimer interface [polypeptide binding]; other site 363253002798 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 363253002799 CoenzymeA binding site [chemical binding]; other site 363253002800 subunit interaction site [polypeptide binding]; other site 363253002801 PHB binding site; other site 363253002802 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 363253002803 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 363253002804 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 363253002805 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 363253002806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 363253002807 RNA binding surface [nucleotide binding]; other site 363253002808 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 363253002809 active site 363253002810 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 363253002811 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 363253002812 CoA-binding site [chemical binding]; other site 363253002813 ATP-binding [chemical binding]; other site 363253002814 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 363253002815 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253002816 P-loop; other site 363253002817 Magnesium ion binding site [ion binding]; other site 363253002818 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253002819 Magnesium ion binding site [ion binding]; other site 363253002820 ParB-like nuclease domain; Region: ParB; smart00470 363253002821 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 363253002822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 363253002823 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 363253002824 putative ribose interaction site [chemical binding]; other site 363253002825 putative ADP binding site [chemical binding]; other site 363253002826 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 363253002827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253002828 FeS/SAM binding site; other site 363253002829 HemN C-terminal domain; Region: HemN_C; pfam06969 363253002830 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 363253002831 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 363253002832 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 363253002833 dihydroorotase; Validated; Region: pyrC; PRK09357 363253002834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 363253002835 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 363253002836 active site 363253002837 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 363253002838 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 363253002839 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 363253002840 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 363253002841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253002842 FeS/SAM binding site; other site 363253002843 hypothetical protein; Provisional; Region: PRK06361 363253002844 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 363253002845 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 363253002846 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 363253002847 active site 363253002848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253002849 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 363253002850 putative ADP-binding pocket [chemical binding]; other site 363253002851 O-Antigen ligase; Region: Wzy_C; pfam04932 363253002852 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 363253002853 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 363253002854 putative ligand binding site [chemical binding]; other site 363253002855 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 363253002856 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 363253002857 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 363253002858 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 363253002859 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 363253002860 Walker A/P-loop; other site 363253002861 ATP binding site [chemical binding]; other site 363253002862 Q-loop/lid; other site 363253002863 ABC transporter signature motif; other site 363253002864 Walker B; other site 363253002865 D-loop; other site 363253002866 H-loop/switch region; other site 363253002867 RNA polymerase III subunit Rpc25; Region: RNA_pol_Rbc25; pfam08292 363253002868 TOBE domain; Region: TOBE_2; pfam08402 363253002869 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 363253002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253002871 dimer interface [polypeptide binding]; other site 363253002872 conserved gate region; other site 363253002873 putative PBP binding loops; other site 363253002874 ABC-ATPase subunit interface; other site 363253002875 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 363253002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253002877 dimer interface [polypeptide binding]; other site 363253002878 conserved gate region; other site 363253002879 putative PBP binding loops; other site 363253002880 ABC-ATPase subunit interface; other site 363253002881 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 363253002882 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 363253002883 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 363253002884 Protein of unknown function (DUF935); Region: DUF935; pfam06074 363253002885 Mor transcription activator family; Region: Mor; cl02360 363253002886 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 363253002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 363253002888 non-specific DNA binding site [nucleotide binding]; other site 363253002889 salt bridge; other site 363253002890 sequence-specific DNA binding site [nucleotide binding]; other site 363253002891 Predicted transcriptional regulator [Transcription]; Region: COG2932 363253002892 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 363253002893 Catalytic site [active] 363253002894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 363253002895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253002896 TPR motif; other site 363253002897 binding surface 363253002898 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 363253002899 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 363253002900 hinge; other site 363253002901 active site 363253002902 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 363253002903 putative catalytic site [active] 363253002904 putative metal binding site [ion binding]; other site 363253002905 putative phosphate binding site [ion binding]; other site 363253002906 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 363253002907 hydroperoxidase II; Provisional; Region: katE; PRK11249 363253002908 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 363253002909 tetramer interface [polypeptide binding]; other site 363253002910 heme binding pocket [chemical binding]; other site 363253002911 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 363253002912 domain interactions; other site 363253002913 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 363253002914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 363253002915 dimerization interface [polypeptide binding]; other site 363253002916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 363253002917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 363253002918 dimer interface [polypeptide binding]; other site 363253002919 putative CheW interface [polypeptide binding]; other site 363253002920 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 363253002921 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 363253002922 Family description; Region: VCBS; pfam13517 363253002923 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253002924 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 363253002925 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 363253002926 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 363253002927 Glucose inhibited division protein A; Region: GIDA; pfam01134 363253002928 HD domain; Region: HD_3; pfam13023 363253002929 HI0933-like protein; Region: HI0933_like; pfam03486 363253002930 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 363253002931 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 363253002932 FMN binding site [chemical binding]; other site 363253002933 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 363253002934 dimer interface [polypeptide binding]; other site 363253002935 OsmC-like protein; Region: OsmC; pfam02566 363253002936 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 363253002937 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 363253002938 Walker A motif/ATP binding site; other site 363253002939 Walker B motif; other site 363253002940 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 363253002941 Flagellar assembly protein FliH; Region: FliH; pfam02108 363253002942 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 363253002943 FliG C-terminal domain; Region: FliG_C; pfam01706 363253002944 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 363253002945 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 363253002946 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 363253002947 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 363253002948 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 363253002949 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 363253002950 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 363253002951 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 363253002952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 363253002953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 363253002954 Walker A/P-loop; other site 363253002955 ATP binding site [chemical binding]; other site 363253002956 Q-loop/lid; other site 363253002957 ABC transporter signature motif; other site 363253002958 Walker B; other site 363253002959 D-loop; other site 363253002960 H-loop/switch region; other site 363253002961 Cobalt transport protein; Region: CbiQ; cl00463 363253002962 cobalt transport protein CbiM; Validated; Region: PRK06265 363253002963 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 363253002964 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 363253002965 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 363253002966 MviN-like protein; Region: MVIN; pfam03023 363253002967 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 363253002968 Competence protein; Region: Competence; pfam03772 363253002969 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 363253002970 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 363253002971 glutamate racemase; Provisional; Region: PRK00865 363253002972 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 363253002973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 363253002974 RNA binding surface [nucleotide binding]; other site 363253002975 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 363253002976 active site 363253002977 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 363253002978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 363253002979 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 363253002980 Walker A/P-loop; other site 363253002981 ATP binding site [chemical binding]; other site 363253002982 Q-loop/lid; other site 363253002983 ABC transporter signature motif; other site 363253002984 Walker B; other site 363253002985 D-loop; other site 363253002986 H-loop/switch region; other site 363253002987 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 363253002988 putative acyl-acceptor binding pocket; other site 363253002989 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 363253002990 putative acyl-acceptor binding pocket; other site 363253002991 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 363253002992 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 363253002993 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 363253002994 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 363253002995 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 363253002996 Potassium binding sites [ion binding]; other site 363253002997 Cesium cation binding sites [ion binding]; other site 363253002998 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14168 363253002999 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 363253003000 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 363253003001 homodimer interface [polypeptide binding]; other site 363253003002 NADP binding site [chemical binding]; other site 363253003003 substrate binding site [chemical binding]; other site 363253003004 16S rRNA methyltransferase B; Provisional; Region: PRK14902 363253003005 NusB family; Region: NusB; pfam01029 363253003006 putative RNA binding site [nucleotide binding]; other site 363253003007 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 363253003008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 363253003009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003010 active site 363253003011 phosphorylation site [posttranslational modification] 363253003012 intermolecular recognition site; other site 363253003013 dimerization interface [polypeptide binding]; other site 363253003014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003015 Walker A motif; other site 363253003016 ATP binding site [chemical binding]; other site 363253003017 Walker B motif; other site 363253003018 arginine finger; other site 363253003019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 363253003020 dimer interface [polypeptide binding]; other site 363253003021 phosphorylation site [posttranslational modification] 363253003022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253003023 ATP binding site [chemical binding]; other site 363253003024 Mg2+ binding site [ion binding]; other site 363253003025 G-X-G motif; other site 363253003026 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 363253003027 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 363253003028 active site 363253003029 dimer interface [polypeptide binding]; other site 363253003030 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 363253003031 dimer interface [polypeptide binding]; other site 363253003032 active site 363253003033 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 363253003034 Predicted permeases [General function prediction only]; Region: COG0795 363253003035 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 363253003036 Predicted permeases [General function prediction only]; Region: COG0795 363253003037 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 363253003038 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 363253003039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 363253003040 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 363253003041 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 363253003042 G1 box; other site 363253003043 putative GEF interaction site [polypeptide binding]; other site 363253003044 GTP/Mg2+ binding site [chemical binding]; other site 363253003045 Switch I region; other site 363253003046 G2 box; other site 363253003047 G3 box; other site 363253003048 Switch II region; other site 363253003049 G4 box; other site 363253003050 G5 box; other site 363253003051 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 363253003052 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 363253003053 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 363253003054 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 363253003055 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 363253003056 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 363253003057 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 363253003058 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 363253003059 Ligand Binding Site [chemical binding]; other site 363253003060 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 363253003061 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253003062 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 363253003063 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 363253003064 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 363253003065 putative active site [active] 363253003066 catalytic triad [active] 363253003067 putative dimer interface [polypeptide binding]; other site 363253003068 peptide chain release factor 2; Validated; Region: prfB; PRK00578 363253003069 This domain is found in peptide chain release factors; Region: PCRF; smart00937 363253003070 RF-1 domain; Region: RF-1; pfam00472 363253003071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 363253003072 IHF - DNA interface [nucleotide binding]; other site 363253003073 IHF dimer interface [polypeptide binding]; other site 363253003074 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 363253003075 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 363253003076 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 363253003077 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 363253003078 dihydrodipicolinate synthase; Region: dapA; TIGR00674 363253003079 dimer interface [polypeptide binding]; other site 363253003080 active site 363253003081 catalytic residue [active] 363253003082 MFS transport protein AraJ; Provisional; Region: PRK10091 363253003083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253003084 putative substrate translocation pore; other site 363253003085 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 363253003086 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 363253003087 active site 363253003088 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 363253003089 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 363253003090 DsrC like protein; Region: DsrC; pfam04358 363253003091 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 363253003092 metal ion-dependent adhesion site (MIDAS); other site 363253003093 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 363253003094 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 363253003095 ligand binding site [chemical binding]; other site 363253003096 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 363253003097 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 363253003098 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 363253003099 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 363253003100 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 363253003101 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 363253003102 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 363253003103 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 363253003104 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 363253003105 DNA binding site [nucleotide binding] 363253003106 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 363253003107 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 363253003108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 363253003109 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 363253003110 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 363253003111 RPB11 interaction site [polypeptide binding]; other site 363253003112 RPB12 interaction site [polypeptide binding]; other site 363253003113 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 363253003114 RPB3 interaction site [polypeptide binding]; other site 363253003115 RPB1 interaction site [polypeptide binding]; other site 363253003116 RPB11 interaction site [polypeptide binding]; other site 363253003117 RPB10 interaction site [polypeptide binding]; other site 363253003118 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 363253003119 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 363253003120 inhibitor-cofactor binding pocket; inhibition site 363253003121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253003122 catalytic residue [active] 363253003123 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 363253003124 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 363253003125 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 363253003126 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 363253003127 rRNA binding site [nucleotide binding]; other site 363253003128 predicted 30S ribosome binding site; other site 363253003129 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 363253003130 cytidylate kinase; Provisional; Region: cmk; PRK00023 363253003131 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 363253003132 CMP-binding site; other site 363253003133 The sites determining sugar specificity; other site 363253003134 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 363253003135 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 363253003136 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 363253003137 nucleotide binding site [chemical binding]; other site 363253003138 NEF interaction site [polypeptide binding]; other site 363253003139 SBD interface [polypeptide binding]; other site 363253003140 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 363253003141 Aspartase; Region: Aspartase; cd01357 363253003142 active sites [active] 363253003143 tetramer interface [polypeptide binding]; other site 363253003144 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 363253003145 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 363253003146 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 363253003147 homodimer interface [polypeptide binding]; other site 363253003148 substrate-cofactor binding pocket; other site 363253003149 catalytic residue [active] 363253003150 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 363253003151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003152 Walker A motif; other site 363253003153 ATP binding site [chemical binding]; other site 363253003154 Walker B motif; other site 363253003155 arginine finger; other site 363253003156 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 363253003157 hypothetical protein; Validated; Region: PRK00153 363253003158 recombination protein RecR; Reviewed; Region: recR; PRK00076 363253003159 RecR protein; Region: RecR; pfam02132 363253003160 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 363253003161 putative active site [active] 363253003162 putative metal-binding site [ion binding]; other site 363253003163 tetramer interface [polypeptide binding]; other site 363253003164 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 363253003165 active site 363253003166 substrate binding site [chemical binding]; other site 363253003167 catalytic site [active] 363253003168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 363253003169 Peptidase family M23; Region: Peptidase_M23; pfam01551 363253003170 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 363253003171 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 363253003172 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 363253003173 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 363253003174 AIR carboxylase; Region: AIRC; pfam00731 363253003175 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 363253003176 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 363253003177 Catalytic site [active] 363253003178 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 363253003179 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 363253003180 Sulfatase; Region: Sulfatase; cl17466 363253003181 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 363253003182 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 363253003183 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 363253003184 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 363253003185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 363253003186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 363253003187 active site 363253003188 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 363253003189 peripheral dimer interface [polypeptide binding]; other site 363253003190 core dimer interface [polypeptide binding]; other site 363253003191 L10 interface [polypeptide binding]; other site 363253003192 L11 interface [polypeptide binding]; other site 363253003193 putative EF-Tu interaction site [polypeptide binding]; other site 363253003194 putative EF-G interaction site [polypeptide binding]; other site 363253003195 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 363253003196 23S rRNA interface [nucleotide binding]; other site 363253003197 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 363253003198 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 363253003199 mRNA/rRNA interface [nucleotide binding]; other site 363253003200 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 363253003201 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 363253003202 23S rRNA interface [nucleotide binding]; other site 363253003203 L7/L12 interface [polypeptide binding]; other site 363253003204 putative thiostrepton binding site; other site 363253003205 L25 interface [polypeptide binding]; other site 363253003206 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 363253003207 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 363253003208 putative homodimer interface [polypeptide binding]; other site 363253003209 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 363253003210 heterodimer interface [polypeptide binding]; other site 363253003211 homodimer interface [polypeptide binding]; other site 363253003212 elongation factor Tu; Reviewed; Region: PRK00049 363253003213 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 363253003214 G1 box; other site 363253003215 GEF interaction site [polypeptide binding]; other site 363253003216 GTP/Mg2+ binding site [chemical binding]; other site 363253003217 Switch I region; other site 363253003218 G2 box; other site 363253003219 G3 box; other site 363253003220 Switch II region; other site 363253003221 G4 box; other site 363253003222 G5 box; other site 363253003223 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 363253003224 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 363253003225 Antibiotic Binding Site [chemical binding]; other site 363253003226 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 363253003227 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 363253003228 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 363253003229 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 363253003230 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 363253003231 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 363253003232 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 363253003233 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 363253003234 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 363253003235 active site 363253003236 tetramer interface [polypeptide binding]; other site 363253003237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 363253003238 active site 363253003239 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 363253003240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 363253003241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 363253003242 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 363253003243 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 363253003244 ATP-grasp domain; Region: ATP-grasp_4; cl17255 363253003245 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 363253003246 IMP binding site; other site 363253003247 dimer interface [polypeptide binding]; other site 363253003248 partial ornithine binding site; other site 363253003249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 363253003250 nudix motif; other site 363253003251 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 363253003252 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 363253003253 Transporter associated domain; Region: CorC_HlyC; smart01091 363253003254 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 363253003255 S17 interaction site [polypeptide binding]; other site 363253003256 S8 interaction site; other site 363253003257 16S rRNA interaction site [nucleotide binding]; other site 363253003258 streptomycin interaction site [chemical binding]; other site 363253003259 23S rRNA interaction site [nucleotide binding]; other site 363253003260 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 363253003261 30S ribosomal protein S7; Validated; Region: PRK05302 363253003262 elongation factor G; Reviewed; Region: PRK00007 363253003263 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 363253003264 G1 box; other site 363253003265 putative GEF interaction site [polypeptide binding]; other site 363253003266 GTP/Mg2+ binding site [chemical binding]; other site 363253003267 Switch I region; other site 363253003268 G2 box; other site 363253003269 G3 box; other site 363253003270 Switch II region; other site 363253003271 G4 box; other site 363253003272 G5 box; other site 363253003273 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 363253003274 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 363253003275 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 363253003276 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 363253003277 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 363253003278 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 363253003279 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 363253003280 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 363253003281 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 363253003282 NlpC/P60 family; Region: NLPC_P60; pfam00877 363253003283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253003284 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253003285 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 363253003286 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 363253003287 homodimer interface [polypeptide binding]; other site 363253003288 substrate-cofactor binding pocket; other site 363253003289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253003290 catalytic residue [active] 363253003291 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 363253003292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 363253003293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003294 TPR repeat; Region: TPR_11; pfam13414 363253003295 binding surface 363253003296 TPR motif; other site 363253003297 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 363253003298 CcmB protein; Region: CcmB; cl17444 363253003299 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 363253003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253003301 Walker A/P-loop; other site 363253003302 ATP binding site [chemical binding]; other site 363253003303 Q-loop/lid; other site 363253003304 ABC transporter signature motif; other site 363253003305 Walker B; other site 363253003306 D-loop; other site 363253003307 H-loop/switch region; other site 363253003308 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 363253003309 CcmE; Region: CcmE; cl00994 363253003310 Domain of unknown function DUF21; Region: DUF21; pfam01595 363253003311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 363253003312 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 363253003313 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 363253003314 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 363253003315 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 363253003316 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 363253003317 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 363253003318 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 363253003319 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 363253003320 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 363253003321 putative translocon binding site; other site 363253003322 protein-rRNA interface [nucleotide binding]; other site 363253003323 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 363253003324 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 363253003325 G-X-X-G motif; other site 363253003326 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 363253003327 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 363253003328 23S rRNA interface [nucleotide binding]; other site 363253003329 5S rRNA interface [nucleotide binding]; other site 363253003330 putative antibiotic binding site [chemical binding]; other site 363253003331 L25 interface [polypeptide binding]; other site 363253003332 L27 interface [polypeptide binding]; other site 363253003333 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 363253003334 trigger factor interaction site; other site 363253003335 23S rRNA interface [nucleotide binding]; other site 363253003336 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 363253003337 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 363253003338 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 363253003339 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 363253003340 RNA binding site [nucleotide binding]; other site 363253003341 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 363253003342 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 363253003343 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 363253003344 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 363253003345 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 363253003346 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 363253003347 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 363253003348 5S rRNA interface [nucleotide binding]; other site 363253003349 L27 interface [polypeptide binding]; other site 363253003350 23S rRNA interface [nucleotide binding]; other site 363253003351 L5 interface [polypeptide binding]; other site 363253003352 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 363253003353 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 363253003354 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 363253003355 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 363253003356 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 363253003357 SecY translocase; Region: SecY; pfam00344 363253003358 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 363253003359 active site 363253003360 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 363253003361 30S ribosomal protein S13; Region: bact_S13; TIGR03631 363253003362 30S ribosomal protein S11; Validated; Region: PRK05309 363253003363 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 363253003364 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 363253003365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 363253003366 RNA binding surface [nucleotide binding]; other site 363253003367 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 363253003368 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 363253003369 alphaNTD - beta interaction site [polypeptide binding]; other site 363253003370 alphaNTD homodimer interface [polypeptide binding]; other site 363253003371 alphaNTD - beta' interaction site [polypeptide binding]; other site 363253003372 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 363253003373 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 363253003374 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 363253003375 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 363253003376 Substrate binding site; other site 363253003377 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 363253003378 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 363253003379 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 363253003380 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 363253003381 dimer interface [polypeptide binding]; other site 363253003382 motif 1; other site 363253003383 active site 363253003384 motif 2; other site 363253003385 motif 3; other site 363253003386 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 363253003387 anticodon binding site; other site 363253003388 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 363253003389 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 363253003390 dimer interface [polypeptide binding]; other site 363253003391 anticodon binding site; other site 363253003392 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 363253003393 homodimer interface [polypeptide binding]; other site 363253003394 motif 1; other site 363253003395 active site 363253003396 motif 2; other site 363253003397 GAD domain; Region: GAD; pfam02938 363253003398 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 363253003399 active site 363253003400 motif 3; other site 363253003401 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 363253003402 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 363253003403 Walker A/P-loop; other site 363253003404 ATP binding site [chemical binding]; other site 363253003405 Q-loop/lid; other site 363253003406 ABC transporter signature motif; other site 363253003407 Walker B; other site 363253003408 D-loop; other site 363253003409 H-loop/switch region; other site 363253003410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 363253003411 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 363253003412 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 363253003413 Ligand binding site; other site 363253003414 oligomer interface; other site 363253003415 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 363253003416 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 363253003417 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 363253003418 catalytic site [active] 363253003419 subunit interface [polypeptide binding]; other site 363253003420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003421 binding surface 363253003422 TPR motif; other site 363253003423 TPR repeat; Region: TPR_11; pfam13414 363253003424 TPR repeat; Region: TPR_11; pfam13414 363253003425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003426 binding surface 363253003427 TPR motif; other site 363253003428 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 363253003429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 363253003430 HlyD family secretion protein; Region: HlyD_3; pfam13437 363253003431 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 363253003432 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 363253003433 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 363253003434 adenylosuccinate lyase; Provisional; Region: PRK07492 363253003435 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 363253003436 tetramer interface [polypeptide binding]; other site 363253003437 active site 363253003438 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 363253003439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 363253003440 active site 363253003441 SnoaL-like domain; Region: SnoaL_3; pfam13474 363253003442 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 363253003443 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 363253003444 Cytochrome c552; Region: Cytochrom_C552; pfam02335 363253003445 aspartate kinase; Reviewed; Region: PRK06635 363253003446 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 363253003447 putative catalytic residues [active] 363253003448 putative nucleotide binding site [chemical binding]; other site 363253003449 putative aspartate binding site [chemical binding]; other site 363253003450 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 363253003451 putative allosteric regulatory site; other site 363253003452 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 363253003453 putative allosteric regulatory residue; other site 363253003454 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 363253003455 AAA domain; Region: AAA_22; pfam13401 363253003456 tRNA pseudouridine synthase B; Provisional; Region: PRK14124 363253003457 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 363253003458 RNA binding site [nucleotide binding]; other site 363253003459 active site 363253003460 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 363253003461 16S/18S rRNA binding site [nucleotide binding]; other site 363253003462 S13e-L30e interaction site [polypeptide binding]; other site 363253003463 25S rRNA binding site [nucleotide binding]; other site 363253003464 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 363253003465 polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591 363253003466 RNase E interface [polypeptide binding]; other site 363253003467 trimer interface [polypeptide binding]; other site 363253003468 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 363253003469 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 363253003470 RNase E interface [polypeptide binding]; other site 363253003471 trimer interface [polypeptide binding]; other site 363253003472 active site 363253003473 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 363253003474 putative nucleic acid binding region [nucleotide binding]; other site 363253003475 G-X-X-G motif; other site 363253003476 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 363253003477 RNA binding site [nucleotide binding]; other site 363253003478 domain interface; other site 363253003479 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 363253003480 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 363253003481 GatB domain; Region: GatB_Yqey; smart00845 363253003482 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 363253003483 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 363253003484 ATP-NAD kinase; Region: NAD_kinase; pfam01513 363253003485 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 363253003486 dimer interface [polypeptide binding]; other site 363253003487 active site 363253003488 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 363253003489 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 363253003490 domain interfaces; other site 363253003491 active site 363253003492 AAA domain; Region: AAA_32; pfam13654 363253003493 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 363253003494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253003495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 363253003496 putative substrate translocation pore; other site 363253003497 Oligomerisation domain; Region: Oligomerisation; pfam02410 363253003498 phosphoglyceromutase; Provisional; Region: PRK05434 363253003499 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 363253003500 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 363253003501 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 363253003502 putative active site [active] 363253003503 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 363253003504 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 363253003505 active site 363253003506 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 363253003507 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 363253003508 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 363253003509 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 363253003510 trimer interface [polypeptide binding]; other site 363253003511 active site 363253003512 UDP-GlcNAc binding site [chemical binding]; other site 363253003513 lipid binding site [chemical binding]; lipid-binding site 363253003514 periplasmic chaperone; Provisional; Region: PRK10780 363253003515 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 363253003516 TPR repeat; Region: TPR_11; pfam13414 363253003517 Tetratricopeptide repeat; Region: TPR_6; pfam13174 363253003518 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 363253003519 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 363253003520 active site 363253003521 metal binding site [ion binding]; metal-binding site 363253003522 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 363253003523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 363253003524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 363253003525 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 363253003526 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 363253003527 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 363253003528 Surface antigen; Region: Bac_surface_Ag; pfam01103 363253003529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 363253003530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 363253003531 Walker A/P-loop; other site 363253003532 ATP binding site [chemical binding]; other site 363253003533 Q-loop/lid; other site 363253003534 ABC transporter signature motif; other site 363253003535 Walker B; other site 363253003536 D-loop; other site 363253003537 H-loop/switch region; other site 363253003538 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 363253003539 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 363253003540 FtsX-like permease family; Region: FtsX; pfam02687 363253003541 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 363253003542 dimer interface [polypeptide binding]; other site 363253003543 putative anticodon binding site; other site 363253003544 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 363253003545 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 363253003546 motif 1; other site 363253003547 active site 363253003548 motif 2; other site 363253003549 motif 3; other site 363253003550 PBP superfamily domain; Region: PBP_like_2; cl17296 363253003551 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 363253003552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253003553 dimer interface [polypeptide binding]; other site 363253003554 conserved gate region; other site 363253003555 putative PBP binding loops; other site 363253003556 ABC-ATPase subunit interface; other site 363253003557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 363253003558 dimer interface [polypeptide binding]; other site 363253003559 conserved gate region; other site 363253003560 putative PBP binding loops; other site 363253003561 ABC-ATPase subunit interface; other site 363253003562 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 363253003563 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 363253003564 Walker A/P-loop; other site 363253003565 ATP binding site [chemical binding]; other site 363253003566 Q-loop/lid; other site 363253003567 ABC transporter signature motif; other site 363253003568 Walker B; other site 363253003569 D-loop; other site 363253003570 H-loop/switch region; other site 363253003571 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 363253003572 Pleckstrin homology-like domain; Region: PH-like; cl17171 363253003573 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 363253003574 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 363253003575 putative ligand binding site [chemical binding]; other site 363253003576 putative NAD binding site [chemical binding]; other site 363253003577 catalytic site [active] 363253003578 Protein of unknown function (DUF330); Region: DUF330; pfam03886 363253003579 mce related protein; Region: MCE; pfam02470 363253003580 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 363253003581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253003582 Walker A/P-loop; other site 363253003583 ATP binding site [chemical binding]; other site 363253003584 Q-loop/lid; other site 363253003585 ABC transporter signature motif; other site 363253003586 Walker B; other site 363253003587 D-loop; other site 363253003588 H-loop/switch region; other site 363253003589 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 363253003590 Permease; Region: Permease; pfam02405 363253003591 GrpE; Region: GrpE; pfam01025 363253003592 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 363253003593 dimer interface [polypeptide binding]; other site 363253003594 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 363253003595 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 363253003596 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 363253003597 active site 363253003598 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 363253003599 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 363253003600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 363253003601 active site 363253003602 HIGH motif; other site 363253003603 nucleotide binding site [chemical binding]; other site 363253003604 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 363253003605 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 363253003606 active site 363253003607 KMSKS motif; other site 363253003608 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 363253003609 tRNA binding surface [nucleotide binding]; other site 363253003610 anticodon binding site; other site 363253003611 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 363253003612 lipoprotein signal peptidase; Provisional; Region: PRK14787 363253003613 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 363253003614 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 363253003615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003616 binding surface 363253003617 TPR motif; other site 363253003618 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 363253003619 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 363253003620 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 363253003621 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 363253003622 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 363253003623 ATP synthase subunit C; Region: ATP-synt_C; cl00466 363253003624 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 363253003625 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 363253003626 CoA binding domain; Region: CoA_binding; smart00881 363253003627 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 363253003628 Uncharacterized conserved protein [Function unknown]; Region: COG3334 363253003629 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 363253003630 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 363253003631 dimerization interface 3.5A [polypeptide binding]; other site 363253003632 active site 363253003633 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 363253003634 4Fe-4S binding domain; Region: Fer4; cl02805 363253003635 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 363253003636 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 363253003637 NADP binding site [chemical binding]; other site 363253003638 active site 363253003639 putative substrate binding site [chemical binding]; other site 363253003640 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 363253003641 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 363253003642 NAD binding site [chemical binding]; other site 363253003643 substrate binding site [chemical binding]; other site 363253003644 homodimer interface [polypeptide binding]; other site 363253003645 active site 363253003646 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 363253003647 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 363253003648 active site 363253003649 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 363253003650 active site 363253003651 Ribonuclease P; Region: Ribonuclease_P; cl00457 363253003652 membrane protein insertase; Provisional; Region: PRK01318 363253003653 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 363253003654 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 363253003655 G-X-X-G motif; other site 363253003656 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 363253003657 RxxxH motif; other site 363253003658 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 363253003659 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 363253003660 trmE is a tRNA modification GTPase; Region: trmE; cd04164 363253003661 G1 box; other site 363253003662 GTP/Mg2+ binding site [chemical binding]; other site 363253003663 Switch I region; other site 363253003664 G2 box; other site 363253003665 Switch II region; other site 363253003666 G3 box; other site 363253003667 G4 box; other site 363253003668 G5 box; other site 363253003669 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 363253003670 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 363253003671 catalytic site [active] 363253003672 putative active site [active] 363253003673 putative substrate binding site [chemical binding]; other site 363253003674 probable DNA repair protein; Region: TIGR03623 363253003675 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 363253003676 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 363253003677 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 363253003678 FMN binding site [chemical binding]; other site 363253003679 substrate binding site [chemical binding]; other site 363253003680 putative catalytic residue [active] 363253003681 Glucokinase; Region: Glucokinase; cl17310 363253003682 glucokinase, proteobacterial type; Region: glk; TIGR00749 363253003683 SprA-related family; Region: SprA-related; pfam12118 363253003684 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 363253003685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 363253003686 putative active site [active] 363253003687 heme pocket [chemical binding]; other site 363253003688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 363253003689 dimer interface [polypeptide binding]; other site 363253003690 phosphorylation site [posttranslational modification] 363253003691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253003692 ATP binding site [chemical binding]; other site 363253003693 Mg2+ binding site [ion binding]; other site 363253003694 G-X-G motif; other site 363253003695 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 363253003696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003697 active site 363253003698 phosphorylation site [posttranslational modification] 363253003699 intermolecular recognition site; other site 363253003700 dimerization interface [polypeptide binding]; other site 363253003701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003702 Walker A motif; other site 363253003703 ATP binding site [chemical binding]; other site 363253003704 Walker B motif; other site 363253003705 arginine finger; other site 363253003706 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 363253003707 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 363253003708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 363253003709 Walker A/P-loop; other site 363253003710 ATP binding site [chemical binding]; other site 363253003711 Q-loop/lid; other site 363253003712 ABC transporter signature motif; other site 363253003713 Walker B; other site 363253003714 D-loop; other site 363253003715 H-loop/switch region; other site 363253003716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 363253003717 FeoA domain; Region: FeoA; pfam04023 363253003718 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 363253003719 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 363253003720 G1 box; other site 363253003721 GTP/Mg2+ binding site [chemical binding]; other site 363253003722 Switch I region; other site 363253003723 G2 box; other site 363253003724 G3 box; other site 363253003725 Switch II region; other site 363253003726 G4 box; other site 363253003727 G5 box; other site 363253003728 Nucleoside recognition; Region: Gate; pfam07670 363253003729 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 363253003730 Nucleoside recognition; Region: Gate; pfam07670 363253003731 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 363253003732 Cysteine-rich domain; Region: CCG; pfam02754 363253003733 Cysteine-rich domain; Region: CCG; pfam02754 363253003734 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 363253003735 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 363253003736 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 363253003737 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 363253003738 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 363253003739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253003740 S-adenosylmethionine binding site [chemical binding]; other site 363253003741 nickel responsive regulator; Provisional; Region: PRK04460 363253003742 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 363253003743 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 363253003744 putative GTP cyclohydrolase; Provisional; Region: PRK13674 363253003745 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 363253003746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003747 Walker A motif; other site 363253003748 ATP binding site [chemical binding]; other site 363253003749 Walker B motif; other site 363253003750 arginine finger; other site 363253003751 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 363253003752 Tetratricopeptide repeat; Region: TPR_16; pfam13432 363253003753 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 363253003754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003755 binding surface 363253003756 TPR motif; other site 363253003757 Tetratricopeptide repeat; Region: TPR_6; pfam13174 363253003758 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 363253003759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253003760 Zn2+ binding site [ion binding]; other site 363253003761 Mg2+ binding site [ion binding]; other site 363253003762 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 363253003763 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 363253003764 domain interfaces; other site 363253003765 active site 363253003766 cell division protein MraZ; Reviewed; Region: PRK00326 363253003767 MraZ protein; Region: MraZ; pfam02381 363253003768 MraZ protein; Region: MraZ; pfam02381 363253003769 MraW methylase family; Region: Methyltransf_5; pfam01795 363253003770 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 363253003771 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 363253003772 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 363253003773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 363253003774 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 363253003775 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 363253003776 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 363253003777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 363253003778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 363253003779 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 363253003780 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 363253003781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 363253003782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 363253003783 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 363253003784 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 363253003785 Mg++ binding site [ion binding]; other site 363253003786 putative catalytic motif [active] 363253003787 putative substrate binding site [chemical binding]; other site 363253003788 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 363253003789 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 363253003790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 363253003791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 363253003792 cell division protein FtsW; Region: ftsW; TIGR02614 363253003793 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 363253003794 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 363253003795 active site 363253003796 homodimer interface [polypeptide binding]; other site 363253003797 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 363253003798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 363253003799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 363253003800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 363253003801 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 363253003802 FAD binding domain; Region: FAD_binding_4; pfam01565 363253003803 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 363253003804 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 363253003805 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 363253003806 cell division protein FtsA; Region: ftsA; TIGR01174 363253003807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 363253003808 nucleotide binding site [chemical binding]; other site 363253003809 Cell division protein FtsA; Region: FtsA; pfam14450 363253003810 cell division protein FtsZ; Validated; Region: PRK09330 363253003811 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 363253003812 nucleotide binding site [chemical binding]; other site 363253003813 SulA interaction site; other site 363253003814 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 363253003815 putative active site [active] 363253003816 putative metal binding residues [ion binding]; other site 363253003817 signature motif; other site 363253003818 putative dimer interface [polypeptide binding]; other site 363253003819 putative phosphate binding site [ion binding]; other site 363253003820 DNA utilization protein GntX; Provisional; Region: PRK11595 363253003821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 363253003822 active site 363253003823 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 363253003824 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 363253003825 ornithine carbamoyltransferase; Provisional; Region: PRK00779 363253003826 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 363253003827 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 363253003828 periplasmic folding chaperone; Provisional; Region: PRK10788 363253003829 SurA N-terminal domain; Region: SurA_N_3; cl07813 363253003830 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 363253003831 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 363253003832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003833 active site 363253003834 phosphorylation site [posttranslational modification] 363253003835 intermolecular recognition site; other site 363253003836 dimerization interface [polypeptide binding]; other site 363253003837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003838 Walker A motif; other site 363253003839 ATP binding site [chemical binding]; other site 363253003840 Walker B motif; other site 363253003841 arginine finger; other site 363253003842 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 363253003843 hybrid cluster protein; Provisional; Region: PRK05290 363253003844 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 363253003845 ACS interaction site; other site 363253003846 CODH interaction site; other site 363253003847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 363253003848 ACS interaction site; other site 363253003849 CODH interaction site; other site 363253003850 metal cluster binding site [ion binding]; other site 363253003851 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 363253003852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 363253003853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003854 active site 363253003855 phosphorylation site [posttranslational modification] 363253003856 intermolecular recognition site; other site 363253003857 dimerization interface [polypeptide binding]; other site 363253003858 LabA_like proteins; Region: LabA_like/DUF88; cl10034 363253003859 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 363253003860 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 363253003861 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 363253003862 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 363253003863 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 363253003864 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 363253003865 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 363253003866 active site 363253003867 multimer interface [polypeptide binding]; other site 363253003868 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 363253003869 NodB motif; other site 363253003870 putative active site [active] 363253003871 putative catalytic site [active] 363253003872 Zn binding site [ion binding]; other site 363253003873 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 363253003874 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 363253003875 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 363253003876 protein binding site [polypeptide binding]; other site 363253003877 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 363253003878 Catalytic dyad [active] 363253003879 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 363253003880 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 363253003881 minor groove reading motif; other site 363253003882 helix-hairpin-helix signature motif; other site 363253003883 substrate binding pocket [chemical binding]; other site 363253003884 active site 363253003885 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 363253003886 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 363253003887 metal-binding site [ion binding] 363253003888 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 363253003889 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 363253003890 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 363253003891 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 363253003892 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 363253003893 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 363253003894 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 363253003895 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 363253003896 Walker A/P-loop; other site 363253003897 ATP binding site [chemical binding]; other site 363253003898 Q-loop/lid; other site 363253003899 ABC transporter signature motif; other site 363253003900 Walker B; other site 363253003901 D-loop; other site 363253003902 H-loop/switch region; other site 363253003903 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 363253003904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253003905 S-adenosylmethionine binding site [chemical binding]; other site 363253003906 Preprotein translocase SecG subunit; Region: SecG; pfam03840 363253003907 triosephosphate isomerase; Provisional; Region: PRK14565 363253003908 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 363253003909 substrate binding site [chemical binding]; other site 363253003910 dimer interface [polypeptide binding]; other site 363253003911 catalytic triad [active] 363253003912 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 363253003913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 363253003914 Coenzyme A binding pocket [chemical binding]; other site 363253003915 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 363253003916 nudix motif; other site 363253003917 rod shape-determining protein MreB; Provisional; Region: PRK13930 363253003918 MreB and similar proteins; Region: MreB_like; cd10225 363253003919 nucleotide binding site [chemical binding]; other site 363253003920 Mg binding site [ion binding]; other site 363253003921 putative protofilament interaction site [polypeptide binding]; other site 363253003922 RodZ interaction site [polypeptide binding]; other site 363253003923 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 363253003924 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 363253003925 GAF domain; Region: GAF; pfam01590 363253003926 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 363253003927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003928 active site 363253003929 phosphorylation site [posttranslational modification] 363253003930 intermolecular recognition site; other site 363253003931 CheB methylesterase; Region: CheB_methylest; pfam01339 363253003932 HEAT repeats; Region: HEAT_2; pfam13646 363253003933 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 363253003934 protein binding surface [polypeptide binding]; other site 363253003935 HEAT repeats; Region: HEAT_2; pfam13646 363253003936 HEAT repeats; Region: HEAT_2; pfam13646 363253003937 HEAT repeats; Region: HEAT_2; pfam13646 363253003938 HEAT repeats; Region: HEAT_2; pfam13646 363253003939 HEAT repeats; Region: HEAT_2; pfam13646 363253003940 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 363253003941 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 363253003942 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 363253003943 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 363253003944 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253003945 P-loop; other site 363253003946 Magnesium ion binding site [ion binding]; other site 363253003947 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253003948 Magnesium ion binding site [ion binding]; other site 363253003949 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 363253003950 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 363253003951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 363253003952 active site 363253003953 phosphorylation site [posttranslational modification] 363253003954 intermolecular recognition site; other site 363253003955 dimerization interface [polypeptide binding]; other site 363253003956 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 363253003957 putative binding surface; other site 363253003958 active site 363253003959 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 363253003960 putative binding surface; other site 363253003961 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 363253003962 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 363253003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 363253003964 ATP binding site [chemical binding]; other site 363253003965 Mg2+ binding site [ion binding]; other site 363253003966 G-X-G motif; other site 363253003967 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 363253003968 HAMP domain; Region: HAMP; pfam00672 363253003969 dimerization interface [polypeptide binding]; other site 363253003970 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 363253003971 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 363253003972 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 363253003973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253003974 Walker A motif; other site 363253003975 ATP binding site [chemical binding]; other site 363253003976 Walker B motif; other site 363253003977 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 363253003978 HrpJ-like domain; Region: HrpJ; pfam07201 363253003979 TyeA; Region: TyeA; pfam09059 363253003980 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 363253003981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 363253003982 binding surface 363253003983 TPR motif; other site 363253003984 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 363253003985 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 363253003986 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 363253003987 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 363253003988 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 363253003989 FHA domain; Region: FHA; pfam00498 363253003990 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 363253003991 type III secretion system protein; Reviewed; Region: PRK06937 363253003992 Flagellar assembly protein FliH; Region: FliH; pfam02108 363253003993 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 363253003994 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 363253003995 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 363253003996 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 363253003997 anti sigma factor interaction site; other site 363253003998 regulatory phosphorylation site [posttranslational modification]; other site 363253003999 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 363253004000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 363253004001 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 363253004002 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 363253004003 N-acetyl-D-glucosamine binding site [chemical binding]; other site 363253004004 catalytic residue [active] 363253004005 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 363253004006 putative CheA interaction surface; other site 363253004007 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 363253004008 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 363253004009 active site 363253004010 metal binding site [ion binding]; metal-binding site 363253004011 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 363253004012 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 363253004013 Mechanosensitive ion channel; Region: MS_channel; pfam00924 363253004014 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 363253004015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 363253004016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 363253004017 catalytic residue [active] 363253004018 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 363253004019 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 363253004020 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 363253004021 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 363253004022 FMN binding site [chemical binding]; other site 363253004023 dimer interface [polypeptide binding]; other site 363253004024 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 363253004025 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 363253004026 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 363253004027 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 363253004028 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 363253004029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 363253004030 Walker A/P-loop; other site 363253004031 ATP binding site [chemical binding]; other site 363253004032 Q-loop/lid; other site 363253004033 ABC transporter signature motif; other site 363253004034 Walker B; other site 363253004035 D-loop; other site 363253004036 H-loop/switch region; other site 363253004037 BioY family; Region: BioY; pfam02632 363253004038 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 363253004039 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 363253004040 motif 1; other site 363253004041 active site 363253004042 motif 2; other site 363253004043 motif 3; other site 363253004044 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 363253004045 DHHA1 domain; Region: DHHA1; pfam02272 363253004046 recombinase A; Provisional; Region: recA; PRK09354 363253004047 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 363253004048 hexamer interface [polypeptide binding]; other site 363253004049 Walker A motif; other site 363253004050 ATP binding site [chemical binding]; other site 363253004051 Walker B motif; other site 363253004052 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 363253004053 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 363253004054 HIGH motif; other site 363253004055 active site 363253004056 KMSKS motif; other site 363253004057 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 363253004058 tRNA binding surface [nucleotide binding]; other site 363253004059 anticodon binding site; other site 363253004060 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 363253004061 dimer interface [polypeptide binding]; other site 363253004062 putative tRNA-binding site [nucleotide binding]; other site 363253004063 PSP1 C-terminal conserved region; Region: PSP1; cl00770 363253004064 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 363253004065 RuvA N terminal domain; Region: RuvA_N; pfam01330 363253004066 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 363253004067 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 363253004068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 363253004069 Walker A motif; other site 363253004070 ATP binding site [chemical binding]; other site 363253004071 Walker B motif; other site 363253004072 arginine finger; other site 363253004073 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 363253004074 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 363253004075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 363253004076 active site 363253004077 catalytic residues [active] 363253004078 DNA binding site [nucleotide binding] 363253004079 Int/Topo IB signature motif; other site 363253004080 Uncharacterized conserved protein [Function unknown]; Region: COG3347 363253004081 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 363253004082 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 363253004083 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 363253004084 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 363253004085 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 363253004086 active site 363253004087 Substrate binding site; other site 363253004088 Mg++ binding site; other site 363253004089 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 363253004090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 363253004091 active site 363253004092 motif I; other site 363253004093 motif II; other site 363253004094 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 363253004095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 363253004096 active site 363253004097 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253004098 Methyltransferase domain; Region: Methyltransf_12; pfam08242 363253004099 S-adenosylmethionine binding site [chemical binding]; other site 363253004100 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253004101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004102 S-adenosylmethionine binding site [chemical binding]; other site 363253004103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 363253004104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004105 S-adenosylmethionine binding site [chemical binding]; other site 363253004106 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253004107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004108 S-adenosylmethionine binding site [chemical binding]; other site 363253004109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253004110 Radical SAM superfamily; Region: Radical_SAM; pfam04055 363253004111 FeS/SAM binding site; other site 363253004112 Methyltransferase domain; Region: Methyltransf_23; pfam13489 363253004113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004114 S-adenosylmethionine binding site [chemical binding]; other site 363253004115 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 363253004116 B12 binding domain; Region: B12-binding; pfam02310 363253004117 B12 binding site [chemical binding]; other site 363253004118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253004119 FeS/SAM binding site; other site 363253004120 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 363253004121 dimer interface [polypeptide binding]; other site 363253004122 active site 363253004123 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 363253004124 DXD motif; other site 363253004125 Putative Catalytic site; other site 363253004126 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 363253004127 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 363253004128 NAD binding site [chemical binding]; other site 363253004129 homodimer interface [polypeptide binding]; other site 363253004130 active site 363253004131 substrate binding site [chemical binding]; other site 363253004132 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 363253004133 Ligand binding site; other site 363253004134 Putative Catalytic site; other site 363253004135 DXD motif; other site 363253004136 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 363253004137 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 363253004138 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 363253004139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 363253004140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004141 P-loop; other site 363253004142 Magnesium ion binding site [ion binding]; other site 363253004143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004144 Magnesium ion binding site [ion binding]; other site 363253004145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 363253004146 Predicted transcriptional regulator [Transcription]; Region: COG3905 363253004147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 363253004148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 363253004149 non-specific DNA binding site [nucleotide binding]; other site 363253004150 salt bridge; other site 363253004151 sequence-specific DNA binding site [nucleotide binding]; other site 363253004152 Autotransporter beta-domain; Region: Autotransporter; pfam03797 363253004153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 363253004154 Zn2+ binding site [ion binding]; other site 363253004155 Mg2+ binding site [ion binding]; other site 363253004156 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004157 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 363253004158 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 363253004159 active site 363253004160 dimer interface [polypeptide binding]; other site 363253004161 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 363253004162 Ligand Binding Site [chemical binding]; other site 363253004163 Molecular Tunnel; other site 363253004164 Catalytic domain of a putative polysaccharide deacetylase WbmS from Bordetella bronchiseptica and similar proteins; Region: CE4_WbmS; cd10920 363253004165 active site 363253004166 Zn binding site [ion binding]; other site 363253004167 Methyltransferase domain; Region: Methyltransf_31; pfam13847 363253004168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004169 S-adenosylmethionine binding site [chemical binding]; other site 363253004170 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 363253004171 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 363253004172 inhibitor-cofactor binding pocket; inhibition site 363253004173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253004174 catalytic residue [active] 363253004175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253004176 Radical SAM superfamily; Region: Radical_SAM; pfam04055 363253004177 FeS/SAM binding site; other site 363253004178 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 363253004179 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 363253004180 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 363253004181 putative trimer interface [polypeptide binding]; other site 363253004182 putative CoA binding site [chemical binding]; other site 363253004183 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 363253004184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004185 S-adenosylmethionine binding site [chemical binding]; other site 363253004186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004187 S-adenosylmethionine binding site [chemical binding]; other site 363253004188 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 363253004189 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 363253004190 inhibitor-cofactor binding pocket; inhibition site 363253004191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253004192 catalytic residue [active] 363253004193 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 363253004194 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 363253004195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 363253004196 FeS/SAM binding site; other site 363253004197 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 363253004198 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 363253004199 Autotransporter beta-domain; Region: Autotransporter; pfam03797 363253004200 Phage integrase family; Region: Phage_integrase; pfam00589 363253004201 active site 363253004202 DNA binding site [nucleotide binding] 363253004203 Int/Topo IB signature motif; other site 363253004204 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 363253004205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004206 P-loop; other site 363253004207 Magnesium ion binding site [ion binding]; other site 363253004208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004209 Magnesium ion binding site [ion binding]; other site 363253004210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 363253004211 active site 363253004212 DNA binding site [nucleotide binding] 363253004213 Int/Topo IB signature motif; other site 363253004214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253004215 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253004216 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 363253004217 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 363253004218 ABC-2 type transporter; Region: ABC2_membrane; cl17235 363253004219 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 363253004220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 363253004221 active site 363253004222 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 363253004223 putative ligand binding site [chemical binding]; other site 363253004224 putative catalytic site [active] 363253004225 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 363253004226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253004227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 363253004228 S-adenosylmethionine binding site [chemical binding]; other site 363253004229 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 363253004230 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 363253004231 Substrate binding site; other site 363253004232 Mg++ binding site; other site 363253004233 metal-binding site 363253004234 Mg++ binding site; other site 363253004235 metal-binding site 363253004236 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 363253004237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 363253004238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 363253004239 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 363253004240 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 363253004241 classical (c) SDRs; Region: SDR_c; cd05233 363253004242 NAD(P) binding site [chemical binding]; other site 363253004243 active site 363253004244 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 363253004245 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 363253004246 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 363253004247 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 363253004248 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 363253004249 putative translaldolase; Provisional; Region: PRK12376 363253004250 catalytic residue [active] 363253004251 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 363253004252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 363253004253 active site 363253004254 motif I; other site 363253004255 motif II; other site 363253004256 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 363253004257 dimer interface [polypeptide binding]; other site 363253004258 active site 363253004259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 363253004260 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 363253004261 NAD binding site [chemical binding]; other site 363253004262 homodimer interface [polypeptide binding]; other site 363253004263 active site 363253004264 putative substrate binding site [chemical binding]; other site 363253004265 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 363253004266 Ligand binding site; other site 363253004267 Putative Catalytic site; other site 363253004268 DXD motif; other site 363253004269 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 363253004270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 363253004271 non-specific DNA binding site [nucleotide binding]; other site 363253004272 salt bridge; other site 363253004273 sequence-specific DNA binding site [nucleotide binding]; other site 363253004274 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 363253004275 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 363253004276 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 363253004277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 363253004278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 363253004279 catalytic residue [active] 363253004280 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004281 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 363253004282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 363253004283 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004284 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 363253004285 Autotransporter beta-domain; Region: Autotransporter; pfam03797 363253004286 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004287 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 363253004288 heterodimer interface [polypeptide binding]; other site 363253004289 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004290 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004291 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004292 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004293 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004294 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004295 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004296 Autotransporter beta-domain; Region: Autotransporter; cl17461 363253004297 Autotransporter beta-domain; Region: Autotransporter; cl17461 363253004298 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 363253004299 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004300 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004301 Autotransporter beta-domain; Region: Autotransporter; cl17461 363253004302 Autotransporter beta-domain; Region: Autotransporter; cl17461 363253004303 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004304 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 363253004305 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004306 P-loop; other site 363253004307 Magnesium ion binding site [ion binding]; other site 363253004308 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 363253004309 Magnesium ion binding site [ion binding]; other site 363253004310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 363253004311 DNA-binding site [nucleotide binding]; DNA binding site 363253004312 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004313 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 363253004314 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 363253004315 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 363253004316 Domain of unknown function (DUF1834); Region: DUF1834; pfam08873 363253004317 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 363253004318 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 363253004319 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 363253004320 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 363253004321 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 363253004322 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 363253004323 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 363253004324 homotrimer interaction site [polypeptide binding]; other site 363253004325 putative active site [active] 363253004326 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 363253004327 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 363253004328 NADP binding site [chemical binding]; other site 363253004329 active site 363253004330 putative substrate binding site [chemical binding]; other site 363253004331 replicative DNA helicase; Region: DnaB; TIGR00665 363253004332 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 363253004333 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 363253004334 Walker A motif; other site 363253004335 ATP binding site [chemical binding]; other site 363253004336 Walker B motif; other site 363253004337 DNA binding loops [nucleotide binding] 363253004338 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 363253004339 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 363253004340 NADP-binding site; other site 363253004341 homotetramer interface [polypeptide binding]; other site 363253004342 substrate binding site [chemical binding]; other site 363253004343 homodimer interface [polypeptide binding]; other site 363253004344 active site 363253004345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 363253004346 non-specific DNA binding site [nucleotide binding]; other site 363253004347 salt bridge; other site 363253004348 sequence-specific DNA binding site [nucleotide binding]; other site 363253004349 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 363253004350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 363253004351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 363253004352 active site 363253004353 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 363253004354 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 363253004355 Probable Catalytic site; other site 363253004356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 363253004357 Phage protein GP46; Region: GP46; cl01814 363253004358 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 363253004359 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 363253004360 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 363253004361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 363253004362 putative substrate translocation pore; other site 363253004363 POT family; Region: PTR2; cl17359 363253004364 Autotransporter beta-domain; Region: Autotransporter; smart00869 363253004365 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 363253004366 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 363253004367 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 363253004368 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 363253004369 putative trimer interface [polypeptide binding]; other site 363253004370 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 363253004371 putative CoA binding site [chemical binding]; other site 363253004372 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 363253004373 putative trimer interface [polypeptide binding]; other site 363253004374 putative active site [active] 363253004375 putative substrate binding site [chemical binding]; other site 363253004376 putative CoA binding site [chemical binding]; other site 363253004377 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 363253004378 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 363253004379 inhibitor-cofactor binding pocket; inhibition site 363253004380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 363253004381 catalytic residue [active] 363253004382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 363253004383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 363253004384 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 363253004385 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 363253004386 dimer interface [polypeptide binding]; other site 363253004387 putative CheW interface [polypeptide binding]; other site 363253004388 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 363253004389 Haem-binding domain; Region: Haem_bd; pfam14376 363253004390 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 363253004391 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 363253004392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 363253004393 dimerization interface [polypeptide binding]; other site 363253004394 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 363253004395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 363253004396 dimer interface [polypeptide binding]; other site 363253004397 putative CheW interface [polypeptide binding]; other site 363253004398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440