-- dump date 20140619_130020 -- class Genbank::misc_feature -- table misc_feature_note -- id note 661367000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 661367000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 661367000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000004 Walker A motif; other site 661367000005 ATP binding site [chemical binding]; other site 661367000006 Walker B motif; other site 661367000007 arginine finger; other site 661367000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 661367000009 DnaA box-binding interface [nucleotide binding]; other site 661367000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 661367000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 661367000012 putative DNA binding surface [nucleotide binding]; other site 661367000013 dimer interface [polypeptide binding]; other site 661367000014 beta-clamp/clamp loader binding surface; other site 661367000015 beta-clamp/translesion DNA polymerase binding surface; other site 661367000016 recombination protein F; Reviewed; Region: recF; PRK00064 661367000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367000018 Walker A/P-loop; other site 661367000019 ATP binding site [chemical binding]; other site 661367000020 Q-loop/lid; other site 661367000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367000022 ABC transporter signature motif; other site 661367000023 Walker B; other site 661367000024 D-loop; other site 661367000025 H-loop/switch region; other site 661367000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 661367000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367000028 ATP binding site [chemical binding]; other site 661367000029 Mg2+ binding site [ion binding]; other site 661367000030 G-X-G motif; other site 661367000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 661367000032 anchoring element; other site 661367000033 dimer interface [polypeptide binding]; other site 661367000034 ATP binding site [chemical binding]; other site 661367000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 661367000036 active site 661367000037 putative metal-binding site [ion binding]; other site 661367000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 661367000039 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 661367000040 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 661367000041 active site 661367000042 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 661367000043 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 661367000044 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 661367000045 agmatine deiminase; Region: agmatine_aguA; TIGR03380 661367000046 arginine decarboxylase; Provisional; Region: PRK05354 661367000047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 661367000048 dimer interface [polypeptide binding]; other site 661367000049 active site 661367000050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367000051 catalytic residues [active] 661367000052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 661367000053 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 661367000054 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 661367000055 putative active site; other site 661367000056 catalytic triad [active] 661367000057 putative dimer interface [polypeptide binding]; other site 661367000058 bacterial Hfq-like; Region: Hfq; cd01716 661367000059 hexamer interface [polypeptide binding]; other site 661367000060 Sm1 motif; other site 661367000061 RNA binding site [nucleotide binding]; other site 661367000062 Sm2 motif; other site 661367000063 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 661367000064 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 661367000065 HflX GTPase family; Region: HflX; cd01878 661367000066 G1 box; other site 661367000067 GTP/Mg2+ binding site [chemical binding]; other site 661367000068 Switch I region; other site 661367000069 G2 box; other site 661367000070 G3 box; other site 661367000071 Switch II region; other site 661367000072 G4 box; other site 661367000073 G5 box; other site 661367000074 Phosphotransferase enzyme family; Region: APH; pfam01636 661367000075 thymidine kinase; Provisional; Region: PRK04296 661367000076 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 661367000077 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 661367000078 catalytic residues [active] 661367000079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367000080 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 661367000081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367000082 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367000083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367000084 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367000085 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 661367000086 Transposase domain (DUF772); Region: DUF772; pfam05598 661367000087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367000088 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 661367000089 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 661367000090 serine/threonine protein kinase; Provisional; Region: PRK11768 661367000091 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 661367000092 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 661367000093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367000094 ATP binding site [chemical binding]; other site 661367000095 putative Mg++ binding site [ion binding]; other site 661367000096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367000097 nucleotide binding region [chemical binding]; other site 661367000098 ATP-binding site [chemical binding]; other site 661367000099 Helicase associated domain (HA2); Region: HA2; pfam04408 661367000100 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 661367000101 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367000102 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000103 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000104 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000105 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367000107 active site 661367000108 ATP binding site [chemical binding]; other site 661367000109 substrate binding site [chemical binding]; other site 661367000110 activation loop (A-loop); other site 661367000111 Pirin-related protein [General function prediction only]; Region: COG1741 661367000112 Pirin; Region: Pirin; pfam02678 661367000113 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 661367000114 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 661367000115 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 661367000116 Serine carboxypeptidase S28; Region: Peptidase_S28; pfam05577 661367000117 Sporulation related domain; Region: SPOR; pfam05036 661367000118 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 661367000119 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 661367000120 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 661367000121 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 661367000122 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 661367000123 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 661367000124 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367000125 active site 661367000126 Zn binding site [ion binding]; other site 661367000127 hypothetical protein; Provisional; Region: PRK05255 661367000128 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 661367000129 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 661367000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367000131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000132 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 661367000133 active site 661367000134 Protein of unknown function (DUF962); Region: DUF962; cl01879 661367000135 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 661367000136 amino acid transporter; Region: 2A0306; TIGR00909 661367000137 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 661367000138 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 661367000139 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 661367000140 diiron binding motif [ion binding]; other site 661367000141 acetylornithine aminotransferase; Provisional; Region: PRK02627 661367000142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367000143 inhibitor-cofactor binding pocket; inhibition site 661367000144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367000145 catalytic residue [active] 661367000146 superoxide dismutase; Provisional; Region: PRK10543 661367000147 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 661367000148 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 661367000149 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 661367000150 putative GSH binding site [chemical binding]; other site 661367000151 catalytic residues [active] 661367000152 peroxidase; Provisional; Region: PRK15000 661367000153 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 661367000154 dimer interface [polypeptide binding]; other site 661367000155 decamer (pentamer of dimers) interface [polypeptide binding]; other site 661367000156 catalytic triad [active] 661367000157 peroxidatic and resolving cysteines [active] 661367000158 ribonuclease T; Provisional; Region: PRK05168 661367000159 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 661367000160 active site 661367000161 catalytic site [active] 661367000162 substrate binding site [chemical binding]; other site 661367000163 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 661367000164 active site 661367000165 substrate binding pocket [chemical binding]; other site 661367000166 dimer interface [polypeptide binding]; other site 661367000167 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000168 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000169 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000170 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 661367000171 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 661367000172 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 661367000173 dimer interface [polypeptide binding]; other site 661367000174 active site residues [active] 661367000175 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 661367000176 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 661367000177 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 661367000178 Cupin-like domain; Region: Cupin_8; pfam13621 661367000179 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 661367000180 trimer interface [polypeptide binding]; other site 661367000181 active site 661367000182 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367000183 IHF dimer interface [polypeptide binding]; other site 661367000184 IHF - DNA interface [nucleotide binding]; other site 661367000185 Histone methylation protein DOT1; Region: DOT1; pfam08123 661367000186 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 661367000187 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 661367000188 dimer interface [polypeptide binding]; other site 661367000189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367000190 catalytic residue [active] 661367000191 fumarate hydratase; Reviewed; Region: fumC; PRK00485 661367000192 Class II fumarases; Region: Fumarase_classII; cd01362 661367000193 active site 661367000194 tetramer interface [polypeptide binding]; other site 661367000195 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 661367000196 RNA methyltransferase, RsmE family; Region: TIGR00046 661367000197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 661367000198 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 661367000199 catalytic residues [active] 661367000200 transcription termination factor Rho; Provisional; Region: rho; PRK09376 661367000201 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 661367000202 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 661367000203 RNA binding site [nucleotide binding]; other site 661367000204 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 661367000205 multimer interface [polypeptide binding]; other site 661367000206 Walker A motif; other site 661367000207 ATP binding site [chemical binding]; other site 661367000208 Walker B motif; other site 661367000209 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 661367000210 FMN reductase; Validated; Region: fre; PRK08051 661367000211 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 661367000212 FAD binding pocket [chemical binding]; other site 661367000213 FAD binding motif [chemical binding]; other site 661367000214 phosphate binding motif [ion binding]; other site 661367000215 beta-alpha-beta structure motif; other site 661367000216 NAD binding pocket [chemical binding]; other site 661367000217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000218 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000219 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 661367000220 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 661367000221 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 661367000222 PAS domain S-box; Region: sensory_box; TIGR00229 661367000223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367000224 putative active site [active] 661367000225 heme pocket [chemical binding]; other site 661367000226 GAF domain; Region: GAF_3; pfam13492 661367000227 GAF domain; Region: GAF_2; pfam13185 661367000228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367000229 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367000230 metal binding site [ion binding]; metal-binding site 661367000231 active site 661367000232 I-site; other site 661367000233 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 661367000234 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 661367000235 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367000236 DNA-binding site [nucleotide binding]; DNA binding site 661367000237 RNA-binding motif; other site 661367000238 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 661367000239 Haemolysin-III related; Region: HlyIII; cl03831 661367000240 S4 domain; Region: S4_2; pfam13275 661367000241 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 661367000242 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 661367000243 active site 661367000244 Zn binding site [ion binding]; other site 661367000245 DDE domain; Region: DDE_Tnp_IS240; pfam13610 661367000246 Integrase core domain; Region: rve; pfam00665 661367000247 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 661367000248 active site 661367000249 catalytic residues [active] 661367000250 DNA binding site [nucleotide binding] 661367000251 Int/Topo IB signature motif; other site 661367000252 Transposase domain (DUF772); Region: DUF772; pfam05598 661367000253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367000254 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 661367000255 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 661367000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367000257 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 661367000258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367000259 SnoaL-like domain; Region: SnoaL_2; pfam12680 661367000260 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000261 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000262 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000263 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367000264 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 661367000265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367000266 ATP binding site [chemical binding]; other site 661367000267 Mg2+ binding site [ion binding]; other site 661367000268 G-X-G motif; other site 661367000269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367000270 Ligand Binding Site [chemical binding]; other site 661367000271 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 661367000272 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 661367000273 putative active site [active] 661367000274 putative metal binding site [ion binding]; other site 661367000275 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 661367000276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367000277 active site 661367000278 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 661367000279 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 661367000280 tetramerization interface [polypeptide binding]; other site 661367000281 active site 661367000282 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 661367000283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000284 S-adenosylmethionine binding site [chemical binding]; other site 661367000285 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 661367000286 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 661367000287 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 661367000288 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 661367000289 active site 661367000290 metal binding site [ion binding]; metal-binding site 661367000291 Outer membrane efflux protein; Region: OEP; pfam02321 661367000292 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367000293 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367000294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 661367000295 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 661367000296 Walker A/P-loop; other site 661367000297 ATP binding site [chemical binding]; other site 661367000298 Q-loop/lid; other site 661367000299 ABC transporter signature motif; other site 661367000300 Walker B; other site 661367000301 D-loop; other site 661367000302 H-loop/switch region; other site 661367000303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367000304 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 661367000305 FtsX-like permease family; Region: FtsX; pfam02687 661367000306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367000307 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 661367000308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367000309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367000310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367000311 dimerization interface [polypeptide binding]; other site 661367000312 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 661367000313 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 661367000314 Transglycosylase SLT domain; Region: SLT_2; pfam13406 661367000315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 661367000316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367000317 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 661367000318 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 661367000319 methionine sulfoxide reductase A; Provisional; Region: PRK14054 661367000320 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 661367000321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367000322 Coenzyme A binding pocket [chemical binding]; other site 661367000323 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 661367000324 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 661367000325 ABC1 family; Region: ABC1; pfam03109 661367000326 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 661367000327 active site 661367000328 ATP binding site [chemical binding]; other site 661367000329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 661367000330 SCP-2 sterol transfer family; Region: SCP2; pfam02036 661367000331 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 661367000332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000333 S-adenosylmethionine binding site [chemical binding]; other site 661367000334 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 661367000335 Predicted transcriptional regulator [Transcription]; Region: COG3655 661367000336 salt bridge; other site 661367000337 non-specific DNA binding site [nucleotide binding]; other site 661367000338 sequence-specific DNA binding site [nucleotide binding]; other site 661367000339 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 661367000340 LysE type translocator; Region: LysE; cl00565 661367000341 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 661367000342 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 661367000343 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 661367000344 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 661367000345 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00139 661367000346 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 661367000347 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 661367000348 Cytochrome c; Region: Cytochrom_C; pfam00034 661367000349 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 661367000350 Subunit I/III interface [polypeptide binding]; other site 661367000351 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 661367000352 D-pathway; other site 661367000353 Subunit I/VIIc interface [polypeptide binding]; other site 661367000354 Subunit I/IV interface [polypeptide binding]; other site 661367000355 Subunit I/II interface [polypeptide binding]; other site 661367000356 Low-spin heme (heme a) binding site [chemical binding]; other site 661367000357 Subunit I/VIIa interface [polypeptide binding]; other site 661367000358 Subunit I/VIa interface [polypeptide binding]; other site 661367000359 Dimer interface; other site 661367000360 Putative water exit pathway; other site 661367000361 Binuclear center (heme a3/CuB) [ion binding]; other site 661367000362 K-pathway; other site 661367000363 Subunit I/Vb interface [polypeptide binding]; other site 661367000364 Putative proton exit pathway; other site 661367000365 Subunit I/VIb interface; other site 661367000366 Subunit I/VIc interface [polypeptide binding]; other site 661367000367 Electron transfer pathway; other site 661367000368 Subunit I/VIIIb interface [polypeptide binding]; other site 661367000369 Subunit I/VIIb interface [polypeptide binding]; other site 661367000370 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 661367000371 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 661367000372 Subunit III/VIIa interface [polypeptide binding]; other site 661367000373 Phospholipid binding site [chemical binding]; other site 661367000374 Subunit I/III interface [polypeptide binding]; other site 661367000375 Subunit III/VIb interface [polypeptide binding]; other site 661367000376 Subunit III/VIa interface; other site 661367000377 Subunit III/Vb interface [polypeptide binding]; other site 661367000378 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 661367000379 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 661367000380 active site 661367000381 catalytic residues [active] 661367000382 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 661367000383 ParB-like nuclease domain; Region: ParBc; pfam02195 661367000384 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 661367000385 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367000386 P-loop; other site 661367000387 Magnesium ion binding site [ion binding]; other site 661367000388 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367000389 Magnesium ion binding site [ion binding]; other site 661367000390 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 661367000391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000392 S-adenosylmethionine binding site [chemical binding]; other site 661367000393 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 661367000394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367000395 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 661367000396 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 661367000397 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367000398 Oxygen tolerance; Region: BatD; pfam13584 661367000399 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 661367000400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367000401 binding surface 661367000402 TPR motif; other site 661367000403 TPR repeat; Region: TPR_11; pfam13414 661367000404 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 661367000405 metal ion-dependent adhesion site (MIDAS); other site 661367000406 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 661367000407 metal ion-dependent adhesion site (MIDAS); other site 661367000408 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 661367000409 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 661367000410 Protein of unknown function DUF58; Region: DUF58; pfam01882 661367000411 MoxR-like ATPases [General function prediction only]; Region: COG0714 661367000412 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 661367000413 Walker A motif; other site 661367000414 ATP binding site [chemical binding]; other site 661367000415 Walker B motif; other site 661367000416 arginine finger; other site 661367000417 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 661367000418 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 661367000419 FMN binding site [chemical binding]; other site 661367000420 active site 661367000421 catalytic residues [active] 661367000422 substrate binding site [chemical binding]; other site 661367000423 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367000424 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 661367000425 pteridine reductase; Provisional; Region: PRK09135 661367000426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000427 NAD(P) binding site [chemical binding]; other site 661367000428 active site 661367000429 Uncharacterized conserved protein [Function unknown]; Region: COG1565 661367000430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367000431 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 661367000432 primosome assembly protein PriA; Validated; Region: PRK05580 661367000433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367000434 ATP binding site [chemical binding]; other site 661367000435 putative Mg++ binding site [ion binding]; other site 661367000436 helicase superfamily c-terminal domain; Region: HELICc; smart00490 661367000437 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 661367000438 active site 661367000439 Autotransporter beta-domain; Region: Autotransporter; cl17461 661367000440 CHASE2 domain; Region: CHASE2; pfam05226 661367000441 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367000442 cyclase homology domain; Region: CHD; cd07302 661367000443 nucleotidyl binding site; other site 661367000444 metal binding site [ion binding]; metal-binding site 661367000445 dimer interface [polypeptide binding]; other site 661367000446 FecR protein; Region: FecR; pfam04773 661367000447 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 661367000448 thymidylate synthase; Reviewed; Region: thyA; PRK01827 661367000449 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 661367000450 dimerization interface [polypeptide binding]; other site 661367000451 active site 661367000452 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 661367000453 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 661367000454 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 661367000455 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 661367000456 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 661367000457 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 661367000458 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 661367000459 putative active site [active] 661367000460 Ap4A binding site [chemical binding]; other site 661367000461 nudix motif; other site 661367000462 putative metal binding site [ion binding]; other site 661367000463 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 661367000464 active site 661367000465 homodimer interface [polypeptide binding]; other site 661367000466 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 661367000467 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 661367000468 Substrate binding site; other site 661367000469 Mg++ binding site; other site 661367000470 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 661367000471 active site 661367000472 substrate binding site [chemical binding]; other site 661367000473 CoA binding site [chemical binding]; other site 661367000474 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 661367000475 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 661367000476 endonuclease III; Provisional; Region: PRK10702 661367000477 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367000478 minor groove reading motif; other site 661367000479 helix-hairpin-helix signature motif; other site 661367000480 substrate binding pocket [chemical binding]; other site 661367000481 active site 661367000482 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 661367000483 ferredoxin; Provisional; Region: PRK08764 661367000484 Putative Fe-S cluster; Region: FeS; pfam04060 661367000485 4Fe-4S binding domain; Region: Fer4; pfam00037 661367000486 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 661367000487 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 661367000488 active site 661367000489 HIGH motif; other site 661367000490 KMSKS motif; other site 661367000491 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 661367000492 anticodon binding site; other site 661367000493 tRNA binding surface [nucleotide binding]; other site 661367000494 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 661367000495 Ligand Binding Site [chemical binding]; other site 661367000496 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 661367000497 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 661367000498 Substrate binding site; other site 661367000499 Cupin domain; Region: Cupin_2; cl17218 661367000500 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 661367000501 CAS motifs; other site 661367000502 active site 661367000503 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 661367000504 Esterase/lipase [General function prediction only]; Region: COG1647 661367000505 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 661367000506 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 661367000507 active site 661367000508 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 661367000509 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 661367000510 putative active site [active] 661367000511 PhoH-like protein; Region: PhoH; pfam02562 661367000512 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 661367000513 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 661367000514 catalytic triad [active] 661367000515 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 661367000516 SmpB-tmRNA interface; other site 661367000517 hypothetical protein; Validated; Region: PRK01415 661367000518 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 661367000519 active site residue [active] 661367000520 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367000521 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367000522 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367000523 active site 661367000524 oxyanion hole [active] 661367000525 catalytic triad [active] 661367000526 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 661367000527 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 661367000528 glutaminase active site [active] 661367000529 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 661367000530 dimer interface [polypeptide binding]; other site 661367000531 active site 661367000532 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 661367000533 dimer interface [polypeptide binding]; other site 661367000534 active site 661367000535 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 661367000536 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 661367000537 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 661367000538 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 661367000539 RNA binding site [nucleotide binding]; other site 661367000540 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 661367000541 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 661367000542 Lumazine binding domain; Region: Lum_binding; pfam00677 661367000543 Lumazine binding domain; Region: Lum_binding; pfam00677 661367000544 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 661367000545 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 661367000546 putative ion selectivity filter; other site 661367000547 putative pore gating glutamate residue; other site 661367000548 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 661367000549 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 661367000550 active site 661367000551 homodimer interface [polypeptide binding]; other site 661367000552 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 661367000553 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 661367000554 NAD binding site [chemical binding]; other site 661367000555 homotetramer interface [polypeptide binding]; other site 661367000556 homodimer interface [polypeptide binding]; other site 661367000557 substrate binding site [chemical binding]; other site 661367000558 active site 661367000559 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 661367000560 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 661367000561 substrate binding site; other site 661367000562 GtrA-like protein; Region: GtrA; pfam04138 661367000563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000564 S-adenosylmethionine binding site [chemical binding]; other site 661367000565 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 661367000566 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 661367000567 Ligand binding site; other site 661367000568 Putative Catalytic site; other site 661367000569 DXD motif; other site 661367000570 Membrane-associating domain; Region: MARVEL; pfam01284 661367000571 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 661367000572 Methyltransferase domain; Region: Methyltransf_23; pfam13489 661367000573 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 661367000574 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367000575 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 661367000576 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367000577 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 661367000578 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 661367000579 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 661367000580 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 661367000581 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 661367000582 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 661367000583 putative active site [active] 661367000584 putative metal binding site [ion binding]; other site 661367000585 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367000586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 661367000587 active site 661367000588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367000589 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367000590 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 661367000591 putative glycosyl transferase; Provisional; Region: PRK10307 661367000592 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 661367000593 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 661367000594 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 661367000595 NADP binding site [chemical binding]; other site 661367000596 active site 661367000597 putative substrate binding site [chemical binding]; other site 661367000598 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 661367000599 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 661367000600 NAD(P) binding site [chemical binding]; other site 661367000601 homodimer interface [polypeptide binding]; other site 661367000602 substrate binding site [chemical binding]; other site 661367000603 active site 661367000604 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 661367000605 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367000606 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 661367000607 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 661367000608 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 661367000609 homotetramer interface [polypeptide binding]; other site 661367000610 FMN binding site [chemical binding]; other site 661367000611 homodimer contacts [polypeptide binding]; other site 661367000612 putative active site [active] 661367000613 putative substrate binding site [chemical binding]; other site 661367000614 Predicted flavoprotein [General function prediction only]; Region: COG0431 661367000615 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 661367000616 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367000617 DNA-binding site [nucleotide binding]; DNA binding site 661367000618 RNA-binding motif; other site 661367000619 putative transporter; Provisional; Region: PRK10504 661367000620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367000621 putative substrate translocation pore; other site 661367000622 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 661367000623 Part of AAA domain; Region: AAA_19; pfam13245 661367000624 Family description; Region: UvrD_C_2; pfam13538 661367000625 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 661367000626 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 661367000627 dimerization interface [polypeptide binding]; other site 661367000628 domain crossover interface; other site 661367000629 redox-dependent activation switch; other site 661367000630 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000631 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367000632 Caleosin related protein; Region: Caleosin; pfam05042 661367000633 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 661367000634 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 661367000635 G1 box; other site 661367000636 putative GEF interaction site [polypeptide binding]; other site 661367000637 GTP/Mg2+ binding site [chemical binding]; other site 661367000638 Switch I region; other site 661367000639 G2 box; other site 661367000640 G3 box; other site 661367000641 Switch II region; other site 661367000642 G4 box; other site 661367000643 G5 box; other site 661367000644 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 661367000645 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 661367000646 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 661367000647 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 661367000648 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 661367000649 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 661367000650 Walker A/P-loop; other site 661367000651 ATP binding site [chemical binding]; other site 661367000652 Q-loop/lid; other site 661367000653 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 661367000654 ABC transporter signature motif; other site 661367000655 Walker B; other site 661367000656 D-loop; other site 661367000657 H-loop/switch region; other site 661367000658 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 661367000659 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 661367000660 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 661367000661 Peptidase family M28; Region: Peptidase_M28; pfam04389 661367000662 metal binding site [ion binding]; metal-binding site 661367000663 SpoVR family protein; Provisional; Region: PRK11767 661367000664 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 661367000665 hypothetical protein; Provisional; Region: PRK05325 661367000666 PrkA family serine protein kinase; Provisional; Region: PRK15455 661367000667 AAA ATPase domain; Region: AAA_16; pfam13191 661367000668 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 661367000669 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 661367000670 aminopeptidase N; Provisional; Region: pepN; PRK14015 661367000671 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 661367000672 active site 661367000673 Zn binding site [ion binding]; other site 661367000674 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 661367000675 homodimer interface [polypeptide binding]; other site 661367000676 active site 661367000677 putative chemical substrate binding site [chemical binding]; other site 661367000678 metal binding site [ion binding]; metal-binding site 661367000679 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367000680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367000681 ligand binding site [chemical binding]; other site 661367000682 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 661367000683 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 661367000684 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 661367000685 shikimate binding site; other site 661367000686 NAD(P) binding site [chemical binding]; other site 661367000687 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367000688 nucleophile elbow; other site 661367000689 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 661367000690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367000691 putative substrate translocation pore; other site 661367000692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367000693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367000694 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367000695 substrate binding pocket [chemical binding]; other site 661367000696 membrane-bound complex binding site; other site 661367000697 hinge residues; other site 661367000698 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 661367000699 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 661367000700 Walker A motif; other site 661367000701 ATP binding site [chemical binding]; other site 661367000702 Walker B motif; other site 661367000703 arginine finger; other site 661367000704 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367000705 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 661367000706 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 661367000707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000708 S-adenosylmethionine binding site [chemical binding]; other site 661367000709 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 661367000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000711 Walker A motif; other site 661367000712 ATP binding site [chemical binding]; other site 661367000713 Walker B motif; other site 661367000714 arginine finger; other site 661367000715 Peptidase family M41; Region: Peptidase_M41; pfam01434 661367000716 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 661367000717 dihydropteroate synthase; Region: DHPS; TIGR01496 661367000718 substrate binding pocket [chemical binding]; other site 661367000719 dimer interface [polypeptide binding]; other site 661367000720 inhibitor binding site; inhibition site 661367000721 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 661367000722 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 661367000723 active site 661367000724 substrate binding site [chemical binding]; other site 661367000725 metal binding site [ion binding]; metal-binding site 661367000726 triosephosphate isomerase; Provisional; Region: PRK14567 661367000727 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 661367000728 substrate binding site [chemical binding]; other site 661367000729 dimer interface [polypeptide binding]; other site 661367000730 catalytic triad [active] 661367000731 Preprotein translocase SecG subunit; Region: SecG; pfam03840 661367000732 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 661367000733 NADH dehydrogenase subunit B; Validated; Region: PRK06411 661367000734 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 661367000735 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 661367000736 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 661367000737 NADH dehydrogenase subunit D; Validated; Region: PRK06075 661367000738 NADH dehydrogenase subunit E; Validated; Region: PRK07539 661367000739 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 661367000740 putative dimer interface [polypeptide binding]; other site 661367000741 [2Fe-2S] cluster binding site [ion binding]; other site 661367000742 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 661367000743 SLBB domain; Region: SLBB; pfam10531 661367000744 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 661367000745 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 661367000746 NADH dehydrogenase subunit G; Validated; Region: PRK09129 661367000747 catalytic loop [active] 661367000748 iron binding site [ion binding]; other site 661367000749 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 661367000750 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 661367000751 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 661367000752 molybdopterin cofactor binding site; other site 661367000753 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 661367000754 4Fe-4S binding domain; Region: Fer4; cl02805 661367000755 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 661367000756 4Fe-4S binding domain; Region: Fer4; pfam00037 661367000757 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 661367000758 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 661367000759 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 661367000760 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 661367000761 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 661367000762 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 661367000763 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 661367000764 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 661367000765 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 661367000766 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 661367000767 ribosome maturation protein RimP; Reviewed; Region: PRK00092 661367000768 Sm and related proteins; Region: Sm_like; cl00259 661367000769 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 661367000770 putative oligomer interface [polypeptide binding]; other site 661367000771 putative RNA binding site [nucleotide binding]; other site 661367000772 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 661367000773 NusA N-terminal domain; Region: NusA_N; pfam08529 661367000774 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 661367000775 RNA binding site [nucleotide binding]; other site 661367000776 homodimer interface [polypeptide binding]; other site 661367000777 NusA-like KH domain; Region: KH_5; pfam13184 661367000778 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 661367000779 G-X-X-G motif; other site 661367000780 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 661367000781 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 661367000782 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 661367000783 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 661367000784 translation initiation factor IF-2; Validated; Region: infB; PRK05306 661367000785 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 661367000786 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 661367000787 G1 box; other site 661367000788 putative GEF interaction site [polypeptide binding]; other site 661367000789 GTP/Mg2+ binding site [chemical binding]; other site 661367000790 Switch I region; other site 661367000791 G2 box; other site 661367000792 G3 box; other site 661367000793 Switch II region; other site 661367000794 G4 box; other site 661367000795 G5 box; other site 661367000796 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 661367000797 Translation-initiation factor 2; Region: IF-2; pfam11987 661367000798 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 661367000799 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 661367000800 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 661367000801 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 661367000802 RNA binding site [nucleotide binding]; other site 661367000803 active site 661367000804 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 661367000805 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 661367000806 16S/18S rRNA binding site [nucleotide binding]; other site 661367000807 S13e-L30e interaction site [polypeptide binding]; other site 661367000808 25S rRNA binding site [nucleotide binding]; other site 661367000809 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 661367000810 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 661367000811 RNase E interface [polypeptide binding]; other site 661367000812 trimer interface [polypeptide binding]; other site 661367000813 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 661367000814 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 661367000815 RNase E interface [polypeptide binding]; other site 661367000816 trimer interface [polypeptide binding]; other site 661367000817 active site 661367000818 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 661367000819 putative nucleic acid binding region [nucleotide binding]; other site 661367000820 G-X-X-G motif; other site 661367000821 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 661367000822 RNA binding site [nucleotide binding]; other site 661367000823 domain interface; other site 661367000824 GTP cyclohydrolase I; Provisional; Region: PLN03044 661367000825 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 661367000826 homodecamer interface [polypeptide binding]; other site 661367000827 active site 661367000828 putative catalytic site residues [active] 661367000829 zinc binding site [ion binding]; other site 661367000830 GTP-CH-I/GFRP interaction surface; other site 661367000831 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 661367000832 nucleotide binding site/active site [active] 661367000833 HIT family signature motif; other site 661367000834 catalytic residue [active] 661367000835 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 661367000836 dimer interface [polypeptide binding]; other site 661367000837 substrate binding site [chemical binding]; other site 661367000838 metal binding sites [ion binding]; metal-binding site 661367000839 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 661367000840 Domain of unknown function DUF21; Region: DUF21; pfam01595 661367000841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367000842 Transporter associated domain; Region: CorC_HlyC; smart01091 661367000843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367000844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367000845 active site 661367000846 dimerization interface [polypeptide binding]; other site 661367000847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367000848 DNA binding site [nucleotide binding] 661367000849 Protein of unknown function, DUF547; Region: DUF547; pfam04784 661367000850 recombination protein RecR; Reviewed; Region: recR; PRK00076 661367000851 RecR protein; Region: RecR; pfam02132 661367000852 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 661367000853 putative active site [active] 661367000854 putative metal-binding site [ion binding]; other site 661367000855 tetramer interface [polypeptide binding]; other site 661367000856 hypothetical protein; Validated; Region: PRK00153 661367000857 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 661367000858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000859 Walker A motif; other site 661367000860 ATP binding site [chemical binding]; other site 661367000861 Walker B motif; other site 661367000862 arginine finger; other site 661367000863 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 661367000864 GTPase RsgA; Reviewed; Region: PRK12288 661367000865 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 661367000866 RNA binding site [nucleotide binding]; other site 661367000867 homodimer interface [polypeptide binding]; other site 661367000868 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 661367000869 GTPase/Zn-binding domain interface [polypeptide binding]; other site 661367000870 GTP/Mg2+ binding site [chemical binding]; other site 661367000871 G4 box; other site 661367000872 G5 box; other site 661367000873 G1 box; other site 661367000874 Switch I region; other site 661367000875 G2 box; other site 661367000876 G3 box; other site 661367000877 Switch II region; other site 661367000878 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 661367000879 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367000880 active site 661367000881 NTP binding site [chemical binding]; other site 661367000882 metal binding triad [ion binding]; metal-binding site 661367000883 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367000884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367000885 Zn2+ binding site [ion binding]; other site 661367000886 Mg2+ binding site [ion binding]; other site 661367000887 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 661367000888 catalytic site [active] 661367000889 putative active site [active] 661367000890 putative substrate binding site [chemical binding]; other site 661367000891 dimer interface [polypeptide binding]; other site 661367000892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 661367000893 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 661367000894 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 661367000895 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 661367000896 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 661367000897 NAD binding site [chemical binding]; other site 661367000898 homotetramer interface [polypeptide binding]; other site 661367000899 homodimer interface [polypeptide binding]; other site 661367000900 substrate binding site [chemical binding]; other site 661367000901 active site 661367000902 V-type ATP synthase subunit B; Provisional; Region: PRK02118 661367000903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 661367000904 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 661367000905 Walker A motif homologous position; other site 661367000906 Walker B motif; other site 661367000907 V-type ATP synthase subunit D; Provisional; Region: PRK02195 661367000908 V-type ATP synthase subunit I; Validated; Region: PRK05771 661367000909 V-type ATP synthase subunit K; Provisional; Region: PRK09621 661367000910 V-type ATP synthase subunit E; Provisional; Region: PRK01558 661367000911 V-type ATP synthase subunit E; Provisional; Region: PRK01005 661367000912 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 661367000913 V-type ATP synthase subunit A; Provisional; Region: PRK04192 661367000914 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 661367000915 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 661367000916 Walker A motif/ATP binding site; other site 661367000917 Walker B motif; other site 661367000918 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 661367000919 HemY protein N-terminus; Region: HemY_N; pfam07219 661367000920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367000921 TPR motif; other site 661367000922 binding surface 661367000923 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 661367000924 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 661367000925 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 661367000926 active site 661367000927 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 661367000928 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 661367000929 domain interfaces; other site 661367000930 active site 661367000931 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 661367000932 Ras interaction site [polypeptide binding]; other site 661367000933 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 661367000934 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 661367000935 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 661367000936 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367000937 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 661367000938 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 661367000939 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 661367000940 substrate binding site [chemical binding]; other site 661367000941 Predicted membrane protein [Function unknown]; Region: COG2860 661367000942 UPF0126 domain; Region: UPF0126; pfam03458 661367000943 UPF0126 domain; Region: UPF0126; pfam03458 661367000944 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 661367000945 non-specific DNA binding site [nucleotide binding]; other site 661367000946 salt bridge; other site 661367000947 sequence-specific DNA binding site [nucleotide binding]; other site 661367000948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 661367000949 MarR family; Region: MarR; pfam01047 661367000950 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367000951 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367000952 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 661367000953 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 661367000954 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 661367000955 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 661367000956 active site 661367000957 dimer interface [polypeptide binding]; other site 661367000958 motif 1; other site 661367000959 motif 2; other site 661367000960 motif 3; other site 661367000961 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 661367000962 anticodon binding site; other site 661367000963 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 661367000964 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 661367000965 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 661367000966 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 661367000967 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 661367000968 23S rRNA binding site [nucleotide binding]; other site 661367000969 L21 binding site [polypeptide binding]; other site 661367000970 L13 binding site [polypeptide binding]; other site 661367000971 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 661367000972 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 661367000973 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 661367000974 dimer interface [polypeptide binding]; other site 661367000975 motif 1; other site 661367000976 active site 661367000977 motif 2; other site 661367000978 motif 3; other site 661367000979 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 661367000980 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 661367000981 putative tRNA-binding site [nucleotide binding]; other site 661367000982 B3/4 domain; Region: B3_4; pfam03483 661367000983 tRNA synthetase B5 domain; Region: B5; pfam03484 661367000984 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 661367000985 dimer interface [polypeptide binding]; other site 661367000986 motif 1; other site 661367000987 motif 3; other site 661367000988 motif 2; other site 661367000989 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 661367000990 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367000991 IHF dimer interface [polypeptide binding]; other site 661367000992 IHF - DNA interface [nucleotide binding]; other site 661367000993 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 661367000994 dimer interface [polypeptide binding]; other site 661367000995 [2Fe-2S] cluster binding site [ion binding]; other site 661367000996 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 661367000997 23S rRNA interface [nucleotide binding]; other site 661367000998 L3 interface [polypeptide binding]; other site 661367000999 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 661367001000 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 661367001001 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 661367001002 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 661367001003 [2Fe-2S] cluster binding site [ion binding]; other site 661367001004 cytochrome b; Validated; Region: CYTB; MTH00016 661367001005 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 661367001006 Qi binding site; other site 661367001007 intrachain domain interface; other site 661367001008 interchain domain interface [polypeptide binding]; other site 661367001009 heme bH binding site [chemical binding]; other site 661367001010 heme bL binding site [chemical binding]; other site 661367001011 Qo binding site; other site 661367001012 interchain domain interface [polypeptide binding]; other site 661367001013 intrachain domain interface; other site 661367001014 Qi binding site; other site 661367001015 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 661367001016 Qo binding site; other site 661367001017 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 661367001018 stringent starvation protein A; Provisional; Region: sspA; PRK09481 661367001019 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 661367001020 C-terminal domain interface [polypeptide binding]; other site 661367001021 putative GSH binding site (G-site) [chemical binding]; other site 661367001022 dimer interface [polypeptide binding]; other site 661367001023 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 661367001024 dimer interface [polypeptide binding]; other site 661367001025 N-terminal domain interface [polypeptide binding]; other site 661367001026 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 661367001027 putative carbohydrate kinase; Provisional; Region: PRK10565 661367001028 Uncharacterized conserved protein [Function unknown]; Region: COG0062 661367001029 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 661367001030 putative substrate binding site [chemical binding]; other site 661367001031 putative ATP binding site [chemical binding]; other site 661367001032 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 661367001033 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 661367001034 AMIN domain; Region: AMIN; pfam11741 661367001035 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 661367001036 active site 661367001037 metal binding site [ion binding]; metal-binding site 661367001038 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367001039 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 661367001040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367001041 ATP binding site [chemical binding]; other site 661367001042 Mg2+ binding site [ion binding]; other site 661367001043 G-X-G motif; other site 661367001044 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 661367001045 ATP binding site [chemical binding]; other site 661367001046 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 661367001047 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 661367001048 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 661367001049 Zinc-finger domain; Region: zf-CHCC; cl01821 661367001050 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 661367001051 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 661367001052 putative active site [active] 661367001053 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 661367001054 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 661367001055 metal-binding site [ion binding] 661367001056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367001057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367001058 motif II; other site 661367001059 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 661367001060 Phagosome trafficking protein DotA; Region: DotA; pfam11388 661367001061 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 661367001062 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 661367001063 active site 661367001064 catalytic residues [active] 661367001065 metal binding site [ion binding]; metal-binding site 661367001066 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 661367001067 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367001068 Walker A motif; other site 661367001069 ATP binding site [chemical binding]; other site 661367001070 Walker B motif; other site 661367001071 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 661367001072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001073 S-adenosylmethionine binding site [chemical binding]; other site 661367001074 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 661367001075 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 661367001076 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 661367001077 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 661367001078 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 661367001079 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 661367001080 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 661367001081 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 661367001082 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 661367001083 P loop; other site 661367001084 GTP binding site [chemical binding]; other site 661367001085 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 661367001086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367001087 Walker A/P-loop; other site 661367001088 ATP binding site [chemical binding]; other site 661367001089 Q-loop/lid; other site 661367001090 ABC transporter signature motif; other site 661367001091 Walker B; other site 661367001092 D-loop; other site 661367001093 H-loop/switch region; other site 661367001094 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 661367001095 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 661367001096 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 661367001097 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367001098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367001099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367001100 DNA binding residues [nucleotide binding] 661367001101 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 661367001102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367001103 Dienelactone hydrolase family; Region: DLH; pfam01738 661367001104 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 661367001105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001106 binding surface 661367001107 TPR motif; other site 661367001108 TPR repeat; Region: TPR_11; pfam13414 661367001109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001110 binding surface 661367001111 TPR repeat; Region: TPR_11; pfam13414 661367001112 TPR motif; other site 661367001113 TPR repeat; Region: TPR_11; pfam13414 661367001114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001115 binding surface 661367001116 TPR motif; other site 661367001117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 661367001118 TPR repeat; Region: TPR_11; pfam13414 661367001119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001120 binding surface 661367001121 TPR motif; other site 661367001122 TPR repeat; Region: TPR_11; pfam13414 661367001123 TPR repeat; Region: TPR_11; pfam13414 661367001124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001125 TPR motif; other site 661367001126 binding surface 661367001127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367001128 binding surface 661367001129 TPR motif; other site 661367001130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367001131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001132 NAD(P) binding site [chemical binding]; other site 661367001133 active site 661367001134 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 661367001135 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 661367001136 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 661367001137 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367001138 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 661367001139 DXD motif; other site 661367001140 pantoate--beta-alanine ligase; Region: panC; TIGR00018 661367001141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367001142 active site 661367001143 nucleotide binding site [chemical binding]; other site 661367001144 HIGH motif; other site 661367001145 KMSKS motif; other site 661367001146 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 661367001147 oligomerization interface [polypeptide binding]; other site 661367001148 active site 661367001149 metal binding site [ion binding]; metal-binding site 661367001150 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 661367001151 Predicted ATPase [General function prediction only]; Region: COG1485 661367001152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 661367001153 Walker A/P-loop; other site 661367001154 ATP binding site [chemical binding]; other site 661367001155 ABC transporter signature motif; other site 661367001156 Walker B; other site 661367001157 D-loop; other site 661367001158 H-loop/switch region; other site 661367001159 FeoA domain; Region: FeoA; pfam04023 661367001160 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 661367001161 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 661367001162 G1 box; other site 661367001163 GTP/Mg2+ binding site [chemical binding]; other site 661367001164 Switch I region; other site 661367001165 G2 box; other site 661367001166 G3 box; other site 661367001167 Switch II region; other site 661367001168 G4 box; other site 661367001169 G5 box; other site 661367001170 Nucleoside recognition; Region: Gate; pfam07670 661367001171 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 661367001172 Nucleoside recognition; Region: Gate; pfam07670 661367001173 FeoC like transcriptional regulator; Region: FeoC; pfam09012 661367001174 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 661367001175 Iron-sulfur protein interface; other site 661367001176 proximal quinone binding site [chemical binding]; other site 661367001177 SdhD (CybS) interface [polypeptide binding]; other site 661367001178 proximal heme binding site [chemical binding]; other site 661367001179 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 661367001180 SdhC subunit interface [polypeptide binding]; other site 661367001181 proximal heme binding site [chemical binding]; other site 661367001182 cardiolipin binding site; other site 661367001183 Iron-sulfur protein interface; other site 661367001184 proximal quinone binding site [chemical binding]; other site 661367001185 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 661367001186 L-aspartate oxidase; Provisional; Region: PRK06175 661367001187 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367001188 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 661367001189 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 661367001190 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 661367001191 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 661367001192 TPP-binding site [chemical binding]; other site 661367001193 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 661367001194 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 661367001195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367001196 E3 interaction surface; other site 661367001197 lipoyl attachment site [posttranslational modification]; other site 661367001198 e3 binding domain; Region: E3_binding; pfam02817 661367001199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 661367001200 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 661367001201 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 661367001202 CoA-ligase; Region: Ligase_CoA; pfam00549 661367001203 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 661367001204 CoA binding domain; Region: CoA_binding; pfam02629 661367001205 CoA-ligase; Region: Ligase_CoA; pfam00549 661367001206 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 661367001207 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 661367001208 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 661367001209 Ribosome modulation factor; Region: RMF; cl01207 661367001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001211 D-galactonate transporter; Region: 2A0114; TIGR00893 661367001212 putative substrate translocation pore; other site 661367001213 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 661367001214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 661367001215 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 661367001216 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 661367001217 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 661367001218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001219 active site 661367001220 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 661367001221 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 661367001222 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 661367001223 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 661367001224 active site 661367001225 (T/H)XGH motif; other site 661367001226 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 661367001227 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 661367001228 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 661367001229 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 661367001230 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 661367001231 DXD motif; other site 661367001232 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367001233 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367001234 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 661367001235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 661367001236 putative acyl-acceptor binding pocket; other site 661367001237 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 661367001238 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 661367001239 DNA binding site [nucleotide binding] 661367001240 catalytic residue [active] 661367001241 H2TH interface [polypeptide binding]; other site 661367001242 putative catalytic residues [active] 661367001243 turnover-facilitating residue; other site 661367001244 intercalation triad [nucleotide binding]; other site 661367001245 8OG recognition residue [nucleotide binding]; other site 661367001246 putative reading head residues; other site 661367001247 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 661367001248 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 661367001249 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367001250 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367001251 Di-iron ligands [ion binding]; other site 661367001252 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367001253 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 661367001254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001255 NAD(P) binding site [chemical binding]; other site 661367001256 active site 661367001257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001258 NAD(P) binding site [chemical binding]; other site 661367001259 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 661367001260 active site 661367001261 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 661367001262 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 661367001263 Phasin protein; Region: Phasin_2; cl11491 661367001264 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 661367001265 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 661367001266 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 661367001267 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 661367001268 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001269 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001270 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001271 Pirin-related protein [General function prediction only]; Region: COG1741 661367001272 Pirin; Region: Pirin; pfam02678 661367001273 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 661367001274 malate dehydrogenase; Provisional; Region: PRK13529 661367001275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367001276 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 661367001277 NAD(P) binding site [chemical binding]; other site 661367001278 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 661367001279 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 661367001280 putative C-terminal domain interface [polypeptide binding]; other site 661367001281 putative GSH binding site [chemical binding]; other site 661367001282 putative dimer interface [polypeptide binding]; other site 661367001283 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 661367001284 putative N-terminal domain interface [polypeptide binding]; other site 661367001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367001286 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 661367001287 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 661367001288 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 661367001289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367001290 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367001291 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367001292 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367001293 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 661367001294 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 661367001295 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 661367001296 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 661367001297 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 661367001298 substrate binding site [chemical binding]; other site 661367001299 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 661367001300 nucleotide binding site/active site [active] 661367001301 HIT family signature motif; other site 661367001302 catalytic residue [active] 661367001303 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 661367001304 catalytic residues [active] 661367001305 dimer interface [polypeptide binding]; other site 661367001306 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367001307 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 661367001308 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 661367001309 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367001310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 661367001311 Walker A/P-loop; other site 661367001312 ATP binding site [chemical binding]; other site 661367001313 Q-loop/lid; other site 661367001314 ABC transporter signature motif; other site 661367001315 Walker B; other site 661367001316 D-loop; other site 661367001317 H-loop/switch region; other site 661367001318 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367001319 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367001320 YhhN-like protein; Region: YhhN; pfam07947 661367001321 U-box domain; Region: U-box; cl17544 661367001322 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 661367001323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 661367001324 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 661367001325 substrate binding site [chemical binding]; other site 661367001326 ATP binding site [chemical binding]; other site 661367001327 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 661367001328 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 661367001329 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 661367001330 putative dimer interface [polypeptide binding]; other site 661367001331 N-terminal domain interface [polypeptide binding]; other site 661367001332 putative substrate binding pocket (H-site) [chemical binding]; other site 661367001333 aconitate hydratase; Validated; Region: PRK07229 661367001334 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 661367001335 substrate binding site [chemical binding]; other site 661367001336 ligand binding site [chemical binding]; other site 661367001337 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 661367001338 substrate binding site [chemical binding]; other site 661367001339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001340 active site 661367001341 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 661367001342 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 661367001343 putative NAD(P) binding site [chemical binding]; other site 661367001344 homotetramer interface [polypeptide binding]; other site 661367001345 homodimer interface [polypeptide binding]; other site 661367001346 active site 661367001347 elongation factor P; Validated; Region: PRK00529 661367001348 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 661367001349 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 661367001350 RNA binding site [nucleotide binding]; other site 661367001351 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 661367001352 RNA binding site [nucleotide binding]; other site 661367001353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367001354 FeS/SAM binding site; other site 661367001355 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 661367001356 dimer interface [polypeptide binding]; other site 661367001357 catalytic triad [active] 661367001358 polyphosphate kinase; Provisional; Region: PRK05443 661367001359 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 661367001360 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 661367001361 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 661367001362 putative active site [active] 661367001363 catalytic site [active] 661367001364 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 661367001365 putative domain interface [polypeptide binding]; other site 661367001366 putative active site [active] 661367001367 catalytic site [active] 661367001368 Chromate transporter; Region: Chromate_transp; pfam02417 661367001369 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 661367001370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367001371 active site 661367001372 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 661367001373 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 661367001374 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 661367001375 Substrate binding site; other site 661367001376 metal-binding site 661367001377 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 661367001378 Phosphotransferase enzyme family; Region: APH; pfam01636 661367001379 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 661367001380 OstA-like protein; Region: OstA; cl00844 661367001381 Organic solvent tolerance protein; Region: OstA_C; pfam04453 661367001382 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 661367001383 SurA N-terminal domain; Region: SurA_N; pfam09312 661367001384 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 661367001385 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 661367001386 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 661367001387 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 661367001388 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 661367001389 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 661367001390 folate binding site [chemical binding]; other site 661367001391 NADP+ binding site [chemical binding]; other site 661367001392 elongation factor Tu; Reviewed; Region: PRK00049 661367001393 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 661367001394 G1 box; other site 661367001395 GEF interaction site [polypeptide binding]; other site 661367001396 GTP/Mg2+ binding site [chemical binding]; other site 661367001397 Switch I region; other site 661367001398 G2 box; other site 661367001399 G3 box; other site 661367001400 Switch II region; other site 661367001401 G4 box; other site 661367001402 G5 box; other site 661367001403 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 661367001404 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 661367001405 Antibiotic Binding Site [chemical binding]; other site 661367001406 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 661367001407 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 661367001408 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 661367001409 putative homodimer interface [polypeptide binding]; other site 661367001410 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 661367001411 heterodimer interface [polypeptide binding]; other site 661367001412 homodimer interface [polypeptide binding]; other site 661367001413 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 661367001414 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 661367001415 23S rRNA interface [nucleotide binding]; other site 661367001416 L7/L12 interface [polypeptide binding]; other site 661367001417 putative thiostrepton binding site; other site 661367001418 L25 interface [polypeptide binding]; other site 661367001419 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 661367001420 mRNA/rRNA interface [nucleotide binding]; other site 661367001421 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 661367001422 23S rRNA interface [nucleotide binding]; other site 661367001423 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 661367001424 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 661367001425 peripheral dimer interface [polypeptide binding]; other site 661367001426 core dimer interface [polypeptide binding]; other site 661367001427 L10 interface [polypeptide binding]; other site 661367001428 L11 interface [polypeptide binding]; other site 661367001429 putative EF-Tu interaction site [polypeptide binding]; other site 661367001430 putative EF-G interaction site [polypeptide binding]; other site 661367001431 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 661367001432 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 661367001433 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 661367001434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 661367001435 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 661367001436 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 661367001437 RPB3 interaction site [polypeptide binding]; other site 661367001438 RPB1 interaction site [polypeptide binding]; other site 661367001439 RPB11 interaction site [polypeptide binding]; other site 661367001440 RPB10 interaction site [polypeptide binding]; other site 661367001441 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 661367001442 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 661367001443 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 661367001444 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 661367001445 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 661367001446 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 661367001447 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 661367001448 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 661367001449 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 661367001450 DNA binding site [nucleotide binding] 661367001451 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 661367001452 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 661367001453 S17 interaction site [polypeptide binding]; other site 661367001454 S8 interaction site; other site 661367001455 16S rRNA interaction site [nucleotide binding]; other site 661367001456 streptomycin interaction site [chemical binding]; other site 661367001457 23S rRNA interaction site [nucleotide binding]; other site 661367001458 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 661367001459 30S ribosomal protein S7; Validated; Region: PRK05302 661367001460 elongation factor G; Reviewed; Region: PRK00007 661367001461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 661367001462 G1 box; other site 661367001463 putative GEF interaction site [polypeptide binding]; other site 661367001464 GTP/Mg2+ binding site [chemical binding]; other site 661367001465 Switch I region; other site 661367001466 G2 box; other site 661367001467 G3 box; other site 661367001468 Switch II region; other site 661367001469 G4 box; other site 661367001470 G5 box; other site 661367001471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 661367001472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 661367001473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 661367001474 elongation factor Tu; Reviewed; Region: PRK00049 661367001475 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 661367001476 G1 box; other site 661367001477 GEF interaction site [polypeptide binding]; other site 661367001478 GTP/Mg2+ binding site [chemical binding]; other site 661367001479 Switch I region; other site 661367001480 G2 box; other site 661367001481 G3 box; other site 661367001482 Switch II region; other site 661367001483 G4 box; other site 661367001484 G5 box; other site 661367001485 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 661367001486 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 661367001487 Antibiotic Binding Site [chemical binding]; other site 661367001488 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 661367001489 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 661367001490 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 661367001491 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 661367001492 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 661367001493 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 661367001494 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 661367001495 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 661367001496 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 661367001497 putative translocon binding site; other site 661367001498 protein-rRNA interface [nucleotide binding]; other site 661367001499 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 661367001500 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 661367001501 G-X-X-G motif; other site 661367001502 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 661367001503 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 661367001504 23S rRNA interface [nucleotide binding]; other site 661367001505 5S rRNA interface [nucleotide binding]; other site 661367001506 putative antibiotic binding site [chemical binding]; other site 661367001507 L25 interface [polypeptide binding]; other site 661367001508 L27 interface [polypeptide binding]; other site 661367001509 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 661367001510 23S rRNA interface [nucleotide binding]; other site 661367001511 putative translocon interaction site; other site 661367001512 signal recognition particle (SRP54) interaction site; other site 661367001513 L23 interface [polypeptide binding]; other site 661367001514 trigger factor interaction site; other site 661367001515 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 661367001516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 661367001517 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 661367001518 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 661367001519 RNA binding site [nucleotide binding]; other site 661367001520 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 661367001521 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 661367001522 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 661367001523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK06911 661367001524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 661367001525 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 661367001526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 661367001527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 661367001528 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 661367001529 23S rRNA interface [nucleotide binding]; other site 661367001530 L21e interface [polypeptide binding]; other site 661367001531 5S rRNA interface [nucleotide binding]; other site 661367001532 L27 interface [polypeptide binding]; other site 661367001533 L5 interface [polypeptide binding]; other site 661367001534 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 661367001535 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 661367001536 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 661367001537 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 661367001538 23S rRNA binding site [nucleotide binding]; other site 661367001539 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 661367001540 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 661367001541 SecY translocase; Region: SecY; pfam00344 661367001542 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 661367001543 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 661367001544 30S ribosomal protein S13; Region: bact_S13; TIGR03631 661367001545 30S ribosomal protein S11; Validated; Region: PRK05309 661367001546 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 661367001547 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 661367001548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367001549 RNA binding surface [nucleotide binding]; other site 661367001550 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 661367001551 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 661367001552 alphaNTD homodimer interface [polypeptide binding]; other site 661367001553 alphaNTD - beta interaction site [polypeptide binding]; other site 661367001554 alphaNTD - beta' interaction site [polypeptide binding]; other site 661367001555 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 661367001556 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 661367001557 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 661367001558 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 661367001559 dimer interface [polypeptide binding]; other site 661367001560 ssDNA binding site [nucleotide binding]; other site 661367001561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 661367001562 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 661367001563 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 661367001564 DNA binding residues [nucleotide binding] 661367001565 dimer interface [polypeptide binding]; other site 661367001566 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 661367001567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 661367001568 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 661367001569 chaperone protein HchA; Provisional; Region: PRK04155 661367001570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367001572 putative substrate translocation pore; other site 661367001573 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 661367001574 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 661367001575 putative NAD(P) binding site [chemical binding]; other site 661367001576 active site 661367001577 acyl carrier protein; Provisional; Region: acpP; PRK00982 661367001578 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 661367001579 active site 2 [active] 661367001580 active site 1 [active] 661367001581 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 661367001582 active site 2 [active] 661367001583 dimer interface [polypeptide binding]; other site 661367001584 active site 1 [active] 661367001585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367001586 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367001587 dimer interface [polypeptide binding]; other site 661367001588 active site 661367001589 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 661367001590 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 661367001591 active site 661367001592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 661367001593 putative acyl-acceptor binding pocket; other site 661367001594 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 661367001595 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 661367001596 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 661367001597 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 661367001598 putative hydrolase; Provisional; Region: PRK11460 661367001599 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 661367001600 putative coenzyme Q binding site [chemical binding]; other site 661367001601 hypothetical protein; Validated; Region: PRK01777 661367001602 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 661367001603 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 661367001604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 661367001605 metal binding site 2 [ion binding]; metal-binding site 661367001606 putative DNA binding helix; other site 661367001607 metal binding site 1 [ion binding]; metal-binding site 661367001608 dimer interface [polypeptide binding]; other site 661367001609 structural Zn2+ binding site [ion binding]; other site 661367001610 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 661367001611 cyclase homology domain; Region: CHD; cd07302 661367001612 nucleotidyl binding site; other site 661367001613 metal binding site [ion binding]; metal-binding site 661367001614 dimer interface [polypeptide binding]; other site 661367001615 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 661367001616 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 661367001617 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367001618 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367001619 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367001620 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001621 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 661367001622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001623 putative substrate translocation pore; other site 661367001624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001625 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 661367001626 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367001627 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367001628 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367001629 Entericidin EcnA/B family; Region: Entericidin; cl02322 661367001630 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 661367001631 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 661367001632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 661367001633 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367001634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001635 NAD(P) binding site [chemical binding]; other site 661367001636 active site 661367001637 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 661367001638 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367001639 dimer interface [polypeptide binding]; other site 661367001640 active site 661367001641 CoA binding pocket [chemical binding]; other site 661367001642 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001643 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367001644 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367001645 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367001646 multidrug efflux protein; Reviewed; Region: PRK09579 661367001647 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 661367001648 active site 2 [active] 661367001649 active site 1 [active] 661367001650 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367001651 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 661367001652 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 661367001653 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 661367001654 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 661367001655 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 661367001656 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 661367001657 heat shock protein HtpX; Provisional; Region: PRK02870 661367001658 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 661367001659 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 661367001660 putative metal binding site [ion binding]; other site 661367001661 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367001662 HSP70 interaction site [polypeptide binding]; other site 661367001663 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 661367001664 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 661367001665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367001666 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 661367001667 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 661367001668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001669 S-adenosylmethionine binding site [chemical binding]; other site 661367001670 peptide chain release factor 1; Validated; Region: prfA; PRK00591 661367001671 This domain is found in peptide chain release factors; Region: PCRF; smart00937 661367001672 RF-1 domain; Region: RF-1; pfam00472 661367001673 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 661367001674 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 661367001675 tRNA; other site 661367001676 putative tRNA binding site [nucleotide binding]; other site 661367001677 putative NADP binding site [chemical binding]; other site 661367001678 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 661367001679 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367001680 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 661367001681 active site 661367001682 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367001683 protein binding site [polypeptide binding]; other site 661367001684 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 661367001685 putative substrate binding region [chemical binding]; other site 661367001686 DNA utilization protein GntX; Provisional; Region: PRK11595 661367001687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001688 active site 661367001689 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 661367001690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001691 S-adenosylmethionine binding site [chemical binding]; other site 661367001692 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 661367001693 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367001694 substrate binding pocket [chemical binding]; other site 661367001695 chain length determination region; other site 661367001696 substrate-Mg2+ binding site; other site 661367001697 catalytic residues [active] 661367001698 aspartate-rich region 1; other site 661367001699 active site lid residues [active] 661367001700 aspartate-rich region 2; other site 661367001701 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 661367001702 DNA repair protein RadA; Provisional; Region: PRK11823 661367001703 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367001704 Walker A motif; other site 661367001705 ATP binding site [chemical binding]; other site 661367001706 Walker B motif; other site 661367001707 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 661367001708 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 661367001709 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367001710 Walker A motif; other site 661367001711 ATP binding site [chemical binding]; other site 661367001712 Walker B motif; other site 661367001713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367001714 glutamate racemase; Provisional; Region: PRK00865 661367001715 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367001716 GIY-YIG motif/motif A; other site 661367001717 putative active site [active] 661367001718 putative metal binding site [ion binding]; other site 661367001719 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 661367001720 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 661367001721 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 661367001722 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 661367001723 SecA binding site; other site 661367001724 Preprotein binding site; other site 661367001725 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 661367001726 GSH binding site [chemical binding]; other site 661367001727 catalytic residues [active] 661367001728 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367001729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 661367001730 Smr domain; Region: Smr; pfam01713 661367001731 HemK family putative methylases; Region: hemK_fam; TIGR00536 661367001732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001733 S-adenosylmethionine binding site [chemical binding]; other site 661367001734 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 661367001735 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 661367001736 Tetramer interface [polypeptide binding]; other site 661367001737 active site 661367001738 FMN-binding site [chemical binding]; other site 661367001739 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 661367001740 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 661367001741 Smr domain; Region: Smr; pfam01713 661367001742 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367001743 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367001744 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 661367001745 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367001746 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 661367001747 putative NAD(P) binding site [chemical binding]; other site 661367001748 putative substrate binding site [chemical binding]; other site 661367001749 catalytic Zn binding site [ion binding]; other site 661367001750 structural Zn binding site [ion binding]; other site 661367001751 dimer interface [polypeptide binding]; other site 661367001752 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 661367001753 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 661367001754 homodimer interface [polypeptide binding]; other site 661367001755 oligonucleotide binding site [chemical binding]; other site 661367001756 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 661367001757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367001758 RNA binding surface [nucleotide binding]; other site 661367001759 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 661367001760 active site 661367001761 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 661367001762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367001763 motif II; other site 661367001764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367001765 EamA-like transporter family; Region: EamA; cl17759 661367001766 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 661367001767 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367001768 FtsX-like permease family; Region: FtsX; pfam02687 661367001769 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 661367001770 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 661367001771 Walker A/P-loop; other site 661367001772 ATP binding site [chemical binding]; other site 661367001773 Q-loop/lid; other site 661367001774 ABC transporter signature motif; other site 661367001775 Walker B; other site 661367001776 D-loop; other site 661367001777 H-loop/switch region; other site 661367001778 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 661367001779 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 661367001780 putative dimer interface [polypeptide binding]; other site 661367001781 putative anticodon binding site; other site 661367001782 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 661367001783 homodimer interface [polypeptide binding]; other site 661367001784 motif 1; other site 661367001785 motif 2; other site 661367001786 active site 661367001787 motif 3; other site 661367001788 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 661367001789 maleylacetoacetate isomerase; Region: maiA; TIGR01262 661367001790 C-terminal domain interface [polypeptide binding]; other site 661367001791 GSH binding site (G-site) [chemical binding]; other site 661367001792 putative dimer interface [polypeptide binding]; other site 661367001793 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 661367001794 dimer interface [polypeptide binding]; other site 661367001795 N-terminal domain interface [polypeptide binding]; other site 661367001796 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 661367001797 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 661367001798 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 661367001799 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 661367001800 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 661367001801 dimer interface [polypeptide binding]; other site 661367001802 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 661367001803 active site 661367001804 Fe binding site [ion binding]; other site 661367001805 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 661367001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367001807 S-adenosylmethionine binding site [chemical binding]; other site 661367001808 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 661367001809 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 661367001810 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 661367001811 NAD binding site [chemical binding]; other site 661367001812 Phe binding site; other site 661367001813 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 661367001814 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 661367001815 putative active site [active] 661367001816 catalytic site [active] 661367001817 putative metal binding site [ion binding]; other site 661367001818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 661367001819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 661367001820 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 661367001821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 661367001822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367001823 catalytic residue [active] 661367001824 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 661367001825 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 661367001826 substrate binding site [chemical binding]; other site 661367001827 hexamer interface [polypeptide binding]; other site 661367001828 metal binding site [ion binding]; metal-binding site 661367001829 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 661367001830 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 661367001831 metal binding triad; other site 661367001832 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 661367001833 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 661367001834 metal binding triad; other site 661367001835 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 661367001836 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 661367001837 TRAM domain; Region: TRAM; cl01282 661367001838 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 661367001839 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 661367001840 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367001841 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 661367001842 DsbD alpha interface [polypeptide binding]; other site 661367001843 catalytic residues [active] 661367001844 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 661367001845 oligomerisation interface [polypeptide binding]; other site 661367001846 mobile loop; other site 661367001847 roof hairpin; other site 661367001848 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 661367001849 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 661367001850 ring oligomerisation interface [polypeptide binding]; other site 661367001851 ATP/Mg binding site [chemical binding]; other site 661367001852 stacking interactions; other site 661367001853 hinge regions; other site 661367001854 Ferritin-like domain; Region: Ferritin; pfam00210 661367001855 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 661367001856 dimerization interface [polypeptide binding]; other site 661367001857 DPS ferroxidase diiron center [ion binding]; other site 661367001858 ion pore; other site 661367001859 acetoacetate decarboxylase; Provisional; Region: PRK02265 661367001860 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 661367001861 classical (c) SDRs; Region: SDR_c; cd05233 661367001862 NAD(P) binding site [chemical binding]; other site 661367001863 active site 661367001864 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 661367001865 dihydrodipicolinate synthase; Region: dapA; TIGR00674 661367001866 dimer interface [polypeptide binding]; other site 661367001867 active site 661367001868 catalytic residue [active] 661367001869 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 661367001870 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 661367001871 Zeta toxin; Region: Zeta_toxin; pfam06414 661367001872 16S rRNA methyltransferase B; Provisional; Region: PRK10901 661367001873 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 661367001874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001875 S-adenosylmethionine binding site [chemical binding]; other site 661367001876 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 661367001877 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 661367001878 putative active site [active] 661367001879 substrate binding site [chemical binding]; other site 661367001880 putative cosubstrate binding site; other site 661367001881 catalytic site [active] 661367001882 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 661367001883 substrate binding site [chemical binding]; other site 661367001884 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 661367001885 active site 661367001886 catalytic residues [active] 661367001887 metal binding site [ion binding]; metal-binding site 661367001888 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 661367001889 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367001890 hypothetical protein; Provisional; Region: PRK10736 661367001891 DNA protecting protein DprA; Region: dprA; TIGR00732 661367001892 Protein of unknown function (DUF494); Region: DUF494; pfam04361 661367001893 DNA topoisomerase I; Validated; Region: PRK06599 661367001894 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 661367001895 active site 661367001896 interdomain interaction site; other site 661367001897 putative metal-binding site [ion binding]; other site 661367001898 nucleotide binding site [chemical binding]; other site 661367001899 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 661367001900 domain I; other site 661367001901 DNA binding groove [nucleotide binding] 661367001902 phosphate binding site [ion binding]; other site 661367001903 domain II; other site 661367001904 domain III; other site 661367001905 nucleotide binding site [chemical binding]; other site 661367001906 catalytic site [active] 661367001907 domain IV; other site 661367001908 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001909 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 661367001910 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001911 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001912 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 661367001913 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 661367001914 tetramer interface [polypeptide binding]; other site 661367001915 TPP-binding site [chemical binding]; other site 661367001916 heterodimer interface [polypeptide binding]; other site 661367001917 phosphorylation loop region [posttranslational modification] 661367001918 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 661367001919 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 661367001920 alpha subunit interface [polypeptide binding]; other site 661367001921 TPP binding site [chemical binding]; other site 661367001922 heterodimer interface [polypeptide binding]; other site 661367001923 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367001924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367001925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367001926 active site 661367001927 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367001928 Part of AAA domain; Region: AAA_19; pfam13245 661367001929 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 661367001930 Uncharacterized conserved protein [Function unknown]; Region: COG3410 661367001931 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 661367001932 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 661367001933 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 661367001934 active site 661367001935 Zn binding site [ion binding]; other site 661367001936 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 661367001937 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367001938 Divergent AAA domain; Region: AAA_4; pfam04326 661367001939 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 661367001940 integrase; Provisional; Region: PRK09692 661367001941 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 661367001942 active site 661367001943 Int/Topo IB signature motif; other site 661367001944 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 661367001945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367001946 non-specific DNA binding site [nucleotide binding]; other site 661367001947 salt bridge; other site 661367001948 sequence-specific DNA binding site [nucleotide binding]; other site 661367001949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367001950 PAS fold; Region: PAS_4; pfam08448 661367001951 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 661367001952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367001953 Zn2+ binding site [ion binding]; other site 661367001954 Mg2+ binding site [ion binding]; other site 661367001955 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 661367001956 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 661367001957 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367001958 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 661367001959 putative NAD(P) binding site [chemical binding]; other site 661367001960 FOG: CBS domain [General function prediction only]; Region: COG0517 661367001961 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619 661367001962 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 661367001963 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 661367001964 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 661367001965 Iron-sulfur protein interface; other site 661367001966 proximal quinone binding site [chemical binding]; other site 661367001967 SdhD (CybS) interface [polypeptide binding]; other site 661367001968 proximal heme binding site [chemical binding]; other site 661367001969 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 661367001970 SdhC subunit interface [polypeptide binding]; other site 661367001971 proximal heme binding site [chemical binding]; other site 661367001972 cardiolipin binding site; other site 661367001973 Iron-sulfur protein interface; other site 661367001974 proximal quinone binding site [chemical binding]; other site 661367001975 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 661367001976 L-aspartate oxidase; Provisional; Region: PRK06175 661367001977 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367001978 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367001979 endonuclease III; Region: ENDO3c; smart00478 661367001980 minor groove reading motif; other site 661367001981 helix-hairpin-helix signature motif; other site 661367001982 substrate binding pocket [chemical binding]; other site 661367001983 active site 661367001984 Uncharacterized conserved protein [Function unknown]; Region: COG3189 661367001985 aconitate hydratase; Validated; Region: PRK09277 661367001986 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367001987 substrate binding site [chemical binding]; other site 661367001988 ligand binding site [chemical binding]; other site 661367001989 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367001990 substrate binding site [chemical binding]; other site 661367001991 Rubredoxin [Energy production and conversion]; Region: COG1773 661367001992 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 661367001993 iron binding site [ion binding]; other site 661367001994 OsmC-like protein; Region: OsmC; cl00767 661367001995 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 661367001996 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 661367001997 probable galactinol--sucrose galactosyltransferase 2; Region: PLN02219 661367001998 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 661367001999 Protein of unknown function (DUF812); Region: DUF812; pfam05667 661367002000 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 661367002001 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 661367002002 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 661367002003 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 661367002004 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 661367002005 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 661367002006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367002007 putative DNA binding site [nucleotide binding]; other site 661367002008 putative Zn2+ binding site [ion binding]; other site 661367002009 AsnC family; Region: AsnC_trans_reg; pfam01037 661367002010 asparagine synthetase AsnA; Provisional; Region: PRK05425 661367002011 motif 1; other site 661367002012 dimer interface [polypeptide binding]; other site 661367002013 active site 661367002014 motif 2; other site 661367002015 motif 3; other site 661367002016 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367002017 HSP70 interaction site [polypeptide binding]; other site 661367002018 Cupin domain; Region: Cupin_2; cl17218 661367002019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 661367002020 PAS fold; Region: PAS_4; pfam08448 661367002021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367002023 dimer interface [polypeptide binding]; other site 661367002024 phosphorylation site [posttranslational modification] 661367002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002026 ATP binding site [chemical binding]; other site 661367002027 Mg2+ binding site [ion binding]; other site 661367002028 G-X-G motif; other site 661367002029 Response regulator receiver domain; Region: Response_reg; pfam00072 661367002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367002031 active site 661367002032 phosphorylation site [posttranslational modification] 661367002033 intermolecular recognition site; other site 661367002034 dimerization interface [polypeptide binding]; other site 661367002035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367002036 dimer interface [polypeptide binding]; other site 661367002037 phosphorylation site [posttranslational modification] 661367002038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002039 ATP binding site [chemical binding]; other site 661367002040 Mg2+ binding site [ion binding]; other site 661367002041 G-X-G motif; other site 661367002042 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367002043 putative active site [active] 661367002044 GIY-YIG motif/motif A; other site 661367002045 putative metal binding site [ion binding]; other site 661367002046 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 661367002047 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 661367002048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367002049 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367002050 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367002051 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367002052 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 661367002053 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 661367002054 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 661367002055 P-loop motif; other site 661367002056 ATP binding site [chemical binding]; other site 661367002057 Chloramphenicol (Cm) binding site [chemical binding]; other site 661367002058 catalytic residue [active] 661367002059 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 661367002060 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367002061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367002062 motif II; other site 661367002063 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 661367002064 metal binding site 2 [ion binding]; metal-binding site 661367002065 putative DNA binding helix; other site 661367002066 metal binding site 1 [ion binding]; metal-binding site 661367002067 dimer interface [polypeptide binding]; other site 661367002068 structural Zn2+ binding site [ion binding]; other site 661367002069 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367002070 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 661367002071 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 661367002072 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 661367002073 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 661367002074 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 661367002075 hypothetical protein; Reviewed; Region: PRK09588 661367002076 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 661367002077 EamA-like transporter family; Region: EamA; pfam00892 661367002078 EamA-like transporter family; Region: EamA; pfam00892 661367002079 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 661367002080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367002081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002082 S-adenosylmethionine binding site [chemical binding]; other site 661367002083 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002084 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002085 active site 661367002086 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002087 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002088 active site 661367002089 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367002090 KR domain; Region: KR; pfam08659 661367002091 putative NADP binding site [chemical binding]; other site 661367002092 active site 661367002093 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 661367002094 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002095 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002096 active site 661367002097 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 661367002098 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367002099 KR domain; Region: KR; pfam08659 661367002100 putative NADP binding site [chemical binding]; other site 661367002101 active site 661367002102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 661367002103 Condensation domain; Region: Condensation; pfam00668 661367002104 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 661367002105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367002106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367002107 motif II; other site 661367002108 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 661367002109 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 661367002110 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 661367002111 putative ligand binding site [chemical binding]; other site 661367002112 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 661367002113 putative NAD binding site [chemical binding]; other site 661367002114 putative catalytic site [active] 661367002115 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 661367002116 L-serine binding site [chemical binding]; other site 661367002117 ACT domain interface; other site 661367002118 phosphoserine phosphatase SerB; Region: serB; TIGR00338 661367002119 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 661367002120 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367002121 Sulfate transporter family; Region: Sulfate_transp; pfam00916 661367002122 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367002123 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367002124 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367002125 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367002126 ligand binding site [chemical binding]; other site 661367002127 flexible hinge region; other site 661367002128 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367002129 Erythromycin esterase; Region: Erythro_esteras; pfam05139 661367002130 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 661367002131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367002132 Walker A motif; other site 661367002133 ATP binding site [chemical binding]; other site 661367002134 Walker B motif; other site 661367002135 arginine finger; other site 661367002136 Peptidase family M41; Region: Peptidase_M41; pfam01434 661367002137 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367002138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 661367002139 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 661367002140 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 661367002141 Sulphur transport; Region: Sulf_transp; pfam04143 661367002142 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 661367002143 hypothetical protein; Provisional; Region: PRK07236 661367002144 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 661367002145 Isochorismatase family; Region: Isochorismatase; pfam00857 661367002146 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 661367002147 catalytic triad [active] 661367002148 conserved cis-peptide bond; other site 661367002149 Predicted membrane protein [Function unknown]; Region: COG1289 661367002150 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367002151 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 661367002152 putative FMN binding site [chemical binding]; other site 661367002153 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 661367002154 dimer interface [polypeptide binding]; other site 661367002155 catalytic triad [active] 661367002156 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 661367002157 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 661367002158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367002159 motif II; other site 661367002160 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 661367002161 active site 661367002162 catalytic residues [active] 661367002163 metal binding site [ion binding]; metal-binding site 661367002164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367002165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367002166 ligand binding site [chemical binding]; other site 661367002167 flexible hinge region; other site 661367002168 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367002169 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 661367002170 active site 661367002171 nucleophile elbow; other site 661367002172 MASE1; Region: MASE1; pfam05231 661367002173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367002174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367002175 dimer interface [polypeptide binding]; other site 661367002176 phosphorylation site [posttranslational modification] 661367002177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002178 ATP binding site [chemical binding]; other site 661367002179 Mg2+ binding site [ion binding]; other site 661367002180 G-X-G motif; other site 661367002181 Response regulator receiver domain; Region: Response_reg; pfam00072 661367002182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367002183 active site 661367002184 phosphorylation site [posttranslational modification] 661367002185 intermolecular recognition site; other site 661367002186 dimerization interface [polypeptide binding]; other site 661367002187 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367002188 cyclase homology domain; Region: CHD; cd07302 661367002189 nucleotidyl binding site; other site 661367002190 metal binding site [ion binding]; metal-binding site 661367002191 dimer interface [polypeptide binding]; other site 661367002192 hypothetical protein; Provisional; Region: PRK05409 661367002193 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 661367002194 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 661367002195 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 661367002196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367002197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 661367002198 active site 661367002199 metal binding site [ion binding]; metal-binding site 661367002200 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 661367002201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367002202 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 661367002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002204 Mg2+ binding site [ion binding]; other site 661367002205 G-X-G motif; other site 661367002206 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 661367002207 anchoring element; other site 661367002208 dimer interface [polypeptide binding]; other site 661367002209 ATP binding site [chemical binding]; other site 661367002210 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 661367002211 active site 661367002212 metal binding site [ion binding]; metal-binding site 661367002213 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 661367002214 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 661367002215 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 661367002216 Walker A/P-loop; other site 661367002217 ATP binding site [chemical binding]; other site 661367002218 Q-loop/lid; other site 661367002219 ABC transporter signature motif; other site 661367002220 Walker B; other site 661367002221 D-loop; other site 661367002222 H-loop/switch region; other site 661367002223 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 661367002224 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 661367002225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 661367002226 Walker A/P-loop; other site 661367002227 ATP binding site [chemical binding]; other site 661367002228 Q-loop/lid; other site 661367002229 ABC transporter signature motif; other site 661367002230 Walker B; other site 661367002231 D-loop; other site 661367002232 H-loop/switch region; other site 661367002233 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 661367002234 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 661367002235 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 661367002236 DJ-1 family protein; Region: not_thiJ; TIGR01383 661367002237 conserved cys residue [active] 661367002238 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 661367002239 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367002240 NodB motif; other site 661367002241 putative active site [active] 661367002242 putative catalytic site [active] 661367002243 putative Zn binding site [ion binding]; other site 661367002244 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 661367002245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 661367002246 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 661367002247 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 661367002248 Ligand binding site; other site 661367002249 Putative Catalytic site; other site 661367002250 DXD motif; other site 661367002251 GtrA-like protein; Region: GtrA; pfam04138 661367002252 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 661367002253 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 661367002254 Uncharacterized conserved protein [Function unknown]; Region: COG0393 661367002255 Uncharacterized conserved protein [Function unknown]; Region: COG0393 661367002256 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 661367002257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367002258 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 661367002259 Domain of unknown function DUF20; Region: UPF0118; pfam01594 661367002260 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 661367002261 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002262 ATP binding site [chemical binding]; other site 661367002263 putative Mg++ binding site [ion binding]; other site 661367002264 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002265 nucleotide binding region [chemical binding]; other site 661367002266 ATP-binding site [chemical binding]; other site 661367002267 DEAD/H associated; Region: DEAD_assoc; pfam08494 661367002268 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 661367002269 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 661367002270 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 661367002271 Isochorismatase family; Region: Isochorismatase; pfam00857 661367002272 catalytic triad [active] 661367002273 metal binding site [ion binding]; metal-binding site 661367002274 conserved cis-peptide bond; other site 661367002275 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 661367002276 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 661367002277 active site 661367002278 Uncharacterized conserved protein [Function unknown]; Region: COG1434 661367002279 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 661367002280 putative active site [active] 661367002281 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 661367002282 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 661367002283 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 661367002284 putative NAD(P) binding site [chemical binding]; other site 661367002285 Nitronate monooxygenase; Region: NMO; pfam03060 661367002286 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 661367002287 FMN binding site [chemical binding]; other site 661367002288 substrate binding site [chemical binding]; other site 661367002289 putative catalytic residue [active] 661367002290 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367002291 GIY-YIG motif/motif A; other site 661367002292 active site 661367002293 catalytic site [active] 661367002294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 661367002295 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 661367002296 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 661367002297 active site clefts [active] 661367002298 zinc binding site [ion binding]; other site 661367002299 dimer interface [polypeptide binding]; other site 661367002300 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 661367002301 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 661367002302 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 661367002303 prolyl-tRNA synthetase; Provisional; Region: PRK09194 661367002304 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 661367002305 dimer interface [polypeptide binding]; other site 661367002306 motif 1; other site 661367002307 active site 661367002308 motif 2; other site 661367002309 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 661367002310 putative deacylase active site [active] 661367002311 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 661367002312 active site 661367002313 motif 3; other site 661367002314 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 661367002315 anticodon binding site; other site 661367002316 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367002317 Sulfate transporter family; Region: Sulfate_transp; pfam00916 661367002318 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367002319 active site clefts [active] 661367002320 zinc binding site [ion binding]; other site 661367002321 dimer interface [polypeptide binding]; other site 661367002322 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 661367002323 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 661367002324 Ligand Binding Site [chemical binding]; other site 661367002325 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 661367002326 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 661367002327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002328 S-adenosylmethionine binding site [chemical binding]; other site 661367002329 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 661367002330 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 661367002331 substrate-cofactor binding pocket; other site 661367002332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367002333 catalytic residue [active] 661367002334 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 661367002335 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 661367002336 NAD(P) binding site [chemical binding]; other site 661367002337 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 661367002338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002340 ABC transporter; Region: ABC_tran_2; pfam12848 661367002341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002342 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367002343 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367002344 formimidoylglutamase; Provisional; Region: PRK13775 661367002345 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 661367002346 putative active site [active] 661367002347 putative metal binding site [ion binding]; other site 661367002348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002349 short chain dehydrogenase; Provisional; Region: PRK06924 661367002350 NAD(P) binding site [chemical binding]; other site 661367002351 active site 661367002352 imidazolonepropionase; Validated; Region: PRK09356 661367002353 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 661367002354 active site 661367002355 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 661367002356 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 661367002357 Predicted membrane protein [Function unknown]; Region: COG1297 661367002358 putative oligopeptide transporter, OPT family; Region: TIGR00733 661367002359 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 661367002360 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 661367002361 HIGH motif; other site 661367002362 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367002363 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 661367002364 active site 661367002365 KMSKS motif; other site 661367002366 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 661367002367 tRNA binding surface [nucleotide binding]; other site 661367002368 anticodon binding site; other site 661367002369 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 661367002370 multidrug efflux protein; Reviewed; Region: PRK09579 661367002371 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367002372 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367002373 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367002374 BON domain; Region: BON; pfam04972 661367002375 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 661367002376 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 661367002377 dimer interface [polypeptide binding]; other site 661367002378 active site 661367002379 glycine-pyridoxal phosphate binding site [chemical binding]; other site 661367002380 folate binding site [chemical binding]; other site 661367002381 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 661367002382 ATP cone domain; Region: ATP-cone; pfam03477 661367002383 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 661367002384 putative RNA binding site [nucleotide binding]; other site 661367002385 thiamine monophosphate kinase; Provisional; Region: PRK05731 661367002386 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 661367002387 ATP binding site [chemical binding]; other site 661367002388 dimerization interface [polypeptide binding]; other site 661367002389 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 661367002390 tetramer interfaces [polypeptide binding]; other site 661367002391 binuclear metal-binding site [ion binding]; other site 661367002392 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 661367002393 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 661367002394 NAD synthetase; Provisional; Region: PRK13981 661367002395 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 661367002396 multimer interface [polypeptide binding]; other site 661367002397 active site 661367002398 catalytic triad [active] 661367002399 protein interface 1 [polypeptide binding]; other site 661367002400 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 661367002401 homodimer interface [polypeptide binding]; other site 661367002402 NAD binding pocket [chemical binding]; other site 661367002403 ATP binding pocket [chemical binding]; other site 661367002404 Mg binding site [ion binding]; other site 661367002405 active-site loop [active] 661367002406 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 661367002407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002408 ATP binding site [chemical binding]; other site 661367002409 putative Mg++ binding site [ion binding]; other site 661367002410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002411 nucleotide binding region [chemical binding]; other site 661367002412 ATP-binding site [chemical binding]; other site 661367002413 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 661367002414 replicative DNA helicase; Region: DnaB; TIGR00665 661367002415 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 661367002416 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 661367002417 Walker A motif; other site 661367002418 ATP binding site [chemical binding]; other site 661367002419 Walker B motif; other site 661367002420 DNA binding loops [nucleotide binding] 661367002421 alanine racemase; Reviewed; Region: alr; PRK00053 661367002422 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 661367002423 active site 661367002424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367002425 substrate binding site [chemical binding]; other site 661367002426 catalytic residues [active] 661367002427 dimer interface [polypeptide binding]; other site 661367002428 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 661367002429 DNA polymerase II large subunit DP2; Region: PolC_DP2; pfam03833 661367002430 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 661367002431 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 661367002432 metal binding site [ion binding]; metal-binding site 661367002433 dimer interface [polypeptide binding]; other site 661367002434 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 661367002435 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 661367002436 trimer interface [polypeptide binding]; other site 661367002437 active site 661367002438 substrate binding site [chemical binding]; other site 661367002439 CoA binding site [chemical binding]; other site 661367002440 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 661367002441 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 661367002442 homodimer interface [polypeptide binding]; other site 661367002443 substrate-cofactor binding pocket; other site 661367002444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367002445 catalytic residue [active] 661367002446 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 661367002447 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367002448 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 661367002449 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367002450 minor groove reading motif; other site 661367002451 helix-hairpin-helix signature motif; other site 661367002452 substrate binding pocket [chemical binding]; other site 661367002453 active site 661367002454 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 661367002455 DNA binding and oxoG recognition site [nucleotide binding] 661367002456 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 661367002457 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 661367002458 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367002459 protein binding site [polypeptide binding]; other site 661367002460 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 661367002461 Isochorismatase family; Region: Isochorismatase; pfam00857 661367002462 dimer interface [polypeptide binding]; other site 661367002463 catalytic triad [active] 661367002464 conserved cis-peptide bond; other site 661367002465 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 661367002466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002467 NAD(P) binding site [chemical binding]; other site 661367002468 active site 661367002469 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 661367002470 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 661367002471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367002472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 661367002473 nucleotide binding site [chemical binding]; other site 661367002474 Type III pantothenate kinase; Region: Pan_kinase; cl17198 661367002475 cell division protein MraZ; Reviewed; Region: PRK00326 661367002476 MraZ protein; Region: MraZ; pfam02381 661367002477 MraZ protein; Region: MraZ; pfam02381 661367002478 MraW methylase family; Region: Methyltransf_5; pfam01795 661367002479 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 661367002480 Cell division protein FtsL; Region: FtsL; cl11433 661367002481 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 661367002482 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 661367002483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 661367002484 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 661367002485 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367002486 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367002487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367002488 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 661367002489 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 661367002490 ligand binding site [chemical binding]; other site 661367002491 NAD binding site [chemical binding]; other site 661367002492 catalytic site [active] 661367002493 homodimer interface [polypeptide binding]; other site 661367002494 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 661367002495 Peptidase family M50; Region: Peptidase_M50; pfam02163 661367002496 active site 661367002497 putative substrate binding region [chemical binding]; other site 661367002498 Amino acid permease; Region: AA_permease_2; pfam13520 661367002499 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 661367002500 active site 661367002501 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 661367002502 Ligand binding site [chemical binding]; other site 661367002503 Electron transfer flavoprotein domain; Region: ETF; pfam01012 661367002504 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 661367002505 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 661367002506 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 661367002507 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 661367002508 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 661367002509 hexamer interface [polypeptide binding]; other site 661367002510 ligand binding site [chemical binding]; other site 661367002511 putative active site [active] 661367002512 NAD(P) binding site [chemical binding]; other site 661367002513 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 661367002514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002515 S-adenosylmethionine binding site [chemical binding]; other site 661367002516 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 661367002517 Transglycosylase; Region: Transgly; pfam00912 661367002518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 661367002519 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367002520 Competence protein A; Region: Competence_A; pfam11104 661367002521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 661367002522 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 661367002523 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 661367002524 Pilus assembly protein, PilO; Region: PilO; pfam04350 661367002525 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 661367002526 Pilus assembly protein, PilP; Region: PilP; pfam04351 661367002527 AMIN domain; Region: AMIN; pfam11741 661367002528 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 661367002529 Secretin and TonB N terminus short domain; Region: STN; smart00965 661367002530 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367002531 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 661367002532 shikimate kinase; Reviewed; Region: aroK; PRK00131 661367002533 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 661367002534 ADP binding site [chemical binding]; other site 661367002535 magnesium binding site [ion binding]; other site 661367002536 putative shikimate binding site; other site 661367002537 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 661367002538 active site 661367002539 dimer interface [polypeptide binding]; other site 661367002540 metal binding site [ion binding]; metal-binding site 661367002541 AAA domain; Region: AAA_22; pfam13401 661367002542 cell division protein DamX; Validated; Region: PRK10905 661367002543 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 661367002544 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 661367002545 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 661367002546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 661367002547 active site 661367002548 dimer interface [polypeptide binding]; other site 661367002549 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 661367002550 dimer interface [polypeptide binding]; other site 661367002551 active site 661367002552 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 661367002553 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 661367002554 active site 661367002555 tetramer interface; other site 661367002556 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 661367002557 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 661367002558 Permutation of conserved domain; other site 661367002559 active site 661367002560 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 661367002561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367002562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367002563 metal binding site [ion binding]; metal-binding site 661367002564 active site 661367002565 I-site; other site 661367002566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 661367002567 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 661367002568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002569 ATP binding site [chemical binding]; other site 661367002570 ATP binding site [chemical binding]; other site 661367002571 putative Mg++ binding site [ion binding]; other site 661367002572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002573 nucleotide binding region [chemical binding]; other site 661367002574 ATP-binding site [chemical binding]; other site 661367002575 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 661367002576 HRDC domain; Region: HRDC; pfam00570 661367002577 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 661367002578 active site 661367002579 DNA binding site [nucleotide binding] 661367002580 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367002581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367002582 active site 661367002583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367002584 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 661367002585 substrate binding site [chemical binding]; other site 661367002586 oxyanion hole (OAH) forming residues; other site 661367002587 trimer interface [polypeptide binding]; other site 661367002588 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 661367002589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367002590 substrate binding site [chemical binding]; other site 661367002591 oxyanion hole (OAH) forming residues; other site 661367002592 trimer interface [polypeptide binding]; other site 661367002593 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 661367002594 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 661367002595 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 661367002596 YGGT family; Region: YGGT; pfam02325 661367002597 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 661367002598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367002599 catalytic residue [active] 661367002600 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 661367002601 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 661367002602 Walker A motif; other site 661367002603 ATP binding site [chemical binding]; other site 661367002604 Walker B motif; other site 661367002605 GSCFA family; Region: GSCFA; pfam08885 661367002606 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367002607 Substrate binding site [chemical binding]; other site 661367002608 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367002609 Leucine-rich repeats; other site 661367002610 Substrate binding site [chemical binding]; other site 661367002611 ribonuclease PH; Reviewed; Region: rph; PRK00173 661367002612 Ribonuclease PH; Region: RNase_PH_bact; cd11362 661367002613 hexamer interface [polypeptide binding]; other site 661367002614 active site 661367002615 hypothetical protein; Provisional; Region: PRK11820 661367002616 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 661367002617 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 661367002618 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 661367002619 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 661367002620 catalytic site [active] 661367002621 G-X2-G-X-G-K; other site 661367002622 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 661367002623 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 661367002624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367002625 Zn2+ binding site [ion binding]; other site 661367002626 Mg2+ binding site [ion binding]; other site 661367002627 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 661367002628 synthetase active site [active] 661367002629 NTP binding site [chemical binding]; other site 661367002630 metal binding site [ion binding]; metal-binding site 661367002631 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 661367002632 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 661367002633 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 661367002634 homotrimer interaction site [polypeptide binding]; other site 661367002635 putative active site [active] 661367002636 ABC transporter ATPase component; Reviewed; Region: PRK11147 661367002637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367002639 Walker A/P-loop; other site 661367002640 ATP binding site [chemical binding]; other site 661367002641 Q-loop/lid; other site 661367002642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002643 ABC transporter signature motif; other site 661367002644 Walker B; other site 661367002645 D-loop; other site 661367002646 ABC transporter; Region: ABC_tran_2; pfam12848 661367002647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367002648 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 661367002649 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 661367002650 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 661367002651 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 661367002652 NMT1/THI5 like; Region: NMT1; pfam09084 661367002653 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 661367002654 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 661367002655 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 661367002656 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 661367002657 thiS-thiF/thiG interaction site; other site 661367002658 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 661367002659 ThiS interaction site; other site 661367002660 putative active site [active] 661367002661 tetramer interface [polypeptide binding]; other site 661367002662 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 661367002663 ATP binding site [chemical binding]; other site 661367002664 substrate binding site [chemical binding]; other site 661367002665 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 661367002666 thiamine phosphate binding site [chemical binding]; other site 661367002667 active site 661367002668 pyrophosphate binding site [ion binding]; other site 661367002669 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367002670 HSP70 interaction site [polypeptide binding]; other site 661367002671 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 661367002672 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 661367002673 [2Fe-2S] cluster binding site [ion binding]; other site 661367002674 hypothetical protein; Provisional; Region: PRK06849 661367002675 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367002676 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 661367002677 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 661367002678 ATP binding site [chemical binding]; other site 661367002679 substrate interface [chemical binding]; other site 661367002680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367002681 active site residue [active] 661367002682 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 661367002683 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 661367002684 Multicopper oxidase; Region: Cu-oxidase; pfam00394 661367002685 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 661367002686 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 661367002687 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 661367002688 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 661367002689 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 661367002690 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 661367002691 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 661367002692 Protein export membrane protein; Region: SecD_SecF; pfam02355 661367002693 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 661367002694 UbiA prenyltransferase family; Region: UbiA; pfam01040 661367002695 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 661367002696 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 661367002697 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 661367002698 NAD(P) binding site [chemical binding]; other site 661367002699 homodimer interface [polypeptide binding]; other site 661367002700 substrate binding site [chemical binding]; other site 661367002701 active site 661367002702 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 661367002703 dimer interface [polypeptide binding]; other site 661367002704 putative tRNA-binding site [nucleotide binding]; other site 661367002705 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 661367002706 Z1 domain; Region: Z1; pfam10593 661367002707 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 661367002708 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 661367002709 Helix-turn-helix domain; Region: HTH_17; cl17695 661367002710 Domain of unknown function (DUF927); Region: DUF927; pfam06048 661367002711 AAA ATPase domain; Region: AAA_15; pfam13175 661367002712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367002713 Walker A/P-loop; other site 661367002714 ATP binding site [chemical binding]; other site 661367002715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367002716 Walker B; other site 661367002717 D-loop; other site 661367002718 H-loop/switch region; other site 661367002719 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 661367002720 putative active site [active] 661367002721 putative metal-binding site [ion binding]; other site 661367002722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 661367002723 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 661367002724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367002725 ABC transporter signature motif; other site 661367002726 Walker B; other site 661367002727 D-loop; other site 661367002728 H-loop/switch region; other site 661367002729 Fic family protein [Function unknown]; Region: COG3177 661367002730 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 661367002731 Fic/DOC family; Region: Fic; pfam02661 661367002732 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367002733 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 661367002734 active site 661367002735 DNA binding site [nucleotide binding] 661367002736 Int/Topo IB signature motif; other site 661367002737 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367002738 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367002739 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367002740 DNA-binding site [nucleotide binding]; DNA binding site 661367002741 RNA-binding motif; other site 661367002742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002743 Ligand Binding Site [chemical binding]; other site 661367002744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002745 Ligand Binding Site [chemical binding]; other site 661367002746 putative cation:proton antiport protein; Provisional; Region: PRK10669 661367002747 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367002748 TrkA-N domain; Region: TrkA_N; pfam02254 661367002749 universal stress protein UspE; Provisional; Region: PRK11175 661367002750 Universal stress protein family; Region: Usp; pfam00582 661367002751 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002752 Ligand Binding Site [chemical binding]; other site 661367002753 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367002754 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 661367002755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367002756 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367002757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367002758 motif II; other site 661367002759 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367002760 Uncharacterized conserved protein [Function unknown]; Region: COG2128 661367002761 CAAX protease self-immunity; Region: Abi; cl00558 661367002762 BNR repeat-like domain; Region: BNR_2; pfam13088 661367002763 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 661367002764 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 661367002765 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 661367002766 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 661367002767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 661367002768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367002769 non-specific DNA binding site [nucleotide binding]; other site 661367002770 salt bridge; other site 661367002771 sequence-specific DNA binding site [nucleotide binding]; other site 661367002772 Cupin domain; Region: Cupin_2; cl17218 661367002773 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 661367002774 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367002775 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 661367002776 NAD(P) binding site [chemical binding]; other site 661367002777 Condensation domain; Region: Condensation; pfam00668 661367002778 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 661367002779 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 661367002780 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 661367002781 acyl-activating enzyme (AAE) consensus motif; other site 661367002782 AMP binding site [chemical binding]; other site 661367002783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367002784 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002785 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002786 active site 661367002787 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 661367002788 putative NADP binding site [chemical binding]; other site 661367002789 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 661367002790 active site 661367002791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367002792 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 661367002793 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002794 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002795 active site 661367002796 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367002797 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 661367002798 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 661367002799 Condensation domain; Region: Condensation; pfam00668 661367002800 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 661367002801 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 661367002802 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 661367002803 acyl-activating enzyme (AAE) consensus motif; other site 661367002804 AMP binding site [chemical binding]; other site 661367002805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367002806 Condensation domain; Region: Condensation; pfam00668 661367002807 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 661367002808 Nonribosomal peptide synthase; Region: NRPS; pfam08415 661367002809 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 661367002810 acyl-activating enzyme (AAE) consensus motif; other site 661367002811 AMP binding site [chemical binding]; other site 661367002812 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367002813 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 661367002814 putative FMN binding site [chemical binding]; other site 661367002815 NADPH bind site [chemical binding]; other site 661367002816 acyl-CoA synthetase; Validated; Region: PRK05850 661367002817 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 661367002818 acyl-activating enzyme (AAE) consensus motif; other site 661367002819 active site 661367002820 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 661367002821 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 661367002822 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 661367002823 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367002824 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367002825 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367002826 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 661367002827 Walker A/P-loop; other site 661367002828 ATP binding site [chemical binding]; other site 661367002829 Q-loop/lid; other site 661367002830 ABC transporter signature motif; other site 661367002831 Walker B; other site 661367002832 D-loop; other site 661367002833 H-loop/switch region; other site 661367002834 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 661367002835 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 661367002836 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 661367002837 Phosphotransferase enzyme family; Region: APH; pfam01636 661367002838 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 661367002839 Methyltransferase domain; Region: Methyltransf_23; pfam13489 661367002840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002841 S-adenosylmethionine binding site [chemical binding]; other site 661367002842 RibD C-terminal domain; Region: RibD_C; cl17279 661367002843 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367002844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367002845 Q-loop/lid; other site 661367002846 ABC transporter signature motif; other site 661367002847 Walker B; other site 661367002848 D-loop; other site 661367002849 H-loop/switch region; other site 661367002850 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002851 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367002852 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cd00159 661367002853 GTPase interaction site; other site 661367002854 catalytic residue [active] 661367002855 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 661367002856 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 661367002857 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367002858 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367002859 active site 661367002860 oxyanion hole [active] 661367002861 catalytic triad [active] 661367002862 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 661367002863 RNase_H superfamily; Region: RNase_H_2; pfam13482 661367002864 Part of AAA domain; Region: AAA_19; pfam13245 661367002865 AAA domain; Region: AAA_11; pfam13086 661367002866 AAA domain; Region: AAA_12; pfam13087 661367002867 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 661367002868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367002869 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 661367002870 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 661367002871 Domain of unknown function DUF87; Region: DUF87; pfam01935 661367002872 AAA-like domain; Region: AAA_10; pfam12846 661367002873 Zonular occludens toxin (Zot); Region: Zot; cl17485 661367002874 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 661367002875 Ferritin-like domain; Region: Ferritin; pfam00210 661367002876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 661367002877 dinuclear metal binding motif [ion binding]; other site 661367002878 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 661367002879 nucleotide binding site [chemical binding]; other site 661367002880 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 661367002881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367002882 active site 661367002883 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 661367002884 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367002885 cyclase homology domain; Region: CHD; cd07302 661367002886 nucleotidyl binding site; other site 661367002887 metal binding site [ion binding]; metal-binding site 661367002888 dimer interface [polypeptide binding]; other site 661367002889 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 661367002890 catalytic core [active] 661367002891 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 661367002892 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 661367002893 active site 661367002894 Zn binding site [ion binding]; other site 661367002895 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 661367002896 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 661367002897 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 661367002898 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 661367002899 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 661367002900 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367002901 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 661367002902 substrate binding site [chemical binding]; other site 661367002903 multimerization interface [polypeptide binding]; other site 661367002904 ATP binding site [chemical binding]; other site 661367002905 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 661367002906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367002907 FeS/SAM binding site; other site 661367002908 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 661367002909 CoenzymeA binding site [chemical binding]; other site 661367002910 subunit interaction site [polypeptide binding]; other site 661367002911 PHB binding site; other site 661367002912 acylphosphatase; Provisional; Region: PRK14451 661367002913 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 661367002914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 661367002915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367002916 putative substrate translocation pore; other site 661367002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 661367002918 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 661367002919 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 661367002920 Peptidase family M48; Region: Peptidase_M48; pfam01435 661367002921 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 661367002922 catalytic motif [active] 661367002923 Zn binding site [ion binding]; other site 661367002924 RibD C-terminal domain; Region: RibD_C; cl17279 661367002925 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 661367002926 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 661367002927 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 661367002928 dimerization interface [polypeptide binding]; other site 661367002929 active site 661367002930 CTP synthetase; Validated; Region: pyrG; PRK05380 661367002931 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 661367002932 Catalytic site [active] 661367002933 active site 661367002934 UTP binding site [chemical binding]; other site 661367002935 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 661367002936 active site 661367002937 putative oxyanion hole; other site 661367002938 catalytic triad [active] 661367002939 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 661367002940 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 661367002941 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367002942 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002943 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002944 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367002945 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 661367002946 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 661367002947 NAD binding site [chemical binding]; other site 661367002948 homotetramer interface [polypeptide binding]; other site 661367002949 homodimer interface [polypeptide binding]; other site 661367002950 substrate binding site [chemical binding]; other site 661367002951 active site 661367002952 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 661367002953 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 661367002954 Sugar specificity; other site 661367002955 Pyrimidine base specificity; other site 661367002956 ATP-binding site [chemical binding]; other site 661367002957 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 661367002958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367002959 active site residue [active] 661367002960 Stem cell factor; Region: SCF; pfam02404 661367002961 Glutamate-cysteine ligase; Region: GshA; pfam08886 661367002962 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 661367002963 glutathione synthetase; Provisional; Region: PRK05246 661367002964 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 661367002965 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 661367002966 VacJ like lipoprotein; Region: VacJ; cl01073 661367002967 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 661367002968 putative active site [active] 661367002969 dimerization interface [polypeptide binding]; other site 661367002970 putative tRNAtyr binding site [nucleotide binding]; other site 661367002971 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 661367002972 TAP-like protein; Region: Abhydrolase_4; pfam08386 661367002973 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 661367002974 Part of AAA domain; Region: AAA_19; pfam13245 661367002975 Family description; Region: UvrD_C_2; pfam13538 661367002976 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 661367002977 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 661367002978 catalytic residues [active] 661367002979 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 661367002980 dimer interface [polypeptide binding]; other site 661367002981 motif 1; other site 661367002982 active site 661367002983 motif 2; other site 661367002984 motif 3; other site 661367002985 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 661367002986 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 661367002987 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 661367002988 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 661367002989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367002990 putative substrate translocation pore; other site 661367002991 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 661367002992 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 661367002993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367002994 dimer interface [polypeptide binding]; other site 661367002995 conserved gate region; other site 661367002996 ABC-ATPase subunit interface; other site 661367002997 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 661367002998 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 661367002999 Walker A/P-loop; other site 661367003000 ATP binding site [chemical binding]; other site 661367003001 Q-loop/lid; other site 661367003002 ABC transporter signature motif; other site 661367003003 Walker B; other site 661367003004 D-loop; other site 661367003005 H-loop/switch region; other site 661367003006 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 661367003007 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 661367003008 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 661367003009 acyl-activating enzyme (AAE) consensus motif; other site 661367003010 putative AMP binding site [chemical binding]; other site 661367003011 putative active site [active] 661367003012 putative CoA binding site [chemical binding]; other site 661367003013 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 661367003014 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 661367003015 active site 661367003016 catalytic residues [active] 661367003017 metal binding site [ion binding]; metal-binding site 661367003018 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 661367003019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367003020 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 661367003021 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 661367003022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 661367003023 carboxyltransferase (CT) interaction site; other site 661367003024 biotinylation site [posttranslational modification]; other site 661367003025 enoyl-CoA hydratase; Provisional; Region: PRK05995 661367003026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367003027 substrate binding site [chemical binding]; other site 661367003028 oxyanion hole (OAH) forming residues; other site 661367003029 trimer interface [polypeptide binding]; other site 661367003030 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 661367003031 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 661367003032 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 661367003033 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367003034 dimer interface [polypeptide binding]; other site 661367003035 active site 661367003036 isovaleryl-CoA dehydrogenase; Region: PLN02519 661367003037 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 661367003038 substrate binding site [chemical binding]; other site 661367003039 FAD binding site [chemical binding]; other site 661367003040 catalytic base [active] 661367003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367003042 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 661367003043 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 661367003044 quinone interaction residues [chemical binding]; other site 661367003045 active site 661367003046 catalytic residues [active] 661367003047 FMN binding site [chemical binding]; other site 661367003048 substrate binding site [chemical binding]; other site 661367003049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003050 Coenzyme A binding pocket [chemical binding]; other site 661367003051 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 661367003052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 661367003053 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 661367003054 Walker A/P-loop; other site 661367003055 ATP binding site [chemical binding]; other site 661367003056 Q-loop/lid; other site 661367003057 ABC transporter signature motif; other site 661367003058 Walker B; other site 661367003059 D-loop; other site 661367003060 H-loop/switch region; other site 661367003061 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 661367003062 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 661367003063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367003065 putative substrate translocation pore; other site 661367003066 S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499 661367003067 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 661367003068 NAD binding site [chemical binding]; other site 661367003069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367003070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367003071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367003072 dimerization interface [polypeptide binding]; other site 661367003073 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367003074 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 661367003075 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 661367003076 Walker A motif; other site 661367003077 Part of AAA domain; Region: AAA_19; pfam13245 661367003078 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 661367003079 Family description; Region: UvrD_C_2; pfam13538 661367003080 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 661367003081 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 661367003082 nucleotide binding site [chemical binding]; other site 661367003083 substrate binding site [chemical binding]; other site 661367003084 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 661367003085 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 661367003086 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 661367003087 active site 661367003088 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367003089 substrate binding site [chemical binding]; other site 661367003090 catalytic residues [active] 661367003091 dimer interface [polypeptide binding]; other site 661367003092 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 661367003093 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367003094 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367003095 putative active site [active] 661367003096 putative NTP binding site [chemical binding]; other site 661367003097 putative nucleic acid binding site [nucleotide binding]; other site 661367003098 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 661367003099 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 661367003100 dimer interface [polypeptide binding]; other site 661367003101 active site 661367003102 Schiff base residues; other site 661367003103 Family of unknown function (DUF490); Region: DUF490; pfam04357 661367003104 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 661367003105 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 661367003106 Surface antigen; Region: Bac_surface_Ag; pfam01103 661367003107 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 661367003108 MutS domain I; Region: MutS_I; pfam01624 661367003109 MutS domain II; Region: MutS_II; pfam05188 661367003110 MutS domain III; Region: MutS_III; pfam05192 661367003111 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 661367003112 Walker A/P-loop; other site 661367003113 ATP binding site [chemical binding]; other site 661367003114 Q-loop/lid; other site 661367003115 ABC transporter signature motif; other site 661367003116 Walker B; other site 661367003117 D-loop; other site 661367003118 H-loop/switch region; other site 661367003119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367003120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367003121 dimer interface [polypeptide binding]; other site 661367003122 phosphorylation site [posttranslational modification] 661367003123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003124 ATP binding site [chemical binding]; other site 661367003125 G-X-G motif; other site 661367003126 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 661367003127 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 661367003128 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367003129 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 661367003130 NAD(P) binding site [chemical binding]; other site 661367003131 catalytic residues [active] 661367003132 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 661367003133 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 661367003134 putative active site [active] 661367003135 metal binding site [ion binding]; metal-binding site 661367003136 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 661367003137 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 661367003138 catalytic triad [active] 661367003139 Competence-damaged protein; Region: CinA; pfam02464 661367003140 recombinase A; Provisional; Region: recA; PRK09354 661367003141 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 661367003142 hexamer interface [polypeptide binding]; other site 661367003143 Walker A motif; other site 661367003144 ATP binding site [chemical binding]; other site 661367003145 Walker B motif; other site 661367003146 recombination regulator RecX; Reviewed; Region: recX; PRK00117 661367003147 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 661367003148 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 661367003149 motif 1; other site 661367003150 active site 661367003151 motif 2; other site 661367003152 motif 3; other site 661367003153 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 661367003154 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 661367003155 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 661367003156 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 661367003157 conserved cys residue [active] 661367003158 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 661367003159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003160 NAD(P) binding site [chemical binding]; other site 661367003161 active site 661367003162 FAD binding domain; Region: FAD_binding_4; pfam01565 661367003163 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 661367003164 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 661367003165 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 661367003166 P-loop; other site 661367003167 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 661367003168 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 661367003169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367003170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367003171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367003172 DNA binding residues [nucleotide binding] 661367003173 peptide chain release factor 2; Validated; Region: prfB; PRK00578 661367003174 This domain is found in peptide chain release factors; Region: PCRF; smart00937 661367003175 RF-1 domain; Region: RF-1; pfam00472 661367003176 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 661367003177 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 661367003178 dimer interface [polypeptide binding]; other site 661367003179 putative anticodon binding site; other site 661367003180 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 661367003181 motif 1; other site 661367003182 active site 661367003183 motif 2; other site 661367003184 motif 3; other site 661367003185 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 661367003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367003187 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 661367003188 substrate binding pocket [chemical binding]; other site 661367003189 dimerization interface [polypeptide binding]; other site 661367003190 Protein kinase domain; Region: Pkinase; pfam00069 661367003191 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367003192 active site 661367003193 ATP binding site [chemical binding]; other site 661367003194 substrate binding site [chemical binding]; other site 661367003195 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367003196 substrate binding site [chemical binding]; other site 661367003197 activation loop (A-loop); other site 661367003198 activation loop (A-loop); other site 661367003199 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 661367003200 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 661367003201 active site 661367003202 zinc binding site [ion binding]; other site 661367003203 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 661367003204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367003205 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367003206 active site 661367003207 metal binding site [ion binding]; metal-binding site 661367003208 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003209 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003210 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003211 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367003212 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 661367003213 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367003214 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 661367003215 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 661367003216 malate dehydrogenase; Provisional; Region: PRK13529 661367003217 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367003218 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 661367003219 NAD(P) binding site [chemical binding]; other site 661367003220 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 661367003221 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367003222 Peptidase family M23; Region: Peptidase_M23; pfam01551 661367003223 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 661367003224 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367003225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367003226 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367003227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367003228 DNA binding residues [nucleotide binding] 661367003229 VirK protein; Region: VirK; pfam06903 661367003230 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 661367003231 hypothetical protein; Validated; Region: PRK00110 661367003232 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 661367003233 active site 661367003234 putative DNA-binding cleft [nucleotide binding]; other site 661367003235 dimer interface [polypeptide binding]; other site 661367003236 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 661367003237 RuvA N terminal domain; Region: RuvA_N; pfam01330 661367003238 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 661367003239 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 661367003240 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367003241 sensor protein QseC; Provisional; Region: PRK10337 661367003242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367003243 dimer interface [polypeptide binding]; other site 661367003244 phosphorylation site [posttranslational modification] 661367003245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003246 ATP binding site [chemical binding]; other site 661367003247 Mg2+ binding site [ion binding]; other site 661367003248 G-X-G motif; other site 661367003249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003250 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 661367003251 active site 661367003252 phosphorylation site [posttranslational modification] 661367003253 intermolecular recognition site; other site 661367003254 dimerization interface [polypeptide binding]; other site 661367003255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367003256 DNA binding site [nucleotide binding] 661367003257 intracellular septation protein A; Reviewed; Region: PRK00259 661367003258 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 661367003259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 661367003260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367003261 catalytic residue [active] 661367003262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367003263 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 661367003264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367003265 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 661367003266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 661367003267 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367003268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367003269 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 661367003270 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 661367003271 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 661367003272 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 661367003273 homodimer interface [polypeptide binding]; other site 661367003274 NADP binding site [chemical binding]; other site 661367003275 substrate binding site [chemical binding]; other site 661367003276 FimV N-terminal domain; Region: FimV_core; TIGR03505 661367003277 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 661367003278 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003279 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003280 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003281 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003282 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367003283 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 661367003284 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 661367003285 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 661367003286 dimerization interface 3.5A [polypeptide binding]; other site 661367003287 active site 661367003288 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 661367003289 active site 661367003290 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 661367003291 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 661367003292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003293 catalytic residue [active] 661367003294 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 661367003295 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 661367003296 substrate binding site [chemical binding]; other site 661367003297 active site 661367003298 catalytic residues [active] 661367003299 heterodimer interface [polypeptide binding]; other site 661367003300 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 661367003301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367003302 active site 661367003303 HIGH motif; other site 661367003304 nucleotide binding site [chemical binding]; other site 661367003305 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 661367003306 KMSKS motif; other site 661367003307 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 661367003308 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 661367003309 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 661367003310 active site 661367003311 HIGH motif; other site 661367003312 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 661367003313 KMSKS motif; other site 661367003314 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 661367003315 tRNA binding surface [nucleotide binding]; other site 661367003316 anticodon binding site; other site 661367003317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003318 putative substrate translocation pore; other site 661367003319 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 661367003320 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 661367003321 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367003322 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367003323 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367003324 GIY-YIG motif/motif A; other site 661367003325 putative active site [active] 661367003326 putative metal binding site [ion binding]; other site 661367003327 type II secretion system protein E; Region: type_II_gspE; TIGR02533 661367003328 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 661367003329 Walker A motif; other site 661367003330 ATP binding site [chemical binding]; other site 661367003331 Walker B motif; other site 661367003332 Sporulation related domain; Region: SPOR; pfam05036 661367003333 type II secretion system protein D; Region: type_II_gspD; TIGR02517 661367003334 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003335 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003336 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003337 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 661367003338 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 661367003339 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 661367003340 MutS2 family protein; Region: mutS2; TIGR01069 661367003341 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367003342 HSP70 interaction site [polypeptide binding]; other site 661367003343 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 661367003344 putative FMN binding site [chemical binding]; other site 661367003345 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 661367003346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 661367003347 GAF domain; Region: GAF; pfam01590 661367003348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 661367003349 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 661367003350 PAS domain; Region: PAS_9; pfam13426 661367003351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367003352 putative active site [active] 661367003353 heme pocket [chemical binding]; other site 661367003354 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367003355 cyclase homology domain; Region: CHD; cd07302 661367003356 nucleotidyl binding site; other site 661367003357 metal binding site [ion binding]; metal-binding site 661367003358 dimer interface [polypeptide binding]; other site 661367003359 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 661367003360 Penicillinase repressor; Region: Pencillinase_R; pfam03965 661367003361 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 661367003362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 661367003363 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 661367003364 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 661367003365 DNA binding residues [nucleotide binding] 661367003366 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 661367003367 dimer interface [polypeptide binding]; other site 661367003368 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 661367003369 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 661367003370 active site 661367003371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 661367003372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003373 Coenzyme A binding pocket [chemical binding]; other site 661367003374 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 661367003375 CoA-transferase family III; Region: CoA_transf_3; pfam02515 661367003376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003377 Coenzyme A binding pocket [chemical binding]; other site 661367003378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 661367003379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367003380 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 661367003381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367003382 ABC transporter; Region: ABC_tran_2; pfam12848 661367003383 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 661367003384 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367003385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 661367003386 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367003388 Walker A/P-loop; other site 661367003389 ATP binding site [chemical binding]; other site 661367003390 Q-loop/lid; other site 661367003391 ABC transporter signature motif; other site 661367003392 Walker B; other site 661367003393 D-loop; other site 661367003394 H-loop/switch region; other site 661367003395 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 661367003396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003397 Coenzyme A binding pocket [chemical binding]; other site 661367003398 Predicted transcriptional regulator [Transcription]; Region: COG2378 661367003399 HTH domain; Region: HTH_11; pfam08279 661367003400 WYL domain; Region: WYL; pfam13280 661367003401 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 661367003402 putative dimer interface [polypeptide binding]; other site 661367003403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367003404 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 661367003405 Phosphotransferase enzyme family; Region: APH; pfam01636 661367003406 putative active site [active] 661367003407 putative substrate binding site [chemical binding]; other site 661367003408 ATP binding site [chemical binding]; other site 661367003409 Phosphotransferase enzyme family; Region: APH; pfam01636 661367003410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003411 S-adenosylmethionine binding site [chemical binding]; other site 661367003412 Methyltransferase domain; Region: Methyltransf_23; pfam13489 661367003413 Cache domain; Region: Cache_1; pfam02743 661367003414 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367003415 cyclase homology domain; Region: CHD; cd07302 661367003416 nucleotidyl binding site; other site 661367003417 metal binding site [ion binding]; metal-binding site 661367003418 dimer interface [polypeptide binding]; other site 661367003419 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 661367003420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367003421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367003422 substrate binding pocket [chemical binding]; other site 661367003423 membrane-bound complex binding site; other site 661367003424 hinge residues; other site 661367003425 oxidative damage protection protein; Provisional; Region: PRK05408 661367003426 PilZ domain; Region: PilZ; pfam07238 661367003427 Ferredoxin [Energy production and conversion]; Region: COG1146 661367003428 4Fe-4S binding domain; Region: Fer4; cl02805 661367003429 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 661367003430 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 661367003431 DEAD/DEAH box helicase; Region: DEAD; pfam00270 661367003432 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 661367003433 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 661367003434 Glycoprotease family; Region: Peptidase_M22; pfam00814 661367003435 Trm112p-like protein; Region: Trm112p; cl01066 661367003436 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 661367003437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367003438 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 661367003439 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367003440 Calcium-activated chloride channel; Region: Anoctamin; pfam04547 661367003441 BolA-like protein; Region: BolA; cl00386 661367003442 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 661367003443 Pilin (bacterial filament); Region: Pilin; pfam00114 661367003444 6-phosphofructokinase; Provisional; Region: PRK14072 661367003445 active site 661367003446 ADP/pyrophosphate binding site [chemical binding]; other site 661367003447 dimerization interface [polypeptide binding]; other site 661367003448 allosteric effector site; other site 661367003449 fructose-1,6-bisphosphate binding site; other site 661367003450 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 661367003451 HAMP domain; Region: HAMP; pfam00672 661367003452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367003453 dimer interface [polypeptide binding]; other site 661367003454 phosphorylation site [posttranslational modification] 661367003455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003456 ATP binding site [chemical binding]; other site 661367003457 Mg2+ binding site [ion binding]; other site 661367003458 G-X-G motif; other site 661367003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003460 active site 661367003461 phosphorylation site [posttranslational modification] 661367003462 dimerization interface [polypeptide binding]; other site 661367003463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003464 active site 661367003465 phosphorylation site [posttranslational modification] 661367003466 intermolecular recognition site; other site 661367003467 dimerization interface [polypeptide binding]; other site 661367003468 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367003469 putative binding surface; other site 661367003470 active site 661367003471 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 661367003472 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 661367003473 HIGH motif; other site 661367003474 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 661367003475 active site 661367003476 KMSKS motif; other site 661367003477 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 661367003478 Beta-lactamase; Region: Beta-lactamase; pfam00144 661367003479 glutathionine S-transferase; Provisional; Region: PRK10542 661367003480 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 661367003481 C-terminal domain interface [polypeptide binding]; other site 661367003482 GSH binding site (G-site) [chemical binding]; other site 661367003483 dimer interface [polypeptide binding]; other site 661367003484 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 661367003485 dimer interface [polypeptide binding]; other site 661367003486 N-terminal domain interface [polypeptide binding]; other site 661367003487 substrate binding pocket (H-site) [chemical binding]; other site 661367003488 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 661367003489 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 661367003490 Protein of unknown function, DUF462; Region: DUF462; pfam04315 661367003491 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367003492 catalytic site [active] 661367003493 metal binding site [ion binding]; metal-binding site 661367003494 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 661367003495 nucleotide binding site [chemical binding]; other site 661367003496 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 661367003497 Cupin superfamily protein; Region: Cupin_4; pfam08007 661367003498 Cupin-like domain; Region: Cupin_8; pfam13621 661367003499 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 661367003500 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 661367003501 TrkA-N domain; Region: TrkA_N; pfam02254 661367003502 hypothetical protein; Provisional; Region: PRK01617 661367003503 SEC-C motif; Region: SEC-C; pfam02810 661367003504 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 661367003505 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 661367003506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003507 active site 661367003508 phosphorylation site [posttranslational modification] 661367003509 intermolecular recognition site; other site 661367003510 dimerization interface [polypeptide binding]; other site 661367003511 PAS domain S-box; Region: sensory_box; TIGR00229 661367003512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367003513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367003514 metal binding site [ion binding]; metal-binding site 661367003515 active site 661367003516 I-site; other site 661367003517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367003518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367003519 PAS domain; Region: PAS_9; pfam13426 661367003520 putative active site [active] 661367003521 heme pocket [chemical binding]; other site 661367003522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367003523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003524 ATP binding site [chemical binding]; other site 661367003525 Mg2+ binding site [ion binding]; other site 661367003526 G-X-G motif; other site 661367003527 FIST N domain; Region: FIST; pfam08495 661367003528 Uncharacterized conserved protein [Function unknown]; Region: COG3287 661367003529 FIST C domain; Region: FIST_C; pfam10442 661367003530 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367003531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367003532 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367003533 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 661367003534 Protein export membrane protein; Region: SecD_SecF; cl14618 661367003535 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 661367003536 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367003537 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 661367003538 active site 661367003539 homopentamer interface [polypeptide binding]; other site 661367003540 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 661367003541 active site 661367003542 homopentamer interface [polypeptide binding]; other site 661367003543 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 661367003544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367003545 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367003546 substrate binding pocket [chemical binding]; other site 661367003547 membrane-bound complex binding site; other site 661367003548 hinge residues; other site 661367003549 nucleotide binding region [chemical binding]; other site 661367003550 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 661367003551 ATP-binding site [chemical binding]; other site 661367003552 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 661367003553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367003554 Zn2+ binding site [ion binding]; other site 661367003555 Mg2+ binding site [ion binding]; other site 661367003556 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 661367003557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 661367003558 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 661367003559 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 661367003560 GspL periplasmic domain; Region: GspL_C; cl14909 661367003561 Transglycosylase SLT domain; Region: SLT_2; pfam13406 661367003562 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 661367003563 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367003564 GTP-binding protein LepA; Provisional; Region: PRK05433 661367003565 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 661367003566 G1 box; other site 661367003567 putative GEF interaction site [polypeptide binding]; other site 661367003568 GTP/Mg2+ binding site [chemical binding]; other site 661367003569 Switch I region; other site 661367003570 G2 box; other site 661367003571 G3 box; other site 661367003572 Switch II region; other site 661367003573 G4 box; other site 661367003574 G5 box; other site 661367003575 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 661367003576 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 661367003577 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 661367003578 signal peptidase I; Provisional; Region: PRK10861 661367003579 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 661367003580 Catalytic site [active] 661367003581 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 661367003582 ribonuclease III; Reviewed; Region: rnc; PRK00102 661367003583 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 661367003584 dimerization interface [polypeptide binding]; other site 661367003585 active site 661367003586 metal binding site [ion binding]; metal-binding site 661367003587 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 661367003588 dsRNA binding site [nucleotide binding]; other site 661367003589 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 661367003590 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367003591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367003592 Walker A/P-loop; other site 661367003593 ATP binding site [chemical binding]; other site 661367003594 Q-loop/lid; other site 661367003595 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367003596 ABC transporter signature motif; other site 661367003597 Walker B; other site 661367003598 D-loop; other site 661367003599 ABC transporter; Region: ABC_tran_2; pfam12848 661367003600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367003601 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367003602 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 661367003603 Int/Topo IB signature motif; other site 661367003604 trigger factor; Provisional; Region: tig; PRK01490 661367003605 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 661367003606 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 661367003607 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 661367003608 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 661367003609 oligomer interface [polypeptide binding]; other site 661367003610 active site residues [active] 661367003611 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 661367003612 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 661367003613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367003614 Walker A motif; other site 661367003615 ATP binding site [chemical binding]; other site 661367003616 Walker B motif; other site 661367003617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 661367003618 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 661367003619 Found in ATP-dependent protease La (LON); Region: LON; smart00464 661367003620 Found in ATP-dependent protease La (LON); Region: LON; smart00464 661367003621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367003622 Walker A motif; other site 661367003623 ATP binding site [chemical binding]; other site 661367003624 Walker B motif; other site 661367003625 arginine finger; other site 661367003626 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 661367003627 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367003628 IHF dimer interface [polypeptide binding]; other site 661367003629 IHF - DNA interface [nucleotide binding]; other site 661367003630 periplasmic folding chaperone; Provisional; Region: PRK10788 661367003631 SurA N-terminal domain; Region: SurA_N_3; cl07813 661367003632 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 661367003633 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 661367003634 Outer membrane lipoprotein; Region: YfiO; pfam13525 661367003635 recombination associated protein; Reviewed; Region: rdgC; PRK00321 661367003636 K+ potassium transporter; Region: K_trans; pfam02705 661367003637 PUA domain; Region: PUA; cl00607 661367003638 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 661367003639 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 661367003640 putative RNA binding site [nucleotide binding]; other site 661367003641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003642 S-adenosylmethionine binding site [chemical binding]; other site 661367003643 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 661367003644 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 661367003645 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 661367003646 metal binding site [ion binding]; metal-binding site 661367003647 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 661367003648 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 661367003649 substrate binding site [chemical binding]; other site 661367003650 glutamase interaction surface [polypeptide binding]; other site 661367003651 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 661367003652 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 661367003653 catalytic residues [active] 661367003654 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 661367003655 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 661367003656 putative active site [active] 661367003657 oxyanion strand; other site 661367003658 catalytic triad [active] 661367003659 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 661367003660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367003661 active site 661367003662 motif I; other site 661367003663 motif II; other site 661367003664 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 661367003665 putative active site pocket [active] 661367003666 4-fold oligomerization interface [polypeptide binding]; other site 661367003667 metal binding residues [ion binding]; metal-binding site 661367003668 3-fold/trimer interface [polypeptide binding]; other site 661367003669 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 661367003670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003672 homodimer interface [polypeptide binding]; other site 661367003673 catalytic residue [active] 661367003674 histidinol dehydrogenase; Region: hisD; TIGR00069 661367003675 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 661367003676 NAD binding site [chemical binding]; other site 661367003677 dimerization interface [polypeptide binding]; other site 661367003678 product binding site; other site 661367003679 substrate binding site [chemical binding]; other site 661367003680 zinc binding site [ion binding]; other site 661367003681 catalytic residues [active] 661367003682 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 661367003683 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 661367003684 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 661367003685 Trp repressor protein; Region: Trp_repressor; cl17266 661367003686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367003687 active site 661367003688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367003689 DNA-binding site [nucleotide binding]; DNA binding site 661367003690 RNA-binding motif; other site 661367003691 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 661367003692 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 661367003693 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 661367003694 putative active site [active] 661367003695 putative metal binding site [ion binding]; other site 661367003696 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 661367003697 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367003698 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367003699 Leucine-rich repeats; other site 661367003700 Substrate binding site [chemical binding]; other site 661367003701 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367003702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367003703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003704 putative substrate translocation pore; other site 661367003705 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 661367003706 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 661367003707 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 661367003708 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 661367003709 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 661367003710 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 661367003711 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 661367003712 active site 661367003713 catalytic site [active] 661367003714 tetramer interface [polypeptide binding]; other site 661367003715 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 661367003716 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 661367003717 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 661367003718 PhnA protein; Region: PhnA; pfam03831 661367003719 aspartate aminotransferase; Provisional; Region: PRK05764 661367003720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003722 homodimer interface [polypeptide binding]; other site 661367003723 catalytic residue [active] 661367003724 Chorismate mutase type II; Region: CM_2; smart00830 661367003725 Prephenate dehydratase; Region: PDT; pfam00800 661367003726 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 661367003727 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 661367003728 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 661367003729 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367003730 ATP binding site [chemical binding]; other site 661367003731 Mg++ binding site [ion binding]; other site 661367003732 motif III; other site 661367003733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367003734 nucleotide binding region [chemical binding]; other site 661367003735 ATP-binding site [chemical binding]; other site 661367003736 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 661367003737 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 661367003738 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367003739 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 661367003740 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 661367003741 putative active site [active] 661367003742 putative PHP Thumb interface [polypeptide binding]; other site 661367003743 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 661367003744 generic binding surface II; other site 661367003745 generic binding surface I; other site 661367003746 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 661367003747 ligand binding site [chemical binding]; other site 661367003748 flexible hinge region; other site 661367003749 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 661367003750 aromatic arch; other site 661367003751 DCoH dimer interaction site [polypeptide binding]; other site 661367003752 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 661367003753 DCoH tetramer interaction site [polypeptide binding]; other site 661367003754 substrate binding site [chemical binding]; other site 661367003755 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 661367003756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003758 homodimer interface [polypeptide binding]; other site 661367003759 catalytic residue [active] 661367003760 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 661367003761 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 661367003762 MltA specific insert domain; Region: MltA; smart00925 661367003763 3D domain; Region: 3D; pfam06725 661367003764 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 661367003765 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367003766 NodB motif; other site 661367003767 putative active site [active] 661367003768 putative catalytic site [active] 661367003769 putative Zn binding site [ion binding]; other site 661367003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367003772 putative substrate translocation pore; other site 661367003773 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 661367003774 substrate binding pocket [chemical binding]; other site 661367003775 catalytic residues [active] 661367003776 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 661367003777 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 661367003778 tetramer interface [polypeptide binding]; other site 661367003779 heme binding pocket [chemical binding]; other site 661367003780 NADPH binding site [chemical binding]; other site 661367003781 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367003782 active site clefts [active] 661367003783 zinc binding site [ion binding]; other site 661367003784 dimer interface [polypeptide binding]; other site 661367003785 pyruvate dehydrogenase; Provisional; Region: PRK09124 661367003786 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 661367003787 PYR/PP interface [polypeptide binding]; other site 661367003788 dimer interface [polypeptide binding]; other site 661367003789 tetramer interface [polypeptide binding]; other site 661367003790 TPP binding site [chemical binding]; other site 661367003791 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 661367003792 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 661367003793 TPP-binding site [chemical binding]; other site 661367003794 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367003795 Uncharacterized conserved protein [Function unknown]; Region: COG4278 661367003796 Predicted transcriptional regulators [Transcription]; Region: COG1733 661367003797 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 661367003798 multidrug efflux protein; Reviewed; Region: PRK01766 661367003799 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 661367003800 cation binding site [ion binding]; other site 661367003801 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003802 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003803 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003804 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367003805 NAD synthetase; Reviewed; Region: nadE; cl17435 661367003806 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 661367003807 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367003808 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 661367003809 active site 661367003810 HIGH motif; other site 661367003811 nucleotide binding site [chemical binding]; other site 661367003812 MASE1; Region: MASE1; pfam05231 661367003813 CHASE domain; Region: CHASE; cl01369 661367003814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367003815 PAS domain; Region: PAS_9; pfam13426 661367003816 putative active site [active] 661367003817 heme pocket [chemical binding]; other site 661367003818 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367003819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367003820 metal binding site [ion binding]; metal-binding site 661367003821 active site 661367003822 I-site; other site 661367003823 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 661367003824 mce related protein; Region: MCE; pfam02470 661367003825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 661367003826 Protein of unknown function (DUF330); Region: DUF330; pfam03886 661367003827 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 661367003828 active site 661367003829 catalytic residues [active] 661367003830 Zeta toxin; Region: Zeta_toxin; pfam06414 661367003831 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 661367003832 active site 661367003833 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 661367003834 GIY-YIG motif/motif A; other site 661367003835 putative active site [active] 661367003836 putative metal binding site [ion binding]; other site 661367003837 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 661367003838 diiron binding motif [ion binding]; other site 661367003839 tellurite resistance protein TehB; Provisional; Region: PRK12335 661367003840 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 661367003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003842 S-adenosylmethionine binding site [chemical binding]; other site 661367003843 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 661367003844 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 661367003845 Putative water exit pathway; other site 661367003846 Binuclear center (active site) [active] 661367003847 K-pathway; other site 661367003848 Putative proton exit pathway; other site 661367003849 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 661367003850 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367003851 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367003852 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 661367003853 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 661367003854 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003855 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003856 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003857 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003858 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003859 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 661367003860 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 661367003861 catalytic triad [active] 661367003862 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 661367003863 active site/putative ARF binding site [active] 661367003864 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367003865 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367003866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367003867 catalytic residue [active] 661367003868 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 661367003869 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 661367003870 PPR repeat family; Region: PPR_2; pfam13041 661367003871 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 661367003872 putative catalytic site [active] 661367003873 putative metal binding site [ion binding]; other site 661367003874 putative phosphate binding site [ion binding]; other site 661367003875 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 661367003876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003877 S-adenosylmethionine binding site [chemical binding]; other site 661367003878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003879 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367003880 putative substrate translocation pore; other site 661367003881 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367003882 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367003883 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 661367003884 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367003885 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 661367003886 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367003887 HSP70 interaction site [polypeptide binding]; other site 661367003888 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 661367003889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 661367003890 dimerization interface [polypeptide binding]; other site 661367003891 putative DNA binding site [nucleotide binding]; other site 661367003892 putative Zn2+ binding site [ion binding]; other site 661367003893 Double zinc ribbon; Region: DZR; pfam12773 661367003894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 661367003896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367003897 Walker A/P-loop; other site 661367003898 ATP binding site [chemical binding]; other site 661367003899 Q-loop/lid; other site 661367003900 ABC transporter signature motif; other site 661367003901 Walker B; other site 661367003902 D-loop; other site 661367003903 H-loop/switch region; other site 661367003904 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 661367003905 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 661367003906 putative ligand binding site [chemical binding]; other site 661367003907 putative NAD binding site [chemical binding]; other site 661367003908 catalytic site [active] 661367003909 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367003910 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 661367003911 putative di-iron ligands [ion binding]; other site 661367003912 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 661367003913 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367003914 ligand binding site [chemical binding]; other site 661367003915 flexible hinge region; other site 661367003916 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 661367003917 putative switch regulator; other site 661367003918 non-specific DNA interactions [nucleotide binding]; other site 661367003919 DNA binding site [nucleotide binding] 661367003920 sequence specific DNA binding site [nucleotide binding]; other site 661367003921 putative cAMP binding site [chemical binding]; other site 661367003922 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 661367003923 putative NAD(P) binding site [chemical binding]; other site 661367003924 homodimer interface [polypeptide binding]; other site 661367003925 MoxR-like ATPases [General function prediction only]; Region: COG0714 661367003926 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367003928 Walker A/P-loop; other site 661367003929 ATP binding site [chemical binding]; other site 661367003930 Q-loop/lid; other site 661367003931 ABC transporter signature motif; other site 661367003932 Walker B; other site 661367003933 D-loop; other site 661367003934 H-loop/switch region; other site 661367003935 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 661367003936 dimer interface [polypeptide binding]; other site 661367003937 putative radical transfer pathway; other site 661367003938 diiron center [ion binding]; other site 661367003939 tyrosyl radical; other site 661367003940 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 661367003941 ATP cone domain; Region: ATP-cone; pfam03477 661367003942 Class I ribonucleotide reductase; Region: RNR_I; cd01679 661367003943 active site 661367003944 dimer interface [polypeptide binding]; other site 661367003945 catalytic residues [active] 661367003946 effector binding site; other site 661367003947 R2 peptide binding site; other site 661367003948 Predicted periplasmic protein [Function unknown]; Region: COG3698 661367003949 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 661367003950 peptidase PmbA; Provisional; Region: PRK11040 661367003951 Sel1-like repeats; Region: SEL1; smart00671 661367003952 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367003953 Sel1-like repeats; Region: SEL1; smart00671 661367003954 Sel1-like repeats; Region: SEL1; smart00671 661367003955 Sel1-like repeats; Region: SEL1; smart00671 661367003956 Sel1 repeat; Region: Sel1; cl02723 661367003957 Sel1-like repeats; Region: SEL1; smart00671 661367003958 Sel1-like repeats; Region: SEL1; smart00671 661367003959 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 661367003960 type II secretion system protein J; Region: gspJ; TIGR01711 661367003961 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 661367003962 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 661367003963 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 661367003964 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 661367003965 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 661367003966 type II secretion system protein F; Region: GspF; TIGR02120 661367003967 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 661367003968 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 661367003969 glutamine synthetase; Provisional; Region: glnA; PRK09469 661367003970 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 661367003971 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 661367003972 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 661367003973 hypothetical protein; Validated; Region: PRK02101 661367003974 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 661367003975 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 661367003976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367003977 catalytic residue [active] 661367003978 heat shock protein 90; Provisional; Region: PRK05218 661367003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003980 ATP binding site [chemical binding]; other site 661367003981 Mg2+ binding site [ion binding]; other site 661367003982 G-X-G motif; other site 661367003983 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367003984 V-type ATP synthase subunit I; Validated; Region: PRK05771 661367003985 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367003986 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 661367003987 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 661367003988 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 661367003989 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367003990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 661367003991 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 661367003992 RNA/DNA hybrid binding site [nucleotide binding]; other site 661367003993 active site 661367003994 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 661367003995 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 661367003996 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 661367003997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 661367003998 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 661367003999 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 661367004000 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 661367004001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004002 putative substrate translocation pore; other site 661367004003 urocanate hydratase; Provisional; Region: PRK05414 661367004004 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 661367004005 active sites [active] 661367004006 tetramer interface [polypeptide binding]; other site 661367004007 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 661367004008 RNA/DNA hybrid binding site [nucleotide binding]; other site 661367004009 active site 661367004010 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 661367004011 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 661367004012 active site 661367004013 catalytic site [active] 661367004014 substrate binding site [chemical binding]; other site 661367004015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 661367004016 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367004017 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 661367004018 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 661367004019 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 661367004020 Ligand Binding Site [chemical binding]; other site 661367004021 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 661367004022 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 661367004023 putative phosphate acyltransferase; Provisional; Region: PRK05331 661367004024 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 661367004025 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367004026 dimer interface [polypeptide binding]; other site 661367004027 active site 661367004028 CoA binding pocket [chemical binding]; other site 661367004029 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 661367004030 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367004031 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 661367004032 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 661367004033 NAD(P) binding site [chemical binding]; other site 661367004034 homotetramer interface [polypeptide binding]; other site 661367004035 homodimer interface [polypeptide binding]; other site 661367004036 active site 661367004037 acyl carrier protein; Provisional; Region: acpP; PRK00982 661367004038 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367004039 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367004040 dimer interface [polypeptide binding]; other site 661367004041 active site 661367004042 YceG-like family; Region: YceG; pfam02618 661367004043 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 661367004044 dimerization interface [polypeptide binding]; other site 661367004045 thymidylate kinase; Validated; Region: tmk; PRK00698 661367004046 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 661367004047 TMP-binding site; other site 661367004048 ATP-binding site [chemical binding]; other site 661367004049 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 661367004050 DNA polymerase III subunit delta'; Validated; Region: PRK08485 661367004051 PilZ domain; Region: PilZ; cl01260 661367004052 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 661367004053 active site 661367004054 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 661367004055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367004056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004057 putative substrate translocation pore; other site 661367004058 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 661367004059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004060 putative substrate translocation pore; other site 661367004061 F-box domain; Region: F-box; pfam00646 661367004062 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 661367004063 Phosphotransferase enzyme family; Region: APH; pfam01636 661367004064 active site 661367004065 ATP binding site [chemical binding]; other site 661367004066 substrate binding site [chemical binding]; other site 661367004067 dimer interface [polypeptide binding]; other site 661367004068 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 661367004069 active site 661367004070 catalytic site [active] 661367004071 substrate binding site [chemical binding]; other site 661367004072 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 661367004073 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 661367004074 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367004075 catalytic residue [active] 661367004076 adenylate kinase; Reviewed; Region: adk; PRK00279 661367004077 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 661367004078 AMP-binding site [chemical binding]; other site 661367004079 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 661367004080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 661367004081 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 661367004082 catalytic residues [active] 661367004083 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 661367004084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367004085 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 661367004086 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 661367004087 N- and C-terminal domain interface [polypeptide binding]; other site 661367004088 active site 661367004089 MgATP binding site [chemical binding]; other site 661367004090 catalytic site [active] 661367004091 metal binding site [ion binding]; metal-binding site 661367004092 glycerol binding site [chemical binding]; other site 661367004093 homotetramer interface [polypeptide binding]; other site 661367004094 homodimer interface [polypeptide binding]; other site 661367004095 FBP binding site [chemical binding]; other site 661367004096 protein IIAGlc interface [polypeptide binding]; other site 661367004097 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 661367004098 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 661367004099 Uncharacterized conserved protein [Function unknown]; Region: COG2938 661367004100 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 661367004101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367004102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367004103 DNA binding residues [nucleotide binding] 661367004104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004105 S-adenosylmethionine binding site [chemical binding]; other site 661367004106 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367004107 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 661367004108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367004109 Walker A motif; other site 661367004110 ATP binding site [chemical binding]; other site 661367004111 Walker B motif; other site 661367004112 arginine finger; other site 661367004113 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 661367004114 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 661367004115 active site 661367004116 TolQ protein; Region: tolQ; TIGR02796 661367004117 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 661367004118 TolR protein; Region: tolR; TIGR02801 661367004119 TolA protein; Region: tolA_full; TIGR02794 661367004120 TolA protein; Region: tolA_full; TIGR02794 661367004121 TonB C terminal; Region: TonB_2; pfam13103 661367004122 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 661367004123 TolB amino-terminal domain; Region: TolB_N; pfam04052 661367004124 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367004125 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367004126 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367004127 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 661367004128 active site 661367004129 Zn binding site [ion binding]; other site 661367004130 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 661367004131 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367004132 E3 interaction surface; other site 661367004133 lipoyl attachment site [posttranslational modification]; other site 661367004134 e3 binding domain; Region: E3_binding; pfam02817 661367004135 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 661367004136 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 661367004137 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 661367004138 alpha subunit interface [polypeptide binding]; other site 661367004139 TPP binding site [chemical binding]; other site 661367004140 heterodimer interface [polypeptide binding]; other site 661367004141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367004142 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 661367004143 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 661367004144 TPP-binding site [chemical binding]; other site 661367004145 tetramer interface [polypeptide binding]; other site 661367004146 heterodimer interface [polypeptide binding]; other site 661367004147 phosphorylation loop region [posttranslational modification] 661367004148 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 661367004149 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 661367004150 chorismate binding enzyme; Region: Chorismate_bind; cl10555 661367004151 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 661367004152 putative active site [active] 661367004153 putative CoA binding site [chemical binding]; other site 661367004154 nudix motif; other site 661367004155 metal binding site [ion binding]; metal-binding site 661367004156 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 661367004157 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 661367004158 acyl-activating enzyme (AAE) consensus motif; other site 661367004159 putative AMP binding site [chemical binding]; other site 661367004160 putative active site [active] 661367004161 putative CoA binding site [chemical binding]; other site 661367004162 septum formation inhibitor; Reviewed; Region: minC; PRK04804 661367004163 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 661367004164 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 661367004165 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367004166 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 661367004167 putative active site [active] 661367004168 putative metal binding site [ion binding]; other site 661367004169 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 661367004170 active site 661367004171 dinuclear metal binding site [ion binding]; other site 661367004172 dimerization interface [polypeptide binding]; other site 661367004173 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 661367004174 active site 661367004175 multimer interface [polypeptide binding]; other site 661367004176 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 661367004177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367004178 FeS/SAM binding site; other site 661367004179 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 661367004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367004181 binding surface 661367004182 TPR motif; other site 661367004183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367004184 binding surface 661367004185 TPR motif; other site 661367004186 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 661367004187 Helix-turn-helix domain; Region: HTH_25; pfam13413 661367004188 non-specific DNA binding site [nucleotide binding]; other site 661367004189 salt bridge; other site 661367004190 sequence-specific DNA binding site [nucleotide binding]; other site 661367004191 histidyl-tRNA synthetase; Region: hisS; TIGR00442 661367004192 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 661367004193 dimer interface [polypeptide binding]; other site 661367004194 motif 1; other site 661367004195 active site 661367004196 motif 2; other site 661367004197 motif 3; other site 661367004198 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 661367004199 anticodon binding site; other site 661367004200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 661367004201 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 661367004202 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 661367004203 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 661367004204 Trp docking motif [polypeptide binding]; other site 661367004205 active site 661367004206 GTP-binding protein Der; Reviewed; Region: PRK00093 661367004207 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 661367004208 G1 box; other site 661367004209 GTP/Mg2+ binding site [chemical binding]; other site 661367004210 Switch I region; other site 661367004211 G2 box; other site 661367004212 Switch II region; other site 661367004213 G3 box; other site 661367004214 G4 box; other site 661367004215 G5 box; other site 661367004216 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 661367004217 G1 box; other site 661367004218 GTP/Mg2+ binding site [chemical binding]; other site 661367004219 Switch I region; other site 661367004220 G2 box; other site 661367004221 G3 box; other site 661367004222 Switch II region; other site 661367004223 G4 box; other site 661367004224 G5 box; other site 661367004225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367004226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367004227 ligand binding site [chemical binding]; other site 661367004228 flexible hinge region; other site 661367004229 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 661367004230 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367004231 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 661367004232 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 661367004233 putative active site [active] 661367004234 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 661367004235 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 661367004236 Walker A/P-loop; other site 661367004237 ATP binding site [chemical binding]; other site 661367004238 Q-loop/lid; other site 661367004239 ABC transporter signature motif; other site 661367004240 Walker B; other site 661367004241 D-loop; other site 661367004242 H-loop/switch region; other site 661367004243 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 661367004244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367004245 Walker A/P-loop; other site 661367004246 ATP binding site [chemical binding]; other site 661367004247 Q-loop/lid; other site 661367004248 ABC transporter signature motif; other site 661367004249 Walker B; other site 661367004250 D-loop; other site 661367004251 H-loop/switch region; other site 661367004252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 661367004253 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 661367004254 nucleophilic elbow; other site 661367004255 catalytic triad; other site 661367004256 TAP-like protein; Region: Abhydrolase_4; pfam08386 661367004257 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 661367004258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 661367004259 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367004260 Ligand Binding Site [chemical binding]; other site 661367004261 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 661367004262 catalytic center binding site [active] 661367004263 ATP binding site [chemical binding]; other site 661367004264 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 661367004265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367004266 active site 661367004267 NTP binding site [chemical binding]; other site 661367004268 metal binding triad [ion binding]; metal-binding site 661367004269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367004270 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 661367004271 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 661367004272 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 661367004273 Rubredoxin [Energy production and conversion]; Region: COG1773 661367004274 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 661367004275 iron binding site [ion binding]; other site 661367004276 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 661367004277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367004278 inhibitor-cofactor binding pocket; inhibition site 661367004279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004280 catalytic residue [active] 661367004281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004282 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 661367004283 POT family; Region: PTR2; cl17359 661367004284 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 661367004285 Uncharacterized conserved protein [Function unknown]; Region: COG4121 661367004286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367004287 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 661367004288 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 661367004289 tetramer interface [polypeptide binding]; other site 661367004290 active site 661367004291 Mg2+/Mn2+ binding site [ion binding]; other site 661367004292 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 661367004293 dimer interface [polypeptide binding]; other site 661367004294 Citrate synthase; Region: Citrate_synt; pfam00285 661367004295 active site 661367004296 citrylCoA binding site [chemical binding]; other site 661367004297 oxalacetate/citrate binding site [chemical binding]; other site 661367004298 coenzyme A binding site [chemical binding]; other site 661367004299 catalytic triad [active] 661367004300 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 661367004301 2-methylcitrate dehydratase; Region: prpD; TIGR02330 661367004302 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 661367004303 PEP synthetase regulatory protein; Provisional; Region: PRK05339 661367004304 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 661367004305 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 661367004306 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 661367004307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367004309 putative substrate translocation pore; other site 661367004310 Serine carboxypeptidase; Region: Peptidase_S10; pfam00450 661367004311 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367004312 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367004313 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 661367004314 putative NAD(P) binding site [chemical binding]; other site 661367004315 putative substrate binding site [chemical binding]; other site 661367004316 catalytic Zn binding site [ion binding]; other site 661367004317 structural Zn binding site [ion binding]; other site 661367004318 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367004319 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367004320 putative dimer interface [polypeptide binding]; other site 661367004321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367004322 active site residue [active] 661367004323 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 661367004324 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 661367004325 Multicopper oxidase; Region: Cu-oxidase; pfam00394 661367004326 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 661367004327 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 661367004328 FAD binding domain; Region: FAD_binding_3; pfam01494 661367004329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 661367004330 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 661367004331 active site 661367004332 catalytic tetrad [active] 661367004333 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367004334 classical (c) SDRs; Region: SDR_c; cd05233 661367004335 NAD(P) binding site [chemical binding]; other site 661367004336 active site 661367004337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004338 S-adenosylmethionine binding site [chemical binding]; other site 661367004339 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 661367004340 30S subunit binding site; other site 661367004341 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367004342 RNA binding site [nucleotide binding]; other site 661367004343 FOG: CBS domain [General function prediction only]; Region: COG0517 661367004344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 661367004345 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 661367004346 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 661367004347 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 661367004348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367004349 motif II; other site 661367004350 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 661367004351 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 661367004352 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 661367004353 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 661367004354 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 661367004355 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 661367004356 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 661367004357 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 661367004358 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 661367004359 Walker A motif; other site 661367004360 ATP binding site [chemical binding]; other site 661367004361 Walker B motif; other site 661367004362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367004363 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 661367004364 hypoxanthine-guanine phosphoribosyltransferase; Provisional; Region: PRK09162 661367004365 active site 661367004366 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 661367004367 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367004368 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367004369 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367004370 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367004371 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367004372 ligand binding site [chemical binding]; other site 661367004373 flexible hinge region; other site 661367004374 aminopeptidase N; Provisional; Region: pepN; PRK14015 661367004375 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 661367004376 Zn binding site [ion binding]; other site 661367004377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367004378 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 661367004379 hypothetical protein; Provisional; Region: PRK05208 661367004380 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367004381 GIY-YIG motif/motif A; other site 661367004382 putative active site [active] 661367004383 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 661367004384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 661367004385 nucleotide binding region [chemical binding]; other site 661367004386 ATP-binding site [chemical binding]; other site 661367004387 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 661367004388 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 661367004389 MG2 domain; Region: A2M_N; pfam01835 661367004390 Alpha-2-macroglobulin family; Region: A2M; pfam00207 661367004391 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 661367004392 surface patch; other site 661367004393 thioester region; other site 661367004394 specificity defining residues; other site 661367004395 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 661367004396 Transglycosylase; Region: Transgly; pfam00912 661367004397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 661367004398 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 661367004399 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 661367004400 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 661367004401 malonyl-CoA binding site [chemical binding]; other site 661367004402 dimer interface [polypeptide binding]; other site 661367004403 active site 661367004404 product binding site; other site 661367004405 Methyltransferase domain; Region: Methyltransf_31; pfam13847 661367004406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004407 S-adenosylmethionine binding site [chemical binding]; other site 661367004408 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 661367004409 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 661367004410 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367004411 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 661367004412 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 661367004413 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 661367004414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367004415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004416 catalytic residue [active] 661367004417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367004418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367004419 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367004420 putative effector binding pocket; other site 661367004421 dimerization interface [polypeptide binding]; other site 661367004422 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 661367004423 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 661367004424 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004425 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004426 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 661367004427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004428 DNA binding residues [nucleotide binding] 661367004429 dimerization interface [polypeptide binding]; other site 661367004430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004431 non-specific DNA binding site [nucleotide binding]; other site 661367004432 salt bridge; other site 661367004433 sequence-specific DNA binding site [nucleotide binding]; other site 661367004434 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 661367004435 multiple promoter invertase; Provisional; Region: mpi; PRK13413 661367004436 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 661367004437 catalytic residues [active] 661367004438 catalytic nucleophile [active] 661367004439 Presynaptic Site I dimer interface [polypeptide binding]; other site 661367004440 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 661367004441 Synaptic Flat tetramer interface [polypeptide binding]; other site 661367004442 Synaptic Site I dimer interface [polypeptide binding]; other site 661367004443 DNA binding site [nucleotide binding] 661367004444 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 661367004445 DNA-binding interface [nucleotide binding]; DNA binding site 661367004446 Restriction endonuclease; Region: Mrr_cat; pfam04471 661367004447 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 661367004448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367004449 Transposase domain (DUF772); Region: DUF772; pfam05598 661367004450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367004451 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 661367004452 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 661367004453 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 661367004454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004455 non-specific DNA binding site [nucleotide binding]; other site 661367004456 salt bridge; other site 661367004457 sequence-specific DNA binding site [nucleotide binding]; other site 661367004458 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 661367004459 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 661367004460 active site 661367004461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 661367004462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004463 DNA binding residues [nucleotide binding] 661367004464 dimerization interface [polypeptide binding]; other site 661367004465 Cupin domain; Region: Cupin_2; pfam07883 661367004466 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367004467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004468 S-adenosylmethionine binding site [chemical binding]; other site 661367004469 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 661367004470 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 661367004471 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004472 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367004473 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004474 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004475 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004476 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004477 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004478 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367004479 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004480 Protein required for attachment to host cells; Region: Host_attach; pfam10116 661367004481 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 661367004482 Domain of unknown function DUF21; Region: DUF21; pfam01595 661367004483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367004484 Transporter associated domain; Region: CorC_HlyC; smart01091 661367004485 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 661367004486 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 661367004487 classical (c) SDRs; Region: SDR_c; cd05233 661367004488 NAD(P) binding site [chemical binding]; other site 661367004489 active site 661367004490 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367004491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367004492 substrate binding pocket [chemical binding]; other site 661367004493 membrane-bound complex binding site; other site 661367004494 hinge residues; other site 661367004495 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367004496 Zeta toxin; Region: Zeta_toxin; pfam06414 661367004497 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 661367004498 Uncharacterized conserved protein [Function unknown]; Region: COG1912 661367004499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 661367004500 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 661367004501 active site 661367004502 catalytic tetrad [active] 661367004503 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367004504 amidase; Provisional; Region: PRK08137 661367004505 Amidase; Region: Amidase; cl11426 661367004506 formate dehydrogenase; Provisional; Region: PRK07574 661367004507 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 661367004508 dimerization interface [polypeptide binding]; other site 661367004509 ligand binding site [chemical binding]; other site 661367004510 NAD binding site [chemical binding]; other site 661367004511 catalytic site [active] 661367004512 Cache domain; Region: Cache_1; pfam02743 661367004513 HAMP domain; Region: HAMP; pfam00672 661367004514 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367004515 cyclase homology domain; Region: CHD; cd07302 661367004516 nucleotidyl binding site; other site 661367004517 metal binding site [ion binding]; metal-binding site 661367004518 dimer interface [polypeptide binding]; other site 661367004519 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 661367004520 dimer interface [polypeptide binding]; other site 661367004521 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 661367004522 Amidase; Region: Amidase; cl11426 661367004523 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 661367004524 classical (c) SDRs; Region: SDR_c; cd05233 661367004525 NAD(P) binding site [chemical binding]; other site 661367004526 active site 661367004527 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 661367004528 Predicted transcriptional regulators [Transcription]; Region: COG1733 661367004529 DDE domain; Region: DDE_Tnp_IS240; pfam13610 661367004530 Integrase core domain; Region: rve; pfam00665 661367004531 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 661367004532 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367004533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367004534 active site 661367004535 ATP binding site [chemical binding]; other site 661367004536 substrate binding site [chemical binding]; other site 661367004537 activation loop (A-loop); other site 661367004538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367004539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367004540 active site 661367004541 ATP binding site [chemical binding]; other site 661367004542 substrate binding site [chemical binding]; other site 661367004543 activation loop (A-loop); other site 661367004544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004545 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367004546 putative substrate translocation pore; other site 661367004547 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 661367004548 putative DNA-binding cleft [nucleotide binding]; other site 661367004549 putative DNA clevage site; other site 661367004550 molecular lever; other site 661367004551 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 661367004552 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367004553 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367004554 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 661367004555 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 661367004556 dimer interface [polypeptide binding]; other site 661367004557 anticodon binding site; other site 661367004558 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 661367004559 homodimer interface [polypeptide binding]; other site 661367004560 motif 1; other site 661367004561 active site 661367004562 motif 2; other site 661367004563 GAD domain; Region: GAD; pfam02938 661367004564 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 661367004565 motif 3; other site 661367004566 Uncharacterized conserved protein [Function unknown]; Region: COG2928 661367004567 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 661367004568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 661367004569 PAS domain; Region: PAS_9; pfam13426 661367004570 Response regulator receiver domain; Region: Response_reg; pfam00072 661367004571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367004572 active site 661367004573 phosphorylation site [posttranslational modification] 661367004574 intermolecular recognition site; other site 661367004575 dimerization interface [polypeptide binding]; other site 661367004576 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367004577 short chain dehydrogenase; Provisional; Region: PRK05993 661367004578 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 661367004579 NADP binding site [chemical binding]; other site 661367004580 active site 661367004581 steroid binding site; other site 661367004582 aconitate hydratase; Validated; Region: PRK09277 661367004583 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367004584 substrate binding site [chemical binding]; other site 661367004585 ligand binding site [chemical binding]; other site 661367004586 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367004587 substrate binding site [chemical binding]; other site 661367004588 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367004589 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 661367004590 Proline dehydrogenase; Region: Pro_dh; pfam01619 661367004591 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 661367004592 Glutamate binding site [chemical binding]; other site 661367004593 NAD binding site [chemical binding]; other site 661367004594 catalytic residues [active] 661367004595 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367004596 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 661367004597 ProQ/FINO family; Region: ProQ; pfam04352 661367004598 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 661367004599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004600 S-adenosylmethionine binding site [chemical binding]; other site 661367004601 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 661367004602 ligand binding site [chemical binding]; other site 661367004603 active site 661367004604 hypothetical protein; Provisional; Region: PRK07338 661367004605 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 661367004606 metal binding site [ion binding]; metal-binding site 661367004607 dimer interface [polypeptide binding]; other site 661367004608 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 661367004609 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 661367004610 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 661367004611 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 661367004612 NAD(P) binding site [chemical binding]; other site 661367004613 catalytic residues [active] 661367004614 succinylarginine dihydrolase; Provisional; Region: PRK13281 661367004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367004616 outer membrane protease; Reviewed; Region: PRK10993 661367004617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004618 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367004619 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 661367004620 Rab subfamily motif 1 (RabSF1); other site 661367004621 G1 box; other site 661367004622 GTP/Mg2+ binding site [chemical binding]; other site 661367004623 Rab subfamily motif 2 (RabSF2); other site 661367004624 Switch I region; other site 661367004625 G2 box; other site 661367004626 effector interaction site; other site 661367004627 GDI interaction site; other site 661367004628 Rab family motif 1 (RabF1); other site 661367004629 GEF interaction site [polypeptide binding]; other site 661367004630 Rab family motif 2 (RabF2); other site 661367004631 G3 box; other site 661367004632 Switch II region; other site 661367004633 Rab family motif 3 (RabF3); other site 661367004634 Rab family motif 4 (RabF4); other site 661367004635 Rab family motif 5 (RabF5); other site 661367004636 Rab subfamily motif 3 (RabSF3); other site 661367004637 G4 box; other site 661367004638 G5 box; other site 661367004639 Rab subfamily motif 4 (RabSF4); other site 661367004640 ribosome recycling factor; Reviewed; Region: frr; PRK00083 661367004641 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 661367004642 hinge region; other site 661367004643 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 661367004644 putative nucleotide binding site [chemical binding]; other site 661367004645 uridine monophosphate binding site [chemical binding]; other site 661367004646 homohexameric interface [polypeptide binding]; other site 661367004647 elongation factor Ts; Provisional; Region: tsf; PRK09377 661367004648 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 661367004649 Elongation factor TS; Region: EF_TS; pfam00889 661367004650 Elongation factor TS; Region: EF_TS; pfam00889 661367004651 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 661367004652 rRNA interaction site [nucleotide binding]; other site 661367004653 S8 interaction site; other site 661367004654 putative laminin-1 binding site; other site 661367004655 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 661367004656 dimer interface [polypeptide binding]; other site 661367004657 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 661367004658 Uncharacterized conserved protein [Function unknown]; Region: COG2353 661367004659 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 661367004660 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 661367004661 AAA domain; Region: AAA_26; pfam13500 661367004662 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 661367004663 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 661367004664 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 661367004665 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 661367004666 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 661367004667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004668 catalytic residue [active] 661367004669 biotin synthase; Region: bioB; TIGR00433 661367004670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367004671 FeS/SAM binding site; other site 661367004672 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 661367004673 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367004674 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 661367004675 inhibitor-cofactor binding pocket; inhibition site 661367004676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004677 catalytic residue [active] 661367004678 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367004679 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 661367004680 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 661367004681 CoA-binding site [chemical binding]; other site 661367004682 ATP-binding [chemical binding]; other site 661367004683 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 661367004684 active site 661367004685 8-oxo-dGMP binding site [chemical binding]; other site 661367004686 nudix motif; other site 661367004687 metal binding site [ion binding]; metal-binding site 661367004688 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 661367004689 DEAD/DEAH box helicase; Region: DEAD; pfam00270 661367004690 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 661367004691 SEC-C motif; Region: SEC-C; pfam02810 661367004692 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 661367004693 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 661367004694 FMN binding site [chemical binding]; other site 661367004695 active site 661367004696 catalytic residues [active] 661367004697 substrate binding site [chemical binding]; other site 661367004698 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004699 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367004700 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004701 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004703 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 661367004704 DHH family; Region: DHH; pfam01368 661367004705 DHHA1 domain; Region: DHHA1; pfam02272 661367004706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 661367004707 aminotransferase; Validated; Region: PRK08175 661367004708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367004709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004710 homodimer interface [polypeptide binding]; other site 661367004711 catalytic residue [active] 661367004712 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 661367004713 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 661367004714 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367004715 active site 661367004716 nucleophile elbow; other site 661367004717 acetoacetate decarboxylase; Provisional; Region: PRK02265 661367004718 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 661367004719 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367004720 cyclase homology domain; Region: CHD; cd07302 661367004721 nucleotidyl binding site; other site 661367004722 metal binding site [ion binding]; metal-binding site 661367004723 dimer interface [polypeptide binding]; other site 661367004724 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367004725 active site 661367004726 GIY-YIG motif/motif A; other site 661367004727 catalytic site [active] 661367004728 metal binding site [ion binding]; metal-binding site 661367004729 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 661367004730 hypothetical protein; Provisional; Region: PRK05409 661367004731 YceI-like domain; Region: YceI; pfam04264 661367004732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 661367004733 HD domain; Region: HD_4; pfam13328 661367004734 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 661367004735 synthetase active site [active] 661367004736 NTP binding site [chemical binding]; other site 661367004737 metal binding site [ion binding]; metal-binding site 661367004738 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 661367004739 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 661367004740 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 661367004741 TRAM domain; Region: TRAM; pfam01938 661367004742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004743 S-adenosylmethionine binding site [chemical binding]; other site 661367004744 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 661367004745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367004746 Coenzyme A binding pocket [chemical binding]; other site 661367004747 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 661367004748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367004749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367004750 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367004751 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 661367004752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367004753 E3 interaction surface; other site 661367004754 lipoyl attachment site [posttranslational modification]; other site 661367004755 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367004756 E3 interaction surface; other site 661367004757 lipoyl attachment site [posttranslational modification]; other site 661367004758 e3 binding domain; Region: E3_binding; pfam02817 661367004759 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 661367004760 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 661367004761 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 661367004762 dimer interface [polypeptide binding]; other site 661367004763 TPP-binding site [chemical binding]; other site 661367004764 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 661367004765 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 661367004766 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367004767 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 661367004768 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 661367004769 Sporulation related domain; Region: SPOR; pfam05036 661367004770 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 661367004771 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 661367004772 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 661367004773 Protein of unknown function (DUF493); Region: DUF493; pfam04359 661367004774 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 661367004775 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 661367004776 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 661367004777 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 661367004778 active site 661367004779 LssY C-terminus; Region: LssY_C; pfam14067 661367004780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 661367004781 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 661367004782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367004783 RNA binding surface [nucleotide binding]; other site 661367004784 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 661367004785 probable active site [active] 661367004786 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 661367004787 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 661367004788 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 661367004789 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 661367004790 active site 661367004791 HIGH motif; other site 661367004792 dimer interface [polypeptide binding]; other site 661367004793 KMSKS motif; other site 661367004794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367004795 active site 661367004796 KMSKS motif; other site 661367004797 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 661367004798 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 661367004799 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 661367004800 active site 661367004801 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 661367004802 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 661367004803 PhoH-like protein; Region: PhoH; pfam02562 661367004804 metal-binding heat shock protein; Provisional; Region: PRK00016 661367004805 FOG: CBS domain [General function prediction only]; Region: COG0517 661367004806 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367004807 Transporter associated domain; Region: CorC_HlyC; smart01091 661367004808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367004809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367004810 active site 661367004811 phosphorylation site [posttranslational modification] 661367004812 intermolecular recognition site; other site 661367004813 dimerization interface [polypeptide binding]; other site 661367004814 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367004815 DNA binding site [nucleotide binding] 661367004816 two-component sensor protein; Provisional; Region: cpxA; PRK09470 661367004817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 661367004818 dimerization interface [polypeptide binding]; other site 661367004819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367004820 dimer interface [polypeptide binding]; other site 661367004821 phosphorylation site [posttranslational modification] 661367004822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367004823 ATP binding site [chemical binding]; other site 661367004824 Mg2+ binding site [ion binding]; other site 661367004825 G-X-G motif; other site 661367004826 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 661367004827 active site 661367004828 catalytic motif [active] 661367004829 Zn binding site [ion binding]; other site 661367004830 purine nucleoside phosphorylase; Provisional; Region: PRK08202 661367004831 Class I aldolases; Region: Aldolase_Class_I; cl17187 661367004832 catalytic residue [active] 661367004833 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 661367004834 UbiA prenyltransferase family; Region: UbiA; pfam01040 661367004835 Chorismate lyase; Region: Chor_lyase; cl01230 661367004836 Type II transport protein GspH; Region: GspH; pfam12019 661367004837 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 661367004838 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 661367004839 active site 661367004840 nucleophile elbow; other site 661367004841 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 661367004842 active site 661367004843 dimer interface [polypeptide binding]; other site 661367004844 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 661367004845 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 661367004846 inhibitor-cofactor binding pocket; inhibition site 661367004847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004848 catalytic residue [active] 661367004849 tetratricopeptide repeat protein; Provisional; Region: PRK11788 661367004850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367004851 TPR motif; other site 661367004852 binding surface 661367004853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367004854 binding surface 661367004855 TPR motif; other site 661367004856 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 661367004857 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 661367004858 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 661367004859 RNA binding site [nucleotide binding]; other site 661367004860 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 661367004861 RNA binding site [nucleotide binding]; other site 661367004862 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 661367004863 RNA binding site [nucleotide binding]; other site 661367004864 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367004865 RNA binding site [nucleotide binding]; other site 661367004866 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367004867 RNA binding site [nucleotide binding]; other site 661367004868 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 661367004869 RNA binding site [nucleotide binding]; other site 661367004870 cytidylate kinase; Provisional; Region: cmk; PRK00023 661367004871 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 661367004872 CMP-binding site; other site 661367004873 The sites determining sugar specificity; other site 661367004874 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 661367004875 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 661367004876 hinge; other site 661367004877 active site 661367004878 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 661367004879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004880 catalytic residue [active] 661367004881 DNA gyrase subunit A; Validated; Region: PRK05560 661367004882 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 661367004883 CAP-like domain; other site 661367004884 active site 661367004885 primary dimer interface [polypeptide binding]; other site 661367004886 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004887 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004888 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004889 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004890 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004891 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 661367004892 dimer interface [polypeptide binding]; other site 661367004893 Citrate synthase; Region: Citrate_synt; pfam00285 661367004894 active site 661367004895 citrylCoA binding site [chemical binding]; other site 661367004896 NADH binding [chemical binding]; other site 661367004897 cationic pore residues; other site 661367004898 oxalacetate/citrate binding site [chemical binding]; other site 661367004899 coenzyme A binding site [chemical binding]; other site 661367004900 catalytic triad [active] 661367004901 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 661367004902 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 661367004903 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 661367004904 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 661367004905 NAD(P) binding site [chemical binding]; other site 661367004906 catalytic residues [active] 661367004907 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 661367004908 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 661367004909 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 661367004910 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 661367004911 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 661367004912 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 661367004913 Global regulator protein family; Region: CsrA; pfam02599 661367004914 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 661367004915 active site 661367004916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 661367004917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367004918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367004919 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 661367004920 substrate binding site [chemical binding]; other site 661367004921 oxyanion hole (OAH) forming residues; other site 661367004922 trimer interface [polypeptide binding]; other site 661367004923 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 661367004924 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 661367004925 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 661367004926 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367004927 dimer interface [polypeptide binding]; other site 661367004928 active site 661367004929 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 661367004930 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367004931 active site 661367004932 DNA binding site [nucleotide binding] 661367004933 Int/Topo IB signature motif; other site 661367004934 Helix-turn-helix domain; Region: HTH_17; pfam12728 661367004935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004936 DNA binding residues [nucleotide binding] 661367004937 dimerization interface [polypeptide binding]; other site 661367004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004939 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367004940 putative substrate translocation pore; other site 661367004941 Methyltransferase domain; Region: Methyltransf_31; pfam13847 661367004942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004943 S-adenosylmethionine binding site [chemical binding]; other site 661367004944 Methyltransferase domain; Region: Methyltransf_23; pfam13489 661367004945 Methyltransferase domain; Region: Methyltransf_12; pfam08242 661367004946 S-adenosylmethionine binding site [chemical binding]; other site 661367004947 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 661367004948 iron binding site [ion binding]; other site 661367004949 TrwC relaxase; Region: TrwC; pfam08751 661367004950 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 661367004951 AAA domain; Region: AAA_30; pfam13604 661367004952 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 661367004953 F sex factor protein N terminal; Region: TraD_N; pfam12615 661367004954 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367004955 Walker A motif; other site 661367004956 ATP binding site [chemical binding]; other site 661367004957 Walker B motif; other site 661367004958 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 661367004959 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 661367004960 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 661367004961 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 661367004962 F plasmid transfer operon protein; Region: TraF; pfam13728 661367004963 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 661367004964 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 661367004965 TraU protein; Region: TraU; cl06067 661367004966 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 661367004967 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515 661367004968 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 661367004969 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 661367004970 Domain of unknown function DUF87; Region: DUF87; pfam01935 661367004971 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 661367004972 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 661367004973 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 661367004974 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 661367004975 TraK protein; Region: TraK; pfam06586 661367004976 TraE protein; Region: TraE; pfam05309 661367004977 TraL protein; Region: TraL; cl06278 661367004978 Global regulator protein family; Region: CsrA; pfam02599 661367004979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004980 non-specific DNA binding site [nucleotide binding]; other site 661367004981 salt bridge; other site 661367004982 sequence-specific DNA binding site [nucleotide binding]; other site 661367004983 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367004984 Catalytic site [active] 661367004985 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 661367004986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367004987 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 661367004988 catalytic site [active] 661367004989 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 661367004990 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 661367004991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 661367004992 DEAD_2; Region: DEAD_2; pfam06733 661367004993 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 661367004994 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 661367004995 active site 661367004996 catalytic site [active] 661367004997 substrate binding site [chemical binding]; other site 661367004998 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 661367004999 GIY-YIG motif/motif A; other site 661367005000 active site 661367005001 catalytic site [active] 661367005002 putative DNA binding site [nucleotide binding]; other site 661367005003 metal binding site [ion binding]; metal-binding site 661367005004 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367005005 active site 661367005006 DNA polymerase IV; Validated; Region: PRK02406 661367005007 DNA binding site [nucleotide binding] 661367005008 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367005009 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367005010 active site 661367005011 DNA binding site [nucleotide binding] 661367005012 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367005013 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367005014 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367005015 Catalytic site [active] 661367005016 Uncharacterized conserved protein [Function unknown]; Region: COG2135 661367005017 Predicted acetyltransferase [General function prediction only]; Region: COG2388 661367005018 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 661367005019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367005020 Ligand Binding Site [chemical binding]; other site 661367005021 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367005022 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367005023 putative active site [active] 661367005024 putative NTP binding site [chemical binding]; other site 661367005025 putative nucleic acid binding site [nucleotide binding]; other site 661367005026 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 661367005027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 661367005028 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 661367005029 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367005030 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367005031 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367005032 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 661367005033 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 661367005034 active site 661367005035 dimer interface [polypeptide binding]; other site 661367005036 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 661367005037 Ligand Binding Site [chemical binding]; other site 661367005038 Molecular Tunnel; other site 661367005039 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 661367005040 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 661367005041 putative active site [active] 661367005042 Zn binding site [ion binding]; other site 661367005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367005045 putative substrate translocation pore; other site 661367005046 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367005047 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367005048 putative active site [active] 661367005049 putative NTP binding site [chemical binding]; other site 661367005050 putative nucleic acid binding site [nucleotide binding]; other site 661367005051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367005052 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 661367005053 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367005054 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367005055 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 661367005056 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 661367005057 Cl- selectivity filter; other site 661367005058 Cl- binding residues [ion binding]; other site 661367005059 pore gating glutamate residue; other site 661367005060 dimer interface [polypeptide binding]; other site 661367005061 H+/Cl- coupling transport residue; other site 661367005062 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 661367005063 Immunoglobulin I-set domain; Region: I-set; pfam07679 661367005064 Immunoglobulin; Region: IG; smart00409 661367005065 Fn3 associated; Region: Fn3_assoc; pfam13287 661367005066 Immunoglobulin I-set domain; Region: I-set; pfam07679 661367005067 Immunoglobulin domain; Region: Ig_2; pfam13895 661367005068 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 661367005069 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 661367005070 Asp-box motif; other site 661367005071 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 661367005072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 661367005073 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367005074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367005075 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367005076 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367005077 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367005078 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367005079 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005080 ligand binding site [chemical binding]; other site 661367005081 CAAX protease self-immunity; Region: Abi; pfam02517 661367005082 Zeta toxin; Region: Zeta_toxin; pfam06414 661367005083 TROVE domain; Region: TROVE; pfam05731 661367005084 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 661367005085 Cupin domain; Region: Cupin_2; cl17218 661367005086 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367005087 MepB protein; Region: MepB; cl01985 661367005088 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367005089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 661367005090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 661367005091 elongation factor G; Reviewed; Region: PRK00007 661367005092 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 661367005093 G1 box; other site 661367005094 putative GEF interaction site [polypeptide binding]; other site 661367005095 GTP/Mg2+ binding site [chemical binding]; other site 661367005096 Switch I region; other site 661367005097 G2 box; other site 661367005098 G3 box; other site 661367005099 Switch II region; other site 661367005100 G4 box; other site 661367005101 G5 box; other site 661367005102 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 661367005103 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 661367005104 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 661367005105 RES domain; Region: RES; smart00953 661367005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 661367005107 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 661367005108 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 661367005109 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367005110 YCII-related domain; Region: YCII; cl00999 661367005111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 661367005112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005113 dimer interface [polypeptide binding]; other site 661367005114 conserved gate region; other site 661367005115 putative PBP binding loops; other site 661367005116 ABC-ATPase subunit interface; other site 661367005117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 661367005118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005119 dimer interface [polypeptide binding]; other site 661367005120 putative PBP binding loops; other site 661367005121 ABC-ATPase subunit interface; other site 661367005122 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 661367005123 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 661367005124 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 661367005125 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 661367005126 nucleotide binding pocket [chemical binding]; other site 661367005127 K-X-D-G motif; other site 661367005128 catalytic site [active] 661367005129 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 661367005130 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 661367005131 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 661367005132 Dimer interface [polypeptide binding]; other site 661367005133 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 661367005134 RmuC family; Region: RmuC; pfam02646 661367005135 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367005136 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367005137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 661367005138 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 661367005139 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 661367005140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367005141 ATP binding site [chemical binding]; other site 661367005142 putative Mg++ binding site [ion binding]; other site 661367005143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367005144 nucleotide binding region [chemical binding]; other site 661367005145 ATP-binding site [chemical binding]; other site 661367005146 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 661367005147 protease TldD; Provisional; Region: tldD; PRK10735 661367005148 nitrilase; Region: PLN02798 661367005149 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 661367005150 putative active site [active] 661367005151 catalytic triad [active] 661367005152 dimer interface [polypeptide binding]; other site 661367005153 YccA-like proteins; Region: YccA_like; cd10433 661367005154 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 661367005155 PAS fold; Region: PAS; pfam00989 661367005156 PAS domain; Region: PAS; smart00091 661367005157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367005158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367005159 metal binding site [ion binding]; metal-binding site 661367005160 active site 661367005161 I-site; other site 661367005162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367005163 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 661367005164 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 661367005165 TPP-binding site [chemical binding]; other site 661367005166 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 661367005167 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 661367005168 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 661367005169 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 661367005170 dimer interface [polypeptide binding]; other site 661367005171 PYR/PP interface [polypeptide binding]; other site 661367005172 TPP binding site [chemical binding]; other site 661367005173 substrate binding site [chemical binding]; other site 661367005174 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 661367005175 active site 661367005176 hydrophilic channel; other site 661367005177 dimerization interface [polypeptide binding]; other site 661367005178 catalytic residues [active] 661367005179 active site lid [active] 661367005180 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 661367005181 Recombination protein O N terminal; Region: RecO_N; pfam11967 661367005182 Recombination protein O C terminal; Region: RecO_C; pfam02565 661367005183 GTPase Era; Reviewed; Region: era; PRK00089 661367005184 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 661367005185 G1 box; other site 661367005186 GTP/Mg2+ binding site [chemical binding]; other site 661367005187 Switch I region; other site 661367005188 G2 box; other site 661367005189 Switch II region; other site 661367005190 G3 box; other site 661367005191 G4 box; other site 661367005192 G5 box; other site 661367005193 KH domain; Region: KH_2; pfam07650 661367005194 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367005195 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 661367005196 active site 661367005197 intersubunit interface [polypeptide binding]; other site 661367005198 catalytic residue [active] 661367005199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367005201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367005202 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 661367005203 lipoprotein signal peptidase; Provisional; Region: PRK14787 661367005204 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 661367005205 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367005206 active site 661367005207 HIGH motif; other site 661367005208 nucleotide binding site [chemical binding]; other site 661367005209 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367005210 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 661367005211 active site 661367005212 KMSKS motif; other site 661367005213 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 661367005214 tRNA binding surface [nucleotide binding]; other site 661367005215 anticodon binding site; other site 661367005216 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 661367005217 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 661367005218 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 661367005219 active site 661367005220 Riboflavin kinase; Region: Flavokinase; smart00904 661367005221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367005222 Ligand Binding Site [chemical binding]; other site 661367005223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367005224 binding surface 661367005225 TPR motif; other site 661367005226 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 661367005227 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 661367005228 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 661367005229 catalytic residues [active] 661367005230 central insert; other site 661367005231 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 661367005232 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 661367005233 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 661367005234 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 661367005235 heme exporter protein CcmB; Region: ccmB; TIGR01190 661367005236 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 661367005237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367005238 Walker A/P-loop; other site 661367005239 ATP binding site [chemical binding]; other site 661367005240 Q-loop/lid; other site 661367005241 ABC transporter signature motif; other site 661367005242 Walker B; other site 661367005243 D-loop; other site 661367005244 H-loop/switch region; other site 661367005245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 661367005246 Transposase; Region: HTH_Tnp_1; pfam01527 661367005247 putative transposase OrfB; Reviewed; Region: PHA02517 661367005248 HTH-like domain; Region: HTH_21; pfam13276 661367005249 Integrase core domain; Region: rve; pfam00665 661367005250 Integrase core domain; Region: rve_3; pfam13683 661367005251 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 661367005252 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 661367005253 putative active site [active] 661367005254 metal binding site [ion binding]; metal-binding site 661367005255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367005257 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367005258 putative effector binding pocket; other site 661367005259 dimerization interface [polypeptide binding]; other site 661367005260 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 661367005261 Zn binding site [ion binding]; other site 661367005262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005263 active site 661367005264 ATP binding site [chemical binding]; other site 661367005265 substrate binding site [chemical binding]; other site 661367005266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005267 substrate binding site [chemical binding]; other site 661367005268 activation loop (A-loop); other site 661367005269 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367005270 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367005271 active site 661367005272 DNA binding site [nucleotide binding] 661367005273 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367005274 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367005275 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367005276 Catalytic site [active] 661367005277 Uncharacterized conserved protein [Function unknown]; Region: COG2135 661367005278 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 661367005279 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 661367005280 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367005281 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367005282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367005283 catalytic residue [active] 661367005284 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367005285 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 661367005286 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367005287 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367005288 active site 661367005289 metal binding site [ion binding]; metal-binding site 661367005290 TspO/MBR family; Region: TspO_MBR; pfam03073 661367005291 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 661367005292 putative NAD(P) binding site [chemical binding]; other site 661367005293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367005294 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 661367005295 DNA photolyase; Region: DNA_photolyase; pfam00875 661367005296 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 661367005297 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 661367005298 Sensors of blue-light using FAD; Region: BLUF; pfam04940 661367005299 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 661367005300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005301 putative active site [active] 661367005302 heme pocket [chemical binding]; other site 661367005303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005304 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 661367005305 putative active site [active] 661367005306 heme pocket [chemical binding]; other site 661367005307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005308 putative active site [active] 661367005309 heme pocket [chemical binding]; other site 661367005310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367005311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367005312 metal binding site [ion binding]; metal-binding site 661367005313 active site 661367005314 I-site; other site 661367005315 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 661367005316 putative inner membrane peptidase; Provisional; Region: PRK11778 661367005317 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 661367005318 tandem repeat interface [polypeptide binding]; other site 661367005319 oligomer interface [polypeptide binding]; other site 661367005320 active site residues [active] 661367005321 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367005322 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 661367005323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005324 Walker A motif; other site 661367005325 ATP binding site [chemical binding]; other site 661367005326 Walker B motif; other site 661367005327 arginine finger; other site 661367005328 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 661367005329 Uncharacterized conserved protein [Function unknown]; Region: COG0327 661367005330 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 661367005331 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 661367005332 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 661367005333 hinge; other site 661367005334 active site 661367005335 BolA-like protein; Region: BolA; pfam01722 661367005336 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 661367005337 anti sigma factor interaction site; other site 661367005338 regulatory phosphorylation site [posttranslational modification]; other site 661367005339 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 661367005340 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 661367005341 mce related protein; Region: MCE; pfam02470 661367005342 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 661367005343 Permease; Region: Permease; cl00510 661367005344 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 661367005345 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 661367005346 Walker A/P-loop; other site 661367005347 ATP binding site [chemical binding]; other site 661367005348 Q-loop/lid; other site 661367005349 ABC transporter signature motif; other site 661367005350 Walker B; other site 661367005351 D-loop; other site 661367005352 H-loop/switch region; other site 661367005353 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 661367005354 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 661367005355 putative active site [active] 661367005356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 661367005357 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 661367005358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005359 active site 661367005360 motif I; other site 661367005361 motif II; other site 661367005362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 661367005363 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 661367005364 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 661367005365 OstA-like protein; Region: OstA; pfam03968 661367005366 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 661367005367 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 661367005368 Walker A/P-loop; other site 661367005369 ATP binding site [chemical binding]; other site 661367005370 Q-loop/lid; other site 661367005371 ABC transporter signature motif; other site 661367005372 Walker B; other site 661367005373 D-loop; other site 661367005374 H-loop/switch region; other site 661367005375 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 661367005376 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 661367005377 glutamine binding [chemical binding]; other site 661367005378 catalytic triad [active] 661367005379 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 661367005380 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 661367005381 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 661367005382 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 661367005383 active site 661367005384 ribulose/triose binding site [chemical binding]; other site 661367005385 phosphate binding site [ion binding]; other site 661367005386 substrate (anthranilate) binding pocket [chemical binding]; other site 661367005387 product (indole) binding pocket [chemical binding]; other site 661367005388 hypothetical protein; Provisional; Region: PRK06194 661367005389 classical (c) SDRs; Region: SDR_c; cd05233 661367005390 NAD(P) binding site [chemical binding]; other site 661367005391 active site 661367005392 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 661367005393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 661367005394 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 661367005395 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 661367005396 generic binding surface II; other site 661367005397 generic binding surface I; other site 661367005398 Rhomboid family; Region: Rhomboid; cl11446 661367005399 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 661367005400 dimer interface [polypeptide binding]; other site 661367005401 substrate binding site [chemical binding]; other site 661367005402 ATP binding site [chemical binding]; other site 661367005403 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 661367005404 O-Antigen ligase; Region: Wzy_C; pfam04932 661367005405 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 661367005406 putative metal binding site; other site 661367005407 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 661367005408 Clp amino terminal domain; Region: Clp_N; pfam02861 661367005409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005410 Walker A motif; other site 661367005411 ATP binding site [chemical binding]; other site 661367005412 Walker B motif; other site 661367005413 arginine finger; other site 661367005414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005415 Walker A motif; other site 661367005416 ATP binding site [chemical binding]; other site 661367005417 Walker B motif; other site 661367005418 arginine finger; other site 661367005419 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 661367005420 Uncharacterized conserved protein [Function unknown]; Region: COG2127 661367005421 isocitrate dehydrogenase; Validated; Region: PRK07362 661367005422 isocitrate dehydrogenase; Reviewed; Region: PRK07006 661367005423 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 661367005424 pseudouridine synthase; Region: TIGR00093 661367005425 active site 661367005426 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 661367005427 rod shape-determining protein MreC; Provisional; Region: PRK13922 661367005428 rod shape-determining protein MreC; Region: MreC; pfam04085 661367005429 rod shape-determining protein MreB; Provisional; Region: PRK13927 661367005430 MreB and similar proteins; Region: MreB_like; cd10225 661367005431 nucleotide binding site [chemical binding]; other site 661367005432 Mg binding site [ion binding]; other site 661367005433 putative protofilament interaction site [polypeptide binding]; other site 661367005434 RodZ interaction site [polypeptide binding]; other site 661367005435 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 661367005436 hypothetical protein; Provisional; Region: PRK08201 661367005437 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 661367005438 metal binding site [ion binding]; metal-binding site 661367005439 putative dimer interface [polypeptide binding]; other site 661367005440 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 661367005441 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 661367005442 active site 661367005443 homodimer interface [polypeptide binding]; other site 661367005444 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 661367005445 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 661367005446 dimerization interface [polypeptide binding]; other site 661367005447 active site 661367005448 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 661367005449 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367005450 phosphoenolpyruvate synthase; Validated; Region: PRK06464 661367005451 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 661367005452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 661367005453 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 661367005454 adenylosuccinate lyase; Provisional; Region: PRK09285 661367005455 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 661367005456 tetramer interface [polypeptide binding]; other site 661367005457 active site 661367005458 L-aspartate oxidase; Provisional; Region: PRK09077 661367005459 L-aspartate oxidase; Provisional; Region: PRK06175 661367005460 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367005461 quinolinate synthetase; Provisional; Region: PRK09375 661367005462 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 661367005463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367005464 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367005465 muropeptide transporter; Validated; Region: ampG; cl17669 661367005466 muropeptide transporter; Reviewed; Region: ampG; PRK11902 661367005467 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 661367005468 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 661367005469 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 661367005470 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 661367005471 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 661367005472 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 661367005473 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 661367005474 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 661367005475 Ligand Binding Site [chemical binding]; other site 661367005476 TilS substrate binding domain; Region: TilS; pfam09179 661367005477 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 661367005478 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 661367005479 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 661367005480 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 661367005481 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 661367005482 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 661367005483 Biotin operon repressor [Transcription]; Region: BirA; COG1654 661367005484 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 661367005485 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 661367005486 carbon storage regulator; Provisional; Region: PRK01712 661367005487 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 661367005488 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 661367005489 Mg++ binding site [ion binding]; other site 661367005490 putative catalytic motif [active] 661367005491 putative substrate binding site [chemical binding]; other site 661367005492 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367005493 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 661367005494 putative NAD(P) binding site [chemical binding]; other site 661367005495 active site 661367005496 putative substrate binding site [chemical binding]; other site 661367005497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367005498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 661367005499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367005500 S-adenosylmethionine binding site [chemical binding]; other site 661367005501 POT family; Region: PTR2; cl17359 661367005502 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 661367005503 lipoyl synthase; Provisional; Region: PRK05481 661367005504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367005505 FeS/SAM binding site; other site 661367005506 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 661367005507 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367005508 FOG: CBS domain [General function prediction only]; Region: COG0517 661367005509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 661367005510 BON domain; Region: BON; pfam04972 661367005511 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367005512 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 661367005513 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 661367005514 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367005515 HSP70 interaction site [polypeptide binding]; other site 661367005516 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 661367005517 substrate binding site [polypeptide binding]; other site 661367005518 dimer interface [polypeptide binding]; other site 661367005519 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 661367005520 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 661367005521 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 661367005522 Septum formation initiator; Region: DivIC; cl17659 661367005523 mevalonate kinase; Region: mevalon_kin; TIGR00549 661367005524 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 661367005525 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 661367005526 diphosphomevalonate decarboxylase; Region: PLN02407 661367005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367005528 binding surface 661367005529 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 661367005530 TPR motif; other site 661367005531 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 661367005532 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367005533 ligand binding site [chemical binding]; other site 661367005534 Protein of unknown function (DUF330); Region: DUF330; cl01135 661367005535 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 661367005536 mce related protein; Region: MCE; pfam02470 661367005537 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 661367005538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367005539 Walker A/P-loop; other site 661367005540 ATP binding site [chemical binding]; other site 661367005541 Q-loop/lid; other site 661367005542 ABC transporter signature motif; other site 661367005543 Walker B; other site 661367005544 D-loop; other site 661367005545 H-loop/switch region; other site 661367005546 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 661367005547 Permease; Region: Permease; pfam02405 661367005548 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 661367005549 homodimer interface [polypeptide binding]; other site 661367005550 catalytic residues [active] 661367005551 NAD binding site [chemical binding]; other site 661367005552 substrate binding pocket [chemical binding]; other site 661367005553 flexible flap; other site 661367005554 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 661367005555 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 661367005556 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 661367005557 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 661367005558 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 661367005559 Cupin domain; Region: Cupin_2; pfam07883 661367005560 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 661367005561 F-box-like; Region: F-box-like; cl02535 661367005562 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 661367005563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367005564 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 661367005565 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 661367005566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367005567 S-adenosylmethionine binding site [chemical binding]; other site 661367005568 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 661367005569 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 661367005570 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 661367005571 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005572 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367005573 Di-iron ligands [ion binding]; other site 661367005574 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 661367005575 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 661367005576 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 661367005577 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 661367005578 classical (c) SDRs; Region: SDR_c; cd05233 661367005579 NAD(P) binding site [chemical binding]; other site 661367005580 active site 661367005581 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 661367005582 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 661367005583 Outer membrane efflux protein; Region: OEP; pfam02321 661367005584 Outer membrane efflux protein; Region: OEP; pfam02321 661367005585 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367005586 hypothetical protein; Region: PHA00727 661367005587 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367005588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367005589 Q-loop/lid; other site 661367005590 ABC transporter signature motif; other site 661367005591 Walker B; other site 661367005592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367005594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 661367005595 dimerization interface [polypeptide binding]; other site 661367005596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 661367005597 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 661367005598 Nitrogen regulatory protein P-II; Region: P-II; cl00412 661367005599 Transcriptional regulators [Transcription]; Region: MarR; COG1846 661367005600 MarR family; Region: MarR_2; pfam12802 661367005601 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 661367005602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367005603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005604 ligand binding site [chemical binding]; other site 661367005605 CAAX protease self-immunity; Region: Abi; pfam02517 661367005606 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 661367005607 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 661367005608 FMN binding site [chemical binding]; other site 661367005609 active site 661367005610 substrate binding site [chemical binding]; other site 661367005611 catalytic residue [active] 661367005612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367005613 dimerization interface [polypeptide binding]; other site 661367005614 putative DNA binding site [nucleotide binding]; other site 661367005615 putative Zn2+ binding site [ion binding]; other site 661367005616 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367005617 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 661367005618 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367005619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367005620 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 661367005621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367005622 FtsX-like permease family; Region: FtsX; pfam02687 661367005623 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 661367005624 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 661367005625 Walker A/P-loop; other site 661367005626 ATP binding site [chemical binding]; other site 661367005627 Q-loop/lid; other site 661367005628 ABC transporter signature motif; other site 661367005629 Walker B; other site 661367005630 D-loop; other site 661367005631 H-loop/switch region; other site 661367005632 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 661367005633 Double zinc ribbon; Region: DZR; pfam12773 661367005634 TM2 domain; Region: TM2; pfam05154 661367005635 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 661367005636 active site 661367005637 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 661367005638 putative FMN binding site [chemical binding]; other site 661367005639 NADPH bind site [chemical binding]; other site 661367005640 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367005641 DNA-binding site [nucleotide binding]; DNA binding site 661367005642 RNA-binding motif; other site 661367005643 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 661367005644 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 661367005645 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 661367005646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 661367005647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367005648 catalytic residue [active] 661367005649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367005650 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367005651 Substrate binding site [chemical binding]; other site 661367005652 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367005653 Leucine-rich repeats; other site 661367005654 Substrate binding site [chemical binding]; other site 661367005655 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 661367005656 Predicted membrane protein [Function unknown]; Region: COG1971 661367005657 Domain of unknown function DUF; Region: DUF204; pfam02659 661367005658 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367005659 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367005660 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 661367005661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005662 TIGR01777 family protein; Region: yfcH 661367005663 NAD(P) binding site [chemical binding]; other site 661367005664 active site 661367005665 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 661367005666 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 661367005667 putative active site [active] 661367005668 putative dimer interface [polypeptide binding]; other site 661367005669 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 661367005670 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367005671 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 661367005672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367005673 inhibitor-cofactor binding pocket; inhibition site 661367005674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367005675 catalytic residue [active] 661367005676 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367005677 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 661367005678 DNA binding residues [nucleotide binding] 661367005679 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 661367005680 dimer interface [polypeptide binding]; other site 661367005681 mercury binding site [ion binding]; other site 661367005682 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 661367005683 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367005685 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367005686 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367005687 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367005688 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 661367005689 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 661367005690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 661367005691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367005692 Coenzyme A binding pocket [chemical binding]; other site 661367005693 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 661367005694 Cache domain; Region: Cache_1; pfam02743 661367005695 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 661367005696 cyclase homology domain; Region: CHD; cd07302 661367005697 nucleotidyl binding site; other site 661367005698 metal binding site [ion binding]; metal-binding site 661367005699 dimer interface [polypeptide binding]; other site 661367005700 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 661367005701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 661367005702 Beta-Casp domain; Region: Beta-Casp; smart01027 661367005703 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 661367005704 thymidine phosphorylase; Provisional; Region: PRK04350 661367005705 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 661367005706 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 661367005707 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 661367005708 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 661367005709 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 661367005710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367005711 active site 661367005712 Tubulin-tyrosine ligase family; Region: TTL; pfam03133 661367005713 MltA specific insert domain; Region: MltA; cl08398 661367005714 3D domain; Region: 3D; pfam06725 661367005715 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 661367005716 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 661367005717 catalytic site [active] 661367005718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 661367005719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367005720 Coenzyme A binding pocket [chemical binding]; other site 661367005721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367005722 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 661367005723 Coenzyme A binding pocket [chemical binding]; other site 661367005724 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 661367005725 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 661367005726 Chromate transporter; Region: Chromate_transp; pfam02417 661367005727 Dot/Icm substrate protein; Region: SidE; pfam12252 661367005728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367005730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367005731 dimerization interface [polypeptide binding]; other site 661367005732 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367005733 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 661367005734 substrate binding pocket [chemical binding]; other site 661367005735 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 661367005736 active site 661367005737 iron coordination sites [ion binding]; other site 661367005738 hypothetical protein; Provisional; Region: PRK07190 661367005739 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367005740 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367005741 hypothetical protein; Provisional; Region: PRK07206 661367005742 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 661367005743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005744 PAS domain; Region: PAS_9; pfam13426 661367005745 putative active site [active] 661367005746 heme pocket [chemical binding]; other site 661367005747 Response regulator receiver domain; Region: Response_reg; pfam00072 661367005748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367005749 active site 661367005750 phosphorylation site [posttranslational modification] 661367005751 intermolecular recognition site; other site 661367005752 dimerization interface [polypeptide binding]; other site 661367005753 PAS fold; Region: PAS_4; pfam08448 661367005754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 661367005755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367005756 DNA binding residues [nucleotide binding] 661367005757 dimerization interface [polypeptide binding]; other site 661367005758 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367005759 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367005760 active site 661367005761 ATP binding site [chemical binding]; other site 661367005762 substrate binding site [chemical binding]; other site 661367005763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005764 substrate binding site [chemical binding]; other site 661367005765 activation loop (A-loop); other site 661367005766 activation loop (A-loop); other site 661367005767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005768 active site 661367005769 motif I; other site 661367005770 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 661367005771 motif II; other site 661367005772 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 661367005773 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 661367005774 active site 661367005775 catalytic triad [active] 661367005776 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367005777 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367005778 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 661367005779 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 661367005780 acyl-activating enzyme (AAE) consensus motif; other site 661367005781 AMP binding site [chemical binding]; other site 661367005782 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367005783 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367005784 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 661367005785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005786 NADH(P)-binding; Region: NAD_binding_10; pfam13460 661367005787 NAD(P) binding site [chemical binding]; other site 661367005788 active site 661367005789 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 661367005790 Amidohydrolase; Region: Amidohydro_2; pfam04909 661367005791 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 661367005792 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 661367005793 probable polyamine oxidase; Region: PLN02268 661367005794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 661367005795 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 661367005796 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 661367005797 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 661367005798 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 661367005799 PYR/PP interface [polypeptide binding]; other site 661367005800 dimer interface [polypeptide binding]; other site 661367005801 TPP binding site [chemical binding]; other site 661367005802 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 661367005803 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 661367005804 TPP-binding site; other site 661367005805 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 661367005806 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 661367005807 substrate binding site [chemical binding]; other site 661367005808 ATP binding site [chemical binding]; other site 661367005809 KduI/IolB family; Region: KduI; pfam04962 661367005810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 661367005811 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367005812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 661367005813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367005815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005816 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 661367005817 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 661367005818 active site 661367005819 FMN binding site [chemical binding]; other site 661367005820 substrate binding site [chemical binding]; other site 661367005821 3Fe-4S cluster binding site [ion binding]; other site 661367005822 enterobactin exporter EntS; Provisional; Region: PRK10489 661367005823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005824 putative substrate translocation pore; other site 661367005825 putative metal dependent hydrolase; Provisional; Region: PRK11598 661367005826 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 661367005827 Sulfatase; Region: Sulfatase; pfam00884 661367005828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367005829 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 661367005830 active site 661367005831 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 661367005832 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 661367005833 metal binding triad [ion binding]; metal-binding site 661367005834 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 661367005835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367005836 Zn2+ binding site [ion binding]; other site 661367005837 Mg2+ binding site [ion binding]; other site 661367005838 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 661367005839 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 661367005840 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 661367005841 Switch II region; other site 661367005842 G4 box; other site 661367005843 G5 box; other site 661367005844 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 661367005845 nucleoside/Zn binding site; other site 661367005846 dimer interface [polypeptide binding]; other site 661367005847 catalytic motif [active] 661367005848 GMP synthase; Reviewed; Region: guaA; PRK00074 661367005849 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 661367005850 AMP/PPi binding site [chemical binding]; other site 661367005851 candidate oxyanion hole; other site 661367005852 catalytic triad [active] 661367005853 potential glutamine specificity residues [chemical binding]; other site 661367005854 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 661367005855 ATP Binding subdomain [chemical binding]; other site 661367005856 Ligand Binding sites [chemical binding]; other site 661367005857 Dimerization subdomain; other site 661367005858 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 661367005859 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 661367005860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 661367005861 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 661367005862 active site 661367005863 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 661367005864 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 661367005865 Switch I; other site 661367005866 Switch II; other site 661367005867 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 661367005868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367005870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367005871 dimerization interface [polypeptide binding]; other site 661367005872 FecR protein; Region: FecR; pfam04773 661367005873 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 661367005874 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 661367005875 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 661367005876 active site 661367005877 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 661367005878 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 661367005879 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 661367005880 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 661367005881 Walker A/P-loop; other site 661367005882 ATP binding site [chemical binding]; other site 661367005883 Q-loop/lid; other site 661367005884 ABC transporter signature motif; other site 661367005885 Walker B; other site 661367005886 D-loop; other site 661367005887 H-loop/switch region; other site 661367005888 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 661367005889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005890 dimer interface [polypeptide binding]; other site 661367005891 conserved gate region; other site 661367005892 ABC-ATPase subunit interface; other site 661367005893 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 661367005894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005895 dimer interface [polypeptide binding]; other site 661367005896 conserved gate region; other site 661367005897 putative PBP binding loops; other site 661367005898 ABC-ATPase subunit interface; other site 661367005899 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 661367005900 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 661367005901 NAD(P) binding site [chemical binding]; other site 661367005902 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 661367005903 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 661367005904 Cl- selectivity filter; other site 661367005905 Cl- binding residues [ion binding]; other site 661367005906 pore gating glutamate residue; other site 661367005907 dimer interface [polypeptide binding]; other site 661367005908 H+/Cl- coupling transport residue; other site 661367005909 anthranilate synthase; Provisional; Region: PRK13566 661367005910 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 661367005911 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 661367005912 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 661367005913 glutamine binding [chemical binding]; other site 661367005914 catalytic triad [active] 661367005915 D123; Region: D123; pfam07065 661367005916 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 661367005917 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 661367005918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005919 motif II; other site 661367005920 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367005921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367005922 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367005923 Uncharacterized conserved protein [Function unknown]; Region: COG3268 661367005924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005925 NAD(P) binding site [chemical binding]; other site 661367005926 Lyase; Region: Lyase_1; pfam00206 661367005927 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 661367005928 active sites [active] 661367005929 tetramer interface [polypeptide binding]; other site 661367005930 argininosuccinate synthase; Provisional; Region: PRK13820 661367005931 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 661367005932 ANP binding site [chemical binding]; other site 661367005933 Substrate Binding Site II [chemical binding]; other site 661367005934 Substrate Binding Site I [chemical binding]; other site 661367005935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 661367005936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367005937 Walker A/P-loop; other site 661367005938 ATP binding site [chemical binding]; other site 661367005939 Q-loop/lid; other site 661367005940 ABC transporter signature motif; other site 661367005941 Walker B; other site 661367005942 D-loop; other site 661367005943 H-loop/switch region; other site 661367005944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005945 dimer interface [polypeptide binding]; other site 661367005946 conserved gate region; other site 661367005947 putative PBP binding loops; other site 661367005948 ABC-ATPase subunit interface; other site 661367005949 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367005950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367005951 substrate binding pocket [chemical binding]; other site 661367005952 membrane-bound complex binding site; other site 661367005953 hinge residues; other site 661367005954 arginine repressor; Region: argR_whole; TIGR01529 661367005955 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 661367005956 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 661367005957 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 661367005958 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 661367005959 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367005960 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 661367005961 Walker A/P-loop; other site 661367005962 ATP binding site [chemical binding]; other site 661367005963 Q-loop/lid; other site 661367005964 ABC transporter signature motif; other site 661367005965 Walker B; other site 661367005966 D-loop; other site 661367005967 H-loop/switch region; other site 661367005968 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367005969 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005970 ligand binding site [chemical binding]; other site 661367005971 flexible hinge region; other site 661367005972 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005973 ligand binding site [chemical binding]; other site 661367005974 flexible hinge region; other site 661367005975 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 661367005976 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 661367005977 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 661367005978 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 661367005979 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 661367005980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367005981 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367005982 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367005983 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005984 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367005985 Di-iron ligands [ion binding]; other site 661367005986 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005987 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 661367005988 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 661367005989 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 661367005990 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 661367005991 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 661367005992 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 661367005993 GatB domain; Region: GatB_Yqey; smart00845 661367005994 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367005995 nucleophile elbow; other site 661367005996 Patatin phospholipase; Region: DUF3734; pfam12536 661367005997 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 661367005998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367005999 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 661367006000 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 661367006001 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 661367006002 active site 661367006003 dimerization interface [polypeptide binding]; other site 661367006004 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 661367006005 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 661367006006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367006007 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 661367006008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367006009 catalytic residue [active] 661367006010 trimerization site [polypeptide binding]; other site 661367006011 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 661367006012 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 661367006013 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 661367006014 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 661367006015 tandem repeat interface [polypeptide binding]; other site 661367006016 oligomer interface [polypeptide binding]; other site 661367006017 active site residues [active] 661367006018 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 661367006019 Clp amino terminal domain; Region: Clp_N; pfam02861 661367006020 Clp amino terminal domain; Region: Clp_N; pfam02861 661367006021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006022 Walker A motif; other site 661367006023 ATP binding site [chemical binding]; other site 661367006024 Walker B motif; other site 661367006025 arginine finger; other site 661367006026 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 661367006027 primary dimer interface [polypeptide binding]; other site 661367006028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006029 Walker A motif; other site 661367006030 ATP binding site [chemical binding]; other site 661367006031 Walker B motif; other site 661367006032 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 661367006033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367006034 active site 661367006035 motif I; other site 661367006036 motif II; other site 661367006037 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 661367006038 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367006039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006041 TIGR02099 family protein; Region: TIGR02099 661367006042 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 661367006043 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367006044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006045 active site 661367006046 phosphorylation site [posttranslational modification] 661367006047 intermolecular recognition site; other site 661367006048 dimerization interface [polypeptide binding]; other site 661367006049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006050 Walker A motif; other site 661367006051 ATP binding site [chemical binding]; other site 661367006052 Walker B motif; other site 661367006053 arginine finger; other site 661367006054 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 661367006055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367006056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367006057 putative active site [active] 661367006058 heme pocket [chemical binding]; other site 661367006059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006060 dimer interface [polypeptide binding]; other site 661367006061 phosphorylation site [posttranslational modification] 661367006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006063 ATP binding site [chemical binding]; other site 661367006064 Mg2+ binding site [ion binding]; other site 661367006065 G-X-G motif; other site 661367006066 recombination factor protein RarA; Reviewed; Region: PRK13342 661367006067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006068 Walker A motif; other site 661367006069 ATP binding site [chemical binding]; other site 661367006070 Walker B motif; other site 661367006071 arginine finger; other site 661367006072 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 661367006073 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 661367006074 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 661367006075 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 661367006076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 661367006077 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 661367006078 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 661367006079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367006080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367006081 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 661367006082 Src homology 2 (SH2) domain; Region: SH2; cd00173 661367006083 phosphotyrosine binding pocket [polypeptide binding]; other site 661367006084 hydrophobic binding pocket [polypeptide binding]; other site 661367006085 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 661367006086 rRNA binding site [nucleotide binding]; other site 661367006087 predicted 30S ribosome binding site; other site 661367006088 Rab GTPase; Provisional; Region: PLN03110 661367006089 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 661367006090 G1 box; other site 661367006091 GTP/Mg2+ binding site [chemical binding]; other site 661367006092 G2 box; other site 661367006093 Switch I region; other site 661367006094 G3 box; other site 661367006095 Switch II region; other site 661367006096 G4 box; other site 661367006097 G5 box; other site 661367006098 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 661367006099 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367006100 dimer interface [polypeptide binding]; other site 661367006101 active site 661367006102 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 661367006103 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 661367006104 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 661367006105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367006106 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 661367006107 substrate binding site [chemical binding]; other site 661367006108 oxyanion hole (OAH) forming residues; other site 661367006109 trimer interface [polypeptide binding]; other site 661367006110 aldehyde dehydrogenase family 7 member; Region: PLN02315 661367006111 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 661367006112 tetrameric interface [polypeptide binding]; other site 661367006113 NAD binding site [chemical binding]; other site 661367006114 catalytic residues [active] 661367006115 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 661367006116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006117 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 661367006118 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 661367006119 putative active site [active] 661367006120 catalytic triad [active] 661367006121 putative dimer interface [polypeptide binding]; other site 661367006122 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 661367006123 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 661367006124 HIGH motif; other site 661367006125 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367006126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367006127 active site 661367006128 KMSKS motif; other site 661367006129 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 661367006130 tRNA binding surface [nucleotide binding]; other site 661367006131 Lipopolysaccharide-assembly; Region: LptE; cl01125 661367006132 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 661367006133 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 661367006134 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 661367006135 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 661367006136 active site 661367006137 (T/H)XGH motif; other site 661367006138 Colicin V production protein; Region: Colicin_V; pfam02674 661367006139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 661367006140 Sporulation related domain; Region: SPOR; pfam05036 661367006141 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 661367006142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006143 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 661367006144 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 661367006145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367006146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006147 putative substrate translocation pore; other site 661367006148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006149 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 661367006150 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 661367006151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367006152 FeS/SAM binding site; other site 661367006153 TRAM domain; Region: TRAM; pfam01938 661367006154 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 661367006155 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367006156 RNA binding surface [nucleotide binding]; other site 661367006157 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 661367006158 active site 661367006159 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 661367006160 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 661367006161 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 661367006162 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 661367006163 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367006164 protein binding site [polypeptide binding]; other site 661367006165 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367006166 Cytochrome c; Region: Cytochrom_C; cl11414 661367006167 Smr domain; Region: Smr; cl02619 661367006168 Ataxin-2 C-terminal region; Region: PAM2; pfam07145 661367006169 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 661367006170 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 661367006171 nudix motif; other site 661367006172 Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015 661367006173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367006174 S-adenosylmethionine binding site [chemical binding]; other site 661367006175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367006176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367006177 catalytic residue [active] 661367006178 Chitin binding domain; Region: Chitin_bind_3; pfam03067 661367006179 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 661367006180 propionate/acetate kinase; Provisional; Region: PRK12379 661367006181 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 661367006182 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 661367006183 dimer interaction site [polypeptide binding]; other site 661367006184 substrate-binding tunnel; other site 661367006185 active site 661367006186 catalytic site [active] 661367006187 substrate binding site [chemical binding]; other site 661367006188 phosphate acetyltransferase; Provisional; Region: PRK11890 661367006189 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 661367006190 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367006191 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367006192 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367006193 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367006194 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 661367006195 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 661367006196 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 661367006197 RF-1 domain; Region: RF-1; pfam00472 661367006198 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367006199 HSP70 interaction site [polypeptide binding]; other site 661367006200 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 661367006201 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 661367006202 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 661367006203 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 661367006204 siderophore binding site; other site 661367006205 ParB-like nuclease domain; Region: ParBc; pfam02195 661367006206 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 661367006207 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 661367006208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 661367006209 dimer interface [polypeptide binding]; other site 661367006210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367006211 catalytic residue [active] 661367006212 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 661367006213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367006214 dimer interface [polypeptide binding]; other site 661367006215 ABC-ATPase subunit interface; other site 661367006216 putative PBP binding regions; other site 661367006217 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 661367006218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367006219 ABC-ATPase subunit interface; other site 661367006220 dimer interface [polypeptide binding]; other site 661367006221 putative PBP binding regions; other site 661367006222 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 661367006223 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 661367006224 Walker A/P-loop; other site 661367006225 ATP binding site [chemical binding]; other site 661367006226 Q-loop/lid; other site 661367006227 ABC transporter signature motif; other site 661367006228 Walker B; other site 661367006229 D-loop; other site 661367006230 H-loop/switch region; other site 661367006231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006233 putative substrate translocation pore; other site 661367006234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006235 TMPIT-like protein; Region: TMPIT; pfam07851 661367006236 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 661367006237 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367006238 Di-iron ligands [ion binding]; other site 661367006239 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 661367006240 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 661367006241 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367006242 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367006243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006244 ligand binding site [chemical binding]; other site 661367006245 potassium uptake protein; Region: kup; TIGR00794 661367006246 K+ potassium transporter; Region: K_trans; pfam02705 661367006247 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367006248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006249 putative substrate translocation pore; other site 661367006250 EamA-like transporter family; Region: EamA; cl17759 661367006251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367006252 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367006253 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 661367006254 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367006255 active site 661367006256 nucleophile elbow; other site 661367006257 Patatin phospholipase; Region: DUF3734; pfam12536 661367006258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 661367006259 PAS domain; Region: PAS_9; pfam13426 661367006260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367006261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006262 dimer interface [polypeptide binding]; other site 661367006263 phosphorylation site [posttranslational modification] 661367006264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006265 ATP binding site [chemical binding]; other site 661367006266 Mg2+ binding site [ion binding]; other site 661367006267 G-X-G motif; other site 661367006268 Response regulator receiver domain; Region: Response_reg; pfam00072 661367006269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006270 active site 661367006271 phosphorylation site [posttranslational modification] 661367006272 intermolecular recognition site; other site 661367006273 dimerization interface [polypeptide binding]; other site 661367006274 acetylornithine deacetylase; Provisional; Region: PRK07522 661367006275 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 661367006276 metal binding site [ion binding]; metal-binding site 661367006277 putative dimer interface [polypeptide binding]; other site 661367006278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006279 D-galactonate transporter; Region: 2A0114; TIGR00893 661367006280 putative substrate translocation pore; other site 661367006281 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 661367006282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367006283 putative DNA binding site [nucleotide binding]; other site 661367006284 putative Zn2+ binding site [ion binding]; other site 661367006285 AsnC family; Region: AsnC_trans_reg; pfam01037 661367006286 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367006287 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367006288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367006289 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367006290 Predicted membrane protein [Function unknown]; Region: COG1289 661367006291 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367006292 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 661367006293 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 661367006294 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 661367006295 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 661367006296 G1 box; other site 661367006297 GTP/Mg2+ binding site [chemical binding]; other site 661367006298 G2 box; other site 661367006299 Switch I region; other site 661367006300 Switch II region; other site 661367006301 G4 box; other site 661367006302 G5 box; other site 661367006303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367006304 Ligand Binding Site [chemical binding]; other site 661367006305 Zeta toxin; Region: Zeta_toxin; pfam06414 661367006306 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367006307 Lipase (class 2); Region: Lipase_2; pfam01674 661367006308 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 661367006309 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 661367006310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367006311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367006312 active site 661367006313 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367006314 active site 661367006315 ATP binding site [chemical binding]; other site 661367006316 substrate binding site [chemical binding]; other site 661367006317 activation loop (A-loop); other site 661367006318 High-affinity nickel-transport protein; Region: NicO; cl00964 661367006319 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 661367006320 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 661367006321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 661367006322 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 661367006323 Acylphosphatase; Region: Acylphosphatase; pfam00708 661367006324 HypF finger; Region: zf-HYPF; pfam07503 661367006325 HypF finger; Region: zf-HYPF; pfam07503 661367006326 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 661367006327 HupF/HypC family; Region: HupF_HypC; pfam01455 661367006328 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 661367006329 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 661367006330 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 661367006331 dimerization interface [polypeptide binding]; other site 661367006332 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 661367006333 ATP binding site [chemical binding]; other site 661367006334 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 661367006335 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 661367006336 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 661367006337 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 661367006338 FAD binding pocket [chemical binding]; other site 661367006339 FAD binding motif [chemical binding]; other site 661367006340 phosphate binding motif [ion binding]; other site 661367006341 beta-alpha-beta structure motif; other site 661367006342 NAD binding pocket [chemical binding]; other site 661367006343 Iron coordination center [ion binding]; other site 661367006344 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 661367006345 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 661367006346 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 661367006347 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 661367006348 nickel binding site [ion binding]; other site 661367006349 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 661367006350 Fe-S cluster binding site [ion binding]; other site 661367006351 active site 661367006352 LicD family; Region: LicD; cl01378 661367006353 Zeta toxin; Region: Zeta_toxin; pfam06414 661367006354 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 661367006355 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 661367006356 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 661367006357 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367006358 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 661367006359 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367006360 Sulfate transporter family; Region: Sulfate_transp; pfam00916 661367006361 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367006362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006363 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367006364 ligand binding site [chemical binding]; other site 661367006365 flexible hinge region; other site 661367006366 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 661367006367 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 661367006368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367006369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367006370 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 661367006371 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 661367006372 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 661367006373 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 661367006374 Ligand Binding Site [chemical binding]; other site 661367006375 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 661367006376 GAF domain; Region: GAF_2; pfam13185 661367006377 GAF domain; Region: GAF_3; pfam13492 661367006378 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 661367006379 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 661367006380 ligand binding site [chemical binding]; other site 661367006381 homodimer interface [polypeptide binding]; other site 661367006382 NAD(P) binding site [chemical binding]; other site 661367006383 trimer interface B [polypeptide binding]; other site 661367006384 trimer interface A [polypeptide binding]; other site 661367006385 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 661367006386 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 661367006387 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 661367006388 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006389 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367006390 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 661367006391 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 661367006392 G1 box; other site 661367006393 putative GEF interaction site [polypeptide binding]; other site 661367006394 GTP/Mg2+ binding site [chemical binding]; other site 661367006395 Switch I region; other site 661367006396 G2 box; other site 661367006397 G3 box; other site 661367006398 Switch II region; other site 661367006399 G4 box; other site 661367006400 G5 box; other site 661367006401 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 661367006402 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 661367006403 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 661367006404 S-formylglutathione hydrolase; Region: PLN02442 661367006405 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 661367006406 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 661367006407 substrate binding site [chemical binding]; other site 661367006408 catalytic Zn binding site [ion binding]; other site 661367006409 NAD binding site [chemical binding]; other site 661367006410 structural Zn binding site [ion binding]; other site 661367006411 dimer interface [polypeptide binding]; other site 661367006412 putative hydrolase; Provisional; Region: PRK10985 661367006413 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 661367006414 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 661367006415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 661367006416 Beta-lactamase; Region: Beta-lactamase; pfam00144 661367006417 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 661367006418 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 661367006419 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 661367006420 NAD(P) binding site [chemical binding]; other site 661367006421 catalytic residues [active] 661367006422 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 661367006423 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 661367006424 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 661367006425 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 661367006426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367006427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006428 dimer interface [polypeptide binding]; other site 661367006429 phosphorylation site [posttranslational modification] 661367006430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006431 ATP binding site [chemical binding]; other site 661367006432 Mg2+ binding site [ion binding]; other site 661367006433 G-X-G motif; other site 661367006434 Response regulator receiver domain; Region: Response_reg; pfam00072 661367006435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006436 active site 661367006437 phosphorylation site [posttranslational modification] 661367006438 intermolecular recognition site; other site 661367006439 dimerization interface [polypeptide binding]; other site 661367006440 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367006441 putative binding surface; other site 661367006442 active site 661367006443 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 661367006444 Uncharacterized conserved protein [Function unknown]; Region: COG0397 661367006445 hypothetical protein; Validated; Region: PRK00029 661367006446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367006447 Coenzyme A binding pocket [chemical binding]; other site 661367006448 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 661367006449 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 661367006450 E-class dimer interface [polypeptide binding]; other site 661367006451 P-class dimer interface [polypeptide binding]; other site 661367006452 active site 661367006453 Cu2+ binding site [ion binding]; other site 661367006454 Zn2+ binding site [ion binding]; other site 661367006455 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 661367006456 active site 661367006457 catalytic residues [active] 661367006458 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 661367006459 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 661367006460 homotetramer interface [polypeptide binding]; other site 661367006461 ligand binding site [chemical binding]; other site 661367006462 catalytic site [active] 661367006463 NAD binding site [chemical binding]; other site 661367006464 S-adenosylmethionine synthetase; Validated; Region: PRK05250 661367006465 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 661367006466 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 661367006467 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 661367006468 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 661367006469 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 661367006470 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 661367006471 catalytic site [active] 661367006472 subunit interface [polypeptide binding]; other site 661367006473 chaperone protein DnaJ; Provisional; Region: PRK10767 661367006474 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367006475 HSP70 interaction site [polypeptide binding]; other site 661367006476 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 661367006477 Zn binding sites [ion binding]; other site 661367006478 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 661367006479 dimer interface [polypeptide binding]; other site 661367006480 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 661367006481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 661367006482 nucleotide binding site [chemical binding]; other site 661367006483 GrpE; Region: GrpE; pfam01025 661367006484 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 661367006485 dimer interface [polypeptide binding]; other site 661367006486 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 661367006487 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 661367006488 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 661367006489 substrate binding site [chemical binding]; other site 661367006490 active site 661367006491 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 661367006492 active site 661367006493 catalytic triad [active] 661367006494 oxyanion hole [active] 661367006495 Dihydroneopterin aldolase; Region: FolB; smart00905 661367006496 active site 661367006497 Sporulation related domain; Region: SPOR; pfam05036 661367006498 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 661367006499 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 661367006500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367006501 active site 661367006502 HIGH motif; other site 661367006503 nucleotide binding site [chemical binding]; other site 661367006504 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 661367006505 KMSK motif region; other site 661367006506 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 661367006507 tRNA binding surface [nucleotide binding]; other site 661367006508 anticodon binding site; other site 661367006509 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 661367006510 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 661367006511 generic binding surface II; other site 661367006512 ssDNA binding site; other site 661367006513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367006514 ATP binding site [chemical binding]; other site 661367006515 putative Mg++ binding site [ion binding]; other site 661367006516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367006517 nucleotide binding region [chemical binding]; other site 661367006518 ATP-binding site [chemical binding]; other site 661367006519 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 661367006520 Cation efflux family; Region: Cation_efflux; pfam01545 661367006521 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 661367006522 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 661367006523 active site 661367006524 dimer interface [polypeptide binding]; other site 661367006525 enolase; Provisional; Region: eno; PRK00077 661367006526 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 661367006527 dimer interface [polypeptide binding]; other site 661367006528 metal binding site [ion binding]; metal-binding site 661367006529 substrate binding pocket [chemical binding]; other site 661367006530 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 661367006531 nucleoside/Zn binding site; other site 661367006532 dimer interface [polypeptide binding]; other site 661367006533 catalytic motif [active] 661367006534 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367006535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367006536 putative DNA binding site [nucleotide binding]; other site 661367006537 dimerization interface [polypeptide binding]; other site 661367006538 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 661367006539 putative Zn2+ binding site [ion binding]; other site 661367006540 AsnC family; Region: AsnC_trans_reg; pfam01037 661367006541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 661367006542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367006543 Coenzyme A binding pocket [chemical binding]; other site 661367006544 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367006545 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 661367006546 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 661367006547 putative acyl-acceptor binding pocket; other site 661367006548 probable DNA repair protein; Region: TIGR03623 661367006549 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 661367006550 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 661367006551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367006552 ligand binding site [chemical binding]; other site 661367006553 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 661367006554 aromatic amino acid transport protein; Region: araaP; TIGR00837 661367006555 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 661367006556 aromatic amino acid transport protein; Region: araaP; TIGR00837 661367006557 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 661367006558 catalytic nucleophile [active] 661367006559 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 661367006560 proposed catalytic triad [active] 661367006561 active site nucleophile [active] 661367006562 cyanophycin synthetase; Provisional; Region: PRK14016 661367006563 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367006564 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367006565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006567 PRC-barrel domain; Region: PRC; pfam05239 661367006568 CsbD-like; Region: CsbD; cl17424 661367006569 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 661367006570 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 661367006571 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367006572 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 661367006573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 661367006574 catalytic residues [active] 661367006575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367006576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006577 ligand binding site [chemical binding]; other site 661367006578 flexible hinge region; other site 661367006579 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 661367006580 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 661367006581 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 661367006582 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 661367006583 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 661367006584 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 661367006585 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 661367006586 Coenzyme A transferase; Region: CoA_trans; cl17247 661367006587 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 661367006588 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367006589 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367006590 putative dimer interface [polypeptide binding]; other site 661367006591 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367006592 active site clefts [active] 661367006593 zinc binding site [ion binding]; other site 661367006594 dimer interface [polypeptide binding]; other site 661367006595 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 661367006596 active site 661367006597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006598 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367006599 putative substrate translocation pore; other site 661367006600 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 661367006601 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 661367006602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006603 putative substrate translocation pore; other site 661367006604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006606 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 661367006607 putative substrate translocation pore; other site 661367006608 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 661367006609 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367006610 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 661367006611 putative NAD(P) binding site [chemical binding]; other site 661367006612 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 661367006613 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 661367006614 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 661367006615 dimerization interface [polypeptide binding]; other site 661367006616 DPS ferroxidase diiron center [ion binding]; other site 661367006617 ion pore; other site 661367006618 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 661367006619 putative catalytic site [active] 661367006620 putative phosphate binding site [ion binding]; other site 661367006621 active site 661367006622 metal binding site A [ion binding]; metal-binding site 661367006623 DNA binding site [nucleotide binding] 661367006624 putative AP binding site [nucleotide binding]; other site 661367006625 putative metal binding site B [ion binding]; other site 661367006626 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 661367006627 putative active site [active] 661367006628 putative catalytic site [active] 661367006629 putative DNA binding site [nucleotide binding]; other site 661367006630 putative phosphate binding site [ion binding]; other site 661367006631 metal binding site A [ion binding]; metal-binding site 661367006632 putative AP binding site [nucleotide binding]; other site 661367006633 putative metal binding site B [ion binding]; other site 661367006634 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 661367006635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 661367006636 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 661367006637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006638 Walker A motif; other site 661367006639 ATP binding site [chemical binding]; other site 661367006640 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 661367006641 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 661367006642 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 661367006643 active site 661367006644 HslU subunit interaction site [polypeptide binding]; other site 661367006645 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 661367006646 phosphopentomutase; Provisional; Region: PRK05362 661367006647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006649 putative substrate translocation pore; other site 661367006650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006652 putative substrate translocation pore; other site 661367006653 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 661367006654 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 661367006655 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 661367006656 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367006657 NodB motif; other site 661367006658 putative active site [active] 661367006659 putative catalytic site [active] 661367006660 putative Zn binding site [ion binding]; other site 661367006661 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367006662 Type II transport protein GspH; Region: GspH; pfam12019 661367006663 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 661367006664 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 661367006665 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 661367006666 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 661367006667 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 661367006668 von Willebrand factor type A domain; Region: VWA_2; pfam13519 661367006669 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 661367006670 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 661367006671 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 661367006672 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 661367006673 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 661367006674 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 661367006675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367006676 dimer interface [polypeptide binding]; other site 661367006677 conserved gate region; other site 661367006678 putative PBP binding loops; other site 661367006679 ABC-ATPase subunit interface; other site 661367006680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367006681 putative PBP binding loops; other site 661367006682 dimer interface [polypeptide binding]; other site 661367006683 ABC-ATPase subunit interface; other site 661367006684 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 661367006685 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 661367006686 Walker A/P-loop; other site 661367006687 ATP binding site [chemical binding]; other site 661367006688 Q-loop/lid; other site 661367006689 ABC transporter signature motif; other site 661367006690 Walker B; other site 661367006691 D-loop; other site 661367006692 H-loop/switch region; other site 661367006693 TOBE domain; Region: TOBE_2; pfam08402 661367006694 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 661367006695 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 661367006696 Competence protein; Region: Competence; pfam03772 661367006697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 661367006698 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 661367006699 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 661367006700 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 661367006701 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 661367006702 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 661367006703 DNA binding site [nucleotide binding] 661367006704 active site 661367006705 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367006706 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367006707 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 661367006708 heme-binding site [chemical binding]; other site 661367006709 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 661367006710 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 661367006711 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 661367006712 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 661367006713 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367006714 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 661367006715 putative trimer interface [polypeptide binding]; other site 661367006716 putative CoA binding site [chemical binding]; other site 661367006717 GH3 auxin-responsive promoter; Region: GH3; pfam03321 661367006718 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 661367006719 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 661367006720 active site 661367006721 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 661367006722 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 661367006723 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 661367006724 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 661367006725 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 661367006726 active site 661367006727 acyl-CoA synthetase; Validated; Region: PRK05850 661367006728 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 661367006729 acyl-activating enzyme (AAE) consensus motif; other site 661367006730 active site 661367006731 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 661367006732 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 661367006733 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 661367006734 acyl-activating enzyme (AAE) consensus motif; other site 661367006735 acyl-activating enzyme (AAE) consensus motif; other site 661367006736 AMP binding site [chemical binding]; other site 661367006737 active site 661367006738 CoA binding site [chemical binding]; other site 661367006739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367006740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367006741 classical (c) SDRs; Region: SDR_c; cd05233 661367006742 NAD(P) binding site [chemical binding]; other site 661367006743 active site 661367006744 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 661367006745 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367006746 dimer interface [polypeptide binding]; other site 661367006747 active site 661367006748 CoA binding pocket [chemical binding]; other site 661367006749 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 661367006750 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367006751 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 661367006752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006753 putative substrate translocation pore; other site 661367006754 MAPEG family; Region: MAPEG; cl09190 661367006755 hypothetical protein; Validated; Region: PRK07198 661367006756 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 661367006757 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 661367006758 dimerization interface [polypeptide binding]; other site 661367006759 active site 661367006760 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 661367006761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367006762 active site 661367006763 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 661367006764 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 661367006765 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 661367006766 ParB-like nuclease domain; Region: ParBc; pfam02195 661367006767 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 661367006768 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367006769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367006770 active site 661367006771 metal binding site [ion binding]; metal-binding site 661367006772 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 661367006773 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367006774 active site 661367006775 catalytic triad [active] 661367006776 oxyanion hole [active] 661367006777 glutathione reductase; Validated; Region: PRK06116 661367006778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367006779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367006780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367006781 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367006782 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 661367006783 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 661367006784 trimer interface [polypeptide binding]; other site 661367006785 putative metal binding site [ion binding]; other site 661367006786 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 661367006787 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 661367006788 active site 661367006789 HIGH motif; other site 661367006790 dimer interface [polypeptide binding]; other site 661367006791 KMSKS motif; other site 661367006792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367006793 RNA binding surface [nucleotide binding]; other site 661367006794 putative peptidase; Provisional; Region: PRK11649 661367006795 Peptidase family M23; Region: Peptidase_M23; pfam01551 661367006796 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367006797 active site residue [active] 661367006798 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 661367006799 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 661367006800 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 661367006801 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 661367006802 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 661367006803 multifunctional aminopeptidase A; Provisional; Region: PRK00913 661367006804 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 661367006805 interface (dimer of trimers) [polypeptide binding]; other site 661367006806 Substrate-binding/catalytic site; other site 661367006807 Zn-binding sites [ion binding]; other site 661367006808 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 661367006809 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 661367006810 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 661367006811 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 661367006812 interface (dimer of trimers) [polypeptide binding]; other site 661367006813 Substrate-binding/catalytic site; other site 661367006814 Zn-binding sites [ion binding]; other site 661367006815 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 661367006816 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 661367006817 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 661367006818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367006819 TPR motif; other site 661367006820 binding surface 661367006821 putative transporter; Provisional; Region: PRK11660 661367006822 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 661367006823 Sulfate transporter family; Region: Sulfate_transp; pfam00916 661367006824 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367006825 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006826 Sel1-like repeats; Region: SEL1; smart00671 661367006827 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006828 Sel1-like repeats; Region: SEL1; smart00671 661367006829 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006830 Sel1-like repeats; Region: SEL1; smart00671 661367006831 Sel1-like repeats; Region: SEL1; smart00671 661367006832 Sel1-like repeats; Region: SEL1; smart00671 661367006833 Sel1-like repeats; Region: SEL1; smart00671 661367006834 Sel1-like repeats; Region: SEL1; smart00671 661367006835 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367006836 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 661367006837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 661367006838 GIY-YIG motif/motif A; other site 661367006839 active site 661367006840 catalytic site [active] 661367006841 putative DNA binding site [nucleotide binding]; other site 661367006842 metal binding site [ion binding]; metal-binding site 661367006843 UvrB/uvrC motif; Region: UVR; pfam02151 661367006844 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 661367006845 response regulator; Provisional; Region: PRK09483 661367006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006847 active site 661367006848 phosphorylation site [posttranslational modification] 661367006849 intermolecular recognition site; other site 661367006850 dimerization interface [polypeptide binding]; other site 661367006851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367006852 DNA binding residues [nucleotide binding] 661367006853 dimerization interface [polypeptide binding]; other site 661367006854 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 661367006855 cofactor binding site; other site 661367006856 metal binding site [ion binding]; metal-binding site 661367006857 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367006858 DDE superfamily endonuclease; Region: DDE_3; pfam13358 661367006859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 661367006860 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367006861 active site 661367006862 DNA polymerase IV; Validated; Region: PRK02406 661367006863 DNA binding site [nucleotide binding] 661367006864 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367006865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367006866 Catalytic site [active] 661367006867 GTPase CgtA; Reviewed; Region: obgE; PRK12299 661367006868 GTP1/OBG; Region: GTP1_OBG; pfam01018 661367006869 Obg GTPase; Region: Obg; cd01898 661367006870 G1 box; other site 661367006871 GTP/Mg2+ binding site [chemical binding]; other site 661367006872 Switch I region; other site 661367006873 G2 box; other site 661367006874 G3 box; other site 661367006875 Switch II region; other site 661367006876 G4 box; other site 661367006877 G5 box; other site 661367006878 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 661367006879 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 661367006880 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 661367006881 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 661367006882 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 661367006883 5S rRNA interface [nucleotide binding]; other site 661367006884 CTC domain interface [polypeptide binding]; other site 661367006885 L16 interface [polypeptide binding]; other site 661367006886 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 661367006887 putative active site [active] 661367006888 catalytic residue [active] 661367006889 GTP-binding protein YchF; Reviewed; Region: PRK09601 661367006890 YchF GTPase; Region: YchF; cd01900 661367006891 G1 box; other site 661367006892 GTP/Mg2+ binding site [chemical binding]; other site 661367006893 Switch I region; other site 661367006894 G2 box; other site 661367006895 Switch II region; other site 661367006896 G3 box; other site 661367006897 G4 box; other site 661367006898 G5 box; other site 661367006899 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 661367006900 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 661367006901 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367006902 substrate binding pocket [chemical binding]; other site 661367006903 chain length determination region; other site 661367006904 substrate-Mg2+ binding site; other site 661367006905 catalytic residues [active] 661367006906 aspartate-rich region 1; other site 661367006907 active site lid residues [active] 661367006908 aspartate-rich region 2; other site 661367006909 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006910 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367006911 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006912 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367006913 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 661367006914 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367006915 active site 661367006916 Zn binding site [ion binding]; other site 661367006917 Autoinducer binding domain; Region: Autoind_bind; pfam03472 661367006918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 661367006919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367006920 DNA binding residues [nucleotide binding] 661367006921 dimerization interface [polypeptide binding]; other site 661367006922 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367006923 hypothetical protein; Validated; Region: PRK05868 661367006924 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367006925 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 661367006926 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 661367006927 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367006928 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 661367006929 S1 domain; Region: S1_2; pfam13509 661367006930 S1 domain; Region: S1_2; pfam13509 661367006931 cation transport regulator; Reviewed; Region: chaB; PRK09582 661367006932 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 661367006933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367006934 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 661367006935 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 661367006936 seryl-tRNA synthetase; Provisional; Region: PRK05431 661367006937 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 661367006938 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 661367006939 dimer interface [polypeptide binding]; other site 661367006940 active site 661367006941 motif 1; other site 661367006942 motif 2; other site 661367006943 motif 3; other site 661367006944 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 661367006945 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 661367006946 active site 661367006947 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 661367006948 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 661367006949 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 661367006950 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 661367006951 trimer interface [polypeptide binding]; other site 661367006952 active site 661367006953 UDP-GlcNAc binding site [chemical binding]; other site 661367006954 lipid binding site [chemical binding]; lipid-binding site 661367006955 periplasmic chaperone; Provisional; Region: PRK10780 661367006956 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 661367006957 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 661367006958 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 661367006959 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 661367006960 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 661367006961 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 661367006962 Surface antigen; Region: Bac_surface_Ag; pfam01103 661367006963 zinc metallopeptidase RseP; Provisional; Region: PRK10779 661367006964 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367006965 active site 661367006966 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367006967 protein binding site [polypeptide binding]; other site 661367006968 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367006969 protein binding site [polypeptide binding]; other site 661367006970 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367006971 putative substrate binding region [chemical binding]; other site 661367006972 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 661367006973 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 661367006974 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 661367006975 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 661367006976 catalytic residue [active] 661367006977 putative FPP diphosphate binding site; other site 661367006978 putative FPP binding hydrophobic cleft; other site 661367006979 dimer interface [polypeptide binding]; other site 661367006980 putative IPP diphosphate binding site; other site 661367006981 phosphoglyceromutase; Provisional; Region: PRK05434 661367006982 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 661367006983 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 661367006984 Peptidase family M23; Region: Peptidase_M23; pfam01551 661367006985 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 661367006986 C-terminal peptidase (prc); Region: prc; TIGR00225 661367006987 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 661367006988 protein binding site [polypeptide binding]; other site 661367006989 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 661367006990 Catalytic dyad [active] 661367006991 M48 family peptidase; Provisional; Region: PRK03001 661367006992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 661367006993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 661367006994 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 661367006995 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 661367006996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367006997 active site 661367006998 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 661367006999 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 661367007000 GDP-binding site [chemical binding]; other site 661367007001 ACT binding site; other site 661367007002 IMP binding site; other site 661367007003 FtsH protease regulator HflC; Provisional; Region: PRK11029 661367007004 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 661367007005 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 661367007006 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 661367007007 HflK protein; Region: hflK; TIGR01933 661367007008 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 661367007009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 661367007010 dimer interface [polypeptide binding]; other site 661367007011 active site 661367007012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367007013 substrate binding site [chemical binding]; other site 661367007014 catalytic residue [active] 661367007015 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 661367007016 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007017 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367007018 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 661367007019 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 661367007020 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 661367007021 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 661367007022 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 661367007023 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 661367007024 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 661367007025 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 661367007026 30S subunit binding site; other site 661367007027 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 661367007028 dimerization domain swap beta strand [polypeptide binding]; other site 661367007029 regulatory protein interface [polypeptide binding]; other site 661367007030 active site 661367007031 regulatory phosphorylation site [posttranslational modification]; other site 661367007032 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 661367007033 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 661367007034 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 661367007035 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 661367007036 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 661367007037 FAD binding pocket [chemical binding]; other site 661367007038 FAD binding motif [chemical binding]; other site 661367007039 phosphate binding motif [ion binding]; other site 661367007040 beta-alpha-beta structure motif; other site 661367007041 NAD binding pocket [chemical binding]; other site 661367007042 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 661367007043 active site 661367007044 intersubunit interface [polypeptide binding]; other site 661367007045 catalytic residue [active] 661367007046 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 661367007047 putative catalytic site [active] 661367007048 putative metal binding site [ion binding]; other site 661367007049 putative phosphate binding site [ion binding]; other site 661367007050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 661367007051 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 661367007052 nucleophilic elbow; other site 661367007053 catalytic triad; other site 661367007054 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 661367007055 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 661367007056 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367007057 active site 661367007058 Zn binding site [ion binding]; other site 661367007059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007060 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367007061 putative substrate translocation pore; other site 661367007062 Dehydroquinase class II; Region: DHquinase_II; pfam01220 661367007063 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 661367007064 trimer interface [polypeptide binding]; other site 661367007065 active site 661367007066 dimer interface [polypeptide binding]; other site 661367007067 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 661367007068 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 661367007069 carboxyltransferase (CT) interaction site; other site 661367007070 biotinylation site [posttranslational modification]; other site 661367007071 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 661367007072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367007073 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 661367007074 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 661367007075 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 661367007076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367007077 S-adenosylmethionine binding site [chemical binding]; other site 661367007078 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 661367007079 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 661367007080 purine monophosphate binding site [chemical binding]; other site 661367007081 dimer interface [polypeptide binding]; other site 661367007082 putative catalytic residues [active] 661367007083 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 661367007084 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 661367007085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007086 C factor cell-cell signaling protein; Provisional; Region: PRK09009 661367007087 NAD(P) binding site [chemical binding]; other site 661367007088 active site 661367007089 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 661367007090 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367007091 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 661367007092 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 661367007093 putative acyl-acceptor binding pocket; other site 661367007094 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 661367007095 acyl-activating enzyme (AAE) consensus motif; other site 661367007096 AMP binding site [chemical binding]; other site 661367007097 active site 661367007098 CoA binding site [chemical binding]; other site 661367007099 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 661367007100 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 661367007101 homodimer interface [polypeptide binding]; other site 661367007102 substrate-cofactor binding pocket; other site 661367007103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367007104 catalytic residue [active] 661367007105 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 661367007106 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 661367007107 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 661367007108 Nitrogen regulatory protein P-II; Region: P-II; smart00938 661367007109 Membrane fusogenic activity; Region: BMFP; pfam04380 661367007110 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 661367007111 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 661367007112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367007113 Walker A motif; other site 661367007114 ATP binding site [chemical binding]; other site 661367007115 Walker B motif; other site 661367007116 arginine finger; other site 661367007117 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 661367007118 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 661367007119 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 661367007120 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 661367007121 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 661367007122 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 661367007123 hypothetical protein; Validated; Region: PRK00228 661367007124 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 661367007125 Phosphate transporter family; Region: PHO4; pfam01384 661367007126 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 661367007127 adenosine deaminase; Provisional; Region: PRK09358 661367007128 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 661367007129 active site 661367007130 Bacterial PH domain; Region: DUF304; pfam03703 661367007131 Protein of unknown function (DUF721); Region: DUF721; pfam05258 661367007132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 661367007133 active site 661367007134 motif I; other site 661367007135 motif II; other site 661367007136 Uncharacterized conserved protein [Function unknown]; Region: COG4278 661367007137 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 661367007138 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 661367007139 active site 661367007140 Zn binding site [ion binding]; other site 661367007141 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 661367007142 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 661367007143 cell division protein FtsZ; Validated; Region: PRK09330 661367007144 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 661367007145 nucleotide binding site [chemical binding]; other site 661367007146 SulA interaction site; other site 661367007147 cell division protein FtsA; Region: ftsA; TIGR01174 661367007148 Cell division protein FtsA; Region: FtsA; smart00842 661367007149 Cell division protein FtsA; Region: FtsA; pfam14450 661367007150 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 661367007151 Cell division protein FtsQ; Region: FtsQ; pfam03799 661367007152 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 661367007153 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 661367007154 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367007155 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 661367007156 FAD binding domain; Region: FAD_binding_4; pfam01565 661367007157 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 661367007158 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 661367007159 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367007160 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367007161 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367007162 cell division protein FtsW; Region: ftsW; TIGR02614 661367007163 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 661367007164 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367007165 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367007166 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 661367007167 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 661367007168 Mg++ binding site [ion binding]; other site 661367007169 putative catalytic motif [active] 661367007170 putative substrate binding site [chemical binding]; other site 661367007171 Domain of unknown function (DUF3510); Region: DUF3510; pfam12022 661367007172 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367007173 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 661367007174 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367007175 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367007176 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 661367007177 FtsZ protein binding site [polypeptide binding]; other site 661367007178 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367007179 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 661367007180 Walker A/P-loop; other site 661367007181 ATP binding site [chemical binding]; other site 661367007182 Q-loop/lid; other site 661367007183 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 661367007184 Q-loop/lid; other site 661367007185 ABC transporter signature motif; other site 661367007186 Walker B; other site 661367007187 D-loop; other site 661367007188 H-loop/switch region; other site 661367007189 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 661367007190 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 661367007191 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 661367007192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 661367007193 PspC domain; Region: PspC; pfam04024 661367007194 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 661367007195 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 661367007196 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 661367007197 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 661367007198 dimer interface [polypeptide binding]; other site 661367007199 decamer (pentamer of dimers) interface [polypeptide binding]; other site 661367007200 catalytic triad [active] 661367007201 peroxidatic and resolving cysteines [active] 661367007202 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 661367007203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367007204 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 661367007205 dimerization interface [polypeptide binding]; other site 661367007206 T-complex protein 11; Region: Tcp11; pfam05794 661367007207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367007208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007209 active site 661367007210 phosphorylation site [posttranslational modification] 661367007211 intermolecular recognition site; other site 661367007212 dimerization interface [polypeptide binding]; other site 661367007213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367007214 DNA binding site [nucleotide binding] 661367007215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367007216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367007217 dimer interface [polypeptide binding]; other site 661367007218 phosphorylation site [posttranslational modification] 661367007219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367007220 ATP binding site [chemical binding]; other site 661367007221 Mg2+ binding site [ion binding]; other site 661367007222 G-X-G motif; other site 661367007223 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 661367007224 AAA-like domain; Region: AAA_10; pfam12846 661367007225 HNH nucleases; Region: HNHc; smart00507 661367007226 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007227 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007228 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007229 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007230 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007231 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007232 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007233 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007234 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007235 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367007236 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 661367007237 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 661367007238 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367007239 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367007240 ligand binding site [chemical binding]; other site 661367007241 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 661367007242 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 661367007243 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475 661367007244 Protein of unknown function (DUF3773); Region: DUF3773; pfam12608 661367007245 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 661367007246 DNA-binding site [nucleotide binding]; DNA binding site 661367007247 RNA-binding motif; other site 661367007248 ferrochelatase; Reviewed; Region: hemH; PRK00035 661367007249 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 661367007250 C-terminal domain interface [polypeptide binding]; other site 661367007251 active site 661367007252 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 661367007253 active site 661367007254 N-terminal domain interface [polypeptide binding]; other site 661367007255 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367007256 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367007257 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 661367007258 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 661367007259 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 661367007260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007261 putative substrate translocation pore; other site 661367007262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007263 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 661367007264 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 661367007265 active site 661367007266 intersubunit interface [polypeptide binding]; other site 661367007267 catalytic residue [active] 661367007268 glucokinase; Provisional; Region: glk; PRK00292 661367007269 glucokinase, proteobacterial type; Region: glk; TIGR00749 661367007270 phosphogluconate dehydratase; Validated; Region: PRK09054 661367007271 6-phosphogluconate dehydratase; Region: edd; TIGR01196 661367007272 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 661367007273 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 661367007274 putative active site [active] 661367007275 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 661367007276 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 661367007277 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 661367007278 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 661367007279 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367007280 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 661367007281 RimK-like ATP-grasp domain; Region: RimK; pfam08443 661367007282 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 661367007283 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 661367007284 Cu(I) binding site [ion binding]; other site 661367007285 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 661367007286 UbiA prenyltransferase family; Region: UbiA; pfam01040 661367007287 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 661367007288 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 661367007289 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 661367007290 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 661367007291 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367007292 ATP binding site [chemical binding]; other site 661367007293 Mg++ binding site [ion binding]; other site 661367007294 motif III; other site 661367007295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367007296 nucleotide binding region [chemical binding]; other site 661367007297 ATP-binding site [chemical binding]; other site 661367007298 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 661367007299 putative RNA binding site [nucleotide binding]; other site 661367007300 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367007301 active site 661367007302 catalytic triad [active] 661367007303 oxyanion hole [active] 661367007304 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 661367007305 inner membrane transport permease; Provisional; Region: PRK15066 661367007306 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 661367007307 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367007308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007309 Walker A/P-loop; other site 661367007310 ATP binding site [chemical binding]; other site 661367007311 Q-loop/lid; other site 661367007312 ABC transporter signature motif; other site 661367007313 Walker B; other site 661367007314 D-loop; other site 661367007315 H-loop/switch region; other site 661367007316 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 661367007317 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 661367007318 active site 661367007319 substrate binding site [chemical binding]; other site 661367007320 FMN binding site [chemical binding]; other site 661367007321 putative catalytic residues [active] 661367007322 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367007323 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 661367007324 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 661367007325 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 661367007326 Protein of unknown function DUF45; Region: DUF45; pfam01863 661367007327 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 661367007328 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 661367007329 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 661367007330 RimM N-terminal domain; Region: RimM; pfam01782 661367007331 PRC-barrel domain; Region: PRC; pfam05239 661367007332 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 661367007333 signal recognition particle protein; Provisional; Region: PRK10867 661367007334 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 661367007335 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 661367007336 P loop; other site 661367007337 GTP binding site [chemical binding]; other site 661367007338 Signal peptide binding domain; Region: SRP_SPB; pfam02978 661367007339 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367007340 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 661367007341 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 661367007342 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 661367007343 active site 661367007344 FMN binding site [chemical binding]; other site 661367007345 2,4-decadienoyl-CoA binding site; other site 661367007346 catalytic residue [active] 661367007347 4Fe-4S cluster binding site [ion binding]; other site 661367007348 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 661367007349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367007350 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 661367007351 EamA-like transporter family; Region: EamA; pfam00892 661367007352 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 661367007353 malate dehydrogenase; Provisional; Region: PRK05442 661367007354 NAD(P) binding site [chemical binding]; other site 661367007355 dimer interface [polypeptide binding]; other site 661367007356 malate binding site [chemical binding]; other site 661367007357 HemN family oxidoreductase; Provisional; Region: PRK05660 661367007358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367007359 FeS/SAM binding site; other site 661367007360 HemN C-terminal domain; Region: HemN_C; pfam06969 661367007361 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 661367007362 UGMP family protein; Validated; Region: PRK09604 661367007363 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 661367007364 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 661367007365 Yqey-like protein; Region: YqeY; pfam09424 661367007366 DNA primase; Validated; Region: dnaG; PRK05667 661367007367 CHC2 zinc finger; Region: zf-CHC2; pfam01807 661367007368 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 661367007369 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 661367007370 active site 661367007371 metal binding site [ion binding]; metal-binding site 661367007372 interdomain interaction site; other site 661367007373 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 661367007374 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 661367007375 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 661367007376 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 661367007377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367007378 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 661367007379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367007380 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367007381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367007382 DNA binding residues [nucleotide binding] 661367007383 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 661367007384 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367007385 active site 661367007386 DNA binding site [nucleotide binding] 661367007387 Int/Topo IB signature motif; other site 661367007388 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 661367007389 active site 661367007390 homodimer interface [polypeptide binding]; other site 661367007391 SAM binding site [chemical binding]; other site 661367007392 POT family; Region: PTR2; cl17359 661367007393 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 661367007394 DNA binding domain, excisionase family; Region: excise; TIGR01764 661367007395 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 661367007396 HsdM N-terminal domain; Region: HsdM_N; pfam12161 661367007397 Methyltransferase domain; Region: Methyltransf_26; pfam13659 661367007398 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 661367007399 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 661367007400 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 661367007401 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 661367007402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367007403 ATP binding site [chemical binding]; other site 661367007404 putative Mg++ binding site [ion binding]; other site 661367007405 AAA domain; Region: AAA_13; pfam13166 661367007406 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 661367007407 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 661367007408 active site 661367007409 metal binding site [ion binding]; metal-binding site 661367007410 DNA binding site [nucleotide binding] 661367007411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 661367007412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007413 Walker A/P-loop; other site 661367007414 ATP binding site [chemical binding]; other site 661367007415 Q-loop/lid; other site 661367007416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007417 non-specific DNA binding site [nucleotide binding]; other site 661367007418 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367007419 salt bridge; other site 661367007420 sequence-specific DNA binding site [nucleotide binding]; other site 661367007421 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367007422 Catalytic site [active] 661367007423 Global regulator protein family; Region: CsrA; pfam02599 661367007424 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 661367007425 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 661367007426 ATP binding site [chemical binding]; other site 661367007427 Walker A motif; other site 661367007428 hexamer interface [polypeptide binding]; other site 661367007429 Walker B motif; other site 661367007430 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 661367007432 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007433 TrbC/VIRB2 family; Region: TrbC; cl01583 661367007434 conjugal transfer protein TrbD; Provisional; Region: PRK13823 661367007435 conjugal transfer protein TrbE; Provisional; Region: PRK13891 661367007436 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 661367007437 conjugal transfer protein TrbF; Provisional; Region: PRK13887 661367007438 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 661367007439 VirB7 interaction site; other site 661367007440 conjugal transfer protein TrbH; Provisional; Region: PRK13883 661367007441 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 661367007442 conjugal transfer protein TrbI; Provisional; Region: PRK13881 661367007443 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 661367007444 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 661367007445 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 661367007446 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 661367007447 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367007448 Walker A motif; other site 661367007449 ATP binding site [chemical binding]; other site 661367007450 Walker B motif; other site 661367007451 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 661367007452 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 661367007453 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 661367007454 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 661367007455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 661367007456 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 661367007457 active site 661367007458 metal binding site [ion binding]; metal-binding site 661367007459 interdomain interaction site; other site 661367007460 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 661367007461 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 661367007462 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 661367007463 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 661367007464 P-loop; other site 661367007465 Transcriptional activator TraM; Region: Activator-TraM; pfam11657 661367007466 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 661367007467 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 661367007468 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367007469 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 661367007470 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 661367007471 putative active site [active] 661367007472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 661367007473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007474 Walker A/P-loop; other site 661367007475 ATP binding site [chemical binding]; other site 661367007476 Q-loop/lid; other site 661367007477 ABC transporter signature motif; other site 661367007478 Walker B; other site 661367007479 D-loop; other site 661367007480 H-loop/switch region; other site 661367007481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367007482 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367007483 HEAT repeats; Region: HEAT_2; pfam13646 661367007484 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 661367007485 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 661367007487 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007489 Walker A/P-loop; other site 661367007490 ATP binding site [chemical binding]; other site 661367007491 ABC transporter; Region: ABC_tran; pfam00005 661367007492 Q-loop/lid; other site 661367007493 ABC transporter signature motif; other site 661367007494 Walker B; other site 661367007495 D-loop; other site 661367007496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367007497 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 661367007499 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 661367007501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007502 salt bridge; other site 661367007503 non-specific DNA binding site [nucleotide binding]; other site 661367007504 sequence-specific DNA binding site [nucleotide binding]; other site 661367007505 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367007506 Catalytic site [active] 661367007507 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 661367007508 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 661367007509 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 661367007510 ATP binding site [chemical binding]; other site 661367007511 substrate interface [chemical binding]; other site 661367007512 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367007513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367007515 putative substrate translocation pore; other site 661367007516 aconitate hydratase; Validated; Region: PRK09277 661367007517 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367007518 substrate binding site [chemical binding]; other site 661367007519 ligand binding site [chemical binding]; other site 661367007520 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367007521 substrate binding site [chemical binding]; other site 661367007522 Uncharacterized conserved protein [Function unknown]; Region: COG3189 661367007523 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 661367007524 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 661367007525 FAD binding pocket [chemical binding]; other site 661367007526 conserved FAD binding motif [chemical binding]; other site 661367007527 phosphate binding motif [ion binding]; other site 661367007528 beta-alpha-beta structure motif; other site 661367007529 NAD binding pocket [chemical binding]; other site 661367007530 OsmC-like protein; Region: OsmC; cl00767 661367007531 Protein of unknown function, DUF488; Region: DUF488; pfam04343 661367007532 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007533 Ligand Binding Site [chemical binding]; other site 661367007534 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007535 Ligand Binding Site [chemical binding]; other site 661367007536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007537 Ligand Binding Site [chemical binding]; other site 661367007538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007539 Ligand Binding Site [chemical binding]; other site 661367007540 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 661367007541 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 661367007542 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 661367007543 putative dimer interface [polypeptide binding]; other site 661367007544 N-terminal domain interface [polypeptide binding]; other site 661367007545 putative substrate binding pocket (H-site) [chemical binding]; other site 661367007546 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007547 Ligand Binding Site [chemical binding]; other site 661367007548 putative cation:proton antiport protein; Provisional; Region: PRK10669 661367007549 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367007550 TrkA-N domain; Region: TrkA_N; pfam02254 661367007551 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 661367007552 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 661367007553 putative active site [active] 661367007554 metal binding site [ion binding]; metal-binding site 661367007555 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367007556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367007557 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367007558 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 661367007559 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 661367007560 Domain of unknown function (DUF927); Region: DUF927; pfam06048 661367007561 Helix-turn-helix domain; Region: HTH_17; cl17695 661367007562 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 661367007563 AAA domain; Region: AAA_14; pfam13173 661367007564 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367007565 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367007566 active site 661367007567 metal binding site [ion binding]; metal-binding site 661367007568 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 661367007569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367007570 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367007571 active site 661367007572 DNA binding site [nucleotide binding] 661367007573 Int/Topo IB signature motif; other site 661367007574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367007575 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367007576 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007577 Ligand Binding Site [chemical binding]; other site 661367007578 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007579 Ligand Binding Site [chemical binding]; other site 661367007580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007581 non-specific DNA binding site [nucleotide binding]; other site 661367007582 salt bridge; other site 661367007583 sequence-specific DNA binding site [nucleotide binding]; other site 661367007584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 661367007585 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 661367007586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007587 putative substrate translocation pore; other site 661367007588 acyl-CoA synthetase; Validated; Region: PRK09192 661367007589 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 661367007590 acyl-activating enzyme (AAE) consensus motif; other site 661367007591 active site 661367007592 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 661367007593 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 661367007594 putative acyl-acceptor binding pocket; other site 661367007595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367007596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 661367007597 ABC-ATPase subunit interface; other site 661367007598 dimer interface [polypeptide binding]; other site 661367007599 putative PBP binding regions; other site 661367007600 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 661367007601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007602 Walker A/P-loop; other site 661367007603 ATP binding site [chemical binding]; other site 661367007604 Q-loop/lid; other site 661367007605 ABC transporter signature motif; other site 661367007606 Walker B; other site 661367007607 D-loop; other site 661367007608 H-loop/switch region; other site 661367007609 Predicted membrane protein [Function unknown]; Region: COG3174 661367007610 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 661367007611 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367007612 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367007613 putative dimer interface [polypeptide binding]; other site 661367007614 mercuric reductase; Validated; Region: PRK06370 661367007615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 661367007616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367007617 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367007618 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 661367007619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367007620 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367007621 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 661367007622 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 661367007623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 661367007624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 661367007625 catalytic core [active] 661367007626 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367007627 substrate binding site [chemical binding]; other site 661367007628 activation loop (A-loop); other site 661367007629 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 661367007630 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 661367007631 hypothetical protein; Provisional; Region: PRK05713 661367007632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 661367007633 catalytic loop [active] 661367007634 iron binding site [ion binding]; other site 661367007635 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 661367007636 FAD binding pocket [chemical binding]; other site 661367007637 FAD binding motif [chemical binding]; other site 661367007638 phosphate binding motif [ion binding]; other site 661367007639 beta-alpha-beta structure motif; other site 661367007640 NAD binding pocket [chemical binding]; other site 661367007641 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 661367007642 apolar tunnel; other site 661367007643 heme binding site [chemical binding]; other site 661367007644 dimerization interface [polypeptide binding]; other site 661367007645 Transcriptional regulator; Region: Rrf2; cl17282 661367007646 Rrf2 family protein; Region: rrf2_super; TIGR00738 661367007647 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 661367007648 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367007649 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 661367007650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367007651 catalytic residue [active] 661367007652 MarC family integral membrane protein; Region: MarC; cl00919 661367007653 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 661367007654 peptidase domain interface [polypeptide binding]; other site 661367007655 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 661367007656 active site 661367007657 catalytic triad [active] 661367007658 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 661367007659 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 661367007660 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 661367007661 active site 661367007662 substrate binding site [chemical binding]; other site 661367007663 cosubstrate binding site; other site 661367007664 catalytic site [active] 661367007665 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 661367007666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 661367007667 Interdomain contacts; other site 661367007668 Cytokine receptor motif; other site 661367007669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367007670 classical (c) SDRs; Region: SDR_c; cd05233 661367007671 NAD(P) binding site [chemical binding]; other site 661367007672 active site 661367007673 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 661367007674 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 661367007675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 661367007676 Walker A/P-loop; other site 661367007677 ATP binding site [chemical binding]; other site 661367007678 Q-loop/lid; other site 661367007679 ABC transporter signature motif; other site 661367007680 Walker B; other site 661367007681 D-loop; other site 661367007682 H-loop/switch region; other site 661367007683 ABC transporter; Region: ABC_tran_2; pfam12848 661367007684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 661367007685 DDE superfamily endonuclease; Region: DDE_5; cl17874 661367007686 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367007687 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 661367007688 Repeats found in Drosophila proteins; Region: DM9; smart00696 661367007689 FkbH-like domain; Region: FkbH; TIGR01686 661367007690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367007691 active site 661367007692 motif I; other site 661367007693 motif II; other site 661367007694 short chain dehydrogenase; Provisional; Region: PRK06180 661367007695 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 661367007696 NADP binding site [chemical binding]; other site 661367007697 active site 661367007698 steroid binding site; other site 661367007699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367007700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367007701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367007702 dimerization interface [polypeptide binding]; other site 661367007703 ornithine carbamoyltransferase; Provisional; Region: PRK00779 661367007704 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 661367007705 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 661367007706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367007707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367007708 substrate binding pocket [chemical binding]; other site 661367007709 membrane-bound complex binding site; other site 661367007710 hinge residues; other site 661367007711 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 661367007712 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 661367007713 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 661367007714 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 661367007715 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 661367007716 putative active site [active] 661367007717 putative catalytic site [active] 661367007718 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 661367007719 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 661367007720 putative active site [active] 661367007721 putative dimer interface [polypeptide binding]; other site 661367007722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367007723 PGAP1-like protein; Region: PGAP1; pfam07819 661367007724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 661367007725 FAD binding domain; Region: FAD_binding_4; pfam01565 661367007726 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 661367007727 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367007728 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367007729 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367007730 PAS fold; Region: PAS_7; pfam12860 661367007731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007732 PAS domain; Region: PAS_9; pfam13426 661367007733 putative active site [active] 661367007734 heme pocket [chemical binding]; other site 661367007735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367007736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007737 metal binding site [ion binding]; metal-binding site 661367007738 active site 661367007739 I-site; other site 661367007740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367007741 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 661367007742 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 661367007743 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 661367007744 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 661367007745 putative NADH binding site [chemical binding]; other site 661367007746 putative active site [active] 661367007747 nudix motif; other site 661367007748 putative metal binding site [ion binding]; other site 661367007749 O-methyltransferase; Region: Methyltransf_2; pfam00891 661367007750 LysE type translocator; Region: LysE; cl00565 661367007751 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 661367007752 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 661367007753 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367007754 active site 661367007755 ATP binding site [chemical binding]; other site 661367007756 substrate binding site [chemical binding]; other site 661367007757 activation loop (A-loop); other site 661367007758 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 661367007759 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 661367007760 Ligand binding site; other site 661367007761 Putative Catalytic site; other site 661367007762 DXD motif; other site 661367007763 GtrA-like protein; Region: GtrA; pfam04138 661367007764 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 661367007765 CrcB-like protein; Region: CRCB; cl09114 661367007766 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 661367007767 putative active site [active] 661367007768 YdjC motif; other site 661367007769 Mg binding site [ion binding]; other site 661367007770 putative homodimer interface [polypeptide binding]; other site 661367007771 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 661367007772 EamA-like transporter family; Region: EamA; pfam00892 661367007773 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 661367007774 active site 661367007775 dimerization interface [polypeptide binding]; other site 661367007776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007777 Tetratricopeptide repeat; Region: TPR_16; pfam13432 661367007778 binding surface 661367007779 TPR motif; other site 661367007780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007781 binding surface 661367007782 TPR motif; other site 661367007783 TPR repeat; Region: TPR_11; pfam13414 661367007784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007785 binding surface 661367007786 TPR motif; other site 661367007787 TPR repeat; Region: TPR_11; pfam13414 661367007788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007789 binding surface 661367007790 TPR motif; other site 661367007791 TPR repeat; Region: TPR_11; pfam13414 661367007792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007793 binding surface 661367007794 TPR motif; other site 661367007795 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 661367007796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367007797 PAS fold; Region: PAS_4; pfam08448 661367007798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 661367007799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367007800 DNA binding residues [nucleotide binding] 661367007801 dimerization interface [polypeptide binding]; other site 661367007802 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367007803 TrkA-N domain; Region: TrkA_N; pfam02254 661367007804 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 661367007805 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 661367007806 active site 661367007807 substrate binding site [chemical binding]; other site 661367007808 metal binding site [ion binding]; metal-binding site 661367007809 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 661367007810 trimer interface [polypeptide binding]; other site 661367007811 active site 661367007812 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 661367007813 Flavoprotein; Region: Flavoprotein; pfam02441 661367007814 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 661367007815 hypothetical protein; Reviewed; Region: PRK00024 661367007816 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 661367007817 MPN+ (JAMM) motif; other site 661367007818 Zinc-binding site [ion binding]; other site 661367007819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 661367007820 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 661367007821 motif 1; other site 661367007822 dimer interface [polypeptide binding]; other site 661367007823 active site 661367007824 motif 2; other site 661367007825 motif 3; other site 661367007826 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 661367007827 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 661367007828 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 661367007829 trimerization site [polypeptide binding]; other site 661367007830 active site 661367007831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367007832 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 661367007833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367007834 catalytic residue [active] 661367007835 FeS assembly protein SufD; Region: sufD; TIGR01981 661367007836 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 661367007837 FeS assembly ATPase SufC; Region: sufC; TIGR01978 661367007838 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 661367007839 Walker A/P-loop; other site 661367007840 ATP binding site [chemical binding]; other site 661367007841 Q-loop/lid; other site 661367007842 ABC transporter signature motif; other site 661367007843 Walker B; other site 661367007844 D-loop; other site 661367007845 H-loop/switch region; other site 661367007846 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 661367007847 putative ABC transporter; Region: ycf24; CHL00085 661367007848 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 661367007849 Transcriptional regulator; Region: Rrf2; pfam02082 661367007850 Transcriptional regulator; Region: Rrf2; cl17282 661367007851 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 661367007852 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 661367007853 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 661367007854 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 661367007855 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 661367007856 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367007857 active site 661367007858 nucleophile elbow; other site 661367007859 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367007860 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367007861 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367007862 putative binding surface; other site 661367007863 active site 661367007864 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007866 active site 661367007867 phosphorylation site [posttranslational modification] 661367007868 intermolecular recognition site; other site 661367007869 dimerization interface [polypeptide binding]; other site 661367007870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367007871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007872 metal binding site [ion binding]; metal-binding site 661367007873 active site 661367007874 I-site; other site 661367007875 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007877 active site 661367007878 phosphorylation site [posttranslational modification] 661367007879 intermolecular recognition site; other site 661367007880 dimerization interface [polypeptide binding]; other site 661367007881 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 661367007882 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007883 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007884 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007885 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 661367007886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007887 putative active site [active] 661367007888 heme pocket [chemical binding]; other site 661367007889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367007890 dimer interface [polypeptide binding]; other site 661367007891 phosphorylation site [posttranslational modification] 661367007892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367007893 ATP binding site [chemical binding]; other site 661367007894 Mg2+ binding site [ion binding]; other site 661367007895 G-X-G motif; other site 661367007896 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007898 active site 661367007899 phosphorylation site [posttranslational modification] 661367007900 intermolecular recognition site; other site 661367007901 dimerization interface [polypeptide binding]; other site 661367007902 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007904 active site 661367007905 phosphorylation site [posttranslational modification] 661367007906 intermolecular recognition site; other site 661367007907 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 661367007908 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 661367007909 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 661367007910 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 661367007911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367007912 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 661367007913 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 661367007914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367007915 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367007916 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 661367007917 IMP binding site; other site 661367007918 dimer interface [polypeptide binding]; other site 661367007919 interdomain contacts; other site 661367007920 partial ornithine binding site; other site 661367007921 Predicted flavoproteins [General function prediction only]; Region: COG2081 661367007922 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 661367007923 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007924 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 661367007925 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007926 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367007927 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367007928 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007929 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367007930 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007931 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007932 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367007933 hypothetical protein; Provisional; Region: PRK11212 661367007934 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007935 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 661367007936 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007937 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 661367007938 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 661367007939 active site 661367007940 purine riboside binding site [chemical binding]; other site 661367007941 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 661367007942 FAD binding domain; Region: FAD_binding_3; pfam01494 661367007943 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367007944 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 661367007945 amidase catalytic site [active] 661367007946 Zn binding residues [ion binding]; other site 661367007947 substrate binding site [chemical binding]; other site 661367007948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367007949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367007950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367007951 dimerization interface [polypeptide binding]; other site 661367007952 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 661367007953 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 661367007954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367007955 Walker A motif; other site 661367007956 ATP binding site [chemical binding]; other site 661367007957 Walker B motif; other site 661367007958 arginine finger; other site 661367007959 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 661367007960 PQ loop repeat; Region: PQ-loop; pfam04193 661367007961 Thiamine pyrophosphokinase; Region: TPK; cd07995 661367007962 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 661367007963 active site 661367007964 dimerization interface [polypeptide binding]; other site 661367007965 thiamine binding site [chemical binding]; other site 661367007966 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 661367007967 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 661367007968 ArsC family; Region: ArsC; pfam03960 661367007969 catalytic residues [active] 661367007970 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367007971 Leucine-rich repeats; other site 661367007972 Substrate binding site [chemical binding]; other site 661367007973 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367007974 Leucine-rich repeats; other site 661367007975 Substrate binding site [chemical binding]; other site 661367007976 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367007977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367007979 putative substrate translocation pore; other site 661367007980 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 661367007981 MltA specific insert domain; Region: MltA; smart00925 661367007982 3D domain; Region: 3D; pfam06725 661367007983 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 661367007984 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 661367007985 putative NAD(P) binding site [chemical binding]; other site 661367007986 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007988 active site 661367007989 phosphorylation site [posttranslational modification] 661367007990 intermolecular recognition site; other site 661367007991 dimerization interface [polypeptide binding]; other site 661367007992 PAS domain S-box; Region: sensory_box; TIGR00229 661367007993 PAS domain; Region: PAS; smart00091 661367007994 putative active site [active] 661367007995 heme pocket [chemical binding]; other site 661367007996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367007997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007998 metal binding site [ion binding]; metal-binding site 661367007999 active site 661367008000 I-site; other site 661367008001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367008002 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 661367008003 aromatic acid decarboxylase; Validated; Region: PRK05920 661367008004 Flavoprotein; Region: Flavoprotein; pfam02441 661367008005 IucA / IucC family; Region: IucA_IucC; pfam04183 661367008006 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 661367008007 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367008008 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 661367008009 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367008010 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 661367008011 Y-family of DNA polymerases; Region: PolY; cl12025 661367008012 acetolactate synthase; Reviewed; Region: PRK08322 661367008013 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 661367008014 PYR/PP interface [polypeptide binding]; other site 661367008015 dimer interface [polypeptide binding]; other site 661367008016 TPP binding site [chemical binding]; other site 661367008017 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 661367008018 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 661367008019 TPP-binding site [chemical binding]; other site 661367008020 dimer interface [polypeptide binding]; other site 661367008021 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367008022 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 661367008023 NAD(P) binding site [chemical binding]; other site 661367008024 catalytic residues [active] 661367008025 Glutaminase; Region: Glutaminase; cl00907 661367008026 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 661367008027 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 661367008028 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 661367008029 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 661367008030 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 661367008031 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 661367008032 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 661367008033 Substrate binding site; other site 661367008034 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 661367008035 polysaccharide export protein Wza; Provisional; Region: PRK15078 661367008036 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 661367008037 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 661367008038 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 661367008039 Walker A/P-loop; other site 661367008040 ATP binding site [chemical binding]; other site 661367008041 Q-loop/lid; other site 661367008042 ABC transporter signature motif; other site 661367008043 Walker B; other site 661367008044 D-loop; other site 661367008045 H-loop/switch region; other site 661367008046 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 661367008047 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 661367008048 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 661367008049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367008050 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367008051 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 661367008052 putative ADP-binding pocket [chemical binding]; other site 661367008053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367008054 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 661367008055 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 661367008056 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 661367008057 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 661367008058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367008059 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367008060 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 661367008061 Protein of unknown function (DUF972); Region: DUF972; pfam06156 661367008062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 661367008063 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 661367008064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367008065 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 661367008066 active site 661367008067 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 661367008068 ligand binding site; other site 661367008069 tetramer interface; other site 661367008070 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 661367008071 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 661367008072 putative ligand binding site [chemical binding]; other site 661367008073 putative NAD binding site [chemical binding]; other site 661367008074 catalytic site [active] 661367008075 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 661367008076 classical (c) SDRs; Region: SDR_c; cd05233 661367008077 NAD(P) binding site [chemical binding]; other site 661367008078 active site 661367008079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 661367008080 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 661367008081 UDP-glucose 4-epimerase; Region: PLN02240 661367008082 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 661367008083 NAD binding site [chemical binding]; other site 661367008084 homodimer interface [polypeptide binding]; other site 661367008085 active site 661367008086 substrate binding site [chemical binding]; other site 661367008087 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 661367008088 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 661367008089 NADP-binding site; other site 661367008090 homotetramer interface [polypeptide binding]; other site 661367008091 substrate binding site [chemical binding]; other site 661367008092 homodimer interface [polypeptide binding]; other site 661367008093 active site 661367008094 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 661367008095 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 661367008096 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 661367008097 active site 661367008098 tetramer interface; other site 661367008099 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 661367008100 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 661367008101 NAD binding site [chemical binding]; other site 661367008102 homodimer interface [polypeptide binding]; other site 661367008103 active site 661367008104 substrate binding site [chemical binding]; other site 661367008105 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 661367008106 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 661367008107 NADP binding site [chemical binding]; other site 661367008108 active site 661367008109 putative substrate binding site [chemical binding]; other site 661367008110 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367008111 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 661367008112 metal-binding site 661367008113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008114 NAD(P) binding site [chemical binding]; other site 661367008115 active site 661367008116 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 661367008117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367008118 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 661367008119 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 661367008120 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 661367008121 substrate-cofactor binding pocket; other site 661367008122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008123 catalytic residue [active] 661367008124 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367008125 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 661367008126 active site 661367008127 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 661367008128 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 661367008129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008130 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 661367008131 Enoylreductase; Region: PKS_ER; smart00829 661367008132 NAD(P) binding site [chemical binding]; other site 661367008133 KR domain; Region: KR; pfam08659 661367008134 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367008135 putative NADP binding site [chemical binding]; other site 661367008136 active site 661367008137 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 661367008138 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367008139 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 661367008140 putative NAD(P) binding site [chemical binding]; other site 661367008141 active site 661367008142 putative substrate binding site [chemical binding]; other site 661367008143 hypothetical protein; Provisional; Region: PRK06489 661367008144 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 661367008145 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 661367008146 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 661367008147 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008149 active site 661367008150 phosphorylation site [posttranslational modification] 661367008151 intermolecular recognition site; other site 661367008152 dimerization interface [polypeptide binding]; other site 661367008153 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 661367008154 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 661367008155 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367008156 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367008157 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367008158 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 661367008159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008160 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367008161 putative substrate translocation pore; other site 661367008162 gamma-glutamyl kinase; Provisional; Region: PRK05429 661367008163 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 661367008164 nucleotide binding site [chemical binding]; other site 661367008165 homotetrameric interface [polypeptide binding]; other site 661367008166 putative phosphate binding site [ion binding]; other site 661367008167 putative allosteric binding site; other site 661367008168 PUA domain; Region: PUA; pfam01472 661367008169 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 661367008170 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 661367008171 putative catalytic cysteine [active] 661367008172 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367008173 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367008174 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 661367008175 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 661367008176 NAD binding site [chemical binding]; other site 661367008177 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 661367008178 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 661367008179 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 661367008180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367008181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367008182 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367008183 putative effector binding pocket; other site 661367008184 dimerization interface [polypeptide binding]; other site 661367008185 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 661367008186 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367008187 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367008188 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 661367008189 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 661367008190 Methyltransferase domain; Region: Methyltransf_31; pfam13847 661367008191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367008192 S-adenosylmethionine binding site [chemical binding]; other site 661367008193 Maf-like protein; Region: Maf; pfam02545 661367008194 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 661367008195 active site 661367008196 dimer interface [polypeptide binding]; other site 661367008197 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 661367008198 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 661367008199 active site 661367008200 nucleophile elbow; other site 661367008201 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367008202 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367008203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 661367008204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367008205 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 661367008206 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 661367008207 active site 661367008208 dimer interface [polypeptide binding]; other site 661367008209 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 661367008210 Ligand Binding Site [chemical binding]; other site 661367008211 Molecular Tunnel; other site 661367008212 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367008213 ArsC family; Region: ArsC; pfam03960 661367008214 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 661367008215 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 661367008216 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 661367008217 transmembrane helices; other site 661367008218 Hemerythrin-like domain; Region: Hr-like; cd12108 661367008219 Fe binding site [ion binding]; other site 661367008220 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 661367008221 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367008222 active site 661367008223 NTP binding site [chemical binding]; other site 661367008224 metal binding triad [ion binding]; metal-binding site 661367008225 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367008226 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367008227 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367008228 putative dimer interface [polypeptide binding]; other site 661367008229 Methyltransferase domain; Region: Methyltransf_25; pfam13649 661367008230 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 661367008231 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 661367008232 trimer interface [polypeptide binding]; other site 661367008233 putative Zn binding site [ion binding]; other site 661367008234 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 661367008235 transmembrane helices; other site 661367008236 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 661367008237 TrkA-C domain; Region: TrkA_C; pfam02080 661367008238 TrkA-C domain; Region: TrkA_C; pfam02080 661367008239 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 661367008240 Cupin domain; Region: Cupin_2; pfam07883 661367008241 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 661367008242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367008243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367008244 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 661367008245 putative dimerization interface [polypeptide binding]; other site 661367008246 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 661367008247 LrgB-like family; Region: LrgB; pfam04172 661367008248 Cation efflux family; Region: Cation_efflux; cl00316 661367008249 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 661367008250 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367008251 ATP binding site [chemical binding]; other site 661367008252 Mg++ binding site [ion binding]; other site 661367008253 motif III; other site 661367008254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367008255 nucleotide binding region [chemical binding]; other site 661367008256 ATP-binding site [chemical binding]; other site 661367008257 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 661367008258 putative RNA binding site [nucleotide binding]; other site 661367008259 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 661367008260 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 661367008261 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 661367008262 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 661367008263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367008265 putative substrate translocation pore; other site 661367008266 PAS domain S-box; Region: sensory_box; TIGR00229 661367008267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367008268 putative active site [active] 661367008269 heme pocket [chemical binding]; other site 661367008270 PAS domain S-box; Region: sensory_box; TIGR00229 661367008271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367008272 putative active site [active] 661367008273 heme pocket [chemical binding]; other site 661367008274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367008275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008276 metal binding site [ion binding]; metal-binding site 661367008277 active site 661367008278 I-site; other site 661367008279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367008280 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367008281 active site 661367008282 nucleophile elbow; other site 661367008283 Uncharacterized conserved protein [Function unknown]; Region: COG2128 661367008284 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 661367008285 Family description; Region: VCBS; pfam13517 661367008286 Family description; Region: VCBS; pfam13517 661367008287 Family description; Region: VCBS; pfam13517 661367008288 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 661367008289 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 661367008290 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 661367008291 active site 661367008292 Zn binding site [ion binding]; other site 661367008293 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 661367008294 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 661367008295 TPP-binding site [chemical binding]; other site 661367008296 dimer interface [polypeptide binding]; other site 661367008297 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 661367008298 PYR/PP interface [polypeptide binding]; other site 661367008299 dimer interface [polypeptide binding]; other site 661367008300 TPP binding site [chemical binding]; other site 661367008301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367008302 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 661367008303 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 661367008304 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 661367008305 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 661367008306 Phosphoglycerate kinase; Region: PGK; pfam00162 661367008307 substrate binding site [chemical binding]; other site 661367008308 hinge regions; other site 661367008309 ADP binding site [chemical binding]; other site 661367008310 catalytic site [active] 661367008311 pyruvate kinase; Provisional; Region: PRK05826 661367008312 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 661367008313 domain interfaces; other site 661367008314 active site 661367008315 ProQ/FINO family; Region: ProQ; pfam04352 661367008316 putative RNA binding sites [nucleotide binding]; other site 661367008317 dihydrodipicolinate reductase; Provisional; Region: PRK00048 661367008318 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 661367008319 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 661367008320 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 661367008321 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 661367008322 tetrameric interface [polypeptide binding]; other site 661367008323 NAD binding site [chemical binding]; other site 661367008324 catalytic residues [active] 661367008325 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 661367008326 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 661367008327 acetyl-CoA synthetase; Provisional; Region: PRK00174 661367008328 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 661367008329 active site 661367008330 CoA binding site [chemical binding]; other site 661367008331 acyl-activating enzyme (AAE) consensus motif; other site 661367008332 AMP binding site [chemical binding]; other site 661367008333 acetate binding site [chemical binding]; other site 661367008334 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 661367008335 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 661367008336 dimerization interface [polypeptide binding]; other site 661367008337 ATP binding site [chemical binding]; other site 661367008338 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 661367008339 dimerization interface [polypeptide binding]; other site 661367008340 ATP binding site [chemical binding]; other site 661367008341 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 661367008342 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 661367008343 dimerization interface [polypeptide binding]; other site 661367008344 putative ATP binding site [chemical binding]; other site 661367008345 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 661367008346 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 661367008347 conserved cys residue [active] 661367008348 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 661367008349 active site 661367008350 ATP binding site [chemical binding]; other site 661367008351 substrate binding site [chemical binding]; other site 661367008352 amidophosphoribosyltransferase; Provisional; Region: PRK09246 661367008353 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 661367008354 active site 661367008355 tetramer interface [polypeptide binding]; other site 661367008356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367008357 active site 661367008358 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 661367008359 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 661367008360 ATP-grasp domain; Region: ATP-grasp_4; cl17255 661367008361 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 661367008362 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 661367008363 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 661367008364 active site 661367008365 substrate binding site [chemical binding]; other site 661367008366 cosubstrate binding site; other site 661367008367 catalytic site [active] 661367008368 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 661367008369 Fic/DOC family; Region: Fic; cl00960 661367008370 high affinity sulphate transporter 1; Region: sulP; TIGR00815 661367008371 Sulfate transporter family; Region: Sulfate_transp; pfam00916 661367008372 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367008373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367008374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367008375 ligand binding site [chemical binding]; other site 661367008376 flexible hinge region; other site 661367008377 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 661367008378 G1 box; other site 661367008379 GTP/Mg2+ binding site [chemical binding]; other site 661367008380 Switch I region; other site 661367008381 G2 box; other site 661367008382 G3 box; other site 661367008383 Switch II region; other site 661367008384 G4 box; other site 661367008385 G5 box; other site 661367008386 Cytochrome c553 [Energy production and conversion]; Region: COG2863 661367008387 Cytochrome c; Region: Cytochrom_C; cl11414 661367008388 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 661367008389 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 661367008390 catalytic residues [active] 661367008391 hinge region; other site 661367008392 alpha helical domain; other site 661367008393 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 661367008394 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 661367008395 Rab subfamily motif 1 (RabSF1); other site 661367008396 G1 box; other site 661367008397 GTP/Mg2+ binding site [chemical binding]; other site 661367008398 Rab subfamily motif 2 (RabSF2); other site 661367008399 Switch I region; other site 661367008400 G2 box; other site 661367008401 effector interaction site; other site 661367008402 GDI interaction site; other site 661367008403 Rab family motif 1 (RabF1); other site 661367008404 GEF interaction site [polypeptide binding]; other site 661367008405 Rab family motif 2 (RabF2); other site 661367008406 G3 box; other site 661367008407 Switch II region; other site 661367008408 Rab family motif 3 (RabF3); other site 661367008409 Rab family motif 4 (RabF4); other site 661367008410 Rab family motif 5 (RabF5); other site 661367008411 Rab subfamily motif 3 (RabSF3); other site 661367008412 G4 box; other site 661367008413 G5 box; other site 661367008414 Rab subfamily motif 4 (RabSF4); other site 661367008415 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 661367008416 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 661367008417 Walker A/P-loop; other site 661367008418 ATP binding site [chemical binding]; other site 661367008419 Q-loop/lid; other site 661367008420 ABC transporter signature motif; other site 661367008421 Walker B; other site 661367008422 D-loop; other site 661367008423 H-loop/switch region; other site 661367008424 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 661367008425 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 661367008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367008427 dimer interface [polypeptide binding]; other site 661367008428 conserved gate region; other site 661367008429 putative PBP binding loops; other site 661367008430 ABC-ATPase subunit interface; other site 661367008431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367008432 dimer interface [polypeptide binding]; other site 661367008433 conserved gate region; other site 661367008434 putative PBP binding loops; other site 661367008435 ABC-ATPase subunit interface; other site 661367008436 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367008437 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 661367008438 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 661367008439 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 661367008440 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 661367008441 lipoyl attachment site [posttranslational modification]; other site 661367008442 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 661367008443 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 661367008444 tetramer interface [polypeptide binding]; other site 661367008445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008446 catalytic residue [active] 661367008447 YCII-related domain; Region: YCII; cl00999 661367008448 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 661367008449 tetramer interface [polypeptide binding]; other site 661367008450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008451 catalytic residue [active] 661367008452 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 661367008453 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 661367008454 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 661367008455 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 661367008456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367008457 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367008458 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 661367008459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 661367008460 dimer interface [polypeptide binding]; other site 661367008461 putative CheW interface [polypeptide binding]; other site 661367008462 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367008463 putative binding surface; other site 661367008464 active site 661367008465 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367008466 putative binding surface; other site 661367008467 active site 661367008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008469 ATP binding site [chemical binding]; other site 661367008470 Mg2+ binding site [ion binding]; other site 661367008471 G-X-G motif; other site 661367008472 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 661367008473 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 661367008474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008475 active site 661367008476 phosphorylation site [posttranslational modification] 661367008477 intermolecular recognition site; other site 661367008478 dimerization interface [polypeptide binding]; other site 661367008479 CheB methylesterase; Region: CheB_methylest; pfam01339 661367008480 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008482 active site 661367008483 phosphorylation site [posttranslational modification] 661367008484 intermolecular recognition site; other site 661367008485 dimerization interface [polypeptide binding]; other site 661367008486 cyclase homology domain; Region: CHD; cd07302 661367008487 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367008488 nucleotidyl binding site; other site 661367008489 metal binding site [ion binding]; metal-binding site 661367008490 dimer interface [polypeptide binding]; other site 661367008491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367008492 TPR motif; other site 661367008493 binding surface 661367008494 Tetratricopeptide repeat; Region: TPR_16; pfam13432 661367008495 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 661367008496 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 661367008497 oligomer interface [polypeptide binding]; other site 661367008498 active site 661367008499 metal binding site [ion binding]; metal-binding site 661367008500 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 661367008501 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 661367008502 Ligand binding site; other site 661367008503 oligomer interface; other site 661367008504 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 661367008505 catalytic core [active] 661367008506 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 661367008507 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 661367008508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367008509 Coenzyme A binding pocket [chemical binding]; other site 661367008510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367008511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367008512 Coenzyme A binding pocket [chemical binding]; other site 661367008513 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367008514 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367008515 dimer interface [polypeptide binding]; other site 661367008516 active site 661367008517 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 661367008518 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 661367008519 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 661367008520 trimer interface [polypeptide binding]; other site 661367008521 active site 661367008522 UDP-GlcNAc binding site [chemical binding]; other site 661367008523 lipid binding site [chemical binding]; lipid-binding site 661367008524 DNA polymerase I; Provisional; Region: PRK05755 661367008525 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 661367008526 active site 661367008527 metal binding site 1 [ion binding]; metal-binding site 661367008528 putative 5' ssDNA interaction site; other site 661367008529 metal binding site 3; metal-binding site 661367008530 metal binding site 2 [ion binding]; metal-binding site 661367008531 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 661367008532 putative DNA binding site [nucleotide binding]; other site 661367008533 putative metal binding site [ion binding]; other site 661367008534 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 661367008535 active site 661367008536 catalytic site [active] 661367008537 substrate binding site [chemical binding]; other site 661367008538 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 661367008539 active site 661367008540 DNA binding site [nucleotide binding] 661367008541 catalytic site [active] 661367008542 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008544 active site 661367008545 phosphorylation site [posttranslational modification] 661367008546 intermolecular recognition site; other site 661367008547 dimerization interface [polypeptide binding]; other site 661367008548 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008550 active site 661367008551 phosphorylation site [posttranslational modification] 661367008552 intermolecular recognition site; other site 661367008553 dimerization interface [polypeptide binding]; other site 661367008554 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 661367008555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367008556 putative active site [active] 661367008557 heme pocket [chemical binding]; other site 661367008558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367008559 dimer interface [polypeptide binding]; other site 661367008560 phosphorylation site [posttranslational modification] 661367008561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008562 ATP binding site [chemical binding]; other site 661367008563 Mg2+ binding site [ion binding]; other site 661367008564 G-X-G motif; other site 661367008565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 661367008566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008567 active site 661367008568 phosphorylation site [posttranslational modification] 661367008569 intermolecular recognition site; other site 661367008570 5' nucleotidase family; Region: 5_nucleotid; cl17687 661367008571 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 661367008572 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 661367008573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 661367008574 active site 661367008575 dimer interface [polypeptide binding]; other site 661367008576 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 661367008577 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 661367008578 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 661367008579 ribonuclease R; Region: RNase_R; TIGR02063 661367008580 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 661367008581 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367008582 RNB domain; Region: RNB; pfam00773 661367008583 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 661367008584 RNA binding site [nucleotide binding]; other site 661367008585 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008587 substrate binding pocket [chemical binding]; other site 661367008588 membrane-bound complex binding site; other site 661367008589 hinge residues; other site 661367008590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008592 substrate binding pocket [chemical binding]; other site 661367008593 membrane-bound complex binding site; other site 661367008594 hinge residues; other site 661367008595 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 661367008596 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 661367008597 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 661367008598 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 661367008599 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 661367008600 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367008601 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 661367008602 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 661367008603 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 661367008604 proline aminopeptidase P II; Provisional; Region: PRK10879 661367008605 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 661367008606 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 661367008607 active site 661367008608 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 661367008609 Cell division protein ZapA; Region: ZapA; cl01146 661367008610 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 661367008611 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 661367008612 active site 661367008613 FMN binding site [chemical binding]; other site 661367008614 substrate binding site [chemical binding]; other site 661367008615 3Fe-4S cluster binding site [ion binding]; other site 661367008616 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 661367008617 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 661367008618 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008619 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008620 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 661367008621 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 661367008622 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367008623 substrate binding pocket [chemical binding]; other site 661367008624 chain length determination region; other site 661367008625 substrate-Mg2+ binding site; other site 661367008626 catalytic residues [active] 661367008627 aspartate-rich region 1; other site 661367008628 active site lid residues [active] 661367008629 aspartate-rich region 2; other site 661367008630 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 661367008631 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 661367008632 putative catalytic residue [active] 661367008633 excinuclease ABC subunit B; Provisional; Region: PRK05298 661367008634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367008635 ATP binding site [chemical binding]; other site 661367008636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367008637 nucleotide binding region [chemical binding]; other site 661367008638 ATP-binding site [chemical binding]; other site 661367008639 Ultra-violet resistance protein B; Region: UvrB; pfam12344 661367008640 UvrB/uvrC motif; Region: UVR; pfam02151 661367008641 aspartate aminotransferase; Provisional; Region: PRK05764 661367008642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367008643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008644 homodimer interface [polypeptide binding]; other site 661367008645 catalytic residue [active] 661367008646 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 661367008647 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 661367008648 nudix motif; other site 661367008649 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008650 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008651 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008652 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008653 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008654 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008655 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008656 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008657 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008658 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008659 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008660 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008661 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008662 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008663 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008664 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 661367008665 DNA binding site [nucleotide binding] 661367008666 active site 661367008667 Int/Topo IB signature motif; other site 661367008668 catalytic residues [active] 661367008669 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 661367008670 active site 661367008671 homodimer interface [polypeptide binding]; other site 661367008672 SAM binding site [chemical binding]; other site 661367008673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367008674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008675 putative substrate translocation pore; other site 661367008676 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367008677 active site 661367008678 iron coordination sites [ion binding]; other site 661367008679 substrate binding pocket [chemical binding]; other site 661367008680 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 661367008681 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 661367008682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 661367008683 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 661367008684 putative transporter; Provisional; Region: PRK10054 661367008685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008686 putative substrate translocation pore; other site 661367008687 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 661367008688 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 661367008689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367008690 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367008691 active site 661367008692 DNA binding site [nucleotide binding] 661367008693 Int/Topo IB signature motif; other site 661367008694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367008695 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 661367008696 Predicted acetyltransferase [General function prediction only]; Region: COG5628 661367008697 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 661367008698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367008699 S-adenosylmethionine binding site [chemical binding]; other site 661367008700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008702 substrate binding pocket [chemical binding]; other site 661367008703 membrane-bound complex binding site; other site 661367008704 hinge residues; other site 661367008705 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 661367008706 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 661367008707 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 661367008708 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 661367008709 active site 661367008710 catalytic site [active] 661367008711 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367008712 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 661367008713 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367008714 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 661367008715 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367008716 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 661367008717 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 661367008718 C-terminal domain interface [polypeptide binding]; other site 661367008719 GSH binding site (G-site) [chemical binding]; other site 661367008720 dimer interface [polypeptide binding]; other site 661367008721 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 661367008722 N-terminal domain interface [polypeptide binding]; other site 661367008723 dimer interface [polypeptide binding]; other site 661367008724 substrate binding pocket (H-site) [chemical binding]; other site 661367008725 ATP-dependent helicase HepA; Validated; Region: PRK04914 661367008726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367008727 ATP binding site [chemical binding]; other site 661367008728 putative Mg++ binding site [ion binding]; other site 661367008729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367008730 nucleotide binding region [chemical binding]; other site 661367008731 ATP-binding site [chemical binding]; other site 661367008732 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 661367008733 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 661367008734 iron-sulfur cluster [ion binding]; other site 661367008735 [2Fe-2S] cluster binding site [ion binding]; other site 661367008736 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 661367008737 putative deacylase active site [active] 661367008738 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 661367008739 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 661367008740 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 661367008741 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367008742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008743 metal binding site [ion binding]; metal-binding site 661367008744 active site 661367008745 I-site; other site 661367008746 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367008747 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 661367008748 active site 661367008749 NTP binding site [chemical binding]; other site 661367008750 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367008751 nucleic acid binding site [nucleotide binding]; other site 661367008752 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367008753 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367008754 ligand binding site [chemical binding]; other site 661367008755 flexible hinge region; other site 661367008756 CAAX protease self-immunity; Region: Abi; pfam02517 661367008757 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 661367008758 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 661367008759 putative active site [active] 661367008760 Zn binding site [ion binding]; other site 661367008761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367008762 S-adenosylmethionine binding site [chemical binding]; other site 661367008763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367008764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 661367008765 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 661367008766 substrate binding pocket [chemical binding]; other site 661367008767 dimerization interface [polypeptide binding]; other site 661367008768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008769 TIGR01777 family protein; Region: yfcH 661367008770 NAD(P) binding site [chemical binding]; other site 661367008771 active site 661367008772 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 661367008773 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 661367008774 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 661367008775 Rossmann-like domain; Region: Rossmann-like; pfam10727 661367008776 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 661367008777 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 661367008778 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367008779 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367008780 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367008781 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 661367008782 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 661367008783 CAP-like domain; other site 661367008784 active site 661367008785 primary dimer interface [polypeptide binding]; other site 661367008786 CHASE3 domain; Region: CHASE3; pfam05227 661367008787 PAS fold; Region: PAS_4; pfam08448 661367008788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 661367008789 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 661367008790 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367008791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008792 metal binding site [ion binding]; metal-binding site 661367008793 active site 661367008794 I-site; other site 661367008795 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 661367008796 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 661367008797 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367008798 HlyD family secretion protein; Region: HlyD_3; pfam13437 661367008799 Outer membrane efflux protein; Region: OEP; pfam02321 661367008800 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367008801 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 661367008802 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 661367008803 gamma subunit interface [polypeptide binding]; other site 661367008804 epsilon subunit interface [polypeptide binding]; other site 661367008805 LBP interface [polypeptide binding]; other site 661367008806 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 661367008807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 661367008808 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 661367008809 alpha subunit interaction interface [polypeptide binding]; other site 661367008810 Walker A motif; other site 661367008811 ATP binding site [chemical binding]; other site 661367008812 Walker B motif; other site 661367008813 inhibitor binding site; inhibition site 661367008814 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 661367008815 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 661367008816 core domain interface [polypeptide binding]; other site 661367008817 delta subunit interface [polypeptide binding]; other site 661367008818 epsilon subunit interface [polypeptide binding]; other site 661367008819 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 661367008820 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 661367008821 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 661367008822 beta subunit interaction interface [polypeptide binding]; other site 661367008823 Walker A motif; other site 661367008824 ATP binding site [chemical binding]; other site 661367008825 Walker B motif; other site 661367008826 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 661367008827 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 661367008828 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 661367008829 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 661367008830 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 661367008831 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 661367008832 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 661367008833 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 661367008834 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 661367008835 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 661367008836 dimer interface [polypeptide binding]; other site 661367008837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367008838 active site 661367008839 metal binding site [ion binding]; metal-binding site 661367008840 glutathione binding site [chemical binding]; other site 661367008841 Uncharacterized conserved protein [Function unknown]; Region: COG5361 661367008842 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 661367008843 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 661367008844 outer membrane lipoprotein; Provisional; Region: PRK11023 661367008845 BON domain; Region: BON; pfam04972 661367008846 BON domain; Region: BON; pfam04972 661367008847 BON domain; Region: BON; pfam04972 661367008848 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 661367008849 dimer interface [polypeptide binding]; other site 661367008850 active site 661367008851 hypothetical protein; Reviewed; Region: PRK12497 661367008852 LppC putative lipoprotein; Region: LppC; pfam04348 661367008853 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 661367008854 putative ligand binding site [chemical binding]; other site 661367008855 Predicted methyltransferases [General function prediction only]; Region: COG0313 661367008856 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 661367008857 putative SAM binding site [chemical binding]; other site 661367008858 putative homodimer interface [polypeptide binding]; other site 661367008859 Cytochrome P450; Region: p450; cl12078 661367008860 Trehalase; Region: Trehalase; cl17346 661367008861 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 661367008862 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 661367008863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367008864 dimer interface [polypeptide binding]; other site 661367008865 phosphorylation site [posttranslational modification] 661367008866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008867 ATP binding site [chemical binding]; other site 661367008868 Mg2+ binding site [ion binding]; other site 661367008869 G-X-G motif; other site 661367008870 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008872 active site 661367008873 phosphorylation site [posttranslational modification] 661367008874 intermolecular recognition site; other site 661367008875 dimerization interface [polypeptide binding]; other site 661367008876 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 661367008877 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 661367008878 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 661367008879 acyl-activating enzyme (AAE) consensus motif; other site 661367008880 AMP binding site [chemical binding]; other site 661367008881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367008882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367008883 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367008884 active site 661367008885 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367008886 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 661367008887 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 661367008888 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 661367008889 putative NADP binding site [chemical binding]; other site 661367008890 active site 661367008891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 661367008892 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 661367008893 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 661367008894 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 661367008895 trmE is a tRNA modification GTPase; Region: trmE; cd04164 661367008896 G1 box; other site 661367008897 GTP/Mg2+ binding site [chemical binding]; other site 661367008898 Switch I region; other site 661367008899 G2 box; other site 661367008900 Switch II region; other site 661367008901 G3 box; other site 661367008902 G4 box; other site 661367008903 G5 box; other site 661367008904 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 661367008905 membrane protein insertase; Provisional; Region: PRK01318 661367008906 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 661367008907 hypothetical protein; Provisional; Region: PRK14380 661367008908 Ribonuclease P; Region: Ribonuclease_P; cl00457 661367008909 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 661367008910 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 661367008911 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367008912 P-loop; other site 661367008913 Magnesium ion binding site [ion binding]; other site 661367008914 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367008915 Magnesium ion binding site [ion binding]; other site 661367008916 ParB-like nuclease domain; Region: ParBc; pfam02195 661367008917 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 661367008918 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 661367008919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008921 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 661367008922 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 661367008923 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 661367008924 ATP binding site [chemical binding]; other site 661367008925 substrate interface [chemical binding]; other site 661367008926 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367008927 active site residue [active] 661367008928 Uncharacterized conserved protein [Function unknown]; Region: COG1944 661367008929 YcaO-like family; Region: YcaO; pfam02624 661367008930 TfuA-like protein; Region: TfuA; pfam07812 661367008931 TraA; Region: TraA; cl11503 661367008932 TraL protein; Region: TraL; cl06278 661367008933 TraE protein; Region: TraE; cl05060 661367008934 TraK protein; Region: TraK; pfam06586 661367008935 type-F conjugative transfer system secretin TraK; Region: TraK_Ftype; TIGR02756 661367008936 YebO-like protein; Region: YebO; pfam13974 661367008937 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 661367008938 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 661367008939 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 661367008940 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 661367008941 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515 661367008942 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 661367008943 TraU protein; Region: TraU; cl06067 661367008944 type-F conjugative transfer system pilin assembly protein TrbC; Region: TrbC_Ftype; TIGR02742 661367008945 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 661367008946 type-F conjugative transfer system pilin assembly protein TraF; Region: TraF; TIGR02739 661367008947 F plasmid transfer operon protein; Region: TraF; pfam13728 661367008948 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB; Region: TrbB; TIGR02738 661367008949 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 661367008950 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 661367008951 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 661367008952 F sex factor protein N terminal; Region: TraD_N; pfam12615 661367008953 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 661367008954 Walker A motif; other site 661367008955 ATP binding site [chemical binding]; other site 661367008956 Walker B motif; other site 661367008957 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 661367008958 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 661367008959 AAA domain; Region: AAA_30; pfam13604 661367008960 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 661367008961 active site 661367008962 metal binding site [ion binding]; metal-binding site 661367008963 interdomain interaction site; other site 661367008964 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 661367008965 Domain of unknown function (DUF932); Region: DUF932; cl12129 661367008966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367008967 RNA binding surface [nucleotide binding]; other site 661367008968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 661367008969 non-specific DNA binding site [nucleotide binding]; other site 661367008970 salt bridge; other site 661367008971 sequence-specific DNA binding site [nucleotide binding]; other site 661367008972 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 661367008973 multiple promoter invertase; Provisional; Region: mpi; PRK13413 661367008974 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 661367008975 catalytic residues [active] 661367008976 catalytic nucleophile [active] 661367008977 Presynaptic Site I dimer interface [polypeptide binding]; other site 661367008978 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 661367008979 Synaptic Flat tetramer interface [polypeptide binding]; other site 661367008980 Synaptic Site I dimer interface [polypeptide binding]; other site 661367008981 DNA binding site [nucleotide binding] 661367008982 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 661367008983 DNA-binding interface [nucleotide binding]; DNA binding site 661367008984 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367008985 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367008986 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 661367008987 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367008988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367008989 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367008990 Soluble P-type ATPase [General function prediction only]; Region: COG4087 661367008991 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367008992 universal stress protein UspE; Provisional; Region: PRK11175 661367008993 Universal stress protein family; Region: Usp; pfam00582 661367008994 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367008995 Ligand Binding Site [chemical binding]; other site 661367008996 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 661367008997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008998 NAD(P) binding site [chemical binding]; other site 661367008999 active site 661367009000 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 661367009001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367009002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367009003 substrate binding pocket [chemical binding]; other site 661367009004 membrane-bound complex binding site; other site 661367009005 hinge residues; other site 661367009006 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 661367009007 equals pllo0049b; putative transposase (partial) 661367009008 equals pllo0049a; putative transposase (partial) 661367009009 equals pllo0050; putative transposase (partial) 661367009010 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367009011 IHF dimer interface [polypeptide binding]; other site 661367009012 IHF - DNA interface [nucleotide binding]; other site 661367009013 equals pllo0052; putative single-stranded DNA-binding protein 661367009014 equals pllo0053; putative exonuclease (C-terminal part) 661367009015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 661367009016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 661367009017 PAS domain S-box; Region: sensory_box; TIGR00229 661367009018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367009019 putative active site [active] 661367009020 heme pocket [chemical binding]; other site 661367009021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 661367009022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367009023 metal binding site [ion binding]; metal-binding site 661367009024 active site 661367009025 I-site; other site 661367009026 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367009027 equals pllo0057; putative transposase (N-terminal part) 661367009028 equals pllo0058; putative transposase (C-terminal part) 661367009029 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 661367009030 dimer interface [polypeptide binding]; other site 661367009031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367009032 metal binding site [ion binding]; metal-binding site 661367009033 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 661367009034 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 661367009035 active site 661367009036 catalytic site [active] 661367009037 substrate binding site [chemical binding]; other site 661367009038 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 661367009039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 661367009040 MarR family; Region: MarR_2; pfam12802 661367009041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367009042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367009043 Coenzyme A binding pocket [chemical binding]; other site 661367009044 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367009045 active site 661367009046 DNA polymerase IV; Validated; Region: PRK02406 661367009047 DNA binding site [nucleotide binding] 661367009048 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367009049 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367009050 active site 661367009051 DNA binding site [nucleotide binding] 661367009052 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367009053 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367009054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367009055 Catalytic site [active] 661367009056 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 661367009057 DNA-specific endonuclease I; Provisional; Region: PRK15137 661367009058 Endonuclease I; Region: Endonuclease_1; pfam04231 661367009059 equals pllo0069; hypothetical protein (truncated) 661367009060 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605