-- dump date   	20140619_130208
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
400673000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
400673000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
400673000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673000004	Walker A motif; other site
400673000005	ATP binding site [chemical binding]; other site
400673000006	Walker B motif; other site
400673000007	arginine finger; other site
400673000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
400673000009	DnaA box-binding interface [nucleotide binding]; other site
400673000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
400673000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
400673000012	putative DNA binding surface [nucleotide binding]; other site
400673000013	dimer interface [polypeptide binding]; other site
400673000014	beta-clamp/clamp loader binding surface; other site
400673000015	beta-clamp/translesion DNA polymerase binding surface; other site
400673000016	recombination protein F; Reviewed; Region: recF; PRK00064
400673000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673000018	Walker A/P-loop; other site
400673000019	ATP binding site [chemical binding]; other site
400673000020	Q-loop/lid; other site
400673000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673000022	ABC transporter signature motif; other site
400673000023	Walker B; other site
400673000024	D-loop; other site
400673000025	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
400673000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673000027	Mg2+ binding site [ion binding]; other site
400673000028	G-X-G motif; other site
400673000029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
400673000030	anchoring element; other site
400673000031	dimer interface [polypeptide binding]; other site
400673000032	ATP binding site [chemical binding]; other site
400673000033	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
400673000034	active site
400673000035	putative metal-binding site [ion binding]; other site
400673000036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
400673000037	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
400673000038	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
400673000039	arginine decarboxylase; Provisional; Region: PRK05354
400673000040	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
400673000041	dimer interface [polypeptide binding]; other site
400673000042	active site
400673000043	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
400673000044	catalytic residues [active]
400673000045	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
400673000046	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
400673000047	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
400673000048	putative active site; other site
400673000049	catalytic triad [active]
400673000050	putative dimer interface [polypeptide binding]; other site
400673000051	bacterial Hfq-like; Region: Hfq; cd01716
400673000052	hexamer interface [polypeptide binding]; other site
400673000053	Sm1 motif; other site
400673000054	RNA binding site [nucleotide binding]; other site
400673000055	Sm2 motif; other site
400673000056	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
400673000057	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
400673000058	HflX GTPase family; Region: HflX; cd01878
400673000059	G1 box; other site
400673000060	GTP/Mg2+ binding site [chemical binding]; other site
400673000061	Switch I region; other site
400673000062	G2 box; other site
400673000063	G3 box; other site
400673000064	Switch II region; other site
400673000065	G4 box; other site
400673000066	G5 box; other site
400673000067	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
400673000068	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
400673000069	catalytic residues [active]
400673000070	Pirin-related protein [General function prediction only]; Region: COG1741
400673000071	Pirin; Region: Pirin; pfam02678
400673000072	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
400673000073	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
400673000074	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
400673000075	active site
400673000076	nucleophile elbow; other site
400673000077	Patatin phospholipase; Region: DUF3734; pfam12536
400673000078	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
400673000079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673000080	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673000081	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
400673000082	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
400673000083	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
400673000084	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
400673000085	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
400673000086	active site
400673000087	Zn binding site [ion binding]; other site
400673000088	hypothetical protein; Provisional; Region: PRK05255
400673000089	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
400673000090	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
400673000091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673000092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673000093	Protein of unknown function (DUF962); Region: DUF962; cl01879
400673000094	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
400673000095	amino acid transporter; Region: 2A0306; TIGR00909
400673000096	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
400673000097	Phosphate transporter family; Region: PHO4; pfam01384
400673000098	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
400673000099	diiron binding motif [ion binding]; other site
400673000100	PAS domain; Region: PAS_9; pfam13426
400673000101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673000102	putative active site [active]
400673000103	heme pocket [chemical binding]; other site
400673000104	PAS domain S-box; Region: sensory_box; TIGR00229
400673000105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673000106	putative active site [active]
400673000107	heme pocket [chemical binding]; other site
400673000108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673000109	PAS domain; Region: PAS_9; pfam13426
400673000110	putative active site [active]
400673000111	heme pocket [chemical binding]; other site
400673000112	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000113	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000114	metal binding site [ion binding]; metal-binding site
400673000115	active site
400673000116	I-site; other site
400673000117	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673000118	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
400673000119	Peptidase family M28; Region: Peptidase_M28; pfam04389
400673000120	active site
400673000121	metal binding site [ion binding]; metal-binding site
400673000122	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
400673000123	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673000124	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673000125	substrate binding pocket [chemical binding]; other site
400673000126	membrane-bound complex binding site; other site
400673000127	hinge residues; other site
400673000128	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673000129	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673000130	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
400673000131	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
400673000132	active site
400673000133	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
400673000134	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
400673000135	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
400673000136	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
400673000137	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
400673000138	trimer interface [polypeptide binding]; other site
400673000139	active site
400673000140	substrate binding site [chemical binding]; other site
400673000141	CoA binding site [chemical binding]; other site
400673000142	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
400673000143	amino acid transporter; Region: 2A0306; TIGR00909
400673000144	Entericidin EcnA/B family; Region: Entericidin; cl02322
400673000145	Predicted membrane protein [Function unknown]; Region: COG2323
400673000146	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
400673000147	tetramer interface [polypeptide binding]; other site
400673000148	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
400673000149	active site
400673000150	Mg2+/Mn2+ binding site [ion binding]; other site
400673000151	Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981
400673000152	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673000153	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000154	LysR substrate binding domain; Region: LysR_substrate; pfam03466
400673000155	dimerization interface [polypeptide binding]; other site
400673000156	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
400673000157	Radial spokehead-like protein; Region: Radial_spoke; pfam04712
400673000158	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
400673000159	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
400673000160	DNA binding residues [nucleotide binding]
400673000161	dimer interface [polypeptide binding]; other site
400673000162	mercury binding site [ion binding]; other site
400673000163	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
400673000164	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
400673000165	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000166	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000167	metal binding site [ion binding]; metal-binding site
400673000168	active site
400673000169	I-site; other site
400673000170	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673000171	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
400673000172	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
400673000173	active site
400673000174	SAM binding site [chemical binding]; other site
400673000175	homodimer interface [polypeptide binding]; other site
400673000176	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673000177	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
400673000178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673000179	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
400673000180	Serine hydrolase; Region: Ser_hydrolase; cl17834
400673000181	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673000182	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
400673000183	EamA-like transporter family; Region: EamA; pfam00892
400673000184	EamA-like transporter family; Region: EamA; pfam00892
400673000185	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
400673000186	integrase; Provisional; Region: PRK09692
400673000187	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
400673000188	active site
400673000189	Int/Topo IB signature motif; other site
400673000190	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
400673000191	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673000192	non-specific DNA binding site [nucleotide binding]; other site
400673000193	salt bridge; other site
400673000194	sequence-specific DNA binding site [nucleotide binding]; other site
400673000195	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
400673000196	aspartate aminotransferase; Provisional; Region: PRK05764
400673000197	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
400673000198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673000199	homodimer interface [polypeptide binding]; other site
400673000200	catalytic residue [active]
400673000201	excinuclease ABC subunit B; Provisional; Region: PRK05298
400673000202	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673000203	ATP binding site [chemical binding]; other site
400673000204	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673000205	nucleotide binding region [chemical binding]; other site
400673000206	ATP-binding site [chemical binding]; other site
400673000207	Ultra-violet resistance protein B; Region: UvrB; pfam12344
400673000208	UvrB/uvrC motif; Region: UVR; pfam02151
400673000209	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000211	metal binding site [ion binding]; metal-binding site
400673000212	active site
400673000213	I-site; other site
400673000214	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673000215	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
400673000216	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
400673000217	active site
400673000218	FMN binding site [chemical binding]; other site
400673000219	substrate binding site [chemical binding]; other site
400673000220	3Fe-4S cluster binding site [ion binding]; other site
400673000221	Cell division protein ZapA; Region: ZapA; pfam05164
400673000222	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
400673000223	proline aminopeptidase P II; Provisional; Region: PRK10879
400673000224	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
400673000225	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
400673000226	active site
400673000227	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
400673000228	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
400673000229	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
400673000230	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
400673000231	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
400673000232	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
400673000233	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
400673000234	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
400673000235	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673000236	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673000237	substrate binding pocket [chemical binding]; other site
400673000238	membrane-bound complex binding site; other site
400673000239	hinge residues; other site
400673000240	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
400673000241	ribonuclease R; Region: RNase_R; TIGR02063
400673000242	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
400673000243	RNB domain; Region: RNB; pfam00773
400673000244	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
400673000245	RNA binding site [nucleotide binding]; other site
400673000246	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
400673000247	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
400673000248	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
400673000249	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
400673000250	tetramer (dimer of dimers) interface [polypeptide binding]; other site
400673000251	active site
400673000252	dimer interface [polypeptide binding]; other site
400673000253	5' nucleotidase family; Region: 5_nucleotid; cl17687
400673000254	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
400673000255	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
400673000256	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
400673000257	PhnA protein; Region: PhnA; pfam03831
400673000258	Response regulator receiver domain; Region: Response_reg; pfam00072
400673000259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673000260	active site
400673000261	phosphorylation site [posttranslational modification]
400673000262	intermolecular recognition site; other site
400673000263	DNA polymerase I; Provisional; Region: PRK05755
400673000264	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
400673000265	active site
400673000266	metal binding site 1 [ion binding]; metal-binding site
400673000267	putative 5' ssDNA interaction site; other site
400673000268	metal binding site 3; metal-binding site
400673000269	metal binding site 2 [ion binding]; metal-binding site
400673000270	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
400673000271	putative DNA binding site [nucleotide binding]; other site
400673000272	putative metal binding site [ion binding]; other site
400673000273	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
400673000274	active site
400673000275	catalytic site [active]
400673000276	substrate binding site [chemical binding]; other site
400673000277	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
400673000278	active site
400673000279	DNA binding site [nucleotide binding]
400673000280	catalytic site [active]
400673000281	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
400673000282	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
400673000283	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
400673000284	trimer interface [polypeptide binding]; other site
400673000285	active site
400673000286	UDP-GlcNAc binding site [chemical binding]; other site
400673000287	lipid binding site [chemical binding]; lipid-binding site
400673000288	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
400673000289	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
400673000290	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
400673000291	dimer interface [polypeptide binding]; other site
400673000292	active site
400673000293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673000294	Coenzyme A binding pocket [chemical binding]; other site
400673000295	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
400673000296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673000297	Coenzyme A binding pocket [chemical binding]; other site
400673000298	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
400673000299	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
400673000300	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
400673000301	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
400673000302	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
400673000303	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
400673000304	substrate binding pocket [chemical binding]; other site
400673000305	substrate-Mg2+ binding site; other site
400673000306	aspartate-rich region 1; other site
400673000307	aspartate-rich region 2; other site
400673000308	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673000309	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
400673000310	EAL domain; Region: EAL; pfam00563
400673000311	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
400673000312	tetramer interface [polypeptide binding]; other site
400673000313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673000314	catalytic residue [active]
400673000315	YCII-related domain; Region: YCII; cl00999
400673000316	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
400673000317	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
400673000318	tetramer interface [polypeptide binding]; other site
400673000319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673000320	catalytic residue [active]
400673000321	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
400673000322	lipoyl attachment site [posttranslational modification]; other site
400673000323	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
400673000324	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
400673000325	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
400673000326	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673000327	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
400673000328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673000329	dimer interface [polypeptide binding]; other site
400673000330	conserved gate region; other site
400673000331	putative PBP binding loops; other site
400673000332	ABC-ATPase subunit interface; other site
400673000333	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
400673000334	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
400673000335	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
400673000336	Walker A/P-loop; other site
400673000337	ATP binding site [chemical binding]; other site
400673000338	Q-loop/lid; other site
400673000339	ABC transporter signature motif; other site
400673000340	Walker B; other site
400673000341	D-loop; other site
400673000342	H-loop/switch region; other site
400673000343	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
400673000344	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
400673000345	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
400673000346	catalytic residues [active]
400673000347	hinge region; other site
400673000348	alpha helical domain; other site
400673000349	Cytochrome c553 [Energy production and conversion]; Region: COG2863
400673000350	Cytochrome c; Region: Cytochrom_C; cl11414
400673000351	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
400673000352	G1 box; other site
400673000353	GTP/Mg2+ binding site [chemical binding]; other site
400673000354	Switch I region; other site
400673000355	G2 box; other site
400673000356	G3 box; other site
400673000357	Switch II region; other site
400673000358	G4 box; other site
400673000359	G5 box; other site
400673000360	acetyl-CoA synthetase; Provisional; Region: PRK00174
400673000361	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
400673000362	active site
400673000363	CoA binding site [chemical binding]; other site
400673000364	acyl-activating enzyme (AAE) consensus motif; other site
400673000365	AMP binding site [chemical binding]; other site
400673000366	acetate binding site [chemical binding]; other site
400673000367	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
400673000368	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
400673000369	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
400673000370	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
400673000371	tetrameric interface [polypeptide binding]; other site
400673000372	NAD binding site [chemical binding]; other site
400673000373	catalytic residues [active]
400673000374	Dodecin; Region: Dodecin; cl01328
400673000375	dihydrodipicolinate reductase; Provisional; Region: PRK00048
400673000376	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
400673000377	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
400673000378	ProQ/FINO family; Region: ProQ; pfam04352
400673000379	putative RNA binding sites [nucleotide binding]; other site
400673000380	pyruvate kinase; Provisional; Region: PRK05826
400673000381	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
400673000382	domain interfaces; other site
400673000383	active site
400673000384	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
400673000385	Phosphoglycerate kinase; Region: PGK; pfam00162
400673000386	substrate binding site [chemical binding]; other site
400673000387	hinge regions; other site
400673000388	ADP binding site [chemical binding]; other site
400673000389	catalytic site [active]
400673000390	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
400673000391	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
400673000392	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
400673000393	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
400673000394	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
400673000395	TPP-binding site [chemical binding]; other site
400673000396	dimer interface [polypeptide binding]; other site
400673000397	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
400673000398	PYR/PP interface [polypeptide binding]; other site
400673000399	dimer interface [polypeptide binding]; other site
400673000400	TPP binding site [chemical binding]; other site
400673000401	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
400673000402	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
400673000403	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
400673000404	active site
400673000405	Zn binding site [ion binding]; other site
400673000406	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673000407	Sel1-like repeats; Region: SEL1; smart00671
400673000408	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673000409	sequence-specific DNA binding site [nucleotide binding]; other site
400673000410	salt bridge; other site
400673000411	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
400673000412	Catalytic site [active]
400673000413	Global regulator protein family; Region: CsrA; pfam02599
400673000414	conjugal transfer ATPase TrbB; Provisional; Region: PRK13894
400673000415	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
400673000416	ATP binding site [chemical binding]; other site
400673000417	Walker A motif; other site
400673000418	hexamer interface [polypeptide binding]; other site
400673000419	Walker B motif; other site
400673000420	TrbC/VIRB2 family; Region: TrbC; cl01583
400673000421	conjugal transfer protein TrbD; Provisional; Region: PRK13823
400673000422	conjugal transfer protein TrbE; Provisional; Region: PRK13891
400673000423	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
400673000424	conjugal transfer protein TrbF; Provisional; Region: PRK13887
400673000425	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
400673000426	VirB7 interaction site; other site
400673000427	conjugal transfer protein TrbH; Provisional; Region: PRK13883
400673000428	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
400673000429	conjugal transfer protein TrbI; Provisional; Region: PRK13881
400673000430	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
400673000431	conjugal transfer protein TrbJ; Provisional; Region: PRK13879
400673000432	P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783
400673000433	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
400673000434	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673000435	Walker A motif; other site
400673000436	ATP binding site [chemical binding]; other site
400673000437	Walker B motif; other site
400673000438	conjugal transfer peptidase TraF; Provisional; Region: PRK13884
400673000439	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
400673000440	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
400673000441	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
400673000442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
400673000443	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
400673000444	active site
400673000445	metal binding site [ion binding]; metal-binding site
400673000446	interdomain interaction site; other site
400673000447	Uncharacterized conserved protein [Function unknown]; Region: COG4933
400673000448	Phagosome trafficking protein DotA; Region: DotA; pfam11388
400673000449	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
400673000450	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
400673000451	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
400673000452	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
400673000453	P-loop; other site
400673000454	Transcriptional activator TraM; Region: Activator-TraM; pfam11657
400673000455	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
400673000456	nucleoside/Zn binding site; other site
400673000457	dimer interface [polypeptide binding]; other site
400673000458	catalytic motif [active]
400673000459	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
400673000460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673000461	sequence-specific DNA binding site [nucleotide binding]; other site
400673000462	salt bridge; other site
400673000463	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
400673000464	Catalytic site [active]
400673000465	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
400673000466	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
400673000467	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
400673000468	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
400673000469	Int/Topo IB signature motif; other site
400673000470	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
400673000471	Predicted transcriptional regulator [Transcription]; Region: COG5340
400673000472	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
400673000473	integrase; Provisional; Region: PRK09692
400673000474	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
400673000475	active site
400673000476	Int/Topo IB signature motif; other site
400673000477	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
400673000478	BRO family, N-terminal domain; Region: Bro-N; pfam02498
400673000479	Peptidase family M48; Region: Peptidase_M48; cl12018
400673000480	tellurium resistance terB-like protein; Region: terB_like; cd07177
400673000481	metal binding site [ion binding]; metal-binding site
400673000482	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
400673000483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
400673000484	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
400673000485	active site
400673000486	metal binding site [ion binding]; metal-binding site
400673000487	interdomain interaction site; other site
400673000488	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
400673000489	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
400673000490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673000491	non-specific DNA binding site [nucleotide binding]; other site
400673000492	salt bridge; other site
400673000493	sequence-specific DNA binding site [nucleotide binding]; other site
400673000494	Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653
400673000495	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
400673000496	Mrr N-terminal domain; Region: Mrr_N; pfam14338
400673000497	Restriction endonuclease; Region: Mrr_cat; pfam04471
400673000498	Transposase IS200 like; Region: Y1_Tnp; cl00848
400673000499	hypothetical protein; Provisional; Region: PRK10040
400673000500	Staphylococcal nuclease homologues; Region: SNc; smart00318
400673000501	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
400673000502	Catalytic site; other site
400673000503	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
400673000504	active site
400673000505	reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612
400673000506	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673000507	Coenzyme A binding pocket [chemical binding]; other site
400673000508	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
400673000509	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
400673000510	Walker A/P-loop; other site
400673000511	ATP binding site [chemical binding]; other site
400673000512	Q-loop/lid; other site
400673000513	ABC transporter signature motif; other site
400673000514	Walker B; other site
400673000515	D-loop; other site
400673000516	H-loop/switch region; other site
400673000517	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
400673000518	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
400673000519	FtsX-like permease family; Region: FtsX; pfam02687
400673000520	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673000521	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673000522	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673000523	PAS domain; Region: PAS_9; pfam13426
400673000524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673000525	putative active site [active]
400673000526	heme pocket [chemical binding]; other site
400673000527	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000528	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000529	metal binding site [ion binding]; metal-binding site
400673000530	active site
400673000531	I-site; other site
400673000532	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
400673000533	active site
400673000534	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
400673000535	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
400673000536	Uncharacterized conserved protein [Function unknown]; Region: COG0432
400673000537	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
400673000538	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
400673000539	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
400673000540	Protein of unknown function (DUF808); Region: DUF808; cl01002
400673000541	RF-1 domain; Region: RF-1; pfam00472
400673000542	Protein of unknown function (DUF330); Region: DUF330; pfam03886
400673000543	mce related protein; Region: MCE; pfam02470
400673000544	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
400673000545	Permease; Region: Permease; pfam02405
400673000546	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673000547	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000548	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
400673000549	dimerization interface [polypeptide binding]; other site
400673000550	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
400673000551	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
400673000552	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
400673000553	substrate binding pocket [chemical binding]; other site
400673000554	active site
400673000555	iron coordination sites [ion binding]; other site
400673000556	hypothetical protein; Provisional; Region: PRK07190
400673000557	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
400673000558	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
400673000559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673000560	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673000561	putative substrate translocation pore; other site
400673000562	hypothetical protein; Provisional; Region: PRK07206
400673000563	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
400673000564	Methyltransferase domain; Region: Methyltransf_31; pfam13847
400673000565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673000566	S-adenosylmethionine binding site [chemical binding]; other site
400673000567	M48 family peptidase; Provisional; Region: PRK03001
400673000568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
400673000569	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
400673000570	hypothetical protein; Provisional; Region: PRK09133
400673000571	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
400673000572	putative metal binding site [ion binding]; other site
400673000573	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
400673000574	CoA-transferase family III; Region: CoA_transf_3; pfam02515
400673000575	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
400673000576	dimer interface [polypeptide binding]; other site
400673000577	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
400673000578	active site
400673000579	heme binding site [chemical binding]; other site
400673000580	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
400673000581	Uncharacterized conserved protein [Function unknown]; Region: COG0393
400673000582	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
400673000583	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
400673000584	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
400673000585	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
400673000586	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
400673000587	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
400673000588	DAK2 domain; Region: Dak2; pfam02734
400673000589	EDD domain protein, DegV family; Region: DegV; TIGR00762
400673000590	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
400673000591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
400673000592	classical (c) SDRs; Region: SDR_c; cd05233
400673000593	NAD(P) binding site [chemical binding]; other site
400673000594	active site
400673000595	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
400673000596	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
400673000597	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
400673000598	Catalytic domain of Protein Kinases; Region: PKc; cd00180
400673000599	active site
400673000600	ATP binding site [chemical binding]; other site
400673000601	substrate binding site [chemical binding]; other site
400673000602	activation loop (A-loop); other site
400673000603	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
400673000604	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
400673000605	DNA photolyase; Region: DNA_photolyase; pfam00875
400673000606	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
400673000607	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
400673000608	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673000609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000610	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
400673000611	putative dimerization interface [polypeptide binding]; other site
400673000612	Domain of unknown function (DUF329); Region: DUF329; pfam03884
400673000613	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
400673000614	ATP-grasp domain; Region: ATP-grasp; pfam02222
400673000615	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
400673000616	Nitrogen regulatory protein P-II; Region: P-II; cl00412
400673000617	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
400673000618	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
400673000619	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
400673000620	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673000621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000622	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
400673000623	dimerization interface [polypeptide binding]; other site
400673000624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673000625	ATP binding site [chemical binding]; other site
400673000626	Q-loop/lid; other site
400673000627	ABC transporter signature motif; other site
400673000628	Walker B; other site
400673000629	D-loop; other site
400673000630	H-loop/switch region; other site
400673000631	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673000632	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673000633	Outer membrane efflux protein; Region: OEP; pfam02321
400673000634	Outer membrane efflux protein; Region: OEP; pfam02321
400673000635	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
400673000636	heme binding pocket [chemical binding]; other site
400673000637	heme ligand [chemical binding]; other site
400673000638	CHASE3 domain; Region: CHASE3; pfam05227
400673000639	PAS domain; Region: PAS_9; pfam13426
400673000640	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
400673000641	GAF domain; Region: GAF; cl17456
400673000642	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000643	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000644	metal binding site [ion binding]; metal-binding site
400673000645	active site
400673000646	I-site; other site
400673000647	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
400673000648	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673000649	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673000650	motif II; other site
400673000651	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
400673000652	metal binding site 2 [ion binding]; metal-binding site
400673000653	putative DNA binding helix; other site
400673000654	metal binding site 1 [ion binding]; metal-binding site
400673000655	dimer interface [polypeptide binding]; other site
400673000656	structural Zn2+ binding site [ion binding]; other site
400673000657	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
400673000658	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
400673000659	PYR/PP interface [polypeptide binding]; other site
400673000660	dimer interface [polypeptide binding]; other site
400673000661	TPP binding site [chemical binding]; other site
400673000662	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
400673000663	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
400673000664	TPP-binding site [chemical binding]; other site
400673000665	dimer interface [polypeptide binding]; other site
400673000666	Dot/Icm substrate protein; Region: SidE; pfam12252
400673000667	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
400673000668	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
400673000669	TAP-like protein; Region: Abhydrolase_4; pfam08386
400673000670	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
400673000671	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
400673000672	tetramerization interface [polypeptide binding]; other site
400673000673	NAD(P) binding site [chemical binding]; other site
400673000674	catalytic residues [active]
400673000675	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
400673000676	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
400673000677	inhibitor-cofactor binding pocket; inhibition site
400673000678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673000679	catalytic residue [active]
400673000680	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
400673000681	glutaminase A; Region: Gln_ase; TIGR03814
400673000682	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
400673000683	putative NAD(P) binding site [chemical binding]; other site
400673000684	homodimer interface [polypeptide binding]; other site
400673000685	mercuric reductase; Validated; Region: PRK06370
400673000686	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673000687	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
400673000688	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
400673000689	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
400673000690	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
400673000691	ArsC family; Region: ArsC; pfam03960
400673000692	catalytic residues [active]
400673000693	Fatty acid desaturase; Region: FA_desaturase; pfam00487
400673000694	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
400673000695	Di-iron ligands [ion binding]; other site
400673000696	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673000697	helicase 45; Provisional; Region: PTZ00424
400673000698	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
400673000699	ATP binding site [chemical binding]; other site
400673000700	Mg++ binding site [ion binding]; other site
400673000701	motif III; other site
400673000702	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673000703	nucleotide binding region [chemical binding]; other site
400673000704	ATP-binding site [chemical binding]; other site
400673000705	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
400673000706	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
400673000707	hypothetical protein; Provisional; Region: PRK11212
400673000708	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
400673000709	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
400673000710	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
400673000711	HlyD family secretion protein; Region: HlyD; pfam00529
400673000712	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673000713	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673000714	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
400673000715	Fe-S cluster binding site [ion binding]; other site
400673000716	active site
400673000717	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
400673000718	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
400673000719	amidase catalytic site [active]
400673000720	Zn binding residues [ion binding]; other site
400673000721	substrate binding site [chemical binding]; other site
400673000722	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
400673000723	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
400673000724	Multicopper oxidase; Region: Cu-oxidase; pfam00394
400673000725	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
400673000726	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
400673000727	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
400673000728	oligomer interface [polypeptide binding]; other site
400673000729	metal binding site [ion binding]; metal-binding site
400673000730	metal binding site [ion binding]; metal-binding site
400673000731	putative Cl binding site [ion binding]; other site
400673000732	aspartate ring; other site
400673000733	hydrophobic gate; other site
400673000734	basic sphincter; other site
400673000735	periplasmic entrance; other site
400673000736	HD domain; Region: HD_3; pfam13023
400673000737	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
400673000738	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
400673000739	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
400673000740	active site
400673000741	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
400673000742	Isochorismatase family; Region: Isochorismatase; pfam00857
400673000743	catalytic triad [active]
400673000744	metal binding site [ion binding]; metal-binding site
400673000745	conserved cis-peptide bond; other site
400673000746	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
400673000747	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
400673000748	metal binding site [ion binding]; metal-binding site
400673000749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673000750	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
400673000751	putative substrate translocation pore; other site
400673000752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673000753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000754	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
400673000755	putative effector binding pocket; other site
400673000756	dimerization interface [polypeptide binding]; other site
400673000757	Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485
400673000758	Ras interaction site [polypeptide binding]; other site
400673000759	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
400673000760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673000761	active site
400673000762	phosphorylation site [posttranslational modification]
400673000763	intermolecular recognition site; other site
400673000764	dimerization interface [polypeptide binding]; other site
400673000765	PAS domain; Region: PAS; smart00091
400673000766	PAS fold; Region: PAS_7; pfam12860
400673000767	putative active site [active]
400673000768	heme pocket [chemical binding]; other site
400673000769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673000770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673000771	metal binding site [ion binding]; metal-binding site
400673000772	active site
400673000773	I-site; other site
400673000774	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673000775	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
400673000776	PAS fold; Region: PAS_3; pfam08447
400673000777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673000778	ATP binding site [chemical binding]; other site
400673000779	Mg2+ binding site [ion binding]; other site
400673000780	G-X-G motif; other site
400673000781	FIST N domain; Region: FIST; pfam08495
400673000782	Uncharacterized conserved protein [Function unknown]; Region: COG3287
400673000783	FIST C domain; Region: FIST_C; pfam10442
400673000784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673000785	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
400673000786	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
400673000787	dimerization interface [polypeptide binding]; other site
400673000788	amino acid transporter; Region: 2A0306; TIGR00909
400673000789	hypothetical protein; Provisional; Region: PRK08317
400673000790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673000791	S-adenosylmethionine binding site [chemical binding]; other site
400673000792	formate dehydrogenase; Provisional; Region: PRK07574
400673000793	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
400673000794	dimerization interface [polypeptide binding]; other site
400673000795	ligand binding site [chemical binding]; other site
400673000796	NAD binding site [chemical binding]; other site
400673000797	catalytic site [active]
400673000798	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
400673000799	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
400673000800	putative NAD(P) binding site [chemical binding]; other site
400673000801	homodimer interface [polypeptide binding]; other site
400673000802	homotetramer interface [polypeptide binding]; other site
400673000803	active site
400673000804	elongation factor P; Validated; Region: PRK00529
400673000805	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
400673000806	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
400673000807	RNA binding site [nucleotide binding]; other site
400673000808	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
400673000809	RNA binding site [nucleotide binding]; other site
400673000810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
400673000811	Radical SAM superfamily; Region: Radical_SAM; pfam04055
400673000812	FeS/SAM binding site; other site
400673000813	polyphosphate kinase; Provisional; Region: PRK05443
400673000814	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
400673000815	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
400673000816	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
400673000817	putative active site [active]
400673000818	catalytic site [active]
400673000819	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
400673000820	putative domain interface [polypeptide binding]; other site
400673000821	putative active site [active]
400673000822	catalytic site [active]
400673000823	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
400673000824	nucleophile elbow; other site
400673000825	Chromate transporter; Region: Chromate_transp; pfam02417
400673000826	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
400673000827	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
400673000828	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
400673000829	active site
400673000830	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
400673000831	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
400673000832	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
400673000833	Substrate binding site; other site
400673000834	metal-binding site
400673000835	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
400673000836	Phosphotransferase enzyme family; Region: APH; pfam01636
400673000837	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
400673000838	OstA-like protein; Region: OstA; cl00844
400673000839	Organic solvent tolerance protein; Region: OstA_C; pfam04453
400673000840	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
400673000841	SurA N-terminal domain; Region: SurA_N; pfam09312
400673000842	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
400673000843	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
400673000844	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
400673000845	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
400673000846	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
400673000847	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
400673000848	folate binding site [chemical binding]; other site
400673000849	NADP+ binding site [chemical binding]; other site
400673000850	Repeats found in Drosophila proteins; Region: DM9; smart00696
400673000851	Protein of unknown function (DUF3421); Region: DUF3421; pfam11901
400673000852	Repeats found in Drosophila proteins; Region: DM9; smart00696
400673000853	elongation factor Tu; Reviewed; Region: PRK00049
400673000854	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
400673000855	G1 box; other site
400673000856	GEF interaction site [polypeptide binding]; other site
400673000857	GTP/Mg2+ binding site [chemical binding]; other site
400673000858	Switch I region; other site
400673000859	G2 box; other site
400673000860	G3 box; other site
400673000861	Switch II region; other site
400673000862	G4 box; other site
400673000863	G5 box; other site
400673000864	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
400673000865	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
400673000866	Antibiotic Binding Site [chemical binding]; other site
400673000867	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
400673000868	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
400673000869	putative homodimer interface [polypeptide binding]; other site
400673000870	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
400673000871	heterodimer interface [polypeptide binding]; other site
400673000872	homodimer interface [polypeptide binding]; other site
400673000873	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
400673000874	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
400673000875	23S rRNA interface [nucleotide binding]; other site
400673000876	L7/L12 interface [polypeptide binding]; other site
400673000877	putative thiostrepton binding site; other site
400673000878	L25 interface [polypeptide binding]; other site
400673000879	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
400673000880	mRNA/rRNA interface [nucleotide binding]; other site
400673000881	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
400673000882	23S rRNA interface [nucleotide binding]; other site
400673000883	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
400673000884	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
400673000885	peripheral dimer interface [polypeptide binding]; other site
400673000886	core dimer interface [polypeptide binding]; other site
400673000887	L10 interface [polypeptide binding]; other site
400673000888	L11 interface [polypeptide binding]; other site
400673000889	putative EF-Tu interaction site [polypeptide binding]; other site
400673000890	putative EF-G interaction site [polypeptide binding]; other site
400673000891	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
400673000892	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
400673000893	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
400673000894	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
400673000895	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
400673000896	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
400673000897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
400673000898	RPB3 interaction site [polypeptide binding]; other site
400673000899	RPB1 interaction site [polypeptide binding]; other site
400673000900	RPB11 interaction site [polypeptide binding]; other site
400673000901	RPB10 interaction site [polypeptide binding]; other site
400673000902	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
400673000903	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
400673000904	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
400673000905	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
400673000906	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
400673000907	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
400673000908	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
400673000909	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
400673000910	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
400673000911	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
400673000912	DNA binding site [nucleotide binding]
400673000913	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
400673000914	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
400673000915	S17 interaction site [polypeptide binding]; other site
400673000916	S8 interaction site; other site
400673000917	16S rRNA interaction site [nucleotide binding]; other site
400673000918	streptomycin interaction site [chemical binding]; other site
400673000919	23S rRNA interaction site [nucleotide binding]; other site
400673000920	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
400673000921	30S ribosomal protein S7; Validated; Region: PRK05302
400673000922	elongation factor G; Reviewed; Region: PRK00007
400673000923	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
400673000924	G1 box; other site
400673000925	putative GEF interaction site [polypeptide binding]; other site
400673000926	GTP/Mg2+ binding site [chemical binding]; other site
400673000927	Switch I region; other site
400673000928	G2 box; other site
400673000929	G3 box; other site
400673000930	Switch II region; other site
400673000931	G4 box; other site
400673000932	G5 box; other site
400673000933	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
400673000934	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
400673000935	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
400673000936	elongation factor Tu; Reviewed; Region: PRK00049
400673000937	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
400673000938	G1 box; other site
400673000939	GEF interaction site [polypeptide binding]; other site
400673000940	GTP/Mg2+ binding site [chemical binding]; other site
400673000941	Switch I region; other site
400673000942	G2 box; other site
400673000943	G3 box; other site
400673000944	Switch II region; other site
400673000945	G4 box; other site
400673000946	G5 box; other site
400673000947	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
400673000948	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
400673000949	Antibiotic Binding Site [chemical binding]; other site
400673000950	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
400673000951	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
400673000952	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
400673000953	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
400673000954	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
400673000955	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
400673000956	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
400673000957	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
400673000958	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
400673000959	putative translocon binding site; other site
400673000960	protein-rRNA interface [nucleotide binding]; other site
400673000961	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
400673000962	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
400673000963	G-X-X-G motif; other site
400673000964	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
400673000965	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
400673000966	23S rRNA interface [nucleotide binding]; other site
400673000967	5S rRNA interface [nucleotide binding]; other site
400673000968	putative antibiotic binding site [chemical binding]; other site
400673000969	L25 interface [polypeptide binding]; other site
400673000970	L27 interface [polypeptide binding]; other site
400673000971	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
400673000972	putative translocon interaction site; other site
400673000973	23S rRNA interface [nucleotide binding]; other site
400673000974	signal recognition particle (SRP54) interaction site; other site
400673000975	L23 interface [polypeptide binding]; other site
400673000976	trigger factor interaction site; other site
400673000977	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
400673000978	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
400673000979	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
400673000980	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
400673000981	RNA binding site [nucleotide binding]; other site
400673000982	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
400673000983	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
400673000984	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
400673000985	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK06911
400673000986	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
400673000987	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
400673000988	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
400673000989	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
400673000990	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
400673000991	23S rRNA interface [nucleotide binding]; other site
400673000992	L21e interface [polypeptide binding]; other site
400673000993	5S rRNA interface [nucleotide binding]; other site
400673000994	L27 interface [polypeptide binding]; other site
400673000995	L5 interface [polypeptide binding]; other site
400673000996	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
400673000997	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
400673000998	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
400673000999	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
400673001000	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
400673001001	SecY translocase; Region: SecY; pfam00344
400673001002	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
400673001003	30S ribosomal protein S13; Region: bact_S13; TIGR03631
400673001004	30S ribosomal protein S11; Validated; Region: PRK05309
400673001005	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
400673001006	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
400673001007	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
400673001008	RNA binding surface [nucleotide binding]; other site
400673001009	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
400673001010	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
400673001011	alphaNTD homodimer interface [polypeptide binding]; other site
400673001012	alphaNTD - beta interaction site [polypeptide binding]; other site
400673001013	alphaNTD - beta' interaction site [polypeptide binding]; other site
400673001014	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
400673001015	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
400673001016	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
400673001017	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
400673001018	dimer interface [polypeptide binding]; other site
400673001019	ssDNA binding site [nucleotide binding]; other site
400673001020	tetramer (dimer of dimers) interface [polypeptide binding]; other site
400673001021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001022	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673001023	putative substrate translocation pore; other site
400673001024	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
400673001025	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
400673001026	putative NAD(P) binding site [chemical binding]; other site
400673001027	active site
400673001028	Phosphopantetheine attachment site; Region: PP-binding; cl09936
400673001029	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
400673001030	active site 2 [active]
400673001031	active site 1 [active]
400673001032	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
400673001033	active site 2 [active]
400673001034	dimer interface [polypeptide binding]; other site
400673001035	active site 1 [active]
400673001036	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
400673001037	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
400673001038	dimer interface [polypeptide binding]; other site
400673001039	active site
400673001040	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
400673001041	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
400673001042	dimer interface [polypeptide binding]; other site
400673001043	active site
400673001044	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
400673001045	putative acyl-acceptor binding pocket; other site
400673001046	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
400673001047	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
400673001048	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
400673001049	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
400673001050	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
400673001051	putative coenzyme Q binding site [chemical binding]; other site
400673001052	hypothetical protein; Validated; Region: PRK01777
400673001053	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
400673001054	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
400673001055	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
400673001056	metal binding site 2 [ion binding]; metal-binding site
400673001057	putative DNA binding helix; other site
400673001058	metal binding site 1 [ion binding]; metal-binding site
400673001059	dimer interface [polypeptide binding]; other site
400673001060	structural Zn2+ binding site [ion binding]; other site
400673001061	choline dehydrogenase; Validated; Region: PRK02106
400673001062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673001063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673001064	metal binding site [ion binding]; metal-binding site
400673001065	active site
400673001066	I-site; other site
400673001067	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
400673001068	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
400673001069	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
400673001070	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
400673001071	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673001072	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
400673001073	CoenzymeA binding site [chemical binding]; other site
400673001074	subunit interaction site [polypeptide binding]; other site
400673001075	PHB binding site; other site
400673001076	BON domain; Region: BON; pfam04972
400673001077	BON domain; Region: BON; pfam04972
400673001078	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673001079	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
400673001080	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
400673001081	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
400673001082	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
400673001083	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
400673001084	heat shock protein HtpX; Provisional; Region: PRK02870
400673001085	inner membrane transport permease; Provisional; Region: PRK15066
400673001086	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
400673001087	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
400673001088	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673001089	Walker A/P-loop; other site
400673001090	ATP binding site [chemical binding]; other site
400673001091	Q-loop/lid; other site
400673001092	ABC transporter signature motif; other site
400673001093	Walker B; other site
400673001094	D-loop; other site
400673001095	H-loop/switch region; other site
400673001096	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
400673001097	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
400673001098	Protein of unknown function DUF45; Region: DUF45; pfam01863
400673001099	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
400673001100	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
400673001101	DNA binding site [nucleotide binding]
400673001102	active site
400673001103	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
400673001104	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
400673001105	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
400673001106	RimM N-terminal domain; Region: RimM; pfam01782
400673001107	PRC-barrel domain; Region: PRC; pfam05239
400673001108	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
400673001109	signal recognition particle protein; Provisional; Region: PRK10867
400673001110	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
400673001111	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
400673001112	P loop; other site
400673001113	GTP binding site [chemical binding]; other site
400673001114	Signal peptide binding domain; Region: SRP_SPB; pfam02978
400673001115	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001116	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001117	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001118	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
400673001119	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
400673001120	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
400673001121	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
400673001122	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
400673001123	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
400673001124	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
400673001125	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
400673001126	UbiA prenyltransferase family; Region: UbiA; pfam01040
400673001127	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
400673001128	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
400673001129	Cu(I) binding site [ion binding]; other site
400673001130	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
400673001131	RimK-like ATP-grasp domain; Region: RimK; pfam08443
400673001132	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
400673001133	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
400673001134	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
400673001135	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
400673001136	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
400673001137	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
400673001138	putative active site [active]
400673001139	phosphogluconate dehydratase; Validated; Region: PRK09054
400673001140	6-phosphogluconate dehydratase; Region: edd; TIGR01196
400673001141	Glucokinase; Region: Glucokinase; pfam02685
400673001142	glucokinase, proteobacterial type; Region: glk; TIGR00749
400673001143	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
400673001144	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
400673001145	active site
400673001146	intersubunit interface [polypeptide binding]; other site
400673001147	catalytic residue [active]
400673001148	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
400673001149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001150	putative substrate translocation pore; other site
400673001151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001152	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
400673001153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673001154	salt bridge; other site
400673001155	non-specific DNA binding site [nucleotide binding]; other site
400673001156	sequence-specific DNA binding site [nucleotide binding]; other site
400673001157	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
400673001158	ferrochelatase; Reviewed; Region: hemH; PRK00035
400673001159	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
400673001160	C-terminal domain interface [polypeptide binding]; other site
400673001161	active site
400673001162	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
400673001163	active site
400673001164	N-terminal domain interface [polypeptide binding]; other site
400673001165	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
400673001166	DNA-binding site [nucleotide binding]; DNA binding site
400673001167	RNA-binding motif; other site
400673001168	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
400673001169	HIT family signature motif; other site
400673001170	catalytic residue [active]
400673001171	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
400673001172	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
400673001173	active site
400673001174	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
400673001175	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
400673001176	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673001177	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673001178	Predicted membrane protein [Function unknown]; Region: COG1289
400673001179	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
400673001180	Predicted transcriptional regulators [Transcription]; Region: COG1733
400673001181	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
400673001182	Uncharacterized conserved protein [Function unknown]; Region: COG4278
400673001183	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673001184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673001185	S-adenosylmethionine binding site [chemical binding]; other site
400673001186	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001187	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001188	Protein of unknown function (DUF3773); Region: DUF3773; pfam12608
400673001189	Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475
400673001190	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
400673001191	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
400673001192	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673001193	ligand binding site [chemical binding]; other site
400673001194	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673001195	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
400673001196	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
400673001197	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
400673001198	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
400673001199	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
400673001200	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
400673001201	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
400673001202	HNH nucleases; Region: HNHc; smart00507
400673001203	AAA-like domain; Region: AAA_10; pfam12846
400673001204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001205	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673001206	putative substrate translocation pore; other site
400673001207	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
400673001208	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
400673001209	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
400673001210	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
400673001211	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
400673001212	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
400673001213	purine monophosphate binding site [chemical binding]; other site
400673001214	dimer interface [polypeptide binding]; other site
400673001215	putative catalytic residues [active]
400673001216	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
400673001217	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
400673001218	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
400673001219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673001220	S-adenosylmethionine binding site [chemical binding]; other site
400673001221	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
400673001222	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
400673001223	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
400673001224	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
400673001225	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
400673001226	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
400673001227	carboxyltransferase (CT) interaction site; other site
400673001228	biotinylation site [posttranslational modification]; other site
400673001229	Dehydroquinase class II; Region: DHquinase_II; pfam01220
400673001230	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
400673001231	trimer interface [polypeptide binding]; other site
400673001232	active site
400673001233	dimer interface [polypeptide binding]; other site
400673001234	pyruvate carboxylase subunit B; Provisional; Region: PRK14042
400673001235	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
400673001236	active site
400673001237	catalytic residues [active]
400673001238	metal binding site [ion binding]; metal-binding site
400673001239	homodimer binding site [polypeptide binding]; other site
400673001240	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
400673001241	carboxyltransferase (CT) interaction site; other site
400673001242	biotinylation site [posttranslational modification]; other site
400673001243	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
400673001244	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
400673001245	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
400673001246	active site
400673001247	Zn binding site [ion binding]; other site
400673001248	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673001249	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
400673001250	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
400673001251	putative catalytic site [active]
400673001252	putative metal binding site [ion binding]; other site
400673001253	putative phosphate binding site [ion binding]; other site
400673001254	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
400673001255	active site
400673001256	intersubunit interface [polypeptide binding]; other site
400673001257	catalytic residue [active]
400673001258	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
400673001259	ferredoxin-NADP reductase; Provisional; Region: PRK10926
400673001260	FAD binding pocket [chemical binding]; other site
400673001261	FAD binding motif [chemical binding]; other site
400673001262	phosphate binding motif [ion binding]; other site
400673001263	beta-alpha-beta structure motif; other site
400673001264	NAD binding pocket [chemical binding]; other site
400673001265	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
400673001266	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
400673001267	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
400673001268	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
400673001269	dimerization domain swap beta strand [polypeptide binding]; other site
400673001270	regulatory protein interface [polypeptide binding]; other site
400673001271	active site
400673001272	regulatory phosphorylation site [posttranslational modification]; other site
400673001273	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
400673001274	30S subunit binding site; other site
400673001275	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
400673001276	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
400673001277	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
400673001278	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
400673001279	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
400673001280	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
400673001281	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
400673001282	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
400673001283	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
400673001284	oligomer interface [polypeptide binding]; other site
400673001285	active site
400673001286	metal binding site [ion binding]; metal-binding site
400673001287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673001288	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001289	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001290	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
400673001291	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
400673001292	HflK protein; Region: hflK; TIGR01933
400673001293	FtsH protease regulator HflC; Provisional; Region: PRK11029
400673001294	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
400673001295	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
400673001296	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
400673001297	GDP-binding site [chemical binding]; other site
400673001298	ACT binding site; other site
400673001299	IMP binding site; other site
400673001300	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
400673001301	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
400673001302	Arginine repressor [Transcription]; Region: ArgR; COG1438
400673001303	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
400673001304	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673001305	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673001306	substrate binding pocket [chemical binding]; other site
400673001307	membrane-bound complex binding site; other site
400673001308	hinge residues; other site
400673001309	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
400673001310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673001311	dimer interface [polypeptide binding]; other site
400673001312	conserved gate region; other site
400673001313	putative PBP binding loops; other site
400673001314	ABC-ATPase subunit interface; other site
400673001315	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
400673001316	ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229
400673001317	Walker A/P-loop; other site
400673001318	ATP binding site [chemical binding]; other site
400673001319	Q-loop/lid; other site
400673001320	ABC transporter signature motif; other site
400673001321	Walker B; other site
400673001322	D-loop; other site
400673001323	H-loop/switch region; other site
400673001324	argininosuccinate synthase; Provisional; Region: PRK13820
400673001325	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
400673001326	ANP binding site [chemical binding]; other site
400673001327	Substrate Binding Site II [chemical binding]; other site
400673001328	Substrate Binding Site I [chemical binding]; other site
400673001329	Lyase; Region: Lyase_1; pfam00206
400673001330	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
400673001331	active sites [active]
400673001332	tetramer interface [polypeptide binding]; other site
400673001333	ornithine carbamoyltransferase; Provisional; Region: PRK00779
400673001334	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
400673001335	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
400673001336	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
400673001337	active site
400673001338	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
400673001339	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
400673001340	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
400673001341	C-terminal peptidase (prc); Region: prc; TIGR00225
400673001342	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
400673001343	protein binding site [polypeptide binding]; other site
400673001344	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
400673001345	Catalytic dyad [active]
400673001346	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
400673001347	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
400673001348	Peptidase family M23; Region: Peptidase_M23; pfam01551
400673001349	phosphoglyceromutase; Provisional; Region: PRK05434
400673001350	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
400673001351	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
400673001352	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
400673001353	catalytic residue [active]
400673001354	putative FPP diphosphate  binding site; other site
400673001355	putative FPP binding hydrophobic cleft; other site
400673001356	dimer interface [polypeptide binding]; other site
400673001357	putative IPP diphosphate binding site; other site
400673001358	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
400673001359	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
400673001360	zinc metallopeptidase RseP; Provisional; Region: PRK10779
400673001361	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
400673001362	active site
400673001363	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
400673001364	protein binding site [polypeptide binding]; other site
400673001365	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
400673001366	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
400673001367	putative substrate binding region [chemical binding]; other site
400673001368	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
400673001369	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
400673001370	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
400673001371	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
400673001372	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
400673001373	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
400673001374	Surface antigen; Region: Bac_surface_Ag; pfam01103
400673001375	periplasmic chaperone; Provisional; Region: PRK10780
400673001376	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
400673001377	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
400673001378	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
400673001379	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
400673001380	trimer interface [polypeptide binding]; other site
400673001381	active site
400673001382	UDP-GlcNAc binding site [chemical binding]; other site
400673001383	lipid binding site [chemical binding]; lipid-binding site
400673001384	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
400673001385	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
400673001386	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
400673001387	active site
400673001388	camphor resistance protein CrcB; Provisional; Region: PRK14217
400673001389	seryl-tRNA synthetase; Provisional; Region: PRK05431
400673001390	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
400673001391	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
400673001392	dimer interface [polypeptide binding]; other site
400673001393	active site
400673001394	motif 1; other site
400673001395	motif 2; other site
400673001396	motif 3; other site
400673001397	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
400673001398	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
400673001399	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673001400	Methyltransferase domain; Region: Methyltransf_12; pfam08242
400673001401	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
400673001402	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
400673001403	active site
400673001404	catalytic tetrad [active]
400673001405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673001406	S-adenosylmethionine binding site [chemical binding]; other site
400673001407	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673001408	hypothetical protein; Provisional; Region: PRK08233
400673001409	AAA domain; Region: AAA_18; pfam13238
400673001410	active site
400673001411	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
400673001412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673001413	Coenzyme A binding pocket [chemical binding]; other site
400673001414	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
400673001415	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
400673001416	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
400673001417	Abi-like protein; Region: Abi_2; pfam07751
400673001418	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
400673001419	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
400673001420	active site
400673001421	DNA binding site [nucleotide binding]
400673001422	Int/Topo IB signature motif; other site
400673001423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673001424	non-specific DNA binding site [nucleotide binding]; other site
400673001425	Predicted transcriptional regulator [Transcription]; Region: COG2932
400673001426	salt bridge; other site
400673001427	sequence-specific DNA binding site [nucleotide binding]; other site
400673001428	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
400673001429	Catalytic site [active]
400673001430	Global regulator protein family; Region: CsrA; pfam02599
400673001431	conjugal transfer ATPase TrbB; Provisional; Region: PRK13894
400673001432	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
400673001433	ATP binding site [chemical binding]; other site
400673001434	Walker A motif; other site
400673001435	hexamer interface [polypeptide binding]; other site
400673001436	Walker B motif; other site
400673001437	TrbC/VIRB2 family; Region: TrbC; cl01583
400673001438	conjugal transfer protein TrbD; Provisional; Region: PRK13823
400673001439	conjugal transfer protein TrbE; Provisional; Region: PRK13891
400673001440	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
400673001441	conjugal transfer protein TrbF; Provisional; Region: PRK13887
400673001442	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
400673001443	VirB7 interaction site; other site
400673001444	conjugal transfer protein TrbH; Provisional; Region: PRK13883
400673001445	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
400673001446	conjugal transfer protein TrbI; Provisional; Region: PRK13881
400673001447	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
400673001448	conjugal transfer protein TrbJ; Provisional; Region: PRK13879
400673001449	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
400673001450	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
400673001451	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673001452	Walker A motif; other site
400673001453	ATP binding site [chemical binding]; other site
400673001454	Walker B motif; other site
400673001455	conjugal transfer peptidase TraF; Provisional; Region: PRK13884
400673001456	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
400673001457	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
400673001458	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
400673001459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
400673001460	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
400673001461	active site
400673001462	metal binding site [ion binding]; metal-binding site
400673001463	interdomain interaction site; other site
400673001464	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
400673001465	nudix motif; other site
400673001466	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
400673001467	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
400673001468	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
400673001469	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
400673001470	P-loop; other site
400673001471	conjugal transfer protein TraM; Provisional; Region: PRK13895
400673001472	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
400673001473	HsdM N-terminal domain; Region: HsdM_N; pfam12161
400673001474	Methyltransferase domain; Region: Methyltransf_26; pfam13659
400673001475	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
400673001476	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
400673001477	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
400673001478	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
400673001479	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
400673001480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673001481	ATP binding site [chemical binding]; other site
400673001482	putative Mg++ binding site [ion binding]; other site
400673001483	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
400673001484	Domain of unknown function DUF87; Region: DUF87; pfam01935
400673001485	AAA-like domain; Region: AAA_10; pfam12846
400673001486	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
400673001487	RNase_H superfamily; Region: RNase_H_2; pfam13482
400673001488	Part of AAA domain; Region: AAA_19; pfam13245
400673001489	AAA domain; Region: AAA_11; pfam13086
400673001490	AAA domain; Region: AAA_12; pfam13087
400673001491	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673001492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001493	putative substrate translocation pore; other site
400673001494	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
400673001495	Helix-turn-helix domain; Region: HTH_17; pfam12728
400673001496	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
400673001497	RDD family; Region: RDD; cl00746
400673001498	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
400673001499	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
400673001500	Iron-sulfur protein interface; other site
400673001501	proximal quinone binding site [chemical binding]; other site
400673001502	SdhD (CybS) interface [polypeptide binding]; other site
400673001503	proximal heme binding site [chemical binding]; other site
400673001504	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
400673001505	SdhC subunit interface [polypeptide binding]; other site
400673001506	proximal heme binding site [chemical binding]; other site
400673001507	cardiolipin binding site; other site
400673001508	Iron-sulfur protein interface; other site
400673001509	proximal quinone binding site [chemical binding]; other site
400673001510	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
400673001511	L-aspartate oxidase; Provisional; Region: PRK06175
400673001512	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
400673001513	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
400673001514	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
400673001515	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
400673001516	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
400673001517	TPP-binding site [chemical binding]; other site
400673001518	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
400673001519	dimer interface [polypeptide binding]; other site
400673001520	PYR/PP interface [polypeptide binding]; other site
400673001521	TPP binding site [chemical binding]; other site
400673001522	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
400673001523	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673001524	E3 interaction surface; other site
400673001525	lipoyl attachment site [posttranslational modification]; other site
400673001526	e3 binding domain; Region: E3_binding; pfam02817
400673001527	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
400673001528	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
400673001529	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
400673001530	CoA-ligase; Region: Ligase_CoA; pfam00549
400673001531	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
400673001532	CoA binding domain; Region: CoA_binding; smart00881
400673001533	CoA-ligase; Region: Ligase_CoA; pfam00549
400673001534	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
400673001535	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
400673001536	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
400673001537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001538	D-galactonate transporter; Region: 2A0114; TIGR00893
400673001539	putative substrate translocation pore; other site
400673001540	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
400673001541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
400673001542	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
400673001543	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
400673001544	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
400673001545	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673001546	active site
400673001547	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
400673001548	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
400673001549	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
400673001550	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
400673001551	active site
400673001552	(T/H)XGH motif; other site
400673001553	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
400673001554	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
400673001555	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
400673001556	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
400673001557	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673001558	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673001559	ligand binding site [chemical binding]; other site
400673001560	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
400673001561	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
400673001562	putative acyl-acceptor binding pocket; other site
400673001563	multidrug efflux system protein; Provisional; Region: PRK11431
400673001564	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673001565	Phosphotransferase enzyme family; Region: APH; pfam01636
400673001566	substrate binding site [chemical binding]; other site
400673001567	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
400673001568	active site
400673001569	DNA polymerase IV; Validated; Region: PRK02406
400673001570	DNA binding site [nucleotide binding]
400673001571	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
400673001572	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
400673001573	DNA binding site [nucleotide binding]
400673001574	catalytic residue [active]
400673001575	H2TH interface [polypeptide binding]; other site
400673001576	putative catalytic residues [active]
400673001577	turnover-facilitating residue; other site
400673001578	intercalation triad [nucleotide binding]; other site
400673001579	8OG recognition residue [nucleotide binding]; other site
400673001580	putative reading head residues; other site
400673001581	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
400673001582	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
400673001583	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
400673001584	Fatty acid desaturase; Region: FA_desaturase; pfam00487
400673001585	Di-iron ligands [ion binding]; other site
400673001586	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673001587	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
400673001588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673001589	NAD(P) binding site [chemical binding]; other site
400673001590	active site
400673001591	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
400673001592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673001593	NAD(P) binding site [chemical binding]; other site
400673001594	active site
400673001595	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
400673001596	Phasin protein; Region: Phasin_2; cl11491
400673001597	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
400673001598	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
400673001599	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
400673001600	putative peptidase; Provisional; Region: PRK11649
400673001601	Peptidase family M23; Region: Peptidase_M23; pfam01551
400673001602	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
400673001603	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
400673001604	active site
400673001605	HIGH motif; other site
400673001606	dimer interface [polypeptide binding]; other site
400673001607	KMSKS motif; other site
400673001608	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
400673001609	RNA binding surface [nucleotide binding]; other site
400673001610	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
400673001611	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
400673001612	hinge; other site
400673001613	active site
400673001614	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
400673001615	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
400673001616	trimer interface [polypeptide binding]; other site
400673001617	putative metal binding site [ion binding]; other site
400673001618	glutathione reductase; Validated; Region: PRK06116
400673001619	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
400673001620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673001621	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
400673001622	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
400673001623	adenosine deaminase; Provisional; Region: PRK09358
400673001624	active site
400673001625	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
400673001626	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
400673001627	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
400673001628	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
400673001629	hypothetical protein; Validated; Region: PRK00228
400673001630	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
400673001631	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
400673001632	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
400673001633	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
400673001634	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
400673001635	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
400673001636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673001637	Walker A motif; other site
400673001638	ATP binding site [chemical binding]; other site
400673001639	Walker B motif; other site
400673001640	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
400673001641	Membrane fusogenic activity; Region: BMFP; pfam04380
400673001642	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
400673001643	Nitrogen regulatory protein P-II; Region: P-II; smart00938
400673001644	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
400673001645	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
400673001646	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
400673001647	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
400673001648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673001649	catalytic residue [active]
400673001650	Uncharacterized conserved protein [Function unknown]; Region: COG0398
400673001651	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
400673001652	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
400673001653	putative acyl-acceptor binding pocket; other site
400673001654	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
400673001655	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
400673001656	acyl-activating enzyme (AAE) consensus motif; other site
400673001657	AMP binding site [chemical binding]; other site
400673001658	active site
400673001659	CoA binding site [chemical binding]; other site
400673001660	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
400673001661	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
400673001662	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
400673001663	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
400673001664	Transcriptional regulator; Region: Rrf2; pfam02082
400673001665	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
400673001666	putative ABC transporter; Region: ycf24; CHL00085
400673001667	FeS assembly ATPase SufC; Region: sufC; TIGR01978
400673001668	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
400673001669	Walker A/P-loop; other site
400673001670	ATP binding site [chemical binding]; other site
400673001671	Q-loop/lid; other site
400673001672	ABC transporter signature motif; other site
400673001673	Walker B; other site
400673001674	D-loop; other site
400673001675	H-loop/switch region; other site
400673001676	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
400673001677	FeS assembly protein SufD; Region: sufD; TIGR01981
400673001678	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
400673001679	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
400673001680	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
400673001681	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673001682	catalytic residue [active]
400673001683	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
400673001684	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
400673001685	trimerization site [polypeptide binding]; other site
400673001686	active site
400673001687	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
400673001688	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
400673001689	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
400673001690	motif 1; other site
400673001691	dimer interface [polypeptide binding]; other site
400673001692	active site
400673001693	motif 2; other site
400673001694	motif 3; other site
400673001695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673001696	S-adenosylmethionine binding site [chemical binding]; other site
400673001697	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
400673001698	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
400673001699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001700	putative substrate translocation pore; other site
400673001701	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673001702	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
400673001703	Domain of unknown function DUF21; Region: DUF21; pfam01595
400673001704	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
400673001705	Transporter associated domain; Region: CorC_HlyC; smart01091
400673001706	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
400673001707	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
400673001708	putative NAD(P) binding site [chemical binding]; other site
400673001709	putative substrate binding site [chemical binding]; other site
400673001710	catalytic Zn binding site [ion binding]; other site
400673001711	structural Zn binding site [ion binding]; other site
400673001712	dimer interface [polypeptide binding]; other site
400673001713	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
400673001714	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
400673001715	active site
400673001716	catalytic residues [active]
400673001717	metal binding site [ion binding]; metal-binding site
400673001718	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
400673001719	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
400673001720	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
400673001721	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
400673001722	CoA binding domain; Region: CoA_binding_2; pfam13380
400673001723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
400673001724	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
400673001725	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
400673001726	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673001727	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
400673001728	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
400673001729	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
400673001730	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
400673001731	Cupin domain; Region: Cupin_2; cl17218
400673001732	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
400673001733	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
400673001734	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
400673001735	Competence protein; Region: Competence; pfam03772
400673001736	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
400673001737	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
400673001738	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
400673001739	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
400673001740	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
400673001741	PilX N-terminal; Region: PilX_N; pfam14341
400673001742	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
400673001743	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
400673001744	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
400673001745	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
400673001746	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
400673001747	Type II transport protein GspH; Region: GspH; pfam12019
400673001748	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
400673001749	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
400673001750	NodB motif; other site
400673001751	putative active site [active]
400673001752	putative catalytic site [active]
400673001753	putative Zn binding site [ion binding]; other site
400673001754	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
400673001755	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
400673001756	thymidine kinase; Provisional; Region: PRK04296
400673001757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001758	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673001759	putative substrate translocation pore; other site
400673001760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001761	putative substrate translocation pore; other site
400673001762	D-galactonate transporter; Region: 2A0114; TIGR00893
400673001763	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
400673001764	phosphopentomutase; Provisional; Region: PRK05362
400673001765	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
400673001766	active site
400673001767	HslU subunit interaction site [polypeptide binding]; other site
400673001768	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
400673001769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673001770	Walker A motif; other site
400673001771	ATP binding site [chemical binding]; other site
400673001772	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
400673001773	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
400673001774	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
400673001775	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
400673001776	metal ion-dependent adhesion site (MIDAS); other site
400673001777	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
400673001778	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
400673001779	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
400673001780	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
400673001781	putative active site [active]
400673001782	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
400673001783	putative active site [active]
400673001784	putative catalytic site [active]
400673001785	putative DNA binding site [nucleotide binding]; other site
400673001786	putative phosphate binding site [ion binding]; other site
400673001787	metal binding site A [ion binding]; metal-binding site
400673001788	putative AP binding site [nucleotide binding]; other site
400673001789	putative metal binding site B [ion binding]; other site
400673001790	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
400673001791	putative catalytic site [active]
400673001792	putative phosphate binding site [ion binding]; other site
400673001793	active site
400673001794	metal binding site A [ion binding]; metal-binding site
400673001795	DNA binding site [nucleotide binding]
400673001796	putative AP binding site [nucleotide binding]; other site
400673001797	putative metal binding site B [ion binding]; other site
400673001798	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
400673001799	Malic enzyme, N-terminal domain; Region: malic; pfam00390
400673001800	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
400673001801	putative NAD(P) binding site [chemical binding]; other site
400673001802	D-galactonate transporter; Region: 2A0114; TIGR00893
400673001803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001804	putative substrate translocation pore; other site
400673001805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673001806	putative substrate translocation pore; other site
400673001807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673001808	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
400673001809	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
400673001810	aromatic amino acid transport protein; Region: araaP; TIGR00837
400673001811	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
400673001812	aromatic amino acid transport protein; Region: araaP; TIGR00837
400673001813	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
400673001814	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673001815	ligand binding site [chemical binding]; other site
400673001816	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
400673001817	putative active site [active]
400673001818	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
400673001819	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673001820	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
400673001821	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673001822	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
400673001823	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673001824	Walker A/P-loop; other site
400673001825	ATP binding site [chemical binding]; other site
400673001826	Q-loop/lid; other site
400673001827	ABC transporter signature motif; other site
400673001828	Walker B; other site
400673001829	D-loop; other site
400673001830	H-loop/switch region; other site
400673001831	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
400673001832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673001833	Walker A/P-loop; other site
400673001834	ATP binding site [chemical binding]; other site
400673001835	Q-loop/lid; other site
400673001836	ABC transporter signature motif; other site
400673001837	Walker B; other site
400673001838	D-loop; other site
400673001839	H-loop/switch region; other site
400673001840	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
400673001841	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
400673001842	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
400673001843	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
400673001844	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
400673001845	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
400673001846	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
400673001847	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673001848	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673001849	catalytic residue [active]
400673001850	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
400673001851	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
400673001852	substrate binding site [chemical binding]; other site
400673001853	hexamer interface [polypeptide binding]; other site
400673001854	metal binding site [ion binding]; metal-binding site
400673001855	DoxX; Region: DoxX; pfam07681
400673001856	hypothetical protein; Provisional; Region: PRK05409
400673001857	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
400673001858	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
400673001859	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
400673001860	nucleophile elbow; other site
400673001861	DoxX; Region: DoxX; pfam07681
400673001862	Predicted membrane protein [Function unknown]; Region: COG2259
400673001863	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
400673001864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673001865	acetoacetate decarboxylase; Provisional; Region: PRK02265
400673001866	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
400673001867	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
400673001868	cyclase homology domain; Region: CHD; cd07302
400673001869	nucleotidyl binding site; other site
400673001870	metal binding site [ion binding]; metal-binding site
400673001871	dimer interface [polypeptide binding]; other site
400673001872	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
400673001873	hypothetical protein; Provisional; Region: PRK05409
400673001874	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673001875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673001876	substrate binding pocket [chemical binding]; other site
400673001877	membrane-bound complex binding site; other site
400673001878	hinge residues; other site
400673001879	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
400673001880	metal binding triad; other site
400673001881	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
400673001882	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
400673001883	metal binding triad; other site
400673001884	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673001885	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673001886	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
400673001887	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
400673001888	Walker A/P-loop; other site
400673001889	ATP binding site [chemical binding]; other site
400673001890	Q-loop/lid; other site
400673001891	ABC transporter signature motif; other site
400673001892	Walker B; other site
400673001893	D-loop; other site
400673001894	H-loop/switch region; other site
400673001895	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
400673001896	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
400673001897	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
400673001898	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
400673001899	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673001900	FeS/SAM binding site; other site
400673001901	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
400673001902	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
400673001903	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
400673001904	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
400673001905	DsbD alpha interface [polypeptide binding]; other site
400673001906	catalytic residues [active]
400673001907	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
400673001908	oligomerisation interface [polypeptide binding]; other site
400673001909	mobile loop; other site
400673001910	roof hairpin; other site
400673001911	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
400673001912	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
400673001913	ring oligomerisation interface [polypeptide binding]; other site
400673001914	ATP/Mg binding site [chemical binding]; other site
400673001915	stacking interactions; other site
400673001916	hinge regions; other site
400673001917	Ferritin-like domain; Region: Ferritin; pfam00210
400673001918	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
400673001919	dimerization interface [polypeptide binding]; other site
400673001920	DPS ferroxidase diiron center [ion binding]; other site
400673001921	ion pore; other site
400673001922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673001923	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
400673001924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673001925	Mg2+ binding site [ion binding]; other site
400673001926	G-X-G motif; other site
400673001927	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
400673001928	anchoring element; other site
400673001929	dimer interface [polypeptide binding]; other site
400673001930	ATP binding site [chemical binding]; other site
400673001931	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
400673001932	active site
400673001933	metal binding site [ion binding]; metal-binding site
400673001934	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
400673001935	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
400673001936	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
400673001937	Walker A/P-loop; other site
400673001938	ATP binding site [chemical binding]; other site
400673001939	Q-loop/lid; other site
400673001940	ABC transporter signature motif; other site
400673001941	Walker B; other site
400673001942	D-loop; other site
400673001943	H-loop/switch region; other site
400673001944	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
400673001945	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
400673001946	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
400673001947	Walker A/P-loop; other site
400673001948	ATP binding site [chemical binding]; other site
400673001949	Q-loop/lid; other site
400673001950	ABC transporter signature motif; other site
400673001951	Walker B; other site
400673001952	D-loop; other site
400673001953	H-loop/switch region; other site
400673001954	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
400673001955	prolyl-tRNA synthetase; Provisional; Region: PRK09194
400673001956	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
400673001957	dimer interface [polypeptide binding]; other site
400673001958	motif 1; other site
400673001959	active site
400673001960	motif 2; other site
400673001961	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
400673001962	putative deacylase active site [active]
400673001963	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
400673001964	active site
400673001965	motif 3; other site
400673001966	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
400673001967	anticodon binding site; other site
400673001968	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
400673001969	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001970	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001971	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001972	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673001973	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673001974	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
400673001975	Sulfate transporter family; Region: Sulfate_transp; pfam00916
400673001976	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
400673001977	active site clefts [active]
400673001978	zinc binding site [ion binding]; other site
400673001979	dimer interface [polypeptide binding]; other site
400673001980	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
400673001981	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
400673001982	Ligand Binding Site [chemical binding]; other site
400673001983	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
400673001984	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
400673001985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673001986	S-adenosylmethionine binding site [chemical binding]; other site
400673001987	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
400673001988	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
400673001989	substrate-cofactor binding pocket; other site
400673001990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673001991	catalytic residue [active]
400673001992	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
400673001993	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
400673001994	NAD(P) binding site [chemical binding]; other site
400673001995	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
400673001996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673001997	Walker A/P-loop; other site
400673001998	ATP binding site [chemical binding]; other site
400673001999	Q-loop/lid; other site
400673002000	ABC transporter signature motif; other site
400673002001	Walker B; other site
400673002002	D-loop; other site
400673002003	H-loop/switch region; other site
400673002004	ABC transporter; Region: ABC_tran_2; pfam12848
400673002005	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673002006	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673002007	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
400673002008	Predicted transporter component [General function prediction only]; Region: COG2391
400673002009	Sulphur transport; Region: Sulf_transp; pfam04143
400673002010	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
400673002011	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673002012	formimidoylglutamase; Provisional; Region: PRK13775
400673002013	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
400673002014	putative active site [active]
400673002015	putative metal binding site [ion binding]; other site
400673002016	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673002017	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
400673002018	NAD(P) binding site [chemical binding]; other site
400673002019	active site
400673002020	imidazolonepropionase; Validated; Region: PRK09356
400673002021	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
400673002022	active site
400673002023	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
400673002024	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
400673002025	Predicted membrane protein [Function unknown]; Region: COG1297
400673002026	putative oligopeptide transporter, OPT family; Region: TIGR00733
400673002027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
400673002028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673002029	dimer interface [polypeptide binding]; other site
400673002030	phosphorylation site [posttranslational modification]
400673002031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673002032	ATP binding site [chemical binding]; other site
400673002033	Mg2+ binding site [ion binding]; other site
400673002034	G-X-G motif; other site
400673002035	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
400673002036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673002037	active site
400673002038	phosphorylation site [posttranslational modification]
400673002039	intermolecular recognition site; other site
400673002040	dimerization interface [polypeptide binding]; other site
400673002041	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
400673002042	DNA binding site [nucleotide binding]
400673002043	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
400673002044	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
400673002045	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
400673002046	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
400673002047	HIGH motif; other site
400673002048	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
400673002049	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
400673002050	active site
400673002051	KMSKS motif; other site
400673002052	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
400673002053	tRNA binding surface [nucleotide binding]; other site
400673002054	anticodon binding site; other site
400673002055	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
400673002056	multidrug efflux protein; Reviewed; Region: PRK09579
400673002057	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
400673002058	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673002059	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673002060	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002061	BON domain; Region: BON; pfam04972
400673002062	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
400673002063	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
400673002064	dimer interface [polypeptide binding]; other site
400673002065	active site
400673002066	glycine-pyridoxal phosphate binding site [chemical binding]; other site
400673002067	folate binding site [chemical binding]; other site
400673002068	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
400673002069	ATP cone domain; Region: ATP-cone; pfam03477
400673002070	transcription antitermination factor NusB; Region: nusB; TIGR01951
400673002071	putative RNA binding site [nucleotide binding]; other site
400673002072	thiamine monophosphate kinase; Provisional; Region: PRK05731
400673002073	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
400673002074	ATP binding site [chemical binding]; other site
400673002075	dimerization interface [polypeptide binding]; other site
400673002076	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
400673002077	tetramer interfaces [polypeptide binding]; other site
400673002078	binuclear metal-binding site [ion binding]; other site
400673002079	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
400673002080	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
400673002081	NAD synthetase; Provisional; Region: PRK13981
400673002082	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
400673002083	multimer interface [polypeptide binding]; other site
400673002084	active site
400673002085	catalytic triad [active]
400673002086	protein interface 1 [polypeptide binding]; other site
400673002087	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
400673002088	homodimer interface [polypeptide binding]; other site
400673002089	NAD binding pocket [chemical binding]; other site
400673002090	ATP binding pocket [chemical binding]; other site
400673002091	Mg binding site [ion binding]; other site
400673002092	active-site loop [active]
400673002093	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
400673002094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673002095	ATP binding site [chemical binding]; other site
400673002096	putative Mg++ binding site [ion binding]; other site
400673002097	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673002098	nucleotide binding region [chemical binding]; other site
400673002099	ATP-binding site [chemical binding]; other site
400673002100	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
400673002101	replicative DNA helicase; Region: DnaB; TIGR00665
400673002102	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
400673002103	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
400673002104	Walker A motif; other site
400673002105	ATP binding site [chemical binding]; other site
400673002106	Walker B motif; other site
400673002107	DNA binding loops [nucleotide binding]
400673002108	alanine racemase; Reviewed; Region: alr; PRK00053
400673002109	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
400673002110	active site
400673002111	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
400673002112	substrate binding site [chemical binding]; other site
400673002113	catalytic residues [active]
400673002114	dimer interface [polypeptide binding]; other site
400673002115	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
400673002116	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
400673002117	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
400673002118	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
400673002119	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
400673002120	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673002121	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673002122	metal binding site [ion binding]; metal-binding site
400673002123	active site
400673002124	I-site; other site
400673002125	lipoyl synthase; Provisional; Region: PRK05481
400673002126	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673002127	FeS/SAM binding site; other site
400673002128	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
400673002129	GIY-YIG motif/motif A; other site
400673002130	putative active site [active]
400673002131	putative metal binding site [ion binding]; other site
400673002132	POT family; Region: PTR2; cl17359
400673002133	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
400673002134	Methyltransferase domain; Region: Methyltransf_11; pfam08241
400673002135	S-adenosylmethionine binding site [chemical binding]; other site
400673002136	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
400673002137	Ligand Binding Site [chemical binding]; other site
400673002138	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
400673002139	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
400673002140	substrate binding site [chemical binding]; other site
400673002141	glutamase interaction surface [polypeptide binding]; other site
400673002142	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
400673002143	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
400673002144	putative active site [active]
400673002145	oxyanion strand; other site
400673002146	catalytic triad [active]
400673002147	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
400673002148	ligand binding site; other site
400673002149	tetramer interface; other site
400673002150	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
400673002151	NeuB family; Region: NeuB; pfam03102
400673002152	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
400673002153	NeuB binding interface [polypeptide binding]; other site
400673002154	putative substrate binding site [chemical binding]; other site
400673002155	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
400673002156	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
400673002157	active site
400673002158	homodimer interface [polypeptide binding]; other site
400673002159	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
400673002160	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
400673002161	putative trimer interface [polypeptide binding]; other site
400673002162	putative CoA binding site [chemical binding]; other site
400673002163	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
400673002164	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
400673002165	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
400673002166	inhibitor-cofactor binding pocket; inhibition site
400673002167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673002168	catalytic residue [active]
400673002169	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
400673002170	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
400673002171	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
400673002172	NADP binding site [chemical binding]; other site
400673002173	active site
400673002174	putative substrate binding site [chemical binding]; other site
400673002175	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
400673002176	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
400673002177	NAD binding site [chemical binding]; other site
400673002178	substrate binding site [chemical binding]; other site
400673002179	homodimer interface [polypeptide binding]; other site
400673002180	active site
400673002181	Phosphoglucose isomerase; Region: PGI; pfam00342
400673002182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673002183	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
400673002184	active site
400673002185	dimer interface [polypeptide binding]; other site
400673002186	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
400673002187	dimer interface [polypeptide binding]; other site
400673002188	active site
400673002189	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
400673002190	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
400673002191	substrate binding site; other site
400673002192	tetramer interface; other site
400673002193	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
400673002194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673002195	NAD(P) binding site [chemical binding]; other site
400673002196	active site
400673002197	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
400673002198	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
400673002199	Mg++ binding site [ion binding]; other site
400673002200	putative catalytic motif [active]
400673002201	putative substrate binding site [chemical binding]; other site
400673002202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673002203	binding surface
400673002204	TPR motif; other site
400673002205	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
400673002206	Phosphotransferase enzyme family; Region: APH; pfam01636
400673002207	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673002208	substrate binding site [chemical binding]; other site
400673002209	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
400673002210	NeuB family; Region: NeuB; pfam03102
400673002211	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
400673002212	NeuB binding interface [polypeptide binding]; other site
400673002213	putative substrate binding site [chemical binding]; other site
400673002214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673002215	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
400673002216	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
400673002217	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
400673002218	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
400673002219	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
400673002220	Walker A/P-loop; other site
400673002221	ATP binding site [chemical binding]; other site
400673002222	Q-loop/lid; other site
400673002223	ABC transporter signature motif; other site
400673002224	Walker B; other site
400673002225	D-loop; other site
400673002226	H-loop/switch region; other site
400673002227	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
400673002228	putative carbohydrate binding site [chemical binding]; other site
400673002229	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
400673002230	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
400673002231	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
400673002232	Probable Catalytic site; other site
400673002233	metal-binding site
400673002234	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
400673002235	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
400673002236	Probable Catalytic site; other site
400673002237	metal-binding site
400673002238	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
400673002239	carbon storage regulator; Provisional; Region: PRK01712
400673002240	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
400673002241	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
400673002242	Biotin operon repressor [Transcription]; Region: BirA; COG1654
400673002243	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
400673002244	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
400673002245	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
400673002246	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
400673002247	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
400673002248	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
400673002249	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
400673002250	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
400673002251	Ligand Binding Site [chemical binding]; other site
400673002252	TilS substrate binding domain; Region: TilS; pfam09179
400673002253	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
400673002254	Transposase IS200 like; Region: Y1_Tnp; cl00848
400673002255	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
400673002256	active site
400673002257	oxyanion hole [active]
400673002258	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
400673002259	catalytic triad [active]
400673002260	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
400673002261	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
400673002262	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
400673002263	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
400673002264	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
400673002265	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
400673002266	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
400673002267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673002268	muropeptide transporter; Reviewed; Region: ampG; PRK11902
400673002269	putative substrate translocation pore; other site
400673002270	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
400673002271	Quinolinate synthetase A protein; Region: NadA; cl00420
400673002272	L-aspartate oxidase; Provisional; Region: PRK09077
400673002273	L-aspartate oxidase; Provisional; Region: PRK06175
400673002274	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
400673002275	adenylosuccinate lyase; Provisional; Region: PRK09285
400673002276	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
400673002277	tetramer interface [polypeptide binding]; other site
400673002278	active site
400673002279	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
400673002280	putative transporter; Provisional; Region: PRK11660
400673002281	Sulfate transporter family; Region: Sulfate_transp; pfam00916
400673002282	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
400673002283	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
400673002284	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
400673002285	active site
400673002286	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
400673002287	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
400673002288	active site
400673002289	phosphoenolpyruvate synthase; Validated; Region: PRK06464
400673002290	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
400673002291	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
400673002292	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
400673002293	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
400673002294	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
400673002295	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
400673002296	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
400673002297	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
400673002298	dimerization interface [polypeptide binding]; other site
400673002299	active site
400673002300	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
400673002301	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
400673002302	active site
400673002303	homodimer interface [polypeptide binding]; other site
400673002304	hypothetical protein; Provisional; Region: PRK08201
400673002305	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
400673002306	metal binding site [ion binding]; metal-binding site
400673002307	putative dimer interface [polypeptide binding]; other site
400673002308	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
400673002309	rod shape-determining protein MreB; Provisional; Region: PRK13927
400673002310	MreB and similar proteins; Region: MreB_like; cd10225
400673002311	nucleotide binding site [chemical binding]; other site
400673002312	Mg binding site [ion binding]; other site
400673002313	putative protofilament interaction site [polypeptide binding]; other site
400673002314	RodZ interaction site [polypeptide binding]; other site
400673002315	rod shape-determining protein MreC; Provisional; Region: PRK13922
400673002316	rod shape-determining protein MreC; Region: MreC; pfam04085
400673002317	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
400673002318	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
400673002319	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
400673002320	active site
400673002321	isocitrate dehydrogenase; Validated; Region: PRK07362
400673002322	isocitrate dehydrogenase; Reviewed; Region: PRK07006
400673002323	Uncharacterized conserved protein [Function unknown]; Region: COG2127
400673002324	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
400673002325	Clp amino terminal domain; Region: Clp_N; pfam02861
400673002326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673002327	Walker A motif; other site
400673002328	ATP binding site [chemical binding]; other site
400673002329	Walker B motif; other site
400673002330	arginine finger; other site
400673002331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673002332	Walker A motif; other site
400673002333	ATP binding site [chemical binding]; other site
400673002334	Walker B motif; other site
400673002335	arginine finger; other site
400673002336	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
400673002337	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
400673002338	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
400673002339	putative metal binding site; other site
400673002340	Rhomboid family; Region: Rhomboid; cl11446
400673002341	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
400673002342	Peptidase family M23; Region: Peptidase_M23; pfam01551
400673002343	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
400673002344	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
400673002345	generic binding surface II; other site
400673002346	generic binding surface I; other site
400673002347	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
400673002348	Sporulation related domain; Region: SPOR; pfam05036
400673002349	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
400673002350	biofilm formation regulator HmsP; Provisional; Region: PRK11829
400673002351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
400673002352	dimerization interface [polypeptide binding]; other site
400673002353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673002354	metal binding site [ion binding]; metal-binding site
400673002355	active site
400673002356	I-site; other site
400673002357	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673002358	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
400673002359	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
400673002360	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
400673002361	hypothetical protein; Provisional; Region: PRK06194
400673002362	classical (c) SDRs; Region: SDR_c; cd05233
400673002363	NAD(P) binding site [chemical binding]; other site
400673002364	active site
400673002365	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
400673002366	active site
400673002367	ribulose/triose binding site [chemical binding]; other site
400673002368	phosphate binding site [ion binding]; other site
400673002369	substrate (anthranilate) binding pocket [chemical binding]; other site
400673002370	product (indole) binding pocket [chemical binding]; other site
400673002371	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
400673002372	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
400673002373	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
400673002374	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
400673002375	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
400673002376	glutamine binding [chemical binding]; other site
400673002377	catalytic triad [active]
400673002378	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
400673002379	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
400673002380	Walker A/P-loop; other site
400673002381	ATP binding site [chemical binding]; other site
400673002382	Q-loop/lid; other site
400673002383	ABC transporter signature motif; other site
400673002384	Walker B; other site
400673002385	D-loop; other site
400673002386	H-loop/switch region; other site
400673002387	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
400673002388	OstA-like protein; Region: OstA; pfam03968
400673002389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
400673002390	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
400673002391	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
400673002392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673002393	active site
400673002394	motif I; other site
400673002395	motif II; other site
400673002396	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
400673002397	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
400673002398	putative active site [active]
400673002399	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
400673002400	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
400673002401	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
400673002402	Walker A/P-loop; other site
400673002403	ATP binding site [chemical binding]; other site
400673002404	Q-loop/lid; other site
400673002405	ABC transporter signature motif; other site
400673002406	Walker B; other site
400673002407	D-loop; other site
400673002408	H-loop/switch region; other site
400673002409	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
400673002410	Permease; Region: Permease; cl00510
400673002411	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
400673002412	mce related protein; Region: MCE; pfam02470
400673002413	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
400673002414	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
400673002415	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
400673002416	anti sigma factor interaction site; other site
400673002417	regulatory phosphorylation site [posttranslational modification]; other site
400673002418	BolA-like protein; Region: BolA; cl00386
400673002419	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
400673002420	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
400673002421	hinge; other site
400673002422	active site
400673002423	Uncharacterized conserved protein [Function unknown]; Region: COG0327
400673002424	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
400673002425	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
400673002426	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
400673002427	Walker A/P-loop; other site
400673002428	ATP binding site [chemical binding]; other site
400673002429	Q-loop/lid; other site
400673002430	ABC transporter signature motif; other site
400673002431	Walker B; other site
400673002432	D-loop; other site
400673002433	H-loop/switch region; other site
400673002434	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
400673002435	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
400673002436	FtsX-like permease family; Region: FtsX; pfam02687
400673002437	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673002438	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673002439	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002440	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
400673002441	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
400673002442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673002443	Walker A motif; other site
400673002444	ATP binding site [chemical binding]; other site
400673002445	Walker B motif; other site
400673002446	arginine finger; other site
400673002447	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
400673002448	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
400673002449	putative inner membrane peptidase; Provisional; Region: PRK11778
400673002450	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
400673002451	tandem repeat interface [polypeptide binding]; other site
400673002452	oligomer interface [polypeptide binding]; other site
400673002453	active site residues [active]
400673002454	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540
400673002455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673002456	Walker A/P-loop; other site
400673002457	ATP binding site [chemical binding]; other site
400673002458	Q-loop/lid; other site
400673002459	ABC transporter signature motif; other site
400673002460	Walker B; other site
400673002461	D-loop; other site
400673002462	H-loop/switch region; other site
400673002463	CcmB protein; Region: CcmB; cl17444
400673002464	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
400673002465	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
400673002466	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
400673002467	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
400673002468	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
400673002469	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
400673002470	catalytic residues [active]
400673002471	central insert; other site
400673002472	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
400673002473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673002474	binding surface
400673002475	TPR motif; other site
400673002476	Dodecin; Region: Dodecin; pfam07311
400673002477	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
400673002478	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
400673002479	active site
400673002480	DNA binding site [nucleotide binding]
400673002481	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
400673002482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673002483	ATP binding site [chemical binding]; other site
400673002484	putative Mg++ binding site [ion binding]; other site
400673002485	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673002486	nucleotide binding region [chemical binding]; other site
400673002487	ATP-binding site [chemical binding]; other site
400673002488	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
400673002489	HRDC domain; Region: HRDC; pfam00570
400673002490	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
400673002491	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
400673002492	active site
400673002493	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
400673002494	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
400673002495	substrate binding site [chemical binding]; other site
400673002496	oxyanion hole (OAH) forming residues; other site
400673002497	trimer interface [polypeptide binding]; other site
400673002498	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
400673002499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
400673002500	substrate binding site [chemical binding]; other site
400673002501	oxyanion hole (OAH) forming residues; other site
400673002502	trimer interface [polypeptide binding]; other site
400673002503	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
400673002504	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
400673002505	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
400673002506	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
400673002507	G1 box; other site
400673002508	putative GEF interaction site [polypeptide binding]; other site
400673002509	GTP/Mg2+ binding site [chemical binding]; other site
400673002510	Switch I region; other site
400673002511	G2 box; other site
400673002512	G3 box; other site
400673002513	Switch II region; other site
400673002514	G4 box; other site
400673002515	G5 box; other site
400673002516	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
400673002517	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
400673002518	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
400673002519	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
400673002520	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
400673002521	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
400673002522	ligand binding site [chemical binding]; other site
400673002523	homodimer interface [polypeptide binding]; other site
400673002524	NAD(P) binding site [chemical binding]; other site
400673002525	trimer interface B [polypeptide binding]; other site
400673002526	trimer interface A [polypeptide binding]; other site
400673002527	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
400673002528	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
400673002529	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
400673002530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673002531	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673002532	metal binding site [ion binding]; metal-binding site
400673002533	active site
400673002534	I-site; other site
400673002535	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
400673002536	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
400673002537	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
400673002538	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
400673002539	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
400673002540	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
400673002541	metal binding site [ion binding]; metal-binding site
400673002542	dimer interface [polypeptide binding]; other site
400673002543	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
400673002544	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
400673002545	trimer interface [polypeptide binding]; other site
400673002546	active site
400673002547	substrate binding site [chemical binding]; other site
400673002548	CoA binding site [chemical binding]; other site
400673002549	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
400673002550	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
400673002551	putative acyl-acceptor binding pocket; other site
400673002552	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
400673002553	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
400673002554	homodimer interface [polypeptide binding]; other site
400673002555	substrate-cofactor binding pocket; other site
400673002556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673002557	catalytic residue [active]
400673002558	PAS fold; Region: PAS_7; pfam12860
400673002559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673002560	PAS domain; Region: PAS_9; pfam13426
400673002561	putative active site [active]
400673002562	heme pocket [chemical binding]; other site
400673002563	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673002564	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673002565	metal binding site [ion binding]; metal-binding site
400673002566	active site
400673002567	I-site; other site
400673002568	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673002569	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
400673002570	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
400673002571	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
400673002572	FAD binding domain; Region: FAD_binding_4; pfam01565
400673002573	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
400673002574	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
400673002575	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673002576	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
400673002577	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
400673002578	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
400673002579	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
400673002580	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
400673002581	minor groove reading motif; other site
400673002582	helix-hairpin-helix signature motif; other site
400673002583	substrate binding pocket [chemical binding]; other site
400673002584	active site
400673002585	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
400673002586	DNA binding and oxoG recognition site [nucleotide binding]
400673002587	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
400673002588	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
400673002589	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
400673002590	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
400673002591	protein binding site [polypeptide binding]; other site
400673002592	Isochorismatase family; Region: Isochorismatase; pfam00857
400673002593	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
400673002594	catalytic triad [active]
400673002595	dimer interface [polypeptide binding]; other site
400673002596	conserved cis-peptide bond; other site
400673002597	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
400673002598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673002599	NAD(P) binding site [chemical binding]; other site
400673002600	active site
400673002601	FlgN protein; Region: FlgN; pfam05130
400673002602	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
400673002603	SAF-like; Region: SAF_2; pfam13144
400673002604	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
400673002605	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
400673002606	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673002607	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
400673002608	nucleotide binding site [chemical binding]; other site
400673002609	Type III pantothenate kinase; Region: Pan_kinase; cl17198
400673002610	cell division protein MraZ; Reviewed; Region: PRK00326
400673002611	MraZ protein; Region: MraZ; pfam02381
400673002612	MraZ protein; Region: MraZ; pfam02381
400673002613	MraW methylase family; Region: Methyltransf_5; cl17771
400673002614	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
400673002615	Cell division protein FtsL; Region: FtsL; pfam04999
400673002616	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
400673002617	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
400673002618	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
400673002619	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
400673002620	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
400673002621	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
400673002622	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673002623	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
400673002624	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
400673002625	ligand binding site [chemical binding]; other site
400673002626	NAD binding site [chemical binding]; other site
400673002627	catalytic site [active]
400673002628	homodimer interface [polypeptide binding]; other site
400673002629	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
400673002630	Peptidase family M50; Region: Peptidase_M50; pfam02163
400673002631	active site
400673002632	putative substrate binding region [chemical binding]; other site
400673002633	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
400673002634	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
400673002635	active site
400673002636	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
400673002637	Ligand binding site [chemical binding]; other site
400673002638	Electron transfer flavoprotein domain; Region: ETF; pfam01012
400673002639	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
400673002640	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
400673002641	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
400673002642	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
400673002643	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
400673002644	hexamer interface [polypeptide binding]; other site
400673002645	ligand binding site [chemical binding]; other site
400673002646	putative active site [active]
400673002647	NAD(P) binding site [chemical binding]; other site
400673002648	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
400673002649	Transglycosylase; Region: Transgly; pfam00912
400673002650	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
400673002651	Cell division protein FtsA; Region: FtsA; cl17206
400673002652	Competence protein A; Region: Competence_A; pfam11104
400673002653	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
400673002654	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
400673002655	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
400673002656	Pilus assembly protein, PilO; Region: PilO; pfam04350
400673002657	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
400673002658	Pilus assembly protein, PilP; Region: PilP; pfam04351
400673002659	AMIN domain; Region: AMIN; pfam11741
400673002660	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
400673002661	Secretin and TonB N terminus short domain; Region: STN; smart00965
400673002662	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
400673002663	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
400673002664	shikimate kinase; Reviewed; Region: aroK; PRK00131
400673002665	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
400673002666	ADP binding site [chemical binding]; other site
400673002667	magnesium binding site [ion binding]; other site
400673002668	putative shikimate binding site; other site
400673002669	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
400673002670	active site
400673002671	dimer interface [polypeptide binding]; other site
400673002672	metal binding site [ion binding]; metal-binding site
400673002673	AAA domain; Region: AAA_22; pfam13401
400673002674	Sporulation related domain; Region: SPOR; pfam05036
400673002675	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
400673002676	Ligand Binding Site [chemical binding]; other site
400673002677	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
400673002678	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
400673002679	active site
400673002680	Riboflavin kinase; Region: Flavokinase; smart00904
400673002681	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
400673002682	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673002683	active site
400673002684	HIGH motif; other site
400673002685	nucleotide binding site [chemical binding]; other site
400673002686	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
400673002687	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
400673002688	active site
400673002689	KMSKS motif; other site
400673002690	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
400673002691	tRNA binding surface [nucleotide binding]; other site
400673002692	anticodon binding site; other site
400673002693	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
400673002694	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
400673002695	lipoprotein signal peptidase; Provisional; Region: PRK14787
400673002696	Class I aldolases; Region: Aldolase_Class_I; cl17187
400673002697	catalytic residue [active]
400673002698	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
400673002699	GTPase Era; Reviewed; Region: era; PRK00089
400673002700	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
400673002701	G1 box; other site
400673002702	GTP/Mg2+ binding site [chemical binding]; other site
400673002703	Switch I region; other site
400673002704	G2 box; other site
400673002705	Switch II region; other site
400673002706	G3 box; other site
400673002707	G4 box; other site
400673002708	G5 box; other site
400673002709	KH domain; Region: KH_2; pfam07650
400673002710	Recombination protein O N terminal; Region: RecO_N; pfam11967
400673002711	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
400673002712	Recombination protein O C terminal; Region: RecO_C; pfam02565
400673002713	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
400673002714	Leucine-rich repeats; other site
400673002715	Substrate binding site [chemical binding]; other site
400673002716	Leucine rich repeat; Region: LRR_8; pfam13855
400673002717	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
400673002718	active site
400673002719	hydrophilic channel; other site
400673002720	dimerization interface [polypeptide binding]; other site
400673002721	catalytic residues [active]
400673002722	active site lid [active]
400673002723	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
400673002724	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
400673002725	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
400673002726	dimer interface [polypeptide binding]; other site
400673002727	PYR/PP interface [polypeptide binding]; other site
400673002728	TPP binding site [chemical binding]; other site
400673002729	substrate binding site [chemical binding]; other site
400673002730	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
400673002731	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
400673002732	TPP-binding site [chemical binding]; other site
400673002733	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
400673002734	YccA-like proteins; Region: YccA_like; cd10433
400673002735	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
400673002736	nitrilase; Region: PLN02798
400673002737	putative active site [active]
400673002738	catalytic triad [active]
400673002739	dimer interface [polypeptide binding]; other site
400673002740	protease TldD; Provisional; Region: tldD; PRK10735
400673002741	hypothetical protein; Provisional; Region: PRK10279
400673002742	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
400673002743	active site
400673002744	nucleophile elbow; other site
400673002745	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
400673002746	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
400673002747	acyl-activating enzyme (AAE) consensus motif; other site
400673002748	putative AMP binding site [chemical binding]; other site
400673002749	putative active site [active]
400673002750	putative CoA binding site [chemical binding]; other site
400673002751	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
400673002752	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
400673002753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673002754	ATP binding site [chemical binding]; other site
400673002755	putative Mg++ binding site [ion binding]; other site
400673002756	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673002757	nucleotide binding region [chemical binding]; other site
400673002758	ATP-binding site [chemical binding]; other site
400673002759	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
400673002760	RmuC family; Region: RmuC; pfam02646
400673002761	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
400673002762	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
400673002763	nucleotide binding pocket [chemical binding]; other site
400673002764	K-X-D-G motif; other site
400673002765	catalytic site [active]
400673002766	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
400673002767	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
400673002768	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
400673002769	Dimer interface [polypeptide binding]; other site
400673002770	BRCT sequence motif; other site
400673002771	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
400673002772	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
400673002773	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
400673002774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673002775	dimer interface [polypeptide binding]; other site
400673002776	conserved gate region; other site
400673002777	putative PBP binding loops; other site
400673002778	ABC-ATPase subunit interface; other site
400673002779	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
400673002780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673002781	dimer interface [polypeptide binding]; other site
400673002782	conserved gate region; other site
400673002783	putative PBP binding loops; other site
400673002784	ABC-ATPase subunit interface; other site
400673002785	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
400673002786	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
400673002787	putative active site [active]
400673002788	putative PHP Thumb interface [polypeptide binding]; other site
400673002789	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
400673002790	generic binding surface II; other site
400673002791	generic binding surface I; other site
400673002792	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
400673002793	UbiA prenyltransferase family; Region: UbiA; pfam01040
400673002794	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
400673002795	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
400673002796	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
400673002797	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
400673002798	NAD(P) binding site [chemical binding]; other site
400673002799	homodimer interface [polypeptide binding]; other site
400673002800	substrate binding site [chemical binding]; other site
400673002801	active site
400673002802	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
400673002803	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
400673002804	nucleotide binding site [chemical binding]; other site
400673002805	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
400673002806	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
400673002807	Antirestriction protein (ArdA); Region: ArdA; pfam07275
400673002808	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
400673002809	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
400673002810	dimer interface [polypeptide binding]; other site
400673002811	ssDNA binding site [nucleotide binding]; other site
400673002812	tetramer (dimer of dimers) interface [polypeptide binding]; other site
400673002813	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
400673002814	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
400673002815	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
400673002816	Integrase; Region: Integrase_1; pfam12835
400673002817	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673002818	active site
400673002819	ATP binding site [chemical binding]; other site
400673002820	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673002821	Coenzyme A binding pocket [chemical binding]; other site
400673002822	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
400673002823	active site
400673002824	NTP binding site [chemical binding]; other site
400673002825	metal binding triad [ion binding]; metal-binding site
400673002826	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
400673002827	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
400673002828	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673002829	Coenzyme A binding pocket [chemical binding]; other site
400673002830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673002831	Coenzyme A binding pocket [chemical binding]; other site
400673002832	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
400673002833	active site
400673002834	ATP binding site [chemical binding]; other site
400673002835	substrate binding site [chemical binding]; other site
400673002836	activation loop (A-loop); other site
400673002837	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
400673002838	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
400673002839	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
400673002840	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
400673002841	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
400673002842	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
400673002843	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
400673002844	Domain of unknown function DUF87; Region: DUF87; pfam01935
400673002845	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
400673002846	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
400673002847	basic region leucin zipper; Region: BRLZ; smart00338
400673002848	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
400673002849	Protein of unknown function (DUF2895); Region: DUF2895; pfam11444
400673002850	conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750
400673002851	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
400673002852	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
400673002853	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
400673002854	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
400673002855	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
400673002856	Global regulator protein family; Region: CsrA; pfam02599
400673002857	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
400673002858	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
400673002859	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673002860	non-specific DNA binding site [nucleotide binding]; other site
400673002861	salt bridge; other site
400673002862	sequence-specific DNA binding site [nucleotide binding]; other site
400673002863	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
400673002864	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
400673002865	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673002866	E3 interaction surface; other site
400673002867	lipoyl attachment site [posttranslational modification]; other site
400673002868	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002869	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
400673002870	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673002871	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
400673002872	metal-binding site [ion binding]
400673002873	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673002874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673002875	motif II; other site
400673002876	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
400673002877	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
400673002878	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673002879	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
400673002880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673002881	motif II; other site
400673002882	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
400673002883	Outer membrane efflux protein; Region: OEP; pfam02321
400673002884	Outer membrane efflux protein; Region: OEP; pfam02321
400673002885	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673002886	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002887	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
400673002888	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
400673002889	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
400673002890	Beta-Casp domain; Region: Beta-Casp; smart01027
400673002891	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
400673002892	thymidine phosphorylase; Provisional; Region: PRK04350
400673002893	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
400673002894	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
400673002895	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
400673002896	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
400673002897	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
400673002898	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673002899	active site
400673002900	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673002901	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673002902	Soluble P-type ATPase [General function prediction only]; Region: COG4087
400673002903	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673002904	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673002905	metal binding site [ion binding]; metal-binding site
400673002906	active site
400673002907	I-site; other site
400673002908	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
400673002909	Outer membrane efflux protein; Region: OEP; pfam02321
400673002910	Outer membrane efflux protein; Region: OEP; pfam02321
400673002911	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
400673002912	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
400673002913	carboxyltransferase (CT) interaction site; other site
400673002914	biotinylation site [posttranslational modification]; other site
400673002915	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002916	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
400673002917	Protein export membrane protein; Region: SecD_SecF; cl14618
400673002918	Leucine carboxyl methyltransferase; Region: LCM; cl01306
400673002919	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
400673002920	Uncharacterized conserved protein [Function unknown]; Region: COG4278
400673002921	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
400673002922	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
400673002923	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673002924	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673002925	Outer membrane efflux protein; Region: OEP; pfam02321
400673002926	Outer membrane efflux protein; Region: OEP; pfam02321
400673002927	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
400673002928	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
400673002929	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
400673002930	Multicopper oxidase; Region: Cu-oxidase; pfam00394
400673002931	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
400673002932	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
400673002933	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
400673002934	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
400673002935	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
400673002936	NAD(P) binding site [chemical binding]; other site
400673002937	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
400673002938	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
400673002939	heme-binding residues [chemical binding]; other site
400673002940	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
400673002941	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
400673002942	FAD binding pocket [chemical binding]; other site
400673002943	FAD binding motif [chemical binding]; other site
400673002944	phosphate binding motif [ion binding]; other site
400673002945	beta-alpha-beta structure motif; other site
400673002946	NAD binding pocket [chemical binding]; other site
400673002947	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
400673002948	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
400673002949	catalytic loop [active]
400673002950	iron binding site [ion binding]; other site
400673002951	core domain interface [polypeptide binding]; other site
400673002952	delta subunit interface [polypeptide binding]; other site
400673002953	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
400673002954	epsilon subunit interface [polypeptide binding]; other site
400673002955	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
400673002956	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673002957	Walker A motif; other site
400673002958	ATP binding site [chemical binding]; other site
400673002959	Walker B motif; other site
400673002960	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
400673002961	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
400673002962	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
400673002963	ATP synthase subunit C; Region: ATP-synt_C; cl00466
400673002964	F0F1 ATP synthase subunit A; Provisional; Region: PRK13420
400673002965	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
400673002966	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
400673002967	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033
400673002968	gamma subunit interface [polypeptide binding]; other site
400673002969	epsilon subunit interface [polypeptide binding]; other site
400673002970	LBP interface [polypeptide binding]; other site
400673002971	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
400673002972	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
400673002973	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
400673002974	alpha subunit interaction interface [polypeptide binding]; other site
400673002975	Walker A motif; other site
400673002976	ATP binding site [chemical binding]; other site
400673002977	Walker B motif; other site
400673002978	inhibitor binding site; inhibition site
400673002979	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
400673002980	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
400673002981	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
400673002982	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
400673002983	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
400673002984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673002985	NAD(P) binding site [chemical binding]; other site
400673002986	active site
400673002987	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
400673002988	DNA-binding site [nucleotide binding]; DNA binding site
400673002989	RNA-binding motif; other site
400673002990	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673002991	Sel1-like repeats; Region: SEL1; smart00671
400673002992	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673002993	Sel1-like repeats; Region: SEL1; smart00671
400673002994	Sel1-like repeats; Region: SEL1; smart00671
400673002995	Sel1-like repeats; Region: SEL1; smart00671
400673002996	Sel1 repeat; Region: Sel1; pfam08238
400673002997	Sel1-like repeats; Region: SEL1; smart00671
400673002998	citrate-proton symporter; Provisional; Region: PRK15075
400673002999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003000	putative substrate translocation pore; other site
400673003001	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
400673003002	active site
400673003003	catalytic residues [active]
400673003004	metal binding site [ion binding]; metal-binding site
400673003005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673003006	non-specific DNA binding site [nucleotide binding]; other site
400673003007	salt bridge; other site
400673003008	sequence-specific DNA binding site [nucleotide binding]; other site
400673003009	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
400673003010	Abi-like protein; Region: Abi_2; pfam07751
400673003011	integrase; Provisional; Region: PRK09692
400673003012	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
400673003013	active site
400673003014	Int/Topo IB signature motif; other site
400673003015	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003016	Coenzyme A binding pocket [chemical binding]; other site
400673003017	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
400673003018	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
400673003019	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
400673003020	Domain of unknown function (DUF927); Region: DUF927; pfam06048
400673003021	Helix-turn-helix domain; Region: HTH_17; pfam12728
400673003022	DNA binding domain, excisionase family; Region: excise; TIGR01764
400673003023	PIN domain; Region: PIN_3; pfam13470
400673003024	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
400673003025	active site
400673003026	DNA binding site [nucleotide binding]
400673003027	Int/Topo IB signature motif; other site
400673003028	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
400673003029	Helix-turn-helix domain; Region: HTH_38; pfam13936
400673003030	Homeodomain-like domain; Region: HTH_32; pfam13565
400673003031	Integrase core domain; Region: rve; pfam00665
400673003032	Domain of unknown function (DUF927); Region: DUF927; pfam06048
400673003033	Helix-turn-helix domain; Region: HTH_17; pfam12728
400673003034	RelB antitoxin; Region: RelB; cl01171
400673003035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
400673003036	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
400673003037	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
400673003038	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
400673003039	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003040	Coenzyme A binding pocket [chemical binding]; other site
400673003041	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
400673003042	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
400673003043	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673003044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673003045	S-adenosylmethionine binding site [chemical binding]; other site
400673003046	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
400673003047	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003048	Coenzyme A binding pocket [chemical binding]; other site
400673003049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673003050	AAA domain; Region: AAA_23; pfam13476
400673003051	AAA domain; Region: AAA_21; pfam13304
400673003052	Walker A/P-loop; other site
400673003053	ATP binding site [chemical binding]; other site
400673003054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673003055	Walker B; other site
400673003056	D-loop; other site
400673003057	H-loop/switch region; other site
400673003058	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
400673003059	putative active site [active]
400673003060	putative metal-binding site [ion binding]; other site
400673003061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
400673003062	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
400673003063	Fic family protein [Function unknown]; Region: COG3177
400673003064	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
400673003065	Fic/DOC family; Region: Fic; pfam02661
400673003066	Fic family protein [Function unknown]; Region: COG3177
400673003067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003068	Coenzyme A binding pocket [chemical binding]; other site
400673003069	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
400673003070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673003071	motif II; other site
400673003072	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
400673003073	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
400673003074	putative transposase OrfB; Reviewed; Region: PHA02517
400673003075	HTH-like domain; Region: HTH_21; pfam13276
400673003076	Integrase core domain; Region: rve; pfam00665
400673003077	Integrase core domain; Region: rve_2; pfam13333
400673003078	Transposase; Region: HTH_Tnp_1; pfam01527
400673003079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
400673003080	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673003081	Phosphotransferase enzyme family; Region: APH; pfam01636
400673003082	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673003083	methionine sulfoxide reductase B; Provisional; Region: PRK00222
400673003084	SelR domain; Region: SelR; pfam01641
400673003085	Predicted membrane protein [Function unknown]; Region: COG4325
400673003086	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
400673003087	EamA-like transporter family; Region: EamA; cl17759
400673003088	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673003089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673003090	PAS domain; Region: PAS_9; pfam13426
400673003091	putative active site [active]
400673003092	heme pocket [chemical binding]; other site
400673003093	PAS domain; Region: PAS_9; pfam13426
400673003094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673003095	putative active site [active]
400673003096	heme pocket [chemical binding]; other site
400673003097	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673003098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673003099	metal binding site [ion binding]; metal-binding site
400673003100	active site
400673003101	I-site; other site
400673003102	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673003103	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
400673003104	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
400673003105	tetramer interface [polypeptide binding]; other site
400673003106	dimer interface [polypeptide binding]; other site
400673003107	circadian clock protein KaiC; Reviewed; Region: PRK09302
400673003108	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673003109	ATP binding site [chemical binding]; other site
400673003110	Walker B motif; other site
400673003111	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673003112	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673003113	Walker A motif; other site
400673003114	Walker A motif; other site
400673003115	ATP binding site [chemical binding]; other site
400673003116	ATP binding site [chemical binding]; other site
400673003117	Walker B motif; other site
400673003118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
400673003119	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673003120	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
400673003121	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
400673003122	active site
400673003123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003124	Coenzyme A binding pocket [chemical binding]; other site
400673003125	Beta-lactamase; Region: Beta-lactamase; pfam00144
400673003126	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
400673003127	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
400673003128	catalytic core [active]
400673003129	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
400673003130	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673003131	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673003132	catalytic residue [active]
400673003133	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003134	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
400673003135	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003136	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673003137	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673003138	substrate binding pocket [chemical binding]; other site
400673003139	membrane-bound complex binding site; other site
400673003140	hinge residues; other site
400673003141	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673003142	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673003143	substrate binding pocket [chemical binding]; other site
400673003144	membrane-bound complex binding site; other site
400673003145	hinge residues; other site
400673003146	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
400673003147	Soluble P-type ATPase [General function prediction only]; Region: COG4087
400673003148	putative cation:proton antiport protein; Provisional; Region: PRK10669
400673003149	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
400673003150	TrkA-N domain; Region: TrkA_N; pfam02254
400673003151	Winged helix-turn helix; Region: HTH_29; pfam13551
400673003152	Helix-turn-helix domain; Region: HTH_28; pfam13518
400673003153	Integrase core domain; Region: rve; pfam00665
400673003154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
400673003155	Integrase core domain; Region: rve_3; pfam13683
400673003156	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
400673003157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
400673003158	dimerization interface [polypeptide binding]; other site
400673003159	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
400673003160	cyclase homology domain; Region: CHD; cd07302
400673003161	nucleotidyl binding site; other site
400673003162	metal binding site [ion binding]; metal-binding site
400673003163	dimer interface [polypeptide binding]; other site
400673003164	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
400673003165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673003166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673003167	S-adenosylmethionine binding site [chemical binding]; other site
400673003168	Nitronate monooxygenase; Region: NMO; pfam03060
400673003169	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
400673003170	FMN binding site [chemical binding]; other site
400673003171	substrate binding site [chemical binding]; other site
400673003172	putative catalytic residue [active]
400673003173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
400673003174	COQ9; Region: COQ9; pfam08511
400673003175	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
400673003176	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
400673003177	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
400673003178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
400673003179	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
400673003180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673003181	dimer interface [polypeptide binding]; other site
400673003182	conserved gate region; other site
400673003183	putative PBP binding loops; other site
400673003184	ABC-ATPase subunit interface; other site
400673003185	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
400673003186	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
400673003187	Walker A/P-loop; other site
400673003188	ATP binding site [chemical binding]; other site
400673003189	Q-loop/lid; other site
400673003190	ABC transporter signature motif; other site
400673003191	Walker B; other site
400673003192	D-loop; other site
400673003193	H-loop/switch region; other site
400673003194	TOBE domain; Region: TOBE_2; pfam08402
400673003195	short chain dehydrogenase; Provisional; Region: PRK08219
400673003196	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
400673003197	NADP binding site [chemical binding]; other site
400673003198	active site
400673003199	steroid binding site; other site
400673003200	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
400673003201	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
400673003202	active site
400673003203	Zn binding site [ion binding]; other site
400673003204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003205	Coenzyme A binding pocket [chemical binding]; other site
400673003206	probable polyamine oxidase; Region: PLN02268
400673003207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
400673003208	pyruvate decarboxylase; Region: PLN02573
400673003209	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
400673003210	dimer interface [polypeptide binding]; other site
400673003211	PYR/PP interface [polypeptide binding]; other site
400673003212	TPP binding site [chemical binding]; other site
400673003213	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
400673003214	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
400673003215	TPP-binding site [chemical binding]; other site
400673003216	dimer interface [polypeptide binding]; other site
400673003217	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
400673003218	Peptidase family M28; Region: Peptidase_M28; pfam04389
400673003219	metal binding site [ion binding]; metal-binding site
400673003220	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673003221	Putative serine esterase (DUF676); Region: DUF676; pfam05057
400673003222	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673003223	active site
400673003224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003225	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673003226	putative substrate translocation pore; other site
400673003227	acetylornithine deacetylase; Provisional; Region: PRK07522
400673003228	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
400673003229	metal binding site [ion binding]; metal-binding site
400673003230	putative dimer interface [polypeptide binding]; other site
400673003231	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
400673003232	ATP-binding site [chemical binding]; other site
400673003233	Sugar specificity; other site
400673003234	Pyrimidine base specificity; other site
400673003235	7kD viral coat protein; Region: 7kD_coat; pfam02495
400673003236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
400673003237	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
400673003238	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673003239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673003240	metal binding site [ion binding]; metal-binding site
400673003241	active site
400673003242	I-site; other site
400673003243	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673003244	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
400673003245	putative ligand binding pocket/active site [active]
400673003246	putative metal binding site [ion binding]; other site
400673003247	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
400673003248	AMMECR1; Region: AMMECR1; pfam01871
400673003249	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
400673003250	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673003251	FeS/SAM binding site; other site
400673003252	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673003253	Sel1-like repeats; Region: SEL1; smart00671
400673003254	Sel1-like repeats; Region: SEL1; smart00671
400673003255	Sel1-like repeats; Region: SEL1; smart00671
400673003256	Sel1-like repeats; Region: SEL1; smart00671
400673003257	Sel1-like repeats; Region: SEL1; smart00671
400673003258	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673003259	Sel1-like repeats; Region: SEL1; smart00671
400673003260	Sel1-like repeats; Region: SEL1; smart00671
400673003261	Sel1-like repeats; Region: SEL1; smart00671
400673003262	Sel1-like repeats; Region: SEL1; smart00671
400673003263	Sel1-like repeats; Region: SEL1; smart00671
400673003264	Sel1-like repeats; Region: SEL1; smart00671
400673003265	Sel1-like repeats; Region: SEL1; smart00671
400673003266	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
400673003267	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673003268	dimer interface [polypeptide binding]; other site
400673003269	phosphorylation site [posttranslational modification]
400673003270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673003271	ATP binding site [chemical binding]; other site
400673003272	Mg2+ binding site [ion binding]; other site
400673003273	G-X-G motif; other site
400673003274	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
400673003275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673003276	active site
400673003277	phosphorylation site [posttranslational modification]
400673003278	intermolecular recognition site; other site
400673003279	dimerization interface [polypeptide binding]; other site
400673003280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673003281	Walker A motif; other site
400673003282	ATP binding site [chemical binding]; other site
400673003283	Walker B motif; other site
400673003284	arginine finger; other site
400673003285	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
400673003286	AsnC family; Region: AsnC_trans_reg; pfam01037
400673003287	Peptidase family M48; Region: Peptidase_M48; pfam01435
400673003288	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
400673003289	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
400673003290	catalytic motif [active]
400673003291	Zn binding site [ion binding]; other site
400673003292	RibD C-terminal domain; Region: RibD_C; cl17279
400673003293	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
400673003294	Lumazine binding domain; Region: Lum_binding; pfam00677
400673003295	Lumazine binding domain; Region: Lum_binding; pfam00677
400673003296	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
400673003297	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
400673003298	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
400673003299	dimerization interface [polypeptide binding]; other site
400673003300	active site
400673003301	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
400673003302	homopentamer interface [polypeptide binding]; other site
400673003303	active site
400673003304	CTP synthetase; Validated; Region: pyrG; PRK05380
400673003305	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
400673003306	Catalytic site [active]
400673003307	active site
400673003308	UTP binding site [chemical binding]; other site
400673003309	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
400673003310	active site
400673003311	putative oxyanion hole; other site
400673003312	catalytic triad [active]
400673003313	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
400673003314	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
400673003315	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
400673003316	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
400673003317	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
400673003318	Putative exonuclease, RdgC; Region: RdgC; pfam04381
400673003319	K+ potassium transporter; Region: K_trans; pfam02705
400673003320	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
400673003321	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
400673003322	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
400673003323	putative RNA binding site [nucleotide binding]; other site
400673003324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673003325	S-adenosylmethionine binding site [chemical binding]; other site
400673003326	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
400673003327	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
400673003328	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
400673003329	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
400673003330	conserved cys residue [active]
400673003331	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
400673003332	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
400673003333	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
400673003334	metal binding site [ion binding]; metal-binding site
400673003335	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
400673003336	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
400673003337	substrate binding site [chemical binding]; other site
400673003338	glutamase interaction surface [polypeptide binding]; other site
400673003339	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
400673003340	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
400673003341	catalytic residues [active]
400673003342	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
400673003343	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
400673003344	putative active site [active]
400673003345	oxyanion strand; other site
400673003346	catalytic triad [active]
400673003347	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
400673003348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673003349	active site
400673003350	motif I; other site
400673003351	motif II; other site
400673003352	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
400673003353	putative active site pocket [active]
400673003354	4-fold oligomerization interface [polypeptide binding]; other site
400673003355	metal binding residues [ion binding]; metal-binding site
400673003356	3-fold/trimer interface [polypeptide binding]; other site
400673003357	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
400673003358	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
400673003359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673003360	homodimer interface [polypeptide binding]; other site
400673003361	catalytic residue [active]
400673003362	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
400673003363	histidinol dehydrogenase; Region: hisD; TIGR00069
400673003364	NAD binding site [chemical binding]; other site
400673003365	dimerization interface [polypeptide binding]; other site
400673003366	product binding site; other site
400673003367	substrate binding site [chemical binding]; other site
400673003368	zinc binding site [ion binding]; other site
400673003369	catalytic residues [active]
400673003370	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
400673003371	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
400673003372	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
400673003373	Trp repressor protein; Region: Trp_repressor; cl17266
400673003374	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
400673003375	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
400673003376	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
400673003377	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
400673003378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673003379	active site
400673003380	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
400673003381	DNA-binding site [nucleotide binding]; DNA binding site
400673003382	RNA-binding motif; other site
400673003383	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
400673003384	30S subunit binding site; other site
400673003385	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
400673003386	putative deacylase active site [active]
400673003387	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
400673003388	MarR family; Region: MarR_2; pfam12802
400673003389	MarR family; Region: MarR_2; cl17246
400673003390	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
400673003391	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
400673003392	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
400673003393	LysE type translocator; Region: LysE; cl00565
400673003394	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
400673003395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673003396	Coenzyme A binding pocket [chemical binding]; other site
400673003397	Predicted ATPase [General function prediction only]; Region: COG3911
400673003398	AAA domain; Region: AAA_28; pfam13521
400673003399	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673003400	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
400673003401	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
400673003402	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619
400673003403	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
400673003404	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628
400673003405	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
400673003406	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634
400673003407	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
400673003408	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
400673003409	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
400673003410	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
400673003411	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
400673003412	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
400673003413	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
400673003414	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
400673003415	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
400673003416	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
400673003417	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
400673003418	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12701
400673003419	Flagellar L-ring protein; Region: FlgH; pfam02107
400673003420	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
400673003421	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
400673003422	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710
400673003423	Rod binding protein; Region: Rod-binding; cl01626
400673003424	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
400673003425	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715
400673003426	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
400673003427	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
400673003428	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
400673003429	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
400673003430	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
400673003431	active site
400673003432	nucleophile elbow; other site
400673003433	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
400673003434	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
400673003435	transmembrane helices; other site
400673003436	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
400673003437	TrkA-C domain; Region: TrkA_C; pfam02080
400673003438	TrkA-C domain; Region: TrkA_C; pfam02080
400673003439	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
400673003440	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
400673003441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
400673003442	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
400673003443	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
400673003444	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673003445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673003446	Walker A/P-loop; other site
400673003447	ATP binding site [chemical binding]; other site
400673003448	Q-loop/lid; other site
400673003449	ABC transporter signature motif; other site
400673003450	Walker B; other site
400673003451	D-loop; other site
400673003452	H-loop/switch region; other site
400673003453	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
400673003454	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
400673003455	malate dehydrogenase; Provisional; Region: PRK13529
400673003456	Malic enzyme, N-terminal domain; Region: malic; pfam00390
400673003457	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
400673003458	NAD(P) binding site [chemical binding]; other site
400673003459	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
400673003460	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
400673003461	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003462	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
400673003463	Peptidase family M23; Region: Peptidase_M23; pfam01551
400673003464	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
400673003465	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
400673003466	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
400673003467	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
400673003468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
400673003469	DNA binding residues [nucleotide binding]
400673003470	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
400673003471	hypothetical protein; Validated; Region: PRK00110
400673003472	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
400673003473	active site
400673003474	putative DNA-binding cleft [nucleotide binding]; other site
400673003475	dimer interface [polypeptide binding]; other site
400673003476	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
400673003477	RuvA N terminal domain; Region: RuvA_N; pfam01330
400673003478	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
400673003479	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
400673003480	sensor protein QseC; Provisional; Region: PRK10337
400673003481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673003482	dimer interface [polypeptide binding]; other site
400673003483	phosphorylation site [posttranslational modification]
400673003484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673003485	ATP binding site [chemical binding]; other site
400673003486	Mg2+ binding site [ion binding]; other site
400673003487	G-X-G motif; other site
400673003488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673003489	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
400673003490	active site
400673003491	phosphorylation site [posttranslational modification]
400673003492	intermolecular recognition site; other site
400673003493	dimerization interface [polypeptide binding]; other site
400673003494	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
400673003495	DNA binding site [nucleotide binding]
400673003496	intracellular septation protein A; Reviewed; Region: PRK00259
400673003497	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673003498	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673003499	catalytic residue [active]
400673003500	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003501	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003502	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673003503	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
400673003504	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
400673003505	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
400673003506	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
400673003507	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
400673003508	homodimer interface [polypeptide binding]; other site
400673003509	NADP binding site [chemical binding]; other site
400673003510	substrate binding site [chemical binding]; other site
400673003511	FimV N-terminal domain; Region: FimV_core; TIGR03505
400673003512	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
400673003513	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
400673003514	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
400673003515	NADH(P)-binding; Region: NAD_binding_10; pfam13460
400673003516	putative NAD(P) binding site [chemical binding]; other site
400673003517	active site
400673003518	DoxX-like family; Region: DoxX_3; pfam13781
400673003519	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
400673003520	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
400673003521	dimerization interface 3.5A [polypeptide binding]; other site
400673003522	active site
400673003523	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
400673003524	active site
400673003525	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
400673003526	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
400673003527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673003528	catalytic residue [active]
400673003529	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
400673003530	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
400673003531	substrate binding site [chemical binding]; other site
400673003532	active site
400673003533	catalytic residues [active]
400673003534	heterodimer interface [polypeptide binding]; other site
400673003535	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
400673003536	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673003537	active site
400673003538	HIGH motif; other site
400673003539	nucleotide binding site [chemical binding]; other site
400673003540	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
400673003541	KMSKS motif; other site
400673003542	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
400673003543	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
400673003544	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
400673003545	active site
400673003546	HIGH motif; other site
400673003547	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
400673003548	KMSKS motif; other site
400673003549	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
400673003550	tRNA binding surface [nucleotide binding]; other site
400673003551	anticodon binding site; other site
400673003552	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
400673003553	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
400673003554	Sulfatase; Region: Sulfatase; pfam00884
400673003555	type II secretion system protein E; Region: type_II_gspE; TIGR02533
400673003556	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
400673003557	Walker A motif; other site
400673003558	ATP binding site [chemical binding]; other site
400673003559	Walker B motif; other site
400673003560	Sporulation related domain; Region: SPOR; pfam05036
400673003561	type II secretion system protein D; Region: type_II_gspD; TIGR02517
400673003562	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
400673003563	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
400673003564	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
400673003565	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
400673003566	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
400673003567	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
400673003568	Cache domain; Region: Cache_1; pfam02743
400673003569	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
400673003570	cyclase homology domain; Region: CHD; cd07302
400673003571	nucleotidyl binding site; other site
400673003572	metal binding site [ion binding]; metal-binding site
400673003573	dimer interface [polypeptide binding]; other site
400673003574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003575	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
400673003576	putative substrate translocation pore; other site
400673003577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003578	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673003579	putative substrate translocation pore; other site
400673003580	IucA / IucC family; Region: IucA_IucC; pfam04183
400673003581	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
400673003582	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
400673003583	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
400673003584	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
400673003585	Sporulation related domain; Region: SPOR; pfam05036
400673003586	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
400673003587	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
400673003588	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
400673003589	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
400673003590	protein binding site [polypeptide binding]; other site
400673003591	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
400673003592	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
400673003593	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
400673003594	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
400673003595	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
400673003596	RNA binding surface [nucleotide binding]; other site
400673003597	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
400673003598	active site
400673003599	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
400673003600	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
400673003601	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673003602	FeS/SAM binding site; other site
400673003603	TRAM domain; Region: TRAM; pfam01938
400673003604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003605	putative substrate translocation pore; other site
400673003606	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673003607	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673003608	Flagellar protein FliS; Region: FliS; cl00654
400673003609	flagellar capping protein; Provisional; Region: PRK12765
400673003610	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
400673003611	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
400673003612	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
400673003613	flagellin; Provisional; Region: PRK12806
400673003614	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
400673003615	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
400673003616	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
400673003617	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
400673003618	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
400673003619	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673003620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
400673003621	Sporulation related domain; Region: SPOR; pfam05036
400673003622	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
400673003623	Colicin V production protein; Region: Colicin_V; pfam02674
400673003624	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
400673003625	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
400673003626	active site
400673003627	(T/H)XGH motif; other site
400673003628	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
400673003629	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
400673003630	Lipopolysaccharide-assembly; Region: LptE; cl01125
400673003631	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
400673003632	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
400673003633	HIGH motif; other site
400673003634	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
400673003635	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673003636	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673003637	active site
400673003638	KMSKS motif; other site
400673003639	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
400673003640	tRNA binding surface [nucleotide binding]; other site
400673003641	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
400673003642	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
400673003643	putative active site [active]
400673003644	catalytic triad [active]
400673003645	putative dimer interface [polypeptide binding]; other site
400673003646	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
400673003647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673003648	aldehyde dehydrogenase family 7 member; Region: PLN02315
400673003649	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
400673003650	tetrameric interface [polypeptide binding]; other site
400673003651	NAD binding site [chemical binding]; other site
400673003652	catalytic residues [active]
400673003653	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
400673003654	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
400673003655	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
400673003656	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
400673003657	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
400673003658	substrate binding site [chemical binding]; other site
400673003659	oxyanion hole (OAH) forming residues; other site
400673003660	trimer interface [polypeptide binding]; other site
400673003661	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
400673003662	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
400673003663	dimer interface [polypeptide binding]; other site
400673003664	active site
400673003665	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673003666	Sel1-like repeats; Region: SEL1; smart00671
400673003667	Sel1-like repeats; Region: SEL1; smart00671
400673003668	Sel1-like repeats; Region: SEL1; smart00671
400673003669	Sel1-like repeats; Region: SEL1; smart00671
400673003670	Sel1-like repeats; Region: SEL1; smart00671
400673003671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673003672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673003673	metal binding site [ion binding]; metal-binding site
400673003674	active site
400673003675	I-site; other site
400673003676	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673003677	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
400673003678	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
400673003679	type II secretion system protein J; Region: gspJ; TIGR01711
400673003680	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
400673003681	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
400673003682	Type II transport protein GspH; Region: GspH; pfam12019
400673003683	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
400673003684	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
400673003685	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
400673003686	type II secretion system protein F; Region: GspF; TIGR02120
400673003687	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
400673003688	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
400673003689	glutamine synthetase; Provisional; Region: glnA; PRK09469
400673003690	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
400673003691	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
400673003692	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
400673003693	hypothetical protein; Validated; Region: PRK02101
400673003694	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
400673003695	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
400673003696	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673003697	catalytic residue [active]
400673003698	heat shock protein 90; Provisional; Region: PRK05218
400673003699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673003700	ATP binding site [chemical binding]; other site
400673003701	Mg2+ binding site [ion binding]; other site
400673003702	G-X-G motif; other site
400673003703	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
400673003704	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
400673003705	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
400673003706	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
400673003707	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
400673003708	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
400673003709	RNA/DNA hybrid binding site [nucleotide binding]; other site
400673003710	active site
400673003711	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
400673003712	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
400673003713	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
400673003714	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
400673003715	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
400673003716	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
400673003717	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
400673003718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003719	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
400673003720	urocanate hydratase; Provisional; Region: PRK05414
400673003721	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
400673003722	active sites [active]
400673003723	tetramer interface [polypeptide binding]; other site
400673003724	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
400673003725	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
400673003726	NAD(P) binding site [chemical binding]; other site
400673003727	catalytic residues [active]
400673003728	short chain dehydrogenase; Provisional; Region: PRK08278
400673003729	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
400673003730	NAD(P) binding site [chemical binding]; other site
400673003731	homodimer interface [polypeptide binding]; other site
400673003732	active site
400673003733	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
400673003734	RNA/DNA hybrid binding site [nucleotide binding]; other site
400673003735	active site
400673003736	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
400673003737	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
400673003738	active site
400673003739	catalytic site [active]
400673003740	substrate binding site [chemical binding]; other site
400673003741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
400673003742	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673003743	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
400673003744	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
400673003745	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
400673003746	Ligand Binding Site [chemical binding]; other site
400673003747	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
400673003748	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
400673003749	putative phosphate acyltransferase; Provisional; Region: PRK05331
400673003750	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
400673003751	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
400673003752	dimer interface [polypeptide binding]; other site
400673003753	active site
400673003754	CoA binding pocket [chemical binding]; other site
400673003755	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
400673003756	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
400673003757	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
400673003758	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
400673003759	NAD(P) binding site [chemical binding]; other site
400673003760	homotetramer interface [polypeptide binding]; other site
400673003761	homodimer interface [polypeptide binding]; other site
400673003762	active site
400673003763	acyl carrier protein; Provisional; Region: acpP; PRK00982
400673003764	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
400673003765	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
400673003766	dimer interface [polypeptide binding]; other site
400673003767	active site
400673003768	YceG-like family; Region: YceG; pfam02618
400673003769	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
400673003770	dimerization interface [polypeptide binding]; other site
400673003771	thymidylate kinase; Validated; Region: tmk; PRK00698
400673003772	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
400673003773	TMP-binding site; other site
400673003774	ATP-binding site [chemical binding]; other site
400673003775	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
400673003776	DNA polymerase III subunit delta'; Validated; Region: PRK08485
400673003777	PilZ domain; Region: PilZ; cl01260
400673003778	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
400673003779	active site
400673003780	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
400673003781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673003782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003783	putative substrate translocation pore; other site
400673003784	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
400673003785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003786	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
400673003787	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
400673003788	Ligand binding site; other site
400673003789	Putative Catalytic site; other site
400673003790	DXD motif; other site
400673003791	GtrA-like protein; Region: GtrA; pfam04138
400673003792	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
400673003793	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
400673003794	Phosphotransferase enzyme family; Region: APH; pfam01636
400673003795	active site
400673003796	ATP binding site [chemical binding]; other site
400673003797	substrate binding site [chemical binding]; other site
400673003798	dimer interface [polypeptide binding]; other site
400673003799	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
400673003800	active site
400673003801	catalytic site [active]
400673003802	substrate binding site [chemical binding]; other site
400673003803	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
400673003804	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673003805	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673003806	catalytic residue [active]
400673003807	adenylate kinase; Reviewed; Region: adk; PRK00279
400673003808	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
400673003809	AMP-binding site [chemical binding]; other site
400673003810	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
400673003811	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
400673003812	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
400673003813	catalytic residues [active]
400673003814	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
400673003815	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
400673003816	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
400673003817	N- and C-terminal domain interface [polypeptide binding]; other site
400673003818	active site
400673003819	MgATP binding site [chemical binding]; other site
400673003820	catalytic site [active]
400673003821	metal binding site [ion binding]; metal-binding site
400673003822	glycerol binding site [chemical binding]; other site
400673003823	homotetramer interface [polypeptide binding]; other site
400673003824	homodimer interface [polypeptide binding]; other site
400673003825	FBP binding site [chemical binding]; other site
400673003826	protein IIAGlc interface [polypeptide binding]; other site
400673003827	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
400673003828	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
400673003829	dimer interface [polypeptide binding]; other site
400673003830	active site
400673003831	citrylCoA binding site [chemical binding]; other site
400673003832	NADH binding [chemical binding]; other site
400673003833	cationic pore residues; other site
400673003834	oxalacetate/citrate binding site [chemical binding]; other site
400673003835	coenzyme A binding site [chemical binding]; other site
400673003836	catalytic triad [active]
400673003837	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
400673003838	DNA gyrase subunit A; Validated; Region: PRK05560
400673003839	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
400673003840	CAP-like domain; other site
400673003841	active site
400673003842	primary dimer interface [polypeptide binding]; other site
400673003843	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003844	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003845	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003846	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003847	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003848	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
400673003849	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
400673003850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673003851	catalytic residue [active]
400673003852	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
400673003853	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
400673003854	hinge; other site
400673003855	active site
400673003856	cytidylate kinase; Provisional; Region: cmk; PRK00023
400673003857	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
400673003858	CMP-binding site; other site
400673003859	The sites determining sugar specificity; other site
400673003860	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
400673003861	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
400673003862	RNA binding site [nucleotide binding]; other site
400673003863	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
400673003864	RNA binding site [nucleotide binding]; other site
400673003865	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
400673003866	RNA binding site [nucleotide binding]; other site
400673003867	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
400673003868	RNA binding site [nucleotide binding]; other site
400673003869	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
400673003870	RNA binding site [nucleotide binding]; other site
400673003871	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
400673003872	RNA binding site [nucleotide binding]; other site
400673003873	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
400673003874	tetratricopeptide repeat protein; Provisional; Region: PRK11788
400673003875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673003876	TPR motif; other site
400673003877	binding surface
400673003878	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
400673003879	binding surface
400673003880	TPR motif; other site
400673003881	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
400673003882	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
400673003883	inhibitor-cofactor binding pocket; inhibition site
400673003884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673003885	catalytic residue [active]
400673003886	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
400673003887	active site
400673003888	dimer interface [polypeptide binding]; other site
400673003889	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
400673003890	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
400673003891	active site
400673003892	nucleophile elbow; other site
400673003893	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
400673003894	classical (c) SDRs; Region: SDR_c; cd05233
400673003895	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
400673003896	NAD(P) binding site [chemical binding]; other site
400673003897	active site
400673003898	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
400673003899	Chorismate lyase; Region: Chor_lyase; cl01230
400673003900	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
400673003901	UbiA prenyltransferase family; Region: UbiA; pfam01040
400673003902	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
400673003903	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
400673003904	FAD binding domain; Region: FAD_binding_4; pfam01565
400673003905	Berberine and berberine like; Region: BBE; pfam08031
400673003906	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
400673003907	intersubunit interface [polypeptide binding]; other site
400673003908	active site
400673003909	catalytic residue [active]
400673003910	purine nucleoside phosphorylase; Provisional; Region: PRK08202
400673003911	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
400673003912	active site
400673003913	catalytic motif [active]
400673003914	Zn binding site [ion binding]; other site
400673003915	two-component sensor protein; Provisional; Region: cpxA; PRK09470
400673003916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
400673003917	dimerization interface [polypeptide binding]; other site
400673003918	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673003919	dimer interface [polypeptide binding]; other site
400673003920	phosphorylation site [posttranslational modification]
400673003921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673003922	ATP binding site [chemical binding]; other site
400673003923	Mg2+ binding site [ion binding]; other site
400673003924	G-X-G motif; other site
400673003925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673003926	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
400673003927	active site
400673003928	phosphorylation site [posttranslational modification]
400673003929	intermolecular recognition site; other site
400673003930	dimerization interface [polypeptide binding]; other site
400673003931	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
400673003932	DNA binding site [nucleotide binding]
400673003933	FOG: CBS domain [General function prediction only]; Region: COG0517
400673003934	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
400673003935	Transporter associated domain; Region: CorC_HlyC; smart01091
400673003936	metal-binding heat shock protein; Provisional; Region: PRK00016
400673003937	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
400673003938	PhoH-like protein; Region: PhoH; pfam02562
400673003939	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
400673003940	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
400673003941	active site
400673003942	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
400673003943	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
400673003944	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
400673003945	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
400673003946	active site
400673003947	HIGH motif; other site
400673003948	dimer interface [polypeptide binding]; other site
400673003949	KMSKS motif; other site
400673003950	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
400673003951	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
400673003952	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
400673003953	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
400673003954	RNA binding surface [nucleotide binding]; other site
400673003955	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
400673003956	probable active site [active]
400673003957	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
400673003958	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
400673003959	putative ligand binding site [chemical binding]; other site
400673003960	PAS domain S-box; Region: sensory_box; TIGR00229
400673003961	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673003962	putative active site [active]
400673003963	heme pocket [chemical binding]; other site
400673003964	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673003965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673003966	metal binding site [ion binding]; metal-binding site
400673003967	active site
400673003968	I-site; other site
400673003969	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673003970	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
400673003971	substrate binding site [chemical binding]; other site
400673003972	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673003973	putative transporter; Provisional; Region: PRK10504
400673003974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673003975	putative substrate translocation pore; other site
400673003976	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
400673003977	TRAM domain; Region: TRAM; pfam01938
400673003978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673003979	S-adenosylmethionine binding site [chemical binding]; other site
400673003980	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
400673003981	HD domain; Region: HD_4; pfam13328
400673003982	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
400673003983	synthetase active site [active]
400673003984	NTP binding site [chemical binding]; other site
400673003985	metal binding site [ion binding]; metal-binding site
400673003986	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
400673003987	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
400673003988	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
400673003989	aminotransferase; Validated; Region: PRK08175
400673003990	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
400673003991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673003992	homodimer interface [polypeptide binding]; other site
400673003993	catalytic residue [active]
400673003994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
400673003995	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
400673003996	DHH family; Region: DHH; pfam01368
400673003997	DHHA1 domain; Region: DHHA1; pfam02272
400673003998	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
400673003999	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
400673004000	FMN binding site [chemical binding]; other site
400673004001	active site
400673004002	catalytic residues [active]
400673004003	substrate binding site [chemical binding]; other site
400673004004	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104
400673004005	DEAD/DEAH box helicase; Region: DEAD; pfam00270
400673004006	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
400673004007	SEC-C motif; Region: SEC-C; pfam02810
400673004008	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
400673004009	active site
400673004010	8-oxo-dGMP binding site [chemical binding]; other site
400673004011	nudix motif; other site
400673004012	metal binding site [ion binding]; metal-binding site
400673004013	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
400673004014	hypothetical protein; Provisional; Region: PRK05287
400673004015	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
400673004016	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
400673004017	CoA-binding site [chemical binding]; other site
400673004018	ATP-binding [chemical binding]; other site
400673004019	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673004020	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
400673004021	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
400673004022	inhibitor-cofactor binding pocket; inhibition site
400673004023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673004024	catalytic residue [active]
400673004025	biotin synthase; Region: bioB; TIGR00433
400673004026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673004027	FeS/SAM binding site; other site
400673004028	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
400673004029	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
400673004030	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
400673004031	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673004032	catalytic residue [active]
400673004033	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
400673004034	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
400673004035	AAA domain; Region: AAA_26; pfam13500
400673004036	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
400673004037	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
400673004038	Uncharacterized conserved protein [Function unknown]; Region: COG2928
400673004039	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
400673004040	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
400673004041	dimer interface [polypeptide binding]; other site
400673004042	anticodon binding site; other site
400673004043	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
400673004044	homodimer interface [polypeptide binding]; other site
400673004045	motif 1; other site
400673004046	active site
400673004047	motif 2; other site
400673004048	GAD domain; Region: GAD; pfam02938
400673004049	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
400673004050	motif 3; other site
400673004051	CENP-A-nucleosome distal (CAD) centromere subunit; Region: CENP-Q; pfam13094
400673004052	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
400673004053	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
400673004054	Mechanosensitive ion channel; Region: MS_channel; pfam00924
400673004055	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
400673004056	putative DNA-binding cleft [nucleotide binding]; other site
400673004057	putative DNA clevage site; other site
400673004058	molecular lever; other site
400673004059	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
400673004060	Catalytic domain of Protein Kinases; Region: PKc; cd00180
400673004061	active site
400673004062	ATP binding site [chemical binding]; other site
400673004063	substrate binding site [chemical binding]; other site
400673004064	activation loop (A-loop); other site
400673004065	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
400673004066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
400673004067	putative DNA binding site [nucleotide binding]; other site
400673004068	putative Zn2+ binding site [ion binding]; other site
400673004069	AsnC family; Region: AsnC_trans_reg; pfam01037
400673004070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673004071	Coenzyme A binding pocket [chemical binding]; other site
400673004072	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
400673004073	GAF domain; Region: GAF; pfam01590
400673004074	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
400673004075	cyclase homology domain; Region: CHD; cd07302
400673004076	nucleotidyl binding site; other site
400673004077	metal binding site [ion binding]; metal-binding site
400673004078	dimer interface [polypeptide binding]; other site
400673004079	Pathogenicity locus; Region: Cdd1; pfam11731
400673004080	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
400673004081	Phosphotransferase enzyme family; Region: APH; pfam01636
400673004082	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673004083	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
400673004084	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
400673004085	putative active site pocket [active]
400673004086	dimerization interface [polypeptide binding]; other site
400673004087	putative catalytic residue [active]
400673004088	Dot/Icm substrate protein; Region: SidE; pfam12252
400673004089	aminopeptidase N; Provisional; Region: pepN; PRK14015
400673004090	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
400673004091	Zn binding site [ion binding]; other site
400673004092	C factor cell-cell signaling protein; Provisional; Region: PRK09009
400673004093	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673004094	NAD(P) binding site [chemical binding]; other site
400673004095	active site
400673004096	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
400673004097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
400673004098	Coenzyme A binding pocket [chemical binding]; other site
400673004099	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
400673004100	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673004101	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
400673004102	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
400673004103	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673004104	E3 interaction surface; other site
400673004105	lipoyl attachment site [posttranslational modification]; other site
400673004106	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673004107	E3 interaction surface; other site
400673004108	lipoyl attachment site [posttranslational modification]; other site
400673004109	e3 binding domain; Region: E3_binding; pfam02817
400673004110	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
400673004111	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
400673004112	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
400673004113	dimer interface [polypeptide binding]; other site
400673004114	TPP-binding site [chemical binding]; other site
400673004115	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
400673004116	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
400673004117	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
400673004118	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
400673004119	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
400673004120	Sporulation related domain; Region: SPOR; pfam05036
400673004121	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
400673004122	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
400673004123	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
400673004124	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
400673004125	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
400673004126	homodimer interface [polypeptide binding]; other site
400673004127	substrate-cofactor binding pocket; other site
400673004128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673004129	catalytic residue [active]
400673004130	Protein of unknown function (DUF493); Region: DUF493; pfam04359
400673004131	lipoate-protein ligase B; Provisional; Region: PRK14342
400673004132	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
400673004133	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
400673004134	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
400673004135	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
400673004136	active site
400673004137	LssY C-terminus; Region: LssY_C; pfam14067
400673004138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
400673004139	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
400673004140	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
400673004141	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673004142	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
400673004143	Walker A/P-loop; other site
400673004144	ATP binding site [chemical binding]; other site
400673004145	Q-loop/lid; other site
400673004146	ABC transporter signature motif; other site
400673004147	Walker B; other site
400673004148	D-loop; other site
400673004149	H-loop/switch region; other site
400673004150	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
400673004151	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673004152	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673004153	PAS domain S-box; Region: sensory_box; TIGR00229
400673004154	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673004155	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673004156	metal binding site [ion binding]; metal-binding site
400673004157	active site
400673004158	I-site; other site
400673004159	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673004160	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673004161	active site
400673004162	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
400673004163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673004164	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
400673004165	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
400673004166	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
400673004167	Walker A motif; other site
400673004168	ATP binding site [chemical binding]; other site
400673004169	Walker B motif; other site
400673004170	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
400673004171	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
400673004172	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
400673004173	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
400673004174	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
400673004175	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
400673004176	CAAX protease self-immunity; Region: Abi; pfam02517
400673004177	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673004178	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673004179	ligand binding site [chemical binding]; other site
400673004180	PEP synthetase regulatory protein; Provisional; Region: PRK05339
400673004181	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
400673004182	2-methylcitrate dehydratase; Region: prpD; TIGR02330
400673004183	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
400673004184	dimer interface [polypeptide binding]; other site
400673004185	Citrate synthase; Region: Citrate_synt; pfam00285
400673004186	active site
400673004187	citrylCoA binding site [chemical binding]; other site
400673004188	oxalacetate/citrate binding site [chemical binding]; other site
400673004189	coenzyme A binding site [chemical binding]; other site
400673004190	catalytic triad [active]
400673004191	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
400673004192	Uncharacterized conserved protein [Function unknown]; Region: COG4121
400673004193	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
400673004194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
400673004195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004196	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
400673004197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004198	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
400673004199	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
400673004200	inhibitor-cofactor binding pocket; inhibition site
400673004201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673004202	catalytic residue [active]
400673004203	Rubredoxin [Energy production and conversion]; Region: COG1773
400673004204	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
400673004205	iron binding site [ion binding]; other site
400673004206	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
400673004207	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
400673004208	poly(A) polymerase; Region: pcnB; TIGR01942
400673004209	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
400673004210	active site
400673004211	NTP binding site [chemical binding]; other site
400673004212	metal binding triad [ion binding]; metal-binding site
400673004213	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
400673004214	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
400673004215	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
400673004216	catalytic center binding site [active]
400673004217	ATP binding site [chemical binding]; other site
400673004218	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
400673004219	Ligand Binding Site [chemical binding]; other site
400673004220	GTP-binding protein Der; Reviewed; Region: PRK00093
400673004221	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
400673004222	G1 box; other site
400673004223	GTP/Mg2+ binding site [chemical binding]; other site
400673004224	Switch I region; other site
400673004225	G2 box; other site
400673004226	Switch II region; other site
400673004227	G3 box; other site
400673004228	G4 box; other site
400673004229	G5 box; other site
400673004230	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
400673004231	G1 box; other site
400673004232	GTP/Mg2+ binding site [chemical binding]; other site
400673004233	Switch I region; other site
400673004234	G2 box; other site
400673004235	G3 box; other site
400673004236	Switch II region; other site
400673004237	G4 box; other site
400673004238	G5 box; other site
400673004239	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
400673004240	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
400673004241	Trp docking motif [polypeptide binding]; other site
400673004242	active site
400673004243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
400673004244	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
400673004245	histidyl-tRNA synthetase; Region: hisS; TIGR00442
400673004246	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
400673004247	dimer interface [polypeptide binding]; other site
400673004248	motif 1; other site
400673004249	active site
400673004250	motif 2; other site
400673004251	motif 3; other site
400673004252	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
400673004253	anticodon binding site; other site
400673004254	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
400673004255	Helix-turn-helix domain; Region: HTH_25; pfam13413
400673004256	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
400673004257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673004258	binding surface
400673004259	TPR motif; other site
400673004260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673004261	binding surface
400673004262	TPR motif; other site
400673004263	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
400673004264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673004265	FeS/SAM binding site; other site
400673004266	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
400673004267	active site
400673004268	multimer interface [polypeptide binding]; other site
400673004269	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
400673004270	active site
400673004271	dinuclear metal binding site [ion binding]; other site
400673004272	dimerization interface [polypeptide binding]; other site
400673004273	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
400673004274	putative active site [active]
400673004275	putative metal binding site [ion binding]; other site
400673004276	septum formation inhibitor; Reviewed; Region: minC; PRK00339
400673004277	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
400673004278	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
400673004279	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
400673004280	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
400673004281	acyl-activating enzyme (AAE) consensus motif; other site
400673004282	putative AMP binding site [chemical binding]; other site
400673004283	putative active site [active]
400673004284	putative CoA binding site [chemical binding]; other site
400673004285	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
400673004286	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
400673004287	substrate binding pocket [chemical binding]; other site
400673004288	membrane-bound complex binding site; other site
400673004289	hinge residues; other site
400673004290	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
400673004291	putative active site [active]
400673004292	putative CoA binding site [chemical binding]; other site
400673004293	nudix motif; other site
400673004294	metal binding site [ion binding]; metal-binding site
400673004295	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
400673004296	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
400673004297	chorismate binding enzyme; Region: Chorismate_bind; cl10555
400673004298	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
400673004299	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
400673004300	TPP-binding site [chemical binding]; other site
400673004301	tetramer interface [polypeptide binding]; other site
400673004302	heterodimer interface [polypeptide binding]; other site
400673004303	phosphorylation loop region [posttranslational modification]
400673004304	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
400673004305	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
400673004306	alpha subunit interface [polypeptide binding]; other site
400673004307	TPP binding site [chemical binding]; other site
400673004308	heterodimer interface [polypeptide binding]; other site
400673004309	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
400673004310	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
400673004311	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673004312	E3 interaction surface; other site
400673004313	lipoyl attachment site [posttranslational modification]; other site
400673004314	e3 binding domain; Region: E3_binding; pfam02817
400673004315	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
400673004316	Mechanosensitive ion channel; Region: MS_channel; pfam00924
400673004317	Uncharacterized conserved protein [Function unknown]; Region: COG0398
400673004318	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
400673004319	mercuric reductase; Validated; Region: PRK06370
400673004320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673004321	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
400673004322	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
400673004323	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673004324	active site
400673004325	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434
400673004326	NMT1/THI5 like; Region: NMT1; pfam09084
400673004327	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
400673004328	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
400673004329	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
400673004330	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
400673004331	thiS-thiF/thiG interaction site; other site
400673004332	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
400673004333	ThiS interaction site; other site
400673004334	putative active site [active]
400673004335	tetramer interface [polypeptide binding]; other site
400673004336	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
400673004337	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
400673004338	dimer interface [polypeptide binding]; other site
400673004339	substrate binding site [chemical binding]; other site
400673004340	ATP binding site [chemical binding]; other site
400673004341	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
400673004342	thiamine phosphate binding site [chemical binding]; other site
400673004343	active site
400673004344	pyrophosphate binding site [ion binding]; other site
400673004345	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
400673004346	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
400673004347	ATP binding site [chemical binding]; other site
400673004348	substrate interface [chemical binding]; other site
400673004349	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
400673004350	active site residue [active]
400673004351	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
400673004352	active site
400673004353	Zn binding site [ion binding]; other site
400673004354	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
400673004355	TolB amino-terminal domain; Region: TolB_N; pfam04052
400673004356	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
400673004357	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
400673004358	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
400673004359	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
400673004360	TolA protein; Region: tolA_full; TIGR02794
400673004361	TolA protein; Region: tolA_full; TIGR02794
400673004362	TonB C terminal; Region: TonB_2; pfam13103
400673004363	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
400673004364	TolR protein; Region: tolR; TIGR02801
400673004365	TolQ protein; Region: tolQ; TIGR02796
400673004366	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
400673004367	active site
400673004368	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
400673004369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673004370	Walker A motif; other site
400673004371	ATP binding site [chemical binding]; other site
400673004372	Walker B motif; other site
400673004373	arginine finger; other site
400673004374	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
400673004375	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
400673004376	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
400673004377	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
400673004378	DNA binding residues [nucleotide binding]
400673004379	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
400673004380	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
400673004381	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
400673004382	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
400673004383	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
400673004384	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
400673004385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
400673004386	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673004387	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
400673004388	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
400673004389	NAD(P) binding site [chemical binding]; other site
400673004390	catalytic residues [active]
400673004391	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
400673004392	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
400673004393	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
400673004394	putative catalytic residue [active]
400673004395	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
400673004396	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
400673004397	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
400673004398	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
400673004399	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
400673004400	Global regulator protein family; Region: CsrA; pfam02599
400673004401	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
400673004402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
400673004403	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673004404	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
400673004405	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
400673004406	substrate binding site [chemical binding]; other site
400673004407	oxyanion hole (OAH) forming residues; other site
400673004408	trimer interface [polypeptide binding]; other site
400673004409	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
400673004410	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
400673004411	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
400673004412	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
400673004413	dimer interface [polypeptide binding]; other site
400673004414	active site
400673004415	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
400673004416	Leucine-rich repeats; other site
400673004417	Substrate binding site [chemical binding]; other site
400673004418	RES domain; Region: RES; smart00953
400673004419	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
400673004420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673004421	S-adenosylmethionine binding site [chemical binding]; other site
400673004422	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
400673004423	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
400673004424	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
400673004425	nudix motif; other site
400673004426	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
400673004427	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
400673004428	putative catalytic cysteine [active]
400673004429	gamma-glutamyl kinase; Provisional; Region: PRK05429
400673004430	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
400673004431	nucleotide binding site [chemical binding]; other site
400673004432	homotetrameric interface [polypeptide binding]; other site
400673004433	putative phosphate binding site [ion binding]; other site
400673004434	putative allosteric binding site; other site
400673004435	PUA domain; Region: PUA; pfam01472
400673004436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673004437	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
400673004438	Coenzyme A binding pocket [chemical binding]; other site
400673004439	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
400673004440	DNA binding residues [nucleotide binding]
400673004441	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
400673004442	dimer interface [polypeptide binding]; other site
400673004443	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
400673004444	active site
400673004445	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
400673004446	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
400673004447	DNA binding residues [nucleotide binding]
400673004448	dimer interface [polypeptide binding]; other site
400673004449	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
400673004450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673004451	Coenzyme A binding pocket [chemical binding]; other site
400673004452	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
400673004453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673004454	Coenzyme A binding pocket [chemical binding]; other site
400673004455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673004456	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
400673004457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673004458	Walker A/P-loop; other site
400673004459	ATP binding site [chemical binding]; other site
400673004460	Q-loop/lid; other site
400673004461	ABC transporter signature motif; other site
400673004462	Walker B; other site
400673004463	D-loop; other site
400673004464	H-loop/switch region; other site
400673004465	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
400673004466	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673004467	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
400673004468	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673004469	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
400673004470	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
400673004471	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
400673004472	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
400673004473	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
400673004474	Penicillinase repressor; Region: Pencillinase_R; pfam03965
400673004475	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
400673004476	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
400673004477	Permutation of conserved domain; other site
400673004478	active site
400673004479	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
400673004480	putative hydrolase; Provisional; Region: PRK10985
400673004481	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673004482	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673004483	Soluble P-type ATPase [General function prediction only]; Region: COG4087
400673004484	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
400673004485	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
400673004486	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
400673004487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673004488	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
400673004489	NAD(P) binding site [chemical binding]; other site
400673004490	active site
400673004491	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
400673004492	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
400673004493	dimer interface [polypeptide binding]; other site
400673004494	active site
400673004495	CoA binding pocket [chemical binding]; other site
400673004496	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
400673004497	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
400673004498	putative ADP-binding pocket [chemical binding]; other site
400673004499	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
400673004500	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
400673004501	FAD binding domain; Region: FAD_binding_4; pfam01565
400673004502	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
400673004503	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
400673004504	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
400673004505	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
400673004506	active site
400673004507	catalytic site [active]
400673004508	tetramer interface [polypeptide binding]; other site
400673004509	enterobactin exporter EntS; Provisional; Region: PRK10489
400673004510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004511	putative substrate translocation pore; other site
400673004512	Predicted membrane protein [Function unknown]; Region: COG2119
400673004513	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
400673004514	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
400673004515	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
400673004516	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
400673004517	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
400673004518	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
400673004519	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
400673004520	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673004521	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
400673004522	threonine synthase; Validated; Region: PRK09225
400673004523	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673004524	catalytic residue [active]
400673004525	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
400673004526	Dot/Icm substrate protein; Region: SidE; pfam12252
400673004527	YceI-like domain; Region: YceI; pfam04264
400673004528	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
400673004529	YceI-like domain; Region: YceI; smart00867
400673004530	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
400673004531	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
400673004532	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
400673004533	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
400673004534	PYR/PP interface [polypeptide binding]; other site
400673004535	dimer interface [polypeptide binding]; other site
400673004536	TPP binding site [chemical binding]; other site
400673004537	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
400673004538	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
400673004539	TPP-binding site; other site
400673004540	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
400673004541	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
400673004542	substrate binding site [chemical binding]; other site
400673004543	ATP binding site [chemical binding]; other site
400673004544	KduI/IolB family; Region: KduI; pfam04962
400673004545	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
400673004546	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
400673004547	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
400673004548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004549	putative substrate translocation pore; other site
400673004550	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
400673004551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004552	Tetratricopeptide repeat; Region: TPR_12; pfam13424
400673004553	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
400673004554	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
400673004555	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
400673004556	active site
400673004557	Zn binding site [ion binding]; other site
400673004558	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673004559	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
400673004560	Amidinotransferase; Region: Amidinotransf; cl12043
400673004561	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
400673004562	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
400673004563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
400673004564	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673004565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673004566	putative substrate translocation pore; other site
400673004567	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
400673004568	Transglycosylase; Region: Transgly; pfam00912
400673004569	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
400673004570	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
400673004571	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
400673004572	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
400673004573	MG2 domain; Region: A2M_N; pfam01835
400673004574	Alpha-2-macroglobulin family; Region: A2M; pfam00207
400673004575	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
400673004576	surface patch; other site
400673004577	thioester region; other site
400673004578	specificity defining residues; other site
400673004579	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
400673004580	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
400673004581	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
400673004582	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
400673004583	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
400673004584	active site
400673004585	catalytic site [active]
400673004586	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
400673004587	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
400673004588	active site
400673004589	substrate binding site [chemical binding]; other site
400673004590	cosubstrate binding site; other site
400673004591	catalytic site [active]
400673004592	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
400673004593	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
400673004594	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673004595	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
400673004596	amidophosphoribosyltransferase; Provisional; Region: PRK09246
400673004597	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
400673004598	active site
400673004599	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673004600	active site
400673004601	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
400673004602	ATP binding site [chemical binding]; other site
400673004603	active site
400673004604	substrate binding site [chemical binding]; other site
400673004605	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
400673004606	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
400673004607	putative active site [active]
400673004608	catalytic triad [active]
400673004609	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
400673004610	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
400673004611	dimerization interface [polypeptide binding]; other site
400673004612	putative ATP binding site [chemical binding]; other site
400673004613	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
400673004614	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
400673004615	dimerization interface [polypeptide binding]; other site
400673004616	ATP binding site [chemical binding]; other site
400673004617	Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824
400673004618	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
400673004619	dimerization interface [polypeptide binding]; other site
400673004620	ATP binding site [chemical binding]; other site
400673004621	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
400673004622	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
400673004623	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
400673004624	DsbD alpha interface [polypeptide binding]; other site
400673004625	catalytic residues [active]
400673004626	short chain dehydrogenase; Provisional; Region: PRK05993
400673004627	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
400673004628	NADP binding site [chemical binding]; other site
400673004629	active site
400673004630	steroid binding site; other site
400673004631	D123; Region: D123; pfam07065
400673004632	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
400673004633	aconitate hydratase; Validated; Region: PRK09277
400673004634	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
400673004635	substrate binding site [chemical binding]; other site
400673004636	ligand binding site [chemical binding]; other site
400673004637	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
400673004638	substrate binding site [chemical binding]; other site
400673004639	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
400673004640	DDE superfamily endonuclease; Region: DDE_3; pfam13358
400673004641	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
400673004642	Proline dehydrogenase; Region: Pro_dh; pfam01619
400673004643	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
400673004644	Glutamate binding site [chemical binding]; other site
400673004645	NAD binding site [chemical binding]; other site
400673004646	catalytic residues [active]
400673004647	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
400673004648	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
400673004649	ProQ/FINO family; Region: ProQ; pfam04352
400673004650	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
400673004651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673004652	S-adenosylmethionine binding site [chemical binding]; other site
400673004653	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
400673004654	ligand binding site [chemical binding]; other site
400673004655	active site
400673004656	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
400673004657	cell division protein MukB; Provisional; Region: mukB; PRK04863
400673004658	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
400673004659	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
400673004660	active site
400673004661	DNA binding site [nucleotide binding]
400673004662	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
400673004663	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
400673004664	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
400673004665	Catalytic site [active]
400673004666	hypothetical protein; Provisional; Region: PRK07338
400673004667	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
400673004668	metal binding site [ion binding]; metal-binding site
400673004669	dimer interface [polypeptide binding]; other site
400673004670	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
400673004671	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
400673004672	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
400673004673	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
400673004674	NAD(P) binding site [chemical binding]; other site
400673004675	catalytic residues [active]
400673004676	succinylarginine dihydrolase; Provisional; Region: PRK13281
400673004677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673004678	Cytochrome c; Region: Cytochrom_C; cl11414
400673004679	ribosome recycling factor; Reviewed; Region: frr; PRK00083
400673004680	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
400673004681	hinge region; other site
400673004682	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
400673004683	putative nucleotide binding site [chemical binding]; other site
400673004684	uridine monophosphate binding site [chemical binding]; other site
400673004685	homohexameric interface [polypeptide binding]; other site
400673004686	elongation factor Ts; Provisional; Region: tsf; PRK09377
400673004687	UBA/TS-N domain; Region: UBA; pfam00627
400673004688	Elongation factor TS; Region: EF_TS; pfam00889
400673004689	Elongation factor TS; Region: EF_TS; pfam00889
400673004690	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
400673004691	rRNA interaction site [nucleotide binding]; other site
400673004692	S8 interaction site; other site
400673004693	putative laminin-1 binding site; other site
400673004694	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
400673004695	dimer interface [polypeptide binding]; other site
400673004696	Protein kinase domain; Region: Pkinase; pfam00069
400673004697	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673004698	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673004699	SET domain; Region: SET; pfam00856
400673004700	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673004701	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673004702	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
400673004703	active site
400673004704	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
400673004705	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
400673004706	metal binding triad; other site
400673004707	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
400673004708	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
400673004709	Zn2+ binding site [ion binding]; other site
400673004710	Mg2+ binding site [ion binding]; other site
400673004711	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
400673004712	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
400673004713	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
400673004714	nucleoside/Zn binding site; other site
400673004715	dimer interface [polypeptide binding]; other site
400673004716	catalytic motif [active]
400673004717	GMP synthase; Reviewed; Region: guaA; PRK00074
400673004718	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
400673004719	AMP/PPi binding site [chemical binding]; other site
400673004720	candidate oxyanion hole; other site
400673004721	catalytic triad [active]
400673004722	potential glutamine specificity residues [chemical binding]; other site
400673004723	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
400673004724	ATP Binding subdomain [chemical binding]; other site
400673004725	Ligand Binding sites [chemical binding]; other site
400673004726	Dimerization subdomain; other site
400673004727	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
400673004728	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
400673004729	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
400673004730	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
400673004731	active site
400673004732	four helix bundle protein; Region: TIGR02436
400673004733	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
400673004734	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
400673004735	active site
400673004736	catalytic residues [active]
400673004737	four helix bundle protein; Region: TIGR02436
400673004738	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
400673004739	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
400673004740	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
400673004741	Switch I; other site
400673004742	Switch II; other site
400673004743	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
400673004744	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
400673004745	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
400673004746	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
400673004747	active site
400673004748	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
400673004749	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673004750	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
400673004751	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
400673004752	Walker A/P-loop; other site
400673004753	ATP binding site [chemical binding]; other site
400673004754	Q-loop/lid; other site
400673004755	ABC transporter signature motif; other site
400673004756	Walker B; other site
400673004757	D-loop; other site
400673004758	H-loop/switch region; other site
400673004759	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
400673004760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673004761	dimer interface [polypeptide binding]; other site
400673004762	conserved gate region; other site
400673004763	putative PBP binding loops; other site
400673004764	ABC-ATPase subunit interface; other site
400673004765	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
400673004766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673004767	dimer interface [polypeptide binding]; other site
400673004768	conserved gate region; other site
400673004769	putative PBP binding loops; other site
400673004770	ABC-ATPase subunit interface; other site
400673004771	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
400673004772	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
400673004773	NAD(P) binding site [chemical binding]; other site
400673004774	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
400673004775	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
400673004776	Cl- selectivity filter; other site
400673004777	Cl- binding residues [ion binding]; other site
400673004778	pore gating glutamate residue; other site
400673004779	dimer interface [polypeptide binding]; other site
400673004780	H+/Cl- coupling transport residue; other site
400673004781	anthranilate synthase; Provisional; Region: PRK13566
400673004782	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
400673004783	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
400673004784	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
400673004785	glutamine binding [chemical binding]; other site
400673004786	catalytic triad [active]
400673004787	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
400673004788	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
400673004789	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
400673004790	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
400673004791	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
400673004792	GatB domain; Region: GatB_Yqey; smart00845
400673004793	Autotransporter beta-domain; Region: Autotransporter; smart00869
400673004794	CHASE2 domain; Region: CHASE2; pfam05226
400673004795	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
400673004796	cyclase homology domain; Region: CHD; cd07302
400673004797	nucleotidyl binding site; other site
400673004798	metal binding site [ion binding]; metal-binding site
400673004799	dimer interface [polypeptide binding]; other site
400673004800	FecR protein; Region: FecR; pfam04773
400673004801	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
400673004802	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
400673004803	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
400673004804	trimerization site [polypeptide binding]; other site
400673004805	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
400673004806	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
400673004807	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673004808	catalytic residue [active]
400673004809	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
400673004810	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
400673004811	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
400673004812	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
400673004813	active site
400673004814	dimerization interface [polypeptide binding]; other site
400673004815	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
400673004816	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
400673004817	tandem repeat interface [polypeptide binding]; other site
400673004818	oligomer interface [polypeptide binding]; other site
400673004819	active site residues [active]
400673004820	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
400673004821	Clp amino terminal domain; Region: Clp_N; pfam02861
400673004822	Clp amino terminal domain; Region: Clp_N; pfam02861
400673004823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673004824	Walker A motif; other site
400673004825	ATP binding site [chemical binding]; other site
400673004826	Walker B motif; other site
400673004827	arginine finger; other site
400673004828	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
400673004829	primary dimer interface [polypeptide binding]; other site
400673004830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673004831	Walker A motif; other site
400673004832	ATP binding site [chemical binding]; other site
400673004833	Walker B motif; other site
400673004834	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
400673004835	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
400673004836	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
400673004837	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
400673004838	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673004839	TIGR02099 family protein; Region: TIGR02099
400673004840	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
400673004841	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
400673004842	Flagellar FliJ protein; Region: FliJ; pfam02050
400673004843	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
400673004844	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
400673004845	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
400673004846	Walker A motif/ATP binding site; other site
400673004847	Walker B motif; other site
400673004848	Flagellar assembly protein FliH; Region: FliH; pfam02108
400673004849	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
400673004850	FliG C-terminal domain; Region: FliG_C; pfam01706
400673004851	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
400673004852	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
400673004853	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
400673004854	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
400673004855	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
400673004856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673004857	active site
400673004858	phosphorylation site [posttranslational modification]
400673004859	intermolecular recognition site; other site
400673004860	dimerization interface [polypeptide binding]; other site
400673004861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673004862	Walker A motif; other site
400673004863	ATP binding site [chemical binding]; other site
400673004864	Walker B motif; other site
400673004865	arginine finger; other site
400673004866	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
400673004867	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
400673004868	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673004869	putative active site [active]
400673004870	heme pocket [chemical binding]; other site
400673004871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673004872	dimer interface [polypeptide binding]; other site
400673004873	phosphorylation site [posttranslational modification]
400673004874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673004875	ATP binding site [chemical binding]; other site
400673004876	G-X-G motif; other site
400673004877	recombination factor protein RarA; Reviewed; Region: PRK13342
400673004878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673004879	Walker A motif; other site
400673004880	ATP binding site [chemical binding]; other site
400673004881	Walker B motif; other site
400673004882	arginine finger; other site
400673004883	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
400673004884	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
400673004885	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
400673004886	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
400673004887	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
400673004888	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
400673004889	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
400673004890	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
400673004891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
400673004892	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
400673004893	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
400673004894	active site residue [active]
400673004895	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
400673004896	rRNA binding site [nucleotide binding]; other site
400673004897	predicted 30S ribosome binding site; other site
400673004898	peptidase PmbA; Provisional; Region: PRK11040
400673004899	Predicted periplasmic protein [Function unknown]; Region: COG3698
400673004900	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
400673004901	Cupin-like domain; Region: Cupin_8; pfam13621
400673004902	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
400673004903	ATP cone domain; Region: ATP-cone; pfam03477
400673004904	ATP cone domain; Region: ATP-cone; pfam03477
400673004905	Class I ribonucleotide reductase; Region: RNR_I; cd01679
400673004906	active site
400673004907	dimer interface [polypeptide binding]; other site
400673004908	catalytic residues [active]
400673004909	effector binding site; other site
400673004910	R2 peptide binding site; other site
400673004911	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
400673004912	dimer interface [polypeptide binding]; other site
400673004913	putative radical transfer pathway; other site
400673004914	diiron center [ion binding]; other site
400673004915	tyrosyl radical; other site
400673004916	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
400673004917	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
400673004918	dimer interface [polypeptide binding]; other site
400673004919	putative anticodon binding site; other site
400673004920	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
400673004921	motif 1; other site
400673004922	active site
400673004923	motif 2; other site
400673004924	motif 3; other site
400673004925	peptide chain release factor 2; Validated; Region: prfB; PRK00578
400673004926	This domain is found in peptide chain release factors; Region: PCRF; smart00937
400673004927	RF-1 domain; Region: RF-1; pfam00472
400673004928	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
400673004929	flagellar motor protein MotD; Reviewed; Region: PRK09038
400673004930	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
400673004931	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673004932	ligand binding site [chemical binding]; other site
400673004933	flagellar motor protein; Reviewed; Region: motC; PRK09109
400673004934	flagellar motor protein MotA; Validated; Region: PRK08124
400673004935	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
400673004936	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
400673004937	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
400673004938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
400673004939	DNA binding residues [nucleotide binding]
400673004940	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
400673004941	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
400673004942	P-loop; other site
400673004943	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
400673004944	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
400673004945	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
400673004946	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
400673004947	FHIPEP family; Region: FHIPEP; pfam00771
400673004948	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
400673004949	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
400673004950	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
400673004951	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
400673004952	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
400673004953	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
400673004954	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
400673004955	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
400673004956	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
400673004957	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
400673004958	FAD binding domain; Region: FAD_binding_4; pfam01565
400673004959	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
400673004960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673004961	NAD(P) binding site [chemical binding]; other site
400673004962	active site
400673004963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673004964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673004965	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
400673004966	dimerization interface [polypeptide binding]; other site
400673004967	Transposase; Region: HTH_Tnp_IS630; pfam01710
400673004968	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
400673004969	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
400673004970	GTPase interaction site; other site
400673004971	catalytic residue [active]
400673004972	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
400673004973	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
400673004974	motif 1; other site
400673004975	active site
400673004976	motif 2; other site
400673004977	motif 3; other site
400673004978	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
400673004979	recombination regulator RecX; Reviewed; Region: recX; PRK00117
400673004980	recombinase A; Provisional; Region: recA; PRK09354
400673004981	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
400673004982	hexamer interface [polypeptide binding]; other site
400673004983	Walker A motif; other site
400673004984	ATP binding site [chemical binding]; other site
400673004985	Walker B motif; other site
400673004986	Competence-damaged protein; Region: CinA; pfam02464
400673004987	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
400673004988	MutS domain I; Region: MutS_I; pfam01624
400673004989	MutS domain II; Region: MutS_II; pfam05188
400673004990	MutS domain III; Region: MutS_III; pfam05192
400673004991	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
400673004992	Walker A/P-loop; other site
400673004993	ATP binding site [chemical binding]; other site
400673004994	Q-loop/lid; other site
400673004995	ABC transporter signature motif; other site
400673004996	Walker B; other site
400673004997	D-loop; other site
400673004998	H-loop/switch region; other site
400673004999	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
400673005000	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
400673005001	Surface antigen; Region: Bac_surface_Ag; pfam01103
400673005002	Family of unknown function (DUF490); Region: DUF490; pfam04357
400673005003	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
400673005004	dimer interface [polypeptide binding]; other site
400673005005	active site
400673005006	Schiff base residues; other site
400673005007	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
400673005008	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
400673005009	AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259
400673005010	putative catalytic residues [active]
400673005011	putative nucleotide binding site [chemical binding]; other site
400673005012	putative aspartate binding site [chemical binding]; other site
400673005013	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
400673005014	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920
400673005015	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840
400673005016	active site
400673005017	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
400673005018	substrate binding site [chemical binding]; other site
400673005019	catalytic residues [active]
400673005020	dimer interface [polypeptide binding]; other site
400673005021	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
400673005022	Part of AAA domain; Region: AAA_19; pfam13245
400673005023	Family description; Region: UvrD_C_2; pfam13538
400673005024	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
400673005025	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
400673005026	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
400673005027	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
400673005028	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673005029	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
400673005030	dimerization interface [polypeptide binding]; other site
400673005031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673005032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673005033	putative substrate translocation pore; other site
400673005034	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
400673005035	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
400673005036	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
400673005037	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673005038	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
400673005039	Walker A/P-loop; other site
400673005040	ATP binding site [chemical binding]; other site
400673005041	Q-loop/lid; other site
400673005042	ABC transporter signature motif; other site
400673005043	Walker B; other site
400673005044	D-loop; other site
400673005045	H-loop/switch region; other site
400673005046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673005047	Coenzyme A binding pocket [chemical binding]; other site
400673005048	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
400673005049	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
400673005050	quinone interaction residues [chemical binding]; other site
400673005051	active site
400673005052	catalytic residues [active]
400673005053	FMN binding site [chemical binding]; other site
400673005054	substrate binding site [chemical binding]; other site
400673005055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673005056	isovaleryl-CoA dehydrogenase; Region: PLN02519
400673005057	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
400673005058	substrate binding site [chemical binding]; other site
400673005059	FAD binding site [chemical binding]; other site
400673005060	catalytic base [active]
400673005061	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
400673005062	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
400673005063	dimer interface [polypeptide binding]; other site
400673005064	active site
400673005065	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
400673005066	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
400673005067	enoyl-CoA hydratase; Provisional; Region: PRK05995
400673005068	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
400673005069	substrate binding site [chemical binding]; other site
400673005070	oxyanion hole (OAH) forming residues; other site
400673005071	trimer interface [polypeptide binding]; other site
400673005072	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
400673005073	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
400673005074	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
400673005075	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
400673005076	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
400673005077	carboxyltransferase (CT) interaction site; other site
400673005078	biotinylation site [posttranslational modification]; other site
400673005079	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
400673005080	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
400673005081	active site
400673005082	catalytic residues [active]
400673005083	metal binding site [ion binding]; metal-binding site
400673005084	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
400673005085	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
400673005086	acyl-activating enzyme (AAE) consensus motif; other site
400673005087	putative AMP binding site [chemical binding]; other site
400673005088	putative active site [active]
400673005089	putative CoA binding site [chemical binding]; other site
400673005090	VirK protein; Region: VirK; pfam06903
400673005091	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
400673005092	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
400673005093	Walker A/P-loop; other site
400673005094	ATP binding site [chemical binding]; other site
400673005095	Q-loop/lid; other site
400673005096	ABC transporter signature motif; other site
400673005097	Walker B; other site
400673005098	D-loop; other site
400673005099	H-loop/switch region; other site
400673005100	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
400673005101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
400673005102	dimer interface [polypeptide binding]; other site
400673005103	conserved gate region; other site
400673005104	ABC-ATPase subunit interface; other site
400673005105	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
400673005106	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
400673005107	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
400673005108	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
400673005109	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673005110	active site
400673005111	motif I; other site
400673005112	motif II; other site
400673005113	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
400673005114	DALR anticodon binding domain; Region: DALR_1; pfam05746
400673005115	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
400673005116	dimer interface [polypeptide binding]; other site
400673005117	motif 1; other site
400673005118	active site
400673005119	motif 2; other site
400673005120	motif 3; other site
400673005121	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
400673005122	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
400673005123	catalytic residues [active]
400673005124	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
400673005125	Part of AAA domain; Region: AAA_19; pfam13245
400673005126	Family description; Region: UvrD_C_2; pfam13538
400673005127	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
400673005128	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
400673005129	putative active site [active]
400673005130	dimerization interface [polypeptide binding]; other site
400673005131	putative tRNAtyr binding site [nucleotide binding]; other site
400673005132	VacJ like lipoprotein; Region: VacJ; cl01073
400673005133	glutathione synthetase; Provisional; Region: PRK05246
400673005134	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
400673005135	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
400673005136	Glutamate-cysteine ligase; Region: GshA; pfam08886
400673005137	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
400673005138	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
400673005139	EamA-like transporter family; Region: EamA; pfam00892
400673005140	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
400673005141	active site residue [active]
400673005142	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
400673005143	PglZ domain; Region: PglZ; pfam08665
400673005144	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
400673005145	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
400673005146	Sugar specificity; other site
400673005147	Pyrimidine base specificity; other site
400673005148	ATP-binding site [chemical binding]; other site
400673005149	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
400673005150	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
400673005151	NAD binding site [chemical binding]; other site
400673005152	homotetramer interface [polypeptide binding]; other site
400673005153	homodimer interface [polypeptide binding]; other site
400673005154	substrate binding site [chemical binding]; other site
400673005155	active site
400673005156	periplasmic folding chaperone; Provisional; Region: PRK10788
400673005157	SurA N-terminal domain; Region: SurA_N_3; cl07813
400673005158	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
400673005159	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
400673005160	IHF dimer interface [polypeptide binding]; other site
400673005161	IHF - DNA interface [nucleotide binding]; other site
400673005162	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
400673005163	Found in ATP-dependent protease La (LON); Region: LON; smart00464
400673005164	Found in ATP-dependent protease La (LON); Region: LON; smart00464
400673005165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673005166	Walker A motif; other site
400673005167	ATP binding site [chemical binding]; other site
400673005168	Walker B motif; other site
400673005169	arginine finger; other site
400673005170	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
400673005171	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
400673005172	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
400673005173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673005174	Walker A motif; other site
400673005175	ATP binding site [chemical binding]; other site
400673005176	Walker B motif; other site
400673005177	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
400673005178	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
400673005179	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
400673005180	oligomer interface [polypeptide binding]; other site
400673005181	active site residues [active]
400673005182	trigger factor; Provisional; Region: tig; PRK01490
400673005183	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
400673005184	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
400673005185	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
400673005186	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
400673005187	Int/Topo IB signature motif; other site
400673005188	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
400673005189	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005190	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005191	ABC transporter; Region: ABC_tran_2; pfam12848
400673005192	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005193	ribonuclease III; Reviewed; Region: rnc; PRK00102
400673005194	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
400673005195	dimerization interface [polypeptide binding]; other site
400673005196	active site
400673005197	metal binding site [ion binding]; metal-binding site
400673005198	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
400673005199	dsRNA binding site [nucleotide binding]; other site
400673005200	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
400673005201	signal peptidase I; Provisional; Region: PRK10861
400673005202	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
400673005203	Catalytic site [active]
400673005204	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
400673005205	GTP-binding protein LepA; Provisional; Region: PRK05433
400673005206	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
400673005207	G1 box; other site
400673005208	putative GEF interaction site [polypeptide binding]; other site
400673005209	GTP/Mg2+ binding site [chemical binding]; other site
400673005210	Switch I region; other site
400673005211	G2 box; other site
400673005212	G3 box; other site
400673005213	Switch II region; other site
400673005214	G4 box; other site
400673005215	G5 box; other site
400673005216	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
400673005217	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
400673005218	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
400673005219	Transglycosylase SLT domain; Region: SLT_2; pfam13406
400673005220	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673005221	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673005222	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
400673005223	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
400673005224	GspL periplasmic domain; Region: GspL_C; cl14909
400673005225	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
400673005226	Sporulation related domain; Region: SPOR; cl10051
400673005227	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
400673005228	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
400673005229	Zn2+ binding site [ion binding]; other site
400673005230	Mg2+ binding site [ion binding]; other site
400673005231	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
400673005232	DNA repair protein RecN; Region: recN; TIGR00634
400673005233	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
400673005234	Trehalase; Region: Trehalase; cl17346
400673005235	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
400673005236	dimer interface [polypeptide binding]; other site
400673005237	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
400673005238	active site
400673005239	metal binding site [ion binding]; metal-binding site
400673005240	glutathione binding site [chemical binding]; other site
400673005241	hypothetical protein; Provisional; Region: PRK05208
400673005242	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
400673005243	acylphosphatase; Provisional; Region: PRK14451
400673005244	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
400673005245	putative active site [active]
400673005246	catalytic site [active]
400673005247	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
400673005248	PLD-like domain; Region: PLDc_2; pfam13091
400673005249	putative active site [active]
400673005250	catalytic site [active]
400673005251	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
400673005252	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
400673005253	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
400673005254	Leucine-rich repeats; other site
400673005255	Substrate binding site [chemical binding]; other site
400673005256	Leucine rich repeat; Region: LRR_8; pfam13855
400673005257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673005258	D-galactonate transporter; Region: 2A0114; TIGR00893
400673005259	putative substrate translocation pore; other site
400673005260	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
400673005261	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
400673005262	putative ion selectivity filter; other site
400673005263	putative pore gating glutamate residue; other site
400673005264	Transposase domain (DUF772); Region: DUF772; pfam05598
400673005265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
400673005266	SEC-C motif; Region: SEC-C; pfam02810
400673005267	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
400673005268	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
400673005269	TrkA-N domain; Region: TrkA_N; pfam02254
400673005270	MoxR-like ATPases [General function prediction only]; Region: COG0714
400673005271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673005272	Walker A motif; other site
400673005273	ATP binding site [chemical binding]; other site
400673005274	Walker B motif; other site
400673005275	arginine finger; other site
400673005276	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
400673005277	Protein of unknown function DUF58; Region: DUF58; pfam01882
400673005278	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
400673005279	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
400673005280	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
400673005281	Uncharacterized conserved protein [Function unknown]; Region: COG2850
400673005282	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
400673005283	GIY-YIG motif/motif A; other site
400673005284	putative active site [active]
400673005285	putative metal binding site [ion binding]; other site
400673005286	NlpC/P60 family; Region: NLPC_P60; cl17555
400673005287	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673005288	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
400673005289	EamA-like transporter family; Region: EamA; pfam00892
400673005290	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
400673005291	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
400673005292	nucleotide binding site [chemical binding]; other site
400673005293	Protein of unknown function, DUF462; Region: DUF462; pfam04315
400673005294	glutathionine S-transferase; Provisional; Region: PRK10542
400673005295	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
400673005296	C-terminal domain interface [polypeptide binding]; other site
400673005297	GSH binding site (G-site) [chemical binding]; other site
400673005298	dimer interface [polypeptide binding]; other site
400673005299	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
400673005300	N-terminal domain interface [polypeptide binding]; other site
400673005301	dimer interface [polypeptide binding]; other site
400673005302	substrate binding pocket (H-site) [chemical binding]; other site
400673005303	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
400673005304	Beta-lactamase; Region: Beta-lactamase; pfam00144
400673005305	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
400673005306	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
400673005307	HIGH motif; other site
400673005308	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
400673005309	active site
400673005310	KMSKS motif; other site
400673005311	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
400673005312	HAMP domain; Region: HAMP; pfam00672
400673005313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673005314	dimer interface [polypeptide binding]; other site
400673005315	phosphorylation site [posttranslational modification]
400673005316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673005317	ATP binding site [chemical binding]; other site
400673005318	Mg2+ binding site [ion binding]; other site
400673005319	G-X-G motif; other site
400673005320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673005321	active site
400673005322	phosphorylation site [posttranslational modification]
400673005323	intermolecular recognition site; other site
400673005324	dimerization interface [polypeptide binding]; other site
400673005325	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
400673005326	putative binding surface; other site
400673005327	active site
400673005328	6-phosphofructokinase; Provisional; Region: PRK14072
400673005329	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
400673005330	active site
400673005331	ADP/pyrophosphate binding site [chemical binding]; other site
400673005332	dimerization interface [polypeptide binding]; other site
400673005333	allosteric effector site; other site
400673005334	fructose-1,6-bisphosphate binding site; other site
400673005335	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
400673005336	Pilin (bacterial filament); Region: Pilin; pfam00114
400673005337	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
400673005338	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
400673005339	Pilin (bacterial filament); Region: Pilin; pfam00114
400673005340	BolA-like protein; Region: BolA; cl00386
400673005341	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
400673005342	Calcium-activated chloride channel; Region: Anoctamin; pfam04547
400673005343	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
400673005344	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
400673005345	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
400673005346	Ligand binding site; other site
400673005347	oligomer interface; other site
400673005348	Uncharacterized conserved protein [Function unknown]; Region: COG2835
400673005349	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
400673005350	Glycoprotease family; Region: Peptidase_M22; pfam00814
400673005351	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
400673005352	DEAD/DEAH box helicase; Region: DEAD; pfam00270
400673005353	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
400673005354	Ferredoxin [Energy production and conversion]; Region: COG1146
400673005355	4Fe-4S binding domain; Region: Fer4; pfam00037
400673005356	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
400673005357	PilZ domain; Region: PilZ; pfam07238
400673005358	oxidative damage protection protein; Provisional; Region: PRK05408
400673005359	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
400673005360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
400673005361	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673005362	transposase/IS protein; Provisional; Region: PRK09183
400673005363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673005364	Walker A motif; other site
400673005365	ATP binding site [chemical binding]; other site
400673005366	Walker B motif; other site
400673005367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
400673005368	Helix-turn-helix domain; Region: HTH_38; pfam13936
400673005369	Integrase core domain; Region: rve; pfam00665
400673005370	Integrase; Region: Integrase_1; pfam12835
400673005371	Domain of unknown function (DUF927); Region: DUF927; pfam06048
400673005372	Helix-turn-helix domain; Region: HTH_17; pfam12728
400673005373	LabA_like proteins; Region: LabA_like; cd06167
400673005374	putative metal binding site [ion binding]; other site
400673005375	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
400673005376	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
400673005377	active site
400673005378	DNA binding site [nucleotide binding]
400673005379	Int/Topo IB signature motif; other site
400673005380	Transposase; Region: HTH_Tnp_1; cl17663
400673005381	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
400673005382	active site clefts [active]
400673005383	zinc binding site [ion binding]; other site
400673005384	dimer interface [polypeptide binding]; other site
400673005385	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
400673005386	HipA N-terminal domain; Region: Couple_hipA; pfam13657
400673005387	HipA-like N-terminal domain; Region: HipA_N; pfam07805
400673005388	HipA-like C-terminal domain; Region: HipA_C; pfam07804
400673005389	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
400673005390	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673005391	non-specific DNA binding site [nucleotide binding]; other site
400673005392	salt bridge; other site
400673005393	sequence-specific DNA binding site [nucleotide binding]; other site
400673005394	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
400673005395	Methyltransferase domain; Region: Methyltransf_31; pfam13847
400673005396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673005397	S-adenosylmethionine binding site [chemical binding]; other site
400673005398	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
400673005399	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
400673005400	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
400673005401	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
400673005402	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
400673005403	active site
400673005404	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
400673005405	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
400673005406	acyl-activating enzyme (AAE) consensus motif; other site
400673005407	AMP binding site [chemical binding]; other site
400673005408	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
400673005409	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
400673005410	active site
400673005411	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
400673005412	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
400673005413	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
400673005414	Phosphopantetheine attachment site; Region: PP-binding; cl09936
400673005415	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
400673005416	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
400673005417	active site
400673005418	nucleophile elbow; other site
400673005419	Patatin phospholipase; Region: DUF3734; pfam12536
400673005420	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
400673005421	PAS fold; Region: PAS_4; pfam08448
400673005422	Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171
400673005423	active site/putative ARF binding site [active]
400673005424	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
400673005425	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
400673005426	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
400673005427	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
400673005428	active site
400673005429	metal binding site [ion binding]; metal-binding site
400673005430	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
400673005431	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
400673005432	active site
400673005433	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
400673005434	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
400673005435	DNA binding residues [nucleotide binding]
400673005436	Fic/DOC family; Region: Fic; cl00960
400673005437	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673005438	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
400673005439	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
400673005440	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
400673005441	active site
400673005442	potential frameshift: common BLAST hit: gi|289165842|ref|YP_003455980.1| Hypothetical protein, weakly similar to eukaryotic proteins
400673005443	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
400673005444	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
400673005445	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
400673005446	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673005447	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
400673005448	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
400673005449	active site
400673005450	AMP binding site [chemical binding]; other site
400673005451	acyl-activating enzyme (AAE) consensus motif; other site
400673005452	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
400673005453	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
400673005454	C-terminal domain interface [polypeptide binding]; other site
400673005455	GSH binding site (G-site) [chemical binding]; other site
400673005456	dimer interface [polypeptide binding]; other site
400673005457	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
400673005458	N-terminal domain interface [polypeptide binding]; other site
400673005459	dimer interface [polypeptide binding]; other site
400673005460	substrate binding pocket (H-site) [chemical binding]; other site
400673005461	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
400673005462	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673005463	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
400673005464	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
400673005465	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
400673005466	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
400673005467	intracellular protease, PfpI family; Region: PfpI; TIGR01382
400673005468	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
400673005469	conserved cys residue [active]
400673005470	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
400673005471	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
400673005472	guanine deaminase; Provisional; Region: PRK09228
400673005473	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
400673005474	active site
400673005475	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
400673005476	Toprim domain; Region: Toprim_3; pfam13362
400673005477	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
400673005478	catalytic core [active]
400673005479	RibD C-terminal domain; Region: RibD_C; cl17279
400673005480	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
400673005481	MAPEG family; Region: MAPEG; cl09190
400673005482	YhhN-like protein; Region: YhhN; pfam07947
400673005483	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
400673005484	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
400673005485	NodB motif; other site
400673005486	putative active site [active]
400673005487	putative catalytic site [active]
400673005488	putative Zn binding site [ion binding]; other site
400673005489	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
400673005490	MltA specific insert domain; Region: MltA; pfam03562
400673005491	3D domain; Region: 3D; pfam06725
400673005492	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
400673005493	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
400673005494	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
400673005495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
400673005496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673005497	homodimer interface [polypeptide binding]; other site
400673005498	catalytic residue [active]
400673005499	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
400673005500	aromatic arch; other site
400673005501	DCoH dimer interaction site [polypeptide binding]; other site
400673005502	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
400673005503	DCoH tetramer interaction site [polypeptide binding]; other site
400673005504	substrate binding site [chemical binding]; other site
400673005505	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
400673005506	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
400673005507	Protein export membrane protein; Region: SecD_SecF; pfam02355
400673005508	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
400673005509	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
400673005510	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
400673005511	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
400673005512	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
400673005513	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
400673005514	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
400673005515	ABC transporter ATPase component; Reviewed; Region: PRK11147
400673005516	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005517	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005518	ABC transporter; Region: ABC_tran_2; pfam12848
400673005519	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
400673005520	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
400673005521	catalytic motif [active]
400673005522	Catalytic residue [active]
400673005523	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
400673005524	homotrimer interaction site [polypeptide binding]; other site
400673005525	putative active site [active]
400673005526	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
400673005527	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
400673005528	Zn2+ binding site [ion binding]; other site
400673005529	Mg2+ binding site [ion binding]; other site
400673005530	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
400673005531	synthetase active site [active]
400673005532	NTP binding site [chemical binding]; other site
400673005533	metal binding site [ion binding]; metal-binding site
400673005534	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
400673005535	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
400673005536	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
400673005537	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
400673005538	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
400673005539	catalytic site [active]
400673005540	G-X2-G-X-G-K; other site
400673005541	hypothetical protein; Provisional; Region: PRK11820
400673005542	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
400673005543	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
400673005544	ribonuclease PH; Reviewed; Region: rph; PRK00173
400673005545	Ribonuclease PH; Region: RNase_PH_bact; cd11362
400673005546	hexamer interface [polypeptide binding]; other site
400673005547	active site
400673005548	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
400673005549	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
400673005550	Walker A motif; other site
400673005551	ATP binding site [chemical binding]; other site
400673005552	Walker B motif; other site
400673005553	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
400673005554	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
400673005555	catalytic residue [active]
400673005556	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
400673005557	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
400673005558	YGGT family; Region: YGGT; pfam02325
400673005559	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
400673005560	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
400673005561	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
400673005562	active site
400673005563	catalytic residues [active]
400673005564	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
400673005565	Helix-turn-helix domain; Region: HTH_18; pfam12833
400673005566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
400673005567	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
400673005568	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
400673005569	homotetramer interface [polypeptide binding]; other site
400673005570	ligand binding site [chemical binding]; other site
400673005571	catalytic site [active]
400673005572	NAD binding site [chemical binding]; other site
400673005573	S-adenosylmethionine synthetase; Validated; Region: PRK05250
400673005574	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
400673005575	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
400673005576	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
400673005577	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
400673005578	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
400673005579	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
400673005580	catalytic site [active]
400673005581	subunit interface [polypeptide binding]; other site
400673005582	chaperone protein DnaJ; Provisional; Region: PRK10767
400673005583	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
400673005584	HSP70 interaction site [polypeptide binding]; other site
400673005585	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
400673005586	substrate binding site [polypeptide binding]; other site
400673005587	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
400673005588	Zn binding sites [ion binding]; other site
400673005589	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
400673005590	dimer interface [polypeptide binding]; other site
400673005591	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
400673005592	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
400673005593	nucleotide binding site [chemical binding]; other site
400673005594	GrpE; Region: GrpE; pfam01025
400673005595	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
400673005596	dimer interface [polypeptide binding]; other site
400673005597	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
400673005598	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
400673005599	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
400673005600	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
400673005601	substrate binding site [chemical binding]; other site
400673005602	active site
400673005603	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
400673005604	homooctamer interface [polypeptide binding]; other site
400673005605	active site
400673005606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
400673005607	Sporulation related domain; Region: SPOR; pfam05036
400673005608	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
400673005609	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
400673005610	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673005611	active site
400673005612	HIGH motif; other site
400673005613	nucleotide binding site [chemical binding]; other site
400673005614	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
400673005615	KMSK motif region; other site
400673005616	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
400673005617	tRNA binding surface [nucleotide binding]; other site
400673005618	anticodon binding site; other site
400673005619	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
400673005620	Domain of unknown function DUF20; Region: UPF0118; pfam01594
400673005621	ATP-dependent DNA helicase RecG; Region: recG; TIGR00643
400673005622	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
400673005623	ssDNA binding site; other site
400673005624	generic binding surface II; other site
400673005625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673005626	ATP binding site [chemical binding]; other site
400673005627	putative Mg++ binding site [ion binding]; other site
400673005628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673005629	nucleotide binding region [chemical binding]; other site
400673005630	ATP-binding site [chemical binding]; other site
400673005631	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
400673005632	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
400673005633	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
400673005634	ZIP Zinc transporter; Region: Zip; pfam02535
400673005635	Maf-like protein; Region: Maf; pfam02545
400673005636	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
400673005637	active site
400673005638	dimer interface [polypeptide binding]; other site
400673005639	enolase; Provisional; Region: eno; PRK00077
400673005640	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
400673005641	dimer interface [polypeptide binding]; other site
400673005642	metal binding site [ion binding]; metal-binding site
400673005643	substrate binding pocket [chemical binding]; other site
400673005644	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
400673005645	Septum formation initiator; Region: DivIC; cl17659
400673005646	mevalonate kinase; Region: mevalon_kin; TIGR00549
400673005647	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
400673005648	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
400673005649	diphosphomevalonate decarboxylase; Region: PLN02407
400673005650	diphosphomevalonate decarboxylase; Region: PLN02407
400673005651	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
400673005652	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673005653	FeS/SAM binding site; other site
400673005654	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673005655	binding surface
400673005656	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
400673005657	TPR motif; other site
400673005658	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
400673005659	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673005660	ligand binding site [chemical binding]; other site
400673005661	Protein of unknown function (DUF330); Region: DUF330; cl01135
400673005662	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
400673005663	mce related protein; Region: MCE; pfam02470
400673005664	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
400673005665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673005666	Walker A/P-loop; other site
400673005667	ATP binding site [chemical binding]; other site
400673005668	Q-loop/lid; other site
400673005669	ABC transporter signature motif; other site
400673005670	Walker B; other site
400673005671	D-loop; other site
400673005672	H-loop/switch region; other site
400673005673	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
400673005674	Permease; Region: Permease; pfam02405
400673005675	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
400673005676	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
400673005677	active site
400673005678	ATP binding site [chemical binding]; other site
400673005679	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
400673005680	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
400673005681	homotetramer interface [polypeptide binding]; other site
400673005682	FMN binding site [chemical binding]; other site
400673005683	homodimer contacts [polypeptide binding]; other site
400673005684	putative active site [active]
400673005685	putative substrate binding site [chemical binding]; other site
400673005686	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
400673005687	homodimer interface [polypeptide binding]; other site
400673005688	catalytic residues [active]
400673005689	NAD binding site [chemical binding]; other site
400673005690	substrate binding pocket [chemical binding]; other site
400673005691	flexible flap; other site
400673005692	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
400673005693	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
400673005694	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
400673005695	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
400673005696	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673005697	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
400673005698	DNA-binding site [nucleotide binding]; DNA binding site
400673005699	RNA-binding motif; other site
400673005700	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
400673005701	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
400673005702	ATP binding site [chemical binding]; other site
400673005703	Mg++ binding site [ion binding]; other site
400673005704	motif III; other site
400673005705	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673005706	nucleotide binding region [chemical binding]; other site
400673005707	ATP-binding site [chemical binding]; other site
400673005708	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
400673005709	putative RNA binding site [nucleotide binding]; other site
400673005710	Cation efflux family; Region: Cation_efflux; cl00316
400673005711	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
400673005712	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
400673005713	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
400673005714	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
400673005715	GIY-YIG motif/motif A; other site
400673005716	putative active site [active]
400673005717	putative metal binding site [ion binding]; other site
400673005718	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
400673005719	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
400673005720	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
400673005721	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005722	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005723	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005724	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005725	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005726	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005727	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673005729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673005730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
400673005731	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005732	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005733	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005734	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005735	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005736	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005737	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005738	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005739	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005740	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673005741	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673005742	ligand binding site [chemical binding]; other site
400673005743	K+ potassium transporter; Region: K_trans; pfam02705
400673005744	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005745	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005746	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
400673005747	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673005748	PAS domain S-box; Region: sensory_box; TIGR00229
400673005749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673005750	putative active site [active]
400673005751	heme pocket [chemical binding]; other site
400673005752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673005753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673005754	metal binding site [ion binding]; metal-binding site
400673005755	active site
400673005756	I-site; other site
400673005757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673005758	putative substrate translocation pore; other site
400673005759	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673005760	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
400673005761	Protein export membrane protein; Region: SecD_SecF; cl14618
400673005762	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
400673005763	carboxyltransferase (CT) interaction site; other site
400673005764	biotinylation site [posttranslational modification]; other site
400673005765	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673005766	Outer membrane efflux protein; Region: OEP; pfam02321
400673005767	Outer membrane efflux protein; Region: OEP; pfam02321
400673005768	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
400673005769	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
400673005770	active site
400673005771	ATP binding site [chemical binding]; other site
400673005772	substrate binding site [chemical binding]; other site
400673005773	activation loop (A-loop); other site
400673005774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673005775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673005776	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
400673005777	putative substrate binding pocket [chemical binding]; other site
400673005778	putative dimerization interface [polypeptide binding]; other site
400673005779	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
400673005780	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
400673005781	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
400673005782	Predicted transcriptional regulators [Transcription]; Region: COG1733
400673005783	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
400673005784	classical (c) SDRs; Region: SDR_c; cd05233
400673005785	NAD(P) binding site [chemical binding]; other site
400673005786	active site
400673005787	F-box-like; Region: F-box-like; cl02535
400673005788	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
400673005789	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005790	Response regulator receiver domain; Region: Response_reg; pfam00072
400673005791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673005792	active site
400673005793	phosphorylation site [posttranslational modification]
400673005794	intermolecular recognition site; other site
400673005795	dimerization interface [polypeptide binding]; other site
400673005796	PAS domain; Region: PAS; smart00091
400673005797	PAS fold; Region: PAS_4; pfam08448
400673005798	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
400673005799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673005800	dimer interface [polypeptide binding]; other site
400673005801	phosphorylation site [posttranslational modification]
400673005802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673005803	ATP binding site [chemical binding]; other site
400673005804	Mg2+ binding site [ion binding]; other site
400673005805	G-X-G motif; other site
400673005806	Response regulator receiver domain; Region: Response_reg; pfam00072
400673005807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673005808	active site
400673005809	phosphorylation site [posttranslational modification]
400673005810	intermolecular recognition site; other site
400673005811	dimerization interface [polypeptide binding]; other site
400673005812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673005813	dimer interface [polypeptide binding]; other site
400673005814	phosphorylation site [posttranslational modification]
400673005815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673005816	ATP binding site [chemical binding]; other site
400673005817	Mg2+ binding site [ion binding]; other site
400673005818	G-X-G motif; other site
400673005819	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
400673005820	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673005821	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
400673005822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673005823	Walker A/P-loop; other site
400673005824	ATP binding site [chemical binding]; other site
400673005825	Q-loop/lid; other site
400673005826	ABC transporter signature motif; other site
400673005827	Walker B; other site
400673005828	D-loop; other site
400673005829	H-loop/switch region; other site
400673005830	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005831	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005832	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005833	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673005834	Protein of unknown function (DUF3638); Region: DUF3638; pfam12340
400673005835	Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951
400673005836	Helix-turn-helix domain; Region: HTH_28; pfam13518
400673005837	Winged helix-turn helix; Region: HTH_29; pfam13551
400673005838	Homeodomain-like domain; Region: HTH_32; pfam13565
400673005839	Integrase core domain; Region: rve; pfam00665
400673005840	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
400673005841	Integrase core domain; Region: rve_3; pfam13683
400673005842	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005843	Dot/Icm substrate protein; Region: SidE; pfam12252
400673005844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673005845	S-adenosylmethionine binding site [chemical binding]; other site
400673005846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673005847	S-adenosylmethionine binding site [chemical binding]; other site
400673005848	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
400673005849	Predicted transcriptional regulator [Transcription]; Region: COG2378
400673005850	HTH domain; Region: HTH_11; pfam08279
400673005851	WYL domain; Region: WYL; pfam13280
400673005852	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
400673005853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673005854	Coenzyme A binding pocket [chemical binding]; other site
400673005855	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
400673005856	putative dimer interface [polypeptide binding]; other site
400673005857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
400673005858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673005859	Coenzyme A binding pocket [chemical binding]; other site
400673005860	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673005861	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
400673005862	Coenzyme A binding pocket [chemical binding]; other site
400673005863	S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499
400673005864	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
400673005865	NAD binding site [chemical binding]; other site
400673005866	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
400673005867	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
400673005868	active site
400673005869	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
400673005870	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673005871	catalytic residue [active]
400673005872	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673005873	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673005874	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673005875	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
400673005876	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
400673005877	putative binding surface; other site
400673005878	active site
400673005879	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
400673005880	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
400673005881	acyl-activating enzyme (AAE) consensus motif; other site
400673005882	AMP binding site [chemical binding]; other site
400673005883	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
400673005884	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
400673005885	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
400673005886	active site
400673005887	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
400673005888	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
400673005889	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
400673005890	putative NADP binding site [chemical binding]; other site
400673005891	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
400673005892	active site
400673005893	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
400673005894	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
400673005895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673005896	dimer interface [polypeptide binding]; other site
400673005897	phosphorylation site [posttranslational modification]
400673005898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673005899	ATP binding site [chemical binding]; other site
400673005900	Mg2+ binding site [ion binding]; other site
400673005901	G-X-G motif; other site
400673005902	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
400673005903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673005904	active site
400673005905	phosphorylation site [posttranslational modification]
400673005906	intermolecular recognition site; other site
400673005907	dimerization interface [polypeptide binding]; other site
400673005908	Response regulator receiver domain; Region: Response_reg; pfam00072
400673005909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673005910	active site
400673005911	phosphorylation site [posttranslational modification]
400673005912	intermolecular recognition site; other site
400673005913	dimerization interface [polypeptide binding]; other site
400673005914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673005915	Methyltransferase domain; Region: Methyltransf_31; pfam13847
400673005916	S-adenosylmethionine binding site [chemical binding]; other site
400673005917	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
400673005918	tuzin; Provisional; Region: PTZ00202
400673005919	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
400673005920	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
400673005921	active site
400673005922	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
400673005923	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
400673005924	active site
400673005925	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
400673005926	KR domain; Region: KR; pfam08659
400673005927	NADP binding site [chemical binding]; other site
400673005928	active site
400673005929	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
400673005930	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
400673005931	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
400673005932	active site
400673005933	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
400673005934	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
400673005935	KR domain; Region: KR; pfam08659
400673005936	putative NADP binding site [chemical binding]; other site
400673005937	active site
400673005938	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
400673005939	Condensation domain; Region: Condensation; pfam00668
400673005940	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
400673005941	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673005942	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673005943	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
400673005944	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
400673005945	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
400673005946	putative dimer interface [polypeptide binding]; other site
400673005947	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
400673005948	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
400673005949	putative dimer interface [polypeptide binding]; other site
400673005950	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
400673005951	Sulfate transporter family; Region: Sulfate_transp; pfam00916
400673005952	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
400673005953	active site clefts [active]
400673005954	zinc binding site [ion binding]; other site
400673005955	dimer interface [polypeptide binding]; other site
400673005956	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
400673005957	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
400673005958	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
400673005959	SnoaL-like domain; Region: SnoaL_3; pfam13474
400673005960	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673005961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673005962	S-adenosylmethionine binding site [chemical binding]; other site
400673005963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673005964	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
400673005965	putative substrate translocation pore; other site
400673005966	POT family; Region: PTR2; cl17359
400673005967	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
400673005968	hypothetical protein; Reviewed; Region: PRK09588
400673005969	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
400673005970	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
400673005971	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
400673005972	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
400673005973	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
400673005974	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
400673005975	putative NAD(P) binding site [chemical binding]; other site
400673005976	dimer interface [polypeptide binding]; other site
400673005977	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
400673005978	substrate binding site [chemical binding]; other site
400673005979	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
400673005980	YARHG domain; Region: YARHG; pfam13308
400673005981	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
400673005982	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
400673005983	active site
400673005984	metal binding site [ion binding]; metal-binding site
400673005985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673005986	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
400673005987	NAD(P) binding site [chemical binding]; other site
400673005988	active site
400673005989	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
400673005990	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673005991	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
400673005992	active site
400673005993	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
400673005994	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
400673005995	iron-sulfur cluster [ion binding]; other site
400673005996	[2Fe-2S] cluster binding site [ion binding]; other site
400673005997	C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883
400673005998	putative alpha subunit interface [polypeptide binding]; other site
400673005999	putative active site [active]
400673006000	putative substrate binding site [chemical binding]; other site
400673006001	Fe binding site [ion binding]; other site
400673006002	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
400673006003	putative trimer interface [polypeptide binding]; other site
400673006004	putative CoA binding site [chemical binding]; other site
400673006005	Sel1 repeat; Region: Sel1; cl02723
400673006006	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673006007	Sel1-like repeats; Region: SEL1; smart00671
400673006008	Sel1 repeat; Region: Sel1; pfam08238
400673006009	Sel1-like repeats; Region: SEL1; smart00671
400673006010	Sel1-like repeats; Region: SEL1; smart00671
400673006011	Sel1-like repeats; Region: SEL1; smart00671
400673006012	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673006013	GH3 auxin-responsive promoter; Region: GH3; pfam03321
400673006014	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
400673006015	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
400673006016	active site
400673006017	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
400673006018	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
400673006019	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
400673006020	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
400673006021	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
400673006022	active site
400673006023	acyl-CoA synthetase; Validated; Region: PRK05850
400673006024	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
400673006025	acyl-activating enzyme (AAE) consensus motif; other site
400673006026	active site
400673006027	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
400673006028	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
400673006029	acyl-activating enzyme (AAE) consensus motif; other site
400673006030	AMP binding site [chemical binding]; other site
400673006031	active site
400673006032	CoA binding site [chemical binding]; other site
400673006033	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
400673006034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673006035	NAD(P) binding site [chemical binding]; other site
400673006036	active site
400673006037	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
400673006038	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
400673006039	dimer interface [polypeptide binding]; other site
400673006040	active site
400673006041	CoA binding pocket [chemical binding]; other site
400673006042	Phosphopantetheine attachment site; Region: PP-binding; cl09936
400673006043	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
400673006044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006045	putative substrate translocation pore; other site
400673006046	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
400673006047	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
400673006048	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
400673006049	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
400673006050	Binuclear center (active site) [active]
400673006051	K-pathway; other site
400673006052	Putative proton exit pathway; other site
400673006053	Putative water exit pathway; other site
400673006054	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
400673006055	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
400673006056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673006057	Walker A/P-loop; other site
400673006058	ATP binding site [chemical binding]; other site
400673006059	Q-loop/lid; other site
400673006060	ABC transporter signature motif; other site
400673006061	Walker B; other site
400673006062	D-loop; other site
400673006063	H-loop/switch region; other site
400673006064	MAPEG family; Region: MAPEG; cl09190
400673006065	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
400673006066	active site
400673006067	nucleophile elbow; other site
400673006068	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
400673006069	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673006070	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
400673006071	hypothetical protein; Validated; Region: PRK07198
400673006072	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
400673006073	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
400673006074	dimerization interface [polypeptide binding]; other site
400673006075	active site
400673006076	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
400673006077	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673006078	active site
400673006079	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
400673006080	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
400673006081	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
400673006082	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
400673006083	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
400673006084	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
400673006085	catalytic triad [active]
400673006086	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
400673006087	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
400673006088	putative active site [active]
400673006089	metal binding site [ion binding]; metal-binding site
400673006090	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
400673006091	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
400673006092	NAD(P) binding site [chemical binding]; other site
400673006093	catalytic residues [active]
400673006094	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
400673006095	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
400673006096	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
400673006097	hypothetical protein; Provisional; Region: PRK05409
400673006098	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
400673006099	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
400673006100	Beta-Casp domain; Region: Beta-Casp; pfam10996
400673006101	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
400673006102	BON domain; Region: BON; pfam04972
400673006103	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
400673006104	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
400673006105	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
400673006106	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
400673006107	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
400673006108	dimer interaction site [polypeptide binding]; other site
400673006109	substrate-binding tunnel; other site
400673006110	active site
400673006111	catalytic site [active]
400673006112	substrate binding site [chemical binding]; other site
400673006113	phosphate acetyltransferase; Provisional; Region: PRK11890
400673006114	Acetokinase family; Region: Acetate_kinase; cl17229
400673006115	propionate/acetate kinase; Provisional; Region: PRK12379
400673006116	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
400673006117	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
400673006118	HSP70 interaction site [polypeptide binding]; other site
400673006119	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
400673006120	substrate binding site [polypeptide binding]; other site
400673006121	dimer interface [polypeptide binding]; other site
400673006122	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
400673006123	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
400673006124	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
400673006125	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
400673006126	putative acyl-acceptor binding pocket; other site
400673006127	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
400673006128	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
400673006129	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
400673006130	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
400673006131	active site
400673006132	probable DNA repair protein; Region: TIGR03623
400673006133	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
400673006134	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
400673006135	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
400673006136	putative NAD(P) binding site [chemical binding]; other site
400673006137	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
400673006138	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
400673006139	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
400673006140	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
400673006141	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
400673006142	putative active site [active]
400673006143	catalytic site [active]
400673006144	putative metal binding site [ion binding]; other site
400673006145	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
400673006146	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
400673006147	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
400673006148	NAD binding site [chemical binding]; other site
400673006149	Phe binding site; other site
400673006150	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
400673006151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006152	S-adenosylmethionine binding site [chemical binding]; other site
400673006153	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
400673006154	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
400673006155	dimer interface [polypeptide binding]; other site
400673006156	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
400673006157	active site
400673006158	Fe binding site [ion binding]; other site
400673006159	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
400673006160	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
400673006161	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
400673006162	maleylacetoacetate isomerase; Region: maiA; TIGR01262
400673006163	C-terminal domain interface [polypeptide binding]; other site
400673006164	GSH binding site (G-site) [chemical binding]; other site
400673006165	putative dimer interface [polypeptide binding]; other site
400673006166	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
400673006167	dimer interface [polypeptide binding]; other site
400673006168	N-terminal domain interface [polypeptide binding]; other site
400673006169	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
400673006170	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
400673006171	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
400673006172	putative dimer interface [polypeptide binding]; other site
400673006173	putative anticodon binding site; other site
400673006174	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
400673006175	homodimer interface [polypeptide binding]; other site
400673006176	motif 1; other site
400673006177	motif 2; other site
400673006178	active site
400673006179	motif 3; other site
400673006180	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
400673006181	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
400673006182	Walker A/P-loop; other site
400673006183	ATP binding site [chemical binding]; other site
400673006184	Q-loop/lid; other site
400673006185	ABC transporter signature motif; other site
400673006186	Walker B; other site
400673006187	D-loop; other site
400673006188	H-loop/switch region; other site
400673006189	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
400673006190	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
400673006191	FtsX-like permease family; Region: FtsX; pfam02687
400673006192	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
400673006193	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
400673006194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673006195	motif II; other site
400673006196	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
400673006197	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
400673006198	RNA binding surface [nucleotide binding]; other site
400673006199	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
400673006200	active site
400673006201	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
400673006202	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
400673006203	homodimer interface [polypeptide binding]; other site
400673006204	oligonucleotide binding site [chemical binding]; other site
400673006205	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
400673006206	ATP-dependent helicase HepA; Validated; Region: PRK04914
400673006207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673006208	ATP binding site [chemical binding]; other site
400673006209	putative Mg++ binding site [ion binding]; other site
400673006210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673006211	nucleotide binding region [chemical binding]; other site
400673006212	ATP-binding site [chemical binding]; other site
400673006213	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673006214	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
400673006215	Smr domain; Region: Smr; pfam01713
400673006216	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
400673006217	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
400673006218	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
400673006219	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
400673006220	Tetramer interface [polypeptide binding]; other site
400673006221	active site
400673006222	FMN-binding site [chemical binding]; other site
400673006223	HemK family putative methylases; Region: hemK_fam; TIGR00536
400673006224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006225	S-adenosylmethionine binding site [chemical binding]; other site
400673006226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
400673006227	Smr domain; Region: Smr; pfam01713
400673006228	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
400673006229	active site residue [active]
400673006230	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
400673006231	GSH binding site [chemical binding]; other site
400673006232	catalytic residues [active]
400673006233	preprotein translocase subunit SecB; Validated; Region: PRK05751
400673006234	SecA binding site; other site
400673006235	Preprotein binding site; other site
400673006236	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
400673006237	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
400673006238	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
400673006239	glutamate racemase; Provisional; Region: PRK00865
400673006240	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
400673006241	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
400673006242	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
400673006243	dihydrodipicolinate synthase; Region: dapA; TIGR00674
400673006244	dimer interface [polypeptide binding]; other site
400673006245	active site
400673006246	catalytic residue [active]
400673006247	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
400673006248	classical (c) SDRs; Region: SDR_c; cd05233
400673006249	NAD(P) binding site [chemical binding]; other site
400673006250	active site
400673006251	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
400673006252	nucleophile elbow; other site
400673006253	Patatin phospholipase; Region: DUF3734; pfam12536
400673006254	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
400673006255	flagellar motor protein MotA; Validated; Region: PRK09110
400673006256	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
400673006257	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
400673006258	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673006259	ligand binding site [chemical binding]; other site
400673006260	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
400673006261	serine transporter; Region: stp; TIGR00814
400673006262	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
400673006263	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673006264	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
400673006265	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673006266	ATP binding site [chemical binding]; other site
400673006267	Walker B motif; other site
400673006268	sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678
400673006269	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
400673006270	DNA repair protein RadA; Provisional; Region: PRK11823
400673006271	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673006272	Walker A motif; other site
400673006273	ATP binding site [chemical binding]; other site
400673006274	Walker B motif; other site
400673006275	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
400673006276	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
400673006277	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
400673006278	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
400673006279	substrate binding pocket [chemical binding]; other site
400673006280	chain length determination region; other site
400673006281	substrate-Mg2+ binding site; other site
400673006282	catalytic residues [active]
400673006283	aspartate-rich region 1; other site
400673006284	active site lid residues [active]
400673006285	aspartate-rich region 2; other site
400673006286	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
400673006287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006288	S-adenosylmethionine binding site [chemical binding]; other site
400673006289	comF family protein; Region: comF; TIGR00201
400673006290	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
400673006291	active site
400673006292	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
400673006293	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
400673006294	active site
400673006295	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
400673006296	protein binding site [polypeptide binding]; other site
400673006297	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
400673006298	putative substrate binding region [chemical binding]; other site
400673006299	GrpE; Region: GrpE; pfam01025
400673006300	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
400673006301	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
400673006302	tRNA; other site
400673006303	putative tRNA binding site [nucleotide binding]; other site
400673006304	putative NADP binding site [chemical binding]; other site
400673006305	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
400673006306	peptide chain release factor 1; Validated; Region: prfA; PRK00591
400673006307	This domain is found in peptide chain release factors; Region: PCRF; smart00937
400673006308	RF-1 domain; Region: RF-1; pfam00472
400673006309	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
400673006310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006311	S-adenosylmethionine binding site [chemical binding]; other site
400673006312	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
400673006313	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673006314	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
400673006315	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
400673006316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
400673006317	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
400673006318	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
400673006319	putative metal binding site [ion binding]; other site
400673006320	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
400673006321	HSP70 interaction site [polypeptide binding]; other site
400673006322	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
400673006323	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
400673006324	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
400673006325	active site
400673006326	catalytic triad [active]
400673006327	oxyanion hole [active]
400673006328	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
400673006329	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
400673006330	ATP binding site [chemical binding]; other site
400673006331	Mg++ binding site [ion binding]; other site
400673006332	motif III; other site
400673006333	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
400673006334	nucleotide binding region [chemical binding]; other site
400673006335	ATP-binding site [chemical binding]; other site
400673006336	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
400673006337	putative RNA binding site [nucleotide binding]; other site
400673006338	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
400673006339	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
400673006340	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
400673006341	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
400673006342	active site
400673006343	FMN binding site [chemical binding]; other site
400673006344	2,4-decadienoyl-CoA binding site; other site
400673006345	catalytic residue [active]
400673006346	4Fe-4S cluster binding site [ion binding]; other site
400673006347	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
400673006348	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
400673006349	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
400673006350	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
400673006351	E-class dimer interface [polypeptide binding]; other site
400673006352	P-class dimer interface [polypeptide binding]; other site
400673006353	active site
400673006354	Cu2+ binding site [ion binding]; other site
400673006355	Zn2+ binding site [ion binding]; other site
400673006356	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
400673006357	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
400673006358	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
400673006359	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
400673006360	dimer interface [polypeptide binding]; other site
400673006361	decamer (pentamer of dimers) interface [polypeptide binding]; other site
400673006362	catalytic triad [active]
400673006363	peroxidatic and resolving cysteines [active]
400673006364	malate dehydrogenase; Provisional; Region: PRK05442
400673006365	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
400673006366	NAD(P) binding site [chemical binding]; other site
400673006367	dimer interface [polypeptide binding]; other site
400673006368	malate binding site [chemical binding]; other site
400673006369	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
400673006370	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
400673006371	dimer interface [polypeptide binding]; other site
400673006372	ADP-ribose binding site [chemical binding]; other site
400673006373	active site
400673006374	nudix motif; other site
400673006375	metal binding site [ion binding]; metal-binding site
400673006376	HemN family oxidoreductase; Provisional; Region: PRK05660
400673006377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
400673006378	FeS/SAM binding site; other site
400673006379	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
400673006380	Amidase; Region: Amidase; pfam01425
400673006381	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
400673006382	UGMP family protein; Validated; Region: PRK09604
400673006383	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
400673006384	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
400673006385	Yqey-like protein; Region: YqeY; pfam09424
400673006386	DNA primase; Validated; Region: dnaG; PRK05667
400673006387	CHC2 zinc finger; Region: zf-CHC2; pfam01807
400673006388	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
400673006389	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
400673006390	active site
400673006391	metal binding site [ion binding]; metal-binding site
400673006392	interdomain interaction site; other site
400673006393	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
400673006394	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
400673006395	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
400673006396	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
400673006397	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
400673006398	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
400673006399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
400673006400	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
400673006401	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
400673006402	DNA binding residues [nucleotide binding]
400673006403	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
400673006404	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
400673006405	active site
400673006406	DNA binding site [nucleotide binding]
400673006407	Int/Topo IB signature motif; other site
400673006408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673006409	Coenzyme A binding pocket [chemical binding]; other site
400673006410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006411	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673006412	putative substrate translocation pore; other site
400673006413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673006414	Coenzyme A binding pocket [chemical binding]; other site
400673006415	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
400673006416	Serine hydrolase; Region: Ser_hydrolase; cl17834
400673006417	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
400673006418	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
400673006419	DNA binding residues [nucleotide binding]
400673006420	dimerization interface [polypeptide binding]; other site
400673006421	Domain of unknown function DUF302; Region: DUF302; cl01364
400673006422	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673006423	Soluble P-type ATPase [General function prediction only]; Region: COG4087
400673006424	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673006425	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673006426	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673006427	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
400673006428	metal-binding site [ion binding]
400673006429	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673006430	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
400673006431	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
400673006432	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
400673006433	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
400673006434	E3 interaction surface; other site
400673006435	lipoyl attachment site [posttranslational modification]; other site
400673006436	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673006437	Outer membrane efflux protein; Region: OEP; pfam02321
400673006438	Outer membrane efflux protein; Region: OEP; pfam02321
400673006439	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
400673006440	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
400673006441	putative active site [active]
400673006442	putative NTP binding site [chemical binding]; other site
400673006443	putative nucleic acid binding site [nucleotide binding]; other site
400673006444	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
400673006445	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
400673006446	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
400673006447	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
400673006448	active site
400673006449	NTP binding site [chemical binding]; other site
400673006450	nucleic acid binding site [nucleotide binding]; other site
400673006451	Transposase domain (DUF772); Region: DUF772; pfam05598
400673006452	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673006453	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
400673006454	non-specific DNA binding site [nucleotide binding]; other site
400673006455	salt bridge; other site
400673006456	sequence-specific DNA binding site [nucleotide binding]; other site
400673006457	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
400673006458	Catalytic site [active]
400673006459	Global regulator protein family; Region: CsrA; pfam02599
400673006460	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
400673006461	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
400673006462	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
400673006463	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
400673006464	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
400673006465	conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750
400673006466	Protein of unknown function (DUF2895); Region: DUF2895; cl12968
400673006467	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
400673006468	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
400673006469	basic region leucin zipper; Region: BRLZ; smart00338
400673006470	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
400673006471	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
400673006472	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
400673006473	Domain of unknown function DUF87; Region: DUF87; pfam01935
400673006474	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
400673006475	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
400673006476	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
400673006477	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
400673006478	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
400673006479	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
400673006480	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
400673006481	active site
400673006482	catalytic residues [active]
400673006483	DNA binding site [nucleotide binding]
400673006484	Int/Topo IB signature motif; other site
400673006485	Antirestriction protein (ArdA); Region: ArdA; pfam07275
400673006486	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
400673006487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
400673006488	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673006489	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
400673006490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006491	S-adenosylmethionine binding site [chemical binding]; other site
400673006492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
400673006493	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673006494	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
400673006495	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
400673006496	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
400673006497	DNA binding site [nucleotide binding]
400673006498	active site
400673006499	Int/Topo IB signature motif; other site
400673006500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673006501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673006502	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
400673006503	putative effector binding pocket; other site
400673006504	dimerization interface [polypeptide binding]; other site
400673006505	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
400673006506	Cupin domain; Region: Cupin_2; cl17218
400673006507	hypothetical protein; Provisional; Region: PRK07206
400673006508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673006509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673006510	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
400673006511	substrate binding pocket [chemical binding]; other site
400673006512	dimerization interface [polypeptide binding]; other site
400673006513	potential frameshift: common BLAST hit: gi|52842578|ref|YP_096377.1| HipA (persistence to inhibition of murein or DNA biosynthesis)
400673006514	HipA N-terminal domain; Region: Couple_hipA; cl11853
400673006515	HipA N-terminal domain; Region: Couple_hipA; cl11853
400673006516	HipA-like N-terminal domain; Region: HipA_N; pfam07805
400673006517	HipA-like C-terminal domain; Region: HipA_C; pfam07804
400673006518	Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; Region: t_SNARE; cd00193
400673006519	flanking leucine-zipper layers; other site
400673006520	zero layer; other site
400673006521	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673006522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673006523	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
400673006524	putative effector binding pocket; other site
400673006525	dimerization interface [polypeptide binding]; other site
400673006526	Protein required for attachment to host cells; Region: Host_attach; pfam10116
400673006527	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
400673006528	putative FMN binding site [chemical binding]; other site
400673006529	NADPH bind site [chemical binding]; other site
400673006530	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
400673006531	potassium uptake protein; Region: kup; TIGR00794
400673006532	K+ potassium transporter; Region: K_trans; pfam02705
400673006533	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
400673006534	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
400673006535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673006536	NAD(P) binding site [chemical binding]; other site
400673006537	active site
400673006538	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
400673006539	Ligand Binding Site [chemical binding]; other site
400673006540	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
400673006541	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
400673006542	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673006543	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
400673006544	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
400673006545	Soluble P-type ATPase [General function prediction only]; Region: COG4087
400673006546	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
400673006547	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
400673006548	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
400673006549	TrkA-N domain; Region: TrkA_N; pfam02254
400673006550	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
400673006551	Ligand Binding Site [chemical binding]; other site
400673006552	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
400673006553	Ligand Binding Site [chemical binding]; other site
400673006554	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
400673006555	AAA domain; Region: AAA_18; pfam13238
400673006556	active site
400673006557	outer membrane protease; Reviewed; Region: PRK10993
400673006558	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
400673006559	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
400673006560	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
400673006561	dimer interface [polypeptide binding]; other site
400673006562	active site
400673006563	heme binding site [chemical binding]; other site
400673006564	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
400673006565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006566	metabolite-proton symporter; Region: 2A0106; TIGR00883
400673006567	putative substrate translocation pore; other site
400673006568	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
400673006569	Substrate binding site [chemical binding]; other site
400673006570	Ferritin-like domain; Region: Ferritin; pfam00210
400673006571	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
400673006572	dinuclear metal binding motif [ion binding]; other site
400673006573	Methyltransferase domain; Region: Methyltransf_31; pfam13847
400673006574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006575	S-adenosylmethionine binding site [chemical binding]; other site
400673006576	OsmC-like protein; Region: OsmC; pfam02566
400673006577	Peptidase family M23; Region: Peptidase_M23; pfam01551
400673006578	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
400673006579	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
400673006580	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
400673006581	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
400673006582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
400673006583	Beta-lactamase; Region: Beta-lactamase; pfam00144
400673006584	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
400673006585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
400673006586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
400673006587	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
400673006588	putative substrate binding pocket [chemical binding]; other site
400673006589	putative dimerization interface [polypeptide binding]; other site
400673006590	Cytochrome P450; Region: p450; cl12078
400673006591	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
400673006592	nudix motif; other site
400673006593	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
400673006594	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
400673006595	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
400673006596	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
400673006597	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
400673006598	GAF domain; Region: GAF_3; pfam13492
400673006599	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673006600	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673006601	metal binding site [ion binding]; metal-binding site
400673006602	active site
400673006603	I-site; other site
400673006604	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
400673006605	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
400673006606	active site
400673006607	nucleophile elbow; other site
400673006608	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
400673006609	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
400673006610	Ras GTPase Activating Domain; Region: RasGAP; cl02569
400673006611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673006612	Coenzyme A binding pocket [chemical binding]; other site
400673006613	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
400673006614	Coenzyme A transferase; Region: CoA_trans; cl17247
400673006615	malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130
400673006616	malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133
400673006617	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
400673006618	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
400673006619	malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135
400673006620	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
400673006621	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
400673006622	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
400673006623	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
400673006624	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
400673006625	active site
400673006626	metal binding site [ion binding]; metal-binding site
400673006627	Cupin domain; Region: Cupin_2; cl17218
400673006628	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
400673006629	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
400673006630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006631	putative substrate translocation pore; other site
400673006632	Predicted flavoprotein [General function prediction only]; Region: COG0431
400673006633	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
400673006634	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
400673006635	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
400673006636	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
400673006637	putative dimer interface [polypeptide binding]; other site
400673006638	N-terminal domain interface [polypeptide binding]; other site
400673006639	putative substrate binding pocket (H-site) [chemical binding]; other site
400673006640	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
400673006641	dimer interface [polypeptide binding]; other site
400673006642	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
400673006643	dimer interface [polypeptide binding]; other site
400673006644	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
400673006645	N-acetyltransferase; Region: Acetyltransf_2; cl00949
400673006646	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
400673006647	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
400673006648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
400673006649	Coenzyme A binding pocket [chemical binding]; other site
400673006650	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
400673006651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673006652	active site
400673006653	phosphorylation site [posttranslational modification]
400673006654	intermolecular recognition site; other site
400673006655	dimerization interface [polypeptide binding]; other site
400673006656	PAS domain S-box; Region: sensory_box; TIGR00229
400673006657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673006658	putative active site [active]
400673006659	heme pocket [chemical binding]; other site
400673006660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673006661	dimer interface [polypeptide binding]; other site
400673006662	phosphorylation site [posttranslational modification]
400673006663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673006664	ATP binding site [chemical binding]; other site
400673006665	Mg2+ binding site [ion binding]; other site
400673006666	G-X-G motif; other site
400673006667	Heme NO binding; Region: HNOB; pfam07700
400673006668	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
400673006669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006670	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
400673006671	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
400673006672	nickel binding site [ion binding]; other site
400673006673	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
400673006674	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
400673006675	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
400673006676	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
400673006677	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
400673006678	FAD binding pocket [chemical binding]; other site
400673006679	FAD binding motif [chemical binding]; other site
400673006680	phosphate binding motif [ion binding]; other site
400673006681	beta-alpha-beta structure motif; other site
400673006682	NAD binding pocket [chemical binding]; other site
400673006683	Iron coordination center [ion binding]; other site
400673006684	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
400673006685	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
400673006686	dimerization interface [polypeptide binding]; other site
400673006687	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
400673006688	ATP binding site [chemical binding]; other site
400673006689	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
400673006690	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
400673006691	HupF/HypC family; Region: HupF_HypC; pfam01455
400673006692	Acylphosphatase; Region: Acylphosphatase; pfam00708
400673006693	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
400673006694	HypF finger; Region: zf-HYPF; pfam07503
400673006695	HypF finger; Region: zf-HYPF; pfam07503
400673006696	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
400673006697	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
400673006698	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
400673006699	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
400673006700	High-affinity nickel-transport protein; Region: NicO; cl00964
400673006701	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
400673006702	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
400673006703	Ligand binding site; other site
400673006704	Putative Catalytic site; other site
400673006705	DXD motif; other site
400673006706	GtrA-like protein; Region: GtrA; pfam04138
400673006707	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
400673006708	putative active site [active]
400673006709	YdjC motif; other site
400673006710	Mg binding site [ion binding]; other site
400673006711	putative homodimer interface [polypeptide binding]; other site
400673006712	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
400673006713	EamA-like transporter family; Region: EamA; pfam00892
400673006714	EamA-like transporter family; Region: EamA; pfam00892
400673006715	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673006716	Uncharacterized conserved protein [Function unknown]; Region: COG2128
400673006717	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
400673006718	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
400673006719	active site
400673006720	dimerization interface [polypeptide binding]; other site
400673006721	TPR repeat; Region: TPR_11; pfam13414
400673006722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673006723	binding surface
400673006724	TPR motif; other site
400673006725	TPR repeat; Region: TPR_11; pfam13414
400673006726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673006727	binding surface
400673006728	TPR repeat; Region: TPR_11; pfam13414
400673006729	TPR motif; other site
400673006730	TPR repeat; Region: TPR_11; pfam13414
400673006731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673006732	binding surface
400673006733	TPR repeat; Region: TPR_11; pfam13414
400673006734	TPR motif; other site
400673006735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673006736	binding surface
400673006737	TPR motif; other site
400673006738	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
400673006739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
400673006740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006741	S-adenosylmethionine binding site [chemical binding]; other site
400673006742	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
400673006743	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
400673006744	active site
400673006745	substrate binding site [chemical binding]; other site
400673006746	metal binding site [ion binding]; metal-binding site
400673006747	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
400673006748	trimer interface [polypeptide binding]; other site
400673006749	active site
400673006750	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
400673006751	Flavoprotein; Region: Flavoprotein; pfam02441
400673006752	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
400673006753	hypothetical protein; Reviewed; Region: PRK00024
400673006754	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
400673006755	MPN+ (JAMM) motif; other site
400673006756	Zinc-binding site [ion binding]; other site
400673006757	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
400673006758	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
400673006759	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
400673006760	FOG: CBS domain [General function prediction only]; Region: COG0517
400673006761	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
400673006762	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
400673006763	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
400673006764	putative NAD(P) binding site [chemical binding]; other site
400673006765	putative substrate binding site [chemical binding]; other site
400673006766	catalytic Zn binding site [ion binding]; other site
400673006767	structural Zn binding site [ion binding]; other site
400673006768	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
400673006769	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
400673006770	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
400673006771	putative dimer interface [polypeptide binding]; other site
400673006772	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
400673006773	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
400673006774	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
400673006775	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
400673006776	Thiamine pyrophosphokinase; Region: TPK; cd07995
400673006777	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
400673006778	active site
400673006779	dimerization interface [polypeptide binding]; other site
400673006780	thiamine binding site [chemical binding]; other site
400673006781	PQ loop repeat; Region: PQ-loop; pfam04193
400673006782	LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861
400673006783	nucleotide binding site [chemical binding]; other site
400673006784	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
400673006785	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
400673006786	active site clefts [active]
400673006787	zinc binding site [ion binding]; other site
400673006788	dimer interface [polypeptide binding]; other site
400673006789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673006791	putative substrate translocation pore; other site
400673006792	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
400673006793	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
400673006794	dimer interface [polypeptide binding]; other site
400673006795	phosphorylation site [posttranslational modification]
400673006796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673006797	ATP binding site [chemical binding]; other site
400673006798	Mg2+ binding site [ion binding]; other site
400673006799	G-X-G motif; other site
400673006800	Dot/Icm substrate protein; Region: SidE; pfam12252
400673006801	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
400673006802	Protein export membrane protein; Region: SecD_SecF; cl14618
400673006803	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673006804	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673006805	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673006806	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
400673006807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
400673006808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006809	putative substrate translocation pore; other site
400673006810	Major Facilitator Superfamily; Region: MFS_1; pfam07690
400673006811	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
400673006812	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
400673006813	putative DNA binding site [nucleotide binding]; other site
400673006814	putative Zn2+ binding site [ion binding]; other site
400673006815	AsnC family; Region: AsnC_trans_reg; pfam01037
400673006816	MutS2 family protein; Region: mutS2; TIGR01069
400673006817	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
400673006818	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
400673006819	dimer interface [polypeptide binding]; other site
400673006820	active site
400673006821	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
400673006822	substrate binding site [chemical binding]; other site
400673006823	catalytic residue [active]
400673006824	Prohead core protein protease; Region: Peptidase_U9; cl11614
400673006825	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
400673006826	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
400673006827	active site
400673006828	catalytic site [active]
400673006829	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
400673006830	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
400673006831	Prephenate dehydratase; Region: PDT; pfam00800
400673006832	Chorismate mutase type II; Region: CM_2; smart00830
400673006833	aspartate aminotransferase; Provisional; Region: PRK05764
400673006834	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
400673006835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673006836	homodimer interface [polypeptide binding]; other site
400673006837	catalytic residue [active]
400673006838	tellurite resistance protein TehB; Provisional; Region: PRK12335
400673006839	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
400673006840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006841	S-adenosylmethionine binding site [chemical binding]; other site
400673006842	Transcriptional regulator; Region: Rrf2; cl17282
400673006843	Rrf2 family protein; Region: rrf2_super; TIGR00738
400673006844	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
400673006845	apolar tunnel; other site
400673006846	heme binding site [chemical binding]; other site
400673006847	dimerization interface [polypeptide binding]; other site
400673006848	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
400673006849	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
400673006850	catalytic loop [active]
400673006851	iron binding site [ion binding]; other site
400673006852	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
400673006853	FAD binding pocket [chemical binding]; other site
400673006854	FAD binding motif [chemical binding]; other site
400673006855	phosphate binding motif [ion binding]; other site
400673006856	beta-alpha-beta structure motif; other site
400673006857	NAD binding pocket [chemical binding]; other site
400673006858	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
400673006859	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
400673006860	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
400673006861	MltA specific insert domain; Region: MltA; cl08398
400673006862	3D domain; Region: 3D; pfam06725
400673006863	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
400673006864	dimer interface [polypeptide binding]; other site
400673006865	putative tRNA-binding site [nucleotide binding]; other site
400673006866	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
400673006867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
400673006868	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
400673006869	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
400673006870	putative active site pocket [active]
400673006871	dimerization interface [polypeptide binding]; other site
400673006872	putative catalytic residue [active]
400673006873	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
400673006874	EamA-like transporter family; Region: EamA; pfam00892
400673006875	EamA-like transporter family; Region: EamA; pfam00892
400673006876	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
400673006877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673006878	putative substrate translocation pore; other site
400673006879	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
400673006880	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
400673006881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
400673006882	active site
400673006883	motif I; other site
400673006884	motif II; other site
400673006885	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
400673006886	Catalytic domain of Protein Kinases; Region: PKc; cd00180
400673006887	active site
400673006888	ATP binding site [chemical binding]; other site
400673006889	substrate binding site [chemical binding]; other site
400673006890	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
400673006891	substrate binding site [chemical binding]; other site
400673006892	activation loop (A-loop); other site
400673006893	activation loop (A-loop); other site
400673006894	PAS domain; Region: PAS_9; pfam13426
400673006895	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
400673006896	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
400673006897	DNA binding residues [nucleotide binding]
400673006898	dimerization interface [polypeptide binding]; other site
400673006899	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
400673006900	HSP70 interaction site [polypeptide binding]; other site
400673006901	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
400673006902	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
400673006903	putative active site [active]
400673006904	putative NTP binding site [chemical binding]; other site
400673006905	putative nucleic acid binding site [nucleotide binding]; other site
400673006906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673006907	sequence-specific DNA binding site [nucleotide binding]; other site
400673006908	salt bridge; other site
400673006909	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
400673006910	Integrase; Region: Integrase_1; pfam12835
400673006911	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
400673006912	Transposase; Region: DDE_Tnp_ISL3; pfam01610
400673006913	Uncharacterized conserved protein [Function unknown]; Region: COG3189
400673006914	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
400673006915	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
400673006916	active site
400673006917	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
400673006918	tetramer interface [polypeptide binding]; other site
400673006919	TPP-binding site [chemical binding]; other site
400673006920	heterodimer interface [polypeptide binding]; other site
400673006921	phosphorylation loop region [posttranslational modification]
400673006922	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
400673006923	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
400673006924	PYR/PP interface [polypeptide binding]; other site
400673006925	dimer interface [polypeptide binding]; other site
400673006926	TPP binding site [chemical binding]; other site
400673006927	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
400673006928	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
400673006929	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
400673006930	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
400673006931	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
400673006932	active site
400673006933	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
400673006934	active site
400673006935	catalytic triad [active]
400673006936	oxyanion hole [active]
400673006937	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
400673006938	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
400673006939	active site
400673006940	metal binding site [ion binding]; metal-binding site
400673006941	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
400673006942	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
400673006943	ParB-like nuclease domain; Region: ParBc; pfam02195
400673006944	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
400673006945	16S rRNA methyltransferase B; Provisional; Region: PRK10901
400673006946	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
400673006947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673006948	S-adenosylmethionine binding site [chemical binding]; other site
400673006949	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
400673006950	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
400673006951	putative active site [active]
400673006952	substrate binding site [chemical binding]; other site
400673006953	putative cosubstrate binding site; other site
400673006954	catalytic site [active]
400673006955	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
400673006956	substrate binding site [chemical binding]; other site
400673006957	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
400673006958	active site
400673006959	catalytic residues [active]
400673006960	metal binding site [ion binding]; metal-binding site
400673006961	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
400673006962	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673006963	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
400673006964	DNA protecting protein DprA; Region: dprA; TIGR00732
400673006965	Protein of unknown function (DUF494); Region: DUF494; pfam04361
400673006966	DNA topoisomerase I; Validated; Region: PRK06599
400673006967	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
400673006968	active site
400673006969	interdomain interaction site; other site
400673006970	putative metal-binding site [ion binding]; other site
400673006971	nucleotide binding site [chemical binding]; other site
400673006972	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
400673006973	domain I; other site
400673006974	DNA binding groove [nucleotide binding]
400673006975	phosphate binding site [ion binding]; other site
400673006976	domain II; other site
400673006977	domain III; other site
400673006978	nucleotide binding site [chemical binding]; other site
400673006979	catalytic site [active]
400673006980	domain IV; other site
400673006981	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
400673006982	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
400673006983	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
400673006984	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
400673006985	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
400673006986	Bacterial PH domain; Region: DUF304; pfam03703
400673006987	Protein of unknown function (DUF721); Region: DUF721; pfam05258
400673006988	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
400673006989	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
400673006990	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
400673006991	Uncharacterized conserved protein [Function unknown]; Region: COG4278
400673006992	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
400673006993	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
400673006994	putative active site [active]
400673006995	putative dimer interface [polypeptide binding]; other site
400673006996	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
400673006997	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
400673006998	active site
400673006999	Zn binding site [ion binding]; other site
400673007000	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
400673007001	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
400673007002	cell division protein FtsZ; Validated; Region: PRK09330
400673007003	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
400673007004	nucleotide binding site [chemical binding]; other site
400673007005	SulA interaction site; other site
400673007006	cell division protein FtsA; Region: ftsA; TIGR01174
400673007007	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
400673007008	nucleotide binding site [chemical binding]; other site
400673007009	Cell division protein FtsA; Region: FtsA; pfam14450
400673007010	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
400673007011	Cell division protein FtsQ; Region: FtsQ; pfam03799
400673007012	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
400673007013	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
400673007014	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673007015	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
400673007016	FAD binding domain; Region: FAD_binding_4; pfam01565
400673007017	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
400673007018	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
400673007019	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
400673007020	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
400673007021	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673007022	cell division protein FtsW; Region: ftsW; TIGR02614
400673007023	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
400673007024	TrkA-N domain; Region: TrkA_N; pfam02254
400673007025	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
400673007026	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673007027	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
400673007028	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
400673007029	Mg++ binding site [ion binding]; other site
400673007030	putative catalytic motif [active]
400673007031	putative substrate binding site [chemical binding]; other site
400673007032	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
400673007033	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
400673007034	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
400673007035	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
400673007036	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
400673007037	FtsZ protein binding site [polypeptide binding]; other site
400673007038	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
400673007039	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
400673007040	Walker A/P-loop; other site
400673007041	ATP binding site [chemical binding]; other site
400673007042	Q-loop/lid; other site
400673007043	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
400673007044	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
400673007045	Q-loop/lid; other site
400673007046	ABC transporter signature motif; other site
400673007047	Walker B; other site
400673007048	D-loop; other site
400673007049	H-loop/switch region; other site
400673007050	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767
400673007051	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
400673007052	active site
400673007053	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
400673007054	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
400673007055	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
400673007056	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
400673007057	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
400673007058	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
400673007059	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
400673007060	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
400673007061	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
400673007062	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673007063	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
400673007064	IMP binding site; other site
400673007065	dimer interface [polypeptide binding]; other site
400673007066	interdomain contacts; other site
400673007067	partial ornithine binding site; other site
400673007068	Predicted flavoproteins [General function prediction only]; Region: COG2081
400673007069	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
400673007070	Uncharacterized conserved protein [Function unknown]; Region: COG1434
400673007071	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
400673007072	putative active site [active]
400673007073	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
400673007074	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
400673007075	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
400673007076	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
400673007077	multifunctional aminopeptidase A; Provisional; Region: PRK00913
400673007078	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
400673007079	interface (dimer of trimers) [polypeptide binding]; other site
400673007080	Substrate-binding/catalytic site; other site
400673007081	Zn-binding sites [ion binding]; other site
400673007082	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
400673007083	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
400673007084	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
400673007085	interface (dimer of trimers) [polypeptide binding]; other site
400673007086	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
400673007087	Substrate-binding/catalytic site; other site
400673007088	Zn-binding sites [ion binding]; other site
400673007089	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
400673007090	MviN-like protein; Region: MVIN; pfam03023
400673007091	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
400673007092	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673007093	Sel1-like repeats; Region: SEL1; smart00671
400673007094	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673007095	Sel1-like repeats; Region: SEL1; smart00671
400673007096	Sel1-like repeats; Region: SEL1; smart00671
400673007097	Sel1-like repeats; Region: SEL1; smart00671
400673007098	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
400673007099	Sel1-like repeats; Region: SEL1; smart00671
400673007100	Sel1-like repeats; Region: SEL1; smart00671
400673007101	Sel1-like repeats; Region: SEL1; smart00671
400673007102	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
400673007103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
400673007104	putative active site [active]
400673007105	GAF domain; Region: GAF; pfam01590
400673007106	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673007107	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673007108	metal binding site [ion binding]; metal-binding site
400673007109	active site
400673007110	I-site; other site
400673007111	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
400673007112	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
400673007113	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
400673007114	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
400673007115	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
400673007116	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
400673007117	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
400673007118	GIY-YIG motif/motif A; other site
400673007119	active site
400673007120	catalytic site [active]
400673007121	putative DNA binding site [nucleotide binding]; other site
400673007122	metal binding site [ion binding]; metal-binding site
400673007123	UvrB/uvrC motif; Region: UVR; pfam02151
400673007124	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
400673007125	response regulator; Provisional; Region: PRK09483
400673007126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673007127	active site
400673007128	phosphorylation site [posttranslational modification]
400673007129	intermolecular recognition site; other site
400673007130	dimerization interface [polypeptide binding]; other site
400673007131	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
400673007132	DNA binding residues [nucleotide binding]
400673007133	dimerization interface [polypeptide binding]; other site
400673007134	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
400673007135	cofactor binding site; other site
400673007136	metal binding site [ion binding]; metal-binding site
400673007137	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
400673007138	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
400673007139	putative MPT binding site; other site
400673007140	GTPase CgtA; Reviewed; Region: obgE; PRK12299
400673007141	GTP1/OBG; Region: GTP1_OBG; pfam01018
400673007142	Obg GTPase; Region: Obg; cd01898
400673007143	G1 box; other site
400673007144	GTP/Mg2+ binding site [chemical binding]; other site
400673007145	Switch I region; other site
400673007146	G2 box; other site
400673007147	G3 box; other site
400673007148	Switch II region; other site
400673007149	G4 box; other site
400673007150	G5 box; other site
400673007151	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
400673007152	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
400673007153	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
400673007154	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
400673007155	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
400673007156	5S rRNA interface [nucleotide binding]; other site
400673007157	CTC domain interface [polypeptide binding]; other site
400673007158	L16 interface [polypeptide binding]; other site
400673007159	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
400673007160	putative active site [active]
400673007161	catalytic residue [active]
400673007162	GTP-binding protein YchF; Reviewed; Region: PRK09601
400673007163	YchF GTPase; Region: YchF; cd01900
400673007164	G1 box; other site
400673007165	GTP/Mg2+ binding site [chemical binding]; other site
400673007166	Switch I region; other site
400673007167	G2 box; other site
400673007168	Switch II region; other site
400673007169	G3 box; other site
400673007170	G4 box; other site
400673007171	G5 box; other site
400673007172	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
400673007173	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
400673007174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
400673007175	metal binding site [ion binding]; metal-binding site
400673007176	active site
400673007177	I-site; other site
400673007178	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
400673007179	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
400673007180	substrate binding pocket [chemical binding]; other site
400673007181	chain length determination region; other site
400673007182	substrate-Mg2+ binding site; other site
400673007183	catalytic residues [active]
400673007184	aspartate-rich region 1; other site
400673007185	active site lid residues [active]
400673007186	aspartate-rich region 2; other site
400673007187	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
400673007188	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
400673007189	G1 box; other site
400673007190	GTP/Mg2+ binding site [chemical binding]; other site
400673007191	Switch I region; other site
400673007192	G2 box; other site
400673007193	G3 box; other site
400673007194	Switch II region; other site
400673007195	G4 box; other site
400673007196	G5 box; other site
400673007197	Nucleoside recognition; Region: Gate; pfam07670
400673007198	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
400673007199	Nucleoside recognition; Region: Gate; pfam07670
400673007200	FeoA domain; Region: FeoA; pfam04023
400673007201	Predicted ATPase [General function prediction only]; Region: COG1485
400673007202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
400673007203	Walker A motif; other site
400673007204	ATP binding site [chemical binding]; other site
400673007205	Walker B motif; other site
400673007206	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
400673007207	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
400673007208	oligomerization interface [polypeptide binding]; other site
400673007209	active site
400673007210	metal binding site [ion binding]; metal-binding site
400673007211	pantoate--beta-alanine ligase; Region: panC; TIGR00018
400673007212	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
400673007213	active site
400673007214	nucleotide binding site [chemical binding]; other site
400673007215	HIGH motif; other site
400673007216	KMSKS motif; other site
400673007217	AAA domain; Region: AAA_28; pfam13521
400673007218	Predicted ATPase [General function prediction only]; Region: COG3911
400673007219	pyruvate carboxylase subunit A; Validated; Region: PRK07178
400673007220	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
400673007221	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
400673007222	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
400673007223	Dienelactone hydrolase family; Region: DLH; pfam01738
400673007224	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
400673007225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673007226	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
400673007227	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
400673007228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
400673007229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
400673007230	DNA binding residues [nucleotide binding]
400673007231	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
400673007232	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
400673007233	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
400673007234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673007235	Walker A/P-loop; other site
400673007236	ATP binding site [chemical binding]; other site
400673007237	Q-loop/lid; other site
400673007238	ABC transporter signature motif; other site
400673007239	Walker B; other site
400673007240	D-loop; other site
400673007241	H-loop/switch region; other site
400673007242	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
400673007243	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
400673007244	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
400673007245	P loop; other site
400673007246	GTP binding site [chemical binding]; other site
400673007247	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
400673007248	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
400673007249	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
400673007250	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
400673007251	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
400673007252	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
400673007253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007254	S-adenosylmethionine binding site [chemical binding]; other site
400673007255	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
400673007256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
400673007257	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
400673007258	Walker A motif; other site
400673007259	Walker A/P-loop; other site
400673007260	ATP binding site [chemical binding]; other site
400673007261	ATP binding site [chemical binding]; other site
400673007262	Walker B motif; other site
400673007263	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
400673007264	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
400673007265	putative active site [active]
400673007266	putative metal binding site [ion binding]; other site
400673007267	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
400673007268	Methyltransferase domain; Region: Methyltransf_23; pfam13489
400673007269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007270	S-adenosylmethionine binding site [chemical binding]; other site
400673007271	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
400673007272	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
400673007273	NAD binding site [chemical binding]; other site
400673007274	ATP-grasp domain; Region: ATP-grasp_4; cl17255
400673007275	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
400673007276	active site
400673007277	catalytic residues [active]
400673007278	metal binding site [ion binding]; metal-binding site
400673007279	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
400673007280	tartrate dehydrogenase; Region: TTC; TIGR02089
400673007281	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
400673007282	Dienelactone hydrolase family; Region: DLH; pfam01738
400673007283	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
400673007284	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
400673007285	Phagosome trafficking protein DotA; Region: DotA; pfam11388
400673007286	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
400673007287	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
400673007288	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
400673007289	metal-binding site [ion binding]
400673007290	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
400673007291	Methyltransferase domain; Region: Methyltransf_31; pfam13847
400673007292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007293	S-adenosylmethionine binding site [chemical binding]; other site
400673007294	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
400673007295	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
400673007296	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
400673007297	putative active site [active]
400673007298	Zinc-finger domain; Region: zf-CHCC; cl01821
400673007299	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
400673007300	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
400673007301	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
400673007302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673007303	ATP binding site [chemical binding]; other site
400673007304	Mg2+ binding site [ion binding]; other site
400673007305	G-X-G motif; other site
400673007306	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
400673007307	ATP binding site [chemical binding]; other site
400673007308	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
400673007309	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
400673007310	AMIN domain; Region: AMIN; pfam11741
400673007311	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
400673007312	active site
400673007313	metal binding site [ion binding]; metal-binding site
400673007314	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
400673007315	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
400673007316	putative carbohydrate kinase; Provisional; Region: PRK10565
400673007317	Uncharacterized conserved protein [Function unknown]; Region: COG0062
400673007318	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
400673007319	putative substrate binding site [chemical binding]; other site
400673007320	putative ATP binding site [chemical binding]; other site
400673007321	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
400673007322	stringent starvation protein A; Provisional; Region: sspA; PRK09481
400673007323	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
400673007324	C-terminal domain interface [polypeptide binding]; other site
400673007325	putative GSH binding site (G-site) [chemical binding]; other site
400673007326	dimer interface [polypeptide binding]; other site
400673007327	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
400673007328	dimer interface [polypeptide binding]; other site
400673007329	N-terminal domain interface [polypeptide binding]; other site
400673007330	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
400673007331	cytochrome b; Provisional; Region: CYTB; MTH00145
400673007332	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
400673007333	Qi binding site; other site
400673007334	intrachain domain interface; other site
400673007335	interchain domain interface [polypeptide binding]; other site
400673007336	heme bH binding site [chemical binding]; other site
400673007337	heme bL binding site [chemical binding]; other site
400673007338	Qo binding site; other site
400673007339	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
400673007340	interchain domain interface [polypeptide binding]; other site
400673007341	intrachain domain interface; other site
400673007342	Qi binding site; other site
400673007343	Qo binding site; other site
400673007344	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
400673007345	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
400673007346	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
400673007347	[2Fe-2S] cluster binding site [ion binding]; other site
400673007348	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
400673007349	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
400673007350	23S rRNA interface [nucleotide binding]; other site
400673007351	L3 interface [polypeptide binding]; other site
400673007352	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
400673007353	dimer interface [polypeptide binding]; other site
400673007354	[2Fe-2S] cluster binding site [ion binding]; other site
400673007355	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
400673007356	IHF - DNA interface [nucleotide binding]; other site
400673007357	IHF dimer interface [polypeptide binding]; other site
400673007358	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
400673007359	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
400673007360	putative tRNA-binding site [nucleotide binding]; other site
400673007361	B3/4 domain; Region: B3_4; pfam03483
400673007362	tRNA synthetase B5 domain; Region: B5; pfam03484
400673007363	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
400673007364	dimer interface [polypeptide binding]; other site
400673007365	motif 1; other site
400673007366	motif 3; other site
400673007367	motif 2; other site
400673007368	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
400673007369	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
400673007370	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
400673007371	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
400673007372	dimer interface [polypeptide binding]; other site
400673007373	motif 1; other site
400673007374	active site
400673007375	motif 2; other site
400673007376	motif 3; other site
400673007377	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
400673007378	23S rRNA binding site [nucleotide binding]; other site
400673007379	L21 binding site [polypeptide binding]; other site
400673007380	L13 binding site [polypeptide binding]; other site
400673007381	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
400673007382	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
400673007383	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
400673007384	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
400673007385	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
400673007386	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
400673007387	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
400673007388	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
400673007389	active site
400673007390	dimer interface [polypeptide binding]; other site
400673007391	motif 1; other site
400673007392	motif 2; other site
400673007393	motif 3; other site
400673007394	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
400673007395	anticodon binding site; other site
400673007396	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
400673007397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
400673007398	non-specific DNA binding site [nucleotide binding]; other site
400673007399	salt bridge; other site
400673007400	sequence-specific DNA binding site [nucleotide binding]; other site
400673007401	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
400673007402	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
400673007403	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673007404	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673007405	ligand binding site [chemical binding]; other site
400673007406	flexible hinge region; other site
400673007407	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673007408	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673007409	ligand binding site [chemical binding]; other site
400673007410	flexible hinge region; other site
400673007411	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
400673007412	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
400673007413	putative active site [active]
400673007414	putative dimer interface [polypeptide binding]; other site
400673007415	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
400673007416	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
400673007417	FMN binding site [chemical binding]; other site
400673007418	active site
400673007419	substrate binding site [chemical binding]; other site
400673007420	catalytic residue [active]
400673007421	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
400673007422	dimerization interface [polypeptide binding]; other site
400673007423	putative DNA binding site [nucleotide binding]; other site
400673007424	putative Zn2+ binding site [ion binding]; other site
400673007425	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
400673007426	Predicted membrane protein [Function unknown]; Region: COG2860
400673007427	UPF0126 domain; Region: UPF0126; pfam03458
400673007428	UPF0126 domain; Region: UPF0126; pfam03458
400673007429	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
400673007430	substrate binding site [chemical binding]; other site
400673007431	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
400673007432	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
400673007433	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
400673007434	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
400673007435	hypothetical protein; Provisional; Region: PRK07179
400673007436	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
400673007437	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
400673007438	catalytic residue [active]
400673007439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673007440	active site
400673007441	phosphorylation site [posttranslational modification]
400673007442	intermolecular recognition site; other site
400673007443	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
400673007444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
400673007445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
400673007446	ATP binding site [chemical binding]; other site
400673007447	Mg2+ binding site [ion binding]; other site
400673007448	G-X-G motif; other site
400673007449	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
400673007450	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
400673007451	domain interfaces; other site
400673007452	active site
400673007453	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
400673007454	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
400673007455	active site
400673007456	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
400673007457	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
400673007458	HemY protein N-terminus; Region: HemY_N; pfam07219
400673007459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673007460	TPR motif; other site
400673007461	binding surface
400673007462	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
400673007463	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
400673007464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
400673007465	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
400673007466	catalytic site [active]
400673007467	putative active site [active]
400673007468	putative substrate binding site [chemical binding]; other site
400673007469	dimer interface [polypeptide binding]; other site
400673007470	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
400673007471	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
400673007472	active site
400673007473	NTP binding site [chemical binding]; other site
400673007474	metal binding triad [ion binding]; metal-binding site
400673007475	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
400673007476	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
400673007477	Zn2+ binding site [ion binding]; other site
400673007478	Mg2+ binding site [ion binding]; other site
400673007479	GTPase RsgA; Reviewed; Region: PRK12288
400673007480	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
400673007481	RNA binding site [nucleotide binding]; other site
400673007482	homodimer interface [polypeptide binding]; other site
400673007483	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
400673007484	GTPase/Zn-binding domain interface [polypeptide binding]; other site
400673007485	GTP/Mg2+ binding site [chemical binding]; other site
400673007486	G4 box; other site
400673007487	G5 box; other site
400673007488	G1 box; other site
400673007489	Switch I region; other site
400673007490	G2 box; other site
400673007491	G3 box; other site
400673007492	Switch II region; other site
400673007493	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
400673007494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673007495	Walker A motif; other site
400673007496	ATP binding site [chemical binding]; other site
400673007497	Walker B motif; other site
400673007498	arginine finger; other site
400673007499	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
400673007500	hypothetical protein; Validated; Region: PRK00153
400673007501	recombination protein RecR; Reviewed; Region: recR; PRK00076
400673007502	RecR protein; Region: RecR; pfam02132
400673007503	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
400673007504	putative active site [active]
400673007505	putative metal-binding site [ion binding]; other site
400673007506	tetramer interface [polypeptide binding]; other site
400673007507	Protein of unknown function, DUF547; Region: DUF547; pfam04784
400673007508	Sulfatase; Region: Sulfatase; cl17466
400673007509	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
400673007510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
400673007511	active site
400673007512	dimerization interface [polypeptide binding]; other site
400673007513	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
400673007514	DNA binding site [nucleotide binding]
400673007515	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
400673007516	Domain of unknown function DUF21; Region: DUF21; pfam01595
400673007517	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
400673007518	Transporter associated domain; Region: CorC_HlyC; smart01091
400673007519	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
400673007520	dimer interface [polypeptide binding]; other site
400673007521	substrate binding site [chemical binding]; other site
400673007522	metal binding sites [ion binding]; metal-binding site
400673007523	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
400673007524	nucleotide binding site/active site [active]
400673007525	HIT family signature motif; other site
400673007526	catalytic residue [active]
400673007527	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
400673007528	GTP cyclohydrolase I; Provisional; Region: PLN03044
400673007529	homodecamer interface [polypeptide binding]; other site
400673007530	active site
400673007531	putative catalytic site residues [active]
400673007532	zinc binding site [ion binding]; other site
400673007533	GTP-CH-I/GFRP interaction surface; other site
400673007534	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
400673007535	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
400673007536	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
400673007537	RNase E interface [polypeptide binding]; other site
400673007538	trimer interface [polypeptide binding]; other site
400673007539	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
400673007540	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
400673007541	RNase E interface [polypeptide binding]; other site
400673007542	trimer interface [polypeptide binding]; other site
400673007543	active site
400673007544	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
400673007545	putative nucleic acid binding region [nucleotide binding]; other site
400673007546	G-X-X-G motif; other site
400673007547	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
400673007548	RNA binding site [nucleotide binding]; other site
400673007549	domain interface; other site
400673007550	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
400673007551	16S/18S rRNA binding site [nucleotide binding]; other site
400673007552	S13e-L30e interaction site [polypeptide binding]; other site
400673007553	25S rRNA binding site [nucleotide binding]; other site
400673007554	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
400673007555	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
400673007556	RNA binding site [nucleotide binding]; other site
400673007557	active site
400673007558	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
400673007559	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
400673007560	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
400673007561	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
400673007562	translation initiation factor IF-2; Region: IF-2; TIGR00487
400673007563	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
400673007564	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
400673007565	G1 box; other site
400673007566	putative GEF interaction site [polypeptide binding]; other site
400673007567	GTP/Mg2+ binding site [chemical binding]; other site
400673007568	Switch I region; other site
400673007569	G2 box; other site
400673007570	G3 box; other site
400673007571	Switch II region; other site
400673007572	G4 box; other site
400673007573	G5 box; other site
400673007574	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
400673007575	Translation-initiation factor 2; Region: IF-2; pfam11987
400673007576	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
400673007577	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
400673007578	NusA N-terminal domain; Region: NusA_N; pfam08529
400673007579	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
400673007580	RNA binding site [nucleotide binding]; other site
400673007581	homodimer interface [polypeptide binding]; other site
400673007582	NusA-like KH domain; Region: KH_5; pfam13184
400673007583	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
400673007584	G-X-X-G motif; other site
400673007585	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
400673007586	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
400673007587	ribosome maturation protein RimP; Reviewed; Region: PRK00092
400673007588	Sm and related proteins; Region: Sm_like; cl00259
400673007589	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
400673007590	putative oligomer interface [polypeptide binding]; other site
400673007591	putative RNA binding site [nucleotide binding]; other site
400673007592	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
400673007593	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
400673007594	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
400673007595	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
400673007596	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
400673007597	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
400673007598	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
400673007599	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
400673007600	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
400673007601	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
400673007602	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
400673007603	4Fe-4S binding domain; Region: Fer4; cl02805
400673007604	4Fe-4S binding domain; Region: Fer4; pfam00037
400673007605	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
400673007606	NADH dehydrogenase subunit G; Validated; Region: PRK09129
400673007607	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
400673007608	catalytic loop [active]
400673007609	iron binding site [ion binding]; other site
400673007610	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
400673007611	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
400673007612	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
400673007613	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
400673007614	SLBB domain; Region: SLBB; pfam10531
400673007615	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
400673007616	NADH dehydrogenase subunit E; Validated; Region: PRK07539
400673007617	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
400673007618	putative dimer interface [polypeptide binding]; other site
400673007619	[2Fe-2S] cluster binding site [ion binding]; other site
400673007620	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
400673007621	NADH dehydrogenase subunit D; Validated; Region: PRK06075
400673007622	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
400673007623	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
400673007624	NADH dehydrogenase subunit B; Validated; Region: PRK06411
400673007625	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
400673007626	Preprotein translocase SecG subunit; Region: SecG; pfam03840
400673007627	triosephosphate isomerase; Provisional; Region: PRK14567
400673007628	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
400673007629	substrate binding site [chemical binding]; other site
400673007630	dimer interface [polypeptide binding]; other site
400673007631	catalytic triad [active]
400673007632	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
400673007633	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
400673007634	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
400673007635	active site
400673007636	substrate binding site [chemical binding]; other site
400673007637	metal binding site [ion binding]; metal-binding site
400673007638	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
400673007639	dihydropteroate synthase; Region: DHPS; TIGR01496
400673007640	substrate binding pocket [chemical binding]; other site
400673007641	dimer interface [polypeptide binding]; other site
400673007642	inhibitor binding site; inhibition site
400673007643	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
400673007644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673007645	Walker A motif; other site
400673007646	ATP binding site [chemical binding]; other site
400673007647	Walker B motif; other site
400673007648	arginine finger; other site
400673007649	Peptidase family M41; Region: Peptidase_M41; pfam01434
400673007650	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
400673007651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007652	S-adenosylmethionine binding site [chemical binding]; other site
400673007653	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
400673007654	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
400673007655	IucA / IucC family; Region: IucA_IucC; pfam04183
400673007656	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
400673007657	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
400673007658	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
400673007659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
400673007660	Walker A motif; other site
400673007661	ATP binding site [chemical binding]; other site
400673007662	Walker B motif; other site
400673007663	arginine finger; other site
400673007664	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
400673007665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673007666	putative substrate translocation pore; other site
400673007667	POT family; Region: PTR2; cl17359
400673007668	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
400673007669	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
400673007670	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
400673007671	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
400673007672	shikimate binding site; other site
400673007673	NAD(P) binding site [chemical binding]; other site
400673007674	aminopeptidase N; Provisional; Region: pepN; PRK14015
400673007675	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
400673007676	active site
400673007677	Zn binding site [ion binding]; other site
400673007678	PrkA family serine protein kinase; Provisional; Region: PRK15455
400673007679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
400673007680	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
400673007681	hypothetical protein; Provisional; Region: PRK05325
400673007682	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
400673007683	SpoVR family protein; Provisional; Region: PRK11767
400673007684	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
400673007685	Peptidase family M28; Region: Peptidase_M28; pfam04389
400673007686	active site
400673007687	metal binding site [ion binding]; metal-binding site
400673007688	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
400673007689	Part of AAA domain; Region: AAA_19; pfam13245
400673007690	Family description; Region: UvrD_C_2; pfam13538
400673007691	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
400673007692	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
400673007693	dimerization interface [polypeptide binding]; other site
400673007694	domain crossover interface; other site
400673007695	redox-dependent activation switch; other site
400673007696	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
400673007697	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
400673007698	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
400673007699	active site
400673007700	catalytic tetrad [active]
400673007701	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
400673007702	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
400673007703	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
400673007704	G1 box; other site
400673007705	putative GEF interaction site [polypeptide binding]; other site
400673007706	GTP/Mg2+ binding site [chemical binding]; other site
400673007707	Switch I region; other site
400673007708	G2 box; other site
400673007709	G3 box; other site
400673007710	Switch II region; other site
400673007711	G4 box; other site
400673007712	G5 box; other site
400673007713	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
400673007714	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
400673007715	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
400673007716	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
400673007717	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
400673007718	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
400673007719	Walker A/P-loop; other site
400673007720	ATP binding site [chemical binding]; other site
400673007721	Q-loop/lid; other site
400673007722	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
400673007723	ABC transporter signature motif; other site
400673007724	Walker B; other site
400673007725	D-loop; other site
400673007726	H-loop/switch region; other site
400673007727	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
400673007728	DNA-binding site [nucleotide binding]; DNA binding site
400673007729	RNA-binding motif; other site
400673007730	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
400673007731	conserved cys residue [active]
400673007732	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
400673007733	Amidinotransferase; Region: Amidinotransf; pfam02274
400673007734	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
400673007735	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
400673007736	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
400673007737	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
400673007738	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
400673007739	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
400673007740	RNA binding site [nucleotide binding]; other site
400673007741	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
400673007742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007743	S-adenosylmethionine binding site [chemical binding]; other site
400673007744	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
400673007745	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
400673007746	glutaminase active site [active]
400673007747	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
400673007748	dimer interface [polypeptide binding]; other site
400673007749	active site
400673007750	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
400673007751	dimer interface [polypeptide binding]; other site
400673007752	active site
400673007753	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
400673007754	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
400673007755	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
400673007756	active site
400673007757	oxyanion hole [active]
400673007758	catalytic triad [active]
400673007759	rhodanese superfamily protein; Provisional; Region: PRK05320
400673007760	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
400673007761	active site residue [active]
400673007762	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
400673007763	SmpB-tmRNA interface; other site
400673007764	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
400673007765	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
400673007766	catalytic triad [active]
400673007767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
400673007768	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
400673007769	putative substrate translocation pore; other site
400673007770	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
400673007771	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
400673007772	putative active site [active]
400673007773	PhoH-like protein; Region: PhoH; pfam02562
400673007774	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
400673007775	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
400673007776	active site
400673007777	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
400673007778	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
400673007779	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
400673007780	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
400673007781	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
400673007782	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
400673007783	B1 nucleotide binding pocket [chemical binding]; other site
400673007784	B2 nucleotide binding pocket [chemical binding]; other site
400673007785	CAS motifs; other site
400673007786	active site
400673007787	TPR repeat; Region: TPR_11; pfam13414
400673007788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673007789	TPR motif; other site
400673007790	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
400673007791	Methyltransferase domain; Region: Methyltransf_24; pfam13578
400673007792	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
400673007793	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
400673007794	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
400673007795	Amidase; Region: Amidase; cl11426
400673007796	Oxygen tolerance; Region: BatD; pfam13584
400673007797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
400673007798	binding surface
400673007799	TPR motif; other site
400673007800	Tetratricopeptide repeat; Region: TPR_16; pfam13432
400673007801	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
400673007802	metal ion-dependent adhesion site (MIDAS); other site
400673007803	Aerotolerance regulator N-terminal; Region: BatA; cl06567
400673007804	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
400673007805	metal ion-dependent adhesion site (MIDAS); other site
400673007806	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
400673007807	Protein of unknown function DUF58; Region: DUF58; pfam01882
400673007808	MoxR-like ATPases [General function prediction only]; Region: COG0714
400673007809	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
400673007810	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
400673007811	FMN binding site [chemical binding]; other site
400673007812	active site
400673007813	catalytic residues [active]
400673007814	substrate binding site [chemical binding]; other site
400673007815	pteridine reductase; Provisional; Region: PRK09135
400673007816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673007817	NAD(P) binding site [chemical binding]; other site
400673007818	active site
400673007819	Uncharacterized conserved protein [Function unknown]; Region: COG1565
400673007820	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
400673007821	primosome assembly protein PriA; Validated; Region: PRK05580
400673007822	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
400673007823	ATP binding site [chemical binding]; other site
400673007824	putative Mg++ binding site [ion binding]; other site
400673007825	helicase superfamily c-terminal domain; Region: HELICc; smart00490
400673007826	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
400673007827	active site
400673007828	thymidylate synthase; Reviewed; Region: thyA; PRK01827
400673007829	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
400673007830	dimerization interface [polypeptide binding]; other site
400673007831	active site
400673007832	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
400673007833	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
400673007834	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
400673007835	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
400673007836	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
400673007837	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
400673007838	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
400673007839	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
400673007840	putative active site [active]
400673007841	Ap4A binding site [chemical binding]; other site
400673007842	nudix motif; other site
400673007843	putative metal binding site [ion binding]; other site
400673007844	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
400673007845	active site
400673007846	homodimer interface [polypeptide binding]; other site
400673007847	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
400673007848	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
400673007849	Substrate binding site; other site
400673007850	Mg++ binding site; other site
400673007851	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
400673007852	active site
400673007853	substrate binding site [chemical binding]; other site
400673007854	CoA binding site [chemical binding]; other site
400673007855	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
400673007856	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
400673007857	transmembrane helices; other site
400673007858	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
400673007859	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
400673007860	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
400673007861	oligomer interface [polypeptide binding]; other site
400673007862	metal binding site [ion binding]; metal-binding site
400673007863	metal binding site [ion binding]; metal-binding site
400673007864	Cl binding site [ion binding]; other site
400673007865	aspartate ring; other site
400673007866	basic sphincter; other site
400673007867	putative hydrophobic gate; other site
400673007868	periplasmic entrance; other site
400673007869	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
400673007870	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
400673007871	minor groove reading motif; other site
400673007872	helix-hairpin-helix signature motif; other site
400673007873	substrate binding pocket [chemical binding]; other site
400673007874	active site
400673007875	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
400673007876	ferredoxin; Provisional; Region: PRK08764
400673007877	Putative Fe-S cluster; Region: FeS; pfam04060
400673007878	4Fe-4S binding domain; Region: Fer4; pfam00037
400673007879	4Fe-4S binding domain; Region: Fer4; cl02805
400673007880	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
400673007881	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
400673007882	active site
400673007883	HIGH motif; other site
400673007884	KMSKS motif; other site
400673007885	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
400673007886	anticodon binding site; other site
400673007887	tRNA binding surface [nucleotide binding]; other site
400673007888	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
400673007889	dimer interface [polypeptide binding]; other site
400673007890	putative tRNA-binding site [nucleotide binding]; other site
400673007891	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
400673007892	Flavoprotein; Region: Flavoprotein; pfam02441
400673007893	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
400673007894	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
400673007895	Ligand Binding Site [chemical binding]; other site
400673007896	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
400673007897	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
400673007898	Substrate binding site; other site
400673007899	Cupin domain; Region: Cupin_2; cl17218
400673007900	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
400673007901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
400673007902	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
400673007903	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
400673007904	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
400673007905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007906	S-adenosylmethionine binding site [chemical binding]; other site
400673007907	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
400673007908	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
400673007909	P-loop; other site
400673007910	Magnesium ion binding site [ion binding]; other site
400673007911	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
400673007912	Magnesium ion binding site [ion binding]; other site
400673007913	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
400673007914	ParB-like nuclease domain; Region: ParBc; pfam02195
400673007915	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
400673007916	putative active site [active]
400673007917	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
400673007918	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
400673007919	Predicted transcriptional regulator [Transcription]; Region: COG3655
400673007920	salt bridge; other site
400673007921	non-specific DNA binding site [nucleotide binding]; other site
400673007922	sequence-specific DNA binding site [nucleotide binding]; other site
400673007923	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
400673007924	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
400673007925	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
400673007926	Coenzyme A binding pocket [chemical binding]; other site
400673007927	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
400673007928	Subunit III/VIIa interface [polypeptide binding]; other site
400673007929	Phospholipid binding site [chemical binding]; other site
400673007930	Subunit I/III interface [polypeptide binding]; other site
400673007931	Subunit III/VIb interface [polypeptide binding]; other site
400673007932	Subunit III/VIa interface; other site
400673007933	Subunit III/Vb interface [polypeptide binding]; other site
400673007934	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
400673007935	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
400673007936	Subunit I/III interface [polypeptide binding]; other site
400673007937	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
400673007938	D-pathway; other site
400673007939	Subunit I/VIIc interface [polypeptide binding]; other site
400673007940	Subunit I/IV interface [polypeptide binding]; other site
400673007941	Subunit I/II interface [polypeptide binding]; other site
400673007942	Low-spin heme (heme a) binding site [chemical binding]; other site
400673007943	Subunit I/VIIa interface [polypeptide binding]; other site
400673007944	Subunit I/VIa interface [polypeptide binding]; other site
400673007945	Dimer interface; other site
400673007946	Putative water exit pathway; other site
400673007947	Binuclear center (heme a3/CuB) [ion binding]; other site
400673007948	K-pathway; other site
400673007949	Subunit I/Vb interface [polypeptide binding]; other site
400673007950	Putative proton exit pathway; other site
400673007951	Subunit I/VIb interface; other site
400673007952	Subunit I/VIc interface [polypeptide binding]; other site
400673007953	Electron transfer pathway; other site
400673007954	Subunit I/VIIIb interface [polypeptide binding]; other site
400673007955	Subunit I/VIIb interface [polypeptide binding]; other site
400673007956	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
400673007957	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
400673007958	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
400673007959	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
400673007960	Cytochrome c; Region: Cytochrom_C; pfam00034
400673007961	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
400673007962	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
400673007963	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
400673007964	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
400673007965	iron-sulfur cluster [ion binding]; other site
400673007966	[2Fe-2S] cluster binding site [ion binding]; other site
400673007967	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
400673007968	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
400673007969	Lysine efflux permease [General function prediction only]; Region: COG1279
400673007970	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
400673007971	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
400673007972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
400673007973	S-adenosylmethionine binding site [chemical binding]; other site
400673007974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
400673007975	SCP-2 sterol transfer family; Region: SCP2; pfam02036
400673007976	SCP-2 sterol transfer family; Region: SCP2; cl01225
400673007977	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
400673007978	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
400673007979	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
400673007980	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
400673007981	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
400673007982	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
400673007983	methionine sulfoxide reductase A; Provisional; Region: PRK14054
400673007984	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
400673007985	tyramine oxidase; Provisional; Region: tynA; PRK11504
400673007986	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
400673007987	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
400673007988	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
400673007989	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
400673007990	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
400673007991	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
400673007992	DNA-binding interface [nucleotide binding]; DNA binding site
400673007993	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
400673007994	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
400673007995	catalytic nucleophile [active]
400673007996	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
400673007997	Transglycosylase SLT domain; Region: SLT_2; pfam13406
400673007998	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
400673007999	N-acetyl-D-glucosamine binding site [chemical binding]; other site
400673008000	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
400673008001	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
400673008002	FtsX-like permease family; Region: FtsX; pfam02687
400673008003	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
400673008004	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
400673008005	Walker A/P-loop; other site
400673008006	ATP binding site [chemical binding]; other site
400673008007	Q-loop/lid; other site
400673008008	ABC transporter signature motif; other site
400673008009	Walker B; other site
400673008010	D-loop; other site
400673008011	H-loop/switch region; other site
400673008012	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
400673008013	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
400673008014	HlyD family secretion protein; Region: HlyD_3; pfam13437
400673008015	Outer membrane efflux protein; Region: OEP; pfam02321
400673008016	Outer membrane efflux protein; Region: OEP; pfam02321
400673008017	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
400673008018	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
400673008019	active site
400673008020	metal binding site [ion binding]; metal-binding site
400673008021	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
400673008022	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
400673008023	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
400673008024	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
400673008025	S-adenosylmethionine binding site [chemical binding]; other site
400673008026	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
400673008027	tetramerization interface [polypeptide binding]; other site
400673008028	active site
400673008029	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
400673008030	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
400673008031	FMN reductase; Validated; Region: fre; PRK08051
400673008032	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
400673008033	FAD binding pocket [chemical binding]; other site
400673008034	FAD binding motif [chemical binding]; other site
400673008035	phosphate binding motif [ion binding]; other site
400673008036	beta-alpha-beta structure motif; other site
400673008037	NAD binding pocket [chemical binding]; other site
400673008038	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
400673008039	transcription termination factor Rho; Provisional; Region: rho; PRK09376
400673008040	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
400673008041	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
400673008042	RNA binding site [nucleotide binding]; other site
400673008043	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
400673008044	multimer interface [polypeptide binding]; other site
400673008045	Walker A motif; other site
400673008046	ATP binding site [chemical binding]; other site
400673008047	Walker B motif; other site
400673008048	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
400673008049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
400673008050	catalytic residues [active]
400673008051	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
400673008052	RNA methyltransferase, RsmE family; Region: TIGR00046
400673008053	fumarate hydratase; Reviewed; Region: fumC; PRK00485
400673008054	Class II fumarases; Region: Fumarase_classII; cd01362
400673008055	active site
400673008056	tetramer interface [polypeptide binding]; other site
400673008057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
400673008058	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
400673008059	putative acyl-acceptor binding pocket; other site
400673008060	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
400673008061	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
400673008062	putative acyl-acceptor binding pocket; other site
400673008063	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
400673008064	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
400673008065	active site
400673008066	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
400673008067	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
400673008068	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
400673008069	trimer interface [polypeptide binding]; other site
400673008070	active site
400673008071	UDP-GlcNAc binding site [chemical binding]; other site
400673008072	lipid binding site [chemical binding]; lipid-binding site
400673008073	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
400673008074	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
400673008075	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
400673008076	active site
400673008077	nucleotide-binding site [chemical binding]; other site
400673008078	metal-binding site [ion binding]
400673008079	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
400673008080	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
400673008081	Walker A/P-loop; other site
400673008082	ATP binding site [chemical binding]; other site
400673008083	Q-loop/lid; other site
400673008084	ABC transporter signature motif; other site
400673008085	Walker B; other site
400673008086	D-loop; other site
400673008087	H-loop/switch region; other site
400673008088	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
400673008089	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
400673008090	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
400673008091	active site
400673008092	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
400673008093	Ligand Binding Site [chemical binding]; other site
400673008094	Molecular Tunnel; other site
400673008095	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
400673008096	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
400673008097	dimer interface [polypeptide binding]; other site
400673008098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673008099	catalytic residue [active]
400673008100	Histone methylation protein DOT1; Region: DOT1; pfam08123
400673008101	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
400673008102	IHF dimer interface [polypeptide binding]; other site
400673008103	IHF - DNA interface [nucleotide binding]; other site
400673008104	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
400673008105	trimer interface [polypeptide binding]; other site
400673008106	active site
400673008107	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
400673008108	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
400673008109	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
400673008110	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
400673008111	dimer interface [polypeptide binding]; other site
400673008112	active site residues [active]
400673008113	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
400673008114	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673008115	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
400673008116	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
400673008117	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
400673008118	ligand binding site [chemical binding]; other site
400673008119	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
400673008120	active site
400673008121	substrate binding pocket [chemical binding]; other site
400673008122	dimer interface [polypeptide binding]; other site
400673008123	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
400673008124	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
400673008125	dimer interface [polypeptide binding]; other site
400673008126	catalytic site [active]
400673008127	putative active site [active]
400673008128	putative substrate binding site [chemical binding]; other site
400673008129	peroxidase; Provisional; Region: PRK15000
400673008130	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
400673008131	dimer interface [polypeptide binding]; other site
400673008132	decamer (pentamer of dimers) interface [polypeptide binding]; other site
400673008133	catalytic triad [active]
400673008134	peroxidatic and resolving cysteines [active]
400673008135	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
400673008136	putative GSH binding site [chemical binding]; other site
400673008137	catalytic residues [active]
400673008138	superoxide dismutase; Provisional; Region: PRK10543
400673008139	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
400673008140	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
400673008141	acetylornithine aminotransferase; Provisional; Region: PRK02627
400673008142	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
400673008143	inhibitor-cofactor binding pocket; inhibition site
400673008144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
400673008145	catalytic residue [active]
400673008146	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
400673008147	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
400673008148	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
400673008149	active site
400673008150	catalytic site [active]
400673008151	malate dehydrogenase; Provisional; Region: PRK13529
400673008152	Malic enzyme, N-terminal domain; Region: malic; pfam00390
400673008153	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
400673008154	NAD(P) binding site [chemical binding]; other site
400673008155	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
400673008156	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
400673008157	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
400673008158	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
400673008159	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
400673008160	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
400673008161	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
400673008162	active site
400673008163	Zn binding site [ion binding]; other site
400673008164	Rossmann-like domain; Region: Rossmann-like; pfam10727
400673008165	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
400673008166	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
400673008167	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
400673008168	CAP-like domain; other site
400673008169	active site
400673008170	primary dimer interface [polypeptide binding]; other site
400673008171	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
400673008172	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
400673008173	gamma subunit interface [polypeptide binding]; other site
400673008174	LBP interface [polypeptide binding]; other site
400673008175	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
400673008176	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
400673008177	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
400673008178	alpha subunit interaction interface [polypeptide binding]; other site
400673008179	Walker A motif; other site
400673008180	ATP binding site [chemical binding]; other site
400673008181	Walker B motif; other site
400673008182	inhibitor binding site; inhibition site
400673008183	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
400673008184	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
400673008185	core domain interface [polypeptide binding]; other site
400673008186	delta subunit interface [polypeptide binding]; other site
400673008187	epsilon subunit interface [polypeptide binding]; other site
400673008188	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
400673008189	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
400673008190	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
400673008191	beta subunit interaction interface [polypeptide binding]; other site
400673008192	Walker A motif; other site
400673008193	ATP binding site [chemical binding]; other site
400673008194	Walker B motif; other site
400673008195	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
400673008196	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
400673008197	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
400673008198	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
400673008199	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
400673008200	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
400673008201	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
400673008202	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
400673008203	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
400673008204	outer membrane lipoprotein; Provisional; Region: PRK11023
400673008205	BON domain; Region: BON; pfam04972
400673008206	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
400673008207	BON domain; Region: BON; pfam04972
400673008208	BON domain; Region: BON; cl02771
400673008209	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
400673008210	dimer interface [polypeptide binding]; other site
400673008211	active site
400673008212	hypothetical protein; Reviewed; Region: PRK12497
400673008213	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
400673008214	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
400673008215	putative ligand binding site [chemical binding]; other site
400673008216	Predicted methyltransferases [General function prediction only]; Region: COG0313
400673008217	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
400673008218	putative SAM binding site [chemical binding]; other site
400673008219	putative homodimer interface [polypeptide binding]; other site
400673008220	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
400673008221	Fatty acid desaturase; Region: FA_desaturase; pfam00487
400673008222	Di-iron ligands [ion binding]; other site
400673008223	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
400673008224	Sulfate transporter family; Region: Sulfate_transp; pfam00916
400673008225	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
400673008226	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
400673008227	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
400673008228	ligand binding site [chemical binding]; other site
400673008229	flexible hinge region; other site
400673008230	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
400673008231	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
400673008232	active site
400673008233	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
400673008234	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
400673008235	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
400673008236	GTP/Mg2+ binding site [chemical binding]; other site
400673008237	G4 box; other site
400673008238	G5 box; other site
400673008239	trmE is a tRNA modification GTPase; Region: trmE; cd04164
400673008240	G1 box; other site
400673008241	G1 box; other site
400673008242	GTP/Mg2+ binding site [chemical binding]; other site
400673008243	Switch I region; other site
400673008244	Switch I region; other site
400673008245	G2 box; other site
400673008246	G2 box; other site
400673008247	Switch II region; other site
400673008248	G3 box; other site
400673008249	G4 box; other site
400673008250	G5 box; other site
400673008251	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
400673008252	membrane protein insertase; Provisional; Region: PRK01318
400673008253	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
400673008254	Ribonuclease P; Region: Ribonuclease_P; cl00457
400673008255	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399